Influenza and Covid-19 severity 1 Report Correlation of Influenza Vaccination and Influenza Incidence on Covid-19 Severity Mark Christopher Arokiaraj, MD DM, Cardiology, Pondicherry Institute of Medical Sciences, India 605014.
[email protected] Key words: Covid-19, Influenza vaccination, Influenza lower respiratory tract infections, Mortality, Morbidity, Immunity. Abstract The pandemic of Covid-19 is evolving worldwide, and it is associated with high mortality and morbidity. There is a growing need to discuss the elements of coordinated strategy to control the spread and mitigate the severity and mortality of Covid-19. H1N1 vaccine and streptococcus pneumonia vaccines are available. The current analysis was performed to correlate the severity of Covid-19 and influenza (H1N1) vaccination statistics and also the influenza lower respiratory tract incidence. There is a correlation between Covid-19 related mortality and morbidity and the status of influenza vaccination, which appears protective. The tendency of correlation is more visualized as the pandemic is evolving. The case incidence and recovery parameters also showed a beneficial trend. Since evolutionarily influenza is close to SARS-CoV-2 viruses and shares some common epitopes and mechanisms, there is a possibility of partial protection to reduce the Covid-19 related severity using the influenza vaccination. In countries where influenza immunization is less, there is a correlation between lower respiratory tract infections (LRI) and influenza attributable to lower respiratory tract infections incidence and Covid-19 severity, which is beneficial. Receiver operating curve (ROC) statistics showed an area under the curve of 0.86 (CI 0.78 to 0.944, P <0.0001) to predict Covid-19 mortality >150/million, and a decreasing trend of influenza LRI episodes.