DOCSLIB.ORG

The Teratological Effects of Trimethadione and Diphenylhydantoin on Development in the CD-1 Mouse

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
The Teratological Effects of Trimethadione and Diphenylhydantoin on Development in the CD-1 Mouse INFORMATION TO USERS This reproduction was made from a copy of a document sent to us for microfilming. While the most advanced technology has been used to photograph and reproduce this document, the quality of the reproduction is heavily dependent upon the quality of the material submitted. The following explanation of techniques is provided to help clarify markings or notations which may appear on this reproduction. 1.The sign or “target” for pages apparently lacking from the document photographed is “Missing Page(s)”. If it was possible to obtain the missing page(s) or section, they are spliced into the film along with adjacent pages. This may have necessitated cutting through an image and duplicating adjacent pages to assure complete continuity. 2. When an image on the film is obliterated with a round black mark, it is an indication of either blurred copy because of movement during exposure, duplicate copy, or copyrighted materials that should not have been filmed. For blurred pages, a good image of the page can be found in the adjacent frame. If copyrighted materials were deleted, a target note will appear listing the pages in the adjacent frame. 3. When a map, drawing or chart, etc., is part of the material being photographed, a definite method of “sectioning” the material has been followed. It is customary to begin filming at the upper left hand comer of a large sheet and to continue from left to right in equal sections with small overlaps. If necessary, sectioning is continued again—beginning below the first row and continuing on until complete. 4. For illustrations that cannot be satisfactorily reproduced by xerographic means, photographic prints can be purchased at additional cost and inserted into your xerographic copy. These prints are available upon request from the Dissertations Customer Services Department. 5. Some pages in any document may have indistinct print. In all cases the best available copy has been filmed. University Microfilms International 300 N. Zeeb Road Ann Arbor, Ml 48106 8318458 Witkowski, Charles Edward, Sr. THE TERATOLOGICAL EFFECTS OF TRIMETHADIONE AND DIPHENYLHYDANTOIN ON DEVELOPMENT IN THE CD-I MOUSE The Ohio Stale University Ph.D. 1983 University Microfilms International300 N. Zeeb Road, Ann Arbor, MI 48106 Copyright 1983 by Witkowski, Charles Edward, Sr. All Rights Reserved PLEASE NOTE: In all cases this material has been filmed in the best possible way from the available copy. Problems encountered with this docum ent have been identified here with a check mark V . 1. Glossy photographs or pages^ 2. Colored illustrations, paper or____ print 3. Photographs with dark background^ 4. Illustrations are poor copy______ 5. Pages with black marks, not original ___copy 6. Print shows through as there is text on both sides_______ of page 7. Indistinct, broken or small print on several ____pages 8. Print exceeds margin requirements______ 9. Tightly bound copy with print lost______ in spine 10. Computer printout pages with indistinct______ print 11. Page(s)____________ lacking when material received, and not available from school or author. 12. Page(s)____________ seem to be missing in numbering only as text follows. 13. Two pages numbered____________ . Text follows. 14. Curling and wrinkled pages______ 15. Other________________________________________________________________________ University Microfilms International THE TERATOLOGICAL EFFECTS OF TRIMETHADIONE AND DIPHENYLHYDANTOIN ON DEVELOPMENT IN THE CD-I MOUSE DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Charles Edward Witkowski, Sr., B.S., M.S. & A A * A The Ohio State University 1983 Reading Committee: Approved By Thomas G. Hayes, Ph.D., Adviser Ronald L. St. Pierre, Ph.D. Adviser 0 Martha E. Sucheston, Ph.D. Department of Anatomy To my wife, LYNN my son, CHARLES II my daughter, ANDREA ii ACKNOWLEDGMENTS I would like to express my tremendous gratitude, admiration and respect to my adviser and Graduate Studies Committee Chairman, Dr. Thomas G. Hayes, for the excellent leadership, support, counsel and encouragement he has provided me. I am also thankful to Dr. Martha E. Sucheston for her guidance, understanding and sense of humor. Thankfulness is extended to the faculty, graduate students and staff of the Department of Anatomy for their interaction and sharing. I would also like to express thanks to Dr. Larry Sachs for his help and statistical expertise, to Karl Rubin for his incredible photographic skills and to Malinda Amspaugh for her technical assis­ tance. Special thanks to my wife, Lynn, for her endless hours of typing. Again, I would like to acknowledge my best friend and greatest supporter, my wife, Lynn. Thank you for sharing me and making education a priority. With your love, patience, understanding and total support, I was able to complete this endeavor for us and our family. To my son, Chuck, and daughter, Andrea, I would like to express my thanks for their love and understanding and for sharing me. A very special thanks go to my parents who have instilled in me the supreme importance of the value of an education. VITA NAME: Charles Edward Witkowski, Sr. DATE OF BIRTH: August 7, 1951 PLACE OF BIRTH: Mt. Carmel, Illinois MARITAL STATUS: Married: Wife - Patricia L. (Jordan) Witkowski Son - Charles E. Witkowski, II Daughter - Andrea L. Witkowski EDUCATION: Mt. Carmel High School, Mt. Carmel, Illinois 1969 University of Illinois, Urbana, Illinois B.S. 1973 Murray State University, Murray, Kentucky M.S. 1976 The Ohio State University, Columbus, Ohio Ph.D. 1983 The Ohio State University, Columbus, Ohio D . D. S. 1983 TEACHING AND ACADEMIC INSTRUCTION EXPERIENCE: Graduate Teaching Associate: The Ohio State University, College of Medicine, Department of Anatomy - 1976 - 1983 Subject Areas: Graduate Histology Medical Phase II, Gross Anatomy and Histology Medical Independent Study Program, Gross Anatomy Dental, Gross Anatomy, Histology and Neuroanatomy Undergraduate Anatomy, Gross Anatomy Graduate Teaching Associate: College of Dentistry, The Ohio State University, Columbus, Ohio 1978. Subject Area: Oral Histology and Embryology (Volunteer) Graduate Teaching Associate: Department of Biology, Murray State University, Murray, Kentucky. 1973-1975. Subject Areas: Anatomy and Physiology General Biology General Botany HONORS: Graduate School Leadership Award, The Ohio State University, 1979. James Scholar, University of Illinois, 1972. Phi Theta Kappa, Wabash Valley College, 1971. DEPARTMENTAL COMMITTEES: ANATOMY Graduate Committee, Student Representative, 1979-1980. Anatomy Association of Graduate Students, Representative to the Graduate Students, 1978-1979. Anatomy Association of Graduate Students, Executive Committee, 1977-1978. Student Seminar Committee, Student Representative, 1978-1979. Library Committee, Student Representative, 1977-1978. Anatomy Association of Graduate Students, Secretary/Treasurer, 1977-1978. COLLEGE OF MEDICINE COMMITTEES: Graduate Education Committee, Student Representative, 1978-1979; 1979-1980. COLLEGE OF DENTISTRY: LEADERSHIP, COMMITTEES, ORGANIZATIONS: Sophomore Class President, 1980-1981 Freshmen Class President, 1979-1980 Student Council Representative, 1979-1980; 1980-1981 Preventive Dentistry Organization, 1979-1980 Student Council Constitution Committee, 1979-1980 Research Committee, 1979-1980; 1980-1981 UNIVERSITY COMMITTEES: Council of Graduate Students, Treasurer, 1979-1980. University Graduate Council, Student Representative, 1978-1979; 1979-1980. University Research Committee, Student Representative, 1978-1979; 1979-1980. Council of Graduate Students, Delegate, 1978-1979. Executive Committee, Council of Graduate Students, 1978-1979; 1979-1980. Grievance and Procedures Committee, Student Representative, 1978-1979. Graduate-Professional Council, Representative from the Council of Graduate Students, 1978-1979. v MEMBERSHIP, ACADEMIC SOCIETIES: Student Clinician of the American Dental Association (SCADA) 1982-Present International Association of Dental Research/Amexican Association of Dental Research (IADR/AADR), 1979-Present Teratology Society, 1978-Present American Student Dental Association (ASDA) National Organization, 1979-Present American Student Dental Association (ASDA) The Ohio State University Chapter, 1979-Present Psi Omega Dental Fraternity, 1979-Present American Association for the Advancement of Science, 1977-1980 The Ohio Academy of Science, 1978-Present Beta Beta Beta, 1974-1975 PRESENTATIONS: Teratogenic effects of diphenylhydantoin (DPH) and trimethadione (TMO) in the CD-I mouse fetus. 96th Meeting of the American Association of Anatomists. April, 1983. Atlanta, Georgia. (Poster) Teratogenic effects of diphenylhydantoin (DPH) and trimethadione (TMO) in the CD-I mouse fetus. 123rd Annual Session of the American Dental Association. November, 1982. Las Vegas, Nevada. (Poster) Teratogenic effects of diphenylhydantoin and trimethadione in the CD-I mouse. The 38th Post College Assembly - The College of Dentistry of The Ohio State University. April, 1982. Columbus, Ohio. (Poster - 1st Place) Teratogenic effects of diphenylhydantoin and trimethadione in the CD-I mouse. The Columbus Dental Society. March, 1982. Columbus, Ohio. (Poster - 1st Place) An audiovisual approach to basic anatomy and physiology. The Columbus Dental Society. March, 1982. Columbus, Ohio. (Audio-visual) Teratogenic effects of diphenylhydantoin in A/J mice. The 36th Post College Assembly. The College of Dentistry
Load more

Recommended publications
  • Table II. EPCRA Section 313 Chemical List for Reporting Year 2017 (Including Toxic Chemical Categories)
    Table II. EPCRA Section 313 Chemical List For Reporting Year 2017 (including Toxic Chemical Categories) Individually listed EPCRA Section 313 chemicals with CAS numbers are arranged alphabetically starting on page II-3. Following the alphabetical list, the EPCRA Section 313 chemicals are arranged in CAS number order. Covered chemical categories follow. Note: Chemicals may be added to or deleted from the list. The Emergency Planning and Community Right-to-Know Call Center or the TRI-Listed Chemicals website will provide up-to-date information on the status of these changes. See section B.3.c of the instructions for more information on the de minimis % limits listed below. There are no de minimis levels for PBT chemicals since the de minimis exemption is not available for these chemicals (an asterisk appears where a de minimis limit would otherwise appear in Table II). However, for purposes of the supplier notification requirement only, such limits are provided in Appendix C. Chemical Qualifiers Certain EPCRA Section 313 chemicals listed in Table II have parenthetic “qualifiers.” These qualifiers indicate that these EPCRA Section 313 chemicals are subject to the section 313 reporting requirements if manufactured, processed, or otherwise used in a specific form or when a certain activity is performed. An EPCRA Section 313 chemical that is listed without a qualifier is subject to reporting in all forms in which it is manufactured, processed, and otherwise used. The following chemicals are reportable only if they are manufactured, processed, or otherwise used in the specific form(s) listed below: Chemical/ Chemical Category CAS Number Qualifier Aluminum (fume or dust) 7429-90-5 Only if it is a fume or dust form.
    [Show full text]
  • Chapter 231. Poisons and Dangerous Substances Act 1952
    Chapter 231. Poisons and Dangerous Substances Act 1952. Certified on: / /20 . INDEPENDENT STATE OF PAPUA NEW GUINEA. Chapter 231. Poisons and Dangerous Substances Act 1952. ARRANGEMENT OF SECTIONS. PART I – PRELIMINARY. 1. Interpretation. “automatic machine” “the British Pharmacopoeia” “container” “dangerous substance” “methylated spirit” “package” “poison” “poisons licence” “Poisons Register” “rectified spirit” “the regulations” “sell” “this Act” 2. Application. 3. Calculations of percentages. 4. Variation of schedules. PART II – LICENCES. 5. Poisons licence. 6. Revocation of poisons licences. PART III – SALE OF POISONS AND DANGEROUS SUBSTANCES. 7. Application of Part III to wholesalers. 8. Sale of things specified in Schedules 1 and 2. 9. Sale, etc., of things specified in Schedule 1. 10. Sale of things specified in Schedule 3. 11. Sale of things specified in Schedule 4. 12. Sale of things specified in Schedule 5. 13. Hawking poisons and dangerous substances. 14. Sale of poisons to persons under 18 years, etc. 15. Automatic vending machines. 16. Poisons Registers. 17. Entries in Poisons Registers. 18. Person unable to sign his name. 19. Sale on order by letter, etc. 20. Sale to medical practitioners, etc. 21. Application of Sections 14, 17, 18 and 19. 22. Records to be kept by medical practitioners, etc. PART IV – LABELLING AND PACKING POISONS AND DANGEROUS SUBSTANCES. 23. Sale of poisons and dangerous substances. 24. Sale of liquid dangerous substances. 25. Colouring of methylated spirits. 26. Sale of poisons. PART V – MISCELLANEOUS. 27. Drinking of methylated spirit prohibited. 28. Methylated spirit not to be sold for drinking purposes. 29. Inspection. 30. Offences in relation to the sale of poisons, etc.
    [Show full text]
  • Dissociation Constants of Organic Acids and Bases
    DISSOCIATION CONSTANTS OF ORGANIC ACIDS AND BASES This table lists the dissociation (ionization) constants of over pKa + pKb = pKwater = 14.00 (at 25°C) 1070 organic acids, bases, and amphoteric compounds. All data apply to dilute aqueous solutions and are presented as values of Compounds are listed by molecular formula in Hill order. pKa, which is defined as the negative of the logarithm of the equi- librium constant K for the reaction a References HA H+ + A- 1. Perrin, D. D., Dissociation Constants of Organic Bases in Aqueous i.e., Solution, Butterworths, London, 1965; Supplement, 1972. 2. Serjeant, E. P., and Dempsey, B., Ionization Constants of Organic Acids + - Ka = [H ][A ]/[HA] in Aqueous Solution, Pergamon, Oxford, 1979. 3. Albert, A., “Ionization Constants of Heterocyclic Substances”, in where [H+], etc. represent the concentrations of the respective Katritzky, A. R., Ed., Physical Methods in Heterocyclic Chemistry, - species in mol/L. It follows that pKa = pH + log[HA] – log[A ], so Academic Press, New York, 1963. 4. Sober, H.A., Ed., CRC Handbook of Biochemistry, CRC Press, Boca that a solution with 50% dissociation has pH equal to the pKa of the acid. Raton, FL, 1968. 5. Perrin, D. D., Dempsey, B., and Serjeant, E. P., pK Prediction for Data for bases are presented as pK values for the conjugate acid, a a Organic Acids and Bases, Chapman and Hall, London, 1981. i.e., for the reaction 6. Albert, A., and Serjeant, E. P., The Determination of Ionization + + Constants, Third Edition, Chapman and Hall, London, 1984. BH H + B 7. Budavari, S., Ed., The Merck Index, Twelth Edition, Merck & Co., Whitehouse Station, NJ, 1996.
    [Show full text]
  • Spiro-Tricyclicaromatic Succinimide Derivatives As Inhibitors of Aldose Reductase
    Eurouropaisches Patentamt 9) J EuroEuropean Patent Office © Publication number: 0 137 333 Offic)ffice europeen des brevets A2 © EUROPEAN PATENT APPLICATION Si) Application number: 84110855.8 © Int. CI.4: C 07 D 209/96 C 07 D 235/02, C 07 D 263/52 © Date of filing: 12.09.84 C 07 D 277/60, C 07 D 471/10 C 07 D 491/107, C 07 D 495/10 C 07 D 487/10, C 07 D 513/10 C 07 D 498/10, C 07 D 471/20 30) Priority: 14.09.83 US 532168 ©Applicant: ALCON LABORATORIES INC 6201 South Freeway P.O. Box 1959 Fort Worth Texas 761 01 (US) «) Date of publication of application: 17.04.85 Bulletin 85/16 @ Inventor: York, Billie M. Jr. 3828 Winifred Drive w) Designated Contracting States: Fort Worth Texas 76133IUS) AT BE CH DE FR GB IT LI LU NL SE @ Representative: Patentanwalte Kohler - Schwindling - Spath Hohentwielstrasse 41 D-7000 Stuttgart 1{DE) (54) Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase. Disclosed are substituted or unsubstituted planar tricy- clic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These com- pounds are useful, inter alia, in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising adminis- tering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome. Field of the Invention This invention relates to novel spiro-tricyclicaromatic succinimide derivatives and related spiro-heterocyclic analogs such as spiro- tricyclicaromatic-thiazolidine-dione, -imidazolidinedione, and -oxazolidine- dione derivatives.
    [Show full text]
  • NJ Environmental Hazardous Substance List by CAS Number
    NJ Community Right to Know Environmental Hazardous Substance (EHS) List in CAS Number Order Reporting Quantity (RQ) Sub. DOT if below CAS Number Substance Name No. No. 500 pounds Haz Waste, N.O.S. (only if EHS reported) liquid 2461 3082 Haz Waste, N.O.S. (only if EHS reported) solid 2461 3077 Organorhodium Complex (PMN-82-147) * + 2611 2811 10 Petroleum Oil4 2651 1270 Substance Samples (only if EHS reported) 3628 Waste Oil4 2851 1270 50-00-0 Formaldehyde * 0946 1198 50-07-7 Mitomycin C * 1307 1851 50-14-6 Ergocalciferol * 2391 1851 50-29-3 DDT 0596 2761 51-03-6 Piperonyl butoxide 3732 51-21-8 Fluorouracil * 1966 1851 51-28-5 2,4-Dinitrophenol 2950 0076 51-75-2 Mechlorethamine * + (S) 1377 2810 10 51-75-2 Nitrogen mustard * + (S) 1377 2810 10 51-79-6 Urethane 1986 51-83-2 Carbachol chloride * 2209 52-68-6 Trichlorfon 1882 2783 52-85-7 Famphur 2915 2588 53-96-3 2-Acetylaminofluorene 0010 54-11-5 Nicotine * + 1349 1654 100 54-62-6 Aminopterin * 2112 2588 55-18-5 N-Nitrosodiethylamine 1404 55-21-0 Benzamide 2895 55-38-9 Fenthion 0916 2902 (O,O-Dimethyl O-[3-methyl-4-(methylthio) phenyl] ester, phosphorothioic acid) 55-63-0 Nitroglycerin 1383 0143 55-91-4 Isofluorphate * + 2500 3018 100 56-23-5 Carbon tetrachloride 0347 1846 56-25-7 Cantharidin * + 2207 100 56-35-9 Bis(tributyltin) oxide 3479 2902 56-38-2 Parathion * + 1459 2783 100 56-72-4 Coumaphos * + 0536 2783 100 57-12-5 Cyanide 0553 1588 57-14-7 1,1-Dimethyl hydrazine * 0761 2382 57-24-9 Strychnine * + 1747 1692 100 57-33-0 Pentobarbital sodium 3726 57-41-0 Phenytoin 1507 57-47-6 Physostigmine * + 2681 2757 100 57-57-8 beta-Propiolactone * 0228 57-64-7 Physostigmine, salicylate (1:1) * + 2682 2757 100 57-74-9 Chlordane * 0361 2762 58-36-6 Phenoxarsine, 10,10'-oxydi- * 2653 1557 58-89-9 Lindane * 1117 2761 59-88-1 Phenylhydrazine hydrochloride * 2659 2572 59-89-2 N-Nitrosomorpholine 1409 60-09-3 4-Aminoazobenzene 0508 1602 60-11-7 4-Dimethylaminoazobenzene (S) 0739 1602 60-11-7 C.I.
    [Show full text]
  • A Brief Overview of Epilepsy
    Global Journal of Medical Research: A Neurology and Nervous System Volume 16 Issue 1 Version 1.0 Year 2016 Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Inc. (USA) Online ISSN: 2249-4618 & Print ISSN: 0975-5888 A Brief Overview of Epilepsy By Vikash Kumar Chaudhari, Pushpendra Kumar, Vijay Yadav, Devender Pathak & Zeashan Hussain Abstract- Epilepsy is a group of neurological diseases characterized by epileptic seizures. Epileptic seizures are episodes that can vary from brief and nearly undetectable to long periods of vigorous shaking. In epilepsy, seizures tend to recur, and have no immediate underlying cause while seizures that occur due to a specific cause are not deemed to represent epilepsy. The cause of most cases of epilepsy is unknown, although some people develop epilepsy as the result of brain injury, stroke, brain tumors, and substance use disorders. Keywords: epilepsy, neurological disease, seizures. GJMR-A Classification : NLMC Code: WL 385 ABriefOverviewofEpilepsy Strictly as per the compliance and regulations of: © 2016. Vikash Kumar Chaudhari, Pushpendra Kumar, Vijay Yadav, Devender Pathak & Zeashan Hussain. This is a research/ review paper, distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A Brief Overview of Epilepsy Vikash Kumar Chaudhari α, Pushpendra Kumar σ, Vijay Yadav ρ, Devender Pathak Ѡ & Zeashan Hussain ¥ Abstract- Epilepsy is a group of neurological diseases Anticonvulsants act to prevent the spread of the characterized by epileptic seizures.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2008/0108602 A1 Nagy Et Al
    US 2008O1086O2A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2008/0108602 A1 Nagy et al. (43) Pub. Date: May 8, 2008 (54) PREVENTION OF OBESITY IN (21) Appl. No.: 11/687,954 ANTIPSYCHOTIC, ANTIDEPRESSANT AND ANTIEPLEPTIC MEDCATION (22) Filed: Mar. 19, 2007 (75) Inventors: Peter Literati Nagy, Budapest Related U.S. Application Data (HU); Jesse Roth, Whitestone, NY (US); Zoltan Szilvassy, (60) Provisional application No. 60/856,177, filed on Nov. Debrecen-Jozsa (HU); Kalman 2, 2006. Tory, Budapest (HU); Mike Brownstein, Rockville, MD (US); Publication Classification Kalman Takacs, Budapest (HU); Laszlo Vigh, Szeged (HU); Jozsef (51) Int. Cl. Mandi, Budapest (HU); Balazs A6II 3/445 (2006.01) Sumegi. Pecs (HU); Sandor A 6LX 3/59 (2006.01) Bernath, Telki (HU); Attila A6II 3/55 (2006.01) Kolonics, Budapest (HU); Gabor A6IP3/04 (2006.01) Balogh, Szeged (HU); Janos Egri. Budapest (HU) (52) U.S. Cl. .................... 514/220; 514/259.41: 514/318 Correspondence Address: (57) ABSTRACT FSH & RICHARDSON PC P.O. BOX 1022 O-(3-piperidino-2-hydroxypropyl)-nicotinic amidoxime or a MINNEAPOLIS, MN 55440-1022 pharmaceutically suitable acid addition salt thereof (BGP 15) can be used for the prevention or reduction of weight (73) Assignee: N-Gene Research Laboratories, gain or obesity in a patient treated with an antipsychotic drug Inc. or an antidepressant drug or an antiepileptic drug. US 2008/0108602 A1 May 8, 2008 PREVENTION OF OBESITY IN amidoximic acid derivative including BGP-15. A preferred ANTIPSYCHOTIC, ANTIDEPRESSANT AND myopathy is cardiomyopathy. Neurodegenerative diseases ANTIEPLEPTIC MEDCATION include Parkinson's disease, Huntington's disease and amyotrophic lateral Sclerosis.
    [Show full text]
  • Succinimide Derivatives As Ocular Hypotensive Agents Succinimid-Derivate Als Okulare Hypotensive Mittel Derives De Succinimide En Tant Qu’Agents Hypotensifs Oculaires
    (19) TZZ__ _T (11) EP 1 951 229 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: (2006.01) (2006.01) of the grant of the patent: A61K 31/4015 A61P 27/06 10.07.2013 Bulletin 2013/28 (86) International application number: PCT/IL2006/001315 (21) Application number: 06809871.4 (87) International publication number: (22) Date of filing: 14.11.2006 WO 2007/057889 (24.05.2007 Gazette 2007/21) (54) SUCCINIMIDE DERIVATIVES AS OCULAR HYPOTENSIVE AGENTS SUCCINIMID-DERIVATE ALS OKULARE HYPOTENSIVE MITTEL DERIVES DE SUCCINIMIDE EN TANT QU’AGENTS HYPOTENSIFS OCULAIRES (84) Designated Contracting States: (72) Inventor: Sharir, Mordechai AT BE BG CH CY CZ DE DK EE ES FI FR GB GR 75463 Rishon Lezion (IL) HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser (30) Priority: 21.11.2005 IL 17207005 Leopoldstrasse 4 28.11.2005 US 739964 P 80802 München (DE) (43) Date of publication of application: (56) References cited: 06.08.2008 Bulletin 2008/32 US-A- 4 188 398 US-A- 4 609 663 US-A- 4 981 867 US-A1- 2005 175 690 (73) Proprietor: Sharir, Mordechai 75463 Rishon Lezion (IL) Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid.
    [Show full text]
  • Drug/Substance Trade Name(S)
    A B C D E F G H I J K 1 Drug/Substance Trade Name(s) Drug Class Existing Penalty Class Special Notation T1:Doping/Endangerment Level T2: Mismanagement Level Comments Methylenedioxypyrovalerone is a stimulant of the cathinone class which acts as a 3,4-methylenedioxypyprovaleroneMDPV, “bath salts” norepinephrine-dopamine reuptake inhibitor. It was first developed in the 1960s by a team at 1 A Yes A A 2 Boehringer Ingelheim. No 3 Alfentanil Alfenta Narcotic used to control pain and keep patients asleep during surgery. 1 A Yes A No A Aminoxafen, Aminorex is a weight loss stimulant drug. It was withdrawn from the market after it was found Aminorex Aminoxaphen, Apiquel, to cause pulmonary hypertension. 1 A Yes A A 4 McN-742, Menocil No Amphetamine is a potent central nervous system stimulant that is used in the treatment of Amphetamine Speed, Upper 1 A Yes A A 5 attention deficit hyperactivity disorder, narcolepsy, and obesity. No Anileridine is a synthetic analgesic drug and is a member of the piperidine class of analgesic Anileridine Leritine 1 A Yes A A 6 agents developed by Merck & Co. in the 1950s. No Dopamine promoter used to treat loss of muscle movement control caused by Parkinson's Apomorphine Apokyn, Ixense 1 A Yes A A 7 disease. No Recreational drug with euphoriant and stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. It is often claimed that BZP was originally Benzylpiperazine BZP 1 A Yes A A synthesized as a potential antihelminthic (anti-parasitic) agent for use in farm animals.
    [Show full text]
  • New York City Department of Environmental Protection Community Right-To-Know: List of Hazardous Substances
    New York City Department of Environmental Protection Community Right-to-Know: List of Hazardous Substances Updated: 12/2015 Definitions SARA = The federal Superfund Amendments and Reauthorization Act (enacted in 1986). Title III of SARA, known as the Emergency Planning and Community Right-to-Act, sets requirements for hazardous chemicals, improves the public’s access to information on chemical hazards in their community, and establishes reporting responsibilities for facilities that store, use, and/or release hazardous chemicals. RQ = Reportable Quantity. An amount entered in this column indicates the substance may be reportable under §304 of SARA Title III. Amount is in pounds, a "K" represents 1,000 pounds. An asterisk following the Reporting Quantity (i.e. 5000*) will indicate that reporting of releases is not required if the diameter of the pieces of the solid metal released is equal to or exceeds 100 micrometers (0.004 inches). TPQ = Threshold Planning Quantity. An amount entered in this column reads in pounds and indicates the substance is an Extremely Hazardous Substance (EHS), and may require reporting under sections 302, 304 & 312 of SARA Title III. A TPQ with a slash (/) indicates a "split" TPQ. The number to the left of the slash is the substance's TPQ only if the substance is present in the form of a fine powder (particle size less than 100 microns), molten or in solution, or reacts with water (NFPA rating = 2, 3 or 4). The TPQ is 10,000 lb if the substance is present in other forms. A star (*) in the 313 column= The substance is reportable under §313 of SARA Title III.
    [Show full text]
  • FIGURE 1 Human Subjects with Bispecific Anti-CD 123 X Anti-CD3 Antibodies
    ( (51) International Patent Classification: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, A61K 39/395 (2006.01) A61P 35/02 (2006.01) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. A61P 35/00 (2006.01) C07K 16/28 (2006.01) (84) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of regional protection available) . ARIPO (BW, GH, PCT/US20 19/035203 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (22) International Filing Date: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 03 June 2019 (03.06.2019) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (25) Filing Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, Cl, CM, GA, GN, GQ, GW, (26) Publication Language: English KM, ML, MR, NE, SN, TD, TG). (30) Priority Data: 62/679,25 1 0 1 June 2018 (01.06.2018) US Published: 62/713,439 0 1 August 2018 (01.08.2018) US — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the (71) Applicant: XENCOR, INC. [US/US]; 111 West Lemon claims and to be republished in the event of receipt of Avenue, Monrovia, CA 91016 (US). amendments (Rule 48.2(h)) (72) Inventors: SAVILLE, Michael, Wayne; d o Xencor, Inc., — with sequence listing part of description (Rule 5.2(a)) I l l West Lemon Avenue, Monrovia, CA 91016 (US).
    [Show full text]
  • Differential Effects of Petit Mal Anticonvulsants and Convulsants on Thalamic Neurones: GABA Current Blockade 'Douglas A
    Br. J. Pharmacol. (1990), 100, 807-813 %I--" Macmillan Press Ltd, 1990 Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade 'Douglas A. Coulter, John R. Huguenard & David A. Prince Department of Neurology and Neurological Sciences, Rm M016, Stanford University Medical Center, Stanford, CA 94305, U.S.A. 1 Currents evoked by applications of y-aminobutyric acid (GABA) to acutely dissociated thalamic neu- rones were analysed by voltage-clamp techniques, and the effects of the anticonvulsant succinimides etho- suximide (ES) and a-methyl-a-phenylsuccinimide (MPS) and the convulsants tetramethylsuccinimide (TMS), picrotoxin, pentylenetetrazol (PTZ), and bicuculline methiodide were assessed. 2 TMS (1 juM-10mM) reduced responses to iontophoretically applied GABA, as did picrotoxin (0.1- 100uM), PTZ (1-100mM) and bicuculline (1-100pM). 3 ES, in high concentrations (1-10mM), reduced GABA responses to a lesser extent, and also occluded the reductions in GABA-evoked currents produced by TMS, picrotoxin, and PTZ. ES did not occlude the effects of bicuculline on GABA responses. Therefore, we propose that ES acts as a partial agonist at the picrotoxin GABA-blocking receptor. 4 MPS had no effect on GABA responses (at a concentration of mM), and, like ES, occluded the GABA-blocking actions of TMS, apparently acting as a full antagonist. 5 The anticonvulsant actions of ES and MPS against TMS and PTZ-induced seizures may thus involve two independent mechanisms: (1) the occlusion of TMS and PTZ GABA-blocking effects; and (2) the previously described specific effect of ES and MPS on low-threshold calcium current of thalamic neu- rones.
    [Show full text]