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A Step Towards Revising the Model for Vaccine Tuberculosis Immunity
COMMENTARY CONTEST Revising the model for vaccine development: a step towards tuberculosis immunity Amy Dagenais1 1University of Ottawa, Ottawa, Ontario, Canada Date Published: August 26, 2021 DOI: https://doi.org/10.18192/UOJM.V11iS1.5929 Keywords: Tuberculosis, COVID-19, vaccines hanks to accelerated vaccine development, the first with the largest infectious disease burden in the world, COVID-19 vaccine was approved for use by Health tolling 10 million new infections and 1.2 million deaths Canada only nine months after the disease was in 2019 alone.² Indeed, tuberculosis is one of the top 10 Tdeclared a pandemic by the World Health Organization.¹ causes of death worldwide—but the situation remains This unprecedented feat was made possible by three underdiscussed as most cases are recorded in developing critical factors: a stressed sense of urgency, substantial areas, such as South-East Asia (44%) and Africa (25%), or funding, and parallel pre-clinical and clinical trials. Such in underserved populations such as the Inuit in Canada.2,3 a concerted effort not only led to the development of Approximately one-quarter of the world population is multiple effective vaccines, but also bred innovation as infected by the etiological agent of tuberculosis: the mRNA technology bloomed despite its limited use in the bacterium Mycobacterium tuberculosis (Mtb), known as past. This success story paves the way for the accelerated the most successful human pathogen.² development of vaccines for other diseases, such as tuberculosis—the deadliest infectious disease of modern The intracellular pathogen has co-evolved with humans times before COVID-19 emerged. to evade host immune defenses, rendering TB treatment particularly difficult. -
CRAMPED for ROOM Mumbai’S Land Woes
CRAMPED FOR ROOM Mumbai’s land woes A PICTURE OF CONGESTION I n T h i s I s s u e The Brabourne Stadium, and in the background the Ambassador About a City Hotel, seen from atop the Hilton 2 Towers at Nariman Point. The story of Mumbai, its journey from seven sparsely inhabited islands to a thriving urban metropolis home to 14 million people, traced over a thousand years. Land Reclamation – Modes & Methods 12 A description of the various reclamation techniques COVER PAGE currently in use. Land Mafia In the absence of open maidans 16 in which to play, gully cricket Why land in Mumbai is more expensive than anywhere SUMAN SAURABH seems to have become Mumbai’s in the world. favourite sport. The Way Out 20 Where Mumbai is headed, a pointer to the future. PHOTOGRAPHS BY ARTICLES AND DESIGN BY AKSHAY VIJ THE GATEWAY OF INDIA, AND IN THE BACKGROUND BOMBAY PORT. About a City THE STORY OF MUMBAI Seven islands. Septuplets - seven unborn babies, waddling in a womb. A womb that we know more ordinarily as the Arabian Sea. Tied by a thin vestige of earth and rock – an umbilical cord of sorts – to the motherland. A kind mother. A cruel mother. A mother that has indulged as much as it has denied. A mother that has typically left the identity of the father in doubt. Like a whore. To speak of fathers who have fought for the right to sire: with each new pretender has come a new name. The babies have juggled many monikers, reflected in the schizophrenia the city seems to suffer from. -
Reliance Foundation and Municipal Corporation of Greater Mumbai to Provide Three Lakh Free COVID-19 Vaccines for Mumbai’S Underprivileged Communities
MEDIA RELEASE Reliance Foundation and Municipal Corporation of Greater Mumbai to provide three lakh free COVID-19 vaccines for Mumbai’s underprivileged communities • Communities across 50 locations including Dharavi, Worli, Wadala, Colaba, Kamatipura, Chembur to be covered • Reliance Foundation through Sir H N Reliance Foundation Hospital is deploying state-of-the-art mobile vehicle unit for the vaccination drive • Municipal Corporation of Greater Mumbai (MCGM) and BEST provide infrastructure & logistics support Mumbai, 2nd August 2021: In a major outreach scheme to protect Mumbai’s vulnerable communities, Reliance Foundation through Sir H N Reliance Foundation Hospital will collaborate with Municipal Corporation of Greater Mumbai (MCGM) to provide three lakh COVID-19 vaccination doses to communities across 50 locations in Mumbai. This free vaccination drive aims to protect underprivileged people in neighbourhoods including Dharavi, Worli, Wadala, Colaba, Pratiksha Nagar, Kamatipura, Mankhurd, Chembur, Govandi and Bhandup. Sir H N Reliance Foundation Hospital is deploying a state-of-the-art mobile vehicle unit to conduct the vaccination drive across the selected locations of Mumbai, while MCGM and BEST will provide infrastructure and logistics support for the drive. This initiative builds on Sir HN Reliance Foundation Hospital’s regular health outreach initiatives in Mumbai, which address primary and preventive healthcare needs of vulnerable populations through mobile medical vans and static medical units. This vaccination programme will be carried out over the next three months and is part of Reliance Foundation’s Mission Vaccine Suraksha initiative which will also provide vaccination for underprivileged communities around the country over the next few months. Smt Nita M Ambani, Founder and Chairperson, Reliance Foundation said: “Reliance Foundation has stood by the nation at every step of this relentless fight against the COVID- 19 pandemic. -
Sanjay Nirupam, 44
Do you know Who your MP is? SANJAY NiRUPAM Borivali Dahisar gURUDAS KanDivali MalaD kAMAt anDheri (e&w), GoreGaon, juhu, N joGeshwari (e&w), vile parle (w) NW NE PRiYA DUtt anDheri (e), BanDra (e&w), Chuna Bhati, Khar (e&w), Kurla, NC KherwaDi, tilaKnaGar, viDya vihar, SANJAY vile parle (e&w) DiNA santaCruz (e&w), SC PAtil BhanDup, CheMBur, WhAt GhatKopar, GovanDi, Kanjur MarG, KhinDi paDa DOES S ManKhurD, MulunD, troMBay, viDya vihar, AN MP viKhroli MiliND DEORA DO? ByCulla, MasjiD, Cst area, BunDer Charni rD, MazGaon, EkNAth gAikWAD ChinChpoKli, MuMBaDevi, ChurChGate, MuMBai Central, antop hill, MahiM, ColaBa, naGpaDa, CheMBur, MatunGa, Cotton Green, opera house, Chuna Bhati, nainGauM, Currey rD, parel, DaDar, parel, DoCKyarD rD, reay rD, Dharavi, praBhaDevi, elphinstone rD, sanDhurst rD, elphinstone sion, GirGauM, sewri, roaD, GovanDi, tilaK naGar, Grant roaD, tarDeo, GtB naGar, troMBay, KalBhaDevi Kh uMerKhaDi, KinG’s CirCle, waDala Marine lines, worli 2 3 mp profiles and to do’s areas promises performance public source performance self declared Corruption transport & infrastruCture stations ? ? quality ? ? sanjay nirupam, 44 ? INC, Mumbai North ? education: B.A. (Hons.), Political Science, A.N College, Patna employement history: Pancha Janya (Sub-Editor), Jan Satta, Dopahar Ka Samna (Executive Editor) health ? ? net assets: (Partially done) enviornment (Partially done) pending Court Cases: ? known to be defamatory ? ? ? -
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& ## - 3 ( "4 #""4 4 VRGR '%&((!1#VCEB R BP A"'!#$#1!$"$#$%T utqBVQWBuxy( 24526(*/ %114 6!7*8 %!5 $ ( " <--;-<',! 1+<1+.',!0++'+0,$- ;-,?-0<-+$1-+<-0 -.'1$9,: ;.:(0;.1;0,-+0< <0,$.'<0'(1< $.0,'!0<. /0!'+.9.00< :','02;'-, 0!0',+$.-+-0 -.<01, .=-<0;0>'/0=00 5 $ 0167223 778 50 +# - 0 $ +'$+"+(7 (+& facing other registration issues. ! While some said they were see- / 0 ing error messages while trying 11*2 ! to register, a few others com- plained they were not receiving ($*&$+$((" the OTP required to log in to New Delhi: Russia will deliver ,--.' ! * + CoWin on their phones. the first batch of Sputnik V vac- ,-&$)&$(%*. However, following the ini- cine to India on May 1, the day n a scathing criticism of the , ! tial trouble, the portal started the country expands its covid- +$"$,-&$+%*. IGovernment’s amended Q!" working after some time. 19 immunisation drive to cover ($)"$)%$*(* Covid treatment protocol relat- ! Aarogya Setu tweeted, “Cowin all adults from 18 years of age ed to anti-viral drug # Portal is working. There was a to 44. However, it is not clear ,-+$'$%. Remdesivir, the Delhi High minor glitch at 4 pm that was when the vaccine will be avail- Court on Wednesday observed ,--.' fixed. 18 plus can register”. able to the people here. &"$%($'/( “it appears you want people to $ #R At 4.54 pm, a tweet from “The first doses will be die”. s lack of vaccine stocks and the same handle stated, delivered on 1 May," Russian 2$%&$&' As per the amended pro- allocation was being made on Atheir availability in States “Vaccination appointments for Direct Investment Fund tocol, the Central Government the basis of the actual caseload remains an issue, the 18 plus will be possible once the (RDIF) chief executive officer # ($')$&%* submitted to the court that now of a State. -
Update 50 (15Th of December 2020)
Update 50 (15th of December 2020) Information about Infection disease COVID-19 (novel coronavirus) Force Health Protection Branch FHPB (former DHSC) NATO MILMED COE in Munich 15th of December 2020 email: [email protected] In December 2019, a novel coronavirus emerged in Wuhan City, China. Since then the virus spread to 65 countries including Europe and America. Since then the virus showed evidence for human-to-human transmission as well as evidence of asymptomatic transmission. At 30th January 2020 WHO declared a Public Health Emergency of International Concern. The disease was formally named COVID-19 on 11th of February. The virus itself has been named SARS-CoV-2. On 11th of March 2020 WHO characterized the disease as a pandemic. HIGHLIGHTS/NEWS GLOBALLY ↗ • GBR/WHO: A new variant of the virus could be responsible for the renewed high number of cases in the UK, among other things, which 72 879 777 confirmed cases could be "in connection with the faster spread in the south of England". 47 710 950 recovered So far, 1000 cases have been identified. 1 622 200 deaths The WHO emphasized that the new variant would now be examined. EU/EEA and the UK ↘ However, there is no evidence that the strain behaves differently than 21 936 276 existing virus types. "We saw many variants, this virus evolves and confirmed cases changes over time." 10 689 950 recovered • Sputnik V: The developers of the Russian coronavirus vaccine Sputnik 479 566 deaths V explain that it creates 91.4 percent protection against the lung disease USA ↗ Covid-19. -
Mla Ratings 2019
A comprehensive & objective rating of the Elected Representatives’ performance MLA RATINGS 2019 MUMBAI REPORT CARD Founded in 1998, the PRAJA Foundation is a non-partisan voluntary organisation which empowers the citizen to participate in governance by providing knowledge and enlisting people’s participation. PRAJA aims to provide ways in which the citizen can get politically active and involved beyond the ballot box, thus promoting transparency and accountability. Concerned about the lack of awareness and apathy of the local government among citizens, and hence the disinterest in its functioning, PRAJA seeks change. PRAJA strives to create awareness about the elected representatives and their constituencies. It aims to encourage the citizen to raise his/ her voice and influence the policy and working of the elected representative. This will eventually lead to efforts being directed by the elected representatives towards the specified causes of public interest. The PRAJA Foundation also strives to revive the waning spirit of Mumbai City, and increase the interaction between the citizens and the government. To facilitate this, PRAJA has created www.praja.org, a website where the citizen can not only discuss the issues that their constituencies face, but can also get in touch with their elected representatives directly. The website has been equipped with information such as: the issues faced by the ward, the elected representatives, the responses received and a discussion board, thus allowing an informed interaction between the citizens of the area. PRAJA’s goals are: empowering the citizens, elected representatives & government with facts and creating instruments of change to improve the quality of life of the citizens of India. -
Costal Road JTC.Pdf
CONTENTS CHAPTER 1 BACKGROUND 1.1 General: 1.2 Mumbai: Strengths and Constraints: 1.3 Transport Related Pollution: 1.4 Committee for Coastal Freeway: 1.5 Reference (TOR): 1.6 Meetings: CHAPTER 2 NEED OF A RING ROAD/ COASTAL FREEWAY FOR MUMBAI 2.1 Review of Past Studies: 2.2 Emphasis on CTS: 2.3 Transport Indicators 2.4 Share of Public Transport: 2.5 Congestion on Roads: 2.6 Coastal Freeways/ Ring Road: 2.7 Closer Examination of the Ring Road: 2.8 Reclamation Option: 2.9 CHAPTER 3 OPTIONS TOWARDS COMPOSITION OF COASTAL FREEWAY 3.1 Structural Options for Coastal Freeway: 3.2 Cost Economics: 3.3 Discussion regarding Options: 3.4 Scheme for Coastal Freeway: CHAPTER 4 COASTAL FREEWAY: SCHEME 4.1 4.2 Jagannath Bhosle Marg-NCPA(Nariman Point)-Malabar Hill-Haji Ali-Worli: 4.3 Bandra Worli: 4.4 Bandra Versova- Malad Stretch 4.5 Coastal road on the Gorai island to Virar: 4.6 Connectivity to Eastern Freeway: 4.7 Interchanges, Exits and Entries: 4.8 Widths of Roads and Reclamation: 4.9 Summary of the Scheme: 4.10 Schematic drawings of the alignment CHAPTER 5 ENVIRONMENTAL ASPECTS 5.1 Coastal Road Scheme: 5.2 Key Issue: Reclamation for Coastal Freeway: 5.3 Inputs received from CSIR-NIO: 5.4 Legislative Framework: 5.5 Further Studies: CHAPTER 6 POLICY INTERVENTIONS AND IMPLEMENTATION STRATEGY 6.1 Costs: 6.2 Funding and Construction through PPP/EPC Routes: 6.3 Maintenance Costs/ Funding: 6.4 Implementation Strategy: 6.5 Implementation Agency: 6.6 Construction Aspects: 6.7 Gardens, Green Spaces and Facilities: 6.8 Maintenance and Asset Management: CHAPTER -
Study of Housing Typologies in Mumbai
HOUSING TYPOLOGIES IN MUMBAI CRIT May 2007 HOUSING TYPOLOGIES IN MUMBAI CRIT May 2007 1 Research Team Prasad Shetty Rupali Gupte Ritesh Patil Aparna Parikh Neha Sabnis Benita Menezes CRIT would like to thank the Urban Age Programme, London School of Economics for providing financial support for this project. CRIT would also like to thank Yogita Lokhande, Chitra Venkatramani and Ubaid Ansari for their contributions in this project. Front Cover: Street in Fanaswadi, Inner City Area of Mumbai 2 Study of House Types in Mumbai As any other urban area with a dense history, Mumbai has several kinds of house types developed over various stages of its history. However, unlike in the case of many other cities all over the world, each one of its residences is invariably occupied by the city dwellers of this metropolis. Nothing is wasted or abandoned as old, unfitting, or dilapidated in this colossal economy. The housing condition of today’s Mumbai can be discussed through its various kinds of housing types, which form a bulk of the city’s lived spaces This study is intended towards making a compilation of house types in (and wherever relevant; around) Mumbai. House Type here means a generic representative form that helps in conceptualising all the houses that such a form represents. It is not a specific design executed by any important architect, which would be a-typical or unique. It is a form that is generated in a specific cultural epoch/condition. This generic ‘type’ can further have several variations and could be interestingly designed /interpreted / transformed by architects. -
A Case Study of Versova Bandra Sea Link
TRAVEL DEMAND FORECASTING FOR AN URBAN FREEWAYCORRIDOR: A CASE STUDY OF VERSOVA BANDRA SEA LINK CH SEKHARA RAO MOJJADA, CIVIL ENGINEERING SECTION, ONGC, GOA, [email protected] DHINGRA S L, INSTITUTE CHAIR PROFESSOR, IIT BOMBAY, [email protected] SRINIVAS G, TRANSPORTATION PLANNER, IBI GROUP, [email protected] This is an abridged version of the paper presented at the conference. The full version is being submitted elsewhere. Details on the full paper can be obtained from the author. Travel Demand Forecasting for an Urban Freeway Corridor: A case study of Versova Bandra Sea Link Ch Sekhara Rao, Mojjada; Dhingra, S L; Srinivas, G TRAVEL DEMAND FORECASTING FOR AN URBAN FREEWAYCORRIDOR: A CASE STUDY OF VERSOVA BANDRA SEA LINK Ch Sekhara Rao Mojjada, Civil Engineering Section, ONGC, Goa, [email protected] Dhingra S L, Institute Chair Professor, IIT Bombay, [email protected] Srinivas G, Transportation Planner, IBI Group, [email protected] ABSTRACT Transport demand is growing drastically in Indian cities due to increase in urbanization and migration from rural areas and smaller towns. Increase in household income, increase in commercial and industrial activities has further added to transport demand in metropolitan regions like Mumbai Metro Politian Region (MMR). Hence India is concentrating more on the urban infrastructure like construction of many expressways, freeways, BRTS etc. to accommodate the rapidly growing urbanization and also to get relieved from congestion. Many a times the geographical constraints also limit the opportunities for creating the infrastructure and force the government to build the transport infrastructure with very high investment through various PPR (Public Private Partnership) model. -
No. Sub Division Designation,Address & Telephone
No. Sub Division Designation,Address & Designation,Address & Designation,Address & Telephone Telephone Number of Assistant Telephone Number of Number of Government Information Information Officer Government Information Officer Officer 1 Office of the 1] Administrative Officer,Desk -1 1] Assistant Commissiner 1] Deputy Commissiner of Commissioner of {Confidential Br.},Office of the of Police,{Head Quarter- Police,{Head Quarter-1},Office of the Police,Mumbai Commissioner of Police, 1},Office of the Commissioner of Police, D.N.Road, D.N.Road,Mumbai-01,Telephone Commissioner of Police, Mumbai-01,Telephone No.2620043 No.22695451 D.N.Road, Mumbai-01, Telephone No.22624426 Confidential Report, Sr.Esstt., 2] Sr.Administrative Officer, Assistant Commissiner of Deputy Commissiner of Police, {Head Dept.Enquiry, Pay, Desk-3 {Sr.Esstt. Br.}, Office of Police, {Head Quarter- Quarter-1},Office of the Commissioner Licence, Welfare, the Commissioner of Police, 1},Office of the of Police, D.N.Road, Mumbai- Budget, Salary, D.N.Road,Mumbai-01, Telephone Commissioner of Police, 01,Telephone No.2620043 Retirdment No.22620810 D.N.Road, Mumbai-01, etc.Branches Telephone No.22624426 3] Sr.Administrative Officer,Desk - Assistant Commissiner of Deputy Commissiner of Police, {Head 5 {Dept.Enquiry} Br., Office of the Police, {Head Quarter- Quarter-1},Office of the Commissioner Commissioner of Police, 1},Office of the of Police, D.N.Road, Mumbai- D.N.Road,Mumbai-01,Telephone Commissioner of Police, 01,Telephone No.2620043 No.22611211 D.N.Road, Mumbai-01, Telephone -
Link 20-Apr-2021 JAMA Immunogenicity of the Ad26.COV2
07/052021 Date Journal Title Study type Country Authors Link Trial identifier Intervention Main question To evaluate the immunogenicity of the Ad26.COV2.S vaccine Ad26.COV2.S vaccine (Janssen/Johnson & Johnson) in Immunogenicity of the Ad26.COV2.S Vaccine for Stephenson KE et https://pubmed.ncbi.nl (by Janssen 20‐Apr‐2021 JAMA RCT USA NCT04436276 humans, including the kinetics, COVID‐19 al m.nih.gov/33704352/ Pharmaceutical magnitude, and phenotype of SARS‐ Companies) CoV‐2 spike‐specific humoral and cellular immune responses Combination of To compare the rate and time of Effect of a combination of nitazoxanide, https://www.ncbi.nlm.ni nitazoxanide, viral clearance in subjects receiving J of Medical ribavirin, and ivermectin plus zinc supplement h.gov/pmc/articles/PMC ribavirin, and the combination of nitazoxanide, 11‐Mar‐2021 CT Egypt Elalfy H et al NCT04392427 Virology (MANS.NRIZ study) on the clearance of mild 8014583/pdf/JMV‐9999‐ ivermectin plus Zinc ribavirin, and ivermectin plus zinc COVID‐19 0.pdf vs supportive versus those receiving supportive treatment treatment. XAV‐19 0.5 mg/kg at Pharmacokinetics and safety of XAV‐19, a day 1 and day 5 To assess the pharmacokinetics and https://www.medrxiv.or swine glyco‐humanized polyclonal anti‐ SARS‐ (group 1), 2 mg/kg at safety of XAV‐19, a swine glyco‐ g/content/10.1101/2021 20‐Apr‐2021 MedRxiv CoV‐2 antibody, for COVID‐19‐related RCT France Gaborit B et al NCT04453384 day 1 and day 5 humanized polyclonal antibody .04.15.21255549v1.full.p (group 2), 2 mg/kg at against SARS‐CoV‐2, in COVID‐19‐ moderate pneumonia: a randomized, double‐ df blind, placebo‐controlled, phase IIa study day 1 (group 3) or related moderate pneumonia placebo https://www.nejm.org/ To assest the Safety and Efficacy of Safety and Efficacy of Single‐Dose Ad26.COV2.S Vaccine RCT III 21‐Apr‐21 NEJM International Sadoff J et al.