bioRxiv preprint doi: https://doi.org/10.1101/2021.01.30.428928; this version posted February 1, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 Agri-environment nectar chemistry suppresses parasite social epidemiology in an 2 important pollinator (1,#) (2) (2) (2,3) (1) 3 Arran J. Folly* , Hauke Koch , Iain W. Farrell , Philip C. Stevenson , Mark J.F. Brown 4 (1) Centre for Ecology, Evolution and Behaviour, Department of Biological Sciences, School of Life Sciences and the Environment, Royal 5 Holloway University of London, Egham, UK (2) Royal Botanic Gardens, Kew, UK (3) Natural Resources Institute, University of Greenwich, 6 Kent, UK 7 8 *Corresponding author: Arran J. Folly:
[email protected] 9 #Current address: Virology Department, Animal and Plant Health Agency, Surrey, UK 10 11 Emergent infectious diseases are a principal driver of biodiversity loss globally. The population 12 and range declines of a suite of North American bumblebees, a group of important pollinators, 13 have been linked to emergent infection with the microsporidian Nosema bombi. Previous work 14 has shown that phytochemicals in pollen and nectar can negatively impact parasites in individual 15 bumblebees, but how this relates to social epidemiology and by extension whether plants can be 16 effectively used as disease management strategies remains unexplored. Here we show that 17 caffeine, identified in the nectar of Sainfoin, a constituent of agri-environment schemes, 18 significantly reduced N.