CHRNA2 Antibody Cat. No.: 56-130

CHRNA2 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This CHRNA2 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 42-69 amino acids from the N-terminal region of human CHRNA2.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 60 kDa WEIGHT:

Properties

This antibody is purified through a A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

September 24, 2021 1 https://www.prosci-inc.com/chrna2-antibody-56-130.html PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: CHRNA2

ALTERNATE NAMES: Neuronal subunit alpha-2, CHRNA2

ACCESSION NO.: Q15822

PROTEIN GI NO.: 308153405

GENE ID: 1135

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR BACKGROUND: subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with dependence.

REFERENCES: 1) Saccone, N.L., et al. Brain Behav. 9(7):741-750(2010)

2) Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)

3) Rigbi, A., et al. Pharmacogenomics J. (2010) In press :

4) Hoda, J.C., et al. FEBS Lett. 583(10):1599-1604(2009)

ANTIBODIES FOR RESEARCH USE ONLY.

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