Diseases Tiunsmitted by Foods
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Food Allergy • Higher Prevalence in Children: Many Food Allergic Children Develop Immune Tolerance Background Ctd
Overview of Food-Related Adverse Reactions ALLSA 2017 Dr Claudia Gray Dr Claudia Gray • MBChB, FRCPCH (London), MSc (Surrey), Dip Allergy (Southampton), DipPaedNutrition(UK), PhD (UCT) • Paediatrician and Allergologist, UCT Lung Institute • Red Cross Children’s Hospital Allergy and Asthma Department • [email protected] Background 1. Food allergies are common: • Infants: 6-10%; children 2-8%, adults 1-2% true food allergy • Higher prevalence in children: many food allergic children develop immune tolerance Background ctd 2. Food allergies are increasing: • Peanut allergy in UK doubled in 1-2 decades: 1.8%. ? Stabilising in some regions Background 3. Spectrum changing: • Multiple food allergies increasing • “Rare” food allergies are increasing e.g. Eosinophilic oesophagitis; FPIES Allergenic Foods • Prevalence of food allergies influenced by geography and diet; egg and milk allergy universally common • Relatively small number of food types cause the majority of reactions: Allergenic Foods Young Children Adults • Cow’s milk • Fin-fish • Hen’s Egg • Shellfish • Wheat • Treenut • Soya • Peanut • Peanut • Fruit and vegetables • Treenut • Sesame • Kiwi • (* persistence likely) Allergenic Foods • A single food allergen can induce a range of allergic reactions e.g. wheat Classification of Adverse reactions to Food Classification of adverse reactions to food Adverse Reaction to food May occur in all Occurs only in some individuals if they eat susceptible sufficient quantity individuals Pharma- Micro- Toxic Food Food (e.g. cological biological scromboid) e.g. e.g food aversion hypersensitivity tyramine poisoning Classification of adverse reactions to food Food Hypersensitivity Non-allergic food Food Allergy hypersensitivity Mixed IgE- Unknown Metabolic IgE- and non Non IgE- e.g. -
Food Safety Risk Assessment Related to Methylmercury in Seafood August 4
※ This report is translated by Food Safety Commission Secretariat, The Cabinet Office, Japan. Food Safety Risk Assessment Related to Methylmercury in Seafood August 4,2005 The Food Safety Commission, Japan The Contaminant Expert Committee Methylmercury in Seafood 1. Introduction To assure safety against methylmercury in seafood, the Ministry of Health, Labour and Welfare collected opinions of Joint Sub-Committees on Animal Origin Foods and Toxicology under the Food Sanitation Committee (Pharmaceutical Affairs and Food Sanitation Council(1))and published “Advice for Pregnant Women on Fish Consumption concerning Mercury Contamination” for pregnant and potentially pregnant women. Subsequently, after the application of the conventional assessment to a general population was reconfirmed, methylmercury was reassessed in the 61st Joint FAO/WHO Expert Committee on Food Additives (JECFA) in mid-June 2003 with a concern that fetuses and infants might have greater risks, based upon the results of epidemiological studies conducted in the Seychelles and Faroe Islands on effects of prenatal exposure to methylmercury via seafood on child neurodevelopment(the 61st JECFA (2), WHO (3)). To reassess the above Advice, the Ministry of Health, Labour and Welfare recently requested a food safety risk assessment of “methylmercury in seafood” to the Food Safety Committee in the document No. 07230001 from the Department of Food Safety, Pharmaceutical and Food Safety Bureau, Ministry of Health, Labour and Welfare under the date of July 23, 2004, in accordance with Article 24, Paragraph 3, Food Safety Basic Law (Law No. 48 2003). The concrete contents of the document requested for not only setting a tolerable intake of methylmercury to reassess the Advice for pregnant women and others concerning intake of methylmercury in seafood, but also discussing a high-risk group that might be subject to the Advice, since the high-risk group is not necessarily the same as those in foreign countries. -
Neurotoxicity: Identifying and Controlling Poisons of the Nervous System
Index -i abused drugs activities of, 33, 81, 88, 322 addiction, 6, 52,74, 75 aldicarb, 47, 173,251 designer drugs, 51 aldrin, 250,252,292 effects on nervous system, 6,9, 51–53, 71 allyl chloride, 303 health costs of, 20,53,232 aluminum, 48 psychoactive drugs, 6, 10,27,44,50 and Alzheimer’s disease, 54-55 withdrawal from, 74 oxide, 14, 136 see also specific drugs Alzheimer’s disease academic research effects on hippocampus, 71 cooperative agreements with government, 94 environmental cause, 3, 6, 54-55, 70, 72 factors influencing directions of, 92-94 research on, 259 acetaldehyde, 297 American Academy of Pediatrics, 189 acetone, 14, 136,296, 297,303 American Conference of Governmental Industrial Hygienists, acetylcholine, 26, 66, 109, 124,294, 336 28, 151, 185, 186,203,302-303 acetylcholinesterase, 11,50,74,84,187,203, 289,290-292,336 American National Standards Institute, 185 acetylethyl tetramethyl tetralin (AETT) ammonia, 14, 136 exposure route, 108 amphetamines, 74 incidents of poisoning, 47, 54 amyotrophic lateral sclerosis neurological effects of, 54 characteristics of, 54 acrylamide, 73, 120 environmental cause, 3, 6, 54-55, 70, 72 neurotoxicity testing, 166, 175 incidence of, 54, 55 regulation for neurotoxicity, 178 research on, 259 risk assessment approaches, 150, 151,216 anencephaly, 70 research on neurotoxicity, 258 anilines and substituted anilines, 179 acrylates, 175 animal tests, 13 acrylonitrile, 203 accuracy and reliability, 106, 115 neurotoxicity testing, 166, 173 advantages and limitations of, 105, 106, 111, 112, 114, -
Point Mutation Detection in the Cotton Rat. Christine H
Louisiana State University LSU Digital Commons LSU Historical Dissertations and Theses Graduate School 2000 Indices of Exposure to Polycyclic Aromatic Hydrocarbons in a Bioindicator Species: Point Mutation Detection in the Cotton Rat. Christine H. Lemarchand-carpentier Louisiana State University and Agricultural & Mechanical College Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_disstheses Recommended Citation Lemarchand-carpentier, Christine H., "Indices of Exposure to Polycyclic Aromatic Hydrocarbons in a Bioindicator Species: Point Mutation Detection in the Cotton Rat." (2000). LSU Historical Dissertations and Theses. 7277. https://digitalcommons.lsu.edu/gradschool_disstheses/7277 This Dissertation is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Historical Dissertations and Theses by an authorized administrator of LSU Digital Commons. For more information, please contact [email protected]. INFORMATION TO USERS This manuscript has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. -
Neuromuscular Disorders Neurology in Practice: Series Editors: Robert A
Neuromuscular Disorders neurology in practice: series editors: robert a. gross, department of neurology, university of rochester medical center, rochester, ny, usa jonathan w. mink, department of neurology, university of rochester medical center,rochester, ny, usa Neuromuscular Disorders edited by Rabi N. Tawil, MD Professor of Neurology University of Rochester Medical Center Rochester, NY, USA Shannon Venance, MD, PhD, FRCPCP Associate Professor of Neurology The University of Western Ontario London, Ontario, Canada A John Wiley & Sons, Ltd., Publication This edition fi rst published 2011, ® 2011 by Blackwell Publishing Ltd Blackwell Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing program has been merged with Wiley’s global Scientifi c, Technical and Medical business to form Wiley-Blackwell. Registered offi ce: John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK Editorial offi ces: 9600 Garsington Road, Oxford, OX4 2DQ, UK The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK 111 River Street, Hoboken, NJ 07030-5774, USA For details of our global editorial offi ces, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley-blackwell The right of the author to be identifi ed as the author of this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher. -
Histamine Poisoning Fact Sheet
Histamine Poisoning Fact Sheet What is Histamine? How much histamine is a harmful dose? Scombroid food poisoning is caused by A threshold dose is considered to be 90 mg/100 ingestion of histamine, a product of the g. Although, levels as low as 5-20 mg/ 100 g could degradation of the amino acid histidine. possibly be toxic; particularly in susceptible Histidine can be found freely in the muscles individuals. of some fish species and can be degraded to What are the symptoms? histamine by enzymatic action of some naturally occurring bacteria. Initial symptoms resemble some allergic reactions which include sweating, nausea, headache and tingling or peppery sensation in the mouth and Which types of fish can be implicated? throat. The scombrid fish such as tuna and mackerel are Other symptoms include urticarial rash (hives), traditionally considered to present the highest localised skin inflammation, vomiting, diarrhoea, risk. However, other species have also been abdominal cramps, flushing of the face and low associated with histamine poisoning; e.g. blood pressure. anchovies, sardines, Yellowtail kingfish, Amberjack and Australian salmon, Mahi Mahi and Severe symptoms include blurred vision, severe Escolar. respiratory distress and swelling of the tongue. Which bacteria are involved? What can be done to manage histamine in seafood? A variety of bacterial genera have implicated in the formation of histamine; e.g. Clostridium, • Histamine levels can increase over a wide Morganella, Pseudomonas, Photobacterium, range of storage temperatures. However, Brochothrix and Carnobacterium. histamine production is highest over 21.8 °C. Once the enzyme is present in the fish, it can What outbreaks have occurred? continue to produce histamine at refrigeration temperatures. -
Question of the Day Archives: Monday, December 5, 2016 Question: Calcium Oxalate Is a Widespread Toxin Found in Many Species of Plants
Question Of the Day Archives: Monday, December 5, 2016 Question: Calcium oxalate is a widespread toxin found in many species of plants. What is the needle shaped crystal containing calcium oxalate called and what is the compilation of these structures known as? Answer: The needle shaped plant-based crystals containing calcium oxalate are known as raphides. A compilation of raphides forms the structure known as an idioblast. (Lim CS et al. Atlas of select poisonous plants and mushrooms. 2016 Disease-a-Month 62(3):37-66) Friday, December 2, 2016 Question: Which oral chelating agent has been reported to cause transient increases in plasma ALT activity in some patients as well as rare instances of mucocutaneous skin reactions? Answer: Orally administered dimercaptosuccinic acid (DMSA) has been reported to cause transient increases in ALT activity as well as rare instances of mucocutaneous skin reactions. (Bradberry S et al. Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning. 2009 Q J Med 102:721-732) Thursday, December 1, 2016 Question: What is Clioquinol and why was it withdrawn from the market during the 1970s? Answer: According to the cited reference, “Between the 1950s and 1970s Clioquinol was used to treat and prevent intestinal parasitic disease [intestinal amebiasis].” “In the early 1970s Clioquinol was withdrawn from the market as an oral agent due to an association with sub-acute myelo-optic neuropathy (SMON) in Japanese patients. SMON is a syndrome that involves sensory and motor disturbances in the lower limbs as well as visual changes that are due to symmetrical demyelination of the lateral and posterior funiculi of the spinal cord, optic nerve, and peripheral nerves. -
Urticaria and Angioedema
Challenging Cases in Allergy and Immunology Massoud Mahmoudi Editor Challenging Cases in Allergy and Immunology Editor Massoud Mahmoudi D.O, Ph.D. RM (NRM), FACOI, FAOCAI, FASCMS, FACP, FCCP, FAAAAI Assistant Clinical Professor of Medicine University of California San Francisco San Francisco, California Chairman, Department of Medicine Community Hospital of Los Gatos Los Gatos, California USA ISBN 978-1-60327-442-5 e-ISBN 978-1-60327-443-2 DOI 10.1007/978-1-60327-443-2 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009928233 © Humana Press, a part of Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. -
Strengthening Poison Control Centres in the Region
REGIONAL COMMITTEE Provisional Agenda item 12 Fifty-second Session SEA/RC52/8 25 June 1999 STRENGTHENING POISON CONTROL CENTRES IN THE REGION TOWARDS SUSTAINABLE DEVELOPMENT THROUGH SOUND MANAGEMENT OF CHEMICALS SEA/RC52/8 CONTENTS Page 1. INTRODUCTION 1 2. PROBLEM OF EXPOSURE TO TOXIC CHEMICALS 1 3. EXISTING CAPACITIES FOR POISON CONTROL 2 4. INTERNATIONAL POLICY FRAMEWORK IN POISON CONTROL 3 5. STRATEGIES PROPOSED FOR ESTABLISHING POISON CONTROL PROGRAMME 4 5.1 Political Commitment: Leading Role of Ministry of Health 4 5.2 Partnership with NGOs, Private Sectors and Other Disciplines 4 5.3 Prevention and Awareness Programme 5 5.4 Training and Education 5 5.5 Capacity Building and Institutional Strengthening 5 5.6 Support Role of IPCS/WHO and Centres of Excellence 5 6. SUMMARY AND CONCLUSIONS 6 7. POINTS FOR CONSIDERATION FOR IMPLEMENTATION OF THE STRATEGIES 7 7.1 Leading Role of Ministries of Health 7 7.2 Partnership with NGOs, Private Sector and Other Disciplines 7 7.3 Prevention and Awareness Programme 7 7.4 Training and Capacity Building 7 7.5 Role of WHO 8 SEA/RC52/8 1. INTRODUCTION The growing incidence of poisoning from accidental, occupational or intentional exposure to chemicals has drawn worldwide attention. While global incidence of poisoning is not known, it is estimated that up to half a million people die each year as a result of poisonings, due to pesticides and natural toxins. WHO conservatively estimated that though developing countries account for only 15% of the worldwide use of pesticides, about 50% of pesticide poisonings occur in these countries, especially through misuse of chemicals. -
Date: 1/9/2017 Question: Botulism Is an Uncommon Disorder Caused By
6728 Old McLean Village Drive, McLean, VA 22101 Tel: 571.488.6000 Fax: 703.556.8729 www.clintox.org Date: 1/9/2017 Question: Botulism is an uncommon disorder caused by toxins produced by Clostridium botulinum. Seven subtypes of botulinum toxin exist (subtypes A, B, C, D, E, F and G). Which subtypes have been noted to cause human disease and which ones have been reported to cause infant botulism specifically in the United States? Answer: According to the cited reference “Only subtypes A, B, E and F cause disease in humans, and almost all cases of infant botulism in the United States are caused by subtypes A and B. Botulinum-like toxins E and F are produced by Clostridium baratii and Clostridium butyricum and are only rarely implicated in infant botulism” (Rosow RK and Strober JB. Infant botulism: Review and clinical update. 2015 Pediatr Neurol 52: 487-492) Date: 1/10/2017 Question: A variety of clinical forms of botulism have been recognized. These include wound botulism, food borne botulism, and infant botulism. What is the most common form of botulism reported in the United States? Answer: According to the cited reference, “In the United States, infant botulism is by far the most common form [of botulism], constituting approximately 65% of reported botulism cases per year. Outside the United States, infant botulism is less common.” (Rosow RK and Strober JB. Infant botulism: Review and clinical update. 2015 Pediatr Neurol 52: 487-492) Date: 1/11/2017 Question: Which foodborne pathogen accounts for approximately 20 percent of bacterial meningitis in individuals older than 60 years of age and has been associated with unpasteurized milk and soft cheese ingestion? Answer: According to the cited reference, “Listeria monocytogenes, a gram-positive rod, is a foodborne pathogen with a tropism for the central nervous system. -
AN ANALYSIS of the MINAMATA CONVENTION on MERCURY and ITS IMPLICATIONS for the REGULATION of MERCURY in SOUTH AFRICA by James Co
AN ANALYSIS OF THE MINAMATA CONVENTION ON MERCURY AND ITS IMPLICATIONS FOR THE REGULATION OF MERCURY IN SOUTH AFRICA By James Connor Ross (210533584) Submitted in part fulfilment of the requirements for the degree of Master of Laws in Environmental Law (LLM) in the School of Law at the University of KwaZulu Natal Supervisor: Professor Michael Kidd June 2017 1 DECLARATION I, JAMES CONNOR ROSS, declare that The research reported in this dissertation, except where otherwise indicated, is my original work. This dissertation has not been submitted for any degree or examination at any other university. This dissertation does not contain other persons’ writing, unless specifically acknowledged as being sourced from other researchers. Where other written sources have been quoted, then: their words have been re-written but the general information attributed to them has been referenced; where their exact words have been used, their writing has been placed inside quotation marks, and referenced. This dissertation does not contain text, graphics or tables copied and pasted from the Internet, unless specifically acknowledged, and the source being detailed in the dissertation and in the References sections. Signed: ____________________ Date: ____________________ JAMES CONNOR ROSS As the candidate’s Supervisor I agree to the submission of this dissertation. ____________________ Date: ____________________ MICHAEL KIDD Professor, School of Law, University of KwaZulu-Natal, Howard College. 2 CONTENTS TITLE PAGE DECLARATION CHAPTER 1: Introduction and Background -
Processing Parameters Needed to Control Pathogens in Cold-Smoked Fish
Processing Parameters Needed to Control Pathogens in Cold-Smoked Fish A Report of the Institute of Food Technologists for the Food and Drug Administration of the U.S. Department of Health and Human Services submitted March 29, 2001 IFT/FDA Contract No. 223-98-2333 Task Order 2 Processing Parameters Needed to Control Pathogens in Cold-smoked Fish Table of Contents Preface ........................................................................ S-1058 7. Conclusions ....................................................................... S-1079 8. Research needs ................................................................. S-1079 Science Advisory Board .......................................... S-1058 References ............................................................................. S-1080 Scientific and Technical Panel ............................... S-1058 Chapter III. Potential Hazards in Cold-Smoked Fish: Clostridium botulinum type E Reviewers .................................................................. S-1058 Scope ...................................................................................... S-1082 1. Introduction ....................................................................... S-1082 Additional Acknowledgments ............................... S-1058 2. Prevalence in water, raw fish, and smoked fish .............. S-1083 3. Growth in refrigerated smoked fish ................................. S-1083 Background ...............................................................S-1059 4. Effect of processing