DOCSLIB.ORG

0 B Skin Pages1-8

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
0 B Skin Pages1-8 Contents 1Keratinocytic tumours 9 Persistent melanoma and local WHO and TNM classification 10 metastasis of melanoma 90 Introduction 11 Congenital melanocytic naevus 93 Basal cell carcinoma 13 Superficial type 93 Superficial basal cell carcinoma 15 Proliferative nodules in congenital Nodular basal cell carcinoma 16 melanocytic naevi 93 Micronodular basal cell carcinoma 16 Blue naevi 95 Infiltrating basal cell carcinoma 17 Common blue naevus 95 Fibroepithelial basal cell carcinoma 17 Mongolian spot 96 Basal cell carcinoma with adnexal differentiation 18 Naevus of Ito and naevus of Ota 96 Basosquamous carcinoma 18 Cellular blue naevus 96 Keratotic basal cell carcinoma 19 Deep penetrating naevus 98 Other variants 19 Combined naevus 100 Squamous cell carcinoma 20 Melanotic macules 103 Acantholytic squamous cell carcinoma 21 Simple lentigo – lentiginous melanocytic naevus 104 Spindle-cell squamous cell carcinoma 22 Dysplastic naevus 105 Verrucous squamous cell carcinoma 22 Site specific and Meyerson naevi 110 Pseudovascular squamous cell carcinoma 23 Acral naevus 110 Adenosquamous carcinoma 24 Genital naevus 110 Bowen disease 26 Meyerson naevus 111 Bowenoid papulosis 28 Persistent (recurrent) melanocytic naevus 113 Actinic keratosis 30 Spitz naevus 114 Arsenical keratosis 32 Pigmented spindle cell naevus (Reed) 117 PUVA keratosis 33 Halo naevus 118 Verrucas 34 Verruca vulgaris 36 3 Appendageal tumours 121 Verruca plantaris 37 WHO and TNM classification 122 Verruca plana 38 Introduction 123 Acanthomas 39 Malignant tumours with apocrine and Epidermolytic acanthoma 39 eccrine differentiaton 125 Warty dyskeratoma 39 Tubular carcinoma 125 Acantholytic acanthoma 40 Microcystic adnexal carcinoma 125 Lentigo simplex 40 Malignant mixed tumour 127 Seborrhoeic keratosis 41 Porocarcinoma 128 Melanoacanthoma 43 Spiradenocarcinoma 130 Clear cell acanthoma 43 Hidradenocarcinoma 131 Large cell acanthoma 44 Mucinous carcinoma 131 Keratoacanthoma 44 Digital papillary carcinoma 133 Lichen planus-like keratosis 47 Adenoid cystic carcinoma 134 Apocrine carcinoma 135 2 Melanocytic tumours 49 Paget disease and extramammary WHO classification 50 Paget disease 136 TNM classification 51 Benign tumours with apocrine and Malignant melanoma: Introduction 52 eccrine differentiation 139 Superficial spreading melanoma 66 Hidrocystoma 139 Nodular melanoma 68 Syringoma 140 Lentigo maligna 70 Poroma 141 Acral-lentiginous melanoma 73 Syringofibroadenoma 142 Desmoplastic melanoma and desmoplastic Hidradenoma 143 neurotropic melanoma 76 Spiradenoma 143 Melanoma arising from blue naevus 79 Cylindroma 145 Melanoma arising in giant congenital naevi 83 Tubular and tubular papillary adenoma 145 Childhood melanoma 84 Syringocystadenoma papilliferum 146 Naevoid melanoma 86 Hidradenoma papilliferum 147 Mixed tumour (chondroid syringoma) 147 B-cell lymphoma 199 Malignant tumours with follicular differentiation 149 Intravascular large B-cell lymphoma 200 Pilomatrical carcinoma 149 Lymphomatoid granulomatosis 202 Proliferating tricholemmal tumour 150 Cutaneous involvement in primary extracutaneous Benign tumours with follicular differentiation 152 B-cell lymphoma 204 Trichoblastoma 152 Mantle cell lymphoma 204 Pilomatricoma 153 Burkitt lymphoma 205 Tricholemmoma 155 Chronic lymphocytic leukaemia / small Trichofolliculoma 156 lymphocytic lymphoma 205 Pilar sheath acanthoma 157 Hodgkin lymphoma 207 Tumour of the follicular infundibulum 158 Blastic NK-cell lymphoma 208 Fibrofolliculoma / trichodiscoma 158 Precursor T-lymphoblastic leukaemia / lymphoma Tumours with sebaceous differentiation 160 and precursor B-lymphoblastic Sebaceous carcinoma 160 leukaemia / lymphoma 210 Sebaceous adenoma 161 Cutaneous involvement by myeloid leukaemia 211 Sebaceoma 162 Lymphoid infiltrates of the skin mimicking Cystic sebaceous tumour 163 lymphoma 212 Parapsoriasis 215 4 Haematolymphoid tumours 165 Small plaque parapsoriasis 215 WHO / EORTC classification 166 Parapsoriasis – Large patch type, TNM classification 167 with or without poikiloderma 215 Introduction 168 Langerhans cell histiocytosis 217 Mycosis fungoides (MF) 169 Indeterminate cell histiocytosis 220 Pagetoid reticulosis 173 Sinus histiocytosis with massive lymphadenopathy Syringotropic MF 173 (Rosai-Dorfman) 221 Folliculotropic MF 173 Juvenile xanthogranuloma 222 Granulomatous MF 174 Reticulohistiocytosis 224 Sézary syndrome 175 Mastocytosis 226 Granulomatous slack skin 178 CD30+ T-cell lymphoproliferative disorders 179 5 Soft tissue tumours 229 Lymphomatoid papulosis (LyP) 179 WHO and TNM classification 230 Primary cutaneous anaplastic large-cell Introduction 231 lymphoma 180 Vascular tumours 233 Subcutaneous panniculitis-like T-cell lymphoma 182 Haemangioma of infancy 233 Primary cutaneous peripheral T-cell lymphoma, Cherry haemangioma 233 unspecified 184 Sinusoidal haemangioma 234 Cutaneous γδ T-cell lymphoma 184 Hobnail haemangioma 234 Primary cutaneous aggressive epidermotropic Glomeruloid haemangioma 235 CD8+ cytotoxic T-cell lymphoma 185 Microvenular haemangioma 236 Primary cutaneous small-medium CD4+ T-cell Angiolymphoid hyperplasia with eosinophilia 237 lymphoma 186 Spindle cell haemangioma 239 Primary cutaneous PTL, unspecified 186 Tufted angioma 239 Cutaneous adult T-cell leukaemia / lymphoma 189 Bacillary angiomatosis 240 Extranodal NK/T-cell lymphoma, nasal-type 191 Reactive angioendotheliomatosis 241 Hydroa vacciniforme-like cutaneous T-cell Verrucous haemangioma 242 lymphoma 192 Pyogenic granuloma 243 Cutaneous involvement in primary extracutaneous Cavernous haemangioma 243 T-cell lymphoma 193 Angiokeratomas 244 Systemic anaplastic large cell lymphoma (ALCL) 193 Arteriovenous haemangioma 245 Angioimmunoblastic T-cell lymphoma (AITL) 193 Cutaneous angiosarcoma 246 Cutaneous marginal zone B-cell lymphoma 194 Lymphatic tumours 247 Cutaneous follicle centre lymphoma 196 Lymphangioma circumscriptum 247 Cutaneous diffuse large B-cell lymphoma 198 Progressive lymphangioma 248 Diffuse large B-cell lymphoma, leg-type 198 Lymphangiomatosis 249 Diffuse large B-cell lymphoma, other 198 Smooth and skeletal muscle tumours 250 T-cell / histiocyte-rich large B-cell lymphoma 199 Smooth muscle hamartoma 250 Plasmablastic lymphoma 199 Pilar leiomyoma 251 Secondary skin involvement by diffuse large Cutaneous leiomyosarcoma 251 Rhabdomyomatous mesenchymal hamartoma 252 Fibrous, fibrohistiocytic and histiocytic tumours 254 Keloid scar 254 Hypertrophic scar 254 Dermatomyofibroma 255 Infantile myofibromatosis 256 Sclerotic fibroma 256 Digital mucous cyst 257 Digital fibrokeratoma 257 Pleomorphic fibroma 258 Giant cell fibroblastoma 258 Dermatofibrosarcoma protuberans 259 Dermatofibroma (fibrous histiocytoma) 261 6 Neural tumours 263 WHO and TNM classification 264 Palisaded, encapsulated neuroma and traumatic neuroma 265 Palisaded encapsulated neuroma 265 Traumatic neuroma 266 Primary malignant peripheral primitive neuroectodermal tumour (PNET) / Extraskeletal Ewing sarcoma (ES) 268 Nerve sheath myxoma / neurothekeoma 270 Merkel cell carcinoma 272 Granular cell tumour 274 7 Inherited tumour syndromes 277 Familial cutaneous melanoma 279 Xeroderma pigmentosum 282 Naevoid basal cell carcinoma (Gorlin) syndrome 285 Cowden syndrome 288 Carney complex 291 Contributors 295 Source of charts and photographs 300 References 301 Subject index 341.
Load more

Recommended publications
  • Atypical Compound Nevus Arising in Mature Cystic Ovarian Teratoma
    J Cutan Pathol 2005: 32: 71–123 Copyright # Blackwell Munksgaard 2005 Blackwell Munksgaard. Printed in Denmark Journal of Cutaneous Pathology Abstracts of the Papers Presented at the 41st Annual Meeting of The American Society of Dermatopathology Westin Copley Place Boston, Massachusetts, USA October 14–17, 2004 These abstracts were presented in oral or poster format at the 41st Annual Meeting of The American Society of Dermatopathology on October 14–17, 2004. They are listed on the following pages in alphabetical order by the first author’s last name. 71 Abstracts IN SITU HYBRIDIZATION IS A VALUABLE DIAGNOSTIC A 37-year-old woman with diagnosis of Sjogren’s syndrome (SS) TOOL IN CUTANEOUS DEEP FUNGAL INFECTIONS presented with asymptomatic non-palpable purpura of the lower J.J. Abbott1, K.L. Hamacher2,A.G.Bridges2 and I. Ahmed1,2 extremities. Biopsy of a purpuric macule revealed a perivascular Departments of Laboratory Medicine and Pathology1 and and focally nodular lymphocytic infiltrate with large numbers of Dermatology2, plasma cells, seemingly around eccrine glands. There was no vascu- litis. The histologic findings in the skin were strikingly similar to those Mayo Clinic and Mayo Foundation, Rochester, MN, USA of salivary, parotid, and other ‘‘secretory’’ glands affected in SS. The cutaneous manifestations of SS highlighted in textbooks include Dimorphic fungal infections (histoplasmosis, blastomycosis, coccidiomy- xerosis, annular erythema, small-vessel vasculitis, and pigmented cosis, and cryptococcosis) can occur in immunocompromised and purpura. This case illustrates that purpura in skin of patients with healthy individuals. Cutaneous involvement is often secondary and SS may be caused by a peri-eccrine plasma-rich infiltrate.
    [Show full text]
  • Malignant Hidradenoma: a Report of Two Cases and Review of the Literature
    ANTICANCER RESEARCH 26: 2217-2220 (2006) Malignant Hidradenoma: A Report of Two Cases and Review of the Literature I.E. LIAPAKIS1, D.P. KORKOLIS2, A. KOUTSOUMBI3, A. FIDA3, G. KOKKALIS1 and P.P. VASSILOPOULOS2 1Department of Plastic and Reconstructive Surgery, 2First Department of Surgical Oncology and 3Department of Surgical Pathology, Hellenic Anticancer Institute, "Saint Savvas" Hospital, Athens, Greece Abstract. Introduction: Malignant tumors of the sweat glands difficult (1). Clear cell hidradenoma is an extremely rare are very rare. Clear cell hidradenoma is a lesion with tumor with less than 50 cases reported (2, 3). histopathological features resembling those of eccrine poroma The cases of two patients, suffering from aggressive and eccrine spiradenoma. The biological behavior of the tumor dermal lesions invading the abdominal wall and the axillary is aggressive, with local recurrences reported in more than 50% region, are described here. Surgical resection and of the surgically-treated cases. Materials and Methods: Two histopathological examination ascertained the presence of patients are presented, the first with tumor in the right axillary malignant clear cell hidradenoma. In addition to these region, the second with a recurrent tumor of the abdominal cases, a review of the literature is also presented. wall. The first patient underwent wide excision with clear margins and axillary lymph node dissection and the second Case Reports patient underwent wide excision of the primary lesion and bilateral inguinal node dissection due to palpable nodes. Patient 1. Patient 1 was a 68-year-old Caucasian male who had Results: The patients had uneventful postoperative courses. No undergone excision of a rapidly growing, ulcerous lesion of the additional treatment was administered.
    [Show full text]
  • Malignant Nodular Hidradenoma-Inguinal Region Clinically Masquerading As Squamous Cell Carcinoma: a Case Report
    International Journal of Research in Medical Sciences Vernekar S et al. Int J Res Med Sci. 2019 Jul;7(7):2848-2852 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20192933 Case Report Malignant nodular hidradenoma-inguinal region clinically masquerading as squamous cell carcinoma: a case report Sunita S. Vernekar, Priyadharshini Bargunam* Department of Pathology, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India Received: 24 April 2019 Accepted: 05 June 2019 *Correspondence: Dr. Priyadharshini Bargunam, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Malignant Nodular hidradenoma is an extremely rare aggressive tumour originating from eccrine sweat glands with an incidence of <.001%. So far less than 80 cases have been reported in the literature. It’s known for its local recurrence (50%) and metastasis (60%) and hence early diagnosis and radical treatment is mandatory. But differentiating it from its benign counterparts and other skin tumour mimics is challenging, due to its histopathological similarity & lack of diagnostic immunomarkers. Authors report a case of 65-year-old female who presented with a short 4-month history of rapidly growing ulceroproliferative growth in the right inguinal region with bilateral inguinal node enlargement, associated with pain and discharge. Wedge biopsy of left inguinal lymph node showed malignant cutaneous adnexal tumour deposits, which after excision was typed as malignant nodular hidradenoma.
    [Show full text]
  • Sample Research Poster
    Surgical management and lymph node biopsy of rare malignant cutaneous adnexal carcinomas: a population-based analysis of 7591 patients Amrita Goyal MD, 1 Theodore Marghitu,2 Nikhil Goyal BS,3 Nathan Rubin MS,4 Krishnan Patel MD,6 Kavita Goyal MD,1 Daniel O’Leary MD,5 Kimberly Bohjanen MD, 1 Ian Maher MD 1 1Department of Dermatology, University of Minnesota, Minneapolis, MN 2University of Minnesota Medical School, Minneapolis, MN 3National Institutes of Health/National Cancer Institute, Bethesda, MD 4Biostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis MN 5Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 6Department of Radiation Oncology, University of Minnesota, Minneapolis, MN Background Overall and Disease-Specific Survival Lymph Node Biopsy and Survival Cutaneous adnexal carcinomas comprise a group of Vital status* All Sweat Hidradenocarc Spiradenocarci Sclerosin Porocarcin Eccrine Sebaceous Lymph Nodes All adnexal tumors adnexal gland inoma noma g sweat oma adenocarci carcinoma Lymph Nodes Examined carcino duct noma Nodes not examined 6592 (91.9) rare cutaneous malignancies that are generally ma tumor Nodes examined 578 (8.1) (MAC) Positive (% of examined) 138 (23.9) considered non-aggressive. Guidelines for the Stage (Derived AJCC N=1863 N=70 N=127 N=46 N=236 N=229 N=187 N=968 Negative (% of examined) 440 (76.1) Stage Group, 6th ed treatment of many of these malignancies are sparse, (2004-2015) Total N=1221 5-year OS 5-year DSS 1,2 I 1221 40 (57.1) 56 (44.1) 14 (30.4) 150 140 (61.1) 103 (55.1) 718 (74.2) Stage I Examined N=112 including guidance on surgical management (65.5) (63.6) Nodes not examined (% of total) 1109 (90.8) 69.7 (66.1-72.4) 99.3 (99.6-100) 3,4 II 440 14 (20.0) 54 (47.5) 28 (60.9) 47 (19.9) 64 (27.9) 51 (27.3) 182 (18.8) Nodes positive (% of examined) 0 (0) -- -- including the utility of lymph node biopsy.
    [Show full text]
  • 第32回日本皮膚病理組織学会学術大会 診断投票結果 口演 1 Drug Eruption 13, うち Erythema Multif
    第３２回日本皮膚病理組織学会学術大会 診断投票結果 口演 1 Drug eruption 13, うち erythema multiforme 1, Interface dermatitis 1, GVHD type 1 Cutaneous reaction due to CCR4 3, うち Dysplastic epidermal hyperplasia 2, Adverse reaction 1 Erythema multiforme 3 PLEVA 1 Vacuolar type interface dermatitis 1 口演 2 Syringofibroadenoma 15, うち + amyloid 1 Syringofibroadenoma with BCC 5 Basal cell carcinoma 4, うち Pinkus type of BCC with syringofibroadenoma 2 口演 3 Darier disease 5 Hailey-Hailey disease 4 Pemphigus 3, うち Pemphigus Vegetans 1, Neonatal pemphigus 1 Grover's disease 4 Epidermal nevus 5, うち Acantholytic (dyskeratotic) epidermal nevus 4, Linear epidermal nevus 1 口演 4 Hydradenoma 13, うち Clear cell hidradenoma 12, Nodular hidradenoma 1 Sebaceous adenoma 1 Trichilemmoma 1 Metastatic tumor 8, うち ～ renal carcinoma6, ～ Clear cell carcinoma 2 口演 5 Apocrine carcinoma 3, うち ～with pagetoid spreading 2 Ectopic breast carcinoma(invasive ductal type)with pagetoid phenomenon 2 Extramammary Paget's disease 12, うち Paget carcinoma 3, ～ with Apocrine adenoma 2, ～ with Tubular adenoma 1, Invasive ～ 1, +Skin metastasis 1, With syringoma 1, with Microcystic Adnexal Carcinoma 1 Syringomatous carcinoma 2, うち ～with paget phenomenon 1 Tubular adenocartinoma 1 Tubular (apocrine) adenoma 2 Syringoma 1 口演 6 Dermatofibroma 10, うち Lipidized ～ 3, Hemosiderotic deep cellular ～ 2, Xanthomatous ～ 1, ～ Histiocytoid variant 1 Fibous histiocytoma 8, うち Atypical ～ 3, Malignant ～ 2, Aneurismal ～ 2 Undifferentiated pleomorphic sarcoma 2 Progressive nodular histiocytosis 1 Squamous
    [Show full text]
  • An Institutional Experience
    Original Research Article Skin Adnexal Tumors- An Institutional Experience 1 2* 3 4 5 6 Rekha M Haravi , Roopa K N , Priya Patil , Rujuta Datar , Meena N Jadhav , Shreekant K Kittur 1,5Associate Professor, 2Post Graduate Student, 3,4Assistant Professor, 6Professor & HOD, Department of Pathology, Belgaum Institute of Medical Sciences Dr B R Ambedkar Road, Belagavi, Karnataka – 590001, INDIA. Email: [email protected] Abstract Background: Skin adnexal tumors are a wide spectrum of benign and malignant tumors that differentiate towards one or more adnexal structures found in normal skin. The adnexal structures of skin are the hair follicles, sebaceous glands, eccrine and apocrine sweat glands. These skin adnexal tumors are often difficult to diagnose clinically. This retrospective study was undertaken to know the various histomorphological patterns of skin adnexal tumors at our institution and to determine the incidence among the genders and age groups along with the site distribution. Materials and methods: A total of 40 specimens received and diagnosed as skin adnexal tumors in the department of Pathology at Belgaum Institute of Medical Sciences, Belagavi for a period of 6 years from January 2014 to December 2019 were taken for the study. Histopathological slides prepared from tissue blocks retrieved from departmental archives were reviewed and classified according to the WHO classification 2017. Results: Out of the total 40 samples, benign tumors were 36 (90%) and malignant were 4 (10%). Largest group was the benign tumors of apocrine and eccrine differentiation (47.5%) followed by benign tumors of hair follicle differentiation (40%). Malignant tumors of sebaceous differentiation were 5%, malignant tumors of eccrine and apocrine differentiation were 2.5% and malignant hair follicle differentiation tumors were 2.5% of the total.
    [Show full text]
  • Pilar Sheath Acanthoma Presenting As a Nevus
    Letter to Editor Pilar Sheath Acanthoma Presenting as a Nevus Sir, Pilar sheath acanthoma (PSA) is a rare benign follicular neoplasm, which was first described by Mehregan and Brownstein in 1978.[1] PSA usually presents as an asymptomatic, flesh colored papule with a central opening localized at the lower lip with exceptional presentations such as ear lobe, postauricular region, or cheek.[1‑3] A 42‑year‑old female referred with a solitary, slow‑growing nodular lesion at the upper lip region for 6 months. Physical exam revealed a 4 mm, pink‑brown colored nodule with a central opening [Figure 1]. Under clinical prediagnosis of melanocytic nevus, an excisional biopsy Figure 1: Physical examination of the nodule in the upper lip region was performed. In a microscopic examination, a cystic cavity that communicated with surface epidermis has been observed. The wall of the cystic cavity was composed of solid tumor islands extending in the deep dermis [Figure 2]. The cavity was lined with stratified squamous epithelium filled with keratin [Figure 3]. PSA is an uncommon, benign follicular tumor occurring in the faces of middle‑aged and elderly patients. These lesions can present at any location such as cheek, ear lobe on the head, and neck. In our case, a 42‑year‑old female was presented with a pink‑brown colored nodular lesion opening at the upper lip region. The differential diagnosis includes trichofolliculoma and dilated pore of Winer. Trichofolliculomas contain many seconder hair follicles Figure 2: A central cavity with keratin in the dermis which is continuous radiating from the wall of the primary follicle with outer with the surface epithelium (H and E, ×40) and inner root sheaths in a well‑formed stroma which are absent in PSA.
    [Show full text]
  • The Tamilnadu Dr. M.G.R. Medical University Chennai, Tamil Nadu
    CLINICO-PATHOLOGICAL STUDY OF SKIN SURFACE EPIDERMAL AND APPENDAGEAL TUMOURS Dissertation Submitted in partial fulfillment of university regulations for M.D. DEGREE IN DERMATOLOGY, VENEREOLOGY AND LEPROSY BRANCH XII – A THE TAMILNADU DR. M.G.R. MEDICAL UNIVERSITY CHENNAI, TAMIL NADU SEPTEMBER 2006 CERTIFICATE This is to certify that this Dissertation entitled “CLINICO-PATHOLOGICAL STUDY OF SKIN SURFACE EPIDERMAL AND APPENDAGEAL TUMOURS” is a bonafide work done by DR.G.BALAJI, Postgraduate student of Department of Dermatology, Leprosy and Institute of STD, Madras Medical College and Government General Hospital, Chennai – 3 for the award of Degree of M.D.( Dermatology, Venereology and Leprosy ) Branch XII – A during the academic year of 2003-2006. This work has not previously formed in the basis for the award of any degree or diploma. Prof. Dr. B. Parveen, MD., DD., Professor & Head, Dept. of Dermatology and Leprosy, Madras Medical College & Govt. General Hospital, Chennai – 3. Prof. Dr. Kalavathy Ponniraivan, MD., The Dean Madras Medical College & Govt. General Hospital, Chennai – 3. SPECIAL ACKNOWLEDGEMENT I sincerely thank Prof. Dr. Kalavathy Ponniraivan, MD., Dean, Madras Medical College & Govt. General Hospital, Chennai – 3, for granting me permission to use the resources of this institution for my study. ACKNOWLEDGEMENT I sincerely thank Prof. B.Parveen MD.,DD, Professor and Head of Department of Dermatology for her invaluable guidance and encouragement for the successful completion of this study. I express my heart felt gratitude to Dr.N.Gomathy MD.,DD, former Head of department of Dermatology who was instrumental in the initiation of this project, giving constant guidance throughout my work.
    [Show full text]
  • Pdf 344.65 K
    Differential Diagnosis of Basal Cell Carcinoma and Benign Tumors of Hair Follicles Using CD34 RESEARCH COMMUNICATION Differential Diagnosis of Basal Cell Carcinoma and Benign Tumors of Cutaneous Appendages Originating from Hair Follicles by Using CD34 Demet Sengul1, Ilker Sengul2*, Muzeyyen Hesna Astarci3, Huseyin Ustun3, Gamze Mocan4 Abstract Background and Aims: Differential diagnosis of the group of benign trichoblastomas, trichofolliculomas, trichoadenomas and trichoepitheliomas, and basal cell carcinomas (BCCs) is troublesome for the clinician as well as the pathologist, especially when only small biopsy specimens are available. Here we investigated whether CD34 expression might be of assistance. Methods: Thirty benign tumors of cutaneous appendages originating from hair follicles (BTCOHF) and 30 BCCs were retrieved from our archives and immunohistochemically stained. CD 34 expression was graded from [0] to [2+] and compared among the groups and subgroups. Results: There was no significant difference between the degree of expression between [0] and [1+] and [0] and [2+] for each group. However, [1+] and [2+] immunopositivity of BTCOHFs was significantly stronger than in BCCs (p= 0.014). Conclusions: CD34 may contribute to differential diagnosis of skin lesions. Keywords: Basal cell cancer - hair follicle lesions - CD 34 immunohistochemistry Asian Pacific J Cancer Prev, 11, 1615-1619 Introduction in 1958. TAs occur as a nodular lesion usually on the face and buttocks (Rahbari et al., 1977, Swaroop et al., 2008) Ackerman et al classified benign tumors of cutaneous and have a variant of verrucous TA mimicing seboreic appendages originating from hair follicle (BTCOHF)’s keratosis. using eight textbooks of dermatopathology in 2001 as Trichoepithelioma (TE) is a benign skin tumor with germ tumors of hair follicle and hamartomas, infindubular follicular differentiation determined in the classification and isthmic tumors, tumors of external layer, tumors of WHO as the synonym of TB (Cotton, 1991).
    [Show full text]
  • What Are Basal and Squamous Cell Skin Cancers?
    cancer.org | 1.800.227.2345 About Basal and Squamous Cell Skin Cancer Overview If you have been diagnosed with basal or squamous cell skin cancer or are worried about it, you likely have a lot of questions. Learning some basics is a good place to start. ● What Are Basal and Squamous Cell Skin Cancers? Research and Statistics See the latest estimates for new cases of basal and squamous cell skin cancer and deaths in the US and what research is currently being done. ● Key Statistics for Basal and Squamous Cell Skin Cancers ● What’s New in Basal and Squamous Cell Skin Cancer Research? What Are Basal and Squamous Cell Skin Cancers? Basal and squamous cell skin cancers are the most common types of skin cancer. They start in the top layer of skin (the epidermis), and are often related to sun exposure. 1 ____________________________________________________________________________________American Cancer Society cancer.org | 1.800.227.2345 Cancer starts when cells in the body begin to grow out of control. Cells in nearly any part of the body can become cancer cells. To learn more about cancer and how it starts and spreads, see What Is Cancer?1 Where do skin cancers start? Most skin cancers start in the top layer of skin, called the epidermis. There are 3 main types of cells in this layer: ● Squamous cells: These are flat cells in the upper (outer) part of the epidermis, which are constantly shed as new ones form. When these cells grow out of control, they can develop into squamous cell skin cancer (also called squamous cell carcinoma).
    [Show full text]
  • Cutaneous Horn: a Potentially Malignant Entity
    Letter to the editor Cutaneous horn: a potentially malignant entity Cutaneous horn: a potentially malignant entity N. F. Fernandes, S. Sinha, W. C. Lambert, and R. A. Schwartz S UMMARY A cutaneous horn is a conical, dense, hyperkeratotic protrusion that often appears similar to the horn of an animal. It is a morphologic designation referring to an unusually cohesive keratinized material, not a true pathologic diagnosis. Cutaneous horns occur in association with, or as a re- sponse to, a wide variety of underlying benign, pre-malignant, and malignant cutaneous diseases. The most important common concern is distinguishing a hyperkeratotic actinic keratosis from a cutaneous squamous cell carcinoma. Keratoacanthoma is another cause, as illustrated herein as a projective cutaneous tumor with a fingernail-like appearance. The treatment of choice for cuta- neous horns is shave excision with subsequent histopathologic evaluation to rule out underlying malignancy and to guide potential further therapy. KEYIntroduction with the characterization of cutaneous horns as a WORDS medical disorder in the late eighteenth century (2). A cutaneous horn is a conical, dense hyperkeratotic cutaneous protrusion that often resembles the horn of an Epidemiology and etiology horn, cornu animal. The earliest documented case of cutaneous cutaneum, horn, or cornu cutaneum, was that of an elderly Welsh Cutaneous horns are nodules composed of hyperkerato- woman in London who was displayed commercially compact keratin that project above the surface of sis, actinic as an anomaly of nature in 1588 (1). There were the skin. They differ from animal horns by the keratosis, several other accounts of cutaneous horns in the absence of a central bone.
    [Show full text]
  • Rippled-Pattern Sebaceoma: a Report of a Lesion on the Back with a Review of the Literature
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by University of Fukui Repository Rippled-pattern sebaceoma: A report of a lesion on the back with a review of the literature Takahiro Kiyohara, M.D., Masanobu Kumakiri, M.D., Hiroaki Kuwahara, M.D., Atsuko Saitoh, M.D., and Shinichi Ansai, M.D. Department of Dermatology (T.K., M.K.), University of Fukui, Fukui; Division of Plastic Surgery (H.K.), Obihiro-Kousei General Hospital, Obihiro: Sapporo Institute for Dermatopathology (S.A.), Sapporo, Japan Address correspondence and reprint requests to: Takahiro Kiyohara, M.D. Department of Dermatology, University of Fukui 23-3 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan Tel: +81 776 61 3111 Fax: +81 776 61 8112 e-mail: kiyo @ fmsrsa.fukui-med.ac.jp Abstract A 68-year-old Japanese man presented with a tumor that had been present for 5 to 6 years on the right back. Physical examination revealed a dome-shaped, 12x13-mm, dark red tumor. The tumor was excised with a 2 to 3-mm margin. The patient has remained free of disease during 77-months of follow-up. Microscopic examination revealed a bulb-like tumor in the dermis, contiguous with the overlying epidermis. It was composed of small, monomorphous, cigar-shaped basaloid cells in linear, parallel rows, resembling the palisading of nuclei of Verocay bodies, and presenting a rippled-pattern. There were scattered cells showing sebaceous differentiation with vacuolated cytoplasm and scalloped nuclei. There were tiny, duct-like spaces. The tumor revealed characteristics of rippled-pattern sebaceoma.
    [Show full text]