MINIREVIEW rRNA Binding Sites and the Molecular Mechanism of Action of Chinwe U. Chukwudi 4433–4441 the Tetracyclines CHEMISTRY; BIOSYNTHESIS Quinolone Amides as Antitrypanosomal Lead Compounds with Georg Hiltensperger, Nina Hecht, 4442–4452 In Vivo Activity Marcel Kaiser, Jens-Christoph Rybak, Alexander Hoerst, Nicole Dannenbauer, Klaus Müller-Buschbaum, Heike Bruhn, Harald Esch, Leane Lehmann, Lorenz Meinel, Ulrike Holzgrabe MECHANISMS OF ACTION: PHYSIOLOGICAL EFFECTS Comparison of the Exposure Time Dependence of the Activities Tuo Yang, Stanley C. Xie, Pengxing 4501–4510 of Synthetic Ozonide Antimalarials and Dihydroartemisinin Cao, Carlo Giannangelo, James against K13 Wild-Type and Mutant Plasmodium falciparum McCaw, Darren J. Creek, Susan A. Strains Charman, Nectarios Klonis, Leann Tilley Antifungal Properties of Cationic Phenylene Ethynylenes and Harry C. Pappas, Rina Sylejmani, 4519–4529 Their Impact on ␤-Glucan Exposure Matthew S. Graus, Patrick L. Donabedian, David G. Whitten, Aaron K. Neumann The Investigational Drug VT-1129 Is a Highly Potent Inhibitor Andrew G. S. Warrilow, Josie E. Parker, 4530–4538 of Cryptococcus Species CYP51 but Only Weakly Inhibits the Claire L. Price, W. David Nes, Human Enzyme Edward P. Garvey, William J. Hoekstra, Robert J. Schotzinger, Diane E. Kelly, Steven L. Kelly Glutathione-Disrupted Biofilms of Clinical Pseudomonas William Klare, Theerthankar Das, 4539–4551 aeruginosa Strains Exhibit an Enhanced Antibiotic Effect and a Amaye Ibugo, Edwina Buckle, Mike Novel Biofilm Transcriptome Manefield, Jim Manos Antimalarial Benzoxaboroles Target Plasmodium falciparum Ebere Sonoiki, Andres Palencia, 4886–4895 Leucyl-tRNA Synthetase Denghui Guo, Vida Ahyong, Chen Dong, Xianfeng Li, Vincent S. Hernandez, Yong-Kang Zhang, Wai Choi, Jiri Gut, Jennifer Legac, Roland Cooper, M. R. K. Alley, Yvonne R. Freund, Joseph DeRisi, Stephen Cusack, Philip J. Rosenthal Imidazo[1,2-a]Pyridine-3-Carboxamides Are Active Garrett C. Moraski, Yong Cheng, 5018–5022 Antimicrobial Agents against Mycobacterium avium Infection Sanghyun Cho, Jeffrey W. Cramer, In Vivo Alexander Godfrey, Thierry Masquelin, Scott G. Franzblau, Marvin J. Miller, Jeffery Schorey Dimethyl Sulfoxide Protects Escherichia coli from Rapid Hongfei Mi, Dai Wang, Yunxin Xue, 5054–5058 Antimicrobial-Mediated Killing Zhi Zhang, Jianjun Niu, Yuzhi Hong, Karl Drlica, Xilin Zhao

Instructions to Authors are available at http://journalitas.asm.org/t/46519. Continued on following page Continued from preceding page AUGUST 2016 • VOLUME 60 • NUMBER 8

MECHANISMS OF RESISTANCE Role of Plasmodium vivax Dihydropteroate Synthase Wichai Pornthanakasem, Pinpunya 4453–4463 Polymorphisms in Sulfa Drug Resistance Riangrungroj, Penchit Chitnumsub, Wanwipa Ittarat, Darin Kongkasuriyachai, Chairat Uthaipibull, Yongyuth Yuthavong, Ubolsree Leartsakulpanich Silver and Nitrate Oppositely Modulate Antimony Susceptibility Juvana M. Andrade, Elio H. Baba, 4482–4489 through Aquaglyceroporin 1 in Leishmania (Viannia) Species Ricardo A. Machado-de-Avila, Carlos Chavez-Olortegui, Cynthia P. Demicheli, Frédéric Frézard, Rubens L. Monte-Neto, Silvane M. F. Murta Mutations in pepQ Confer Low-Level Resistance to Bedaquiline Deepak Almeida, Thomas Ioerger, 4590–4599 and Clofazimine in Mycobacterium tuberculosis Sandeep Tyagi, Si-Yang Li, Khisimuzi Mdluli, Koen Andries, Jacques Grosset, Jim Sacchettini, Eric Nuermberger In Vitro Emergence of High Persistence upon Periodic Joran Elie Michiels, Bram 4630–4637 Aminoglycoside Challenge in the ESKAPE Pathogens Van den Bergh, Natalie Verstraeten, Maarten Fauvart, Jan Michiels The MisR Response Regulator Is Necessary for Intrinsic Cationic Justin L. Kandler, Concerta L. Holley, 4690–4700 Antimicrobial Peptide and Aminoglycoside Resistance in Jennifer L. Reimche, Vijaya Dhulipala, Neisseria gonorrhoeae Jacqueline T. Balthazar, Artur Muszyn´ ski, Russell W. Carlson, William M. Shafer Transcriptome Proﬁling of Antimicrobial Resistance in Ariane Khaledi, Monika Schniederjans, 4722–4733 Pseudomonas aeruginosa Sarah Pohl, Roman Rainer, Ulrich Bodenhofer, Boyang Xia, Frank Klawonn, Sebastian Bruchmann, Matthias Preusse, Denitsa Eckweiler, Andreas Dötsch, Susanne Häussler A Transposon Screen Identiﬁes Genetic Determinants of Vibrio Tobias Dörr, Fernanda Delgado, 4757–4763 cholerae Resistance to High-Molecular-Weight Antibiotics Benjamin D. Umans, Matthew A. Gerding, Brigid M. Davis, Matthew K. Waldor Acquired Tolerance to Ivermectin and Moxidectin after Drug Cécile Ménez, Mélanie Alberich, Dalia 4809–4819 Selection Pressure in the Nematode Caenorhabditis elegans Kansoh, Alexandra Blanchard, Anne Lespine Horizontal Transfer of Carbapenemase-Encoding Plasmids and C. A. Hardiman, R. A. Weingarten, S. 4910–4919 Comparison with Hospital Epidemiology Data Conlan, P. Khil, J. P. Dekker, A. J. Mathers, A. E. Sheppard, J. A. Segre, K. M. Frank

Serum Albumin and Ca2؉ Are Natural Competence Inducers in German Matias Traglia, Brettni Quinn, 4920–4929 the Human Pathogen Acinetobacter baumannii Sareda T. J. Schramm, Alfonso Soler-Bistue, Maria Soledad Ramirez

Substrate Inhibition of VanA by D-Alanine Reduces Vancomycin Lizah T. van der Aart, Nicole Lemmens, 4930–4939 Resistance in a VanX-Dependent Manner Willem J. van Wamel, Gilles P. van Wezel New Insight into Daptomycin Bioavailability and Localization Rym Boudjemaa, Romain Briandet, 4983–4990 in Staphylococcus aureus Bioﬁlms by Dynamic Fluorescence Matthieu Revest, Cédric Jacqueline, Imaging Jocelyne Caillon, Marie-Pierre Fontaine-Aupart, Karine Steenkeste

Distribution of Staphylococcal Cassette Chromosome (SCC) Hsiao-Jan Chen, Yu-Tzu Lin, 5006–5009 mec Element Types in Fusidic Acid-Resistant Staphylococcus Wei-Chun Hung, Jui-Chang Tsai,

epidermidis and Identiﬁcation of a Novel SCC7684 Element Po-Ren Hsueh, Lee-Jene Teng

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Absence of Association between Polymorphisms in the RING E3 Mathieu Gendrot, Bécaye Fall, Marylin 5010–5013 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Madamet, Mansour Fall, Conventional Antimalarial Drugs in Plasmodium falciparum Khalifa Ababacar Wade, Rémy Isolates from Dakar, Senegal Amalvict, Aminata Nakoulima, Nicolas Benoit, Silman Diawara, Yaya Diémé, Bakary Diatta, Boubacar Wade, Bruno Pradines

Complete Nucleotide Sequence of an IncI2 Plasmid Jian Sun, Xing-Ping Li, Run-Shi Yang, 5014–5017

Coharboring blaCTX-M-55 and mcr-1 Liang-Xing Fang, Wei Huo, Shu-Min Li, Peng Jiang, Xiao-Ping Liao, Ya-Hong Liu Spread of Plasmids Carrying Multiple GES Variants Gaelle Cuzon, Pierre Bogaerts, Caroline 5040–5043 Bauraing, Te-Din Huang, Rémy A. Bonnin, Youri Glupczynski, Thierry Naas Frequency of BKC-1-Producing Klebsiella Species Isolates Willames M. B. S. Martins, Adriana G. 5044–5046 Nicoletti, Silvia R. Santos, Jorge L. M. Sampaio, Ana C. Gales

Binding of Daptomycin to Anionic Lipid Vesicles Is Reduced in Tala O. Khatib, Heather Stevenson, 5051–5053 the Presence of Lysyl-Phosphatidylglycerol Michael R. Yeaman, Arnold S. Bayer, Antje Pokorny SUSCEPTIBILITY Antimicrobial Susceptibility and Clonality of Clinical Javier Fernández, Melissa J. Karau, 4793–4798 Ureaplasma Isolates in the United States Scott A. Cunningham, Kerryl E. Greenwood-Quaintance, Robin Patel Repurposing of Aspirin and Ibuprofen as Candidate Anti- Adepemi O. Ogundeji, Carolina H. 4799–4808 Cryptococcus Drugs Pohl, Olihile M. Sebolai Differences in the Molecular Epidemiology and Antibiotic Larry K. Kociolek, Dale N. Gerding, 4896–4900 Susceptibility of Clostridium difﬁcile Isolates in Pediatric and James R. Osmolski, Sameer J. Patel, Adult Patients David R. Snydman, Laura A. McDermott, David W. Hecht Pyrazinamide Is Active against Mycobacterium tuberculosis Alice L. den Hertog, Sandra Menting, 4956–4960 Cultures at Neutral pH and Low Temperature Richard Pfeltz, Matthew Warns, Salman H. Siddiqi, Richard M. Anthony In Vitro Synergism between Azithromycin or Terbinaﬁne and Sabrina R. Itaqui, Camila M. Verdi, 5023–5025 Topical Antimicrobial Agents against Pythium insidiosum Juliana S. M. Tondolo, Thaisa S. da Luz, Sydney H. Alves, Janio M. Santurio, Érico S. Loreto Differential Antimicrobial Susceptibilities of Granulicatella Ammara Mushtaq, Kerryl E. 5036–5039 adiacens and Abiotrophia defectiva Greenwood-Quaintance, Nicolynn C. Cole, Peggy C. Kohner, Sherry M. Ihde, Gregory J. Strand, Lance W. Harper, Abinash Virk, Robin Patel Extensive Shared Chemosensitivity between Malaria and Aditya S. Paul, Cristina K. Moreira, 5059–5063 Babesiosis Blood-Stage Parasites Brendan Elsworth, David R. Allred, Manoj T. Duraisingh Multicenter Comparison of the Etest and EUCAST Methods for M.-E. Bougnoux, E. Dannaoui, I. 5088–5091 Antifungal Susceptibility Testing of Candida Isolates to Accoceberry, A. Angoulvant, E. Bailly, Micafungin F. Botterel, S. Chevrier, T. Chouaki, M. Cornet, F. Dalle, A. Datry, A. Dupuis, A. Fekkar, J. P. Gangneux, J. Guitard, C. Hennequin, Y. Le Govic, P. Le Pape, D. Maubon, S. Ranque, M. Sautour, B. Sendid, J. Chandenier

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ANALYTICAL PROCEDURES Immunoassay Analysis of Kanamycin in Serum Using the J. A. Dijkstra, A. J. Voerman, B. 4646–4651 Tobramycin Kit Greijdanus, D. J. Touw, J. W. C. Alffenaar Simultaneous Determination of Eight ␤-Lactam Antibiotics, Tiphaine Legrand, Dominique 4734–4742 Amoxicillin, Cefazolin, Cefepime, Cefotaxime, Ceftazidime, Vodovar, Nicolas Tournier, Nihel Cloxacillin, Oxacillin, and Piperacillin, in Human Plasma by Khoudour, Anne Hulin Using Ultra-High-Performance Liquid Chromatography with Ultraviolet Detection Discovery and Analysis of Natural-Product Compounds Yanmei Hu, Megan Keniry, Stephanie 4820–4829 Inhibiting Protein Synthesis in Pseudomonas aeruginosa O. Palmer, James M. Bullard ANTIVIRAL AGENTS Large-Scale Screening and Identiﬁcation of Novel Ebola Virus Manu Anantpadma, Jennifer 4471–4481 and Marburg Virus Entry Inhibitors Kouznetsova, Hang Wang, Ruili Huang, Andrey Kolokoltsov, Rajarshi Guha, Aaron R. Lindstrom, Olena Shtanko, Anton Simeonov, David J. Maloney, Wendy Maury, Douglas J. LaCount, Ajit Jadhav, Robert A. Davey

Discovery of a Broad-Spectrum Antiviral Compound That Dong-Hoon Chung, Jennifer E. 4552–4562 Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Golden, Robert S. Adcock, Chad E. Interferon-Independent Antiviral State Schroeder, Yong-Kyu Chu, Julie B. Sotsky, Daniel E. Cramer, Paula M. Chilton, Chisu Song, Manu Anantpadma, Robert A. Davey, Aminul I. Prodhan, Xinmin Yin, Xiang Zhang In Vivo Rectal Mucosal Barrier Function Imaging in a Large- Gracie Vargas, Kathleen Listiak 4600–4609 Animal Model by Using Confocal Endomicroscopy: Vincent, Yong Zhu, David Szafron, Implications for Injury Assessment and Use in HIV Prevention Tyra Caitlin Brown, Paula Patricia Studies Villarreal, Nigel Bourne, Gregg N. Milligan, Massoud Motamedi

Antiviral Activity of Favipiravir (T-705) against a Broad Range D. Jochmans, S. van Nieuwkoop, S. L. 4620–4629 of Paramyxoviruses In Vitro and against Human Smits, J. Neyts, R. A. M. Fouchier, B. G. Metapneumovirus in Hamsters van den Hoogen Biochemical Characterization of the Active Anti-Hepatitis C Maryam Ehteshami, Sijia Tao, Tugba 4659–4669 Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Ozturk, Longhu Zhou, Jong Hyun Cho, Prodrug Compared to Sofosbuvir and BMS-986094 Hongwang Zhang, Sheida Amiralaei, Jadd R. Shelton, Xiao Lu, Ahmed Khalil, Robert A. Domaoal, Richard A. Stanton, Justin E. Suesserman, Biing Lin, Sam S. Lee, Franck Amblard, Tony Whitaker, Steven J. Coats, Raymond F. Schinazi In Vitro Characterization of Human Cytomegalovirus- Hetalkumar D. Patel, Pavel Nikitin, 4961–4971 Targeting Therapeutic Monoclonal Antibodies LJP538 and Thomas Gesner, James J. Lin, David T. LJP539 Barkan, Claudio Ciferri, Andrea Carﬁ, Tahmineh Akbarnejad Yazdi, Peter Skewes-Cox, Brigitte Wiedmann, Nadine Jarousse, Weidong Zhong, Adam Feire, Christy M. Hebner

Optimization of a Class of Tryptophan Dendrimers That Inhibit Eva Rivero-Buceta, Liang Sun, Belén 5064–5067 HIV Replication Leads to a Selective, Speciﬁc, and Low- Martínez-Gualda, Elisa G. Doyagüez, Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71 Kim Donckers, Ernesto Quesada, María-José Camarasa, Leen Delang, Ana San-Félix, Johan Neyts, Pieter Leyssen Continued on following page Continued from preceding page AUGUST 2016 • VOLUME 60 • NUMBER 8

EPIDEMIOLOGY AND SURVEILLANCE

Global Dissemination of blaKPC into Bacterial Species beyond Krystyna M. Kazmierczak, Douglas J. 4490–4500 Klebsiella pneumoniae and In Vitro Susceptibility to Biedenbach, Meredith Hackel, Sharon Ceftazidime-Avibactam and Aztreonam-Avibactam Rabine, Boudewijn L. M. de Jonge, Samuel K. Bouchillon, Daniel F. Sahm, Patricia A. Bradford Prospective Study of Plasmodium vivax Malaria Recurrence Lina Zuluaga-Idárraga, Silvia Blair, 4610–4619 after Radical Treatment with a Chloroquine-Primaquine Sheila Akinyi Okoth, Venkatachalam Standard Regimen in Turbo, Colombia Udhayakumar, Paula L. Marcet, Ananias A. Escalante, Neal Alexander, Carlos Rojas Isolation and Characterization of Escherichia coli Sequence Muhanad Mohamed, Connie Clabots, 4638–4645 Type 131 and Other Antimicrobial-Resistant Gram-Negative Stephen B. Porter, Paul Thuras, Bacilli from Clinical Stool Samples from Veterans James R. Johnson Assessment of the In Vitro Activity of Ceftazidime-Avibactam Meredith Hackel, Krystyna M. 4677–4683 against Multidrug-Resistant Klebsiella spp. Collected in the Kazmierczak, Daryl J. Hoban, INFORM Global Surveillance Study, 2012 to 2014 Douglas J. Biedenbach, Samuel K. Bouchillon, Boudewijn L. M. de Jonge, Gregory G. Stone In Vitro Susceptibility of Global Surveillance Isolates of Wright W. Nichols, Boudewijn L. M. 4743–4749 Pseudomonas aeruginosa to Ceftazidime-Avibactam (INFORM de Jonge, Krystyna M. Kazmierczak, 2012 to 2014) James A. Karlowsky, Daniel F. Sahm Changes in the Frequencies of ␤-Lactamase Genes among Mariana Castanheira, Rodrigo E. 4770–4777 Enterobacteriaceae Isolates in U.S. Hospitals, 2012 to 2014: Mendes, Ronald N. Jones, Helio S. Activity of Ceftazidime-Avibactam Tested against ␤-Lactamase- Sader Producing Isolates Antifungal Susceptibility Testing of Ascomycetous Yeasts Sergio Álvarez-Pérez, Marta E. García, 5026–5028 Isolated from Animals Teresa Peláez, Eva Martínez-Nevado, José L. Blanco Detection of the mcr-1 Colistin Resistance Gene in Carbapenem- Hua Yu, Fen Qu, Bin Shan, Bin Huang, 5033–5035 Resistant Enterobacteriaceae from Different Hospitals in China Wei Jia, Cha Chen, Aiqing Li, Minhui Miao, Xin Zhang, Chunmei Bao, Yunmin Xu, Kalyan D. Chavda, Yi-Wei Tang, Barry N. Kreiswirth, Hong Du, Liang Chen

First Report of blaIMP-14 on a Plasmid Harboring Multiple Drug Nicole Stoesser, Anna E. Sheppard, 5068–5071 Resistance Genes in Escherichia coli Sequence Type 131 Gisele Peirano, Robert P. Sebra, Tarah Lynch, Luke W. Anson, Andrew Kasarskis, Mary R. Motyl, Derrick W. Crook, Johann D. Pitout Travelers Can Import Colistin-Resistant Enterobacteriaceae, Odette J. Bernasconi, Esther Kuenzli, 5080–5084 Including Those Possessing the Plasmid-Mediated mcr-1 Gene João Pires, Regula Tinguely, Alessandra Carattoli, Christoph Hatz, Vincent Perreten, Andrea Endimiani EXPERIMENTAL THERAPEUTICS Efﬁcacy of Lysophosphatidylcholine in Combination with R. Parra Millán, M. E. Jiménez Mejías, 4464–4470 Antimicrobial Agents against Acinetobacter baumannii in V. Sánchez Encinales, R. Ayerbe Algaba, Experimental Murine Peritoneal Sepsis and Pneumonia Models A. Gutiérrez Valencia, M. E. Pachón Ibáñez, C. Díaz, J. Pérez del Palacio, L. F. López Cortés, J. Pachón, Y. Smani Thioridazine as Chemotherapy for Mycobacterium avium Devyani Deshpande, Shashikant 4652–4658 Complex Diseases Srivastava, Sandirai Musuka, Tawanda Gumbo

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Phenotypic Screening In Vitro of Novel Aromatic Amidines M. R. Simões-Silva, A. S. G. Nefertiti, 4701–4707 against Trypanosoma cruzi J. S. De Araújo, M. M. Batista, P. B. Da Silva, M. T. Bahia, R. S. Menna- Barreto, B. P. Pavão, J. Green, A. A. Farahat, A. Kumar, D. W. Boykin, M. N. C. Soeiro In Vivo Pharmacodynamic Target Assessment of Delaﬂoxacin Alexander J. Lepak, David R. Andes 4764–4769 against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine Lung Infection Model Investigation of Elimination Rate, Persistent Subpopulation Yanmin Hu, Henry Pertinez, Fatima 4778–4785 Removal, and Relapse Rates of Mycobacterium tuberculosis by Ortega-Muro, Laura Alameda-Martin, Using Combinations of First-Line Drugs in a Modiﬁed Cornell Yingjun Liu, Alessandro Schipani, Mouse Model Geraint Davies, Anthony Coates In Vitro and In Vivo Characterization of the Novel Christopher M. Tan, Charles J. Gill, Jin 4830–4839 Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor Wu, Nathalie Toussaint, Jingjun Yin, AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase Takayuki Tsuchiya, Charles G. Garlisi, David Kaelin, Peter T. Meinke, Lynn Miesel, David B. Olsen, Armando Lagrutta, Hideyuki Fukuda, Ryuta Kishii, Masaya Takei, Kouhei Oohata, Tomoko Takeuchi, Taku Shibue, Hisashi Takano, Akinori Nishimura, Yasumichi Fukuda, Sheo B. Singh

Atovaquone and ELQ-300 Combination Therapy as a Novel Allison M. Stickles, Martin J. 4853–4859

Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria Smilkstein, Joanne M. Morrisey, Yuexin Li, Isaac P. Forquer, Jane X. Kelly, Sovitj Pou, Rolf W. Winter, Aaron Nilsen, Akhil B. Vaidya, Michael K. Riscoe Revisiting the Concept of Targeting Only Bacillus anthracis Itai Glinert, Elad Bar-David, Assa 4878–4885 Toxins as a Treatment for Anthrax Sittner, Shay Weiss, Josef Schlomovitz, Amir Ben-Shmuel, Adva Mechaly, Zeev Altboum, David Kobiler, Haim Levy

Targeting the Cytochrome bc1 Complex of Leishmania Parasites Diana Ortiz, Isaac Forquer, Jan Boitz, 4972–4982 for Discovery of Novel Drugs Radika Soysa, Carolyn Elya, Audrey Fulwiler, Aaron Nilsen, Tamsen Polley, Michael K. Riscoe, Buddy Ullman, Scott M. Landfear Efﬁcacy of the Novel Antibiotic POL7001 in Preclinical Models Cristina Cigana, Francesca Bernardini, 4991–5000 of Pseudomonas aeruginosa Pneumonia Marcella Facchini, Beatriz Alcalá-Franco, Camilla Riva, Ida De Fino, Alice Rossi, Serena Ranucci, Pauline Misson, Eric Chevalier, Maj Brodmann, Michel Schmitt, Achim Wach, Glenn E. Dale, Daniel Obrecht, Alessandra Bragonzi Virulence and Experimental Treatment of Trichoderma Katihuska Paredes, Javier Capilla, 5029–5032 longibrachiatum, a Fungus Refractory to Treatment Emilio Mayayo, Josep Guarro Modeling Meropenem Treatment, Alone and in Combination P. Gagetti, F. Pasteran, M. P. Martinez, 5047–5050 with Daptomycin, for KPC-Producing Klebsiella pneumoniae M. Fatouraei, J. Gu, R. Fernandez, L. Strains with Unusually Low Carbapenem MICs Paz, W. E. Rose, A. Corso, A. E. Rosato Eravacycline Pharmacokinetics and Challenges in Deﬁning Abrar K. Thabit, Marguerite L. 5072–5075 Humanized Exposure In Vivo Monogue, David P. Nicolau

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Inhibition of LpxC Increases Antibiotic Susceptibility in Meritxell García-Quintanilla, José M. 5076–5079 Acinetobacter baumannii Caro-Vega, Marina R. Pulido, Patricia Moreno-Martínez, Jerónimo Pachón, Michael J. McConnell Comparative Efficacies of Tedizolid Phosphate, Linezolid, and Arnold S. Bayer, Wessam Abdelhady, 5092–5096 Vancomycin in a Murine Model of Subcutaneous Catheter- Liang Li, Rachelle Gonzales, Yan Q. Related Biofilm Infection Due to Methicillin-Susceptible and Xiong -Resistant Staphylococcus aureus CLINICAL THERAPEUTICS Pharmacokinetics of Vancomycin in Elderly Patients Aged over Laurent Bourguignon, Yoann 4563–4567 80 Years Cazaubon, Guillaume Debeurme, Constance Loue, Michel Ducher, Sylvain Goutelle Individual or Combined Effects of Meropenem, Imipenem, Yung-Chih Wang, Shu-Chen Kuo, 4670–4676 Sulbactam, Colistin, and Tigecycline on Biofilm-Embedded Ya-Sung Yang, Yi-Tzu Lee, Acinetobacter baumannii and Biofilm Architecture Chun-Hsiang Chiu, Ming-Fen Chuang, Jung-Chung Lin, Feng-Yee Chang, Te-Li Chen Cefazolin versus Nafcillin for Methicillin-Sensitive S. Pollett, S. M. Baxi, G. W. Rutherford, 4684–4689 Staphylococcus aureus Bloodstream Infection in a California S. B. Doernberg, P. Bacchetti, H. F. Tertiary Medical Center Chambers Moxifloxacin Improves Treatment Outcomes in Patients with Jung-Yien Chien, Shun-Tien Chien, 4708–4716 Ofloxacin-Resistant Multidrug-Resistant Tuberculosis Wei-Yih Chiu, Chong-Jen Yu, Po-Ren Hsueh Predicting Antibiotic Resistance in Urinary Tract Infection Yaakov Dickstein, Yuval Geffen, Steen 4717–4721 Patients with Prior Urine Cultures Andreassen, Leonard Leibovici, Mical Paul New Regimen for Continuous Infusion of Vancomycin in Stefano Cristallini, Maya Hites, Hakim 4750–4756 Critically Ill Patients Kabtouri, Jason A. Roberts, Marjorie Beumier, Frederic Cotton, Jeffrey Lipman, Frédérique Jacobs, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone Determination of MIC Breakpoints for Second-Line Drugs Xubin Zheng, Rongrong Zheng, Yi Hu, 4786–4792 Associated with Clinical Outcomes in Multidrug-Resistant Jim Werngren, Lina Davies Forsman, Tuberculosis Treatment in China Mikael Mansjö, Biao Xu, Sven Hoffner Systematic Review and Meta-analysis of Clinical and Economic Styliani Karanika, Suresh Paudel, 4840–4852 Outcomes from the Implementation of Hospital-Based Christos Grigoras, Alireza Kalbasi, Antimicrobial Stewardship Programs Eleftherios Mylonakis Development and Evaluation of a Gentamicin Pharmacokinetic Eva Germovsek, Alison Kent, Tuuli 4869–4877 Model That Facilitates Opportunistic Gentamicin Therapeutic Metsvaht, Irja Lutsar, Nigel Klein, Drug Monitoring in Neonates and Infants Mark A. Turner, Mike Sharland, Elisabet I. Nielsen, Paul T. Heath, Joseph F. Standing, on behalf of the neoGent Collaboration Validation and Application of a Dried Blood Spot Assay for Ben Knippenberg, Madhu Page-Sharp, 4940–4955 Biofilm-Active Antibiotics Commonly Used for Treatment of Sam Salman, Ben Clark, John Dyer, Prosthetic Implant Infections Kevin T. Batty, Timothy M. E. Davis, Laurens Manning

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PHARMACOLOGY Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship Sam Nightingale, Tran Thi Hong Chau, 4511–4518 with CYP2B6 c.516G¡T Genotype and Perturbed Blood-Brain Martin Fisher, Mark Nelson, Alan Barrier Due to Tuberculous Meningitis Winston, Laura Else, Daniel F. Carr, Steven Taylor, Andrew Ustianowski, David Back, Munir Pirmohamed, Tom Solomon, Jeremy Farrar, M. Estée Törok, Saye Khoo, on behalf of the PARTITION-Vietnam Study Group Isavuconazole Population Pharmacokinetic Analysis Using Laura L. Kovanda, Amit V. Desai, 4568–4576 Nonparametric Estimation in Patients with Invasive Fungal Qiaoyang Lu, Robert W. Townsend, Disease (Results from the VITAL Study) Shahzad Akhtar, Peter Bonate, William W. Hope Effect of Obesity on the Population Pharmacokinetics of Abdulaziz S. Alobaid, Steven C. Wallis, 4577–4584 Meropenem in Critically Ill Patients Paul Jarrett, Therese Starr, Janine Stuart, Melissa Lassig-Smith, Jenny Lisette Ordóñez Mejia, Michael S. Roberts, Jeffrey Lipman, Jason A. Roberts Pharmacokinetics of Tedizolid in Morbidly Obese and Manjunath P. Pai 4585–4589 Covariate-Matched Nonobese Adults Physiologically Based Pharmacokinetic Model of Rifapentine Todd J. Zurlinden, Garrett J. Eppers, 4860–4868 and 25-Desacetyl Rifapentine Disposition in Humans Brad Reisfeld Inﬂuence of Renal Replacement Modalities on Amikacin Claire Roger, Steven C. Wallis, Laurent 4901–4909 Population Pharmacokinetics in Critically Ill Patients on Muller, Gilbert Saissi, Jeffrey Lipman, Continuous Renal Replacement Therapy Jean-Yves Lefrant, Jason A. Roberts Antibacterial Efﬁcacy of Eravacycline In Vivo against Gram- Marguerite L. Monogue, Abrar K. 5001–5005 Positive and Gram-Negative Organisms Thabit, Yukihiro Hamada, David P. Nicolau Biopharmaceutical Characterization of Nebulized Antimicrobial Danilo Cesar Galindo Bedor, Sandrine 5085–5087 Agents in Rats: 5. Oseltamivir Carboxylate Marchand, Isabelle Lamarche, Julian Laroche, Davi Pereira de Santana, William Couet LETTERS TO THE EDITOR High Prevalence of Heterogeneously Glycopeptide-Intermediate Björn Berglund, Carina Claesson, 5097–5098 Coagulase-Negative Staphylococci in Sternal Wounds Lennart E. Nilsson, Håkan Hanberger Detection of Colistin Resistance Gene mcr-1 in Hypervirulent Dan-xia Gu, Yong-lu Huang, Ji-hua 5099–5100 Klebsiella pneumoniae and Escherichia coli Isolates from an Ma, Hong-wei Zhou, Ying Fang, Infant with Diarrhea in China Jia-chang Cai, Yan-yan Hu, Rong Zhang In Vitro Activity of Fusidic Acid-Containing Combinations Sarah L. Bowler, Caressa N. Spychala, 5101 against Carbapenem-Resistant Acinetobacter baumannii Christi L. McElheny, Roberta T. Clinical Strains Mettus, Yohei Doi

Mobilization of blaBKC-1 by ISKpn23? Sally R. Partridge 5102–5104

Reply to “Mobilization of blaBKC-1 by ISKpn23?” Adriana Giannini Nicoletti, 5105 Marcelo F. M. Marcondes, Willames M. B. S. Martins, Luiz G. P. Almeida, Marisa F. Nicolás, Ana T. R. Vasconcelos, Vitor Oliveira, Ana Cristina Gales

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ERRATA Erratum for Norgan et al., Carbapenem- and Colistin-Resistant Andrew P. Norgan, Jarred M. Freese, 5106 Enterobacter cloacae from Delta, Colorado, in 2015 Patricia M. Tuin, Scott A. Cunningham, Patricio R. Jeraldo, Robin Patel

Erratum for McGann et al., Escherichia coli Harboring mcr-1 Patrick McGann, Erik Snesrud, Rosslyn 5107

and blaCTX-M on a Novel IncF Plasmid: First Report of mcr-1 in Maybank, Brendan Corey, Ana C. Ong, the United States Robert Clifford, Mary Hinkle, Timothy Whitman, Emil Lesho, Kurt E. Schaecher AUTHOR CORRECTION Correction for Hasassri et al., An Immunocompromised Child M. Earth Hasassri, Thomas G. Boyce, 5108 with Bloodstream Infection Caused by Two Escherichia coli Andrew P. Norgan, Scott A. Strains, One Harboring NDM-5 and the Other Harboring Cunningham, Patricio R. Jeraldo, Scott J. OXA-48-Like Carbapenemase Weissman, Robin Patel, Ritu Banerjee, Jason M. Pogue (Commentator), Keith S. Kaye (Commentator)