CHRNA2 Antibody Cat. No.: 56-130
CHRNA2 Antibody
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Human
This CHRNA2 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 42-69 amino acids from the N-terminal region of human CHRNA2.
TESTED APPLICATIONS: WB
APPLICATIONS: For WB starting dilution is: 1:1000
PREDICTED MOLECULAR 60 kDa WEIGHT:
Properties
This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.
CLONALITY: Polyclonal
ISOTYPE: Rabbit Ig
CONJUGATE: Unconjugated
September 24, 2021 1 https://www.prosci-inc.com/chrna2-antibody-56-130.html PHYSICAL STATE: Liquid
BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION: batch dependent
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
OFFICIAL SYMBOL: CHRNA2
ALTERNATE NAMES: Neuronal acetylcholine receptor subunit alpha-2, CHRNA2
ACCESSION NO.: Q15822
PROTEIN GI NO.: 308153405
GENE ID: 1135
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR BACKGROUND: subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.
REFERENCES: 1) Saccone, N.L., et al. Genes Brain Behav. 9(7):741-750(2010)
2) Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
3) Rigbi, A., et al. Pharmacogenomics J. (2010) In press :
4) Hoda, J.C., et al. FEBS Lett. 583(10):1599-1604(2009)
ANTIBODIES FOR RESEARCH USE ONLY.
For additional information, visit ProSci's Terms & Conditions Page.
September 24, 2021 2 https://www.prosci-inc.com/chrna2-antibody-56-130.html