Epidermolytic Acanthoma: a Case Report Ginsberg AS, Rajagopalan A, Terlizzi JP
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The Tamilnadu Dr. M.G.R. Medical University Chennai, Tamil Nadu
CLINICO-PATHOLOGICAL STUDY OF SKIN SURFACE EPIDERMAL AND APPENDAGEAL TUMOURS Dissertation Submitted in partial fulfillment of university regulations for M.D. DEGREE IN DERMATOLOGY, VENEREOLOGY AND LEPROSY BRANCH XII – A THE TAMILNADU DR. M.G.R. MEDICAL UNIVERSITY CHENNAI, TAMIL NADU SEPTEMBER 2006 CERTIFICATE This is to certify that this Dissertation entitled “CLINICO-PATHOLOGICAL STUDY OF SKIN SURFACE EPIDERMAL AND APPENDAGEAL TUMOURS” is a bonafide work done by DR.G.BALAJI, Postgraduate student of Department of Dermatology, Leprosy and Institute of STD, Madras Medical College and Government General Hospital, Chennai – 3 for the award of Degree of M.D.( Dermatology, Venereology and Leprosy ) Branch XII – A during the academic year of 2003-2006. This work has not previously formed in the basis for the award of any degree or diploma. Prof. Dr. B. Parveen, MD., DD., Professor & Head, Dept. of Dermatology and Leprosy, Madras Medical College & Govt. General Hospital, Chennai – 3. Prof. Dr. Kalavathy Ponniraivan, MD., The Dean Madras Medical College & Govt. General Hospital, Chennai – 3. SPECIAL ACKNOWLEDGEMENT I sincerely thank Prof. Dr. Kalavathy Ponniraivan, MD., Dean, Madras Medical College & Govt. General Hospital, Chennai – 3, for granting me permission to use the resources of this institution for my study. ACKNOWLEDGEMENT I sincerely thank Prof. B.Parveen MD.,DD, Professor and Head of Department of Dermatology for her invaluable guidance and encouragement for the successful completion of this study. I express my heart felt gratitude to Dr.N.Gomathy MD.,DD, former Head of department of Dermatology who was instrumental in the initiation of this project, giving constant guidance throughout my work. -
Cutaneous Horn: a Potentially Malignant Entity
Letter to the editor Cutaneous horn: a potentially malignant entity Cutaneous horn: a potentially malignant entity N. F. Fernandes, S. Sinha, W. C. Lambert, and R. A. Schwartz S UMMARY A cutaneous horn is a conical, dense, hyperkeratotic protrusion that often appears similar to the horn of an animal. It is a morphologic designation referring to an unusually cohesive keratinized material, not a true pathologic diagnosis. Cutaneous horns occur in association with, or as a re- sponse to, a wide variety of underlying benign, pre-malignant, and malignant cutaneous diseases. The most important common concern is distinguishing a hyperkeratotic actinic keratosis from a cutaneous squamous cell carcinoma. Keratoacanthoma is another cause, as illustrated herein as a projective cutaneous tumor with a fingernail-like appearance. The treatment of choice for cuta- neous horns is shave excision with subsequent histopathologic evaluation to rule out underlying malignancy and to guide potential further therapy. KEYIntroduction with the characterization of cutaneous horns as a WORDS medical disorder in the late eighteenth century (2). A cutaneous horn is a conical, dense hyperkeratotic cutaneous protrusion that often resembles the horn of an Epidemiology and etiology horn, cornu animal. The earliest documented case of cutaneous cutaneum, horn, or cornu cutaneum, was that of an elderly Welsh Cutaneous horns are nodules composed of hyperkerato- woman in London who was displayed commercially compact keratin that project above the surface of sis, actinic as an anomaly of nature in 1588 (1). There were the skin. They differ from animal horns by the keratosis, several other accounts of cutaneous horns in the absence of a central bone. -
Expert-Level Diagnosis of Nonpigmented Skin Cancer by Combined Convolutional Neural Networks
Supplementary Online Content Tschandl P, Rosendahl C, Akay BN, et al. Expert-level diagnosis of nonpigmented skin cancer by combined convolutional neural networks. JAMA Dermatol. Published online November 28, 2018. doi:10.1001/jamadermatol.2018.4378 eFigure. Sensitivities (Blue) and Specificities (Orange) at Different Threshold Cutoffs (Green) of the Combined Classifier Evaluated on the Validation Set eAppendix. Neural Network Training eTable 1. Complete List of Diagnoses and Their Frequencies Within the Test-Set eTable 2. Education of Users According to Their Experience Group eTable 3. Percent of Correct Prediction of the Malignancy Status for Specific Diagnoses of a CNN Using Either Close-up or Dermatoscopic Images This supplementary material has been provided by the authors to give readers additional information about their work. © 2018 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/25/2021 eFigure. Sensitivities (Blue) and Specificities (Orange) at Different Threshold Cutoffs (Green) of the Combined Classifier Evaluated on the Validation Set A threshold cut at 0.2 (black) is found for a minimum of 51.3% specificity. © 2018 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/25/2021 eAppendix. Neural Network Training We compared multiple architecture and training hyperparameter combinations in a grid-search fashion, and used only the single best performing network for dermoscopic and close-up images, based on validation accuracy, for further analyses. We trained four different CNN architectures (InceptionResNetV2, InceptionV3, Xception, ResNet50) and used model definitions and ImageNet pretrained weights as available in the Tensorflow (version 1.3.0)/ Keras (version 2.0.8) frameworks. -
Seborrheic Keratosis
Benign Epidermal and Dermal Tumors REAGAN ANDERSON, DO- PROGRAM DIRECTOR, COLORADO DERMATOLOGY INSTITUTE, RVU PGY3 RESIDENTS- JONATHAN BIELFIELD, GEORGE BRANT PGY2 RESIDENT- MICHELLE ELWAY Seborrheic Keratosis Common benign growth seen after third/fourth decade of life Ubiquitous among older individuals Tan to black, macular, papular, or verrucous lesion Occur everywhere except palms, soles, and mucous membranes Can simulate melanocytic neoplasms Pathogenesis: Sun exposure- Australian study found higher incidence in the head/neck Alteration in distribution of epidermal growth factors Somatic activating mutations in fibroblast growth factor receptor and phosphoinositide-3-kinase Seborrheic Keratosis Sign of Leser-Trelat: Rare cutaneous marker of internal malignancy • Gastric/colonic adenocarcinoma, breast carcinoma, and lymphoma m/c • Abrupt increase in number/size of SKs that can occur before, during, or after an internal malignancy is detected • 40% pruritus • M/C location is the back • Malignant acanthosis nigricans may also appear in 20% of patients • Should resolve when primary tumor is treated, and reappear with recurrence/mets Seborrheic Keratosis 6 Histologic types Acanthotic Hyperkeratotic Reticulated Irritated Clonal Melanoacanthoma Borst-Jadassohn phenomenon Well-demarcated nests of keratinocytes within the epidermis Seborrheic Keratoses Treatment Reassurance Irritated SKs (itching, catching on clothes, inflamed) Cryotherapy, curettage, shave excision Pulsed CO2, erbium:YAG lasers Electrodessication Flegel -
UC Davis Dermatology Online Journal
UC Davis Dermatology Online Journal Title Multiple acantholytic dyskeratotic acanthomas in a liver-transplant recipient Permalink https://escholarship.org/uc/item/24v5t78z Journal Dermatology Online Journal, 25(4) Authors Kanitakis, Jean Gouillon, Laurie Jullien, Denis et al. Publication Date 2019 DOI 10.5070/D3254043575 License https://creativecommons.org/licenses/by-nc-nd/4.0/ 4.0 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Volume 25 Number 4| April 2019| Dermatology Online Journal || Case Presentation 25(4):6 Multiple acantholytic dyskeratotic acanthomas in a liver- transplant recipient Jean Kanitakis1,2, Laurie Gouillon1, Denis Jullien1, Emilie Ducroux1 Affiliations: 1Department of Dermatology, Edouard Herriot Hospital Group, Lyon, France, 2Department of Pathology, Centre Hospitalier Lyon Sud, Pierre Bénite, France Corresponding Author: Jean Kanitakis, Department of Dermatology, Edouard Herriot Hospital Group (Pavillion R), 69437 Lyon cedex 03, France, Tel: 33-472110301, Email: [email protected] (0.5mg/d) and prednisolone (5mg/d). He had Abstract recently developed end-stage renal disease and was Acantholytic dyskeratotic acanthoma is a rare variant undergoing hemodialysis. His post-transplant of epidermal acanthoma characterized pathologically medical history was significant for two melanomas by the presence of acantholysis and dyskeratosis. (one in situ on the abdomen diagnosed at the age of Few cases have been reported until now, one of them 61 years and a superficial spreading melanoma in a heart-transplant patient. We present here a new 2.4mm Breslow thickness of the dorsum of the foot case of this rare lesion that developed in a liver- diagnosed ten years later), a squamous cell transplant patient and review the salient features of this uncommon condition. -
Common Skin Tumors
Topic Common Benign epidermal tumors Skin cyst and adnexal neoplasms skin tumors Other common skin tumor Common skin malignancy สมศกดั ิ์ ตนรั ตนากรั 26/02/2015 Seborrheic keratoses Benign Epidermal Tumors very common brown macules, papules, plaques, Seborrheic keratosis or polypoid lesions Dermatosis papulosa nigra over 40 y. Stucco keratosis increase number with age Inverted follicular keratosis Acrokeratosis verruciformis verrucous or 'stuck-on' the Clear cell acanthoma skin Large cell acanthoma predilection for face, neck, Porokeratosis and trunk Epidermal nevus Inflammatory linear verrucous epidermal nevus occur anywhere except Nevus comedonicus mucous membranes, palms, Epidermolytic acanthoma or soles Flegel’s disease sign of Leser-Trélat Cutaneous horn Lichenoid keratosis Acanthosis nigricans Confluent and reticulated papillomatosis Warty dyskeratoma Clinicopathologic Variants Common Seborrheic Keratosis Dermatosis Papulosa Nigra Skin Tags Irritated Seborrheic Keratosis Stucco Keratosis Reticulated Seborrheic Keratosis Clonal Seborrheic Keratoses Seborrheic Keratosis With Squamous Atypia Melanoacanthoma Leser-Trelat sign 1 Dermatosis papulosa nigra Seborrheic keratosis Skin tags Irritated Seborrheic Keratosis Stucco keratoses Epidermal nevi Multiple gray–white keratotic papules on ankle and benign hamartoma of epidermis and dorsal foot. papillary dermis onset usually within the first year of life asymptomatic well-circumscribed, hyperpigmented, papillomatous papules or plaques in a linear -
WO 2015/164427 Al 29 October 2015 (29.10.2015) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2015/164427 Al 29 October 2015 (29.10.2015) P O P C T (51) International Patent Classification: 11961 (US). NAGLER, Thomas; 1 Harborview Avenue, A61K 8/00 (2006.01) Greenlawn, New York 11740 (US). (21) International Application Number: (74) Agents: STAKLEFF, N. Nicole et al; Pepper Hamilton PCT/US20 15/026948 LLP, Suite 5000, 500 Grant Street, Pittsburgh, Pennsylvania 152 19-2507 (US). (22) International Filing Date: 2 1 April 2015 (21 .04.2015) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, English (25) Filing Language: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (26) Publication Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (30) Priority Data: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 61/982,217 2 1 April 2014 (21.04.2014) US KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 62/085,466 28 November 2014 (28. 11.2014) US MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (71) Applicant: ACLARIS THERAPEUTICS, INC. (heir of PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, the deceased inventor) [US/US]; 101 Lindenwood Drive, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, Malvern, Pennsylvania 19355 (US). -
Multiple Acantholytic Dyskeratotic Acanthomas in a Liver- Transplant Recipient
Volume 25 Number 4| April 2019| Dermatology Online Journal || Case Presentation 25(4):6 Multiple acantholytic dyskeratotic acanthomas in a liver- transplant recipient Jean Kanitakis1,2, Laurie Gouillon1, Denis Jullien1, Emilie Ducroux1 Affiliations: 1Department of Dermatology, Edouard Herriot Hospital Group, Lyon, France, 2Department of Pathology, Centre Hospitalier Lyon Sud, Pierre Bénite, France Corresponding Author: Jean Kanitakis, Department of Dermatology, Edouard Herriot Hospital Group (Pavillion R), 69437 Lyon cedex 03, France, Tel: 33-472110301, Email: [email protected] (0.5mg/d) and prednisolone (5mg/d). He had Abstract recently developed end-stage renal disease and was Acantholytic dyskeratotic acanthoma is a rare variant undergoing hemodialysis. His post-transplant of epidermal acanthoma characterized pathologically medical history was significant for two melanomas by the presence of acantholysis and dyskeratosis. (one in situ on the abdomen diagnosed at the age of Few cases have been reported until now, one of them 61 years and a superficial spreading melanoma in a heart-transplant patient. We present here a new 2.4mm Breslow thickness of the dorsum of the foot case of this rare lesion that developed in a liver- diagnosed ten years later), a squamous cell transplant patient and review the salient features of this uncommon condition. carcinoma of the cheek, a basal cell carcinoma and actinic keratosis of the ear, and an atypical nevus of the chest. He was seen in September 2018 (at 74 Keywords: acantholytic dyskeratotic acanthoma, years of age) for keratotic lesions of the back that had acantholysis, dyskeratosis, immunosuppression, organ been noticed recently. Physical examination showed transplantation some red-brown keratotic, asymptomatic papules grouped on the lower back, admixed with seborrheic Introduction keratoses and melanocytic nevi (Figure 1A). -
Dermatopathology A-Z Vladimir Vincek
Dermatopathology A-Z Vladimir Vincek Dermatopathology A-Z A Comprehensive Guide Vladimir Vincek Department of Dermatology College of Medicine University of Florida Gainesville, FL USA ISBN 978-3-319-89485-0 ISBN 978-3-319-89486-7 (eBook) https://doi.org/10.1007/978-3-319-89486-7 Library of Congress Control Number: 2018951196 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland This book is dedicated to my parents, who provided me with an enriching childhood, to my wife for all of her patience, understanding, and support, and to my children for some unforgettable moments that always brighten my days. -
Linear Epidermolytic Acanthoma of Vulva: an Unusual Presentation
Case LLinearinear eepidermolyticpidermolytic acanthomaacanthoma ofof vulva:vulva: Report AAnn uunusualnusual ppresentationresentation MMollyolly TThomas,homas, RRenuenu GGeorge,eorge, MeeraMeera TThomashomas1 Department of Dermatology, ABSTRACT Venereology and Leprosy, 1Department of Pathology, Epidermolytic acanthoma (EA) is a rare benign tumor that shows epidermolytic hyperkeratosis Christian Medical College and Hospital, Vellore, India (EH) on histopathology. It can occur in a solitary or disseminated form. This condition needs to be distinguished from other hereditary or acquired conditions that may show EH. We AAddressddress forfor ccorrespondence:orrespondence: diagnosed an unusual case of EA of the vulva presenting in a linear pattern in a 50-year-old Dr. Renu George, lady based on the clinical features and typical histopathological fi ndings and stress the Department of Dermatology, importance of considering epidermolyic acanthoma in the differential diagnosis of verrucous Venereology and Leprosy, lesions of the genitalia. Christian Medical College and Hospital, Vellore - 632 004, India. Key words: Acanthoma, epidermolytic, linear, vulva E-mail: renuegeorge@gmail. com DOI: 10.4103/0378-6323.58679 PMID: 20061731 IINTRODUCTIONNTRODUCTION majora with extension to the thigh and perineum over a period of a few years. She had no other comorbidities Epidermolytic hyperkeratosis (EH) is an abnormality nor any history of extramarital exposures. There of epidermal maturation characterized by compact was no family history of any ichthyosiform disorder. hyperkeratosis, accompanied by granular and Cutaneous examination revealed a hyperpigmented vacuolar degeneration of the cells of the spinous linear greyish-white verrucous plaque involving the and granular layer. It is associated with solitary or outer aspect of the labia majora on the left side. Few widespread cutaneous diseases of an inherited or verrucous papules extended to the adjacent thigh and acquired nature.[1] Among the acquired conditions, the perineum [Figure 1]. -
21 Genodermatoses
. 21 . 21.2 The Ichthyoses 21 Genodermatoses Although this chapter is devoted to genodermatoses, many acquired disorders are also considered when they seem to fit into the general clinical picture. For example, acquired forms of porokeratosis are considered along with the less common in- herited ones. Genodermatoses 21.1 MIM Code What..................................................................................... is the MIM Code? Victor A. McKusick, one of the giants of clinical human genetics, started using a numerical code when he began compiling his books entitled Mendelian Inheritance in Man. The books evolved into a website, OMIM (Online Mendelian Inheritance in Man), which today serves as the standard for clinical genetics and the most convenient way to acquire updated information on all genetic disorders. The MIM code is given throughout this book whenever it is relevant. The first digit identifies the pattern of diagnosis: 1 = autosomal dominant inheritance; 2 = auto- somal recessive inheritance; 3 = X-linked inheritance. .....................................................................................How to Use OMIM 1 Simply enter ONIM in Google or any search engine and you will land on OMIM—or enter www.ncbi.nlm.nih.gov/OMIM. 2 Search OMIM. 3 Enter the MIM code, or a key word or two if you are looking for a syndrome or set of findings. 4 You will see a list of disease descriptions likely to be relevant to your query; chose whichever ones seem most useful. 5 Now you can read an update about the disease, the gene, find extensive references, or be linked to Medline. 21.2 The Ichthyoses Overview..................................................................................... The primary ichthyoses are a heterogenous group of inherited disorders featuring ex- cessive scale. -
0 B Skin Pages1-8
Contents 1Keratinocytic tumours 9 Persistent melanoma and local WHO and TNM classification 10 metastasis of melanoma 90 Introduction 11 Congenital melanocytic naevus 93 Basal cell carcinoma 13 Superficial type 93 Superficial basal cell carcinoma 15 Proliferative nodules in congenital Nodular basal cell carcinoma 16 melanocytic naevi 93 Micronodular basal cell carcinoma 16 Blue naevi 95 Infiltrating basal cell carcinoma 17 Common blue naevus 95 Fibroepithelial basal cell carcinoma 17 Mongolian spot 96 Basal cell carcinoma with adnexal differentiation 18 Naevus of Ito and naevus of Ota 96 Basosquamous carcinoma 18 Cellular blue naevus 96 Keratotic basal cell carcinoma 19 Deep penetrating naevus 98 Other variants 19 Combined naevus 100 Squamous cell carcinoma 20 Melanotic macules 103 Acantholytic squamous cell carcinoma 21 Simple lentigo – lentiginous melanocytic naevus 104 Spindle-cell squamous cell carcinoma 22 Dysplastic naevus 105 Verrucous squamous cell carcinoma 22 Site specific and Meyerson naevi 110 Pseudovascular squamous cell carcinoma 23 Acral naevus 110 Adenosquamous carcinoma 24 Genital naevus 110 Bowen disease 26 Meyerson naevus 111 Bowenoid papulosis 28 Persistent (recurrent) melanocytic naevus 113 Actinic keratosis 30 Spitz naevus 114 Arsenical keratosis 32 Pigmented spindle cell naevus (Reed) 117 PUVA keratosis 33 Halo naevus 118 Verrucas 34 Verruca vulgaris 36 3 Appendageal tumours 121 Verruca plantaris 37 WHO and TNM classification 122 Verruca plana 38 Introduction 123 Acanthomas 39 Malignant tumours with apocrine and Epidermolytic