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Systemic Lupus Erythematosus Autoimmune Diseases Systemic Lupus Erythematosus Guest Editors: Hiroshi Okamoto, Ricard Cervera, Tatiana S. Rodriguez-Reyna, Hiroyuki Nishimura, and Taku Yoshio Systemic Lupus Erythematosus Autoimmune Diseases Systemic Lupus Erythematosus Guest Editors: Hiroshi Okamoto, Ricard Cervera, Tatiana S. Rodriguez-Reyna, Hiroyuki Nishimura, and Taku Yoshio Copyright © 2012 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Autoimmune Diseases.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is prop- erly cited. Editorial Board Corrado Betterle, Italy Evelyn Hess, USA Markus Reindl, Austria Maria Bokarewa, Sweden Stephen Holdsworth, Australia Pere Santamaria, Canada Nalini S. Bora, USA Hiroshi Ikegami, Japan Giovanni Savettieri, Italy D. N. Bourdette, USA Francesco Indiveri, Italy Jin-Xiong She, USA Ricard Cervera, Spain Pietro Invernizzi, Italy Animesh A. Sinha, USA Edward K. L. Chan, USA Annegret Kuhn, Germany Jan Storek, Canada M. Cutolo, Italy I. R. Mackay, Australia Alexander J Szalai, USA George N. Dalekos, Greece Rizgar Mageed, UK Ronald F. Tuma, USA Thomas Dorner,¨ Germany Grant Morahan, Australia Edmond J. Yunis, USA Sudhir Gupta, USA Kamal D. Moudgil, USA Martin Herrmann, Germany Andras Perl, USA Contents Systemic Lupus Erythematosus, Hiroshi Okamoto, Ricard Cervera, Tatiana S. Rodriguez-Reyna, Hiroyuki Nishimura, and Taku Yoshio Volume 2012, Article ID 815753, 2 pages A Novel Method for Real-Time, Continuous, Fluorescence-Based Analysis of Anti-DNA Abzyme Activity in Systemic Lupus, Michelle F. Cavallo, Anna M. Kats, Ran Chen, James X. Hartmann, and Mirjana Pavlovic Volume 2012, Article ID 814048, 10 pages Role of Structure-Based Changes due to Somatic Mutation in Highly Homologous DNA-Binding and DNA-Hydrolyzing Autoantibodies Exemplified by A23P Substitution in the VH Domain,A.V.Kozyr, A. V. Kolesnikov, A. E. Khlyntseva, A. G. Bogun, G. A. Savchenko, I. G. Shemyakin, and A. G. Gabibov Volume 2012, Article ID 683829, 7 pages Screening Tests of Reproductive Immunology in Systemic Lupus Erythematosus, Zdenka Ulcova-Gallova, Alice Mockova, and Miroslava Cedikova Volume 2012, Article ID 812138, 6 pages Evaluation of ENA-6 Profile by ELISA Immunoassay in Patients with Systemic Lupus Erythematodes, Izeta Aganovic-Musinovic, Jasenko Karamehic, Lamija Zecevic, Faris Gavrankapetanovic, Nesina Avdagic, Asija Zaciragic, Tomislav Jukic, Nerima Grcic, and Suvada Svrakic Volume 2012, Article ID 321614, 8 pages Intravenous Immunoglobulin in the Management of Lupus Nephritis, Scott E. Wenderfer and Trisha Thacker Volume 2012, Article ID 589359, 10 pages Multiple Autoantibodies Display Association with Lymphopenia, Proteinuria, and Cellular Casts in a Large, Ethnically Diverse SLE Patient Cohort, Rufei Lu, Julie M. Robertson, Benjamin F. Bruner, Joel M. Guthridge, Barbara R. Neas, Swapan K. Nath, Jennifer A. Kelly, Kathy L. Moser Sivils, Eliza F. Chakravarty, Diane L. Kamen, Gary S. Gilkeson, Daniel J. Wallace, Michael H. Weisman, R. Hal Scofield, John B. Harley, and Judith A. James Volume 2012, Article ID 819634, 11 pages Neonatal Lupus Erythematosus, Kam Lun Hon and Alexander K. C. Leung Volume 2012, Article ID 301274, 6 pages Vascular Disease in Systemic Lupus Erythematosus, Athina Pyrpasopoulou, Sofia Chatzimichailidou, and Spyros Aslanidis Volume 2012, Article ID 876456, 4 pages Osteonecrosis in Systemic Lupus Erythematosus: An Early, Frequent, and Not Always Symptomatic Complication, Paola Caramaschi, Domenico Biasi, Ilaria Dal Forno, and Silvano Adami Volume 2012, Article ID 725249, 7 pages The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis, Susan Yung and Tak Mao Chan Volume 2012, Article ID 207190, 9 pages Cutaneous Manifestations of Systemic Lupus Erythematosus,Lu´ıs Uva, Diana Miguel, Catarina Pinheiro, Joao˜ Pedro Freitas, Manuel Marques Gomes, and Paulo Filipe Volume 2012, Article ID 834291, 15 pages Identification of TNIP1 Polymorphisms by High Resolution Melting Analysis with Unlabelled Probe: Association with Systemic Lupus Erythematosus, Jie Zhang, Yuewen Chen, Yong Shao, Qi Wu, Ming Guan, Wei Zhang, Jun Wan, and Bo Yu Volume 2012, Article ID 265823, 5 pages Ocular Manifestations of Systemic Lupus Erythematosus: A Review of the Literature, Neal V. Palejwala, Harpreet S. Walia, and Steven Yeh Volume 2012, Article ID 290898, 9 pages Hindawi Publishing Corporation Autoimmune Diseases Volume 2012, Article ID 815753, 2 pages doi:10.1155/2012/815753 Editorial Systemic Lupus Erythematosus Hiroshi Okamoto,1 Ricard Cervera,2 Tatiana S. Rodriguez-Reyna,3 Hiroyuki Nishimura,4 and Taku Yoshio5 1 Minami-Otsuka Clinic, Minami-Otsuka Institute of Technology, 2-41-9 Minami-Otsuka, Toshima-ku, Tokyo 170-0005, Japan 2 Department of Autoimmune Diseases, Hospital Clinic, Calle Villarroel, 170, Barcelona, Catalonia 08036, Spain 3 Department of Immunology and Rheumatology, National Institute of Medical Sciences and Nutrition Salvador Zubiran,´ Vasco de Quiroga 15, Colonia Seccion´ XVI, 14000 Mexico City, DF, Mexico 4 Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-machi, Aoba-ku, Yokohama 225-8802, Japan 5 Division of Rheumatology and Clinical Immunology, School of Medicine, Jichi Medical University, 3311 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Correspondence should be addressed to Hiroshi Okamoto, [email protected] Received 1 November 2012; Accepted 1 November 2012 Copyright © 2012 Hiroshi Okamoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Systemic lupus erythematosus (SLE) is an autoimmune dis- To understand the pathogenesis of SLE, genetic back- ease characterized by widespread immunologic abnormali- ground, several small molecules, and autoantigens/autoan- ties and multiorgan involvement including the skin, joints, tibodies are extensively studied. In this special issue, we have and kidney as well as the peripheral and central nervous several articles to introduce the recent topics in this field. systems. The clinical course of SLE is usually dependent The extracellular matrix (ECM) is not only a structural on the organ involved such as neuropsychiatric syndromes support that maintains the architecture of tissues and organs, of systemic lupus erythematosus (NPSLE), lupus nephritis but also plays critical roles during inflammatory processes. (LN), lupus pancreatitis (LP), and pulmonary hypertension Hyaluronan (HA) is a major component of the ECM that (PH). Early diagnosis and epoch-making therapeutic strate- can directly regulate inflammatory processes through its gies are prerequisites for improved prognosis of patients with interaction with its cell surface receptor CD44. In this special SLE. To fulfill this medical need, a better understanding of issue there is an outstanding review on the pathogenesis of the pathogenesis of SLE is required. Research over the course SLE. S. Yung and T. M. Chan overviewed and discussed the of several years has yielded a basic scientific understanding putative mechanisms through which hyaluronan and its cell of SLE pathogenesis. This includes understanding the role of surface receptor, CD44, contribute to the pathogenesis of various cytokines and chemokines in disease progression, the SLE, with particular emphasis on lupus nephritis. chronic activation of plasmacytoid dendritic cells by circu- Recently, the genetic background of SLE was revealed lating immune complexes, and the expression of neutrophil- by a series of genome-wide association studies (GWAS) specific genes. and several SLE susceptive genes including MHC, BLK, The main focus of this special issue is on the diagnostic ITGAM, STAT4, IRF5, BANK1,andETS1 were identified. tools for organ involvement in SLE and in the development of The polymorphisms on TNFα-induced protein 3 (TNFAIP3 new therapeutic strategies as well as the basic understanding or A20) interacting protein1 (TNIP1) have been reported to of SLE pathogenesis. Thankfully, we have several research associate with the disease risk of several autoimmune diseases articles as well as outstanding review articles on this subject. including SLE in Caucasians. J. Zhang et al. investigated the We hope this special issue is an international forum for association of TNIP1 with SLE in the Chinese population researchers and clinicians to summarize the most recent using high-resolution melting (HRM) analysis. Although developments and ideas in the field. they found no association between TNIP1 SNPs with the 2 Autoimmune Diseases disease risk of SLE in the Chinese population, they found a lesions as well as SLE nonspecific skin manifestations, their new SNP rs79937737 located on 5 bp upstream of rs7708392. pathophysiology, and management. This review includes SLE is characterized by diverse clinical symptoms and typical pictures of various types of cutaneous lesions and also autoantibody production against a variety of nuclear and provides us a great lesson to learn. cytoplasmic antigens. The occurrence and prevalence of Vascular disease is frequent in patients with SLE and these autoantibody specificities have been used to char- represents the most frequent cause of death in established acterize the diverse clinical presentations of SLE. The disease. A. Pyrpasopoulou et al. overviewed
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