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Mitochondrial Medicine 2019: Washington DC Scientific and Clinical Meetings June 26-29, 2019 Hilton Alexandria Mark Center Alexandria, VA

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Mitochondrial Medicine 2019: Washington DC Scientific and Clinical Meetings June 26-29, 2019 Hilton Alexandria Mark Center Alexandria, VA Mitochondrial Medicine 2019: Washington DC Scientific and Clinical Meetings June 26-29, 2019 Hilton Alexandria Mark Center Alexandria, VA 2019 Course Chairs: Amel Kara, MD and Carla Koehler, PhD 2019 CME Chair: Bruce H. Cohen, MD Mitochondrial Medicine 2019: Washington DC Scientific/Clinical Program June 26-29, 2019 Course Description The United Mitochondrial Disease Foundation and PeerPoint Medical Education Institute have joined efforts to sponsor and organize a CME-accredited symposium. Mitochondrial diseases are more common than previously recognized and mitochondrial pathophysiology is now a recognized part of many disease processes, including heart disease, cancer, AIDS and diabetes. There have been significant advances in the molecular genetics, proteomics, epidemiology and clinical aspects of mitochondrial pathophysiology. This conference is directed toward the scientist and clinician interested in all aspects of mitochondrial science. The content of this educational program was determined by rigorous assessment of educational needs and includes surveys, program feedback, expert faculty assessment, literature review, medical practice, chart review and new medical knowledge. The format will include didactic lectures from invited experts intermixed with peer-reviewed platform presentations. There will be ample time for professional discussion both in and out of the meeting room, and peer-reviewed poster presentations will be given throughout the meeting. This will be a four-day scientific meeting aimed at those with scientific and clinical interests. TARGET AUDIENCE Neurologists, Geneticists, Researchers/Scientists, Pediatrics, Internal Medicine, Nephrologists, Cardiologists, Endocrinologists, Genetic Counselors, Advanced Practice Nurses, Physicians Assistants, RNs, Occupational Therapy, Physical Therapy and Speech-Language Pathology, Nutritional Therapy, and Residents/Fellows/Students. LEARNING OBJECTIVES • Learn about new clinical trials investigating treatments for mitochondrial diseases in children and adults • Become familiar with new insights the technology of mitochondrial transfer as it relates to possible treatment for mitochondrial disease. • Learn how the use of true Whole Genome Sequencing can be applied to diagnose mitochondrial diseases • Summarize the development of consortium-based discovery and care networks are changing the face of clinical practice as it relates to mitochondrial medicine. • Discover the role of the US Food and Drug Administration in the approval process for treatments of rare diseases including mitochondrial disease. • Understand the application of iPS cells for Leigh syndrome diagnostics and possible therapy • Describe the interactions between mitochondrial and the microbiota. • Learn about innate immunity and the role of the mitochondria in innate immunity and immunity in those with known mitochondrial diseases. • Learn of the advances in the understanding of organelle cross-talk and mitochondrial Specialdynamics Announcements • Discover the role of mitochondrial epigenetics and the process of DNA Name Badgesmethylation of the mtDNA All attendees must wear a name badge to all course functions. ACCREDITATION STATEMENT Scientific Sessions Majority of scientific sessions will be held in Plaza A. On Friday morning, sessions will begin in PlazaThis Cactivity through has 10:00am been plannedbreak and and will implementedresume in Plaza in A.accordance On Saturday with morning, the accreditation the MSeqDR Workshoprequirements session and will policies be in Beech of the from Accreditation 7:15am to 7:45am Council but for the Continuing general scientific Medical session Education will (ACCME) through the joint providership of PeerPoint Medical Education Institute, LLC begin at 8:00am in Plaza A. and United Mitochondrial Disease Foundation. The PeerPoint Medical Education RefreshmentInstitute, LLC Breaks is accredited/Exhibits/Posters by the ACCME to provide continuing medical education for Exhibitsphysicians. will be open in the Plaza Foyer during all breaks and lunches. Posters will be in Arbors Room. All posters are assigned numbers in the back of this syllabus. Presenters will station themselvesDESIGNATION at their STATEMENTposter to field questions according to those numbers as follows: even numbers on Wednesday from 5:30 pm to 7:30 pm and odd numbers on Thursday from 5:30 pm to 7:30 pm. If a TheLightning PeerPoint Round Medical person speaksEducation on Wednesday, Institute, LLC they designates will station themselvesthis live activity at their for poster a on Wednesdaymaximum eveningof 18.50 (regardless AMA PRA of Category poster number). 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity. Meals Continental Breakfasts and Lunches will be held in Plaza C. Special Announcements Abstract Cash Awards will be presented on Friday, June 28 at 4:45pm in Plaza A. CME Certificate Instructions Attendees for this year’s meeting will generate their own CME Certificate through the PeerPoint CME Vault online system. Post meeting, you will receive an email within a week with instructions on how to access the CME Vault and secure your certificate. NOTE: Peerpoint will set up your login identities based on the information you confirmed at registration upon check-in. If you did not confirm and initial your information, please do so before you leave the meeting this week. Each attendee must have a unique email address; groups or partners cannot share an email address to access the CME Vault. Make sure you check your spam folders for emails coming from peerpt.com. For general information about PeerPoint, visit http://www.peerpt.com. Special Announcements Name Badges All attendees must wear a name badge to all course functions. Scientific Sessions Majority of scientific sessions will be held in Plaza A. On Friday morning, sessions will begin in Plaza C through 10:00am break and will resume in Plaza A. On Saturday morning, the MSeqDR Workshop session will be in Beech from 7:15am to 7:45am but the general scientific session will begin at 8:00am in Plaza A. Refreshment Breaks/Exhibits/Posters Exhibits will be open in the Plaza Foyer during all breaks and lunches. Posters will be in Arbors Room. All posters are assigned numbers in the back of this syllabus. Presenters will station themselves at their poster to field questions according to those numbers as follows: even numbers on Wednesday from 5:30 pm to 7:30 pm and odd numbers on Thursday from 5:30 pm to 7:30 pm. If a Lightning Round person speaks on Wednesday, they will station themselves at their poster on Wednesday evening (regardless of poster number). Meals Continental Breakfasts and Lunches will be held in Plaza C. Special Announcements Abstract Cash Awards will be presented on Friday, June 28 at 4:45pm in Plaza A. CME Certificate Instructions Attendees for this year’s meeting will generate their own CME Certificate through the PeerPoint CME Vault online system. Post meeting, you will receive an email within a week with instructions on how to access the CME Vault and secure your certificate. NOTE: Peerpoint will set up your login identities based on the information you confirmed at registration upon check-in. If you did not confirm and initial your information, please do so before you leave the meeting this week. Each attendee must have a unique email address; groups or partners cannot share an email address to access the CME Vault. Make sure you check your spam folders for emails coming from peerpt.com. For general information about PeerPoint, visit http://www.peerpt.com. 2019 Scientific/Clinician Meeting – Faculty • 2019 Scientific Meeting – Confirmed Faculty o Dario C. Altieri, MD, Wistar Institute Cancer Center, Philadelphia, PA o Ana Andreazza, PhD, University of Toronto, Toronto, Canada o Brendan Battersby, PhD, University of Helsinki, Institute of Biotechnology, Finland o William Copeland, PhD, NIEHS, Research Triangle Park, NC o Patrick Chinnery, PhD, FRCP, University of Cambridge, Cambridge, United Kingdom o David Dimmock, MD, Rady Children’s Institute for Genomic Medicine, San Diego, CA o Amy Goldstein, MD, Children’s Hospital of Philadelphia, Philadelphia, PA o Michio Hirano, MD, Columbia University, New York, NY o Adam Hughes, PhD, University of Utah School of Medicine, Salt Lake City, UT o Shilpa Iyer, PhD, University of Arkansas, Fayetteville, AR o Amel Karaa, MD, Massachusetts General Hospital, Boston, MA o Carla Koehler, PhD, University of California Los Angeles, Los Angeles, CA o Mary Kay Koenig, MD, University of Texas McGovern Medical School, Houston, TX o Danuta Krotoski, PhD, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD o Austin Larson, MD, Children’s Hospital Colorado, Denver, CO o David J. Livingston, PhD, Brown University, Providence, RI o David Lynch, MD, PhD, Children’s Hospital of Philadelphia, Philadelphia, PA o Peter McGuire, MS, MBBCh, Metabolism, Infection and Immunity Section, National Human Genome Research Institute, NIH, Bethesda, MD o Vamsi K. Mootha, MD, Harvard Medical School, Boston, MA o Sumit Parikh, MD, The Cleveland Clinic, Cleveland, OH o Anne Pariser, MD, NIH/National Center for Advancing Translational Sciences (NCATS), Bethesda, MD o William Prinz, PhD, NIH/National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD o Shamima Rahman, MA, BMBCh, PhD, FRCP, FRCPCH, Great Ormond Street Hospital and the National Hospital for Neurology, London, UK o David Shackelford,
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