CHRNA2 Antibody Cat

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CHRNA2 Antibody Cat. No.: 56-130 CHRNA2 Antibody Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Human This CHRNA2 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 42-69 amino acids from the N-terminal region of human CHRNA2. TESTED APPLICATIONS: WB APPLICATIONS: For WB starting dilution is: 1:1000 PREDICTED MOLECULAR 60 kDa WEIGHT: Properties This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification. CLONALITY: Polyclonal ISOTYPE: Rabbit Ig CONJUGATE: Unconjugated September 24, 2021 1 https://www.prosci-inc.com/chrna2-antibody-56-130.html PHYSICAL STATE: Liquid BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide. CONCENTRATION: batch dependent Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. Additional Info OFFICIAL SYMBOL: CHRNA2 ALTERNATE NAMES: Neuronal acetylcholine receptor subunit alpha-2, CHRNA2 ACCESSION NO.: Q15822 PROTEIN GI NO.: 308153405 GENE ID: 1135 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR BACKGROUND: subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. REFERENCES: 1) Saccone, N.L., et al. Genes Brain Behav. 9(7):741-750(2010) 2) Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010) 3) Rigbi, A., et al. Pharmacogenomics J. (2010) In press : 4) Hoda, J.C., et al. FEBS Lett. 583(10):1599-1604(2009) ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 24, 2021 2 https://www.prosci-inc.com/chrna2-antibody-56-130.html.

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