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FINAL-ACTC-2020-V3-Programme CONTENTS Item Page About ACTC 2020 3 Conference Timetable 4 Welcome Message 6 Keynote Speakers 7 Roundtable Discussion 15 Advanced Skin & Respiratory Models 22 Abstracts Animal Free Research 25 Diabetes and Other Age-Related Disorders 27 Abstracts In Vitro Cancer Research Abstracts 30 In Vitro Models for Animal Replacement 33 Abstracts Advanced Cell Culture, 3D, Flow, Co-Culture 39 Abstracts Advanced Neurological Models Abstracts 48 Sponsor / Exhibitor Information 51 2 Produced by Kirkstall Ltd, 2020. All information correct at time of going to press. ABOUT ACTC 2020 Following the success of the 11th annual Advances in Cell and Tissue Culture conference in Cardiff last year, ACTC 2020 will be hosted as a virtual conference due to COVID. ACTC 2020 - will take place over two days on Wednesday 30th September & Thursday 1st October as a virtual event. The conference offers a great networking opportunity, bringing together industry and academic researchers working in all areas of in vitro cell culture to exchange knowledge, promote their activities and set up new collaborative projects. The programme for ACTC 2020 covers a wide range of interesting, relevant topics with a great line-up of keynote speakers anticipated. Session topics include: • Advanced Skin & Respiratory Models • Novel Models for Studying Neurological Diseases • In Vitro Models for Animal Replacement • Developments within In Vitro Cancer Research • Advanced Cell Culture; 3D, Fluid Flow & Co-culture • Diabetes and other age-related disorders • Animal Free Research 3 Produced by Kirkstall Ltd, 2020. All information correct at time of going to press. Conference Timetable Day 1 Produced by Kirkstall Ltd, 2020. All information correct at time of going to press. 4 Conference Timetable Day 2 5 Produced by Kirkstall Ltd, 2020. All information correct at time of going to press. WELCOME MESSAGE Welcome to the 12th Conference in the series on Advances in Cell and Tissue Culture and the first to be held as a virtual event. Despite the great challenges of working under the threat of COVID, it is great to see that we have been able to maintain the content in an interesting technical programme . The on line format includes some newly developed features so that you can interact with questions and comments as the event proceeds. It will not be quite our usual ‘Gordon Style’ event but there are lots of contributions from young researchers and it is really important for them to have an opportunity to present their work. The new on-line meeting tools are both a challenge and an opportunity. It looks like virtual meetings will be part of our lives for some considerable time to come and there are some real benefits. Most of the presentations have been pre-recorded and downloaded so we have no worries about our presenters getting stuck in airports or in traffic! We have also saved time and expense by not having to travel so it is well worth mastering the new paradigm. We wish to thank the team behind the scenes that have made all this happen together with all the contributors, session chairs, sponsors and exhibitors. Have a great time at the conference and don’t forget to tell all your friends by Twitter or Facebook. Malcolm Conference Founding Chairman Director Kirkstall Ltd Visiting Professor, Department of Bioengineering, Sheffield University. Produced by Kirkstall Ltd, 2020. All information correct at time of going to press. 6 KEYNOTE SPEAKERS 7 Dr. Samuel Constant Epithelix 3D Human epithelial models to study SARS-CoV- 2 pathogenesis Dr. Samuel Constant is co-founder and Chief Executive Officer of Epithelix (http://www.epithelix.com) and OncoTheis (http://www.oncotheis.com) two Swiss biotech companies specialized in tissue engineering. Epithelix is a leader for in vitro assessment of drug efficacy and toxicity on human respiratory tract. Epithelix has developed unique 3D in vitro human airway tissues and testing services for studying airway pathologies like Asthma, Cystic Fibrosis and Chronic Obstructive Pulmonary Diseases, Bacterial and Viral infections. Samuel is in charge of global management and business development of the company; he also deals with the external collaborations with private and public research groups. Since 2006, Dr. Samuel Constant and his teams have won 18 prizes for their scientific achievements, technological innovation, and business development. 8 Produced by Kirkstall Ltd, 2020. All information correct at time of going to press. Carla Owen Animal Free Research, UK Animal Free Research: A systemic approach to transForming biomedical research and regulation Carla Owen joined Animal Free Research UK in role of CEO in April 2018 after previously spending 10 years with Cruelty Free International. At Cruelty Free International Carla was their Director of Development, Marketing and Communications, where she led the development of a new brand, a high profile partnership with The Body Shop and facilitated a digital transformation programme 9 Produced by Kirkstall Ltd, 2020. All information correct at time of going to press. Prof. Lorna Harries Exeter University, UK Cellular stress and beta cell identity changes Professor Lorna Harries holds a personal chair in Molecular Genetics at the University of Exeter College of Medicine and Health. She gained her PhD in Genetics from University College London in November 1994 and has worked at a number of institutions including the University of Dundee and the University of Sussex. Lorna relocated to the South West of England in 2001 and established the RNA-mediated disease mechanisms group at the University of Exeter College of Medicine and Health in 2006. Her group has interests in Omics approaches to the study of human ageing and age- related disease processes in man with a specific current focus on alternative messenger RNA processing, non-coding RNA and epigenetic gene regulation. Her work ranges from ‘big data’ approaches (whole genome transcriptomics and epigenetics) to detailed individual molecular analysis of particular genes and encompasses assessment of effects at the molecular, cellular and systemic levels. Her group were the first to report dysregulation of splicing regulators in association with ageing and longevity in human populations, as well as in human models of cellular ageing and in animal models. The Harries team subseQuently demonstrated that targeting splicing regulation using small molecules or targeted genetic interventions was able to reverse features of cellular senescence in human cell systems and highlights splicing regulation as a potential point of therapeutic traction for age-related diseases. 10 Produced by Kirkstall Ltd, 2020. All information correct at time of going to press. Victoria Marsh Durban Cellesce, CardiFF, UK Making 3D possible: large scale organoid production using bioprocess design Victoria completed her Ph.D. at Cardiff University (UK) in 2008 in the field of cancer genetics, focussing on the development of models of gastrointestinal tract malignancies. She subsequently moved to the University of California, San Francisco where she held a postdoctoral research scholarship investigating targeted therapeutic approaches in malignant melanoma. In 2014, Vicky returned to Cardiff to take up a Research Fellowship at the European Cancer Stem Cell Research Institute. Since then, she has gained industrial research experience in a clinical-stage cell therapy company in the field of extracellular vesicle therapeutics, before joining Cellesce in 2019. 11 Produced by Kirkstall Ltd, 2020. All information correct at time of going to press. Helena Kanderova Slovak Academy oF Sciences, Slovakia Medical Devices Biocompatibility Testing in Vitro - Are We There Yet? Helena’s scientific interest is focusing on the development, validation and implementation of in vitro methods for reduction & replacement of in vivo tests for topical toxicity testing of chemicals, cosmetics, pesticides and medical devices. She has been involved or directly managed international projects aiming at the evaluation and validation of 3D reconstructed human tissue models replacing testing in animals. Helena completed her PhD thesis on the “Use of Reconstructed human tissue models in regulatory toxicology” in 2006 at Freie Universität in Berlin. Her PhD thesis was supported by ZEBET at the Federal Institute of Risk Assessment (BfR). After finishing her PhD, she joined MatTek Corporation, USA in 2007 in the position of Senior Scientist and General Acting Manager for EU and since 2009 - 2018 she also acted as Executive Director of MatTek In Vitro Life Science Laboratories, located in the EU. In 2019, Helena joined Centre of Experimental Medicine at the Slovak Academy of Science in the position of Senior Scientist. Helena is a board member of ESTIV, SETOX and SNP3Rs and member of several professional toxicology societies. She is member of editorial board of six toxicology-oriented journals. Helena actively contributes to dissemination of in vitro toxicology and concept of 3Rs via her work at the OECD expert committees and at national advisory committees (medical devices, alternative methods). She co-authored 45 publications and achieved more than 1000 cited references. She was president of the EUROTOX 2017 Congress and obtained several awards related to her research on topical toxicity testing in vitro. 12 Produced by Kirkstall Ltd, 2020. All information correct at time of going to press. Dr. John Connelly Queen Mary University oF London, UK Engineering vascularised and immune- responsive human skin equivalents via indirect
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