Natural Agents Affecting Excitatory and Inhibitory Neurotransmission

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Natural Agents Affecting Excitatory and Inhibitory Neurotransmission Adenosine Receptor Glycine Receptor Antagonists: K Channel Antagonists: Na Channel Agents: Antagonists: • Oenanthe fistulosa (Water Dropwort) [Toxin] • Cicutoxin/Cicuta maculata (Water • Aconitine/Aconitum spp • Caffeine • Strychnine/Strychnos Nux Vomica Hemlock) AND Cicuta Virosa (Monkshood/Wolfsbane) (Cowbane or Northern Water Hemlock) • Taxine/Taxus (Yew) Ca Cl Cl Na Adenosine Adenosine Glycine DA/NE/E/S PRE-SYNAPTIC POST-SYNAPTIC K + Glutamate Other Glutamate GABA (NMDA, KA) O PLP CO O Sympathomimetics: Na +/- Ca 2 Cl + + INHIBITORY NEURON • Cathinones (Khat/Qat) H3N H3N O- O- • Cocaine/Coca Glutamic acid • Ephedra/Ephedra spp. (Ma Huang) EXCITATORY NEURON-O O decarboxylase Competitive Non-competitive • Synanceia (Stonefish) [Toxin] Glutamate Agonists: Glutamate GABA Antagonists: Antagonists: • β-N-oxalylamino-L-alanine • Bicuculline/Dicentra • Anisatin/Illicium anisatum Serotonergics: (BOAA)/Lathyrus Sativa cucullaria (Dutchman's (Japanese star anise) GAD Inhibitors: breeches) • Cicutoxin & Virol A/ Cicuta • Hypericum perforatum/ St. (Chickling Pea) • Cyanide/cyanogenic glycosides • Colchicine/Colchicum maculata (Water Hemlock) AND John's Wort • Domoic Acid/Pseudo-nitzschia australis [Amnestic Shellfish [Stonefruit] autumnale (Autumn crocus) Cicuta Virosa (Cowbane or Poisoning] • Domoic Acid/Pseudo-nitzschia • Oenanthe fistulosa (Water Northern Water Hemlock) • Ibotenic Acid/Amanita Muscaria australis [Amnestic Shellfish Dropwort) [Toxin] *Probably • Picrotoxin/Anamirta cocculus (Fly Agaric) Poisoning] competitive (Fishberries) • Kainic Acid/Digenea simplex • Gyromitrin/Gyromitra Esculenta • Thujone/Artemisia absinthium (species of seaweed) (False Morel) (Wormwood) • Kainic Acid/Digenea simplex (species of seaweed) GABA site Agonists Antagonists Barbiturate site Depressants (also ethanol?) Cl ACh Excitants? Benzodiazepine site Agonists (depressants) Antagonists Inverse agonists Steroid site Nicotinic: Unknown: Anesthetics Excitants? • Nicotine/Coniine/ conium • Camphor/Cinnamomum camphora maculatum/Nicotiana spp./etc Adapted from http://www.ncbi.nlm.nih.gov/books/ Picrotoxin site NVK28090/figure/A1185/?report=objectonly Chloride Channel Convulsants Depressants?.

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XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 26–29 May 2015, St Julian's, Malta
Clinical Toxicology ISSN: 1556-3650 (Print) 1556-9519 (Online) Journal homepage: http://www.tandfonline.com/loi/ictx20 XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 26–29 May 2015, St Julian's, Malta To cite this article: (2015) XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 26–29 May 2015, St Julian's, Malta, Clinical Toxicology, 53:4, 233-403, DOI: 10.3109/15563650.2015.1024953 To link to this article: http://dx.doi.org/10.3109/15563650.2015.1024953 Published online: 26 Mar 2015. Submit your article to this journal Article views: 3422 View related articles View Crossmark data Citing articles: 2 View citing articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=ictx20 Download by: [UPSTATE Medical University Health Sciences Library] Date: 28 December 2016, At: 10:31 Clinical Toxicology (2015), 53, 233–403 Copyright © 2015 Informa Healthcare USA, Inc. ISSN: 1556-3650 print / 1556-9519 online DOI: 10.3109/15563650.2015.1024953 ABSTRACTS XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 26–29 May 2015, St Julian ’ s, Malta 1. Modelling dose-concentration-response Introduction: The American Association of Poison Control Cen- ters (AAPCC) published its fi rst annual report in 1983. Call data Ursula Gundert-Remy from sixteen US poison centers was chronicled in that report. Seven submitted data for the entire year. By July 2000, 63 centers Institute for Clinical Pharmacology and Toxicology, Charit é were part of the national poison center system, but only 59 submit- Medical School, Berlin, Germany ted data for the full year.
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