Attentional Bias and Its Temporal Dynamics Among War Veterans Suffering from Chronic Pain: Investigating the Contribution of Post-Traumatic Stress Symptoms
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Attentional bias and its temporal dynamics among war veterans suffering from chronic pain: investigating the contribution of post-traumatic stress symptoms Mahdi Mazidi a,b, Kelsey Vig c,Seyran Ranjbar d,Mohammad-Reza Ebrahimi e, Ali Khatibi f* a Centre for the Advancement of Research on Emotion, The University of Western Australia, Crawley, WA, Australia b Department of Clinical Psychology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran c Department of Psychology, University of Regina, Regina, SK, Canada d Psychology Department, Shahid Beheshti University, Tehran, Iran e Military Psychiatry Center, 505 Psychiatric hospital, AJA University of Medical Sciences, Tehran, Iran f Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada * Corresponding Author: Ali Khatibi, [email protected], address: NW141, Montreal Neurological Institute, Montreal, Canada, Phone: +1-514-398-5564 Funding sources: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Conflict of interests: Authors declare no conflict of interest regarding the current submission 1 Abstract Background: Cognitive models propose that attentional dysregulation, including an attentional bias towards threat, is one of the factors through which chronic pain and post- traumatic stress symptoms (PTSS) maintain and exacerbate one another. The current investigation assessed the attentional bias for painful facial expressions and its relationship with PTSS, using both traditional and variability-based attentional bias measures, among veterans with chronic pain and PTSS and controls. Method: Fifty-four veterans with chronic pain and 30 age/education-matched controls participated in this investigation. Participants completed a self-report measure of PTSS and a modified version of the dot-probe task with painful, happy, and neutral facial expressions. Attention was assessed using both traditional and variability-based reaction time measures of attentional bias. Results: Veterans directed attention away from painful facial expressions (i.e., avoidance) relative to both the control group (between-subject effect) and relative to neutral faces (within- subject effect). Veterans also showed significantly elevated attentional bias variability for both happy and painful facial expressions compared to controls. Attentional bias variability for happy and painful facial expressions was correlated with PTSS among all participants. Conclusion: Veterans with chronic pain and PTSS avoided pain-related stimuli and displayed an overall attentional dysregulation for emotional facial expressions. Avoidance of pain cues may be a coping strategy that these individuals develop under stressful conditions. Implications, limitations, and directions for future research are discussed. Keywords: Attentional bias; trial-level bias score; post-traumatic stress disorder; chronic pain; veterans; dot-probe task 2 1. Introduction Various theoretical models include attentional biases (ABs), or the preferential allocation of attention towards or away from certain types of stimuli (Cisler & Koster, 2010), as important mechanisms influencing the development and maintenance of psychological disorders (Beck & Clark, 1997; Mathews & Mackintosh, 1998). ABs include hypervigilance, where attention is directed towards relevant stimuli, maintenance, where there is difficulty disengaging attention from relevant stimuli, and avoidance, where attention is directed away from relevant stimuli (Bar-Haim, Lamy, Pergamin, Bakermans-Kranenburg, & van IJzendoorn, 2007). Most of the research on AB and psychological disorders has examined an AB for threat in anxiety-related disorders, including post-traumatic stress disorder (PTSD). Some researchers describe the association between AB for threat and post-traumatic stress symptoms (PTSS) as a robust phenomenon (Buckley, Galovski, Blanchard, & Hickling, 2003; Constans, 2005) while others suggest that results supporting this association are mixed and weak at best (Schäfer, Zvielli, Hofler, Wittchen, & Bernstein, 2018). Several studies with null findings have been reported in the literature on the AB for threat and PTSS (e.g., Elsesser, Sartory, & Tackenberg, 2004, 2005), and failure to replicate significant findings is common in the AB literature (e.g., Kimble, Frueh, & Marks, 2009). Chronic pain has been described as pain that persists for at least 3 months and leads to functional impairment (International Association of the Study of Pain, 1986). Researchers and clinicians have largely shifted away from a purely biomedical understanding of chronic pain and moved towards a biopsychosocial perspective, including a focus on how cognition contributes to chronic pain. For example, the fear-avoidance model recognizes the important role of attentional processes in the maintenance of chronic pain (Crombez, Eccleston, Van Damme, Vlaeyen, & Karoly, 2012). When pain is acute, hypervigilance for pain information can be adaptive in the short-term and help the physical recovery process by encouraging 3 avoidance of behaviors that may cause further injury; but, hypervigilance and behavioral avoidance after the acute pain stage can lead to disuse of muscle and a lower pain threshold (Crombez et al., 2012). Despite theoretical support for chronic pain-related ABs, empirical support for these biases has been inconsistent. According to Crombez and colleagues (2013), there is a small (d = 0.134), but significant, within-group AB towards sensory pain words in individuals with chronic pain. Healthy controls did not demonstrate the same AB; however, there was no significant difference in the AB for pain-related stimuli between individuals with chronic pain and healthy controls. Chronic pain frequently co-occurs with anxiety disorders, and with PTSS in particular. An estimated 18.9% of individuals with chronic pain reported trauma exposure and PTSS (Ravn, Vaegter, Cardel, & Andersen, 2018). Prevalence estimates are even greater when examining specific populations. For example, recent reviews found that 50% of veterans with chronic pain also had PTSS (Fishbain, Pulikal, Lewis, & Gao, 2017; Siqveland, Hussain, Lindstrom, Ruud, & Hauff, 2017). Various theoretical models posit potential explanations for the association between chronic pain and PTSS/PTSD. The mutual maintenance model put forth by Sharp and Harvey (2001) suggests that chronic pain and PTSD maintain and exacerbate one another through specific cognitive, affective, and behavioral components (e.g., avoidance, attentional and reasoning biases). The shared vulnerability model proposed by Asmundson and colleagues (Asmundson, Coons, Taylor, & Katz, 2002; Asmundson & Katz, 2009) also includes ABs as one of the potential mechanisms that contribute to the co-occurrence of chronic pain and PTSD. However, once again, theoretical support exceeds empirical support as there is very little research examining ABs in individuals with comorbid chronic pain and PTSD. ABs towards pain-related stimuli have been demonstrated in individuals with chronic pain (e.g., Khatibi, Dehghani, Sharpe, Asmundson, & Pouretemad, 2009; Mahmoodi- 4 Aghdam, Dehghani, Ahmadi, Khorrami Banaraki, & Khatibi, 2017) and those with PTSS separately (e.g., Thomas, Goegan, Newman, Arndt, & Sears, 2013); however, to date, only two studies have investigated ABs in participants with comorbid chronic pain and PTSS. Researchers used the modified Stroop task, a variation of the original Stroop task (Stroop, 1935), with lists of emotionally salient (i.e., pain-related, trauma-related, and positive) and neutral words printed in various colors (Beck, Freeman, Shipherd, Hamblen, & Lackner, 2001). Participants were instructed to name the color of each word (e.g., “agony” written in blue). Longer RTs when reading emotionally salient words compared to neutral words indicates the presence of an AB (Bar-Haim et al., 2007). The modified Stroop task only provides an overall index of AB; that is, the paradigm cannot be used to assess the direction of an AB (i.e., hypervigilance, maintenance, or avoidance). The researchers compared biases across participants with comorbid chronic pain and PTSD, those with chronic pain only, and trauma-exposed controls (Beck et al., 2001). Individuals with comorbid chronic pain and PTSD and those with chronic pain only displayed an AB for pain-related words, as evidenced by both within- and between-group effects. In other words, individuals with chronic pain (with or without comorbid PTSD) responded slower to pain-related words compared to neutral or positive words, and they responded slower to pain-related words compared to trauma-exposed controls. More recently, researchers used the startle probe paradigm in combination with pain- related, trauma-related, health-related, pleasant, and neutral words to compare ABs in individuals with chronic pain alone, PTSD alone, comorbid chronic pain and PTSD, any other anxiety disorder, and trauma-exposed controls (Carleton, Duranceau, McMillan, & Asmundson, 2018). The researchers hypothesized that participants would display AB towards diagnosis-congruent stimuli (e.g., pain-related stimuli for participants with chronic pain), which were thought to be perceived as the most threatening. However, compared to participants 5 with anxiety disorders and the control group, individuals with PTSD or chronic pain showed greater startle intensity and delayed startle peak (responded more slowly, indicating higher fear-related reactivity)