Glossary Terms
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Annual Conference Online 2021
CANDIDAANNUAL CONFERENCEAND ONLINECANDIDIASIS 2021 2021 21–27 March 2021 POSTER ABSTRACT BOOK #Candida2021 001A Candida auris gene expression: modulation upon caspofungin treatment Lysangela Alves1, Rafaela Amatuzzi1, Daniel Zamith-Miranda2, Sharon Martins1, Joshua Nosanchuk2 1Carlos Chagas Institute, Curitiba, Brazil. 2Departments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology, Albert Einstein College of Medicine, New York, USA Abstract Candida auris has emerged as a serious worldwide threat by causing invasive infections in humans that are frequently resistant to one or more conventional antifungal medications, resulting in high mortality rates. Against this backdrop, health warnings around the world have focused efforts on understanding C. auris fungal biology and effective treatment approaches to combat this fungus. To date, there is little information about C. auris gene expression regulation in response to antifungal treatment. Our integrated analyses focused on the comparative transcriptomics of C. auris in the presence and absence of caspofungin as well as a detailed analysis of the yeast’s extracellular vesicle (EV)-RNA composition. The results showed that genes coding oxidative stress response, ribosomal proteins, cell wall, and cell cycle were significantly up-regulated in the presence of caspofungin, whereas transcriptional regulators and proteins related to nucleus were down-regulated. The mRNAs in the EVs were associated with the stress responses induced by caspofungin and the ncRNA content of the EVs shifted during caspofungin treatment. Altogether, the results provide further insights into the fungal response to caspofungin and demonstrate that analyses of C. auris growth under antifungal stress can elucidate resistance and survival mechanisms of this fungus in response to medical therapy. -
Phylogenetic Relationships of the Genus Frenkelia
International Journal for Parasitology 29 (1999) 957±972 Phylogenetic relationships of the genus Frenkelia: a review of its history and new knowledge gained from comparison of large subunit ribosomal ribonucleic acid gene sequencesp N.B. Mugridge a, D.A. Morrison a, A.M. Johnson a, K. Luton a, 1, J.P. Dubey b, J. Voty pka c, A.M. Tenter d, * aMolecular Parasitology Unit, University of Technology, Sydney NSW, Australia bUS Department of Agriculture, ARS, LPSI, PBEL, Beltsville MD, USA cDepartment of Parasitology, Charles University, Prague, Czech Republic dInstitut fuÈr Parasitologie, TieraÈrztliche Hochschule Hannover, BuÈnteweg 17, D-30559 Hannover, Germany Received 3 April 1999; accepted 3 May 1999 Abstract The dierent genera currently classi®ed into the family Sarcocystidae include parasites which are of signi®cant medical, veterinary and economic importance. The genus Sarcocystis is the largest within the family Sarcocystidae and consists of species which infect a broad range of animals including mammals, birds and reptiles. Frenkelia, another genus within this family, consists of parasites that use rodents as intermediate hosts and birds of prey as de®nitive hosts. Both genera follow an almost identical pattern of life cycle, and their life cycle stages are morphologically very similar. How- ever, the relationship between the two genera remains unresolved because previous analyses of phenotypic characters and of small subunit ribosomal ribonucleic acid gene sequences have questioned the validity of the genus Frenkelia or the monophyly of the genus Sarcocystis if Frenkelia was recognised as a valid genus. We therefore subjected the large subunit ribosomal ribonucleic acid gene sequences of representative taxa in these genera to phylogenetic analyses to ascertain a de®nitive relationship between the two genera. -
New Zealand's Genetic Diversity
1.13 NEW ZEALAND’S GENETIC DIVERSITY NEW ZEALAND’S GENETIC DIVERSITY Dennis P. Gordon National Institute of Water and Atmospheric Research, Private Bag 14901, Kilbirnie, Wellington 6022, New Zealand ABSTRACT: The known genetic diversity represented by the New Zealand biota is reviewed and summarised, largely based on a recently published New Zealand inventory of biodiversity. All kingdoms and eukaryote phyla are covered, updated to refl ect the latest phylogenetic view of Eukaryota. The total known biota comprises a nominal 57 406 species (c. 48 640 described). Subtraction of the 4889 naturalised-alien species gives a biota of 52 517 native species. A minimum (the status of a number of the unnamed species is uncertain) of 27 380 (52%) of these species are endemic (cf. 26% for Fungi, 38% for all marine species, 46% for marine Animalia, 68% for all Animalia, 78% for vascular plants and 91% for terrestrial Animalia). In passing, examples are given both of the roles of the major taxa in providing ecosystem services and of the use of genetic resources in the New Zealand economy. Key words: Animalia, Chromista, freshwater, Fungi, genetic diversity, marine, New Zealand, Prokaryota, Protozoa, terrestrial. INTRODUCTION Article 10b of the CBD calls for signatories to ‘Adopt The original brief for this chapter was to review New Zealand’s measures relating to the use of biological resources [i.e. genetic genetic resources. The OECD defi nition of genetic resources resources] to avoid or minimize adverse impacts on biological is ‘genetic material of plants, animals or micro-organisms of diversity [e.g. genetic diversity]’ (my parentheses). -
Membrane Phase Miscibility Gaps and Surface Constraints
SurfaceMembrane constraints phase miscibility and membrane gaps and phase surface miscibility constraints gaps W.A. Hamilton,1 L. Porcar1,2 and G.S. Smith3,1 1 Neutron Scattering Center, Oak Ridge National Laboratory 2 NIST Center for Neutron Research 3 LANSCE, Los Alamos National Laboratory Research supported by the US Department of Energy, Division of Materials Science 2nd American Conference on Neutron Scattering, College Park MD 6-10 June 2004 Self-assembled surfactant membrane phase: L3 “sponge” phase δ ~ 20-30Å bilayer membrane surfactant molecule d ~ 100 –1000 Å 3 “oily-salt” QuartzA surface very fluid aqueous phase over? wide dilution Potentially useful as a mixing stage in (membrane) protein crystallization for structural characterization and as template phaseOur for simply high porosityconstraining structures proximate (as surface per aerogels ... ) What does an isotropic bulk phase do in an anisotropic situation? Same in all directions - manifestly isotropic - so ... A nearby answer in the phase diagram … Generic membrane phase diagram region … A competition between curvature, topology and entropy e r Sponge - L u 3 t a v r ratio, salt d u I+L3 +… 3 hexanol c / c i s L3 n CPCl i r t or L3 + Lα biphasic - miscibility gap n cosurfactant i no single phase solution to competition here g n i s Lα Lamellar - L a α e AOT/brine r c Surfactant/ T ~1% ~50 % n i volume fraction φ dα Stacked lamellar phase would fit nicely against a constraining surface ... Near surface constraint contributes to F Expect local effect on phase transition and miscibility gap (Lα+L3 coexistence) Typical L3 and Lα SANS at highish volume fraction e.g. -
Miscibility in Solids
Name _________________________ Date ____________ Regents Chemistry Miscibility In Solids I. Introduction: Two substances in the same phases are miscible if they may be completely mixed (in liquids a meniscus would not appear). Substances are said to be immiscible if the will not mix and remain two distinct phases. A. Intro Activity: 1. Add 10 mL of olive oil to 10 mL of water. a) Please record any observations: ___________________________________________________ ___________________________________________________ b) Based upon your observations, indicate if the liquids are miscible or immiscible. Support your answer. ________________________________________________________ ________________________________________________________ 2. Now add 10 mL of grain alcohol to 10 mL of water. a) Please record any observations: ___________________________________________________ ___________________________________________________ b) Based upon your observations, indicate if the liquids are miscible or immiscible. Support your answer. ________________________________________________________ ________________________________________________________ Support for Cornell Center for Materials Research is provided through NSF Grant DMR-0079992 Copyright 2004 CCMR Educational Programs. All rights reserved. II. Observation Of Perthite A. Perthite Observation: With the hand specimens and hand lenses provided, list as many observations possible in the space below. _________________________________________________________ _________________________________________________________ -
Potential Drug Candidates Underway Several Registered Clinical Trials for Battling COVID-19
Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 20 April 2020 doi:10.20944/preprints202004.0367.v1 Potential Drug Candidates Underway Several Registered Clinical Trials for Battling COVID-19 Fahmida Begum Minaa, Md. Siddikur Rahman¥a, Sabuj Das¥a, Sumon Karmakarb, Mutasim Billahc* aDepartment of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi-6205, Bangladesh bMolecular Biology and Protein Science Laboratory, University of Rajshahi, Rajshahi-6205, Bangladesh cProfessor Joarder DNA & Chromosome Research Laboratory, University of Rajshahi, Rajshahi-6205, Bangladesh *Corresponding Author: Mutasim Billah, Professor Joarder DNA & Chromosome Research Laboratory, University of Rajshahi, Rajshahi, Bangladesh Corresponding Author Mail: [email protected] ¥Co-second author Abstract The emergence of new type of viral pneumonia cases in China, on December 31, 2019; identified as the cause of human coronavirus, labeled as "COVID-19," took a heavy toll of death and reported cases of infected people all over the world, with the potential to spread widely and rapidly, achieved worldwide prominence but arose without the procurement guidance. There is an immediate need for active intervention and fast drug discovery against the 2019-nCoV outbreak. Herein, the study provides numerous candidates of drugs (either alone or integrated with another drugs) which could prove to be effective against 2019- nCoV, are under different stages of clinical trials. This review will offer rapid identification of a number of repurposable drugs and potential drug combinations targeting 2019-nCoV and preferentially allow the international research community to evaluate the findings, to validate the efficacy of the proposed drugs in prospective trials and to lead potential clinical practices. Keywords: COVID-19; Drugs; 2019-nCoV; Clinical trials; SARS-CoV-2 Introduction A new type of viral pneumonia cases occurred in Wuhan, Hubei Province in China, on December 31, 2019; named "COVID-19" on January 12, 2020 by the World Health Organization (WHO) [1]. -
2019 Annual Report
2019 Annual Report 1 TABLE OF CONTENTS - 2 DEPARTMENT PHOTO - 3 MISSION - 4 PRIMARY FACULTY PROMOTIONS & DEPARTURES - 5 NEW APPOINTMENTS OF SECONDARY FACULTY-6 SECONDARY FACULTY DEPARTURES – 8 IN MEMORIAM – 9 FACULTY WITH PRIMARY APPOINTMENTS - 10 FACULTY WITH SECONDARY APPOINTMENTS - 21 FACULTY WITH EMERITUS APPOINTMENTS – 31 FACULTY WITH ADJUNCT APPOINTMENTS - 32 ADMINISTRATIVE STAFF - 32 NEW GRADUATE STUDENT CLASS – 33 GRADUATE STUDENTS – 36 GRADUATES– 37 FACULTY HONORS – 39 STUDENT HONORS - 40 PUBLICATIONS - 42 ABSTRACTS - 47 RESEARCH GRANTS ACTIVE - 59 RESEARCH GRANTS SUBMITTED - 68 INVITED SCIENTIFIC PRESENTATIONS - 76 INTELLECTUAL PROPERTY ACTIONS – 80 DEPARTMENTAL COURSES - 81 STANDING COMMITTEES – 82 NCI CANCER EDUCATION PROGRAM - 83 2 3 MISSION The Department of Pharmacology and Toxicology will ensure academic excellence and achievement of regional, national, and international recognition for the quality of its educational, research, and service activities. Guided by the University of Louisville and the School of Medicine Strategic Plans, the mission of the Department of Pharmacology and Toxicology focuses on five broad objectives: • Provide instruction in pharmacology and toxicology of the highest quality for the education and preparation of medical, dental, and other health care professional students. Emphasis is placed on the fundamental principles necessary for life-long learning and the essential knowledge required for rational, effective, and safe use of drug therapy. • Advance biomedical knowledge through high quality research and other scholarly activities, particularly in pharmacology and toxicology and other areas of focus within the University of Louisville and School of Medicine Strategic Plans. • Provide robust research and educational experiences in pharmacology and toxicology for the education and training of future biomedical scientists who will provide and advance biomedical education, research, and service. -
Contact Melting and the Structure of Binary Eutectic Near the Eutectic Point
Contact melting and the structure of binary eutectic near the eutectic point Bystrenko O.V. 1,2 and Kartuzov V.V. 1 1 Frantsevich Institute for material sсience problems, Kiev, Ukraine, 2 Bogolyubov Institute for theoretical physics, Kiev, Ukraine Abstract. Computer simulations of contact melting and associated interfacial phenomena in binary eutectic systems were performed on the basis of the standard phase-field model with miscibility gap in solid state. It is shown that the model predicts the existence of equilibrium three-phase (solid-liquid-solid) states above the eutectic temperature, which suggest the explanation of the phenomenon of phase separation in liquid eutectic observed in experiments. The results of simulations provide the interpretation for the phenomena of contact melting and formation of diffusion zone observed in the experiments with binary metal-silicon systems. Key words: phase field, eutectic, diffusion zone, phase separation 1. Introduction. Phenomenon of contact (eutectic) melting (CM) is rather common for multicomponent systems and has important industrial implications [1], which motivate its experimental and theoretical studies. The aim of this work is a theoretical study of the properties of CM in binary eutectic systems and the interpretation of the results of recent experiments particularly focused on the investigation of the interfacial phenomena associated with CM [2, 3]. In these experiments, the binary systems consisting of metal Au, Al, Ag, and Cu particles (of 5 10-6 m size) placed on amorphous or crystalline -
Tyrosinase Inhibitors from Traditional Chinese Medicine As Potential Anti-Hyperpigmentation Agents
Tyrosinase Inhibitors from Traditional Chinese Medicine as Potential Anti-hyperpigmentation agents Author Shi, Gengxuan Published 2019 Thesis Type Thesis (Masters) School School of Environment and Sc DOI https://doi.org/10.25904/1912/1780 Copyright Statement The author owns the copyright in this thesis, unless stated otherwise. Downloaded from http://hdl.handle.net/10072/387690 Griffith Research Online https://research-repository.griffith.edu.au Tyrosinase Inhibitors from Traditional Chinese Medicine as Potential Anti-hyperpigmentation agents Gengxuan SHI School of Environment and Science Griffith Science Griffith University Submitted in fulfilment of the requirements of the degree of Master of Science July 2019 i Abstract Several treatments for skin pigmentation are available today, however, many have unwanted side effects. Classic drugs like hydroquinone, arbutin, mequinol and kojic acid have been considered strongly carcinogenic, with related adverse effects. Traditional Chinese medicines (TCMs) have long been documented for their skin- lightening properties with little known negative effects. However, little is known about precisely how these herbal medicines work and what are the chemical basis for their activity. In this project, a 96-well plate based tyrosinase assay was established and used to test 44 TCM with known skin-lightening properties. Out of 44, 17 TCM extracts showed over 60% inhibition against tyrosinase at the concentration of 0.5 mg/mL. One of the TCM extracts, Xanthium strumarium L. extract, possessed 81.7% inhibition at 0.5 mg/mL. Further bioassay-guided isolation of the crude extract resulted in 10 compounds. Three of the compounds showed moderate activity against tyrosinase with IC50 values of 0.18 mM (cytidine), 0.29 mM (1,4-dicaffeoylquinic acid) and 2.47 mM (xanthiside). -
Comparison of Transport Fuels
COMPARISON OF TRANSPORT FUELS FINAL REPORT (EV45A/2/F3C) to the AUSTRALIAN GREENHOUSE OFFICE on the Stage 2 study of Life-cycle Emissions Analysis of Alternative Fuels for Heavy Vehicles By Tom Beer1,2, Tim Grant3, Geoff Morgan4, Jack Lapszewicz5, Peter Anyon6, Jim Edwards7, Peter Nelson7, Harry Watson8 & David Williams7 1 CSIRO Atmospheric Research, Aspendale, Vic. 2 CSIRO Environmental Risk Network, Aspendale, Vic. 3 RMIT Centre for Design, Melbourne, Vic. 4 Southern Cross Institute of Health Research, Lismore, NSW 5 CSIRO Energy Technology, Lucas Heights, NSW 6 Parsons Australia Pty Ltd 7 CSIRO Energy Technology, North Ryde, NSW 8 University of Melbourne, Department of Mechanical and Manufacturing Engineering, Parkville, Vic. in association with and Parsons Australia Pty Ltd Southern Cross Institute of Health Research Contact Dr Tom Beer Co-ordinator CSIRO Environmental Risk Network Private Bag 1 Aspendale, Vic. 3195 Australia Phone: (03) 9239 4400 Fax: (03) 9239 4444 International: + 613 9239 4400 Fax +613 9239 4444 e-mail: [email protected] EV45A_2P0_F3C_Part0 ii Table of Contents Acronyms..................................................................................................................................ix Glossary of Terms ....................................................................................................................xii Executive Summary..................................................................................................................xv Part 1 1. Background.....................................................................................................................1 -
Radiation and Climate
m ^ <(. -Zc'.^.^Z l INTERNATIONAL COUNCIL OF WORLD METEOROLOGICAL SCIENTIFIC UNIONS ORGANIZATION RADIATION AND CLIMATE SECOND WORKSHOP ON IMPLEMENTATION OF THE BASELINE SURFACE RADIATION NETWORK (Davos, Switzerland, 6-9 August 1991) NOVEMBER 1991 WCRP-64 WMO/TD-No. 453 ) i t 'I The World Climate Programme launched by the World Meteorological Organization (WMO) includes four components: The World Climate Data and Monitoring Programme The World Climate Applications and Services Programme The World Climate Impact Assessment and Response Strategies Programme The World Climate Research Programme The World Climate Research Programme is jointly sponsored by the WMO and the International Council of Scientific Unions. I NOTE The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Meteorological Organizaüon concerning the legal status of any country, territory, city or area, or of its authoriues, or concerning the delimitation of its frontiers or boundaries. This report has been produced without editorial revision by the WMO Secretariat. It is not an official publication and its distribution in this form does not imply endorsement by the Organization of the ideas expressed. R. t; TABLE OF CONTENTS Page No. l. OBJECTIVES OF WORKSHOP l 2. REPORTS ON INSTRUMENTATION AND MEASUREMENT UNCERTAINTY STUDIES 2 3. RECOMMENDATIONS FOR DETERMINATION OF BASIC BSRN PARAMETERS AND BSKN OPERATIONAL PROCEDURES 8 '9^ 3.l Instruments and methods 8 •i:'K.'"- 3.2 Calibration procedures 11 3.3 Data acquisition 12 3.4 Measurement uncertainty techniques 13 3.5 Preparation of operations manual for the BSRN 13 4. -
Summary and Interpretation of Dye-Tracer Tests to Investigate The
SUMMARY AND INTERPRETATION OF DYE-TRACER TESTS TO INVESTIGATE THE HYDRAULIC CONNECTION OF FRACTURES AT A RIDGE-AND-VALLEY- WALL SITE, NEAR FISHTRAP LAKE, PIKE COUNTY, KENTUCKY By Charles J. Taylor U.S. GEOLOGICAL SURVEY Water-Resources Investigations Report 94-4189 Prepared in cooperation with the U.S. OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT Louisville, Kentucky 1994 U.S. DEPARTMENT OF THE INTERIOR BRUCE BABBITT, Secretary U.S. GEOLOGICAL SURVEY Gordon P. Eaton, Director For additional information write to: Copies of this report can be purchased from: District Chief U.S. Geological Survey U.S. Geological Survey Earth Science Information Center District Office Open-File Reports Section 2301 Bradley Avenue Box 25286, MS 517 Louisville, KY 40217 Denver Federal Center Denver, CO 80225 CONTENTS Abstract............................................................................................~^ 1 Introduction.........................................................................._^ Purpose and scope.......................................................................................................................................................3 Description of study site............................................................................................................................................. 3 Geologic setting ...................................................................................................................................................3 Hydrogeologic framework...................................................................................................................................5