CHAIR SUMMIT Master Class for Neuroscience Professional Development
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#CHAIR2014 7TH ANNUAL CHAIR SUMMIT Master Class for Neuroscience Professional Development September 11 – 13, 2014 | Westin Tampa Harbour Island Sponsored by #CHAIR2014 Obesity And Food Addiction: A Global Concern Mark S. Gold, MD 17th University of Florida Distinguished Alumni Professor and Chairman University of Florida, Retired Gainesville, FL Mark S. Gold, MD Disclosures ● Chairman, Scientific Advisory Boards for Addiction & Psychiatry, Eating Disorders, Overeating, & Obesity for RiverMend Health and Wellspring Obesity Camps for Teens Mark S. Gold, MD Patent Disclosures Granted Patents & Sold ● Clonidine as an Opiate-Like Drug & Method of eliminating opiate withdrawal symptoms with clonidine in humans. #4,312,878 January 26, 1982 (See Gold, Redmond, Kleber, Lancet 1(8070)929-930, 1978. Patent Gold, Redmond, Kleber, +Aghajanian)—sold to Boerhinger ● Dopamine Depletion Hypothesis of Cocaine and Amphetamine Addiction & Brompocriptine –Dopamine Augmentation method of eliminating cocaine withdrawal. #731,102 and #791,188 ; #20, 1941.2,1986 US 7,611,858 BI April 20, 2007(Gold and Dackis Clin Ther 7(1):6-21, 1984 Dackis and Gold, Lancet 1(8438)1151-1152, 1985- –Sold to Novartis Mark S. Gold, MD Patent Disclosures Granted Patents & Licensed ● Detection of Cannabinoid Receptor Biomarkers and Uses Thereof Patent # US 7,611,858 BI April 20, 2007 ● Method and Apparatus for Detecting Environmental Smoke Exposure #7/052,468, May 30, 2006. ● Marker Detection Method and Apparatus to Monitor Drug Compliance #60/164,250, Filed November 8, 2000 ● Method and Apparatus for Detecting Illicit Substances #60/292,964 filed May 23, 2001 ● Methods and Apparatus for Therapeutic Drug Monitoring using Exhaled Breath #10/788,501 filed February 26, 2004 ● Novel Methods and Apparatus for Therapeutic Drug Monitoring Using Exhaled Breath # 10/788, 501, Filed February 26, 2004. ● Methods and Systems for Preventing Diversion of Prescription Drugs- #11/578,332, Filed September 20, 2004. ● System and Method for Monitoring Health Using Exhaled Breath - #11/301, 911, Filed December 13, 2005. ● System and Method for Monitoring Health Using Exhaled Breath (Propofol Claims) #11/512, 856, Filed August 29, 2006. ● A Novel System for Monitoring Environmental Contamination from Controlled Substances UF11458 ● Diagnosis and Treatment of Neurological Inflammation WO 2008/008819 ● System and method for monitoring health using exhaled breath # 20070167,853, Filed July 19, 2007. ● Devices and Methods for the Collection and Detection of Substances on Surfaces and Air # 60/971,451. Filed September 11, 2007. Mark S. Gold, MD Patent Disclosures Granted Patents & Licensed ● System and Method for Real-Time Diagnosis, Treatment, and Therapeutic Drug Monitoring # 20070258894 filed November 7, 2007. ● Medication Adherence Monitoring System # 12/064, 673 filed February 25, 2008 ● Methods and Systems for Preventing Diversion of Prescription Drugs #20080059226 filed March 6, 2008. ● Varenicline, Appetite, and Weight Reduction UF#12961 Filed August 6, 2008 ● Nicotine Agonist in Varenicline in the Treatment of Attention Disorders UF#12964 Filed August 7, 2008 ● Devices and Methods for the Collection and Detection of Substances (Gold et al.) Serial No. 12/208,896; filed September 11, 2008. ● Closed Loop Medication Delivery System Employing Photoplethysmography to Improve Safety UF# 13420 Filed December 10, 2009 ● Baclofen/Naltrexone Combination Therapy for Suppressing Binge Eating of Palatable Food UF#-13854 Filed November 2011 ● Rat Screening Protocol to Predict Novel Treatments for Obesity, UF#14007 April 2012 Mark S. Gold, MD Patent Disclosures Granted Patents & Licensed ● Canadian Patent No. 2,678,969. Medication Adherence Monitoring System - TH Reference: 292401-2231; UF Ref.: 12393; XHALE Ref.: 10457-132CA Nov. 13, 2012 ● Intelligent Drug and/or Fluid Delivery System to Optimizing Medical Treatment of Therapy Using Pharmacodynamic and/or Pharmacokinetic Data UF#13535. January 30, 2013. ● Central Site Photoplethysmography, Medication Administration, And Safety, UF#13843, Xhale Ref: XH-191PCT, Filed February 15, 2013, REF. 290106-103. ● Devices and methods for the Collection and Detection of Substances (CIP). UF#13294 Issued Patent No: 8,388,907 (Gold et.at.) Issued: March 5, 2013. ● Devices and Methods for the Collection and Detection of Substances (Gold et al.) UF#-12604 Serial No. 12/208,896; filed September 11, 2008-US Patent No. 8,414,846 April 9, 2013. ● Devices and Methods for the Collection and Detection of Substances (Gold et al.) UF#14626 Ref# UF.600XC2D1, Serial No. 12/763,924; Filed February 2013. 7 #CHAIR2014 Learning Objective 1 Implement counseling or address weight management strategies for overweight or obese patients. #CHAIR2014 Learning Objective 2 Apply the most up-to-date treatment guidelines, safety and efficacy data, and evidence-based criteria for currently available and emerging therapies for the management of overweight and obese patients, which include diet and lifestyle modifications, pharmacotherapies, and surgery. Weight Obsessed USA ● Most of us are thinking about our weight ● Many are on a diet ● Much of the media is obsessed with the nearly anorexic and those who have had short term weight loss, relapsed, and become obese ● Loss of control over eating, eating more than intended, eating to full or over-full, too many food “lets eat” signals and too little counter-balancing controls Wall Street Journal: Food May be Addicting for Some A new study suggests that people who struggle to say no to chocolate, french fries or other junk food suffer from something more insidious than lack of willpower, they may actually have an addiction. Heller K. http://online.wsj.com/article/ SB10001424052748703712504576243192495912186.html? mod=WSJ_hp_MIDDLENexttoWhatsNewsThird. April 5, 2014. How Did I Start Thinking About Obesity as an Addiction? ● I like french fries ● Woodstock ● Tobacco cases ● Drug addiction treatment ! HALT ! Drug craving…eat…chocolate/cake/cookies Our Clinical Research Group Sees Food and Drugs are Related to Each Other & Addictions ● Gold MS, Sternbach HA. Endorphins in obesity and in the regulation of appetite and weight. Integrative Psychiatry. 1984;2(6):203-210. ● Jonas JM, Gold MS. Cocaine abuse and eating disorders. Lancet. 1986;1(8477):390-391. ● Jonas JM, Gold MS, et al. Eating disorders and cocaine abuse: a survey of 259 cocaine abusers. J Clin Psychiatry. 1987;48(2):47-50. ● Gold MS. Etiology and management of obesity. Dir In Psychiatry. 1999;19(20):419-439. ● Gold MS, Frost-Pineda K, Jacobs WS. Overeating, binge eating, and eating disorders as addictions. Psychiatric Annals. 2003;33(2):117-122. ● Gold MS. Eating disorders, overeating, and pathological attachment to food: independent or addictive disorders? Binghamton, NY; Haworth Press. ● Warren MW, Gold MS. The relationship between obesity and drug use. Am J Psychiatry. 2007;164(8):1268. Yale Hosts Historic Conference on Food and Addiction ● New Haven, Conn. — In what is believed to be the first meeting of its kind, Yale University convened nearly 40 experts on nutrition, obesity, and addiction to discuss the controversial topic of food and addiction. ● Nora Volkow, MD, director of the National Institute on Drug Abuse, the keynote speaker, “It is important that we study the reasons that people behave in unhealthy ways even when they are aware of potentially devastating consequences,” Volkow said. “We believe we can learn a lot about obesity by looking at what we know about the science of drug addiction. In this meeting we will be discussing the commonalities in the brain’s reward mechanisms related to compulsive eating as well as drug use for non-medical reasons.” ● Among the topics of discussion: MRI research and other work that shows strong similarities in ways drugs and certain foods affect the brain; the relationship between eating and reward systems in the brain; psychological similarities between food cravings and cravings for drugs, and the implications of this work for government policy, clinical intervention, and the law. Yale Office of Public Affairs & Communications. Yale Hosts Historic Conference on Food and Addiction. http:// opac.yale.edu/news/article.aspx?id=1581#. July 9, 2007. Accessed Sept. 20, 2011. Yale Hosts Historic Conference on Food and Addiction ● Although terms such as “chocoholic” and “carbohydrate addict” are prevalent in popular culture, there is little scientific consensus about food as an addiction, said Yale Psychology Professor Kelly Brownell, co-chair of the meeting. ● “Everything changes if food is found to have addictive properties, especially the legal and legislative landscape around marketing foods to children,” said Brownell, director of the Rudd Center for Food Policy and Obesity at Yale. “People often use the language of addiction to explain their relationship with food cravings, withdrawal, irresistible impulses—it is all there.” ● Co-chair Mark Gold of the University of Florida, said that in the past, addiction was defined by tolerance and withdrawal. “After our work and that of others on cocaine, it was clear that addiction was more like a pathological, often fatal attraction,” Gold said. “The definition of addiction was changed and gambling and sex addiction were considered addictions. Overeating and obesity are candidates for Addictive Disease and such a hypothesis is both testable in humans and can produce novel approaches and treatments for a major public health problem.” ● Gold said that food, especially highly palatable food, can produce