The Potential Effects of Dietary Flavones on Diabetic Nephropathy; a Review of Mechanisms
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Identification of Compounds That Rescue Otic and Myelination
RESEARCH ARTICLE Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant Elvira Diamantopoulou1†, Sarah Baxendale1†, Antonio de la Vega de Leo´ n2, Anzar Asad1, Celia J Holdsworth1, Leila Abbas1, Valerie J Gillet2, Giselle R Wiggin3, Tanya T Whitfield1* 1Bateson Centre and Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom; 2Information School, University of Sheffield, Sheffield, United Kingdom; 3Sosei Heptares, Cambridge, United Kingdom Abstract Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in myelination of the peripheral nervous system. In the zebrafish, mutation of adgrg6 also results in defects in the inner ear: otic tissue fails to down-regulate versican gene expression and morphogenesis is disrupted. We have designed a whole-animal screen that tests for rescue of both up- and down-regulated gene expression in mutant embryos, together with analysis of weak and strong alleles. From a screen of 3120 structurally diverse compounds, we have identified 68 that reduce versican b expression in the adgrg6 mutant ear, 41 of which also restore myelin basic protein gene expression in Schwann cells of mutant embryos. Nineteen compounds unable to rescue a strong adgrg6 allele provide candidates for molecules that may interact directly with the Adgrg6 receptor. Our pipeline provides a powerful approach for identifying compounds that modulate GPCR activity, with potential impact for future drug design. DOI: https://doi.org/10.7554/eLife.44889.001 *For correspondence: [email protected] †These authors contributed Introduction equally to this work Adgrg6 (Gpr126) is an adhesion (B2) class G protein-coupled receptor (aGPCR) with conserved roles in myelination of the vertebrate peripheral nervous system (PNS) (reviewed in Langenhan et al., Competing interest: See 2016; Patra et al., 2014). -
GRAS Notice (GRN) No. 719, Orange Pomace
GRAS Notice (GRN) No. 719 https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/default.htm SAFETY EVALUATION DOSSIER SUPPORTING A GENERALLY RECOGNIZED AS SAFE (GRAS) CONCLUSION FOR ORANGE POMACE SUBMITTED BY: PepsiCo, Inc. 700 Anderson Hill Road Purchase, NY 10577 SUBMITTED TO: U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition Office of Food Additive Safety HFS-200 5100 Paint Branch Parkway College Park, MD 20740-3835 CONTACT FOR TECHNICAL OR OTHER INFORMATION: Andrey Nikiforov, Ph.D. Toxicology Regulatory Services, Inc. 154 Hansen Road, Suite 201 Charlottesville, VA 22911 July 3, 2017 Table of Contents Part 1. SIGNED STATEMENTS AND CERTIFICATION ...........................................................1 A. Name and Address of Notifier .............................................................................................1 B. Name of GRAS Substance ...................................................................................................1 C. Intended Use and Consumer Exposure ................................................................................1 D. Basis for GRAS Conclusion ................................................................................................2 E. Availability of Information ..................................................................................................3 Part 2. IDENTITY, METHOD OF MANUFACTURE, SPECIFICATIONS, AND PHYSICAL OR TECHNICAL EFFECT.................................................................................................4 -
Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals
antioxidants Review Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals Da-Young Lee, Moon-Young Song and Eun-Hee Kim * College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam 13488, Korea; [email protected] (D.-Y.L.); [email protected] (M.-Y.S.) * Correspondence: [email protected]; Tel.: +82-31-881-7179 Abstract: Colorectal cancer still has a high incidence and mortality rate, according to a report from the American Cancer Society. Colorectal cancer has a high prevalence in patients with inflammatory bowel disease. Oxidative stress, including reactive oxygen species (ROS) and lipid peroxidation, has been known to cause inflammatory diseases and malignant disorders. In particular, the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-related protein 1 (KEAP1) pathway is well known to protect cells from oxidative stress and inflammation. Nrf2 was first found in the homolog of the hematopoietic transcription factor p45 NF-E2, and the transcription factor Nrf2 is a member of the Cap ‘N’ Collar family. KEAP1 is well known as a negative regulator that rapidly degrades Nrf2 through the proteasome system. A range of evidence has shown that consumption of phytochemicals has a preventive or inhibitory effect on cancer progression or proliferation, depending on the stage of colorectal cancer. Therefore, the discovery of phytochemicals regulating the Nrf2/KEAP1 axis and Citation: Lee, D.-Y.; Song, M.-Y.; verification of their efficacy have attracted scientific attention. In this review, we summarize the role Kim, E.-H. Role of Oxidative Stress of oxidative stress and the Nrf2/KEAP1 signaling pathway in colorectal cancer, and the possible and Nrf2/KEAP1 Signaling in utility of phytochemicals with respect to the regulation of the Nrf2/KEAP1 axis in colorectal cancer. -
Expression and Functional Analysis of the Nobiletin Biosynthesis-Related
www.nature.com/scientificreports OPEN Expression and functional analysis of the nobiletin biosynthesis‑related gene CitOMT in citrus fruit Mao Seoka1,4, Gang Ma1,2,4, Lancui Zhang2, Masaki Yahata1,2, Kazuki Yamawaki1,2, Toshiyuki Kan3 & Masaya Kato1,2* Nobiletin, a polymethoxy favone (PMF), is specifc to citrus and has been reported to exhibit important health-supporting properties. Nobiletin has six methoxy groups at the 3′,4′,5,6,7,8-positions, which are catalyzed by O-methyltransferases (OMTs). To date, researches on OMTs in citrus fruit are still limited. In the present study, a novel OMT gene (CitOMT) was isolated from two citrus varieties Satsuma mandarin (Citrus unshiu Marc.) and Ponkan mandarin (Citrus reticulata Blanco), and its function was characterized in vitro. The results showed that the expression of CitOMT in the favedo of Ponkan mandarin was much higher than that of Satsuma mandarin during maturation, which was consistent with the higher accumulation of nobiletin in Ponkan mandarin. In addition, functional analysis showed that the recombinant protein of CitOMT had methylation activity to transfer a methyl group to 3′-hydroxy group of favones in vitro. Because methylation at the 3′-position of favones is vital for the nobiletin biosynthesis, CitOMT may be a key gene responsible for nobiletin biosynthesis in citrus fruit. The results presented in this study will provide new strategies to enhance nobiletin accumulation and improve the nutritional qualities of citrus fruit. Flavonoids are a group of secondary metabolites that include more than 10,000 kinds of derivatives1. According to their structure, favonoids are divided into several subgroups, including favanones, favones, favonols, favanols, isofavones, and anthocyanidins2. -
Selecting Bioactive Phenolic Compounds As Potential Agents to Inhibit Proliferation and VEGF Expression in Human Ovarian Cancer Cells
1444 ONCOLOGY LETTERS 9: 1444-1450, 2015 Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells ZHIPING HE1,2, BO LI2, GARY O. RANKIN3, YON ROJANASAKUL4 and YI CHARLIE CHEN1,2 1Key Laboratory for Quality Improvement of Agricultural Products of Zhejiang Province, College of Agriculure and Food Science, Zhejiang A & F University, Lin'an, Zhejiang 311300, P.R. China; 2College of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416; 3Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701; 4Department of Basic Pharmaceutical Science, West Virginia University, Morgantown, WV 26506, USA Received April 14, 2014; Accepted December 2, 2014 DOI: 10.3892/ol.2014.2818 Abstract. Ovarian cancer is a disease that continues to Introduction cause mortality in female individuals worldwide. Ovarian cancer is challenging to treat due to emerging resistance to Phenolic compounds, a large family of natural compounds chemotherapy, therefore, the identification of effective novel with phenolic hydroxyl groups, are present in plants, fruits, chemotherapeutic agents is important. Polyphenols have vegetables and teas, and have been demonstrated to exhibit anti- demonstrated potential in reducing the risk of developing cancer properties. The potential application of these phenolic numerous types of cancer, as well reducing the risk of cancer compounds in the development of therapeutic agents for cancer progression, due to their ability to reduce cell viability and treatment has gained increasing importance in the previous vascular endothelial growth factor (VEGF) expression. In the decade and research in this field is currently expanding (1‑3). -
48003 Hughes Et Al 2017 Accepted Version.Pdf
ResearchOnline@JCU This is the Accepted Version of a paper published in the Journal: Critical Reviews in Food Science and Nutrition Hughes, Samuel D., Ketheesan, Natkunam, and Haleagrahara, Nagaraja (2017) The therapeutic potential of plant flavonoids on rheumatoid arthritis. Critical Reviews in Food Science and Nutrition, 57 (17). pp. 3601-3613. http://dx.doi.org/10.1080/10408398.2016.1246413 © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ Critical Reviews in Food Science and Nutrition ISSN: 1040-8398 (Print) 1549-7852 (Online) Journal homepage: http://www.tandfonline.com/loi/bfsn20 The Therapeutic Potential of Plant Flavonoids on Rheumatoid Arthritis Samuel D. Hughes, Natkunam Ketheesan & Nagaraja Haleagrahara To cite this article: Samuel D. Hughes, Natkunam Ketheesan & Nagaraja Haleagrahara (2016): The Therapeutic Potential of Plant Flavonoids on Rheumatoid Arthritis, Critical Reviews in Food Science and Nutrition, DOI: 10.1080/10408398.2016.1246413 To link to this article: http://dx.doi.org/10.1080/10408398.2016.1246413 Accepted author version posted online: 22 Nov 2016. Submit your article to this journal Article views: 122 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=bfsn20 Download by: [JAMES COOK UNIVERSITY] Date: 23 March 2017, At: 16:37 ACCEPTED MANUSCRIPT The Therapeutic Potential of Plant Flavonoids on Rheumatoid Arthritis Samuel D. Hughes1, Natkunam Ketheesan2 & Nagaraja Haleagrahara3,* 1,2,3Biomedicine, College of Public Health, Medical & Veterinary Sciences, and 2, 3Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, Townsville, Australia *Address correspondence to: Nagaraja Haleagrahara, Biomedicine, College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, Australia. -
Identification of the Anti-COVID-19 Mechanism of Action of Han-Shi Blocking Lung Using Network Pharmacology- Integrated Molecular Docking
Yuan et al Tropical Journal of Pharmaceutical Research June 2021; 20 (6): 1241-1249 ISSN: 1596-5996 (print); 1596-9827 (electronic) © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. Available online at http://www.tjpr.org http://dx.doi.org/10.4314/tjpr.v20i6.21 Original Research Article Identification of the anti-COVID-19 mechanism of action of Han-Shi Blocking Lung using network pharmacology- integrated molecular docking Chong Yuan1, Fei Wang1, Peng-Yu Chen1, Zong-Chao Hong1, Yan-Fang Yang1,2, He-Zhen Wu1,2* 1Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, 2Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, Wuhan 430061, China *For correspondence: Email: [email protected], [email protected]; Tel: +86-13667237629, +86-13545341663 Sent for review: 30 June 2020 Revised accepted: 16 May 2021 Abstract Purpose: To investigate the bio-active components and the potential mechanism of the prescription remedy, Han-Shi blocking lung, with network pharmacology with a view to expanding its application. Methods: Chemical components were first collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Pharmmapper database and GeneCards were used to predict the targets related to active components and COVID-19. Using DAVIDE and KOBAS 3.0 databases, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were enriched. A “components-targets-pathways” (C-T-P) network was conducted by Cytoscape 3.7.1 software. With the aid of Discovery Studio 2016 software, bio-active components were selected to dock with SARS-COV-2 3CL and ACE2. -
Identification of Compounds That Rescue Otic And
bioRxiv preprint doi: https://doi.org/10.1101/520056; this version posted January 16, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 Identification of compounds that rescue otic and myelination defects in the 2 zebrafish adgrg6 (gpr126) mutant 3 4 Elvira Diamantopoulou1,*, Sarah Baxendale1,*, Antonio de la Vega de León2, Anzar Asad1, 5 Celia J. Holdsworth1, Leila Abbas1, Valerie J. Gillet2, Giselle R. Wiggin3 and Tanya T. 6 Whitfield1# 7 8 1Bateson Centre and Department of Biomedical Science, University of Sheffield, Sheffield, 9 S10 2TN, UK 10 2Information School, University of Sheffield, Sheffield, S1 4DP, UK 11 3Sosei Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK 12 13 *These authors contributed equally 14 15 #Corresponding author: 16 Tanya T. Whitfield: [email protected] 17 ORCID iD: 0000-0003-1575-1504 18 19 Key words: zebrafish, aGPCR, Adgrg6, Gpr126, phenotypic screening, chemoinformatics, 20 versican, myelination, inner ear, lateral line, Schwann cells 21 22 1 bioRxiv preprint doi: https://doi.org/10.1101/520056; this version posted January 16, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 23 ABSTRACT 24 Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in 25 myelination of the peripheral nervous system. -
Dietary Apigenin and Naringenin Protect Against Colon
DIETARY APIGENIN AND NARINGENIN PROTECT AGAINST COLON CARCINOGENESIS BY LOWERING HIGH MULTIPLICITY ABERRANT CRYPT FOCI AND ENHANCING APOPTOSIS IN AZOXYMETHANE-TREATED RATS A Thesis by TETY LEONARDI Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE May 2005 Major Subject: Nutrition DIETARY APIGENIN AND NARINGENIN PROTECT AGAINST COLON CARCINOGENESIS BY LOWERING HIGH MULTIPLICITY ABERRANT CRYPT FOCI AND ENHANCING APOPTOSIS IN AZOXYMETHANE-TREATED RATS A Thesis by TETY LEONARDI Submitted to Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: Nancy D. Turner Joanne R. Lupton (Co-Chair of Committee) (Co-Chair of Committee) Robert S. Chapkin Naisyin Wang (Member) (Member) Nancy D. Turner Gary R. Acuff (Chair of Faculty of Nutrition) (Head of Department) May 2005 Major Subject: Nutrition iii ABSTRACT Dietary Apigenin and Naringenin Protect Against Colon Carcinogenesis by Lowering High Multiplicity Aberrant Crypt Foci and Enhancing Apoptosis in Azoxymethane-Treated Rats. (May 2005) Tety Leonardi, B.S., Texas A&M University Co-Chairs of Advisory Committee: Dr. Nancy D. Turner Dr. Joanne R. Lupton Colon cancer is the third most common cancer in the United States. However, evidence indicates that a proper diet abundant in fruits and vegetables may be protective against colon cancer development. Bioactive compounds in fruits and vegetables, such as flavonoids and limonoids, have been shown to possess anti-proliferative and anti- tumorigenic effects in various in vitro and in vivo models of cancer. -
Nobiletin Delays Aging and Enhances Stress Resistance of Caenorhabditis Elegans
International Journal of Molecular Sciences Article Nobiletin Delays Aging and Enhances Stress Resistance of Caenorhabditis elegans Xueyan Yang 1, Hong Wang 1,2,* , Tong Li 3, Ling Chen 2, Bisheng Zheng 1,4 and Rui Hai Liu 3,* 1 Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China; [email protected] (X.Y.); [email protected] (B.Z.) 2 Ministry of Education Engineering Research Centre of Starch & Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510641, China; [email protected] 3 Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853, USA; [email protected] 4 Guangdong ERA Food & Life Health Research Institute, Guangzhou 510670, China * Correspondence: [email protected] (H.W.); [email protected] (R.H.L.) Received: 9 December 2019; Accepted: 29 December 2019; Published: 4 January 2020 Abstract: Nobiletin (NOB), one of polymethoxyflavone existing in citrus fruits, has been reported to exhibit a multitude of biological properties, including anti-inflammation, anti-oxidation, anti-atherosclerosis, neuroprotection, and anti-tumor activity. However, little is known about the anti-aging effect of NOB. The objective of this study was to determine the effects of NOB on lifespan, stress resistance, and its associated gene expression. Using Caenorhabditis elegans, an in vivo nematode model, we found that NOB remarkably extended the lifespan; slowed aging-related functional declines; and increased the resistance against various stressors, including heat shock and ultraviolet radiation. -
( 12 ) United States Patent
US010722444B2 (12 ) United States Patent ( 10 ) Patent No.: US 10,722,444 B2 Gousse et al. (45 ) Date of Patent : Jul. 28 , 2020 (54 ) STABLE HYDROGEL COMPOSITIONS 4,605,691 A 8/1986 Balazs et al . 4,636,524 A 1/1987 Balazs et al . INCLUDING ADDITIVES 4,642,117 A 2/1987 Nguyen et al. 4,657,553 A 4/1987 Taylor (71 ) Applicant: Allergan Industrie , SAS , Pringy (FR ) 4,713,448 A 12/1987 Balazs et al . 4,716,154 A 12/1987 Malson et al. ( 72 ) 4,772,419 A 9/1988 Malson et al. Inventors: Cécile Gousse , Dingy St. Clair ( FR ) ; 4,803,075 A 2/1989 Wallace et al . Sébastien Pierre, Annecy ( FR ) ; Pierre 4,886,787 A 12/1989 De Belder et al . F. Lebreton , Annecy ( FR ) 4,896,787 A 1/1990 Delamour et al. 5,009,013 A 4/1991 Wiklund ( 73 ) Assignee : Allergan Industrie , SAS , Pringy (FR ) 5,087,446 A 2/1992 Suzuki et al. 5,091,171 A 2/1992 Yu et al. 5,143,724 A 9/1992 Leshchiner ( * ) Notice : Subject to any disclaimer , the term of this 5,246,698 A 9/1993 Leshchiner et al . patent is extended or adjusted under 35 5,314,874 A 5/1994 Miyata et al . U.S.C. 154 (b ) by 0 days. 5,328,955 A 7/1994 Rhee et al . 5,356,883 A 10/1994 Kuo et al . (21 ) Appl . No.: 15 /514,329 5,399,351 A 3/1995 Leshchiner et al . 5,428,024 A 6/1995 Chu et al . -
Citrus Flavonoids As Promising Phytochemicals Targeting Diabetes and Related Complications: a Systematic Review of in Vitro and in Vivo Studies
nutrients Review Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies Gopalsamy Rajiv Gandhi 1,2,3, Alan Bruno Silva Vasconcelos 4 , Ding-Tao Wu 5 , Hua-Bin Li 6 , Poovathumkal James Antony 7, Hang Li 1,2 , Fang Geng 8 , Ricardo Queiroz Gurgel 3, Narendra Narain 9 and Ren-You Gan 1,2,8,* 1 Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences (CAAS), Chengdu 600103, China; [email protected] (G.R.G.); [email protected] (H.L.) 2 Chengdu National Agricultural Science and Technology Center, Chengdu 600103, China 3 Postgraduate Program of Health Sciences (PPGCS), Federal University of Sergipe (UFS), Prof. João Cardoso Nascimento Campus, Aracaju, Sergipe 49060-108, Brazil; [email protected] 4 Postgraduate Program of Physiological Sciences (PROCFIS), Federal University of Sergipe (UFS), Campus São Cristóvão, São Cristóvão, Sergipe 49100-000, Brazil; [email protected] 5 Institute of Food Processing and Safety, College of Food Science, Sichuan Agricultural University, Ya’an 625014, China; [email protected] 6 Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; [email protected] 7 Department of Microbiology, St. Xavier’s College, Kathmandu 44600, Nepal; [email protected] 8 Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs),