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TRP Mediation
molecules Review Remedia Sternutatoria over the Centuries: TRP Mediation Lujain Aloum 1 , Eman Alefishat 1,2,3 , Janah Shaya 4 and Georg A. Petroianu 1,* 1 Department of Pharmacology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates; [email protected] (L.A.); Eman.alefi[email protected] (E.A.) 2 Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates 3 Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman 11941, Jordan 4 Pre-Medicine Bridge Program, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates; [email protected] * Correspondence: [email protected]; Tel.: +971-50-413-4525 Abstract: Sneezing (sternutatio) is a poorly understood polysynaptic physiologic reflex phenomenon. Sneezing has exerted a strange fascination on humans throughout history, and induced sneezing was widely used by physicians for therapeutic purposes, on the assumption that sneezing eliminates noxious factors from the body, mainly from the head. The present contribution examines the various mixtures used for inducing sneezes (remedia sternutatoria) over the centuries. The majority of the constituents of the sneeze-inducing remedies are modulators of transient receptor potential (TRP) channels. The TRP channel superfamily consists of large heterogeneous groups of channels that play numerous physiological roles such as thermosensation, chemosensation, osmosensation and mechanosensation. Sneezing is associated with the activation of the wasabi receptor, (TRPA1), typical ligand is allyl isothiocyanate and the hot chili pepper receptor, (TRPV1), typical agonist is capsaicin, in the vagal sensory nerve terminals, activated by noxious stimulants. -
Euphorbia Subg
ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ НАУКИ БОТАНИЧЕСКИЙ ИНСТИТУТ ИМ. В.Л. КОМАРОВА РОССИЙСКОЙ АКАДЕМИИ НАУК На правах рукописи Гельтман Дмитрий Викторович ПОДРОД ESULA РОДА EUPHORBIA (EUPHORBIACEAE): СИСТЕМА, ФИЛОГЕНИЯ, ГЕОГРАФИЧЕСКИЙ АНАЛИЗ 03.02.01 — ботаника ДИССЕРТАЦИЯ на соискание ученой степени доктора биологических наук САНКТ-ПЕТЕРБУРГ 2015 2 Оглавление Введение ......................................................................................................................................... 3 Глава 1. Род Euphorbia и основные проблемы его систематики ......................................... 9 1.1. Общая характеристика и систематическое положение .......................................... 9 1.2. Краткая история таксономического изучения и формирования системы рода ... 10 1.3. Основные проблемы систематики рода Euphorbia и его подрода Esula на рубеже XX–XXI вв. и пути их решения ..................................................................................... 15 Глава 2. Материал и методы исследования ........................................................................... 17 Глава 3. Построение системы подрода Esula рода Euphorbia на основе молекулярно- филогенетического подхода ...................................................................................................... 24 3.1. Краткая история молекулярно-филогенетического изучения рода Euphorbia и его подрода Esula ......................................................................................................... 24 3.2. Результаты молекулярно-филогенетического -
102 the Effects of Intravesical
102 Harper M, Brady C. M, Scaravilli F, Fowler C. J. Institute of Neurology, London THE EFFECTS OF INTRAVESICAL RESINIFERATOXIN ON SUBUROTHELIAL NERVE DENSITY IN PATIENTS WITH NEUROGENIC DETRUSOR OVERACTIVITY Aims of Study Somatic and autonomic neural pathways integrated in the CNS regulate urine storage and voiding. When spinal cord lesions disrupt these pathways, an aberrant segmental sacral reflex emerges, the afferent limb of which is comprised of small unmyelinated C-fibres that originate in the suburothelium. This pathological reflex is thought to be the underlying cause of “spinal” neurogenic detrusor overactivity (NDO). We are currently evaluating the role of resiniferatoxin (RTX) in the treatment of refractory “spinal” NDO. RTX is an ultra-potent capsaicin analogue purified from the dried latex of the succulent plant Euphorbia Resinifera. The vanillyl group of RTX facilitates the action of the vanilloid receptor (VR-1), a non-selective cation channel expressed on suburothelial C-fibres. Intravesical therapy with a single dose of RTX results in early acute excitatory effects (“sensitisation”) followed by inhibition of neuropeptide release and neuronal terminal field degeneration (“desensitisation”) (Avelino et al., 2001). In patients with refractory NDO, it has been shown that intravesical therapy with vanilloid compounds such as RTX or capsaicin significantly decreases lower urinary tract symptoms for a period of weeks or months, depending on factors such as dose and disease progression. It is thought that the eventual recurrence of symptoms is related to C-fibre regeneration. We have previously shown that the mean suburothelial nerve density decreases in patients who respond to capsaicin. Our experimental aim is to measure suburothelial nerve density in flexible cystoscopic biopsies in controls and patients with NDO before and after intravesical RTX or placebo. -
TRP CHANNELS AS THERAPEUTIC TARGETS TRP CHANNELS AS THERAPEUTIC TARGETS from Basic Science to Clinical Use
TRP CHANNELS AS THERAPEUTIC TARGETS TRP CHANNELS AS THERAPEUTIC TARGETS From Basic Science to Clinical Use Edited by ARPAD SZALLASI MD, PHD Department of Pathology, Monmouth Medical Center, Long Branch, NJ, USA AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Academic Press is an imprint of Elsevier Academic Press is an imprint of Elsevier 125 London Wall, London, EC2Y 5AS, UK 525 B Street, Suite 1800, San Diego, CA 92101-4495, USA 225 Wyman Street, Waltham, MA 02451, USA The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK First published 2015 Copyright © 2015 Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangement with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. -
The Role of Phytotoxic and Antimicrobial Compounds of Euphorbia Gummifera in the Cause and Maintenance of the Fairy Circles of Namibia
The role of phytotoxic and antimicrobial compounds of Euphorbia gummifera in the cause and maintenance of the fairy circles of Namibia by Nicole Galt Submitted in partial fulfillment of the requirements for the degree Magister Scientiae Department of Plant and Soil Sciences Faculty of Natural and Agricultural Sciences University of Pretoria Pretoria Supervisor: Prof. J.J.M. Meyer March 2018 i The role of phytotoxic and antimicrobial compounds of Euphorbia gummifera in the cause and maintenance of the fairy circles of Namibia by Nicole Galt Department of Plant and Soil Sciences Faculty of Natural and Agricultural Sciences University of Pretoria Pretoria Supervisor: Prof. J.J.M. Meyer Degree: MSc Medicinal Plant Science Abstract Fairy circles (FC) are unexplained botanical phenomena of the pro-Namib desert and parts of the West Coast of South Africa. They are defined as circular to oval shaped anomalies of varying sizes that are left bereft of vegetation. Even though there are several distinctly different hypotheses that have aimed to explain the origin of fairy circles, none have done so to satisfaction of the scientific community. The aim of this study was to determine if phytotoxic and antibacterial properties of a co-occurring Euphorbia species, E. gummifera plays a role in the creation of fairy circles. Representative soil samples (from inside-, outside fairy circles and underneath dead E. gummifera plants) and plant samples (aerial ii parts of E. gummifera and intact grasses, Stipagrostis uniplumis) were collected from the area. The collected samples were used for a several biological assays. A soil bed bio-assay was done using the three collected soil types. -
TRPV1 and Endocannabinoids: Emerging Molecular Signals That Modulate Mammalian Vision
Cells 2014, 3, 914-938; doi:10.3390/cells3030914 OPEN ACCESS cells ISSN 2073-4409 www.mdpi.com/journal/cells Review TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision 1,2,†, 1,2,† 1,† 1,2,3,4, Daniel A. Ryskamp *, Sarah Redmon , Andrew O. Jo and David Križaj * 1 Department of Ophthalmology & Visual Sciences, Moran Eye Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA; E-Mails: [email protected] (S.R.); [email protected] (A.O.J.) 2 Interdepartmental Program in Neuroscience, University of Utah School of Medicine, Salt Lake City, UT 84132, USA 3 Department of Neurobiology & Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA 4 Center for Translational Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA † Those authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: [email protected] (D.A.R.); [email protected] (D.K.); Tel.: +1-801-213-2777 (D.K.); Fax: +1-801-587-8314 (D.K.). Received: 1 July 2014; in revised form: 27 August 2014 / Accepted: 5 September 2014 / Published: 12 September 2014 Abstract: Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the modulation of blood flow and osmoregulation but also neurotransmission, postsynaptic neuronal excitability and synaptic plasticity within the central nervous system. -
Plethora of Plants - Collections of the Botanical Garden, Faculty of Science, University of Zagreb (2): Glasshouse Succulents
NAT. CROAT. VOL. 27 No 2 407-420* ZAGREB December 31, 2018 professional paper/stručni članak – museum collections/muzejske zbirke DOI 10.20302/NC.2018.27.28 PLETHORA OF PLANTS - COLLECTIONS OF THE BOTANICAL GARDEN, FACULTY OF SCIENCE, UNIVERSITY OF ZAGREB (2): GLASSHOUSE SUCCULENTS Dubravka Sandev, Darko Mihelj & Sanja Kovačić Botanical Garden, Department of Biology, Faculty of Science, University of Zagreb, Marulićev trg 9a, HR-10000 Zagreb, Croatia (e-mail: [email protected]) Sandev, D., Mihelj, D. & Kovačić, S.: Plethora of plants – collections of the Botanical Garden, Faculty of Science, University of Zagreb (2): Glasshouse succulents. Nat. Croat. Vol. 27, No. 2, 407- 420*, 2018, Zagreb. In this paper, the plant lists of glasshouse succulents grown in the Botanical Garden from 1895 to 2017 are studied. Synonymy, nomenclature and origin of plant material were sorted. The lists of species grown in the last 122 years are constructed in such a way as to show that throughout that period at least 1423 taxa of succulent plants from 254 genera and 17 families inhabited the Garden’s cold glass- house collection. Key words: Zagreb Botanical Garden, Faculty of Science, historic plant collections, succulent col- lection Sandev, D., Mihelj, D. & Kovačić, S.: Obilje bilja – zbirke Botaničkoga vrta Prirodoslovno- matematičkog fakulteta Sveučilišta u Zagrebu (2): Stakleničke mesnatice. Nat. Croat. Vol. 27, No. 2, 407-420*, 2018, Zagreb. U ovom članku sastavljeni su popisi stakleničkih mesnatica uzgajanih u Botaničkom vrtu zagrebačkog Prirodoslovno-matematičkog fakulteta između 1895. i 2017. Uređena je sinonimka i no- menklatura te istraženo podrijetlo biljnog materijala. Rezultati pokazuju kako je tijekom 122 godine kroz zbirku mesnatica hladnog staklenika prošlo najmanje 1423 svojti iz 254 rodova i 17 porodica. -
Euphorbiaceae)
Polish Botanical Journal 60(2): 147–161, 2015 DOI: 10.1515/pbj-2015-0024 PHYTOGEOGRAPHICAL ANALYSIS OF EUPHORBIA SUBGENUS ESULA (EUPHORBIACEAE) Dmitry V. Geltman Abstract. Euphorbia subg. Esula is one of four major clades within the genus. A geographical analysis of the 466 species in the subgenus is reported here. Every species was assigned to one of 29 geographical elements clustered in ten groups of ele- ments. This geographical analysis showed that the Tethyan group (comprising nine geographical elements) clearly dominates the subgenus and contains 260 species (55.79% of the total number of species). The most numerous geographical elements are Irano-Turanian (105 species) and Mediterranean (85). Other significant groups of elements are Boreal (91 species, 19.54%), East Asian (40 species, 8.58%), Madrean (26 species, 5.58%), Paleotropical (23 species, 4.94%) and South African (16 species, 3.43%). The area of the Tethyan floristic subkingdom is the center of the modern diversity of E. subg. Esula. It is likely that such diversity is the result of intensive speciation that took place during the Eocene–Miocene. Key words: Euphorbia subg. Esula, geographical elements, Irano-Turanian floristic region, Mediterranean floristic region, phytogeographical analysis, Tethyan floristic subkingdom Dmitry V. Geltman, Komarov Botanical Institute of the Russian Academy of Sciences, Prof. Popov Street, 2, St. Petersburg, 197376, Russia; e-mail: [email protected] Introduction genus euphorbia and its taxonomy cantly differ from traditional ones. For subgenus Esula (Riina et al. 2013), 21 sections were ac- The giant genus Euphorbia L. (Euphorbiaceae) re- cepted on the basis of analyses of the combined cently became a subject of detailed phylogenetic and ITS + ndhF dataset (Fig. -
PC18 Inf. 6 (English Only / Únicamente En Inglés / Seulement En Anglais)
PC18 Inf. 6 (English only / Únicamente en inglés / Seulement en anglais) CONVENTION ON INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD FAUNA AND FLORA ____________ Eighteenth meeting of the Plants Committee Buenos Aires (Argentina), 17-21 March 2009 TRADE SURVEY STUDY ON SUCCULENT EUPHORBIA SPECIES PROTECTED BY CITES AND USED AS COSMETIC, FOOD AND MEDICINE, WITH SPECIAL FOCUS ON CANDELILLA WAX The attached document has been submitted by the Scientific Authority of Germany*. * The geographical designations employed in this document do not imply the expression of any opinion whatsoever on the part of the CITES Secretariat or the United Nations Environment Programme concerning the legal status of any country, territory, or area, or concerning the delimitation of its frontiers or boundaries. The responsibility for the contents of the document rests exclusively with its author. PC18 Inf. 6 – p. 1 Trade survey study on succulent Euphorbia species protected by CITES and used as cosmetic, food and medicine, with special focus on Candelilla wax Dr. Ernst Schneider PhytoConsulting, D-84163 Marklkofen Commissioned by Bundesamt für Naturschutz CITES Scientific Authority, Germany February 2009 Content SUMMARY ................................................................................................................. 4 OBJECTIVE................................................................................................................ 5 CANDELILLA WAX, ITS USE AND THE PLANT SOURCE ....................................... 6 Candelilla wax -
Espécies Úteis Da Família Euphorbiaceae No Brasil
ARTÍCULO DE REVISIÓN Espécies úteis da família Euphorbiaceae no Brasil Especies de interés de familia Euphorbiaceae en Brasil Species from the Euphorbiaceae family used for medicinal purposes in Brazil MSc. Maria José de Sousa Trindade, Dr. Osmar Alves Lameira Laboratório de Biotecnologia, Embrapa Amazônia Oriental. Belém-PA, Brasil. RESUMO Introdução: Euphorbiaceae está entre uma das maiores famílias botânicas, complexas e diversas. Oferece grande potencial de aproveitamento, com mais de 1 100 espécies, nativas ou aclimatadas no Brasil. As espécies de Euphorbiaceae têm grande destaque na atividade econômica, através da alimentação humana e na medicina a partir do conhecimento popular. Objetivo: aumentar o conhecimento sobre os usos atribuídos as espécies da família, visando contribuir para um melhor emprego das espécies. Métodos: a partir de revisão bibliográfica foram pesquisados livros, sites e artigos científicos, considerando o uso atribuído as espécies da família Euphorbiaceae, no período de 1824 a 2012. Resultados: obteve-se dados relativos a 149 espécies, distribuídas em 35 gêneros com vários usos, a maioria com potencial medicinal. O gênero com maior número de espécies com indicação de uso foi Croton com 58, seguido de Euphorbia com 13 e Jatropha com nove. Conclusão: os estudos expostos apontam para uma grande viabilidade no que diz respeito à utilização das espécies da família. Palavras-chave: botânica econômica, medicina popular, usos, Croton. RESUMEN Introducción: Euphorbiaceae se encuentra entre una de las familias botánicas más grandes, complejas y diversas. Ofrece un gran potencial para su uso, con más de 1 100 especies, nativas o naturalizadas en Brasil. Las especies de Euphorbiaceae tienen gran importancia en la actividad económica, a través de alimentos y medicinas a partir del conocimiento popular. -
Flora of Bokor National Park, Cambodia IV: a New Section and Species of Euphorbia Subgenus Euphorbia
ISSN 1346-7565 Acta Phytotax. Geobot. 67 (2): 83–96 (2016) doi: 10.18942/apg.201518 Flora of Bokor National Park, Cambodia IV: A New Section and Species of Euphorbia Subgenus Euphorbia 1,* 1 2 HIRONORI TOYAMA , SHUICHIRO TAGANE , PHOURIN ChhANG , 3 1 HIDETOshI NAGAMASU AND TEtsUKAZU YAHARA 1Center for Asian Conservation Ecology, Kyushu University, 744 Motooka, Fukuoka 819-0395, Japan. * [email protected] (author for correspondence); 2 Institute of Forest and Wildlife Research and Development, Forestry Administration, 40 Preah Norodom Blvd, Phnom Penh, Cambodia; 3 The Kyoto University Museum, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan A new section, Euphorbia sect. Bokorenses under subgenus Euphorbia is established for Euphorbia bo- korensis H. Toyama & Tagane, sp. nov., endemic to Bokor National Park, Cambodia. Euphorbia sect. Bokorenses is distinguished from related sections Denisophorbia and Goniostema by unbranched stems and smooth seeds, respectively. Bayesian phylogeny using matK, ndhF, and ITS regions supports its monophyly from the currently recognized 21 sections. It has a sister relationship with the Malagasy clade, including sections Denisophorbia, Deuterocalli and Goniostema, and to the northeastern African clade, including sect. Rubellae. A description, illustration, photographs and preliminary conservation status of the new species, and an updated identification key to the sections ofEuphoria subg. Euphorbia is provided. Key words: Bokor National Park, Cambodia, Euphorbia, new section, new species Euphorbia subg. Euphorbia (Euphorbiaceae) in E. subg. Euphorbia. Euphorbia sect. Euphor- exhibits the greatest diversity among subgenera bia is the largest clade in E. subg. Euphorbia hav- in both species richness and growth forms (Horn ing over 340 species extending from Africa to et al. -
Manchester State Park - Vascular Plants* Major Vasc
Manchester State Park - Vascular Plants* Major Vasc. Plant Clades, Rare Plant Ranks, & Families/Scientific (Latin) Names/Common Names/ Duration/Habitat Types A Scientific Name (* = non-native) Common Name Life History/Form Habitat FERNS Athyriaceae (Cliff Fern Family) Athyrium filix-femina var. cyclosorum lady fern perennial moist woods, forests Azollaceae (Mosquito Fern Family) Azolla filiculoides mosquito fern "annual"/herbaceous still water surface Blechnaceae (Deer Fern Family) Struthiopteris spicant deer fern perennial moist woods, canyons Dennstaedtiaceae (Bracken Family) Pteridium aquilinum var. pubescens hairy bracken perennial widespread in grassland, scrub Dryopteridaceae (Wood Fern Family) Dryopteris arguta wood fern perennial scrub; forest Polystichum munitum western sword fern perennial damp forests, scrub, along streams Equisetaceae (Horsetail Family) Equisetum arvense common horsetail perennial wet soils near streams, seeps Polypodiaceae (Polypody Family) Polypodium scouleri leather fern perennial damp woods, stream banks GYMNOSPERMS Cupressaceae (Cypress Family) Hesperocyparis macrocarpa* Monterey cypress tree coastal grassland, scrub Pinaceae (Pine Family) Abies grandis grand fir tree scrub, grassland Pinus contorta ssp. contorta shore pine small tree moist grassland swales, scrub Pinus muricata Bishop pine tree grassland, scrub, forest Pinus radiata* Monterey pine tree disturbed sites; grassland Pseudotsuga menziesii Douglas-fir tree scrub, grassland NYMPHAEALES Nymphaeaceae Nuphar luteum ssp. polysepalum western pond