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Link 20-Apr-2021 JAMA Immunogenicity of the Ad26.COV2 07/052021 Date Journal Title Study type Country Authors Link Trial identifier Intervention Main question To evaluate the immunogenicity of the Ad26.COV2.S vaccine Ad26.COV2.S vaccine (Janssen/Johnson & Johnson) in Immunogenicity of the Ad26.COV2.S Vaccine for Stephenson KE et https://pubmed.ncbi.nl (by Janssen 20‐Apr‐2021 JAMA RCT USA NCT04436276 humans, including the kinetics, COVID‐19 al m.nih.gov/33704352/ Pharmaceutical magnitude, and phenotype of SARS‐ Companies) CoV‐2 spike‐specific humoral and cellular immune responses Combination of To compare the rate and time of Effect of a combination of nitazoxanide, https://www.ncbi.nlm.ni nitazoxanide, viral clearance in subjects receiving J of Medical ribavirin, and ivermectin plus zinc supplement h.gov/pmc/articles/PMC ribavirin, and the combination of nitazoxanide, 11‐Mar‐2021 CT Egypt Elalfy H et al NCT04392427 Virology (MANS.NRIZ study) on the clearance of mild 8014583/pdf/JMV‐9999‐ ivermectin plus Zinc ribavirin, and ivermectin plus zinc COVID‐19 0.pdf vs supportive versus those receiving supportive treatment treatment. XAV‐19 0.5 mg/kg at Pharmacokinetics and safety of XAV‐19, a day 1 and day 5 To assess the pharmacokinetics and https://www.medrxiv.or swine glyco‐humanized polyclonal anti‐ SARS‐ (group 1), 2 mg/kg at safety of XAV‐19, a swine glyco‐ g/content/10.1101/2021 20‐Apr‐2021 MedRxiv CoV‐2 antibody, for COVID‐19‐related RCT France Gaborit B et al NCT04453384 day 1 and day 5 humanized polyclonal antibody .04.15.21255549v1.full.p (group 2), 2 mg/kg at against SARS‐CoV‐2, in COVID‐19‐ moderate pneumonia: a randomized, double‐ df blind, placebo‐controlled, phase IIa study day 1 (group 3) or related moderate pneumonia placebo https://www.nejm.org/ To assest the Safety and Efficacy of Safety and Efficacy of Single‐Dose Ad26.COV2.S Vaccine RCT III 21‐Apr‐21 NEJM International Sadoff J et al. doi/10.1056/NEJMoa210 NCT04505722 Ad26.COV2.S vaccine Single‐Dose Ad26.COV2.S Vaccine Vaccine against Covid‐19 phase 1544 against Covid‐19 https://ashpublications. org/blood/article/doi/10 Efficacy of the BNT162b2 mRNA COVID‐19 Vaccine .1182/blood.202101156 BNT162b2 mRNA To determine the efficacy of COVID‐ 16‐Apr‐21 Blood Vaccine trial Israel Herishanu Y, et al. NCT04746092 in Patients with Chronic Lymphocytic Leukemia 8/475742/Efficacy‐of‐ COVID19 vaccine 19 vaccine in patients with CLL. the‐BNT162b2‐mRNA‐ COVID‐19‐Vaccine‐in https://journals.lww.co Immunogenicity and safety of a SARS‐CoV‐2 ChiCTR2000038 To assess the immunogenicity and Chinese m/cmj/Abstract/9000/I inactivated vaccine in healthy adults randomized, vaccine RCT I/II 804, KCONVAC ‐ SARS‐CoV‐ safety of an inactivated SARS‐CoV‐2 28‐Apr‐21 Medical China Pan HX, et al. mmunogenicity_and_saf double‐blind, and placebo‐controlled phase 1 and phase ChiCTR2000039 2 inactivated vaccine vaccine, KCONVAC, in healthy Journal ety_of_a_SARS_CoV_2.9 phase 2 clinical trials 462 adults. 8627.aspx To determine whether Effect of Early Treatment With Hydroxychloroquine https://jamanetwork.co hydroxychloroquine or lopinavir‐ JAMA Netw or Lopinavir and Ritonavir on Risk of Hospitalization m/journals/jamanetwor hydroxychloroquine ritonavir reduces hospitalization 22‐Apr‐21 RCT International Reis G et al. NCT04403100 Open. Among Patients With COVID‐19 kopen/fullarticle/277904 or lopinavir‐ritonavir among high‐risk patients with early The TOGETHER Randomized Clinical Trial 4 symptomatic COVID‐19 in an outpatient setting. https://search.bvsalud.o to evaluate rg/global‐literature‐on‐ whether pyridostigmine could Pyridostigmine in adults with severe SARS‐CoV‐2 Fragoso‐Saavedra S, decrease invasive mechanical 5‐May‐21 MedRxiv RCT Mexico novel‐coronavirus‐2019‐ NCT04343963 pyridostigmine infection: the PISCO trial et al. ventilation (IMV) ncov/resource/en/ppme and death in patients with severe drxiv‐21255834 COVID-19 Impact and effectiveness of mRNA BNT162b2 https://www.thelancet.c vaccine against SARS‐CoV‐2 infections and COVID‐19 om/journals/lancet/artic Real‐world effectiveness of two 5‐May‐21 The Lancet cases, hospitalisations, and deaths following a Observational study Israel Haas et al. le/PIIS0140‐ NA BNT162b2 doses of BNT162b2 against SARS‐ nationwide vaccination campaign in Israel: an 6736(21)00947‐ CoV‐2 observational study using national surveillance data 8/fulltext Horby et al. https://www.thelancet.c What is the effect of tocilizumab in Tocilizumab in patients admitted to hospital with (RECOVERY om/action/showPdf?pii= adult patients admitted to hospital 1‐May‐21 The Lancet COVID‐19 (RECOVERY): a randomised, controlled, RCT UK NCT04381936 Tocilizumab Collaborative S0140‐ with open‐label, platform trial Group) 6736%2821%2900676‐0 COVID‐19 Safety and immunogenicity of one versus two doses of https://www.thelancet.c To assess the safety and The Lancet the COVID‐19 vaccine BNT162b2 for patients with om/action/showPdf?pii= immunogenicity of the BNT162b2 27‐Apr‐21 Observational study UK Manin et al. NA BN162b2 vaccine Oncology cancer: interim analysis of a prospective observational S1470‐ (Pfizer–BioNTech) vaccine in study 2045%2821%2900213‐8 patients with cancer To evaluate the efficacy of the Lancet Ramakrishnan S., inhaled glucocorticoid widely used inhaled glucocorticoid 9‐Apr‐21 tment of early COVID 19 (STOIC): a phase 2, open‐lab RCT 2 phase UK ournals/lanres/article/PIIS NCT04416399 Respir Med. et al. budesonide budesonide in individuals with early COVID‐19 in the community. https://www.thelancet.c Efficacy of ChAdOx1 nCoV19 (AZD1222) vaccine post‐hoc analysis of the efficacy of om/journals/lancet/artic against SARS‐CoV‐2 variant of concern 202012/01 Emary K.R.W., et ChAdOx1 nCoV 19 the adenoviral vector vaccine, 30‐Mar‐21 Lancet vaccine UK le/PIIS0140‐ NCT04400838 (B.1.1.7): an exploratory analysis of a randomised al (AZD1222) vaccine ChAdOx1 nCoV‐19 (AZD1222), 6736(21)00628‐ controlled trial against the variant B.1.1.7. 0/fulltext Methylprednisolone or dexamethasone, which one https://bmcinfectdis.bio To assess the effectiveness of BMC is superior corticosteroid in the treatment of medcentral.com/articles IRCT202002040 Methylprednisolone methylprednisolone treatment 10‐Apr‐21 Infectious RCT Iran Ranjbar B hospitalized COVID‐19 patients: a triple‐blinded /10.1186/s12879‐021‐ 46369N1 or dexamethason versus dexamethasone for Diseases randomized controlled trial 06045‐3 hospitalized COVID‐19 patients. Two phase 1 and Immunogenicity and Safety of a SARS‐CoV‐2 phase 2 https://www.medrxiv.or To report the immunogenicity and NCT04758273 Inactivated Vaccine (KCONVAC) in Healthy Adults: randomized, double‐ g/content/10.1101/2021 safety of a SARS‐CoV‐2 inactivated 8‐Apr‐2021 MedRxiv China Pan H et al AND KCONVAC Two Randomized, Double‐blind, and Placebo‐ blind, and placebo‐ .04.07.21253850v1.full.p vaccine, KCONVAC, in healthy NCT04756323 controlled Phase 1/2 Clinical Trials controlled trials of df adults. KCONVAC INTERIM REPORT: SAFETY AND IMMUNOGENICITY https://www.medrxiv.or Interim analysis of a To evaluate safety parameters and OF AN INACTIVATED VACCINE AGAINST SARS‐COV‐2 g/content/10.1101/2021 1‐Apr‐2021 MedRxiv multicenter phase 3 Chile Bueno SM et al NCT04651790 CoronaVac immunogenicity against SARS‐CoV‐2 IN HEALTHY CHILEAN ADULTS IN A PHASE 3 .03.31.21254494v1.full.p CT after immunization with CoronaVac CLINICAL TRIAL df To assess the effect of oral Ivermectin treatment, which has been associated with iota‐ carrageenan in repeated doses A RANDOMIZED TRIAL ‐ INTENSIVE TREATMENT https://www.medrxiv.or through the nasal and BASED IN IVERMECTIN AND IOTA‐CARRAGEENAN g/content/10.1101/2021 Ivermectin / oral topical route, on the 30‐Mar‐2021 MedRxiv RCT Argentina Chahla RE et al NCT04701710 AS PRE‐EXPOSURE PROPHYLAXIS FOR COVID‐ 19 IN .03.26.21254398v1.full.p IotaCarrageenan appearance and eventual HEALTHCARE AGENTS df progression of COVID‐19 disease in a healthy population that are exposed to it and have a higher risk of contagion of SARS‐ COV‐2 To assess the use of a nasal spray Efficacy of a nasal spray containing Iota‐ https://www.medrxiv.or Nasal spray CARR‐COV2 Trial containing I‐C in the prophylaxis of Carrageenan in the prophylaxis of COVID‐ 19 in RCT g/content/10.1101/2021 containing Iota‐ 15‐Apr‐2021 MedRxiv Argentina Group NCT04521322 COVID‐19 in hospital personnel hospital personnel dedicated to patients care (CARR‐COV‐02) .04.13.21255409v1.full.p Carrageenan (I‐C) or dedicated to care of COVID‐19 collaborators df placebo for 21 days. with COVID‐19 disease patients to report the occurrence of https://www.medrxiv.or Performance of vaccination with CoronaVac in symptomatic COVID‐19 in a cohort g/content/10.1101/2021 15‐Apr‐2021 MedRxiv a cohort of healthcare workers (HCW) ‐ preliminary report Brazil De Faria E et al NA CoronaVac of healthcare workers (HCW) .04.12.21255308v1.full.p vaccinated with CoronaVac and to preliminary report df estimate its effectiveness. RBD‐specific polyclonal F(ab )2 fragments of equine phase 2/3, double‐ To analyze the safety and efficacy of antibodies in patients with moderate to severe https://www.ncbi.nlm.ni EClinicalMedi blind, placebo‐con‐ Equine poly‐ clonal specific anti SARS‐COV‐2 EpAbs in 8‐Apr‐2021 COVID‐19 disease: A randomized, multicenter, Argentina Lopardo et al h.gov/pmc/articles/PMC NCT04494984 cine trolled, multicenter antibodies (EpAbs) hospitalized patients with mod‐ double‐blind, placebo‐controlled, adaptive phase 8037439/pdf/main.pdf clinical erate and severe COVID‐19 disease 2/3 clinical trial Diphenhydramine Compound (Diphenhydramine + Quaternary ammonium compounds Int J of Effect of Ammonium Chloride in addition to double‐blind, single‐ https://pubmed.ncbi.nl Ammonium Chloride) have been demonstrated to have 12‐Apr‐2021 Infectious standard of care in outpatients and hospitalized Iran Siami Z et al NA center study m.nih.gov/33878462/ plus standard of care antiviral effects and may be of use Diseases COVID‐19 patients: a randomized clinical trial or Diphenhydramine against SARS‐CoV‐2 infections.
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