DOCSLIB.ORG

A Glance at the Tumor Microenvironment In

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
A Glance at the Tumor Microenvironment In Torch January 2021 Issue 22.1 International Waldenstrom’s Macroglobulinemia Foundation INSIDE THIS A GLANCE AT THE TUMOR MICROENVIRONMENT ISSUE IN WALDENSTROM MACROGLOBULINEMIA A Glance at the Tumor By Shahrzad Jalali, PhD Microenvironment in Waldenstrom Macroglobulinemia .... 1 Editor’s note: Dr. Shahrzad Jalali has been a research associate in the Division of Hematology at Mayo Today, Tomorrow, Clinic Rochester since 2015. She received her PhD in and Beyond................ 6 biochemistry and medical genetics from the University of Manitoba, Canada, and obtained her postdoctoral IWMF Leadership trainings from Princess Margaret Cancer Centre and Passes the Torch ....... 8 Hospital for Sick Children, University of Toronto, where she studied malignant brain tumors. She currently Torch Toon .................... 9 works as a research associate within the lymphoma group at Mayo Clinic, and her research is focused on IWMF Funded Research: B-cell lymphomas, with a primary focus on Waldenstrom Progress Report ....... 10 macroglobulinemia (WM). Dr. Jalali is investigating the contribution of the bone marrow microenvironment in IWMF Funded Research: New 2020 Grants ...... 11 WM pathogenesis. She was the recipient of an IWMF-LLS Strategic Research Roadmap grant in 2017, as well as an Dr. Shahrzad Jalali IWMF Young Investigator Award in 2016 and 2018. The An Important New Career Development results of her work in WM have appeared as peer-reviewed articles in the past five years, Program for Young and her contribution to the field is ongoing. Investigators ............. 13 The human immune system is composed of a wide variety of cell types, including B-cells, Navigating My Life with T-cells, mast cells, neutrophils, macrophages, and monocytes. While the functions of all these Waldenstrom’s ..........14 cell types are necessary to maintain the equilibrium of the immune system, B-cells are central to humoral immunity, which is the part of the immune system that combats invading pathogens Medical News by producing and secreting antigen-specific immunoglobulins (Ig), also called antibodies. Roundup ................... 15 B-cells originate from immature cells called multipotent hematopoietic stem cells and common How You Can Get lymphoid progenitor cells in the bone marrow and undergo the steps of maturation to express Involved in WM immunoglobulins of different classes (IgM and IgD) on their cell surface; then they leave the Research .................. 20 bone marrow to enter secondary or peripheral lymphoid tissues, such as the lymph nodes and Australian Michael Van spleen. In the peripheral tissues, B-cells complete their development and eventually become Ewijk Rides 702 Km specialized plasma cells that secrete large amounts of the same type of antibodies found on their for a Fundraiser ........ 24 cell surfaces (Figure 1). During this process, B-cells that recognize self-antigens are removed, a process called negative selection, in order to protect one’s own body tissues from the effects Remembering Cindy Lou Furst ........ 25 of B-cell-specific autoimmune responses. Understanding the detailed molecular events that control the differentiation of normal B-cells Support has been instrumental in helping to identify the origin of Waldenstrom macroglobulinemia Group News ............. 26 (WM), which is a low-grade B-cell lymphoma. The pathogenesis of WM is due to the International Scene .... 28 infiltration and growth of malignant B-cells, primarily referred as lymphoplasmacytic lymphoma cells, within the bone marrow where they live, proliferate, and secrete large From IWMF Connect: amounts of immunoglobulin class M (IgM), thereby disrupting the equilibrium of the bone Winter 2021 .............. 32 marrow. A Glance, cont. on page 3 FOUNDER OFFICE & PROJECT MANAGER, INFORMATION Arnold Smokler MANAGER & SUPPORT PRESIDENT EMERITA Donna Cutillo Michelle Postek Judith May DIRECTOR, DEVELOPMENT & MANAGER, MEETINGS & PRESIDENT EMERITUS COMMUNICATIONS PARTNER ENGAGEMENT Carl Harrington Jeremy Dictor Sara McKinnie PRESIDENT & CEO Newton Guerin CHAIR OF THE BOARD IWMF SCIENTIFIC ADVISORY COMMITTEE Peter DeNardis Stephen Ansell, MD, Co-Chair Efstathios Kastritis, MD Mayo Clinic University of Athens, School of Medicine SECRETARY-TREASURER Steven Treon, MD, Co-Chair Beverly Docteur Dana-Farber Cancer Institute Eva Kimby, MD Karolinska Institute, Sweden VICE CHAIRS James R. Berenson, MD Institute for Myeloma & Véronique Leblond, MD Tom Hoffmann, MD Hôpital Pitié Salpêtrière, France Michael Sesnowitz Bone Cancer Research Lisa Wise Christian Buske, MD Monique Minnema, MD University Ulm, Germany UMC Utrecht, Netherlands BOARD OF TRUSTEES Jorge Castillo, MD Gwen Nichols, MD Stephen Ansell, MD Dana-Farber Cancer Institute Leukemia & Lymphoma Society Ron Branscome Glenn Cantor Morton Coleman, MD Roger Owen, MD Shirley Ganse Weill Cornell Medical College St. James’s Institute of Oncology, United Kingdom Paul Kitchen Meletios A. Dimopoulos, MD Carl Lisman School of Medicine Lia Palomba, MD Meg Mangin University of Athens, Greece Memorial Sloan Kettering Linda Nelson Cancer Center Stanley Frankel, MD BOARD ADVISOR Columbia University Surinder Sahota, PhD Steven Treon, MD University of Southampton, Morie Gertz, MD United Kingdom Mayo Clinic FINANCE MANAGER Sheeba Thomas, MD Robin Tucker Irene Ghobrial, MD MD Anderson Cancer Center Dana-Farber Cancer Institute Brian Van Ness, PhD DIGITAL & CREATIVE Zachary Hunter, PhD University of Minnesota SERVICES MANAGER Dana-Farber Cancer Institute Maureen Baeck The IWMF Torch is a publication of IWMF. This publication is designed to provide information about the disease Waldenstrom’s macroglobulinemia. It is distributed as a member service by the International Waldenstrom’s Macroglobulinemia Foundation, Inc., to those who seek information on Waldenstrom’s macroglobulinemia with the understanding that the Foundation is not engaged in rendering medical advice or other professional medical services. EDITOR IWMF CONNECT FORMATTING & Shirley Ganse Jacob Weintraub, MD PRODUCTION ASSOCIATE EDITOR INTERNATIONAL Sara McKinnie Sue Herms CORRESPONDENT TORCH ADVISOR 6144 Clark Center Avenue SUPPORT GROUP NEWS Annette Aburdene Peter DeNardis Sarasota, FL 34238 Chris Stay CARTOONIST Telephone 941-927-4963 SCIENCE EDITOR Linda Pochmerski Fax 941-927-4467 Glenn Cantor E-mail: [email protected] IWMF is a 501(c)(3) tax exempt non-profit organization Fed ID #54-1784426. Waldenstrom's macroglobulinemia Website: www.iwmf.com is coded 273.3 in the International Classification of Diseases (ICD) of the World Health Organization. A Glance, cont. from page 1 Recent studies have shown that the malignant B-cells of microenvironment. They have shown that there is a protein WM are unable to go through the process called class factor, called chemokine stromal derived factor-1 (SDF-1), switch recombination, during which proliferating B-cells which is highly expressed in the bone marrow of WM switch the expression of one class of immunoglobulins to patients. The receptor for this factor, called CXCR4, is another when encountering foreign antigens. An example found on the surface of WM cells. The interaction between would be switching from IgM class to IgG or IgA class. SDF-1 and CXCR4 mediates migration of the WM cells out of the blood vessels. Indeed, approximately 30% of The bone marrow niche WM patients have elevated levels of CXCR4 molecules As a main location for the infiltration and proliferation of on the surface of their WM cells, due to its altered genetic malignant B-cells, the bone marrow microenvironment structure. This increased CXCR4 expression, together with plays a key role in the pathogenesis of WM. The architecture an increase in SDF-1 level, could increase the CXCR4/ of the bone marrow is composed of both cellular and non- SDF-1 interaction and the homing of WM cells in the bone cellular compartments. The cellular compartments of the marrow. Increased survival of WM cells also impacts their bone marrow contain blood cells and their precursors migration and homing in the bone marrow. (such as B-cells, T-cells, neutrophils, monocytes, and red blood cells), as well as non-blood cells (including cells The role of non-cellular/soluble factors of the bone that produce fat, bone, and blood vessel tissues). The marrow in WM non-cellular components of the bone marrow involve Cytokines and chemokines are among the non-cellular extracellular matrix, cytokines, chemokines, growth soluble factors of the bone marrow and act as messenger factors, and metabolites. Indeed, there is a complex, yet molecules that bind to their receptors on cell surfaces and harmonized, array of interactions between cellular and regulate signaling cascades within the cells. Cytokines non-cellular components of the bone marrow that not only regulate differentiation of B-cells into plasma cells and controls continued existence of the hematopoietic stem facilitate plasma cell equilibrium and immunoglobulin and progenitor cells, but also determines their ability to secretion in the bone marrow. For instance, interleukin-21 generate different blood cells under normal and healthy (IL-21) is a cytokine known to regulate normal B-cell conditions. Here we highlight some of the findings related function and B-cell differentiation into immunoglobulin- to the mechanism by which WM cells home to the bone producing plasma cells. B-cell activating factor (BAFF), marrow as well as the contribution of both cellular and non- also called B-lymphocyte stimulator (BLyS), is another cellular factors
Load more

Recommended publications
  • Alphabetical Price List April 2020 SKU SKU Description Status Retail Whl
    Alphabetical Price List April 2020 SKU SKU Description Status Retail Whl Break 1 Break 1 Break 2 Break 2 Break 3 Break 3 Break 4 Break 4 10003 10003-Emb NYLT A 4.99 3.29 12 2.99 48 2.79 0 0 0 0 100 100-Applique Embd FDL 4pk A 2.99 2.24 12 1.99 48 1.59 0 0 0 0 1013 1013-Giftcard TrailsEndPrgrm 013 N 13 11.05 0 0 0 0 0 0 0 0 101 101-Pin FDL Silvertone 5/8"@ A 3.99 2.99 24 2.79 0 0 0 0 0 0 10202 10202-Emb Ptrl Antelope A 2.49 1.79 12 1.69 300 1.29 0 0 0 0 10206 10206-Emb Ptrl Beaver A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10209 10209-Emb Ptrl Bobwhite A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10211 10211-Emb Ptrl Dragon A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10212 10212-Emb Ptrl Eagle A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10213 10213-Emb Ptrl Flaming Arrow A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10215 10215-Emb Ptrl Fox A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10221 10221-Emb Ptrl Lightning A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10223 10223-Emb Ptrl Owl A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10226 10226-Emb Ptrl Pheasant N 0.39 0.39 0 0 0 0 0 0 0 0 1022 1022-Giftcard TrailsEndPrgrm 022 N 22 18.7 0 0 0 0 0 0 0 0 10230 10230-Emb Ptrl Rattlesnake A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10233 10233-Emb Ptrl Scorpion A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10234 10234-Emb Ptrl Shark A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10237 10237-Emb Ptrl Viking A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10239 10239-Emb Ptrl Wolf A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10240 10240-Emb Ptrl Blnk A 2.49 1.89 12 1.69 48 1.29 0 0 0 0 10302 10302-Emb Merit Camping A 2.79 2.39 12 2.19 144 1.89 0 0 0 0 10303 10303-Emb
    [Show full text]
  • TERRAIN INTELLIGENCE Ifope~}M' Oy QUARTERMASTER SCHOOL Lubflar
    MHI tI"Copy ? ·_aI i-,I C'opy 31 77 /; DEPARTMENT OF 'THE ARMY FIELD MANUAL TERRAIN INTELLIGENCE IfOPE~}m' Oy QUARTERMASTER SCHOOL LUBflAR. U.S. ARMY QUA. TZ. MSIR SCL, FORT LEE, VA. 22YOlS ,O.ISTx L.at. : , .S, HEAD QU ARTER S, DEPARTMENT OF T HE ARMY OCTOBER 1967 *FM 30-10 FIELD MANUAL HEADQUARTERS DEPARTMENT OF THE ARMY No. 30-10 I WASHINGTON, D.C., 24 October 1967 TERRAIN INTELLIGENCE CHAPTER 1. INTRODUCTION ..........................-- 1-3 2. CONCEPTS AND RESPONSIBILITIES Section I. Nature of terrain intelligence _____.______ .__. 4-7 II. Responsibilities -. ------------------- 8-11 CHAPTER 3. PRODUCTION OF TERRAIN INTELLIGENCE Section I. Intelligence cycle __ …...__…____-----__-- 12-16 II. Sources and agencies ….................... .--- 17-23 CHAPTER 4. WEATHER AND CLIMATE Section I. Weather ..................................... 24-39 II. Climate -.................................. 40-47 III. Operations in extreme climates _................. 48-50 CHAPTER 5. NATURAL TERRAIN FEATURES Section I. Significance .................................. 51, 52 II. Landforms __________ _------------- ------- 53-61 Drainage............................. 62-69 IV. Nearshore oceanography ................. 70-75 V. Surface materials ............................ 76-81 VI. Vegetation ................................... 82-91 CHAPTER 6. MANMADE TERRAIN FEATURES Section I. Significance -.............................. 92, 93 II. Lines of communication ….................... 94-103 III. Petroleum and natural gas ____. _._______.___ 104-108 IV. Mines, quarries, and pits ….................... 109-112 V. Airfields ----------------------------- 113-115 VI. Water terminals _______…-------- ----------- 116-118 VII. Hydraulic structures -........................ 119-121 VIII. Urban areas and buildings ................... 122-128 IX. Nonurban areas ___ _--------------------- 129-131 CHAPTER 7. MILITARY ASPECTS OF THE TERRAIN Section I. Military use of terrain _....._________._____._ 132-139 Ii. Special operations ......................... 140, 141 III.
    [Show full text]
  • IJA Enewsletter Editor Don Lewis (Email: [email protected]) Renew at Http
    THE INTERNATIONAL JUGGLERSʼ ASSOCIATION December 2011 IJA eNewsletter editor Don Lewis (email: [email protected]) Renew at http:www.juggle.org/renew IJA eNewsletter Contents: Happy Holidays IJA eZine ! Teaching the Cascade Recycling - Build Green Clubs Stagecraft Corner 2011 Festival Video AMS System Update Rain Ending... an 8 year run 7 Doigts on Time Top 10 List Rola Bola 2 Feeding the Inner Juggler Turbo Fest 2012 Regional Festivals Best Catches Juggling Festivals: Waidhofen, Austria Quebec, QC, Canada North Goa, India Seattle, WA Madison, WI Sydney, Australia Atlanta, GA The holiday cartoon above originally appeared in Heerien, Netherlands the November 1979 IJA newsletter. Regardless St. Paul, MN of what holiday youʼre celebrating this season, Austin, TX have a happy and safe one. Don Lewis, Editor Bath, UK Arcata, CA Bali, Indonesia Southend on Sea, UK Winston-Salem, NC IJA Festival 2012 Marion, IN Winston-Salem, NC July 16 - 22, 2012 Save the dates! WWW.JUGGLE.ORG Page 1 THE INTERNATIONAL JUGGLERSʼ ASSOCIATION December 2011 eZine ? Coming January 1, 2012 http://ezine.juggle.org Celebrate the New Year with the IJAʼs new eZine! WWW.JUGGLE.ORG Page 2 THE INTERNATIONAL JUGGLERSʼ ASSOCIATION December 2011 Teaching the Cascade, by Don Lewis Hereʼs the scenario: You go to a seasonal party at a stem from anxiety - trying to go too fast. Just stand in friend or relativeʼs place. Perhaps you only see them front and do two throws as slow as you can. Get them to once a year. Someone will have received a set of juggling copy you. This rarely takes more than a couple of balls as a gift, which are sitting unused because they keep minutes.
    [Show full text]
  • Flying Disc Illustrated V1n4 Summer84contributor
    ‘“j£“j“‘ 11111‘T‘ CHAMPION DISCS INC. KEH PERFORMANCE DEPENDABLE UNBREAKABLE EASY TO THRGN P. D.G.A. APPROVED These Terms combined cdn only describe one compony’s flying discs, iNNOVA””— CHAMPION DISCS INC. We are The folkswho brought you The AERO ond The AV|AR”‘flying discs. We hope you enjoy them. TM INNOVA"”—CHAMP|ONDISCS, INC. FILE?HN@ 1IDH@@ flll IIPHIITI FDI has decided to expand the scope of its coverage. As a result of strong support we have received from around the world, we have so much material to print, that it has become incumbent upon us to increase the number of pages in our issue. Many of our readers have also PAGE'1 PAGE14 PAGE11 submitted pictures for publi- cation. Unfortunately, most of CONTENTS: 1984 the pictures that we receive are in color. Although we hope to SWEDEN: OVERSEAS UPDATE 4 eventually print in color, our SANTA BARBARA CLASSIC 4 present finances dictate that we LETTERS 6 print in black and white at least FRANCE: INTERNATIONAL TOURNAMENT 6 for the time being. l984 U.s. OPEN: LA MIRADA 7 In addition, in upcoming FOOTBAG: SACK SECTION 10 issues we will be including a SENIOR WORLDS 10 special footbag department. As a INTERVIEW: DAN RODDICK l2 result of having experienced PDGA 13 first hand the Hacky Sack and ROCKY MOUNTAIN NATIONALS: BOULDER 10 Frisbee Festival held here in San ROCKY MOUNTAIN NATIONALS: FT. COLLINS 12 Diego On July 7th, the unique INSTRUCTIONAL CORNER: BODY ROLLS 14 bond between footbag and disc has FPA WORLDS: MINNEAPOLIS 17 become increasingly apparent.
    [Show full text]
  • The Juggler of Notre Dame and the Medievalizing of Modernity. Volume 6: War and Peace, Sex and Violence
    The Juggler of Notre Dame and the Medievalizing of Modernity. Volume 6: War and Peace, Sex and Violence The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Ziolkowski, Jan M. The Juggler of Notre Dame and the Medievalizing of Modernity. Volume 6: War and Peace, Sex and Violence. Cambridge, UK: Open Book Publishers, 2018. Published Version https://www.openbookpublishers.com/product/822 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:40880864 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA The Juggler of Notre Dame and the Medievalizing of Modernity VOLUME 6: WAR AND PEACE, SEX AND VIOLENCE JAN M. ZIOLKOWSKI THE JUGGLER OF NOTRE DAME VOLUME 6 The Juggler of Notre Dame and the Medievalizing of Modernity Vol. 6: War and Peace, Sex and Violence Jan M. Ziolkowski https://www.openbookpublishers.com © 2018 Jan M. Ziolkowski This work is licensed under a Creative Commons Attribution 4.0 International license (CC BY 4.0). This license allows you to share, copy, distribute and transmit the work; to adapt the work and to make commercial use of the work providing attribution is made to the author (but not in any way that suggests that he endorses you or your use of the work). Attribution should include the following information: Jan M. Ziolkowski, The Juggler of Notre Dame and the Medievalizing of Modernity.
    [Show full text]
  • Comprehensive Security Analyses of a Toys-To-Life Game and Possible Countermeasures Master Thesis - July 2016
    Comprehensive security analyses of a toys-to-life game and possible countermeasures Master thesis - July 2016 Author Kevin Valk Radboud University [email protected] Supervisor Supervisor Second reader Robert Leyland Lejla Batina Eric Poll Radboud University Radboud University [email protected] [email protected] Abstract This thesis aims at modeling important attacks on a toys-to-life game using attack-defense trees. Using these trees, different practical attacks are executed to verify the current coun- termeasures and find possible new exploits. One critical exploit led to a binary dump of the firmware, which made it possible to reverse the key derivation algorithm. This led to breaking the security layer that protected the toys. With the key derivation algorithm known, toys could be forged for under a dollar and made it possible to search for unreleased toys and variants. Given the possible attacks, numerous countermeasures are presented to protect games against these attacks and improve general security. The foremost countermeasure is the addi- tion of digital signatures to the toys. This countermeasure makes it infeasible to forge toys. However, this does not stop 1-on-1 clones, but concepts are explored to protect against 1-on-1 clones in the future using Physical Unclonable Function (PUF). 1 Contents 1 Introduction 4 2 Background 5 2.1 Attack Trees.......................................5 2.1.1 Basic attack-defense trees............................5 2.1.2 Quantitative analysis...............................6 2.2 Public-key cryptography.................................6 2.3 Near Field Communication...............................7 2.3.1 MIFARE Classic.................................7 2.3.2 MIFARE Classic knockoff tags.........................8 3 Threat model 10 4 Attacks 14 4.1 Proxmark III......................................
    [Show full text]
  • Fire Performance Art Permit
    Policy Grants Pass Department of Public Safety 4XX Fire Policy Manual Fire Performance Art Permit 4XX.1 PURPOSE AND SCOPE The purpose of this policy is to provide guidelines to advise fire performance venues and artists of safety considerations and practices consistent with fire and life safety codes and public assembly safety concerns. 4XX.2 POLICY This policy applies to all acts of fire performance art occurring within all areas in which Grants Pass Department of Public Safety has authority. Fire art refers to performances or demonstrations such as fire breathing, fire juggling, fire dancing, etc. Not included: pyrotechnics and flame effects (these are addressed in a different policy and require a separate permit). The business owner, event coordinator and the fire performer are responsible for all aspects of fire and life safety. Failure to possess a current permit and follow the minimum requirements set forth in this document may result in revocation of permit, future permits and/or issuing of citation(s). Fire performance artists shall: 1. Be at least 18 years of age. a. EXCEPTION: Performers age 16 to 18 may be allowed at the discretion of the Fire Marshal’s Office with written consent from a parent or legal guardian. They must be under the direct supervision of an adult fire performance troupe leader or instructor. 2. Have valid, state issued identification and Fire Performance Permit readily accessible at each performance. 3. Audience: It should be recognized that audiences, especially youthful ones, may not fully understand the dangers associated with fire performance art. Every effort should be made to emphasize the safety precautions and dangers of such activity.
    [Show full text]
  • Idioms-And-Expressions.Pdf
    Idioms and Expressions by David Holmes A method for learning and remembering idioms and expressions I wrote this model as a teaching device during the time I was working in Bangkok, Thai- land, as a legal editor and language consultant, with one of the Big Four Legal and Tax companies, KPMG (during my afternoon job) after teaching at the university. When I had no legal documents to edit and no individual advising to do (which was quite frequently) I would sit at my desk, (like some old character out of a Charles Dickens’ novel) and prepare language materials to be used for helping professionals who had learned English as a second language—for even up to fifteen years in school—but who were still unable to follow a movie in English, understand the World News on TV, or converse in a colloquial style, because they’d never had a chance to hear and learn com- mon, everyday expressions such as, “It’s a done deal!” or “Drop whatever you’re doing.” Because misunderstandings of such idioms and expressions frequently caused miscom- munication between our management teams and foreign clients, I was asked to try to as- sist. I am happy to be able to share the materials that follow, such as they are, in the hope that they may be of some use and benefit to others. The simple teaching device I used was three-fold: 1. Make a note of an idiom/expression 2. Define and explain it in understandable words (including synonyms.) 3. Give at least three sample sentences to illustrate how the expression is used in context.
    [Show full text]
  • The University of Chicago Sentient Atmospheres A
    THE UNIVERSITY OF CHICAGO SENTIENT ATMOSPHERES A DISSERTATION SUBMITTED TO THE FACULTY OF THE DIVISION OF THE HUMANITIES IN CANDIDACY FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ENGLISH LANGUAGE AND LITERATURE BY JEFFREY HAMILTON BOGGS CHICAGO, ILLINOIS JUNE 2016 Copyright © 2016 by Jeffrey Hamilton Boggs All rights reserved Table of Contents ACKNOWLEDGEMENTS ........................................................................................................... iv INTRODUCTION .......................................................................................................................... 1 I. ATMOSPHERE IN LATE LATE JAMES ............................................................................... 21 II. “WE HAD THE AIR”: THE ATMOSPHERIC FORM OF THE VIETNAM WAR .............. 48 III. THIS IS AIR: THE ATMOSPHERIC POLITICS OF DAVID FOSTER WALLACE ......... 87 IV. NARRATING THE ANTHROPOCENE: THE ATMOSPHERIC COMEDY ................... 120 CODA: PLANETARY AIR ....................................................................................................... 150 BIBLIOGRAPHY ....................................................................................................................... 160 iii ACKNOWLEDGEMENTS I am grateful to the members of my dissertation committee for their unwavering support throughout the course of my academic progress. Bill Brown embodies the very best of the intellectual culture of the University of Chicago. He combines a big mind with a highly refined sensibility, exquisite taste
    [Show full text]
  • Understanding Siteswap Juggling Patterns a Guide for the Perplexed by Greg Phillips, [email protected]
    Understanding Siteswap Juggling Patterns A guide for the perplexed by Greg Phillips, [email protected] Core rules (for all patterns) Synchronous siteswap (simultaneous throws) C1 We imagine a metronome ticking at some constant rate. Some juggling patterns involve both hands throwing at the Each tick is called a “beat.” same time. We describe these using synchronous siteswap. C2 We indicate each thrown object by a number that tells us how many beats later that object must be back in a hand S1 The right and left hands throw at the same time (which and ready to re-throw. counts as two throws) on every second beat. We group C3 We indicate a sequence of throws by a string of numbers the simultaneous throws in parentheses and separate the (plus punctuation and the letter x). We imagine these hands with commas. strings repeat indefinitely, making 531 equivalent to S2 We indicate throws that cross from hand to hand with an …531531531… So are 315 and 153 — can you see x (for ‘xing’). why? C4 The sum of all throw numbers in a siteswap string divided Rules C2 and S1 taken together demand that there be only by the number of throws in the string gives the number of even numbers in valid synchronous siteswaps. Can you see objects in the pattern. This must always be a whole why? The x notation of rule S2 is required to distinguish number. 531 is a three-ball pattern, since (5+3+1)/3 patterns like (4,4) (synchronous fountain) from (4x,4x) equals three; however, 532 cannot be juggled since (synchronous crossing).
    [Show full text]
  • WORKSHOP SCHEDULE IJA Festival, Sparks, Nevada, July 26 - August 1, 2010
    WORKSHOP SCHEDULE IJA Festival, Sparks, Nevada, July 26 - August 1, 2010. For updates, see http://www.juggle.org/festival Tuesday, July 27 8:00am Joggling Competition 9:00am IJA College Credit Meeting -- Don Lewis 10:00am 3 Club Tricks -- Don Lewis (BEG) 10:00am Siteswap 101 -- Chase Martin (and Jordan Campbell) 10:00am Stretching and Increasing Your Flexibility -- Corey White 11:00am Blind Thows & Catches -- Thom Wall 11:00am Five Balls the Easy Way -- Dave Finnigan 11:00am Jammed Knot Knotting Jam -- John Spinoza 12:00pm 3/4 Ball Freezes -- Matt Hall 12:00pm Basic Hoop Juggling Technique -- Carter Brown 12:00pm Poi -- Sam Malcolm (BEG) 1:00pm Special Workshop -- Kris Kremo 1:00pm 180's/360's/720's -- Josh Horton & Doug Sayers 1:00pm Club Passing Routine -- Cindy Hamilton 1:00pm Tennis Ball/Can Breakout -- Dan Holzman 2:00pm Intro to Ball Spinning -- Bri Crabtree 2:00pm Multiplex Madness for Passing -- Poetic Motion Machine 3:00pm Fun/Simple Club Passing Patterns for 3/4/5 -- Louis Kruk 3:00pm 2 Diabolo Fundamentals and Combos -- Ted Joblin 3:00pm Kendama -- Sean Haddow (BEG/INT) 4:00pm Beginning Contact Juggling -- Kyle Johnson 4:00pm Diabolo Fundamentals -- Chris Garcia (BEG-ADV) Wednesday, July 28 9:00am IJA College Credit Meeting -- Don Lewis 9:00am YEP 1: Basic Techniques of Teaching Juggling -- Kim Laird 10:00am 3 Ball Esoterica -- Jackie Erickson (BEG/INT) 10:00am 5 Ball Tricks -- Doug Sayers & Josh Horton (INT/ADV) 10:00am YEP 2: How To Develop a Youth Program -- Kim Laird 11:00am Claymotion -- Jackie Erickson 11:00am Scaffolding:
    [Show full text]
  • HENRYS’ Own Production Only
    Professional Juggling Equipment GB 2016 Juggling Foreword Dear readers, Books Our last catalogue was showing articles from HENRYS’ own production only. We are now presenting our latest catalogue showing articles by other manufacturers. We are glad to be in a position to offer a great variety of products for juggling, acrobatics, unicycling and leisure. We are focussing on articles which meet the current requirements of our customers, and which are practical supplements of our own product range. Henrys GmbH Production and Trading of We offer products by Play (Italy), Beard (England), Bravo Juggling (Hungary), Spotlight (Holland), Filzis Jonglerie (Austria), Juggling Props and Toys La Ribouldingue (France), Goudrix (Canada), Mystec (Germany), Flairco (USA), Anderson & Berner (Denmark), Active People (Switzerland), Kendama Europe (Germany), Qualatex (USA), Pappnase (Germany), Tunturi (Holland), Superflight (USA), In den Kuhwiesen 10 Discraft (USA), WhamO (USA), New Games (Germany), Discrockers (Germany), TicToys (Germany), BumerangFan (France), D-76149 Karlsruhe QU-AX (Germany), Slackstar (Germany), and Kryolan (Germany). Product pictures and table arrangements help to keep the track and also to decide one way or the other. Most of the technical Fon ++49 (0) 721-78367-61|62|63 specifications are based on manufacture's data, differences caused by conversion of production possible! Fax ++49 (0) 721-7836777 E-mail [email protected] Enjoy reading and have fun browsing through the pages! Internet www.henrys-online.de Your HENRYS-Team Opening Hours 9.00 - 16.00 Mo-Tu 9.00 - 14.00 Fr Make-Up Activity Unicycles ᕍᕗ JugglingFlow Balls Juggling Beanbags Kids ᕃ ᕃ Beanbags made of synthetic leather with millet ice white silver red pink yellow green purple blue black orange Weight 00 01 02 03 04 05 06 07 08 12 13 g Code Rec.
    [Show full text]