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RIKEN Bioresource Center Brochure

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RIKEN Bioresource Center Brochure RIKEN TSUKUBA BRANCH RIKEN BioResource Research Center July, 2020 Contents ●Greetings…………………………………… 3 ●Overview of the RIKEN BRC……………… 5 For Trust, Sustainability and Leadership ！ ●Mouse……………………………………… 7 ●Arabidopsis & Brachypodium……………… 8 ●Cell…………………………………………… 9 ●Gene…………………………………………10 ●Microbe……………………………………… 11 ●Laboratories………………………………12 ●History, Budget, Personnel, Facilities ……15 ●Organization…………………………………16 ●Activities of RIKEN BRC……………………17 ●NBRP (National Bioresource Project) ……18 not only to researchers in academia but also to those in the private sector, with large-scale facilities and equipment such as supercomputers Hiroshi Matsumoto, Ph.D and the SPring-8 synchrotron facility, as well Toshihiko Shiroishi, Ph.D President as bioresources. In this regard, the RIKEN Director RIKEN BioResource Research Center (BRC) has long RIKEN BioResource Rresearch Center served as one of RIKEN’s core infrastructure At present, numerous new bioresources are centers. being developed in a wide range of fields of the RIKEN celebrated its centennial on March 20, Finally, precisely because RIKEN is not Bioresources are essential experimental life science, with the advances in genome science 2017. The current year of 2018 marks another limited to any specific one research field, our third materials for researches in life science and and the emergence of innovative genome editing milestone, the 60th anniversary of RIKEN’s strategy is to pioneer new research fields. One innovation based on the life science. In January technologies. These are experimental animal becoming a public corporation and national approach has been to create a Pioneering Research 2001, RIKEN established the BioResource models for senescence and rare or intractable institute in 1958, after going through periods Cluster that represents a modern adaptation of Center (BRC) at the Tsukuba Research Institute diseases in humans, cell lines containing in which it was a private foundation and then a the Chief Scientist system to foster free thinking as a core base for the bioresource infrastructure pluripotent stem cells such as disease-specific private company. and innovative ideas initiated by RIKEN’s third in Japan. Since its establishment, RIKEN BRC iPS cells, plants and microorganisms that are The Act on RIKEN, National Research President Masatoshi Okochi. has been focusing on the major bioresources; indispensable for increasing food production and and Development Institute (Act No. 160, Dec In addition to these three strategies, i.e., experimental mouse strains, model plants, for solving environmental problems and health/ 2002) states that as a national R&D institute, RIKEN is actively engaged in “co-creation” cell lines of human and animal origin, genetic medical care. They also include genetic (DNA) “RIKEN aims to raise the standard of science and “collaboration” activities with domestic materials, as well as relevant information materials derived from the aforementioned and technology by comprehensively carrying universities, industry, and research institutes for associated with these bioresources. In 2005, bioresources. There is also a growing need for out experiments, researches and other operations the purpose of finding solutions for global issues microorganisms have been included in the bioresources with multiple gene mutations in related to science and technology.” and implementing them in socoety. RIKEN plays repositories. RIKEN BRC has been mainly addition to single gene mutation. Under such RIKEN has consistently maintained this a major role as a hub for science and technology collecting bioresources originally developed in circumstance, we anticipate that secondary objective throughout its transitions from public innovation. Dr. Kotaro Honda, a former RIKEN Japan, so as to become a unique facility serving bioresources newly developed by research corporation to independent administrative Chief Scientist, once said “Industry is the practice the world, by support of Japanese government, community using resources provided by the institution, and now, national research and field of learning,” but improving the standard of RIKEN and especially research community. bioresource centers will increase in the future. development institute. RIKEN is the only science and technology cannot be achieved solely Therefore, we think that the important mission of national organization charged with conducting by publishing scientific papers. RIKEN’s objective Today, RIKEN BRC has grown up to be one the bioresource centers is to drive the circulation comprehensive research in all areas of science is to work for “science in society and science for of the three major repositories for each bioresource of bioresources between the bioresource centers and technology rather than just one specific field. society” in cooperation with industry and local in the world. In these years, we have provided and the research community to stimulate the What should RIKEN do to carry out its mission? communities. With this in mind, RIKEN BRC is 15,000 items annually, over 260,000 items life science and innovation. RIKEN BRC will Our present answer is to flexibly implement the working to expand its activities with a satellite since the start of our operation to approximately strive to continue contributing to promotion of following three strategies for improving science facility in Keihanna Science City. 7,200 domestic institutions and 5,500 overseas the life science and industry by collection and and technology. RIKEN’s management policies are outlined institutions in 71 countries. In addition to these dissemination of the cutting-edge resources newly The first is a strategy for “strategic centers” to in the RIKEN Initiative for Scientific Excellence operations, we are engaged in Key Technology developed by the research community. promote the government’s millennium projects, and form the key pillars of RIKEN’s fourth mid- Development Program for effective and efficient ongoing since the start of the 2000s, to achieve to long-term plan. We greatly appreciate your preservation of bioresources that ever increases RIKEN’s fourth mid- to long-term plan, which cutting-edge outcomes through subject-oriented understanding of our various activities and ask in number as well as in Bioresource Frontier started in April 2018, has entered its third year research. for your continued guidance and support as we Program for charactering bioresources and since April 2020. In 2019, RIKEN BRC received The second strategy is for “infrastructure strive to achieve our mutual goal of growth and developing novel bioresources that meet the social invaluable advices and recommendations from the centers” to provide a wide range of supports achievement. and research need. In April 2018, the name of the Domestic Resource Committees, the Domestic center was changed to the BioResource Research Review Committees, the International Advisory RIKEN Initiative for Scientific Excellence Center (abbreviated to BRC as it was before), Council of RIKEN BRC, and finally RIKEN and RIKEN BRC has further strengthened R&D Advisory Council. RIKEN BRC will incorporate Fulfilling RIKEN’s mission to generate world-class results to promote development of bioresources and to these valuable advices and recommendations into enhance their utilization. In this way, foresight and our operation. In April 2020, Dr. Yoshihiro Miwa outstanding leadership of Dr. Kazuo Moriwaki, 1. Pioneer a research management model for maximizing research and development results was appointed as Head of Gene Engineering the founding director, and Dr. Yuichi Obata, the 2. Lead the world in achieving new research and development results through scientific excellence Division. With the new colleague, RIKEN BRC second director, and the unremitting efforts of all will work to further upgrade the world's top- 3. Become a hub for science and technology innovation the staff, have made RIKEN BRC well recognized level bioresource infrastructure with three mottos, 4. Serve as a focal point for global brain circulation bioresource center worldwide. “trust”, “sustainability”, and “leadership”. We 5. Foster the development of world-class leaders in scientific research look forward to your continuous support for our operation. 3 RIKEN BioResource Research Center RIKEN BioResource Research Center 4 BioResource Research Center BioResource The Fourth Mid- to Long-Term Plan of RIKEN BRC Collect, preserve and provide bioresources of the world first class with regard to usability, associated information and quality by grasping social and research needs (I), develop basic technologies for preservation and usage of bioresources (II), conduct research and development that promote active use of our bioresources (III). By all these activities, we aim to contribute to the effective and efficient promotion of cutting-edge research and innovation and to solution of social problems The Plans I. Bioresource Infrastructure：Collect, preserve and provide cutting-edge Experimental Animal (mouse):Animal models Genetic Materials：Learn from living things for understanding of sophisticated life and use their power phenomena, promoting human health and R&D： Vectors with tissue-specific makers conquering diseases R&D：Genome-edited KO and KI mice Microorganisms：Promotion of researches on Experimental Plant： Maximizing the power of health and environment plants R&D： Isolation, identification and R&D：Stress response characterization of microbes involved in symbiosis Integrated Bioresource Information：No Cell Lines：From
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