RIKEN TSUKUBA BRANCH
RIKEN BioResource Research Center
July, 2020 Contents
●Greetings…………………………………… 3 ●Overview of the RIKEN BRC……………… 5 For Trust, Sustainability and Leadership ！ ●Mouse……………………………………… 7 ●Arabidopsis & Brachypodium……………… 8 ●Cell…………………………………………… 9 ●Gene…………………………………………10 ●Microbe……………………………………… 11 ●Laboratories………………………………12 ●History, Budget, Personnel, Facilities ……15 ●Organization…………………………………16 ●Activities of RIKEN BRC……………………17 ●NBRP (National Bioresource Project) ……18 not only to researchers in academia but also to those in the private sector, with large-scale facilities and equipment such as supercomputers Hiroshi Matsumoto, Ph.D and the SPring-8 synchrotron facility, as well Toshihiko Shiroishi, Ph.D President as bioresources. In this regard, the RIKEN Director RIKEN BioResource Research Center (BRC) has long RIKEN BioResource Rresearch Center served as one of RIKEN’s core infrastructure At present, numerous new bioresources are centers. being developed in a wide range of fields of the RIKEN celebrated its centennial on March 20, Finally, precisely because RIKEN is not Bioresources are essential experimental life science, with the advances in genome science 2017. The current year of 2018 marks another limited to any specific one research field, our third materials for researches in life science and and the emergence of innovative genome editing milestone, the 60th anniversary of RIKEN’s strategy is to pioneer new research fields. One innovation based on the life science. In January technologies. These are experimental animal becoming a public corporation and national approach has been to create a Pioneering Research 2001, RIKEN established the BioResource models for senescence and rare or intractable institute in 1958, after going through periods Cluster that represents a modern adaptation of Center (BRC) at the Tsukuba Research Institute diseases in humans, cell lines containing in which it was a private foundation and then a the Chief Scientist system to foster free thinking as a core base for the bioresource infrastructure pluripotent stem cells such as disease-specific private company. and innovative ideas initiated by RIKEN’s third in Japan. Since its establishment, RIKEN BRC iPS cells, plants and microorganisms that are The Act on RIKEN, National Research President Masatoshi Okochi. has been focusing on the major bioresources; indispensable for increasing food production and and Development Institute (Act No. 160, Dec In addition to these three strategies, i.e., experimental mouse strains, model plants, for solving environmental problems and health/ 2002) states that as a national R&D institute, RIKEN is actively engaged in “co-creation” cell lines of human and animal origin, genetic medical care. They also include genetic (DNA) “RIKEN aims to raise the standard of science and “collaboration” activities with domestic materials, as well as relevant information materials derived from the aforementioned and technology by comprehensively carrying universities, industry, and research institutes for associated with these bioresources. In 2005, bioresources. There is also a growing need for out experiments, researches and other operations the purpose of finding solutions for global issues microorganisms have been included in the bioresources with multiple gene mutations in related to science and technology.” and implementing them in socoety. RIKEN plays repositories. RIKEN BRC has been mainly addition to single gene mutation. Under such RIKEN has consistently maintained this a major role as a hub for science and technology collecting bioresources originally developed in circumstance, we anticipate that secondary objective throughout its transitions from public innovation. Dr. Kotaro Honda, a former RIKEN Japan, so as to become a unique facility serving bioresources newly developed by research corporation to independent administrative Chief Scientist, once said “Industry is the practice the world, by support of Japanese government, community using resources provided by the institution, and now, national research and field of learning,” but improving the standard of RIKEN and especially research community. bioresource centers will increase in the future. development institute. RIKEN is the only science and technology cannot be achieved solely Therefore, we think that the important mission of national organization charged with conducting by publishing scientific papers. RIKEN’s objective Today, RIKEN BRC has grown up to be one the bioresource centers is to drive the circulation comprehensive research in all areas of science is to work for “science in society and science for of the three major repositories for each bioresource of bioresources between the bioresource centers and technology rather than just one specific field. society” in cooperation with industry and local in the world. In these years, we have provided and the research community to stimulate the What should RIKEN do to carry out its mission? communities. With this in mind, RIKEN BRC is 15,000 items annually, over 260,000 items life science and innovation. RIKEN BRC will Our present answer is to flexibly implement the working to expand its activities with a satellite since the start of our operation to approximately strive to continue contributing to promotion of following three strategies for improving science facility in Keihanna Science City. 7,200 domestic institutions and 5,500 overseas the life science and industry by collection and and technology. RIKEN’s management policies are outlined institutions in 71 countries. In addition to these dissemination of the cutting-edge resources newly The first is a strategy for “strategic centers” to in the RIKEN Initiative for Scientific Excellence operations, we are engaged in Key Technology developed by the research community. promote the government’s millennium projects, and form the key pillars of RIKEN’s fourth mid- Development Program for effective and efficient ongoing since the start of the 2000s, to achieve to long-term plan. We greatly appreciate your preservation of bioresources that ever increases RIKEN’s fourth mid- to long-term plan, which cutting-edge outcomes through subject-oriented understanding of our various activities and ask in number as well as in Bioresource Frontier started in April 2018, has entered its third year research. for your continued guidance and support as we Program for charactering bioresources and since April 2020. In 2019, RIKEN BRC received The second strategy is for “infrastructure strive to achieve our mutual goal of growth and developing novel bioresources that meet the social invaluable advices and recommendations from the centers” to provide a wide range of supports achievement. and research need. In April 2018, the name of the Domestic Resource Committees, the Domestic center was changed to the BioResource Research Review Committees, the International Advisory RIKEN Initiative for Scientific Excellence Center (abbreviated to BRC as it was before), Council of RIKEN BRC, and finally RIKEN and RIKEN BRC has further strengthened R&D Advisory Council. RIKEN BRC will incorporate Fulfilling RIKEN’s mission to generate world-class results to promote development of bioresources and to these valuable advices and recommendations into enhance their utilization. In this way, foresight and our operation. In April 2020, Dr. Yoshihiro Miwa outstanding leadership of Dr. Kazuo Moriwaki, 1. Pioneer a research management model for maximizing research and development results was appointed as Head of Gene Engineering the founding director, and Dr. Yuichi Obata, the 2. Lead the world in achieving new research and development results through scientific excellence Division. With the new colleague, RIKEN BRC second director, and the unremitting efforts of all will work to further upgrade the world's top- 3. Become a hub for science and technology innovation the staff, have made RIKEN BRC well recognized level bioresource infrastructure with three mottos, 4. Serve as a focal point for global brain circulation bioresource center worldwide. “trust”, “sustainability”, and “leadership”. We 5. Foster the development of world-class leaders in scientific research look forward to your continuous support for our operation.
3 RIKEN BioResource Research Center RIKEN BioResource Research Center 4 BioResource Research Center
The Fourth Mid- to Long-Term Plan of RIKEN BRC Collect, preserve and provide bioresources of the world first class with regard to usability, associated information and quality by grasping social and research needs (I), develop basic technologies for preservation and usage of bioresources (II), conduct research and development that promote active use of our bioresources (III). By all these activities, we aim to contribute to the effective and efficient promotion of cutting-edge research and innovation and to solution of social problems The Plans I. Bioresource Infrastructure：Collect, preserve and provide cutting-edge Experimental Animal (mouse):Animal models Genetic Materials：Learn from living things for understanding of sophisticated life and use their power phenomena, promoting human health and R&D： Vectors with tissue-specific makers conquering diseases R&D：Genome-edited KO and KI mice Microorganisms：Promotion of researches on Experimental Plant： Maximizing the power of health and environment plants R&D： Isolation, identification and R&D：Stress response characterization of microbes involved in symbiosis Integrated Bioresource Information：No Cell Lines：From basic life science research, Information, No Resource clinical research to innovation R&D： Visualize analyzed results of genome R&D： Hematopoietic stem cells information, disease states and images of biological dynamism, and develop novel methods for utilization of bioresources II . Key Technology Development：Develop novel technologies for effective and efficient preservation and quality control of bioresourcesbioresources
Mouse Cloning Using a Drop of Peripheral Blood
III. Bioresource Frontier Program：Conduct bioresource-related R&D to solve social problems Mammalian Genome Dynamics IMPC Phenotyping Pipelines Mouse Phenotype Analysis Young Addition Aged iPSC-based Drug Discovery (Keihanna) adoult tests mice iPS Cell Advanced Characterization Next Generation Human Disease Model 9~19 wks 20~48 wks 49~55 wks Aged models Plant-Microbe Symbiosis Global Network of Bioresources ◆◆研究開発に必要とされるバイオリソースの種類と量は、一国、一機関の収容能力を凌駕Varieties and quantity of bioresources produced and needed have been increasing dramatically and already ◆バイオリソースの質に関する国際標準化が必要exceeded the capacity of a single biological resource center or even single country. Mission ◆Global standardization or harmonization of quality of bioresources is needed. Providing bioresources to life science researchers worldwide ●整備に関する国際協調（国際競争）が必要 ●バイオリソースセンター国際ネットワーク Regenerative Medicine Environmental Issues ●Need for Global Network of Bioresources Stem cell biology R&D for bioenergy production Novel cell therapy Global warming and biodiversity ●General Asian Network of Research Resource Centers (ANRRC) No Resource ●Mouse International Mouse Strain Resource Database (IMSR) No Research （http://www.findmice.org/） International Mouse Phenotyping Consortium (IMPC) Innovative Drug Development Food Production Elucidation of disease mechanisms Stress tolerant crops ●Human and Animal Cells Nutrition rich crops and vegetables Discovery based ongenome information International Stem Cell Bank Initiative (ISCBI) The International Cell Line Authentication Committee (ICLAC) ●Plant Infectious Diseases・ Immunology Basic and Fundamental Research Emerging and reemerging pathogens Essential materials supporting Multinational Arabidopsis Steering Committee (MASC) Brain Science Allergy and autoimmune diseases all fields of life science Cancer Research ●Microbes Holistic understanding of cognition, Advanced and novel methods for World Federation for Culture Collections (WFCC) memory, learning, health, and diseases diagnostic, treatment and prevention
5 RIKEN BioResource Research Center RIKEN BioResource Research Center 6 BioResource Research Center environment preservation For food production and our health and diseases For basic researches to study Arabidopsis Dicot model plant
We distribute mutant Arabidopsis resources that are useful for functional genomics. (Experimental Plant Division)
Mouse We collect, preserve and distribute high- quality mouse resources useful for basic researches to contribute our health.
We develop novel mouse resources and technologies for preservation, distribution and quality control.
We offer training courses for advanced technologies for best use mouse resources.
(Experimental Animal Division and Bioresource Engineering Division)
We distribute resources and technologies of Brachypodium that help crop breeing reseasrch. Monocot model plant Brachypodium 7 RIKEN BioResource Research Center RIKEN BioResource Research Center 8 BioResource Research Center clinical applications From life sciences to how the body works A tool to understand Gene We aim to facilitate life science research for improvement of human welfare and for solution of environmental issues and hope to contribute to the sustainable development of science.
Genetic materials are the most fundamental and essential research tools. They are used in the all fields of the life science, from basic to applied researches.
The time has come to order genetic materials instead of cloning by yourself. You can easily find genes of your needs by on-line search in our web site.
(Gene Engineering Division)
Cell
The cell engineering division is providing a high quality cell lines free of mycoplasma infection and misidentification. In order to contribute not only to basic sciences but also to applied sciences, we are providing various cell materials such as human cancer cell lines, ES cells, iPS cells, and human somatic stem cells.
In addition, we are also offering training courses for the technologies relating to cell culture. (Cell Engineering Division)
999 RIKEN RIKEN BioResource BioResource Center Research Center RIKEN BioResource Research Center 10 BioResource Research Center human healt h For environmental preservation and Laboratories Head
Atsushi YOSHIKI, Ph.D.
Mice ● Collection, preservation, quality-control and distribution of mouse resources useful for basic researches to Microbe understand the higher-order biological phenomena and to conquer human complex diseases. ● Development of novel mouse resources which meet social and research needs and relevant technologies for preservation, distribution and quality control. We are contributing to a wide range of researches ● Contribution to the promotion of life sciences by offering training courses to disseminate advanced technologies from basic to innovation by collecting and for the best use and quality control of mouse resources in collaboration with global mouse repositories. providing diverse authentic type strains and their Head
related strains of microorganisms. Arabidopsis Masatomo KOBAYASHI, Ph.D. Brachypodium distachyon ● Collection, preservation and distribution of Arabidopsis resources that are indispensable for plant science. We hold a number of microbial strains useful for ● Establishment of research infrastructure of Brachypodium distachyon, a model crop that contributes researches for solution of environmental issues innovation in agriculture. such as production of bioenergy, development of ● Development and propagation of plant cultured cells, DNA materials and related technologies that promote studies on the environment, food, and production of useful materials. biodegradable plastics, and bioremediation.
Head These are also strains that are beneficial for Yukio NAKAMURA, M.D., Ph.D. Human and Animal Cells health science such as improvements of enteric ● Collection and distribution of the following cells: cultured cell lines such as human cancer cell lines; condition and immunological competence, antibiotic stem cells such as ES cells, iPS cells (including disease-specific iPS cells) and human somatic stem cells; cells production, and fermented food. for human genome research. ● Accepting donation and deposition of cells that have been developed by life science community, carrying out quality (Microbe Division/Japan Collection control of them, standardizing them, and distributing high quality cell materials to all scientists around the world. of Microorganisms) ● Offering training courses of the technologies relating to cell culture, so as to contribute to the development of new technology such as human ES cells and iPS cells.
Head
DNA Material Yoshihiro MIWA, Ph.D.
● Cutting edge resources that can accelerate researches that contribute to the elucidation of higher-order biological phenomena and the cause of diseases, the development of medical treatment, the drug discovery research and/or the problems in environment: reporter vectors visualizing biological activity, efficient gene transduction and expression vectors. ● Highly useful and convenient resources: variety of standard DNAs extracted from microorganisms, mice and cultured cells and ready-to-use expression vectors. ● Highly reliable biological resources with highest quality: quality tests under rigorous control and abundant literatures and information of biological characteristics.
Head
General Microbes Moriya OHKUMA, Ph.D. ● Preservation and provision of scientifically important microbial strains representing diverse species of Bacteria, Archaea, and Fungi. ● Collection of microbial bioresources that contribute to environmental and health science, enrichment of information of the strains in the database, and development of related technology. ● Provision of reliable high-quality microbial cultures by intensive quality control with genetic and physiological tests and stable preservations.
Integrated Bioresource Information Division Head
Hiroshi MASUYA, Ph.D. ● Collection, analysis, management of bioresource information and its dissemination to research communities through the web-based catalogs. ● Improvement of technologies for sharing and application of bioresouce-related information in the Internet. ● Analysis and visualization of large-scale data to promote expanding uses and values of bioresources and contribution to solving various problems of human beings.
11 RIKEN RIKEN BioResource BioResource Center Research Center RIKEN BioResource Research Center 12 BioResource Research Center
iPS Cell Advanced Support Unit for Quality Management Unit Leader Characterization and Development Team Team Leader Masatomo KOBAYASHI, Ph.D. Uniform international quality standard : ISO 9001 Yohei HAYASHI, Ph.D. ● QMS (Quality Management System) in order for BRC to achieve total customer satisfaction and to deliver the highest value biological resources and services on time. ● Advanced characterization (e.g., pluripotency and genome) of disease-specific iPS cells deposited in RIKEN ● Endeavor to deliver the biological resources of reliable quality. cell bank. ● Maintenance of ISO 9001 certification to deliver the biological resources of reliable quality, and horizontal development ● Development of modified (e.g., mutation-corrected, mutation-introduced, and reporter-introduced) iPS cells using of ISO management system framework. genome-editing technologies. ● Endeavor for customer satisfaction, human resource development and continual improvement, based upon Total Quality ● Development of differentiation system and disease models using disease-specific iPS cells deposited in Management (TQM) which has made Japanese manufacturing industry very strong． RIKEN cell bankcollaborative researches with domestic and international research communities. ● Realization and standardization of high-quality, speedy and simple job process, by means of the data digitization making use of the latest Information Communication Technology (ICT). Team Leader Head Next Generation Human Disease Model Team Takanori AMANO, Ph.D. Atsuo OGURA, D.V.M.,Ph.D.
● Nuclear transfer cloning: Establishment of an efficient technique for production of cloned mice. A great leap ● Development of mouse models faithfully recapitulating genomic mutations and pathology of designated to the practical use of cloning technology in mammals. intractable diseases or diseases of the aged based on the patients’ genome information by the genome ● Microinsemination (sperm injection): Production of normal mice using not only normal mature spermatozoa, modification technology. but also immature spermatids and spermatozoa retrieved from frozen mouse bodies. ● Analyses and evaluation of the mouse models through the standard, disease-specific and ageing-specific ● Cryopreservation of embryos and germ cells and their transportation: Development of embryo phenotyping platforms of the international standard. cryopreservation techniques applicable to a variety of mouse strains. Safe transportation of vitrified embryos ● Establishment of POC in preclinical studies by investigating disease mechanisms and pharmacokinetics in in dry ice packages to avoid the use of dry shippers. collaboration with experts. ● Establishment of new stem cell lines: Mouse ES cells with different characters and different origins. Rabbit ● Provision of disease models with useful information for diagnosis, therapies and drug discovery to biomedical ES cells and iPS cells with potential usefulness as new experimental models. research community. ● Technical training courses: Cryopreservation of mouse sperm and embryos, and establishment and maintenance of mouse embryonic stem cells. Plant-Microbe Symbiosis Research and Team Leader
Yasunori ICHIHASHI, Ph.D. Team Leader Development Team
Kuniya ABE, Ph.D. ● Elucidation of the symbiosis between plants and rhizosphere microbes including mycorrhizal fungi. ● Technology development for functional genomic analysis: methods for high resolution genotyping and ● Construction of bioresources and experimental systems of experimental plants and rhizosphere microbes for the genome manipulation utilizing high quality BAC genomic resources. symbiosis studies. ● Technology development for characterization of embryo-derived stem cells and germ cells: analysis of ● Contribution to building a sustainable solution for world food and environmental problems through molecular and epigenetic features of these cell types using novel imaging techniques and genomic analyses at collaborative researches with domestic and international research communities. single-cell level.
● Technology development for bioimaging: analysis of cellular behaviors and functions in vivo utilizing an iPS Cell Research Unit for Unit Leader intravital microscope equipped with novel stick-type lenses. Drug Discovery (RIKEN DMP) Yukio NAKAMURA, M.D., Ph.D.
Team Leader
Masaru TAMURA, Ph.D. ● This unit belongs to RIKEN Program for Drug Discovery and Medical Technology Platforms (RIKEN DMP). J ap ic an lin Mouse C ● Basic researches using disease-specific iPS cells to identify the causal and/or associated cells of each disease. ● Systematic and comprehensive phenotypic analyses for genetically-modified mice based on the fundamental ● Development of methods to screen chemicals for drug discovery with the causal and/or associated cells and in-depth pipelines in the Japan Mouse Clinic. derived from disease-specific iPS cells. ● Contribution to international mouse phenotyping project through the participation to International Mouse ● Refinement of technologies to induce the causal and/or associated cells efficiently from disease-specific iPS Phenotying Consortium (IMPC). cells, and the mass production of such cells for chemical screening. ● Intellectual infrastructure for the mouse resource through the integration of mouse phenotype information with the related clinical data on human diseases. ● Development of new phenotyping methods to analyze mouse resources.
Laboratory Head
iPSC-based Drug Discovery
G H O LT O A D E F H O Team Leader R R O E F D
D U
O C A
O T
G Ph.D. I
O and Development Team Kazuo SHINOZAKI, N Haruhisa INOUE, M.D., Ph.D.
● ● Leading drug discovery technology that will open a avenue for new medicines. Construction of research infrastructure for the promotion of biomass engineering based on a model biomass plant Brachypodium. ● Using iPS cells of BioResource Center to develop infrastructure technology for drug discovery and medical study. ● ● Bridging RIKEN BRC and academia/industry in the field of translational iPS cell research. Contribution to advanced bioresources on the collection of full-length cDNA and phenotype analysis of gene knock-out mutants in Arabidopsis. ● Engage in the development of drug discovery researches using disease-specific iPS cells of RIKEN BRC cellbank at Keihanna in collaborating with the Cell Engineering Division, and Center for iPS Cell Research ● Discovery of useful genes for the application to molecular breeding of drought tolerant rice, wheat and and Application (CiRA), Kyoto University. soybean.
13 RIKEN BioResource Research Center RIKEN BioResource Research Center 14 BioResource Research Center
Budget（FY2019）
1917 March RIKEN Foundation established. BioResource Center・Tsukuba Branch 1948 March RIKEN Foundation dissolved and replaced by Government subsidy/Operating expenses grant …2.82 billion yen KAKEN (Kagaku Kenkyusho) Corporation 1958 October RIKEN Act enforced. Dissolution of KAKEN Corporation and initiation Competitive external funds…………………0.45 billion yen of the Public Corporation RIKEN. 1974 May Life Science Promotion Division set up to undertake life science projects. 1984 October Tsukuba Life Science Center founded. 1987 May Gene Bank began operation. 2000 April Tsukuba Life Science Center renamed Tsukuba Institute. 2001 January RIKEN BioResource Center founded in Tsukuba Institute. Personnel（April, 2020） 2003 October RIKEN reorganised as Independent Administrative Institution. 2004 July The Japan Collection of Microorganisms (JCM) ● Developmental Research Staffs …………………………… in Discovery Research Institute in the Wako 371 Institute was integrated with the BioResource ● Permanent Researchers ……………………………… 20 Center. ● Indefinite-term Employee …………………………… 13 2008 April The second term as an independent ● Contract Research Staffs …………………………… 44 administrative institution. Functional Genomics Research Group of the ● Technical Staffs …………………………………… 72 RIKEN Genomic Sciences Center was merged ● International Program Associate …………………… 1 to the BioResource Center. 2011 January RIKEN BRC 10th Anniversary ● Junior Research Associate ……………………… 3 2012 October JCM moved to Tsukuba campas. ● Agency Staffs ……………………………………… 46 2013 April The third term as an independent administrative ● Visiting Staffs ……………………………………… 50 institution. 2015 April “Tsukuba Institute” renamed “Tsukuba Branch” ● Student Trainees and Research Fellows………………… 15 RIKEN reorganised as National Research and ● Outsourcing, Part-timers …………………………… 107 Development Institute ● Administrative Employees & Tsukuba Safety Center Staff ………58 2016 October RIKEN reorganised as Designated National Research and Development Institute Total …429 2017 March RIKEN 100th Anniversary 2018 April “BioResource Center” renamed “BioResource Research Center”
15 RIKEN BioResource Research Center RIKEN BioResource Research Center 16 BioResource Research Center
Activities of RIKEN BRC u ic Re tions cti ities
● ur e site ro i es use u in or tion out resources rotoco s s etc ● ont ne s etters e turin Resource o t e ont re istri ute i e i t e i isions ● utre c cti it usin oot is n n outs t n scienti ic eetin s ● is t su u cience In or tion Center Bi i su u ● nnu o en or ener u ic ●E i ition s ce on our re ises or isitors ●BRC ci it tour to cce t ne r i sc oo stu ents in ● series o t o our science ectures or u t citi ens n o er n s on e rnin o ortunities t su u E center
Coo er tion it on si n Countries
● e tten e t e t RIKEN BRC N n in ni ersit RC K C Intern tion ouse or s o n ino Kore ouse or s o in N n in ni ersit RC in su er ● e tten e t e t si n Net or o Rese rc Resource Centers NRRC Intern tion eetin in os B os i i ines in ● e ro i e o ortunities or con uctin rese rc in RIKEN BRC to orei n e t ouse or s o （ su u ） rese rc ers stu ents n interns ro Net er n s e en Russi ri n B n es si In onesi C in n Kore in NBRP(National BioResource Project) ●RIKEN BRC conc u e o it t e Kore n N tion Rese rc Resource Center KNRRC n Institute o icro io o C inese c e o ciences I C in ●RIKEN BRC conc u e Recor o iscussion Ro it t e Bio i ersit B se e e o ent ice BE in B n o in e t NRRC eetin （ os B os i i ines）
General outline and purpose of the project The National BioResource Project (NBRP) was started by the Ministry for Education, Culture, Sports, Science and Technology (MEXT) in 2002 and has been operated by the Japan Agency for Medical Research and Development (AMED) since FY 2015. The aim of NBRP is to collect, preserve and distribute bioresources (such as animals, plants, microbes, cell lines and DNA materials) that are essential materials for life science researches, and to upgrade the bioresources responding to the demands of the present age by enriching values of bioresources through developing preservation technology, genome analysis and others. In addition, NBRP aims to improve the function of the information center which provides whereabouts and characteristics of bioresources.
17 RIKEN BioResource Research Center RIKEN BioResource Research Center 18 RIKEN BioResource Research Center Tsukuba Branch 3-1-1 Koyadai Tsukuba Ibataki 305-0074 Japan FAX +81-29-836-9109 Contact us http://en.brc.riken.jp/index.shtml
https://mus.brc.riken.jp/en/ https://epd.brc.riken.jp/en/ https://cell.brc.riken.jp/en/ https://dna.brc.riken.jp/ https://jcm.brc.riken.jp/en/ Integrated Bioresource Information Division https://info.brc.riken.jp/en/ FAX +81-29-836-9523 https://ja.brc.riken.jp/lab/kougaku/indexE.html Technology and Development Team for Mammalian Genome Dynamics https://ja.brc.riken.jp/lab/mcd/mcd/pg2.html Technology and Development Team for Mouse Phenotype Analysis/Japan Mouse Clinic https://ja.brc.riken.jp/lab/jmc/mouse_clinic/en/index.html iPSC-based Drug Discovery and Development Team https://iddd.brc.riken.jp/en/ iPS Cell Advanced Characterization and Development Team https://acd.brc.riken.jp/en/ Next Generation Human Disease Model Team https://hdm.brc.riken.jp/en/ Plant-Microbe Symbiosis Research and Development Team https://pms.brc.riken.jp/en/ iPS Cell Research Unit for Drug Discovery (RIKEN DMP) http://www.riken.jp/en/research/labs/brc/ips_drug_discov/ http://www.csrs.riken.jp/jp/labs/gdrg/index.html http://rtcweb.rtc.riken.jp/English/index-e.html
RIKEN 2020-048