Curriculum Vitae Cindy Hoffman, D.O., M.B.A., F.A.O.C.D
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A Deep Learning System for Differential Diagnosis of Skin Diseases
A deep learning system for differential diagnosis of skin diseases 1 1 1 1 1 1,2 † Yuan Liu , Ayush Jain , Clara Eng , David H. Way , Kang Lee , Peggy Bui , Kimberly Kanada , ‡ 1 1 1 Guilherme de Oliveira Marinho , Jessica Gallegos , Sara Gabriele , Vishakha Gupta , Nalini 1,3,§ 1 4 1 1 Singh , Vivek Natarajan , Rainer Hofmann-Wellenhof , Greg S. Corrado , Lily H. Peng , Dale 1 1 † 1, 1, 1, R. Webster , Dennis Ai , Susan Huang , Yun Liu * , R. Carter Dunn * *, David Coz * * Affiliations: 1 G oogle Health, Palo Alto, CA, USA 2 U niversity of California, San Francisco, CA, USA 3 M assachusetts Institute of Technology, Cambridge, MA, USA 4 M edical University of Graz, Graz, Austria † W ork done at Google Health via Advanced Clinical. ‡ W ork done at Google Health via Adecco Staffing. § W ork done at Google Health. *Corresponding author: [email protected] **These authors contributed equally to this work. Abstract Skin and subcutaneous conditions affect an estimated 1.9 billion people at any given time and remain the fourth leading cause of non-fatal disease burden worldwide. Access to dermatology care is limited due to a shortage of dermatologists, causing long wait times and leading patients to seek dermatologic care from general practitioners. However, the diagnostic accuracy of general practitioners has been reported to be only 0.24-0.70 (compared to 0.77-0.96 for dermatologists), resulting in over- and under-referrals, delays in care, and errors in diagnosis and treatment. In this paper, we developed a deep learning system (DLS) to provide a differential diagnosis of skin conditions for clinical cases (skin photographs and associated medical histories). -
2014 Slide Library Case Summary Questions & Answers With
2014 Slide Library Case Summary Questions & Answers with Discussions 51st Annual Meeting November 6-9, 2014 Chicago Hilton & Towers Chicago, Illinois The American Society of Dermatopathology ARTHUR K. BALIN, MD, PhD, FASDP FCAP, FASCP, FACP, FAAD, FACMMSCO, FASDS, FAACS, FASLMS, FRSM, AGSF, FGSA, FACN, FAAA, FNACB, FFRBM, FMMS, FPCP ASDP REFERENCE SLIDE LIBRARY November 2014 Dear Fellows of the American Society of Dermatopathology, The American Society of Dermatopathology would like to invite you to submit slides to the Reference Slide Library. At this time there are over 9300 slides in the library. The collection grew 2% over the past year. This collection continues to grow from member’s generous contributions over the years. The slides are appreciated and are here for you to view at the Sally Balin Medical Center. Below are the directions for submission. Submission requirements for the American Society of Dermatopathology Reference Slide Library: 1. One H & E slide for each case (if available) 2. Site of biopsy 3. Pathologic diagnosis Not required, but additional information to include: 1. Microscopic description of the slide illustrating the salient diagnostic points 2. Clinical history and pertinent laboratory data, if known 3. Specific stain, if helpful 4. Clinical photograph 5. Additional note, reference or comment of teaching value Teaching sets or collections of conditions are especially useful. In addition, infrequently seen conditions are continually desired. Even a single case is helpful. Usually, the written submission requirement can be fulfilled by enclosing a copy of the pathology report prepared for diagnosis of the submitted case. As a guideline, please contribute conditions seen with a frequency of less than 1 in 100 specimens. -
General Clues Questions
Cambridge University Press 978-1-316-62287-2 — Self-Assessment in Dermatopathology Meera Mahalingam Excerpt More Information General Clues A Questions 1. This is likely a consequence of: C. Microvenular hemangioma D. Monsel’s tattoo E. Stasis dermatitis 3. This is typically associated with: A. Embedding B. Autolysis C. Fixation D. Cautery E. Grossing 2. The most likely diagnosis is: A. Contact dermatitis B. Lupus erythematosus C. Seborrheic dermatitis D. Hartnup disease E. Stasis dermatitis 4. This is typically associated with: A. Dermatofibroma B. Cautery artefact 1 © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-316-62287-2 — Self-Assessment in Dermatopathology Meera Mahalingam Excerpt More Information Self-Assessment in Dermatopathology A. Pityriasis rosea 8. Intraluminal giant cells may be seen in: B. Pityriasis rubra pilaris A. Juvenile xanthogranuloma C. Pityriasis lichenoides chronica B. Rosai-Dorfman disease D. Pityriasis lichenoides et varioliformis acuta C. Wells’s syndrome E. Transient acantholytic dermatosis D. Erythema nodosum leprosum E. Lichen nitidus 5. Which of the following is NOT a clue to a deficiency state: A. Vertically oriented collagen 9. Which of the following is an INCORRECT association: B. Confluent parakeratosis A. Tricholemmoma and Brooke-Spiegler syndrome C. Superficial epidermal pallor B. Sebaceous adenoma and Muir-Torre syndrome D. Psoriasiform epidermal hyperplasia C. Cutaneous myxoma and Carney’s complex E. Hemorrhage D. Fibrofolliculoma and Birt-Hogg-Dubé syndrome E. Leiomyomas and Reed’s syndrome 6. Which of the following is NOT a paraneoplastic dermatosis: 10. Which of the following is NOT a proto-oncogene: A. Acanthosis nigricans A. -
Stress and Inflammatory Skin Disorders: a Review of Non-Pharmacologic Treatments
JAOCDJournal Of The American Osteopathic College Of Dermatology Volume 26 pg. 12 Stress and Inflammatory Skin Disorders: A Review of Non-Pharmacologic Treatments Also in this issue: last modified on September 24, 2013 1:07 PM JOURNAL OF THE AMERICAN OSTEOPATHIC COLLEGE OF DERMATOLOGY Page 1 JOURNAL OF THE AMERICAN OSTEOPATHIC COLLEGE OF DERMATOLOGY 2012-2013 OFFICERS PRESIDENT David L. Grice, DO, FAOCD PRESIDENT-ELECT Suzanne Sirota-Rozenberg, DO, FAOCD FIRST VICE-PRESIDENT Rick J. Lin, DO, FAOCD SECOND VICE-PRESIDENT Alpesh Desai, DO, FAOCD THIRD VICE-PRESIDENT Editor-in-Chief Karthik Krishnamurthy, DO, FAOCD Karthik Krishnamurthy, DO IMMEDIATE PAST-PRESIDENT Bradley Glick, DO, FAOCD TRUSTEES Danica Alexander, DO, FAOCD Reagan Anderson, DO, FAOCD Sponsors: Mark A. Kuriata, DO, FAOCD Daniel Ladd, DO, FAOCD Bayer John P. Minni, DO, FAOCD Bryan Sands, DO, FAOCD AuroraDx SECRETARY-TREASURER Medicis Jere J. Mammino, DO, FAOCD Ranbaxy EXECUTIVE DIRECTOR Marsha A. Wise, B.S. JAOCD Founding Sponsor AOCD • 2902 N. Baltimore St. • Kirksville, MO 63501 800-449-2623 • FAX: 660-627-2623 www.aocd.org COPYRIGHT AND PERMISSION: Written permission must be obtained from the Journal of the American Osteopathic College of Dermatology for copying or reprinting text of more than half a page, tables or figures. Permissions are normally granted contingent upon similar permission from the author(s), inclusion of acknowledgement of the original source, and a payment of $15 per page, table or figure of reproduced material. Permission fees are waived for authors wishing to reproduce their own articles. Request for permission should be directed to JAOCD c/o AOCD, PO Box 7525, Kirksville, MO 63501. -
Jennifer a Cafardi the Manual of Dermatology 2012
The Manual of Dermatology Jennifer A. Cafardi The Manual of Dermatology Jennifer A. Cafardi, MD, FAAD Assistant Professor of Dermatology University of Alabama at Birmingham Birmingham, Alabama, USA [email protected] ISBN 978-1-4614-0937-3 e-ISBN 978-1-4614-0938-0 DOI 10.1007/978-1-4614-0938-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011940426 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identifi ed as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Notice Dermatology is an evolving fi eld of medicine. -
Use of Serine Protease Inhibitors in the Treatment
(19) TZZ _T (11) EP 2 244 728 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61P 17/00 (2006.01) A61K 38/55 (2006.01) 31.08.2016 Bulletin 2016/35 A61Q 19/00 (2006.01) A61K 38/48 (2006.01) G01N 33/50 (2006.01) (21) Application number: 09703640.4 (86) International application number: (22) Date of filing: 21.01.2009 PCT/IB2009/000089 (87) International publication number: WO 2009/093119 (30.07.2009 Gazette 2009/31) (54) USE OF SERINE PROTEASE INHIBITORS IN THE TREATMENT OF SKIN DISEASES VERWENDUNG VON SERINPROTEASEHEMMERN BEI DER BEHANDLUNG VON HAUTERKRANKUNGEN UTILISATION D’INHIBITEURSDE SÉRINE PROTÉASES POUR TRAITER DES MALADIES DE PEAU (84) Designated Contracting States: (56) References cited: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR EP-A- 0 567 816 WO-A-00/07620 HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL WO-A-2004/045634 WO-A-2005/117955 PT RO SE SI SK TR WO-A-2006/037606 WO-A-2006/090282 WO-A-2007/072012 WO-A-2009/024528 (30) Priority: 21.01.2008 US 22386 US-A1- 2003 054 445 22.01.2008 US 6576 • ONG C ET AL: "LEKTI demonstrable by (43) Date of publication of application: immunohistochemistry of the skin: a potential 03.11.2010 Bulletin 2010/44 diagnostic skin test for Netherton syndrome" BRITISHJOURNAL OF DERMATOLOGY,vol. 151, (73) Proprietors: no.6, December 2004 (2004-12), pages 1253-1257, • DERMADIS XP002548095 ISSN: 0007-0963 74160 Archamps (FR) • SCHECHTER N M ET AL: "Inhibition of human • Institut National de la Santé et de la Recherche kallikrein-5 (SCTE) and-7 (SCCE) by Médicale lympho-epithelial Kazal-type inhibitor (LEKTI) 75013 Paris (FR) supports a role for proteolysis in Netherton disease and desquamation" JOURNAL OF (72) Inventors: INVESTIGATIVE DERMATOLOGY, vol. -
Pityriasis Rosea • Pityriasis Rotunda • Granular Parakeratosis SMALL PLAQUE PARAPSORIASIS
Papulo-Squamous Disorders Papulo-Squamous Disorders • Small Plaque Parapsoriasis • Large Plaque Parapsoriasis • Pityriasis Lichenoides Et Varioliformis Acuta & Pityriasis Lichenoides Chronica • Pityriasis Rubra Pilaris • Pityriasis Rosea • Pityriasis Rotunda • Granular Parakeratosis SMALL PLAQUE PARAPSORIASIS • Chronic, asymptomatic, erythematous scaly patches. Lesions are generally <5 cm in diameter or digitate. • Histologically, mild, nonspecific spongiotic dermatitis with parakeratosis is seen • CD4+ T cells predominance in the lymphocytic infiltrate • A dominant T-cell clonality is demonstrable in some cases. • This group is significant for the tendency of its disorders to coexist or overlap with one another and for its association with lymphomas. • Small plaque parapsoriasis typically presents as round–oval patches that are generally <5 cm in diameter. • They are variably erythematous (but often less intense than psoriasis) and covered with a fine scale. • Variants: • Xanthoerythrodermia perstans: yellow hue • Digitate dermatosis: – Elongated – Finger-like patches – Symmetrically distributed – On the flanks. LARGE PLAQUE PARAPSORIASIS • Chronic, asymptomatic, erythematous scaly patches • Lesions are generally >5 cm in diameter • Histologically, a nonspecific spongiotic dermatitis or an interface lymphocytic infiltrate with a variable degree of lichenoid features is seen • CD4+ T cells predominance in the lymphocytic infiltrate • A dominant T-cell clonality is demonstrable in many cases • It is thought that large plaque parapsoriasis represents the earliest stage of mycosis fungoides • Variably erythematous, round or irregularly shaped, scaly patches that are >5 cm in diameter. • They may or may not exhibit the clinical triad of atrophy, telangiectasia, and hyper/hypopigmentation (poikiloderma vasculare atrophicans). • Variant: “Retiform parapsoriasis” • Syn. Parapsoriasis variegata, parakeratosis variegata or parapsoriasis lichenoides. • Rare variant. • Widespread, ill-defined patches in a net-like or zebra-stripe pattern. -
Absolute Dermatology Review
Absolute Dermatology Review Hugh Morris Gloster, Jr. • Lauren E. Gebauer Rachel L. Mistur Absolute Dermatology Review Mastering Clinical Conditions on the Dermatology Recertifi cation Exam Hugh Morris Gloster, Jr. Rachel L. Mistur Professor of Dermatology College of Medicine University of Cincinnati School of Medicine University of Cincinnati Cincinnati, Ohio Cincinnati , Ohio USA USA Lauren E. Gebauer Department of Dermatology University of Cincinnati Dermatology Surgical Fellow Cincinnati , Ohio USA ISBN 978-3-319-03217-7 ISBN 978-3-319-03218-4 (eBook) DOI 10.1007/978-3-319-03218-4 Library of Congress Control Number: 2015941104 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. -
A 1A4 Antibodies
1 Index Note: References are to pages within chapters, thus 51.10 is page 10 of Chapter 51. Tables and/or Figures removed from the main text are in italic. Main entries are in bold. Alphabetical order is word-by-word, in which hyphens are given the fi ling role of a space. A acantholytic dermatoses see Grover’s acetylacetone test 26.50, 26.99 in psoriasis 20.37, 74.35 1A4 antibodies (alpha-smooth muscle disease (transient and persistent acetylated lanolin alcohol 27.13 in psoriatic nail involvement 65.26 actin antibodies) 10.22 acantholytic dermatoses) acetylcholine (ACh) 38.1, 44.3, 63.3, 80.7 in squamous cell carcinoma 52.28 AA see alopecia areata (AA) acantholytic dyskeratotic epidermal naevi in atopic dermatitis 24.18 teratogenicity 72.28 Aagenaes syndrome 48.10 19.83 peripheral nerves 4.10 Ackerman syndrome 15.29 abacavir 75.67 acanthoma pruritus and 21.3, 21.4 acne hypersensitivity 35.7, 35.21, 72.30 clear cell 52.41 sweat gland control 3.12 adolescent see acne vulgaris abatacept 74.9 Degos’ 52.41 acetylcholinesterase 3.12 childhood 42.75–6 ABC method (avidin–biotin–peroxidase pilar sheath 53.3 N-acetylcysteine 26.46, 47.11 cosmetic 42.73 complex method) 10.17 spectacle-frame (acanthoma fi ssuratum) in microscopic polyangiitis 50.36 drug-induced 9.5, 42.31, 42.71–3, 75.34 ABCA12 gene 11.13 28.29–30, 68.9 ACh see acetylcholine (ACh) ear 68.14 ABCB1 (MDR-1) gene 72.29 acanthoma fi ssuratum 28.29–30, 68.9 Achenbach’s syndrome 28.27, 45.4, 45.5, endocrine 42.73 ABCD dermatoscopy score 5.20 acanthome a ‘cellules claires’ 52.41 49.16 external -
November 2006 Resident Dermatology a Publication of the American Osteopathic College of Dermatology Contents
A PUBLICATION OF THE AMERICAN OSTEOPATHIC COLLEGE OF DERMATOLOGY Accepting Manuscripts from Dermatology Residents in AOA and ACGME Approved Residency Programs FOUNDING SPONSORS:ALLERGAN SKIN CARE • CONNETICS CORPORATION • GLOBAL PATHOLOGY LABORATORY • MEDICIS • STIEFEL LABORATORIES Journal of RESIDENT DERMATOLOGY A PUBLICATION OF THE AMERICAN OSTEOPATHIC COLLEGE OF DERMATOLOGY 2006-2007 Officers President: Bill V. Way, D.O. Journal President Elect: Jay S. Gottlieb, D.O. First Vice-President: D.O.nald K. Tillman, D.O. Second Vice-President: Marc I. Epstein, D.O. Third Vice-President: Leslie Kramer, D.O. of Resident Secretary-Treasure: Jere J. Mammino, D.O. Immediate Past-President: Richard A. Miller, D.O. Trustees: Bradley P. Glick, D.O. Jeffrey N. Martin, D.O. Dermatology Karen E. Neubauer, D.O. James B. Towry, D.O. A PUBLICATION OF THE AMERICAN OSTEOPATHIC COLLEGE OF DERMATOLOGY Executive Director: Rebecca Mansfield, M.A. Editors Jay S. Gottlieb, D.O., F.O.C.O.O. Stanley E. Skopit, D.O., F.A.O.C.D. Founding Sponsors: James Q. Del Rosso, D.O., F.A.O.C.D. Allergan Skin Care Connetics Corporation Global Pathology Laboratory Medicis Editorial Review Board Stiefel Laboratories Ronald Miller, D.O. Eugene Conte, D.O. Evangelos Poulos, M.D. Stephen Purcell, D.O. AOCD • 1501 E. Illinois • Kirksville, MO 63501 Darrel Rigel, M.D. 800-449-2623 • FAX: 660-627-2623 Robert Schwarze, D.O. www.aocd.org Andrew Hanly, M.D. Michael Scott, D.O. COPYRIGHT AND PERMISSION: written permission must be obtained from the Journal of the American Osteopathic College of Cindy Hoffman, D.O.