SUPPLEMENTAL FIGURE LEGENDS

Supplemental Figure 1. H226 cells express ΔNp63α and functional p53. (A)

Western blot of total cell extracts from H226 cells as well as myc tagged p63 isoforms using a pan-p63 antibody and an antibody that specifically recognizes the α-isoforms of p63. (B) FACS analysis of cell cycle profile following staining with propidium iodide.

H226 cells were treated with 10uM Nutlin-3, a non-genotoxic activator of p53, for 48 hours. (C) Sulforhodamine B (SRB) assay of cell proliferation following 5 days of knockdown of ΔNp63α and/or p53. (D) Cell cycle profile following 5 days of knockdown of ΔNp63α and/or p53. (E) Apoptotic index of cells following 5 days of knockdown of

ΔNp63α. Treatment with 375 µM of the antimetabolite 5-fluorouracil (5FU) for 48 hours serves as a positive control. Cells were stained with annexin V and propidium iodide and analyzed by flow cytometry. Histograms represent the percentage of cells positive for annexin V staining.

Supplemental Figure 2. ΔNp63α does not repress 14-3-3σ, GADD45A, NOXA or

PUMA in H226 cells. Validation of microarray results by quantitative RT-PCR analysis of additional Class I genes following 12 hours of 10 µM Nutlin-3 treatment, 48 hours of

ΔNp63α knockdown, or combination treatment.

Supplemental Figure 3. Gene-specific repression by ΔNp63α in diverse cell types.

Q-RT-PCR analysis of selected Class I, II, and III target genes following 48 hours of

ΔNp63α knockdown in (A) HaCaT cells (immortalized keratinocytes), (B) SCC-13 cells

(oral HNSCC), (C) Cal-27 (tongue HNSCC).

Supplemental Figure 4. Gene expression classes are conserved following administration of additional p53 activating stimuli. (A) Western blot and (B) Q-RT- PCR analysis of selected Class I, II, and III target genes following 12 hours of p53 activation by the antimetabolite 5FU in H226 cells.

Supplemental Figure 5. A schematic representation of p53 and ΔNp63α target gene loci. A linear scale model of selected Class I, II, and III gene loci indicating the locations of the p53/p63 response elements (RE) (REs indicated by asterisk, if more than one RE is present, the RE used for chromatin immunoprecipitation analysis is indicated in red), transcription start sites and exon/intron structure. Coding exons are indicated in black, UTRs in white. Sequence information for the p53/63 RE binding site(s) are indicated to the right of the schematic for each locus.

Supplemental Figure 6. Presentation of Figure 2 according to % input for all IPs.

ChIP assays of the ZHX2 locus were performed using cell extracts from H226 cells. (A)

Extracts from cells before (black lines) and 48 h after (blue lines) ΔNp63α knockdown were utilized. (B) Extracts from control cells (black lines) and DMAP1 constitutive knockdown cells (green lines) were utilized. Antibodies specific for p63, Ser5- phosphorylated RNAPII, DMAP1, RUVBL2 and H2A.Z were used. ChIP-enriched DNA was quantified by real-time PCR. The position of each PCR amplicon is indicated on a linear scale model of the locus. The position of the p53/p63 response element is indicated by a red asterisk. The gray band represents the transcribed region of the locus.

Supplemental Figure 7. p53 and ΔNp63α binding profiles are conserved following administration of additional p53 activating stimuli. ChIP assays were performed with whole cell extracts from control cells (white bars) or following 12 h of 375mM 5FU treatment (black bars). Antibodies specific for p53 and p63 were used. ChIP-enriched DNA was quantified by real-time PCR for the p53/p63 response elements of each indicated gene. See Supp. Figure 5 for gene maps and amplicon locations.

Supplemental Figure 8. Confirmation of SRCAP complex knockdown effect on

Class I and III gene expression. (A) Composition of SRCAP, Tip60, and related complexes. Data combined from reviews by (Jin et al. 2005; Huen et al. 2010; Billon and Côté 2012). (B) Quantitative RT-PCR analysis of gene expression in H226 cells stably expressing a second shRNA against SRCAP subunits SRCAP, ACTR6, ACTL6A,

RUVBL1, RUVBL2, DMAP1, VPS72 and YEATS4 and non-SRCAP subunits KAT5,

EP400, INO80 and SMARCA2.

Supplemental Figure 9. Validation of SRCAP/Tip60 complex member knockdowns.

Quantitative RT-PCR validation of SRCAP, ACTR6, ACTL6A, DMAP1, RUVBL1,

RUVBL2, VPS72, YEATS4, KAT5, EP400, INO80 and SMARCA2 constitutive knockdown.

Supplemental Figure 10. Oncomine analysis of ZHX2 expression. Screenshots from

Oncomine (www.oncomine.org) indicating decreased ZHX2 expression in numerous patient (A) squamous cell carcinoma and (B) other carcinoma samples (dark blue bars) as compared to normal lung tissue (light blue bars). Multiple datasets (Hou PLoS One

2010, Estilo BMC Cancer 2009 and Finak Nat Med 2008) were utilized.

Supplemental Figure 11. Presentation of Figure 4 according to % input for all IPs.

ChIP assays of the ZHX2 locus were performed using cell extracts from H226 cells. (A)

Extracts from cells before (black lines) and 48 h after (blue lines) ΔNp63α knockdown were utilized. (B) Extracts from control cells (black lines) and DMAP1 constitutive knockdown cells (green lines) were utilized. Antibodies specific for p63, Ser5- phosphorylated RNAPII, DMAP1, RUVBL2 and H2A.Z were used. ChIP-enriched DNA was quantified by real-time PCR. The position of each PCR amplicon is indicated on a linear scale model of the locus. The position of the p53/p63 response element is indicated by a red asterisk. The gray band represents the transcribed region of the locus.

Supplemental Figure 12. Loss of SRCAP and histone variant H2A.Z occupancy upon ΔNp63α knockdown at additional Class III genes. ChIP assays of DMAP1 and

RUVBL2 binding to the enhancer regions of the Class III genes NTN4, SAMD9L and

IGFBP3 and ChIP assays of H2A.Z binding to the promoter regions of those genes.

ChIP was performed with whole cell extracts from control cells (white bars) or following

48 hours of ΔNp63α knockdown (black bars). ChIP-enriched DNA was quantified by real-time PCR.

Supplemental Figure 13. Validation of H2A.Z knockdown. (A) Western blot and (B) quantitative RT-PCR validating H2A.Z knockdown following 5 days of treatment with

2ug/mL doxycycline.

Supplemental Figure 14. Rescue of ΔNp63α knockdown phenotype by SAMD9L and IGFBP3 knockdown. Time course of cell proliferation using a second shRNA against SAMD9L or IGFBP3. 1x106 cells were seeded at day 0. shp63 cells were pretreated with doxycycline for 5 days prior to seeding to induce p63 knockdown.

Supplemental Figure 15. Oncomine analysis of SAMD9L expression. Screenshots from Oncomine (www.oncomine.org) indicating decreased SAMD9L expression in numerous patient (A) lung SCC and (B) other lung cancer samples (dark blue bars) as compared to normal lung tissue (light blue bars). Multiple datasets (Hou PLoS One

2010 and Garber PNAS 2001) utilized.

SUPPLEMENTAL TABLES

Supplemental Table 1: Microarray results following Nutlin-3 treatment and

ΔNp63α knockdown, sorted by fold change.

Supplemental Table 2: Microarray results following Nutlin-3 treatment and

ΔNp63α knockdown, sorted by p value.

Supplemental Table 3: shRNA vector and sequence information.

Supplemental Table 4: Antibody information.

Supplemental Table 5: Oligonucleotide sequences for quantitative RT-PCR analysis of gene expression and ChIP Q-PCR analysis.

Gallant-Behm198069_Supp.Fig1 A B 100

H226 extractmyc-ΔNp63myc-Δαmyc-TAp63Np63γmyc-TAp63α H226γ extractmyc-ΔNp63myc-Δαmyc-TAp63Np63γmyc-TAp63α γ G2/M 170 75 130 S 110 50 G1

ΔNp63α % cells 70 25 Debris 55 40 WB: Pan p63 Ab α-specific p63 Ab Nutlin-3 +

C 0.5 D 100 E 80 )

510 G2/M 75 60 S 0.25 50 40 G1 % cells 25 20

SRB Assay (A Debris Annexin-V positive (%)

H226 shp53 shp53 + + shp63 OFF ON OFF shp63 OFF shp63 OFF ON OFF ON 5FU + shp63 ON Gallant-Behm198069_Supp.Fig2

14-3-3σ GADD45A 3 2 2 1 1

NOXA PUMA 4 4 3 3 2 2 Relative mRNA expression Relative mRNA 1 1

shp63 + None Nutlin-3 shp63 Nutlin-3 Gallant-Behm198069_Supp.Fig3

HaCaT 3 shp63 shp63OFF ON ΔNp63α

2 Nucleolin

1

0

SCC-13 14 shp63 shp63OFF ON 10 ΔNp63α 4 Nucleolin 3 2 1 0 Relative mRNA expression Relative mRNA

Cal-27 3 shp63 shp63OFF ON ΔNp63α 2 Nucleolin

1

0 4 N p21 BAX T GJB4 ZHX2 N MDM2 PLAC8 IGFBP3 FAM49A SAMD9L

Class I: Class II: Class III: p53 induced p53 induced, ΔNp63α repressed ΔNp63α repressed

shp63 OFF shp63 ON Gallant-Behm198069_Supp.Fig4

A B Class I p21 BAX MDM2 5 3 8 4 6 3 2 shp63: + + 4 2 1 5FU: + + 1 2

ΔNp63α Class II GJB4 FAM49A PLAC8 p53 2 2 2

p21 1 1 1 Nucleolin Relative mRNA expression Relative mRNA Class III ZHX2 NTN4 SAMD9L 2 2 2

1 1 1

Control 5FU Gallant-Behm198069_Supp.Fig5

p21 AGACTGGGCA/TGTCTGGGCA = 2000bp (CDKN1A) * * GAAGAAGACT/GGGCATGTCT p53R2 TGACATGCCC/AGGCATGTCT (RRM2B) * MDM2 AGTTAAGTCC/TGACTTGTCT ** GGTCAAGTTC/AGACACGTTC PUMA CTGCAAGTCC/TGACTTGTCC (BBC3) * DR5 GGGCATGTCC/GGGCAAGACG (TNFRSF10B) * GADD45A GAACATGTCT/AAGCATGCTG * PCNA GAACAAGTCC/GGGCATATGT * FAS GGACAAGCCC/TGACAAGCCA

Class I * MASPIN GAACATGTTG/G/AGGCCTTTTG p53 activated (SERPINB5) * 14-3-3σ AGCATTAGCCC/AGACATGTCC (SFN) * APAF1 * AGACATGTCT/GGAGACCCTAGGA/CGACAAGCCC NOXA GAGCGTGTCC/GGGCAGGTCG (PMAIP1) * FDXR GGGCAGGAGC/GGGCTTGCCC * TCACAAGTTA/G/AGACAAGCCT BAX GGGCAGGCCC/GGGCTTGTCG * *

TLR3 AGGCATGCAC/CAACATGCCC * TMEM27 AGACATGTTG/TGGCTTGAAA * PLAC8 TTACAAGTAA/GAACTTGTTT * GCTCATGCTC/C/CATCTAGCCT GJB4 AGACAAGCCC/AA/GGACAAGGAA Class II * * TCACATGCAG/C/CTCCTTGGCC p53 activated, GGT6

Δ Np63 α repressed * BLNK TGACAAGTGA/GAACTTGTCT TCACATGATT/ATGTAG/AAACATGAAA **

EDN2 CTGCAAGCCC/GGGCATGCCC * NTN4 TTCCTAGTAA/GGACTTGTTG * ST14 TTTCATGACC/AGACAAGTCC * ZHX2 GGCCTTGGAA/TTTAAAAAATCAC/TATCAAGCCT * SAMD9L AAGCAAGCAG/ACTCATGACT

Class III * TP53INP2 AGACAAGGCC/AGGG/CCCCAAGCAT

Δ Np63 α repressed * ACTA2 AACCATGCCT/GCATCTGCCC * IGFBP3 AAACAAGCCA/C/CAACATGCTT * * GGGCAAGACC/TGCCAAGCCT Gallant-Behm198069_Supp.Fig6

A B C IP: p53 Class I Class II Class III 8 0.96 1.28

6 0.64

4 0.64

(% input) 0.32 2 Relative p53 binding

σ p21 FAS DR5 BAX TLR3 ST14 p53R2MDM2PUMA PCNA NOXAFDXR GJB4GGT6BLNK EDN2NTN4 ZHX2 14-3-3APAF1 PLAC8 ACTA2IGFBP3 MASPIN TMEM27 SAMD9L GADD45A TP53INP2 D IP: ΔNp63α E F 0.8 0.8 2

1.6 0.6 0.6 α binding 1.2 0.4 0.4

Δ Np63 0.8 (% input) 0.2 0.2 0.4 Relative σ p21 FAS DR5 BAX TLR3 ST14 p53R2MDM2PUMA PCNA NOXAFDXR GJB4GGT6BLNK EDN2NTN4 ZHX2 14-3-3APAF1 PLAC8 ACTA2IGFBP3 MASPIN TMEM27 SAMD9L GADD45A TP53INP2 p53 activated genes ΔNp63α repressed genes Basal Nutlin-3 shp63 Nutlin-3 + shp63 Gallant-Behm198069_Supp.Fig7

IP: p53 Class I Class II Class III 16 20 100 12 15 75 8 10 50 25 4 5 Relative p53 binding

p21 DR5 TLR3 GJB4 EDN2 NTN4 ST14 ZHX2 p53R2 MDM2 PUMA PLAC8 GGT6 TMEM27 SAMD9L GADD45A IP: ΔNp63α 40 40 100 30 30 75 20 20 Δ Np63 α binding 50 25 10 10 Relative

p21 DR5 TLR3 GJB4 EDN2 NTN4 ST14 ZHX2 p53R2 MDM2 PUMA PLAC8 GGT6 TMEM27 SAMD9L GADD45A Control 5FU Gallant-Behm198069_Supp.Fig8 A BRD8 SRCAP C20Orf20 (MrgBP) Tip60 ACTR6 DMAP1 H2A.Z Actin EP400 (p400) ACTL6A VPS72 EPC1/2 SRCAP YEATS4 MORF4L2 (MrgX) Znf-HIT1 RUVBL1 ING3 TRRAP RUVBL2 KAT5 (Tip60) MEAF6 MORF4L1 (Mrg15) ACTL6B ARID Amida ARID1A/B ACTR5/6 PBRM1 GLI3 SMARCA2/4 INO80 SMARCB1 MCRS1 INO8D/E SMARCC1/2 NFRKB les6 SMARCD1/2/3 UCHL5 BAF SMARCE1 YY1 Ino80

B 4 ZHX2 10 SAMD9L 8 3 6 2 4 1 2

0 0

6 NTN4 IGFBP3 6

4 4

2 2

0 0 #2 #2 #2 #2 Control TS4 #2 Control TS4 #2 shKAT5 #2 shKAT5 #2 shACTR6 #2 shVPS72 #2 shEP400shINO80 #2 #2 shACTR6 #2 shVPS72 #2 shEP400shINO80 #2 #2 shSRCAPshACTL6shRUVBL1AshRUVBL2 shDMAP1#2 #2 shYE #2 A shSRCAPshACTL6shRUVBL1AshRUVBL2 shDMAP1#2 #2 shYE #2 A

SRCAP subunits non-SRCAP SRCAP subunits non-SRCAP Relative mRNA expression Relative mRNA subunits subunits

p21 6

4

2

0 #2 #2 Control TS4 #2 shKAT5 #2 shACTR6 #2 shVPS72 #2 shEP400shINO80 #2 #2 shSRCAPshACTL6shRUVBL1AshRUVBL2 shDMAP1#2 #2 shYE #2 A

SRCAP subunits non-SRCAP subunits Gallant-Behm198069_Supp.Fig9

SRCAP ACTR6 ACTL6A RUVBL1 1.5 1.5 1.5 1.5

1 1 1 1

0.5 0.5 0.5 0.5

0 0 0 0

Control Control Control Control

shACTR6shACTR6 #1 #2 shSRCAPshSRCAP #1 #2 shACTL6AshACTL6A #1 #2 shRUVBL1shRUVBL1 #1 #2 RUVBL2 DMAP1 VPS72 YEATS4 1.5 1.5 1.5 1.5

1 1 1 1

0.5 0.5 0.5 0.5

0 0 0 0

Control Control Control Control

Relative mRNA expression Relative mRNA shVPS72shVPS72 #1 #2 shRUVBL2shRUVBL2 #1 #2 shDMAP1shDMAP1 #1 #2 shYEATS4shYEATS4 #1 #2 KAT5 EP400 INO80 1.5 1.5 1.5

1 1 1

0.5 0.5 0.5

0 0 0

Control Control Control shKAT5shKAT5 #1 #2 shEP400shEP400 #1 #2 shINO80shINO80 #1 #2 Gallant-Behm198069_Supp.Fig10

A Squamous cell carcinoma Hou: Lung SCC Estilo: Head-Neck SCC Lung SCC Lung (n=65) Tongue (n=26) Tongue SCC (n=31) (n=27) 2.0 3.0

-1.0 -0.5

log2 median centered intensity Fold change -1.523 Fold change -1.360 p=6.92E-8 p=0.002

B Other Carcinomas Hou: Large cell lung carcinoma Finak: Invasive breast carcinoma Large CLC Breast Invasive breast carcinoma Lung (n=65) (n=19) (n=6) (n=53) 2.0 0.5

-1.5 -2.0

log2 median centered intensity Fold change -1.829 Fold change -1.380 p=2.54E-6 p=4.38E-8 Gallant-Behm198069_Supp.Fig11 A ZHX2 B ZHX2 0.46 0.68 ΔNp63α 0.23 0.34

0.3 0.65 RNAPII 0.15 0.325 (S5P)

0.062 0.068 DMAP1 0.031 0.034

0.7 0.045 ChIP signal (% input) ChIP signal (% input) ChIP RUVBL2 0.35 0.0225

2 0.8 H2A.Z 1 0.4

* * = 1Kb = 100Kb = 1Kb = 100Kb

shp63 OFF shp63 ON Control shDMAP1 Gallant-Behm198069_Supp.Fig12

DMAP1 (enhancer) 100 80 60 40 20

RUVBL2 (enhancer) 100 80 60 40

Relative binding 20

H2A.Z (promoter)

100 80 60 40 20

NTN4 SAMD9L IGFBP3 shp63 OFF shp63 ON Gallant-Behm198069_Supp.Fig13

A B H2A.Z shH2A.Z OFF ON 1

H2A.Z

0.5 Actin expression Relative mRNA Relative mRNA

shH2A.Z OFF ON Gallant-Behm198069_Supp.Fig14

shp63 ON shp63 OFF 108 108

107 107 Cell number

106 106 0 2 4 6 8 10 0 2 4 6 8 10 Days Control shSAMD9L#2 shIGFBP3#2 Gallant-Behm198069_Supp.Fig15

A Lung SCC Hou: Lung SCC Garber: Lung SCC Lung SCC Lung (n=65) Lung (n=5) Lung SCC (n=13) (n=27) 2.5 2.5

-2.5 -1.0

log2 median centered intensity Fold change -3.321 Fold change -2.048 p=1.23E-11 p=0.002

B Other Lung Carcinomas

Hou: Large cell lung carcinoma Garber: Small cell lung carcinoma Large CLC Lung (n=65) Lung (n=5) SCLC (n=4) (n=19) 2.5 2.0

-3.0 0

log2 median centered intensity Fold change -5.424 Fold change -2.134 p=2.88E-10 p=8.25E-4 Supplemental Table 1: Microarray results sorted by fold change

* Gene symbols in bold indicate genes that are downregulated in primary lung SCCs as compared to normal lung tissue (The Cancer Genome Atlas, https://tcga-data.nci.nih.gov/tcga/ ; Agilent G4502A_07 z-score ≤-0.5, frequency ≥20%)

Increased by Nutlin-3 (1.5 fold, p<0.05) Increased by shp63 (1.5 fold, p<0.05) Fold change p-value Fold change p-value Fold change p-value Fold change p-value Gene Gene RefSeq (Basal vs (Basal vs (Basal vs (Basal vs RefSeq (Basal vs (Basal vs (Basal vs (Basal vs symbol symbol Nutlin-3) Nutlin-3) shp63) shp63) shp63) shp63) Nutlin-3) Nutlin-3) ABCA12 NM_173076 6.54111 3.04036E-06 -1.6659 0.000525859 TMPRSS11E NM_014058 8.60843 2.97654E-05 1.1414 0.26441 WDR63 NM_145172 5.29644 3.89077E-05 -1.291 0.0390339 ANKRD22 NM_144590 7.64084 0.000778596 -1.77573 0.0603585 GDF15 NM_004864 5.01123 9.73733E-06 1.28514 0.0121404 SLC28A3 NM_022127 6.2034 0.000166084 -1.23369 0.190956 PLTP NM_006227 4.1896 0.000517195 -1.44309 0.059059 CENPT NM_025082 6.05155 2.7078E-06 1.14706 0.0425124 DSG3 NM_001944 3.92494 6.05255E-05 -1.74508 0.00198529 MMP13 NM_002427 4.64335 0.00403798 -1.07852 0.784639 EDA2R NM_021783 3.91235 2.22471E-07 -1.08866 0.0109384 HCP5 NM_006674 4.09159 0.000138244 1.47997 0.0163491 ABCC2 NM_000392 3.88651 8.60926E-05 1.14408 0.18466 CEACAM6 NM_002483 4.05916 0.00506308 1.3804 0.268605 FRMPD2 NM_001018071 3.8179 0.000294293 -1.16548 0.248386 PEG10 NM_001040152 4.01868 0.000133417 -1.38342 0.0280132 LRDD NM_018494 3.81619 7.67249E-05 -1.00858 0.920621 SLC6A14 NM_007231 3.42823 0.00046478 -1.0413 0.747517 STARD5 NM_181900 3.81292 1.97357E-05 1.24623 0.0182978 TRIM55 NM_033058 2.81563 0.000282598 1.34018 0.0279119 ACER2 NM_001010887 3.80954 0.000165199 -1.18906 0.151153 PPP1R3C NM_005398 2.78247 0.00359548 -1.05409 0.768222 CDH10 NM_006727 3.74252 0.000194156 -1.46161 0.0194915 MACC1 NM_182762 2.6926 0.000862686 -1.05858 0.634131 PRDM1 NM_001198 3.7006 3.77891E-05 1.22181 0.0382735 ZHX2 NM_014943 2.68533 9.97191E-06 -1.01576 0.682662 CLCA2 NM_006536 3.69194 1.17354E-05 -1.34446 0.00377641 ADCY9 NM_001116 2.54315 0.00020458 -1.01641 0.832329 DQX1 NM_133637 3.67582 0.000447675 1.03008 0.821097 SAMD9L NM_152703 2.53886 0.000369548 1.03829 0.676533 ZNF385A NM_015481 3.60289 0.000266815 -1.55518 0.0140092 EDN2 NM_001956 2.53842 0.00154119 -1.16679 0.27205 LCE1B NM_178349 3.50606 0.000115393 -1.00759 0.932381 ANXA9 NM_003568 2.40084 0.000910221 -1.06261 0.573697 GLS2 NM_013267 3.437 0.00125359 -1.71344 0.0240176 STEAP4 NM_024636 2.39584 0.00289177 -1.58994 0.0260776 FAM198B NM_001128424 3.43421 3.49012E-06 -1.20297 0.00563003 TP53INP2 NM_021202 2.39453 0.00030049 -1.24631 0.0414688 NUPR1 NM_001042483 3.4275 1.40445E-05 1.17604 0.0283876 ADAM21 NM_003813 2.3937 0.00135221 1.21758 0.147208 RGS2 NM_002923 3.4142 0.00156672 -3.51989 0.00142763 CAPN13 NM_144575 2.37875 0.000164315 -1.0187 0.784105 CCDC60 NM_178499 3.35876 2.80331E-05 -1.12138 0.112675 CXCL11 NM_005409 2.27938 0.000946235 1.19562 0.131095 PLAT NM_000930 3.28378 6.69448E-05 1.10956 0.206903 GJB4 NM_153212 2.25408 1.03243E-06 2.04299 1.72792E-06 C6orf138 NM_001013732 3.25572 0.000480356 1.16262 0.254529 IGFBP3 NM_001013398 2.22728 0.000406959 -1.04227 0.604173 CEACAM1 NM_001712 3.19415 0.000190608 1.38245 0.0212126 TM4SF1 NM_014220 2.16285 0.000282541 1.40837 0.00609963 CYFIP2 NM_001037332 3.14283 9.67053E-06 -1.73274 0.00017708 GBP2 NM_004120 2.15025 0.00419416 1.00642 0.963194 SESN1 NM_014454 3.13977 1.74955E-05 -1.55507 0.000740178 FLG NM_002016 2.1356 0.00475068 1.06986 0.639937 CYP4F3 NM_000896 3.06999 0.000536236 -1.38536 0.0423273 PPARGC1A NM_013261 2.09507 0.00117884 -1.53026 0.00900875 CDKN1A NM_078467 3.0493 0.000074776 1.16957 0.0784663 ELF3 NM_001114309 2.09139 0.003761 -1.52168 0.0262056 AREG NM_001657 3.04529 0.00106163 -1.21804 0.207648 S100P NM_005980 2.07605 0.00210024 1.11169 0.36276 MUC19 AK093065 3.03749 0.000159229 1.00695 0.935529 P2RY6 NM_176796 2.04166 0.00119327 -1.23973 0.0685616 CMBL NM_138809 2.92479 0.000310597 -1.48963 0.0123972 ST14 NM_021978 2.02069 0.000033025 -1.05481 0.19377 NM_001098479/ C13orf31 NM_153218 2.89743 4.87894E-06 -1.00324 0.92427 HLA-F NM_018950 2.00945 0.00034727 1.00212 0.974194 GAL3ST4 NM_024637 2.89111 0.000308504 1.08108 0.439865 FGFBP1 NM_005130 2.00572 0.00465258 -1.26872 0.122598 ANKRA2 NM_023039 2.82915 2.05742E-06 -1.25507 0.000837047 IL8 NM_000584 2.00133 0.00156014 1.09715 0.363817 SPATA18 NM_145263 2.7807 7.02885E-06 -1.20002 0.00565653 LHFPL2 NM_005779 1.99994 0.00093629 1.16789 0.121358 CEL NM_001807 2.77683 0.000256173 1.11516 0.261639 AQP3 NM_004925 1.99907 0.00343193 -1.03671 0.762895 TP53I3 NM_004881 2.76081 0.000198984 -1.16901 0.115224 ATP2B4 NM_001001396 1.99655 0.000196113 -1.12492 0.0896063 PXT1 NM_152990 2.73998 0.000734549 -1.03468 0.768113 SLC25A36 NM_001104647 1.98075 0.000859248 1.15783 0.127169 BTG2 NM_006763 2.72228 0.000019824 -1.14734 0.032608 RUNX2 NM_001024630 1.96106 0.000228309 -1.01208 0.833204 BCL6 NM_001706 2.70686 0.000032873 1.4769 0.00128531 CRIP2 NM_001312 1.95994 0.00066973 1.28953 0.0225326 RAD51C NM_058216 2.69459 0.00147886 -2.55021 0.00183561 CPEB4 NM_030627 1.9589 0.000151776 1.47467 0.00127632 C12orf5 NM_020375 2.66085 0.000026464 -1.25755 0.00702272 NTN4 NM_021229 1.94997 0.000222146 -1.13262 0.0771249 TRIM22 NM_006074 2.6214 0.000167895 1.06031 0.454143 TMTC2 NM_152588 1.94349 0.000573021 1.01713 0.811799 RRM2B NM_015713 2.58747 1.98737E-05 1.0174 0.693387 CSPG4 NM_001897 1.94102 0.00234765 -1.38906 0.0271365 TEX9 NM_198524 2.58676 0.000131535 -1.19813 0.0509612 HLA-B NM_005514 1.93051 0.000220385 1.17106 0.0379418 XG NM_001141919 2.55639 6.25312E-06 -1.16774 0.00668795 C2orf54 NM_001085437 1.92973 0.000346517 -1.38991 0.00476585 SERPINE2 NM_001136529 2.53757 0.00135013 -2.01406 0.00392062 MXRA5 NM_015419 1.92289 0.000234478 1.07598 0.233617 FDXR NM_024417 2.5297 2.25759E-05 1.00278 0.949314 SULT2B1 NM_004605 1.92062 0.000397221 1.07208 0.308344 LGALS9C NM_001040078 2.52638 5.28355E-06 1.34233 0.000491204 LIPH NM_139248 1.91469 0.00493033 -1.12105 0.378868 TP53INP1 NM_033285 2.51711 3.11096E-05 1.02777 0.569202 PLAUR NM_002659 1.89832 0.000807815 1.16342 0.0980235 POLH NM_006502 2.51475 6.23214E-05 -1.51855 0.0013644 SLC22A18 NM_002555 1.8943 0.00132345 1.08646 0.357692 ZNF750 NM_024702 2.51145 0.000106824 -1.10122 0.184739 C15orf41 NM_032499 1.88488 5.34273E-05 1.11181 0.0381917 ABCA1 NM_005502 2.50979 5.25104E-05 1.08316 0.187428 MALL NM_005434 1.86003 0.000409902 1.1483 0.0729944 INPP5D NM_001017915 2.49904 2.6588E-06 -1.2906 0.000419376 SLC2A3 NM_006931 1.85744 0.00484574 -1.46873 0.0247808 MDM2 NM_002392 2.48701 0.00129666 -1.34287 0.0598702 MUC1 NM_001018016 1.84987 0.00219652 -1.33514 0.0302873 FBXW7 NM_033632 2.48314 0.000253063 -1.34145 0.0166194 RAPH1 NM_213589 1.84952 7.76805E-05 -1.07021 0.141478 MARCH8 NM_001002265 2.48073 3.00749E-05 -1.10127 0.0890706 SCGB3A1 NM_052863 1.84277 0.000151349 -1.01377 0.769953 ZBED2 NM_024508 2.4763 4.99851E-05 -1.35536 0.00341823 DDX60L NM_001012967 1.84242 0.00279022 -1.07979 0.456072 FOS NM_005252 2.47124 0.000255319 -1.03946 0.628087 CASZ1 NM_001079843 1.84044 0.00328786 -1.27643 0.065944 CSF1 NM_000757 2.46418 7.07422E-05 -1.01427 0.802985 SCNN1A NM_001038 1.83359 0.00283191 1.02403 0.810611 HSD17B7 NM_016371 2.46002 1.93863E-05 -1.09381 0.0791587 VLDLR NM_003383 1.83102 0.00256947 1.24551 0.0715926 CELF2 NM_001025077 2.43653 0.000269799 -1.00415 0.95787 GPR110 NM_153840 1.82683 0.00549731 1.08321 0.509556 CCDC29 ENST00000340460 2.4346 7.04559E-06 -1.27001 0.00123595 FAM43A NM_153690 1.8248 0.000447583 1.17145 0.0493173 PRKX NM_005044 2.42253 3.08165E-05 -1.43584 0.00102465 ATP1B1 NM_001677 1.82199 0.000792341 -1.43109 0.00544896 FAS NM_000043 2.42234 1.23621E-07 -1.23611 3.69392E-05 NPAS2 NM_002518 1.81813 0.00158427 1.10346 0.277267 APOBEC3C NM_014508 2.42161 2.48485E-05 -1.30136 0.00276233 SLC16A2 NM_006517 1.80058 2.34246E-05 -1.08987 0.0304655 GHR NM_000163 2.40668 0.00164533 1.00046 0.997062 CITED2 NM_006079 1.79848 0.000760023 1.05807 0.424054 CABYR NM_012189 2.40388 0.000311852 -1.07818 0.374485 DAGLA NM_006133 1.78509 0.00234373 -1.09065 0.36136 SULF2 NM_018837 2.3994 2.48944E-05 -1.25794 0.00442335 TMEM139 NM_153345 1.78501 0.000875825 -1.05017 0.493318 GGT6 NM_001122890 2.3732 1.42617E-05 1.50408 0.000276636 RHOV NM_133639 1.77795 0.000033356 -1.30895 0.000658903 ZMAT3 NM_022470 2.34821 1.48634E-06 -1.00894 0.664692 SLC22A23 NM_015482 1.77169 0.000178064 -1.29056 0.00391258 LGALS9B NM_001042685 2.34728 1.23188E-05 1.33683 0.000856018 MFSD7 NM_032219 1.77099 0.00179142 -1.20415 0.0742916 PLEKHG1 NM_001029884 2.33285 0.000903078 -1.08993 0.419528 VTCN1 NM_024626 1.76591 0.00373419 -1.92355 0.0022207 MIR221 NR_029635 2.33182 0.000189346 -1.02456 0.724107 INSL4 NM_002195 1.76328 0.00112358 -1.15813 0.0966914 D32129/ CASP1 NM_033292 2.32519 0.00102881 -2.42816 0.000849068 HLA-A NM_002116 1.76194 0.000100025 1.11661 0.0389098 HSDL2 NM_032303 2.32311 4.75884E-05 -1.63889 0.000389255 GALNT5 NM_014568 1.76071 0.00449316 1.62809 0.00766896 ZNF654 NM_018293 2.31597 0.000475544 -1.19907 0.0869764 GAB2 NM_080491 1.75708 0.00163092 -1.29574 0.0253415 CES2 NM_003869 2.31091 0.000108956 -1.13008 0.0905562 OSBPL7 NM_145798 1.75636 0.00127299 1.04488 0.562914 CASP10 NM_032977 2.30972 0.00103879 -1.10779 0.35606 KRTAP2-1 NM_001123387 1.75505 6.28425E-05 -1.18248 0.00647337 MARCH3 NM_178450 2.29434 4.41331E-05 -1.34077 0.00251156 STK17B NM_004226 1.75418 0.00476792 -1.1688 0.190581 EFNB1 NM_004429 2.28608 0.00024827 -1.51034 0.00354418 UPK2 NM_006760 1.75007 0.000381336 1.09396 0.150876 GPR87 NM_023915 2.28451 0.000529798 -1.53001 0.00639841 FER1L6 NM_001039112 1.74735 0.00246941 1.05246 0.568139 SRGAP3 NM_014850 2.27808 2.23452E-05 -1.47618 0.000427106 DCLK2 NM_001040260 1.74204 0.0017173 -1.85546 0.00114115 CSNK1G1 NM_022048 2.26261 1.97709E-05 -1.23264 0.00389668 ABHD4 NM_022060 1.74097 0.000109524 1.24466 0.00389225 TNFRSF10D NM_003840 2.25792 0.000167578 -1.21476 0.0311733 TJP3 NM_014428 1.73843 0.00279729 -1.34206 0.0251526 ARAP1 NM_015242 2.24885 0.000250939 -1.18913 0.0582418 PPL NM_002705 1.73809 0.00360664 -1.12747 0.254709 RPS27L NM_015920 2.24665 2.96912E-05 1.16705 0.0157151 BTBD3 NM_014962 1.73799 0.000456457 -1.38003 0.00354877 DNAJC18 NM_152686 2.24605 0.000203327 1.08275 0.271248 EDNRA NM_001957 1.73777 0.000245828 -1.00452 0.924451 CROT NM_001143935 2.24266 0.000103964 -1.21007 0.0220857 BLNK NM_013314 1.72965 0.000140051 1.75968 0.000123994 KIAA0247 NM_014734 2.21875 0.00007459 1.09526 0.128533 TLR3 NM_003265 1.72596 0.000401498 1.8135 0.000286227 BLOC1S2 NM_001001342 2.21835 1.00611E-07 -1.41037 2.8897E-06 SYNGR3 NM_004209 1.70615 0.00413257 -1.41889 0.0181019 KITLG NM_000899 2.21253 0.000314988 -2.0692 0.000443957 CYP1A1 NM_000499 1.70598 0.00257877 -1.2661 0.0415335 DOCK8 NM_203447 2.20027 3.72673E-05 -1.02413 0.578973 B3GALT4 NM_003782 1.70208 0.0013665 -1.05634 0.4595 BAX NR_027882 2.19809 5.80684E-05 -1.00116 0.980316 GOT1 NM_002079 1.69706 0.0005283 -1.02569 0.651555 MICALCL NM_032867 2.19389 0.000792651 -1.75481 0.00281284 B3GNT2 NM_006577 1.69575 0.00390924 -1.07026 0.484279 XPC NM_004628 2.19291 6.90867E-05 -1.28493 0.00550662 CD68 NM_001251 1.69517 0.00195878 1.20774 0.0613547 ANK1 NM_020476 2.1718 3.74084E-06 1.14183 0.00370253 FAM49A NM_030797 1.6947 0.00109056 1.80695 0.000701956 TNFRSF10C NM_003841 2.16703 5.76306E-05 1.06604 0.213561 KRTAP2-4 NM_033184 1.69191 6.69355E-05 -1.10169 0.0338978 FBXO22 NM_147188 2.16597 7.81936E-05 -1.35218 0.00296006 HLA-J NR_024240 1.68923 0.000562682 1.08436 0.197407 ZNF114 NM_153608 2.16482 0.000235126 -1.55769 0.00199605 KCNK15 NM_022358 1.68844 0.000214728 -1.26499 0.00455287 PLCL2 NM_015184 2.15972 0.000413907 -1.09284 0.280244 CITED4 NM_133467 1.68703 0.00155875 1.05137 0.503618 ISCU NM_014301 2.15796 0.000389418 -1.20253 0.0578584 CLDN4 NM_001305 1.67907 0.00189556 1.05251 0.512162 FBN2 NM_001999 2.15256 4.75089E-05 -1.66964 0.000232297 HLA-G NM_002127 1.67773 0.000977226 1.09977 0.186597 TMEM68 NM_152417 2.15029 0.000104066 -1.42226 0.0021009 SNORA80B NR_028374 1.67401 0.000727957 -1.24863 0.0157263 ANTXR2 NM_058172 2.14968 0.00108088 1.52533 0.00962883 LCE1D NM_178352 1.66956 0.00183405 1.0582 0.463341 LASS6 NM_203463 2.14037 6.89574E-05 -1.4066 0.00156381 WIPI1 NM_017983 1.66852 0.000545496 1.00158 0.976724 PLAC8 NM_016619 2.13599 0.00111466 1.65088 0.00523024 KRT13 NM_153490 1.66627 0.000231278 -1.06968 0.172902 TNFRSF10B NM_003842 2.13481 2.41893E-06 -1.10805 0.00583219 TMEM45B NM_138788 1.66569 0.000442206 1.16943 0.0309922 MAPKBP1 NM_014994 2.12991 0.00098527 1.02662 0.778901 ABCD1 NM_000033 1.6638 0.00180094 1.08104 0.32203 SERPINB7 NM_003784 2.12398 0.000193802 -1.29575 0.0106663 SPINT1 NM_181642 1.66174 0.00287795 -1.26495 0.0394941 NYNRIN NM_025081 2.11833 6.95679E-07 1.14169 0.000668411 FNDC3A NM_001079673 1.65997 0.000435029 1.0635 0.264151 GLDC NM_000170 2.0888 0.00166307 -1.07549 0.498072 MIR23B NR_029664 1.65637 0.00409136 -1.20276 0.0964644 ZNF79 NM_007135 2.08812 7.98454E-05 -1.03341 0.503347 UQCRFS1 NM_006003 1.65441 0.00513787 -1.08764 0.406346 SESN2 NM_031459 2.08496 0.000641775 -1.02503 0.76136 C1orf116 NM_023938 1.65218 0.000472481 1.46547 0.00134935 PRKD2 NM_016457 2.07834 0.000196851 -1.0018 0.975931 PLAC8 NM_016619 1.65088 0.00523024 2.13599 0.00111466 ZNF658 NM_033160 2.07725 0.000107415 -1.267 0.00780898 TMEM27 NM_020665 1.64851 3.01761E-05 1.82907 1.42417E-05 SLC6A4 NM_001045 2.07686 0.000231563 1.24464 0.019783 IDH2 NM_002168 1.64807 0.00104434 -1.29466 0.011686 RALGDS NM_006266 2.0723 0.000218011 -1.28304 0.0120513 SLC25A23 NM_024103 1.64323 0.000904242 -1.14627 0.0720167 RNASE7 NM_032572 2.06712 0.00164686 -2.60625 0.000570133 CD55 NM_001114752 1.64232 3.99001E-06 -1.00837 0.588385 GJB4 NM_153212 2.04299 1.72792E-06 2.25408 1.03243E-06 MAP2K1 NM_002755 1.64151 0.00342497 -1.28977 0.033296 TAF3 NM_031923 2.03834 0.000205502 -1.39048 0.00390216 ACTA1 NM_001100 1.63407 0.00134306 -1.42853 0.00442758 RHOD NM_014578 2.03735 4.31801E-05 1.08721 0.0868309 LOC441204 AK056484 1.63171 0.000385725 1.04643 0.364891 HSD17B7P2 NR_003086 2.02619 0.00141797 -1.04082 0.679215 MGC16121 NR_024607 1.63103 0.00273046 -1.20282 0.0673826 RBL2 NM_005611 2.00394 0.000176275 -1.22879 0.016274 BAMBI NM_012342 1.63028 0.00273145 -1.35733 0.014549 PTAFR NM_001164721 1.99888 5.96072E-05 1.45219 0.000673081 HLA-C NM_002117 1.62478 4.97169E-05 1.07991 0.0424805 PLK3 NM_004073 1.98819 2.75059E-05 1.01088 0.751524 ANTXR1 NM_032208 1.62411 0.00202959 -1.07426 0.350745 TRIAP1 NM_016399 1.98195 0.000566926 -1.22283 0.0426393 TNXA NR_001284 1.62303 0.00145085 1.06241 0.384218 TNFRSF10A NM_003844 1.96825 0.000130118 -1.3375 0.00335289 C9orf150 NM_203403 1.6181 0.000776298 1.03132 0.587312 NCKAP5 NM_207363 1.9656 0.00125399 -1.42811 0.0128577 KLF12 NM_007249 1.61582 0.00179814 -1.35778 0.00928659 TRPV6 NM_018646 1.96112 0.000140057 1.07072 0.221226 GPSM3 NM_022107 1.61034 0.00260675 -1.23968 0.0394114 TTYH3 NM_025250 1.94659 0.000230054 1.0106 0.851913 LDB3 NM_007078 1.61008 0.00237164 -1.38852 0.00914614 CCNG1 NM_004060 1.94246 5.38519E-06 -1.22271 0.000602154 FYB NM_001465 1.60967 3.37414E-05 1.44448 0.000093723 F2R NM_001992 1.93888 0.00153301 -1.14168 0.19834 MTMR11 NM_001145862 1.60643 0.000354544 -1.2183 0.00937739 XDH NM_000379 1.9385 0.000253347 -2.00128 0.000210721 TMEM38A NM_024074 1.60565 0.000325758 -1.42852 0.000975723 SLC44A5 NM_152697 1.92537 4.24339E-05 1.01314 0.720067 MALT1 NM_006785 1.60502 0.00121002 -1.12164 0.117804 DUOX1 NM_017434 1.92355 0.000401713 -1.14426 0.0880252 RASSF5 NM_182663 1.60477 0.00219677 1.17284 0.0778192 ZNF37A NM_001007094 1.91839 0.000416857 -1.33205 0.00894985 FBXL19-AS1 NR_024348 1.60324 0.00193398 1.01352 0.84692 MR1 NM_001531 1.90948 0.000557762 1.15173 0.0938792 HLA-H NR_001434 1.60263 0.000239195 1.07276 0.1373 VSIG1 NM_001170553 1.90645 0.000120308 -1.30643 0.00355795 ABCC1 NM_004996 1.59927 0.000424623 1.06943 0.199167 ERAP2 NM_022350 1.9061 0.000057334 -1.15408 0.0164674 KRTAP5-2 NM_001004325 1.59637 0.000102335 -1.81588 3.90823E-05 NRP2 NM_201266 1.90526 5.58604E-06 1.00937 0.666054 SLC44A1 NM_080546 1.59432 0.0011779 -1.05853 0.371343 NINJ1 NM_004148 1.90133 9.29897E-05 1.0293 0.516003 CCND3 NM_001760 1.59229 0.00190145 -1.27088 0.0200096 ZNF563 NM_145276 1.89819 0.00026773 -1.00913 0.872053 RNASE1 NM_198232 1.5908 0.00112226 1.16348 0.0527182 PSTPIP2 NM_024430 1.89537 0.000147917 -1.74982 0.000249767 H1F0 NM_005318 1.58939 0.0013528 1.03874 0.549686 CD82 NM_002231 1.89499 0.000038595 1.20566 0.00443553 RAG1AP1 NM_018845 1.58754 0.00295862 1.00809 0.915765 TSPAN5 NM_005723 1.89495 0.000533915 -1.34686 0.00916645 ASS1 NM_000050 1.58665 0.000356165 1.28164 0.00377759 MAST4 NM_001164664 1.8926 0.000416368 -1.09801 0.188492 DUSP8 NM_004420 1.58527 0.000410734 -1.30119 0.00345217 RETSAT NM_017750 1.88902 0.000520008 1.06255 0.385559 HLA-E NM_005516 1.58499 0.00199469 1.09381 0.234807 MCC NM_001085377 1.88013 0.000205366 -1.37041 0.00295433 SIGLEC5 NM_003830 1.58477 0.000121496 1.31514 0.000918854 LRP1 NM_002332 1.8733 5.64337E-05 -1.14514 0.0178594 MUC21 NM_001010909 1.58193 0.00122703 -1.00131 0.982508 PPM1D NM_003620 1.86771 0.000171568 -1.01508 0.761743 BRP44L NM_016098 1.57761 0.00314194 -1.02039 0.792341 TMEM131 NM_015348 1.86529 5.80666E-05 -1.11981 0.0317482 C2orf18 NM_017877 1.5762 0.000088593 -1.01684 0.587937 AEN NM_022767 1.86486 0.000336477 -1.26825 0.012145 SLC6A20 NM_020208 1.57555 1.83225E-05 1.00113 0.955539 CYP4F11 NM_021187 1.85215 0.000852015 1.01461 0.842974 ZNF837 NM_001129730 1.57431 0.000399765 -1.08852 0.11088 KRT15 NM_002275 1.85139 0.000248257 1.23322 0.0137202 ACO2 NM_001098 1.57292 0.00177254 1.09037 0.230041 RAP2B NM_002886 1.85105 2.43015E-06 -1.19699 0.000319531 CRB3 NM_139161 1.57199 0.000538111 -1.12434 0.0587908 NADSYN1 NM_018161 1.84498 0.000175695 1.08867 0.135051 SYNPO NM_007286 1.5714 0.000409705 -1.08367 0.125998 JHDM1D NM_030647 1.83407 0.00117028 1.15742 0.117216 OTX2 NM_021728 1.57135 0.00209191 -1.11902 0.15257 FAM83A NM_032899 1.83367 0.000231645 -1.05885 0.301982 ECM1 NM_004425 1.57116 0.0013345 1.09324 0.190343 ALOX5 NM_000698 1.82967 0.000060082 1.35653 0.000871347 TP53TG3 NM_016212 1.56969 0.00142851 -1.0077 0.900316 TMEM27 NM_020665 1.82907 1.42417E-05 1.64851 3.01761E-05 ACP2 NM_001610 1.56629 0.00362694 -1.16958 0.0997723 RFX7 NM_022841 1.81934 4.29851E-05 -1.42304 0.000344347 EFNA1 NM_004428 1.56552 0.00426125 -1.42999 0.00953579 TLR3 NM_003265 1.8135 0.000286227 1.72596 0.000401498 CHST15 NM_015892 1.56486 0.00236069 1.01457 0.835421 C16orf5 NM_013399 1.80735 0.000604446 1.32795 0.00928823 HYAL1 NM_007312 1.56486 0.00132693 -1.25945 0.0146296 CCDC51 NM_024661 1.80709 0.000273288 -1.15472 0.0429846 ERBB3 NM_001982 1.56374 0.0023206 -1.39452 0.00684722 FAM49A NM_030797 1.80695 0.000701956 1.6947 0.00109056 KRTAP1-5 NM_031957 1.56115 0.00355439 -1.34279 0.0152605 ZSCAN4 NM_152677 1.80472 0.000176751 -1.03549 0.471429 CLIC3 NM_004669 1.55864 0.00180755 -1.25871 0.0187764 GNAI1 NM_002069 1.80312 9.69704E-05 -1.40107 0.0008578 NR4A1 NM_002135 1.55241 0.00172179 -1.06061 0.374462 BTBD10 NM_032320 1.7937 2.28907E-05 -1.25473 0.000936428 GIPR NM_000164 1.55096 0.000999379 -1.00076 0.988859 DDB2 NM_000107 1.79205 2.79967E-05 -1.11308 0.0170022 RABL3 NM_173825 1.54955 0.000179298 1.05392 0.18336 ZNF383 NM_152604 1.79039 5.66698E-05 -1.03224 0.383624 SYNPO2L NM_001114133 1.54916 0.00182618 -1.03814 0.563826 DUSP14 NM_007026 1.78756 0.000140562 1.07774 0.13997 CHST6 NM_021615 1.54874 0.000811919 -1.12897 0.0652871 METTL8 NM_024770 1.78378 0.00160095 -1.25462 0.0406447 TPRA1 NM_016372 1.54794 0.000132252 -1.1907 0.00443817 DOCK4 NM_014705 1.77811 0.000532856 1.27874 0.0123392 KLF4 NM_004235 1.54622 0.000494622 1.15977 0.0245599 DFNB31 NM_015404 1.77607 2.35481E-05 1.42063 0.000165028 CLCNKA NM_004070 1.54586 0.00338106 -1.39478 0.00891124 ERI2 NM_001142725 1.77527 6.62147E-05 -1.36016 0.000760398 TP53I11 NM_001076787 1.54337 0.00181858 1.3245 0.00887825 ZNF561 NM_152289 1.7743 0.000412726 -1.3907 0.00338515 TTYH1 NM_020659 1.5429 0.00199514 -1.17708 0.054179 PROM2 NM_001165978 1.77083 0.000115821 1.16666 0.0156089 ALDH3A2 NM_001031806 1.54179 0.000774568 1.29058 0.00560839 ANXA4 NM_001153 1.76955 3.76997E-06 -1.1294 0.00163808 GSTK1 NM_001143679 1.54133 0.0018849 1.00703 0.911799 ANK3 NM_020987 1.76615 3.79644E-05 -1.08366 0.0485788 AGER NM_001136 1.54118 0.000929614 1.01471 0.781754 BLNK NM_013314 1.75968 0.000123994 1.72965 0.000140051 SHISA7 NM_001145176 1.54108 0.00117996 -1.03295 0.569956 MARVELD2 NM_001038603 1.75914 0.00041975 -1.14863 0.0572785 ACTA2 NM_001141945 1.54084 0.00288438 -1.3241 0.0134449 NOTCH1 NM_017617 1.75131 0.000270523 -1.24038 0.00974397 MEIS2 NM_172316 1.539 0.00363072 -1.05357 0.500554 CCNK NM_001099402 1.74843 9.17456E-06 -1.20961 0.000641004 AGVR6190 AY358245 1.53883 0.00118781 -1.16702 0.0419867 KCNG1 NM_002237 1.74368 0.000329332 -1.02558 0.629757 PDZK1IP1 NM_005764 1.53883 0.00565464 -1.23406 0.0575991 VANGL2 NM_020335 1.73963 0.00173701 -1.01348 0.86582 ADAM9 NM_003816 1.53757 0.00236795 -1.12989 0.123443 PARD6G NM_032510 1.7373 6.62173E-05 -2.24863 1.44644E-05 TACC2 NM_206862 1.53422 0.00130991 1.04228 0.480991 DSC3 NM_024423 1.73519 0.000497535 -1.48957 0.00172403 PNPLA2 NM_020376 1.52905 0.00157809 -1.16025 0.0556006 ETV5 NM_004454 1.73512 0.0017493 -1.39372 0.0110103 KIAA0895 NM_001100425 1.52693 0.00510062 -1.33335 0.0193715 SFN NM_006142 1.72884 9.31404E-05 -1.51347 0.000278228 MYOZ3 NM_001122853 1.52672 0.00331612 -1.0419 0.576327 P4HA2 NM_004199 1.72177 0.000127203 -1.09892 0.064059 TMOD1 NM_003275 1.52229 0.0051779 -1.23805 0.0479722 RAB1A NM_004161 1.72043 0.000183093 -1.10386 0.0721618 STAMBPL1 NM_020799 1.52187 0.000198063 -1.14412 0.0138177 TRANK1 NM_014831 1.71384 0.00174138 -1.04775 0.554479 CYB5R1 NM_016243 1.5218 0.003137 -1.1089 0.192615 AK1 NM_000476 1.70929 0.000134531 1.06551 0.163123 CRLF1 NM_004750 1.52165 0.00200572 -1.10657 0.158858 TMEM63B NM_018426 1.70804 0.000202152 -1.04791 0.319267 MAP1B NM_005909 1.51702 0.00541929 -1.41113 0.0106275 STX6 NM_005819 1.70307 0.000217216 -1.33161 0.00235845 KYNU NM_003937 1.51655 0.00289074 1.02188 0.752459 COL17A1 NM_000494 1.70292 0.000137066 -1.12089 0.0370691 ATP1B2 NM_001678 1.51453 0.00127909 1.04485 0.441584 STEAP2 NM_152999 1.70211 0.000402415 -1.26418 0.00862524 TMPRSS13 NM_001077263 1.51449 0.00358104 -1.13265 0.139495 GM2A NM_000405 1.6961 6.74513E-05 1.22981 0.0025479 LBH NM_030915 1.51225 0.00481477 -1.46437 0.00644436 TGFBRAP1 NM_004257 1.69592 8.52713E-05 -1.35998 0.000707774 OGDH NM_002541 1.51119 0.000794162 1.00109 0.981921 TMEM156 NM_024943 1.69486 0.000317118 -1.20312 0.0153403 RILP NM_031430 1.51068 0.00289699 -1.2258 0.032724 FAM84A NM_145175 1.69435 0.000635107 1.13012 0.0878809 ALDH3B2 NM_000695 1.51034 0.00266163 -1.36302 0.00753566 GXYLT1 NM_173601 1.69241 0.00142854 -1.34293 0.0117431 TMEM173 NM_198282 1.50744 0.000735213 1.32487 0.00307191 PORCN NM_022825 1.69226 0.000738922 1.04726 0.459458 TMEM53 NM_024587 1.50713 0.00432165 -1.2582 0.0310092 C9orf169 NM_199001 1.68834 7.53234E-05 1.18763 0.00538678 GRAMD1A NM_020895 1.50684 0.000671639 -1.17011 0.0216003 SYNC NM_030786 1.68821 0.000150149 1.47965 0.000466864 ERRFI1 NM_018948 1.5056 0.00112415 -1.17908 0.0282537 LPAR5 NM_020400 1.68801 9.84076E-06 1.25489 0.000268272 CGN NM_020770 1.50483 0.00445646 -1.25469 0.03266 SLC31A2 NM_001860 1.68577 0.000105538 1.09945 0.0496329 ACSL1 NM_001995 1.50445 0.0035753 -1.08008 0.311515 FITM2 NM_001080472 1.68009 0.000876769 1.0292 0.647046 GGT6 NM_001122890 1.50408 0.000276636 2.3732 1.42617E-05 UNC5B NM_170744 1.6755 0.00147997 -1.09 0.264326 TBC1D19 NM_018317 1.50406 0.00514871 -1.0478 0.55985 MDM4 NM_002393 1.67355 0.000170454 -1.19449 0.00941201 TMEM52 NM_178545 1.50273 0.00195731 -1.07402 0.274606 APAF1 NM_181861 1.67142 0.000194135 -1.01867 0.660947 CYP4B1 NM_001099772 1.50233 0.0051625 -1.22797 0.0488379 KAT2B NM_003884 1.67069 0.00162244 -1.0306 0.679163 TPPP NM_007030 1.50139 0.000611867 -1.15268 0.0267722 SLFN5 NM_144975 1.66842 0.00132615 1.13418 0.120586 MFAP2 NM_002403 1.50053 0.00464735 -1.1223 0.179728 CLN8 NM_018941 1.66291 3.03205E-05 1.07776 0.0364278 PLCH2 NM_014638 1.66252 0.000198237 1.04341 0.336194 TLE4 NM_007005 1.66043 0.00169491 1.15179 0.104968 TRAK1 NM_001042646 1.65903 0.000190847 1.05674 0.223807 LAMB3 NM_001017402 1.65614 0.00171531 -1.31208 0.0158292 PRICKLE2 NM_198859 1.65402 0.000183372 -1.03027 0.473924 ZFYVE1 NM_021260 1.6534 1.45455E-05 1.44346 5.07726E-05 ASB1 NM_001040445 1.64865 0.000792537 -1.46794 0.00216455 BBS7 NM_176824 1.64432 1.42124E-06 -1.30981 1.62625E-05 KIAA1199 NM_018689 1.64305 0.000835801 1.30164 0.00871143 DCP1B NM_152640 1.64049 0.00100226 -1.11377 0.134342 DTX4 NM_015177 1.63641 0.000476815 1.05667 0.307807 ASCC3 NM_006828 1.63502 6.31373E-07 -1.43482 2.16727E-06 TRUB1 NM_139169 1.63369 0.000156731 -1.29277 0.00191616 ZNF195 NM_001130520 1.63257 0.00044718 -1.24244 0.00932506 CSTA NM_005213 1.63235 0.000789424 -1.78323 0.000415477 RABGGTA NM_004581 1.63041 0.000384464 1.04567 0.370762 ZNF219 NM_016423 1.63032 0.000149765 -1.30583 0.00156183 KCTD11 NM_001002914 1.62831 0.00147629 -1.02424 0.721969 DEPDC7 NM_001077242 1.62754 0.000131686 -1.26509 0.00219429 TP53TG1 AB007455 1.62725 0.00101994 -1.08931 0.20679 SCRIB NM_182706 1.62556 0.00149391 -1.04125 0.554214 C1orf88 NM_181643 1.62546 0.00012379 1.2414 0.00280155 RCBTB1 NM_018191 1.62092 7.05828E-05 1.0003 0.992184 CCDC90B NM_021825 1.62007 9.27976E-05 1.21357 0.00314119 KIAA0040 NM_014656 1.61986 9.29281E-05 1.20597 0.00354876 PCLO NM_033026 1.61158 0.00115782 -1.12025 0.119925 LRRC28 NM_144598 1.61108 2.85166E-06 1.05584 0.0123048 SMTN NM_134269 1.61007 0.00108357 1.01942 0.75063 SLAMF7 NM_021181 1.61002 0.000106299 1.1315 0.0165321 KIAA1217 NM_019590 1.60807 0.00122029 1.29514 0.01125 TMTC3 NM_181783 1.60713 8.85995E-07 -1.27405 1.29517E-05 C20orf112 NM_080616 1.60648 0.000230647 1.15905 0.0173471 ZNF337 NM_015655 1.60538 0.000141872 -1.02042 0.576399 PLAU NM_002658 1.60346 0.00139759 -1.06624 0.34437 MED23 NM_004830 1.60003 4.62882E-05 -1.14791 0.00518088 SERINC5 NM_178276 1.59841 0.00015488 -1.01449 0.691664 APOBEC3F NM_145298 1.59716 0.000737716 -1.11918 0.0885048 TRIM3 NM_006458 1.59389 0.000396655 1.0996 0.0898131 MOSPD1 NM_019556 1.59208 0.00030297 -1.15029 0.0242505 SMEK1 NM_032560 1.59167 0.000716615 -1.14001 0.057136 BNC1 NM_001717 1.58989 0.000740777 -1.3144 0.00536639 IP6K2 NM_016291 1.58877 0.000883349 -1.03568 0.53751 F2RL2 NM_004101 1.58801 0.000409563 1.20547 0.0118406 FAM129B NM_022833 1.58725 0.00036873 1.42123 0.00105973 SEMA3B NM_004636 1.58053 0.000773795 1.16392 0.037936 STEAP3 NM_182915 1.58034 8.70281E-05 -1.1672 0.0055448 UNC13B NM_006377 1.57453 0.00033287 -1.11506 0.0516352 LDB1 NM_003893 1.57225 0.000884051 1.01677 0.760211 SMG6 NM_017575 1.57203 0.000069918 -1.12824 0.0105044 ABTB2 NM_145804 1.57134 0.000311141 1.24386 0.00492311 HHAT NM_001170580 1.57052 0.00112038 -1.06583 0.30325 GOLGB1 NM_004487 1.56974 0.000631261 1.08942 0.139073 SLC30A1 NM_021194 1.56871 1.28104E-05 -1.10473 0.00447073 PLCXD2 NM_153268 1.56723 0.000961013 -1.17513 0.0353631 C1orf57 NM_032324 1.56546 7.25697E-05 -1.29214 0.000647368 SEMA3F NM_004186 1.56414 0.000259987 1.13791 0.0244394 FAM27A NR_024060 1.56378 0.00103293 -1.28718 0.00851896 C20orf72 BC016869 1.56212 0.000840601 -1.46012 0.00157265 RGL1 NM_015149 1.56058 0.000436517 1.30081 0.00323167 PANK1 NM_148977 1.56039 0.000610807 1.03621 0.477717 WDR8 NM_017818 1.56037 0.000758505 1.07049 0.229576 C5orf4 NM_032385 1.56009 0.00164987 1.29686 0.0115808 TBX3 NM_016569 1.55595 0.000154871 -1.06955 0.101838 VEGFA NM_001025366 1.55503 0.00148515 -1.153 0.0665664 GIT1 NM_001085454 1.55425 0.000364051 -1.07444 0.142773 ANKRD20A2 NM_001012421 1.55422 7.57464E-05 -1.60273 5.80231E-05 MON2 NM_015026 1.55374 0.000770018 -1.11282 0.0890313 SENP6 NM_015571 1.55359 0.000155757 -1.21755 0.00342966 GPCPD1 NM_019593 1.54968 0.000763318 -1.17147 0.0289071 TRIM26 NM_003449 1.54823 0.00107366 -1.05248 0.378624 GJB5 NM_005268 1.54694 0.000265215 -1.00497 0.89699 DOPEY1 NM_015018 1.5465 0.000532491 -1.07353 0.174271 HMOX1 NM_002133 1.54644 0.00145446 1.08217 0.230335 EPHA2 NM_004431 1.54483 0.000312799 -1.05425 0.230731 PRKCD NM_006254 1.54281 0.000748249 1.00992 0.842857 CSTF3 NM_001326 1.54229 0.000831297 -1.51333 0.000986973 TMOD2 NM_014548 1.54034 0.000890945 -1.67559 0.00044793 TM7SF3 NM_016551 1.53949 1.94135E-06 -1.1331 0.000264847 SMAD5 NM_001001419 1.5387 0.000937568 -1.51535 0.00107669 GRAMD1B NM_020716 1.53464 0.000264373 1.03126 0.432224 AP1S1 NM_001283 1.53342 0.000137967 -1.06662 0.0967478 TMEM117 NM_032256 1.53254 0.000136453 -1.09023 0.043812 ZNFX1 NM_021035 1.53212 0.000217812 1.06207 0.146212 TAB3 NM_152787 1.53066 0.000450402 1.16899 0.0177911 ATP6AP1L NM_001017971 1.53052 0.00173646 1.36337 0.0056034 HSPBAP1 NM_024610 1.52961 0.000449308 -1.18783 0.0127399 SERTAD1 NM_013376 1.52599 0.000195913 1.12597 0.0212409 VPS13C NM_020821 1.52495 7.24432E-05 -1.16507 0.00363891 DNMBP NM_015221 1.52455 0.00171057 -1.39587 0.00409454 PID1 NM_017933 1.52202 0.00134988 1.24336 0.0145244 ZNF470 NM_001001668 1.51955 0.00091353 -1.07664 0.194695 RGS16 NM_002928 1.51646 0.000141018 -1.00899 0.774616 ARHGEF3 NM_001128615 1.51551 0.00102055 1.04467 0.418881 AGBL5 NM_021831 1.51547 0.000755288 -1.03892 0.44285 FAM167A NM_053279 1.51379 0.000173995 -1.01407 0.672741 GPC1 NM_002081 1.51372 0.000186358 1.09593 0.042721 SARS NM_006513 1.51205 0.000447732 -1.07367 0.142393 PRKAB1 NM_006253 1.50558 0.000259343 1.15723 0.0121287 CHST11 NM_018413 1.5055 0.00102336 1.1154 0.0843469 WWP1 NM_007013 1.50509 5.22524E-05 -1.01771 0.475664 SOCS4 NM_199421 1.50269 0.000148872 -1.21169 0.00269294 PTPRM NM_001105244 1.5018 0.000365633 1.06651 0.151657 PVRL1 NM_002855 1.50165 0.000822943 -1.13226 0.0504483 LPCAT3 NM_005768 1.50019 0.000565957 -1.07725 0.141018 PML NM_033240 1.50014 0.000601124 1.03149 0.494291 Supplemental Table 2: Microarray results sorted by p value

* Gene symbols in bold indicate genes that are downregulated in primary lung SCCs as compared to normal lung tissue (The Cancer Genome Atlas, https://tcga-data.nci.nih.gov/tcga/ ; Agilent G4502A_07 z-score ≤-0.5, frequency ≥20%)

Increased by Nutlin-3 (1.5 fold, p<0.05) Increased by shp63 (1.5 fold, p<0.05) Fold change p-value Fold change p-value Fold change p-value Fold change p-value Gene Gene RefSeq (Basal vs (Basal vs (Basal vs (Basal vs RefSeq (Basal vs (Basal vs (Basal vs (Basal vs symbol symbol Nutlin-3) Nutlin-3) shp63) shp63) shp63) shp63) Nutlin-3) Nutlin-3) BLOC1S2 NM_001001342 2.21835 1.00611E-07 -1.41037 2.8897E-06 GJB4 NM_153212 2.25408 1.03243E-06 2.04299 1.72792E-06 FAS NM_000043 2.42234 1.23621E-07 -1.23611 3.69392E-05 CENPT NM_025082 6.05155 2.7078E-06 1.14706 0.0425124 EDA2R NM_021783 3.91235 2.22471E-07 -1.08866 0.0109384 CD55 NM_001114752 1.64232 3.99001E-06 -1.00837 0.588385 ASCC3 NM_006828 1.63502 6.31373E-07 -1.43482 2.16727E-06 ZHX2 NM_014943 2.68533 9.97191E-06 -1.01576 0.682662 NYNRIN NM_025081 2.11833 6.95679E-07 1.14169 0.000668411 SLC6A20 NM_020208 1.57555 1.83225E-05 1.00113 0.955539 TMTC3 NM_181783 1.60713 8.85995E-07 -1.27405 1.29517E-05 SLC16A2 NM_006517 1.80058 2.34246E-05 -1.08987 0.0304655 BBS7 NM_176824 1.64432 1.42124E-06 -1.30981 1.62625E-05 TMPRSS11E NM_014058 8.60843 2.97654E-05 1.1414 0.26441 ZMAT3 NM_022470 2.34821 1.48634E-06 -1.00894 0.664692 TMEM27 NM_020665 1.64851 3.01761E-05 1.82907 1.42417E-05 GJB4 NM_153212 2.04299 1.72792E-06 2.25408 1.03243E-06 ST14 NM_021978 2.02069 0.000033025 -1.05481 0.19377 TM7SF3 NM_016551 1.53949 1.94135E-06 -1.1331 0.000264847 RHOV NM_133639 1.77795 0.000033356 -1.30895 0.000658903 ANKRA2 NM_023039 2.82915 2.05742E-06 -1.25507 0.000837047 FYB NM_001465 1.60967 3.37414E-05 1.44448 0.000093723 TNFRSF10B NM_003842 2.13481 2.41893E-06 -1.10805 0.00583219 HLA-C NM_002117 1.62478 4.97169E-05 1.07991 0.0424805 RAP2B NM_002886 1.85105 2.43015E-06 -1.19699 0.000319531 C15orf41 NM_032499 1.88488 5.34273E-05 1.11181 0.0381917 INPP5D NM_001017915 2.49904 2.6588E-06 -1.2906 0.000419376 KRTAP2-1 NM_001123387 1.75505 6.28425E-05 -1.18248 0.00647337 LRRC28 NM_144598 1.61108 2.85166E-06 1.05584 0.0123048 KRTAP2-4 NM_033184 1.69191 6.69355E-05 -1.10169 0.0338978 ABCA12 NM_173076 6.54111 3.04036E-06 -1.6659 0.000525859 RAPH1 NM_213589 1.84952 7.76805E-05 -1.07021 0.141478 FAM198B NM_001128424 3.43421 3.49012E-06 -1.20297 0.00563003 C2orf18 NM_017877 1.5762 0.000088593 -1.01684 0.587937 D32129/ ANK1 NM_020476 2.1718 3.74084E-06 1.14183 0.00370253 HLA-A NM_002116 1.76194 0.000100025 1.11661 0.0389098 ANXA4 NM_001153 1.76955 3.76997E-06 -1.1294 0.00163808 KRTAP5-2 NM_001004325 1.59637 0.000102335 -1.81588 3.90823E-05 C13orf31 NM_153218 2.89743 4.87894E-06 -1.00324 0.92427 ABHD4 NM_022060 1.74097 0.000109524 1.24466 0.00389225 LGALS9C NM_001040078 2.52638 5.28355E-06 1.34233 0.000491204 SIGLEC5 NM_003830 1.58477 0.000121496 1.31514 0.000918854 CCNG1 NM_004060 1.94246 5.38519E-06 -1.22271 0.000602154 TPRA1 NM_016372 1.54794 0.000132252 -1.1907 0.00443817 NRP2 NM_201266 1.90526 5.58604E-06 1.00937 0.666054 PEG10 NM_001040152 4.01868 0.000133417 -1.38342 0.0280132 XG NM_001141919 2.55639 6.25312E-06 -1.16774 0.00668795 HCP5 NM_006674 4.09159 0.000138244 1.47997 0.0163491 SPATA18 NM_145263 2.7807 7.02885E-06 -1.20002 0.00565653 BLNK NM_013314 1.72965 0.000140051 1.75968 0.000123994 CCDC29 ENST00000340460 2.4346 7.04559E-06 -1.27001 0.00123595 SCGB3A1 NM_052863 1.84277 0.000151349 -1.01377 0.769953 CCNK NM_001099402 1.74843 9.17456E-06 -1.20961 0.000641004 CPEB4 NM_030627 1.9589 0.000151776 1.47467 0.00127632 CYFIP2 NM_001037332 3.14283 9.67053E-06 -1.73274 0.00017708 CAPN13 NM_144575 2.37875 0.000164315 -1.0187 0.784105 GDF15 NM_004864 5.01123 9.73733E-06 1.28514 0.0121404 SLC28A3 NM_022127 6.2034 0.000166084 -1.23369 0.190956 LPAR5 NM_020400 1.68801 9.84076E-06 1.25489 0.000268272 SLC22A23 NM_015482 1.77169 0.000178064 -1.29056 0.00391258 CLCA2 NM_006536 3.69194 1.17354E-05 -1.34446 0.00377641 RABL3 NM_173825 1.54955 0.000179298 1.05392 0.18336 LGALS9B NM_001042685 2.34728 1.23188E-05 1.33683 0.000856018 ATP2B4 NM_001001396 1.99655 0.000196113 -1.12492 0.0896063 SLC30A1 NM_021194 1.56871 1.28104E-05 -1.10473 0.00447073 STAMBPL1 NM_020799 1.52187 0.000198063 -1.14412 0.0138177 NUPR1 NM_001042483 3.4275 1.40445E-05 1.17604 0.0283876 ADCY9 NM_001116 2.54315 0.00020458 -1.01641 0.832329 TMEM27 NM_020665 1.82907 1.42417E-05 1.64851 3.01761E-05 KCNK15 NM_022358 1.68844 0.000214728 -1.26499 0.00455287 GGT6 NM_001122890 2.3732 1.42617E-05 1.50408 0.000276636 HLA-B NM_005514 1.93051 0.000220385 1.17106 0.0379418 ZFYVE1 NM_021260 1.6534 1.45455E-05 1.44346 5.07726E-05 NTN4 NM_021229 1.94997 0.000222146 -1.13262 0.0771249 SESN1 NM_014454 3.13977 1.74955E-05 -1.55507 0.000740178 RUNX2 NM_001024630 1.96106 0.000228309 -1.01208 0.833204 HSD17B7 NM_016371 2.46002 1.93863E-05 -1.09381 0.0791587 KRT13 NM_153490 1.66627 0.000231278 -1.06968 0.172902 STARD5 NM_181900 3.81292 1.97357E-05 1.24623 0.0182978 MXRA5 NM_015419 1.92289 0.000234478 1.07598 0.233617 CSNK1G1 NM_022048 2.26261 1.97709E-05 -1.23264 0.00389668 HLA-H NR_001434 1.60263 0.000239195 1.07276 0.1373 BTG2 NM_006763 2.72228 0.000019824 -1.14734 0.032608 EDNRA NM_001957 1.73777 0.000245828 -1.00452 0.924451 RRM2B NM_015713 2.58747 1.98737E-05 1.0174 0.693387 GGT6 NM_001122890 1.50408 0.000276636 2.3732 1.42617E-05 SRGAP3 NM_014850 2.27808 2.23452E-05 -1.47618 0.000427106 TM4SF1 NM_014220 2.16285 0.000282541 1.40837 0.00609963 FDXR NM_024417 2.5297 2.25759E-05 1.00278 0.949314 TRIM55 NM_033058 2.81563 0.000282598 1.34018 0.0279119 BTBD10 NM_032320 1.7937 2.28907E-05 -1.25473 0.000936428 TP53INP2 NM_021202 2.39453 0.00030049 -1.24631 0.0414688 DFNB31 NM_015404 1.77607 2.35481E-05 1.42063 0.000165028 TMEM38A NM_024074 1.60565 0.000325758 -1.42852 0.000975723 APOBEC3C NM_014508 2.42161 2.48485E-05 -1.30136 0.00276233 C2orf54 NM_001085437 1.92973 0.000346517 -1.38991 0.00476585 NM_001098479/ SULF2 NM_018837 2.3994 2.48944E-05 -1.25794 0.00442335 HLA-F NM_018950 2.00945 0.00034727 1.00212 0.974194 C12orf5 NM_020375 2.66085 0.000026464 -1.25755 0.00702272 MTMR11 NM_001145862 1.60643 0.000354544 -1.2183 0.00937739 PLK3 NM_004073 1.98819 2.75059E-05 1.01088 0.751524 ASS1 NM_000050 1.58665 0.000356165 1.28164 0.00377759 DDB2 NM_000107 1.79205 2.79967E-05 -1.11308 0.0170022 SAMD9L NM_152703 2.53886 0.000369548 1.03829 0.676533 CCDC60 NM_178499 3.35876 2.80331E-05 -1.12138 0.112675 UPK2 NM_006760 1.75007 0.000381336 1.09396 0.150876 RPS27L NM_015920 2.24665 2.96912E-05 1.16705 0.0157151 LOC441204 AK056484 1.63171 0.000385725 1.04643 0.364891 MARCH8 NM_001002265 2.48073 3.00749E-05 -1.10127 0.0890706 SULT2B1 NM_004605 1.92062 0.000397221 1.07208 0.308344 CLN8 NM_018941 1.66291 3.03205E-05 1.07776 0.0364278 ZNF837 NM_001129730 1.57431 0.000399765 -1.08852 0.11088 PRKX NM_005044 2.42253 3.08165E-05 -1.43584 0.00102465 TLR3 NM_003265 1.72596 0.000401498 1.8135 0.000286227 TP53INP1 NM_033285 2.51711 3.11096E-05 1.02777 0.569202 IGFBP3 NM_001013398 2.22728 0.000406959 -1.04227 0.604173 BCL6 NM_001706 2.70686 0.000032873 1.4769 0.00128531 SYNPO NM_007286 1.5714 0.000409705 -1.08367 0.125998 DOCK8 NM_203447 2.20027 3.72673E-05 -1.02413 0.578973 MALL NM_005434 1.86003 0.000409902 1.1483 0.0729944 PRDM1 NM_001198 3.7006 3.77891E-05 1.22181 0.0382735 DUSP8 NM_004420 1.58527 0.000410734 -1.30119 0.00345217 ANK3 NM_020987 1.76615 3.79644E-05 -1.08366 0.0485788 ABCC1 NM_004996 1.59927 0.000424623 1.06943 0.199167 CD82 NM_002231 1.89499 0.000038595 1.20566 0.00443553 FNDC3A NM_001079673 1.65997 0.000435029 1.0635 0.264151 WDR63 NM_145172 5.29644 3.89077E-05 -1.291 0.0390339 TMEM45B NM_138788 1.66569 0.000442206 1.16943 0.0309922 SLC44A5 NM_152697 1.92537 4.24339E-05 1.01314 0.720067 FAM43A NM_153690 1.8248 0.000447583 1.17145 0.0493173 RFX7 NM_022841 1.81934 4.29851E-05 -1.42304 0.000344347 BTBD3 NM_014962 1.73799 0.000456457 -1.38003 0.00354877 RHOD NM_014578 2.03735 4.31801E-05 1.08721 0.0868309 SLC6A14 NM_007231 3.42823 0.00046478 -1.0413 0.747517 MARCH3 NM_178450 2.29434 4.41331E-05 -1.34077 0.00251156 C1orf116 NM_023938 1.65218 0.000472481 1.46547 0.00134935 MED23 NM_004830 1.60003 4.62882E-05 -1.14791 0.00518088 KLF4 NM_004235 1.54622 0.000494622 1.15977 0.0245599 FBN2 NM_001999 2.15256 4.75089E-05 -1.66964 0.000232297 GOT1 NM_002079 1.69706 0.0005283 -1.02569 0.651555 HSDL2 NM_032303 2.32311 4.75884E-05 -1.63889 0.000389255 CRB3 NM_139161 1.57199 0.000538111 -1.12434 0.0587908 ZBED2 NM_024508 2.4763 4.99851E-05 -1.35536 0.00341823 WIPI1 NM_017983 1.66852 0.000545496 1.00158 0.976724 WWP1 NM_007013 1.50509 5.22524E-05 -1.01771 0.475664 HLA-J NR_024240 1.68923 0.000562682 1.08436 0.197407 ABCA1 NM_005502 2.50979 5.25104E-05 1.08316 0.187428 TMTC2 NM_152588 1.94349 0.000573021 1.01713 0.811799 LRP1 NM_002332 1.8733 5.64337E-05 -1.14514 0.0178594 TPPP NM_007030 1.50139 0.000611867 -1.15268 0.0267722 ZNF383 NM_152604 1.79039 5.66698E-05 -1.03224 0.383624 CRIP2 NM_001312 1.95994 0.00066973 1.28953 0.0225326 ERAP2 NM_022350 1.9061 0.000057334 -1.15408 0.0164674 GRAMD1A NM_020895 1.50684 0.000671639 -1.17011 0.0216003 TNFRSF10C NM_003841 2.16703 5.76306E-05 1.06604 0.213561 SNORA80B NR_028374 1.67401 0.000727957 -1.24863 0.0157263 TMEM131 NM_015348 1.86529 5.80666E-05 -1.11981 0.0317482 TMEM173 NM_198282 1.50744 0.000735213 1.32487 0.00307191 BAX NR_027882 2.19809 5.80684E-05 -1.00116 0.980316 CITED2 NM_006079 1.79848 0.000760023 1.05807 0.424054 PTAFR NM_001164721 1.99888 5.96072E-05 1.45219 0.000673081 ALDH3A2 NM_001031806 1.54179 0.000774568 1.29058 0.00560839 ALOX5 NM_000698 1.82967 0.000060082 1.35653 0.000871347 C9orf150 NM_203403 1.6181 0.000776298 1.03132 0.587312 DSG3 NM_001944 3.92494 6.05255E-05 -1.74508 0.00198529 ANKRD22 NM_144590 7.64084 0.000778596 -1.77573 0.0603585 POLH NM_006502 2.51475 6.23214E-05 -1.51855 0.0013644 ATP1B1 NM_001677 1.82199 0.000792341 -1.43109 0.00544896 ERI2 NM_001142725 1.77527 6.62147E-05 -1.36016 0.000760398 OGDH NM_002541 1.51119 0.000794162 1.00109 0.981921 PARD6G NM_032510 1.7373 6.62173E-05 -2.24863 1.44644E-05 PLAUR NM_002659 1.89832 0.000807815 1.16342 0.0980235 PLAT NM_000930 3.28378 6.69448E-05 1.10956 0.206903 CHST6 NM_021615 1.54874 0.000811919 -1.12897 0.0652871 GM2A NM_000405 1.6961 6.74513E-05 1.22981 0.0025479 SLC25A36 NM_001104647 1.98075 0.000859248 1.15783 0.127169 LASS6 NM_203463 2.14037 6.89574E-05 -1.4066 0.00156381 MACC1 NM_182762 2.6926 0.000862686 -1.05858 0.634131 XPC NM_004628 2.19291 6.90867E-05 -1.28493 0.00550662 TMEM139 NM_153345 1.78501 0.000875825 -1.05017 0.493318 SMG6 NM_017575 1.57203 0.000069918 -1.12824 0.0105044 SLC25A23 NM_024103 1.64323 0.000904242 -1.14627 0.0720167 RCBTB1 NM_018191 1.62092 7.05828E-05 1.0003 0.992184 ANXA9 NM_003568 2.40084 0.000910221 -1.06261 0.573697 CSF1 NM_000757 2.46418 7.07422E-05 -1.01427 0.802985 AGER NM_001136 1.54118 0.000929614 1.01471 0.781754 VPS13C NM_020821 1.52495 7.24432E-05 -1.16507 0.00363891 LHFPL2 NM_005779 1.99994 0.00093629 1.16789 0.121358 C1orf57 NM_032324 1.56546 7.25697E-05 -1.29214 0.000647368 CXCL11 NM_005409 2.27938 0.000946235 1.19562 0.131095 KIAA0247 NM_014734 2.21875 0.00007459 1.09526 0.128533 HLA-G NM_002127 1.67773 0.000977226 1.09977 0.186597 CDKN1A NM_078467 3.0493 0.000074776 1.16957 0.0784663 GIPR NM_000164 1.55096 0.000999379 -1.00076 0.988859 C9orf169 NM_199001 1.68834 7.53234E-05 1.18763 0.00538678 IDH2 NM_002168 1.64807 0.00104434 -1.29466 0.011686 ANKRD20A2 NM_001012421 1.55422 7.57464E-05 -1.60273 5.80231E-05 FAM49A NM_030797 1.6947 0.00109056 1.80695 0.000701956 LRDD NM_018494 3.81619 7.67249E-05 -1.00858 0.920621 RNASE1 NM_198232 1.5908 0.00112226 1.16348 0.0527182 FBXO22 NM_147188 2.16597 7.81936E-05 -1.35218 0.00296006 INSL4 NM_002195 1.76328 0.00112358 -1.15813 0.0966914 ZNF79 NM_007135 2.08812 7.98454E-05 -1.03341 0.503347 ERRFI1 NM_018948 1.5056 0.00112415 -1.17908 0.0282537 TGFBRAP1 NM_004257 1.69592 8.52713E-05 -1.35998 0.000707774 SLC44A1 NM_080546 1.59432 0.0011779 -1.05853 0.371343 ABCC2 NM_000392 3.88651 8.60926E-05 1.14408 0.18466 PPARGC1A NM_013261 2.09507 0.00117884 -1.53026 0.00900875 STEAP3 NM_182915 1.58034 8.70281E-05 -1.1672 0.0055448 SHISA7 NM_001145176 1.54108 0.00117996 -1.03295 0.569956 CCDC90B NM_021825 1.62007 9.27976E-05 1.21357 0.00314119 AGVR6190 AY358245 1.53883 0.00118781 -1.16702 0.0419867 KIAA0040 NM_014656 1.61986 9.29281E-05 1.20597 0.00354876 P2RY6 NM_176796 2.04166 0.00119327 -1.23973 0.0685616 NINJ1 NM_004148 1.90133 9.29897E-05 1.0293 0.516003 MALT1 NM_006785 1.60502 0.00121002 -1.12164 0.117804 SFN NM_006142 1.72884 9.31404E-05 -1.51347 0.000278228 MUC21 NM_001010909 1.58193 0.00122703 -1.00131 0.982508 GNAI1 NM_002069 1.80312 9.69704E-05 -1.40107 0.0008578 OSBPL7 NM_145798 1.75636 0.00127299 1.04488 0.562914 CROT NM_001143935 2.24266 0.000103964 -1.21007 0.0220857 ATP1B2 NM_001678 1.51453 0.00127909 1.04485 0.441584 TMEM68 NM_152417 2.15029 0.000104066 -1.42226 0.0021009 TACC2 NM_206862 1.53422 0.00130991 1.04228 0.480991 SLC31A2 NM_001860 1.68577 0.000105538 1.09945 0.0496329 SLC22A18 NM_002555 1.8943 0.00132345 1.08646 0.357692 SLAMF7 NM_021181 1.61002 0.000106299 1.1315 0.0165321 HYAL1 NM_007312 1.56486 0.00132693 -1.25945 0.0146296 ZNF750 NM_024702 2.51145 0.000106824 -1.10122 0.184739 ECM1 NM_004425 1.57116 0.0013345 1.09324 0.190343 ZNF658 NM_033160 2.07725 0.000107415 -1.267 0.00780898 ACTA1 NM_001100 1.63407 0.00134306 -1.42853 0.00442758 CES2 NM_003869 2.31091 0.000108956 -1.13008 0.0905562 ADAM21 NM_003813 2.3937 0.00135221 1.21758 0.147208 LCE1B NM_178349 3.50606 0.000115393 -1.00759 0.932381 H1F0 NM_005318 1.58939 0.0013528 1.03874 0.549686 PROM2 NM_001165978 1.77083 0.000115821 1.16666 0.0156089 B3GALT4 NM_003782 1.70208 0.0013665 -1.05634 0.4595 VSIG1 NM_001170553 1.90645 0.000120308 -1.30643 0.00355795 TP53TG3 NM_016212 1.56969 0.00142851 -1.0077 0.900316 C1orf88 NM_181643 1.62546 0.00012379 1.2414 0.00280155 TNXA NR_001284 1.62303 0.00145085 1.06241 0.384218 BLNK NM_013314 1.75968 0.000123994 1.72965 0.000140051 EDN2 NM_001956 2.53842 0.00154119 -1.16679 0.27205 P4HA2 NM_004199 1.72177 0.000127203 -1.09892 0.064059 CITED4 NM_133467 1.68703 0.00155875 1.05137 0.503618 TNFRSF10A NM_003844 1.96825 0.000130118 -1.3375 0.00335289 IL8 NM_000584 2.00133 0.00156014 1.09715 0.363817 TEX9 NM_198524 2.58676 0.000131535 -1.19813 0.0509612 PNPLA2 NM_020376 1.52905 0.00157809 -1.16025 0.0556006 DEPDC7 NM_001077242 1.62754 0.000131686 -1.26509 0.00219429 NPAS2 NM_002518 1.81813 0.00158427 1.10346 0.277267 AK1 NM_000476 1.70929 0.000134531 1.06551 0.163123 GAB2 NM_080491 1.75708 0.00163092 -1.29574 0.0253415 TMEM117 NM_032256 1.53254 0.000136453 -1.09023 0.043812 DCLK2 NM_001040260 1.74204 0.0017173 -1.85546 0.00114115 COL17A1 NM_000494 1.70292 0.000137066 -1.12089 0.0370691 NR4A1 NM_002135 1.55241 0.00172179 -1.06061 0.374462 AP1S1 NM_001283 1.53342 0.000137967 -1.06662 0.0967478 ACO2 NM_001098 1.57292 0.00177254 1.09037 0.230041 TRPV6 NM_018646 1.96112 0.000140057 1.07072 0.221226 MFSD7 NM_032219 1.77099 0.00179142 -1.20415 0.0742916 DUSP14 NM_007026 1.78756 0.000140562 1.07774 0.13997 KLF12 NM_007249 1.61582 0.00179814 -1.35778 0.00928659 RGS16 NM_002928 1.51646 0.000141018 -1.00899 0.774616 ABCD1 NM_000033 1.6638 0.00180094 1.08104 0.32203 ZNF337 NM_015655 1.60538 0.000141872 -1.02042 0.576399 CLIC3 NM_004669 1.55864 0.00180755 -1.25871 0.0187764 PSTPIP2 NM_024430 1.89537 0.000147917 -1.74982 0.000249767 TP53I11 NM_001076787 1.54337 0.00181858 1.3245 0.00887825 SOCS4 NM_199421 1.50269 0.000148872 -1.21169 0.00269294 SYNPO2L NM_001114133 1.54916 0.00182618 -1.03814 0.563826 ZNF219 NM_016423 1.63032 0.000149765 -1.30583 0.00156183 LCE1D NM_178352 1.66956 0.00183405 1.0582 0.463341 SYNC NM_030786 1.68821 0.000150149 1.47965 0.000466864 GSTK1 NM_001143679 1.54133 0.0018849 1.00703 0.911799 TBX3 NM_016569 1.55595 0.000154871 -1.06955 0.101838 CLDN4 NM_001305 1.67907 0.00189556 1.05251 0.512162 SERINC5 NM_178276 1.59841 0.00015488 -1.01449 0.691664 CCND3 NM_001760 1.59229 0.00190145 -1.27088 0.0200096 SENP6 NM_015571 1.55359 0.000155757 -1.21755 0.00342966 FBXL19-AS1 NR_024348 1.60324 0.00193398 1.01352 0.84692 TRUB1 NM_139169 1.63369 0.000156731 -1.29277 0.00191616 TMEM52 NM_178545 1.50273 0.00195731 -1.07402 0.274606 MUC19 AK093065 3.03749 0.000159229 1.00695 0.935529 CD68 NM_001251 1.69517 0.00195878 1.20774 0.0613547 ACER2 NM_001010887 3.80954 0.000165199 -1.18906 0.151153 HLA-E NM_005516 1.58499 0.00199469 1.09381 0.234807 TNFRSF10D NM_003840 2.25792 0.000167578 -1.21476 0.0311733 TTYH1 NM_020659 1.5429 0.00199514 -1.17708 0.054179 TRIM22 NM_006074 2.6214 0.000167895 1.06031 0.454143 CRLF1 NM_004750 1.52165 0.00200572 -1.10657 0.158858 MDM4 NM_002393 1.67355 0.000170454 -1.19449 0.00941201 ANTXR1 NM_032208 1.62411 0.00202959 -1.07426 0.350745 PPM1D NM_003620 1.86771 0.000171568 -1.01508 0.761743 OTX2 NM_021728 1.57135 0.00209191 -1.11902 0.15257 FAM167A NM_053279 1.51379 0.000173995 -1.01407 0.672741 S100P NM_005980 2.07605 0.00210024 1.11169 0.36276 NADSYN1 NM_018161 1.84498 0.000175695 1.08867 0.135051 MUC1 NM_001018016 1.84987 0.00219652 -1.33514 0.0302873 RBL2 NM_005611 2.00394 0.000176275 -1.22879 0.016274 RASSF5 NM_182663 1.60477 0.00219677 1.17284 0.0778192 ZSCAN4 NM_152677 1.80472 0.000176751 -1.03549 0.471429 ERBB3 NM_001982 1.56374 0.0023206 -1.39452 0.00684722 RAB1A NM_004161 1.72043 0.000183093 -1.10386 0.0721618 DAGLA NM_006133 1.78509 0.00234373 -1.09065 0.36136 PRICKLE2 NM_198859 1.65402 0.000183372 -1.03027 0.473924 CSPG4 NM_001897 1.94102 0.00234765 -1.38906 0.0271365 GPC1 NM_002081 1.51372 0.000186358 1.09593 0.042721 CHST15 NM_015892 1.56486 0.00236069 1.01457 0.835421 MIR221 NR_029635 2.33182 0.000189346 -1.02456 0.724107 ADAM9 NM_003816 1.53757 0.00236795 -1.12989 0.123443 CEACAM1 NM_001712 3.19415 0.000190608 1.38245 0.0212126 LDB3 NM_007078 1.61008 0.00237164 -1.38852 0.00914614 TRAK1 NM_001042646 1.65903 0.000190847 1.05674 0.223807 FER1L6 NM_001039112 1.74735 0.00246941 1.05246 0.568139 SERPINB7 NM_003784 2.12398 0.000193802 -1.29575 0.0106663 VLDLR NM_003383 1.83102 0.00256947 1.24551 0.0715926 APAF1 NM_181861 1.67142 0.000194135 -1.01867 0.660947 CYP1A1 NM_000499 1.70598 0.00257877 -1.2661 0.0415335 CDH10 NM_006727 3.74252 0.000194156 -1.46161 0.0194915 GPSM3 NM_022107 1.61034 0.00260675 -1.23968 0.0394114 SERTAD1 NM_013376 1.52599 0.000195913 1.12597 0.0212409 ALDH3B2 NM_000695 1.51034 0.00266163 -1.36302 0.00753566 PRKD2 NM_016457 2.07834 0.000196851 -1.0018 0.975931 MGC16121 NR_024607 1.63103 0.00273046 -1.20282 0.0673826 PLCH2 NM_014638 1.66252 0.000198237 1.04341 0.336194 BAMBI NM_012342 1.63028 0.00273145 -1.35733 0.014549 TP53I3 NM_004881 2.76081 0.000198984 -1.16901 0.115224 DDX60L NM_001012967 1.84242 0.00279022 -1.07979 0.456072 TMEM63B NM_018426 1.70804 0.000202152 -1.04791 0.319267 TJP3 NM_014428 1.73843 0.00279729 -1.34206 0.0251526 DNAJC18 NM_152686 2.24605 0.000203327 1.08275 0.271248 SCNN1A NM_001038 1.83359 0.00283191 1.02403 0.810611 MCC NM_001085377 1.88013 0.000205366 -1.37041 0.00295433 SPINT1 NM_181642 1.66174 0.00287795 -1.26495 0.0394941 TAF3 NM_031923 2.03834 0.000205502 -1.39048 0.00390216 ACTA2 NM_001141945 1.54084 0.00288438 -1.3241 0.0134449 STX6 NM_005819 1.70307 0.000217216 -1.33161 0.00235845 KYNU NM_003937 1.51655 0.00289074 1.02188 0.752459 ZNFX1 NM_021035 1.53212 0.000217812 1.06207 0.146212 STEAP4 NM_024636 2.39584 0.00289177 -1.58994 0.0260776 RALGDS NM_006266 2.0723 0.000218011 -1.28304 0.0120513 RILP NM_031430 1.51068 0.00289699 -1.2258 0.032724 TTYH3 NM_025250 1.94659 0.000230054 1.0106 0.851913 RAG1AP1 NM_018845 1.58754 0.00295862 1.00809 0.915765 C20orf112 NM_080616 1.60648 0.000230647 1.15905 0.0173471 CYB5R1 NM_016243 1.5218 0.003137 -1.1089 0.192615 SLC6A4 NM_001045 2.07686 0.000231563 1.24464 0.019783 BRP44L NM_016098 1.57761 0.00314194 -1.02039 0.792341 FAM83A NM_032899 1.83367 0.000231645 -1.05885 0.301982 CASZ1 NM_001079843 1.84044 0.00328786 -1.27643 0.065944 ZNF114 NM_153608 2.16482 0.000235126 -1.55769 0.00199605 MYOZ3 NM_001122853 1.52672 0.00331612 -1.0419 0.576327 KRT15 NM_002275 1.85139 0.000248257 1.23322 0.0137202 CLCNKA NM_004070 1.54586 0.00338106 -1.39478 0.00891124 EFNB1 NM_004429 2.28608 0.00024827 -1.51034 0.00354418 MAP2K1 NM_002755 1.64151 0.00342497 -1.28977 0.033296 ARAP1 NM_015242 2.24885 0.000250939 -1.18913 0.0582418 AQP3 NM_004925 1.99907 0.00343193 -1.03671 0.762895 FBXW7 NM_033632 2.48314 0.000253063 -1.34145 0.0166194 KRTAP1-5 NM_031957 1.56115 0.00355439 -1.34279 0.0152605 XDH NM_000379 1.9385 0.000253347 -2.00128 0.000210721 ACSL1 NM_001995 1.50445 0.0035753 -1.08008 0.311515 FOS NM_005252 2.47124 0.000255319 -1.03946 0.628087 TMPRSS13 NM_001077263 1.51449 0.00358104 -1.13265 0.139495 CEL NM_001807 2.77683 0.000256173 1.11516 0.261639 PPP1R3C NM_005398 2.78247 0.00359548 -1.05409 0.768222 PRKAB1 NM_006253 1.50558 0.000259343 1.15723 0.0121287 PPL NM_002705 1.73809 0.00360664 -1.12747 0.254709 SEMA3F NM_004186 1.56414 0.000259987 1.13791 0.0244394 ACP2 NM_001610 1.56629 0.00362694 -1.16958 0.0997723 GRAMD1B NM_020716 1.53464 0.000264373 1.03126 0.432224 MEIS2 NM_172316 1.539 0.00363072 -1.05357 0.500554 GJB5 NM_005268 1.54694 0.000265215 -1.00497 0.89699 VTCN1 NM_024626 1.76591 0.00373419 -1.92355 0.0022207 ZNF385A NM_015481 3.60289 0.000266815 -1.55518 0.0140092 ELF3 NM_001114309 2.09139 0.003761 -1.52168 0.0262056 ZNF563 NM_145276 1.89819 0.00026773 -1.00913 0.872053 B3GNT2 NM_006577 1.69575 0.00390924 -1.07026 0.484279 CELF2 NM_001025077 2.43653 0.000269799 -1.00415 0.95787 MMP13 NM_002427 4.64335 0.00403798 -1.07852 0.784639 NOTCH1 NM_017617 1.75131 0.000270523 -1.24038 0.00974397 MIR23B NR_029664 1.65637 0.00409136 -1.20276 0.0964644 CCDC51 NM_024661 1.80709 0.000273288 -1.15472 0.0429846 SYNGR3 NM_004209 1.70615 0.00413257 -1.41889 0.0181019 TLR3 NM_003265 1.8135 0.000286227 1.72596 0.000401498 GBP2 NM_004120 2.15025 0.00419416 1.00642 0.963194 FRMPD2 NM_001018071 3.8179 0.000294293 -1.16548 0.248386 EFNA1 NM_004428 1.56552 0.00426125 -1.42999 0.00953579 MOSPD1 NM_019556 1.59208 0.00030297 -1.15029 0.0242505 TMEM53 NM_024587 1.50713 0.00432165 -1.2582 0.0310092 GAL3ST4 NM_024637 2.89111 0.000308504 1.08108 0.439865 CGN NM_020770 1.50483 0.00445646 -1.25469 0.03266 CMBL NM_138809 2.92479 0.000310597 -1.48963 0.0123972 GALNT5 NM_014568 1.76071 0.00449316 1.62809 0.00766896 ABTB2 NM_145804 1.57134 0.000311141 1.24386 0.00492311 MFAP2 NM_002403 1.50053 0.00464735 -1.1223 0.179728 CABYR NM_012189 2.40388 0.000311852 -1.07818 0.374485 FGFBP1 NM_005130 2.00572 0.00465258 -1.26872 0.122598 EPHA2 NM_004431 1.54483 0.000312799 -1.05425 0.230731 FLG NM_002016 2.1356 0.00475068 1.06986 0.639937 KITLG NM_000899 2.21253 0.000314988 -2.0692 0.000443957 STK17B NM_004226 1.75418 0.00476792 -1.1688 0.190581 TMEM156 NM_024943 1.69486 0.000317118 -1.20312 0.0153403 LBH NM_030915 1.51225 0.00481477 -1.46437 0.00644436 KCNG1 NM_002237 1.74368 0.000329332 -1.02558 0.629757 SLC2A3 NM_006931 1.85744 0.00484574 -1.46873 0.0247808 UNC13B NM_006377 1.57453 0.00033287 -1.11506 0.0516352 LIPH NM_139248 1.91469 0.00493033 -1.12105 0.378868 AEN NM_022767 1.86486 0.000336477 -1.26825 0.012145 CEACAM6 NM_002483 4.05916 0.00506308 1.3804 0.268605 GIT1 NM_001085454 1.55425 0.000364051 -1.07444 0.142773 KIAA0895 NM_001100425 1.52693 0.00510062 -1.33335 0.0193715 PTPRM NM_001105244 1.5018 0.000365633 1.06651 0.151657 UQCRFS1 NM_006003 1.65441 0.00513787 -1.08764 0.406346 FAM129B NM_022833 1.58725 0.00036873 1.42123 0.00105973 TBC1D19 NM_018317 1.50406 0.00514871 -1.0478 0.55985 RABGGTA NM_004581 1.63041 0.000384464 1.04567 0.370762 CYP4B1 NM_001099772 1.50233 0.0051625 -1.22797 0.0488379 ISCU NM_014301 2.15796 0.000389418 -1.20253 0.0578584 TMOD1 NM_003275 1.52229 0.0051779 -1.23805 0.0479722 TRIM3 NM_006458 1.59389 0.000396655 1.0996 0.0898131 PLAC8 NM_016619 1.65088 0.00523024 2.13599 0.00111466 DUOX1 NM_017434 1.92355 0.000401713 -1.14426 0.0880252 MAP1B NM_005909 1.51702 0.00541929 -1.41113 0.0106275 STEAP2 NM_152999 1.70211 0.000402415 -1.26418 0.00862524 GPR110 NM_153840 1.82683 0.00549731 1.08321 0.509556 F2RL2 NM_004101 1.58801 0.000409563 1.20547 0.0118406 PDZK1IP1 NM_005764 1.53883 0.00565464 -1.23406 0.0575991 ZNF561 NM_152289 1.7743 0.000412726 -1.3907 0.00338515 PLCL2 NM_015184 2.15972 0.000413907 -1.09284 0.280244 MAST4 NM_001164664 1.8926 0.000416368 -1.09801 0.188492 ZNF37A NM_001007094 1.91839 0.000416857 -1.33205 0.00894985 MARVELD2 NM_001038603 1.75914 0.00041975 -1.14863 0.0572785 RGL1 NM_015149 1.56058 0.000436517 1.30081 0.00323167 ZNF195 NM_001130520 1.63257 0.00044718 -1.24244 0.00932506 DQX1 NM_133637 3.67582 0.000447675 1.03008 0.821097 SARS NM_006513 1.51205 0.000447732 -1.07367 0.142393 HSPBAP1 NM_024610 1.52961 0.000449308 -1.18783 0.0127399 TAB3 NM_152787 1.53066 0.000450402 1.16899 0.0177911 ZNF654 NM_018293 2.31597 0.000475544 -1.19907 0.0869764 DTX4 NM_015177 1.63641 0.000476815 1.05667 0.307807 C6orf138 NM_001013732 3.25572 0.000480356 1.16262 0.254529 DSC3 NM_024423 1.73519 0.000497535 -1.48957 0.00172403 PLTP NM_006227 4.1896 0.000517195 -1.44309 0.059059 RETSAT NM_017750 1.88902 0.000520008 1.06255 0.385559 GPR87 NM_023915 2.28451 0.000529798 -1.53001 0.00639841 DOPEY1 NM_015018 1.5465 0.000532491 -1.07353 0.174271 DOCK4 NM_014705 1.77811 0.000532856 1.27874 0.0123392 TSPAN5 NM_005723 1.89495 0.000533915 -1.34686 0.00916645 CYP4F3 NM_000896 3.06999 0.000536236 -1.38536 0.0423273 MR1 NM_001531 1.90948 0.000557762 1.15173 0.0938792 LPCAT3 NM_005768 1.50019 0.000565957 -1.07725 0.141018 TRIAP1 NM_016399 1.98195 0.000566926 -1.22283 0.0426393 PML NM_033240 1.50014 0.000601124 1.03149 0.494291 C16orf5 NM_013399 1.80735 0.000604446 1.32795 0.00928823 PANK1 NM_148977 1.56039 0.000610807 1.03621 0.477717 GOLGB1 NM_004487 1.56974 0.000631261 1.08942 0.139073 FAM84A NM_145175 1.69435 0.000635107 1.13012 0.0878809 SESN2 NM_031459 2.08496 0.000641775 -1.02503 0.76136 FAM49A NM_030797 1.80695 0.000701956 1.6947 0.00109056 SMEK1 NM_032560 1.59167 0.000716615 -1.14001 0.057136 PXT1 NM_152990 2.73998 0.000734549 -1.03468 0.768113 APOBEC3F NM_145298 1.59716 0.000737716 -1.11918 0.0885048 PORCN NM_022825 1.69226 0.000738922 1.04726 0.459458 BNC1 NM_001717 1.58989 0.000740777 -1.3144 0.00536639 PRKCD NM_006254 1.54281 0.000748249 1.00992 0.842857 AGBL5 NM_021831 1.51547 0.000755288 -1.03892 0.44285 WDR8 NM_017818 1.56037 0.000758505 1.07049 0.229576 GPCPD1 NM_019593 1.54968 0.000763318 -1.17147 0.0289071 MON2 NM_015026 1.55374 0.000770018 -1.11282 0.0890313 SEMA3B NM_004636 1.58053 0.000773795 1.16392 0.037936 CSTA NM_005213 1.63235 0.000789424 -1.78323 0.000415477 ASB1 NM_001040445 1.64865 0.000792537 -1.46794 0.00216455 MICALCL NM_032867 2.19389 0.000792651 -1.75481 0.00281284 PVRL1 NM_002855 1.50165 0.000822943 -1.13226 0.0504483 CSTF3 NM_001326 1.54229 0.000831297 -1.51333 0.000986973 KIAA1199 NM_018689 1.64305 0.000835801 1.30164 0.00871143 C20orf72 BC016869 1.56212 0.000840601 -1.46012 0.00157265 CYP4F11 NM_021187 1.85215 0.000852015 1.01461 0.842974 FITM2 NM_001080472 1.68009 0.000876769 1.0292 0.647046 IP6K2 NM_016291 1.58877 0.000883349 -1.03568 0.53751 LDB1 NM_003893 1.57225 0.000884051 1.01677 0.760211 TMOD2 NM_014548 1.54034 0.000890945 -1.67559 0.00044793 PLEKHG1 NM_001029884 2.33285 0.000903078 -1.08993 0.419528 ZNF470 NM_001001668 1.51955 0.00091353 -1.07664 0.194695 SMAD5 NM_001001419 1.5387 0.000937568 -1.51535 0.00107669 PLCXD2 NM_153268 1.56723 0.000961013 -1.17513 0.0353631 MAPKBP1 NM_014994 2.12991 0.00098527 1.02662 0.778901 DCP1B NM_152640 1.64049 0.00100226 -1.11377 0.134342 TP53TG1 AB007455 1.62725 0.00101994 -1.08931 0.20679 ARHGEF3 NM_001128615 1.51551 0.00102055 1.04467 0.418881 CHST11 NM_018413 1.5055 0.00102336 1.1154 0.0843469 CASP1 NM_033292 2.32519 0.00102881 -2.42816 0.000849068 FAM27A NR_024060 1.56378 0.00103293 -1.28718 0.00851896 CASP10 NM_032977 2.30972 0.00103879 -1.10779 0.35606 AREG NM_001657 3.04529 0.00106163 -1.21804 0.207648 TRIM26 NM_003449 1.54823 0.00107366 -1.05248 0.378624 ANTXR2 NM_058172 2.14968 0.00108088 1.52533 0.00962883 SMTN NM_134269 1.61007 0.00108357 1.01942 0.75063 PLAC8 NM_016619 2.13599 0.00111466 1.65088 0.00523024 HHAT NM_001170580 1.57052 0.00112038 -1.06583 0.30325 PCLO NM_033026 1.61158 0.00115782 -1.12025 0.119925 JHDM1D NM_030647 1.83407 0.00117028 1.15742 0.117216 KIAA1217 NM_019590 1.60807 0.00122029 1.29514 0.01125 GLS2 NM_013267 3.437 0.00125359 -1.71344 0.0240176 NCKAP5 NM_207363 1.9656 0.00125399 -1.42811 0.0128577 MDM2 NM_002392 2.48701 0.00129666 -1.34287 0.0598702 SLFN5 NM_144975 1.66842 0.00132615 1.13418 0.120586 PID1 NM_017933 1.52202 0.00134988 1.24336 0.0145244 SERPINE2 NM_001136529 2.53757 0.00135013 -2.01406 0.00392062 PLAU NM_002658 1.60346 0.00139759 -1.06624 0.34437 HSD17B7P2 NR_003086 2.02619 0.00141797 -1.04082 0.679215 GXYLT1 NM_173601 1.69241 0.00142854 -1.34293 0.0117431 HMOX1 NM_002133 1.54644 0.00145446 1.08217 0.230335 KCTD11 NM_001002914 1.62831 0.00147629 -1.02424 0.721969 RAD51C NM_058216 2.69459 0.00147886 -2.55021 0.00183561 UNC5B NM_170744 1.6755 0.00147997 -1.09 0.264326 VEGFA NM_001025366 1.55503 0.00148515 -1.153 0.0665664 SCRIB NM_182706 1.62556 0.00149391 -1.04125 0.554214 F2R NM_001992 1.93888 0.00153301 -1.14168 0.19834 RGS2 NM_002923 3.4142 0.00156672 -3.51989 0.00142763 METTL8 NM_024770 1.78378 0.00160095 -1.25462 0.0406447 KAT2B NM_003884 1.67069 0.00162244 -1.0306 0.679163 GHR NM_000163 2.40668 0.00164533 1.00046 0.997062 RNASE7 NM_032572 2.06712 0.00164686 -2.60625 0.000570133 C5orf4 NM_032385 1.56009 0.00164987 1.29686 0.0115808 GLDC NM_000170 2.0888 0.00166307 -1.07549 0.498072 TLE4 NM_007005 1.66043 0.00169491 1.15179 0.104968 DNMBP NM_015221 1.52455 0.00171057 -1.39587 0.00409454 LAMB3 NM_001017402 1.65614 0.00171531 -1.31208 0.0158292 ATP6AP1L NM_001017971 1.53052 0.00173646 1.36337 0.0056034 VANGL2 NM_020335 1.73963 0.00173701 -1.01348 0.86582 TRANK1 NM_014831 1.71384 0.00174138 -1.04775 0.554479 ETV5 NM_004454 1.73512 0.0017493 -1.39372 0.0110103 Supplemental Table 3: shRNA vector and sequence information

Alternate shRNA Target Name number Backbone Sequence

ACTL6A Baf53a 1 pLKO CGGTACTTCAAGTGTCAGATT ACTL6A Baf53a 2 pLKO GCTTTCCTTGAAATGCACTTA ACTR6 Arp6 1 pLKO CCGAGATAATCCTTCCGAATT ACTR6 Arp6 2 pLKO GCTGTTTCCAAGGGTAGGTTA CAPN13 pLKO CCATGTTTATATGTAGCGAAA DMAP1 1 pLKO CAGCTTTATCTCCACGATGAT DMAP1 2 pLKO CCCAAGGACACCATCATTGAT ep400 p400 1 pLKO GCCAAACTTTACAGGAAGAAT ep400 p400 2 pLKO CCTCTCCAGTAAATAGACCTT GBP2 pLKO GCCAATATGTAACATACTCTA H2A.Z pTRIPZ GAAGAAAGGACAACAGAAGACT HCP5 pLKO GATTCTCCTCACACTTACAAT IGFBP3 1 pLKO GCCTCGATTTATATTTCTGTT IGFBP3 2 pLKO GCCGTAGAGAAATGGAAGACA Ino80 1 pLKO GCCCAGAAGAACTGTAAGGAA Ino80 2 pLKO CGTAACCTGTTTCTCACCAAT Kat5 Tip60 1 pLKO CCTCAATCTCATCAACTACTA Kat5 Tip60 2 pLKO CAAGTGTCTTCAGCGTCATTT NTN4 pLKO GCACTTTACTACCTACCACTT p53 pLL3.7 GACTCCAGTGGTAATCTAC pTRIPZ, pLKO- p63 CCGAGCTATGTCAGTACTATT Tet-On RUVBL1 Pontin, Tip49 1 pLKO CCGGCCAACTTGCTTGCTAAA RUVBL1 Pontin, Tip49 2 pLKO GCCACAGAATTCGACCTTGAA RUVBL2 Reptin, Tip48 1 pLKO CCGTGATGTAACAAGGATTGA RUVBL2 Reptin, Tip48 2 pLKO CGAGAAAGACACGAAGCAGAT SAMD9L 1 pLKO GCAGACAGTATTGCACTAAAT SAMD9L 2 pLKO CATCGCTACATAGAACATTAT SMARCA2 Brm 1 pLKO GCTGAGAAACTGTCACCAAAT SMARCA2 Brm 2 pLKO CCAAACCTGTAGTGAGCGATT SRCAP 1 pLKO GCCTTGATGGAACGGTTCAAT SRCAP 2 pLKO GCCAGCAAGCAGACTCATATT ST14 pLKO GCACGAGAAAGTGAATGGCTT TP53INP2 pLKO CCAGGGAATAAGCCAAATTAA VPS72 YL-1 1 pLKO GCAGGTTCATAAGAAGCGGAA VPS72 YL-1 2 pLKO GAGATGTCTAGTCCTCAGAAA YEATS4 GAS-41 1 pLKO CGGTAATGTTGCTCGGTATTT YEATS4 GAS-41 2 pLKO AGGGTGTTACTATCGTTAAAC ZHX2 pLKO CCCACTAAATACTACCAAATA Supplemental Table 4: Antibody Information

Protein/Epitope Source Catalog Number

AcH2A.Z Abcam ab18262-100 AcH4 Upstate (Millipore) 06-866 ACTL6A Abcam ab3882 ACTR6 Abcam ab101644 BrdU Santa Cruz Biotechnology, Inc. SC-51514 DMAP1 (ChIP) Santa Cruz Biotechnology, Inc. SC-47583 DMAP1 (WB) Abcam ab2848 H2A.Z Abcam ab4174 H3K27me3 Upstate (Millipore) 07-449 H3K4me3 Abcam ab8580 H3K9Ac Upstate (Millipore) 06-942 H4K20me2 Upstate (Millipore) 07-367 H4K20me3 Upstate (Millipore) 07-463 Nucleolin Santa Cruz Biotechnology, Inc. SC-8031 p21 Santa Cruz Biotechnology, Inc. SC-817 p53 Calbiochem OP43 p63 Santa Cruz Biotechnology, Inc. SC-8431 p63-alpha Santa Cruz Biotechnology, Inc. SC-8344 RNAPII (S5P) Covance MMS-134R RUVBL1 Abcam 2943C1a RUVBL2 Bethyl A302-536A RUVBL2 Santa Cruz Biotechnology, Inc. SC-34750 SRCAP Santa Cruz Biotechnology, Inc. SC-133312 VPS72 Bethyl A303-115A Supplemental Table 5: Q-PCR primer sequences

QRT-PCR Primers ChIP Q-PCR Primers Location (distance in Gene Forward Primer Reverse Primer Gene base pairs to Forward Primer Reverse Primer transcription start site) 18S GCCGCTAGAGGTGAAATTCTTG CTTTCGCTCTGGTCCGTCTT 14-3-3-s -1881 AAACCCTGTAGCATTAGCCCAGA TCTCTTTGCCACAAGGAGGAGTA ACTL6A CCACTGCAGTCACTTCGCCAGT ACTTCATCTCCCCCGTACACGC ACTA2 38272 GCCCTTTCTGCCCCTTTCTGTT TGCAAACCATGCCTGCATCTGC ACTR6 ACTACGGCTGCGGTGTGGTT AGGAATAACCGACACATTTTCATGGCT APAF1 -592 CGGCTCTTCACCTCAGACATG CCCTGGGCTTGTCGTCCTA BAX TGGAGCTGCAGAGGATGATTG AAACATGTCAGCTGCCACTCG BAX -102 TTGGGCTCACAAGTTAGAGACAAG CCTGGATCTAGCAATATAGCCCAC DMAP1 AGTTTCTGCCGCGGCTTTGC TCAAGGGTCAGTGCCTGGGT BLNK 37 ACTTGACTATGTGCTCGGGCAAGT TGGTCTCAAGGGTTCCGGCCA FAM49A TTGGCCAGACAGCAGCTAAGCT TCCCATCCCAGCAAACCTGGAA DR5 657 GCCAGGGAACAGAGCGC CCCCACTGGATTCGGGA GJB4 AAGGAAGCAGCTACTGGACCCA TACCTGCCCAATGGTCCACAGA EDN2 2261 CAGGGGCATAGGGTAGCTGCAA TGCTAGTCTCCCAGACACCTGCT H2A.Z CCTCGTCACTTGCAACTTGCT CAAGGAATCCAGGCATCCTTT FAS 783 GTTGGAGAGAGGAGCGGAACT CGGACCTTTGGCTTGGCT IGFBP3 TGTGACAAGAAGGATTTTAT CCCGCTTCCTGCCTTTG FDXR -43 GGGCAGGAGCGGGCT ACAGCAACCTGCAAGTGGATC Ino80 GCTGAATGCTCGTCGCAGGAAA ACTGGTGAGCAAGCTTTCGGCT GADD45A 1496 GGGTTGCCTGATTGTGGATC ACATCTCGGCTGAAAGTCCAG MDM2 GGCGATTGGAGGGTAGACCT CACATTTGCCTGGATCAGCA GGT6 -84 AATGGGGCAGGCTCACATGCAG GGGTGGGGGTGGAATCCAGAACA NTN4 CTGCATCAGCAGCCACACAGAC AGTGCAGAAAACCCCTGCGCAT GJB4 -3 CTCATTGGCCCAGAAAGCCCCAC TGCCCTATTCGGTCCTCACCCT p21 CTGGAGACTCTCAGGGTCGAAA GATTAGGGCTTCCTCTTGGAGAA IGFBP3 4078 GAGGGCAAGACCTGCCAA GTTGAGTAAGAATTGCCCTCAAGAG p400 TCAATGACGAGCAGCAAGCCCT TTGGTGACCCACTTCAAGGCGA MASPIN -213 CCCTTCCTGCCCGAACAT TGTTGTCTGCACAGCTTCCAA PLAC8 TTCTCTCCCAGGCCACAAGACA GGCGCCTGAGCTTGCATTTTCA MDM2 780 TCAAGTTCAGACACGTTCCGAA CTGGGAAAATGCATGGTTTAAATA RUVBL1 CACTACGAAGACGCAGCGCA ATGACGCCACATGCCTCTCG NOXA -290 TCCAGCGTTTGCAGATGGT AACGAGGTGGGAGGAGAAGG RUVBL2 TGAGCGAATCGGTGCCCACT TGACCCACCATGCCTTGCGA NTN4 69285 TGTTGAGGCTTGCAGTGGCCT ACCTTTCTATCTGCGCACTGGAGA SAMD9L AGACAGCAAAAGTTCAAATGGCCTGT CCAGTCTCTCTCTGGAAATGCAGGA p21 -2283 AGCAGGCTGTGGCTCTGATT CAAAATAGCCACCAGCCTCTTCT SMARCA2 ACCGAGTGCTGCTTTTCTGCCA TTGGTGGTGCCATCAAGGCGTA p53R2 2268 AATCTTGACCTTAAATTGTTGTCCTGA CCCAGTTGGAAGACATGCCT SRCAP ACGACCCAGGTAAAGACGCCCA TGGATGGTCTTCCCAAGCCCCA PCNA -238 GGGACCCGATCTCCACATATG CGCCTCTTTGACTCCTGAACC Tip60 ACGGAAGGTGGAGGTGGTTTCA GCGGCTCCATTCTGGGGAAAAA PLAC8 47 TCCCCTTTCACGTAGTTTTCATTTGTGG ACAAGGTTCCGAGCAGGAAATGTC VPS72 AAGGTCAACACCCCGGCTGGTA ACTTCCGACTGTCAGAGCCGTCA PUMA 1313 TCAGTGTGTGTGTCCGACTGTC GGCAGGGCCTAGCCCA YEATS4 ACCCTAATGAAAGACCTGTAACCCTGT TCCCCAGCATTGCATTGGTGTCT SAMD9L 28902 ACTGTGCCCCTGCCAACAACA TGGTCACCGACTGCCTGGAA ZHX2 ATCAGACTCCGACTGCGTCCCT AAGACGGAGCGTCCCGTTGA ST14 19578 AGGAAATGCTGGGGGTTGCGA CCCACTCCCCAACCAGGGGTAA TLR3 -1915 GCACTCATGACTCAATGCAAAC CACTTTAGGAGATTGCTTGAGC TMEM27 467 TGTGGCTTGAAAGTTGGGGCAGT ACAGCCCCAAATACTCCTGGAAGT TP53INP2 9507 AGGCTGAAGCCCAGGCTGAGA AAAGCCAGCTGCTTCTGCCCC ZHX2 -1935 AGAGGTTGGGAGGAGATCAGGCA TCTCAGCCTCATTTGGTACCGGC ZHX2 -444 CACAGTCCCACGCAAAGGGT ACTGTTGATCTTGACCACGTGGAGT ZHX2 -19 AGCTCGGGTGGTGGTATCGT TGGGGAATCTACGCCAAAACCCA ZHX2 460 ATGGGACTTGGCCGGGTTTGTG CACCCGCAAAAAGAGCCTGCA ZHX2 4071 TGGTTGTTGAGTTGGCAGGGAGG ACTGCTCCCAGGGCCCTTCTTT ZHX2 81229 GCCTCTGCCCTGCGTGGTTA AGGCATGTGCCCGGTTCTGA ZHX2 136095 CCCCAAAACCCCTTGGGCCTTG CCAGACATGTCACGGCACATTTGGA ZHX2 197644 GCAGGGAGTGACATCAACCCAAGC CCTGGCTGCCCTTCTCACACAAA