Supplementary Information for ‘Covid-19 vaccine-induced antibodies are attenuated and decay rapidly in infliximab treated patients’
Table of Contents Supplementary Table 1: Contributors to the CLARITY IBD study ...... 2 Supplementary Table 2: Baseline characteristic of participants who had anti-SARS-CoV-2 spike antibodies measured 2 to 10 weeks following 2 doses of vaccine against SARS-CoV-2 ...... 23
Supplementary Table 1: Contributors to the CLARITY IBD study
Affiliation First name Surname
Barts Health NHS Trust Klaartje Kok
Farjhana Bokth
Bessie Cipriano
Caroline Francia
Nosheen Khalid
Hafiza Khatun
Ashley Kingston
Irish Lee
Anouk Lehmann
Kinnari Naik
Elise Pabriaga
Nicolene Plaatjies
Kevin Samuels
Barts Health NHS Trust (paediatric) Bessie Cipriano
Kevin Samuels
Nicolene Plaatjies
Hafiza Khatun
Farjana Bokth
Elise Pabriaga
Caroline Francia
Basingstoke and North Hampshire Rebecca Saich Hospital Hayley Cousins
Wendy Fraser
Rachel Thomas
Matthew Brown
2
Affiliation First name Surname
Benjamin White
Basingstoke and North Hampshire Hospital Nikolaos. Kirkineziadis
Bernadette Tilley
Birmingham Women's and Children's NHS Rafeeq Muhammed Foundation Trust Rehana Bi
Catherine Cotter
Jayne Grove
Kate Hong
Ruth Howman
Monica Mitchell
Sophie Clayton
Sugrah Sultan
Melanie Rooney
Charlotte Cottrill
Bolton NHS Foundation Trust Salil Singh
Chris Dawe
Robert Hull
Natalie Silva
Borders General Hospital Jonathan Manning
Lauren Finlayson
Allison Roebuck
Joy Dawson
Calderdale and Huddersfield NHS Sunil Sonwalkar Foundation Trust Naomi Chambers
Matthew Robinson
Andrew Haigh
3
Affiliation First name Surname
Lear Matapure
Cambridge University Hospitals NHS Tim Raine Foundation Trust Varun George
Christina Kapizioni
Konstantina Strongili
Tina Thompson
Mohamed Ahmed
Christos Kontos
Cambridge Institute of Therapeutic Christophe Bourges Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Isabella Barbutti Cambridge Megan E Gozzard
Chelsea and Westminster Hospital NHS Philip Hendy Foundation Trust Rhian Bull
Patricia Costa
Lisa Davey
Hayley Hannington
Kribashnie Nundlall
Catarina Martins
Laura Avanzi
Jaime Carungcong
Sabrina Barr
Richard Appleby
Emma Johnson
Chesterfield Royal Hospital Kath Phillis
Rachel Gascoyne
Amanda Crowder
Amanda Whileman
4
Affiliation First name Surname
Countess Of Chester Hospital NHS Ian London Foundation Trust Jenny Grounds
Emmeline Martin
Susie Pajak
Jude Price
Kathryn Cawley
Darlington Memorial Hospital Anjan Dhar
Ellen Brown
Amanda Cowton
Kimberley Stamp
Dartford and Gravesham NHS Trust Ben Warner
Carmel Stuart
Louise Lacey
The Dudley Group NHS Foundation Trust Shanika de Silva
Clare Allcock
Philip Harvey
Lesley Jones
Elise Cooke
East and North Hertfordshire NHS Trust Johanne Brooks
Pearl Baker
Hannah Beadle
Carina Cruz
Debbie Potter
East Lancashire Hospitals NHS Trust Joe Collum
Farzana Masters
Glangwili Hospital Aashish Kumar
Samantha Coetzee
5
Affiliation First name Surname
Mihaela Peiu
Becky Icke
Meena Raj
Great Ormond Street Hospital Edward Gaynor
Sibongile Chadokufa
Bonita Huggett
Hamza Meghari
Sara El-Khouly
Fevronia Kiparissi
Waffa Girshab
Great Western Hospitals NHS Foundation Andrew Claridge Trust Emily Fowler
Laura McCafferty
Guy's and St Thomas' NHS Foundation Peter Irving Trust Karolina Christodoulides
Angela Clifford
Patrick Dawson
Sailish Honap
Samuel Lim
Raphael Luber
Karina Mahiouz
Susanna Meade
Parizade Raymode
Rebecca Reynolds
Anna Stanton
Sherill Tripoli
Naomi Hare
6
Affiliation First name Surname
Senthuran Balachandran
Emma North
Jessica North
Bria Browne
Ella Jameson
The Hillingdon Hospitals NHS Foundation Yih Harn Siaw Trust Lane Manzano
Jonathan Segal
Ibrahim Al-Bakir
Imran Khakoo
Homerton University Hospital Foundation Nora Thoua Trust Katherine Davidson
Jagrul Miah
Lisa Canclini
Alex Hall
Hull University Teaching Hospitals NHS Shaji Sebastian Trust Melony Hayes
Sally Myers
Alison Talbot
Jack Turnbull
Emma Whitehead
Katie Stamp
Alison Pattinson
Verghese Mathew
Leanne Sherris
Hull University Teaching Hospitals NHS Trust Angela Harvey
7
Affiliation First name Surname
Imperial College Healthcare NHS Trust Lucy Hicks
Tara-Marie Byrne
Leilani Cabreros
Hannah Downing-Wood
Sophie Hunter
Mohammad Aamir Saifuddin
Hemanth Prabhudev
Sharmili Balarajah
Faculty of Medicine, Imperial College Hajir Ibraheim London Melissa Torkizadeh
Jonathan W Lo
Zhigang Liu
James Paget University Hospitals NHS Helen Sutherland Foundation Trust Elva Wilhelmsen
Katherine Mackintosh
Kettering General Hospital Ajay M Verma
Juliemol Sebastian
Mohammad Farhad Peerally
Parizade Raymode
Anne-marie Guerdette
King's College Hospital NHS Foundation Alexandra Kent Trust Lee Meng Choong
Benedetta Pantaloni
Pantelis Ravdas
King's College Hospital NHS Foundation Babu Vadamalayan Trust (paediatric)
King’s Mill Hospital Stephen Foley
8
Affiliation First name Surname
Becky Arnold
Cheryl Heeley
Wayne Lovegrove
Donna Sowton
Lynne Allsop
Heidi Gregory
Liverpool University Hospitals NHS Philip J Smith Foundation Trust Giovanna Bretland
Sarah King
Martina Lofthouse
Lindsey Rigby
Sreedhar Subramanian
David Tyrer
Kate Martin
Christopher Probert
London North West University Healthcare Nikolaos Kamperidis NHS Trust Temi Adedoyin
Manisha Baden
Jeannette Brown
Feba Chacko
Michela Cicchetti
Mohammad Saifuddin
Priya Yesupatham
Maidstone and Tunbridge Wells NHS Trust Rohit Gowda
Maureen Williams
Manchester University NHS Foundation Karen Kemp Trust Rima Akhand
9
Affiliation First name Surname
Glaxy Gray
Anu John
Maya John
Tasnim Mohammed
Diamond Sathe
Natasha Jones
Jennifer Soren
The Mid Yorkshire Hospitals NHS Trust Michael Sprakes
Julie Burton
Patricia Kane
Stephanie Lupton
Jacqueline Bartholomew
Milton Keynes University Hospital George MacFaul
Diane Scaletta
Loria Siamia
Felicity Williams
Chloe Green
Zeljka Ver
Newcastle Hospitals NHS Foundation Trust Chris Lamb
Mary Doona
Ashleigh Hogg
Lesley Jeffrey
Andrew King
R Alexander Speight
Jennifer Doyle
Ruth Owen
Ninewells Hospital & Medical School Craig Mowat
10
Affiliation First name Surname
Debbie Rice
Susan MacFarlane
Anne MacLeod
Samera Mohammed
Ninewells Hospital & Medical Shona Murray
Anne Elliott
Norfolk and Norwich University Hospitals Mary Anne Morris NHS Foundation Trust Louise Coke
Grace Hindle
Eirini Kolokouri
Catherine Wright
Claire Lee
Nicola Ward
Adele Dann
North Bristol NHS Trust Melanie Lockett
Charlotte Cranfield
Louise Jennings
Ankur Srivastava
Lana Ward
Nouf Jeynes
Poonam Ranga
North Tyneside General Hospital Praveen Rajasekhar
Lisa Gallagher
Linda Patterson
Jill Ward
Rae Basnett
Judy Murphy
11
Affiliation First name Surname
Lauren Parking
Emma Lawson
Stacey Short
Nottingham University Hospitals NHS Trust David Devadason
Gordon Moran
Neelam Khan
Lauren Tarr
Charmaine Olivia
The Pennine Acute Hospitals NHS Trust Jimmy Limdi
Kay Goulden
Asad Javed
Lauren McKenzie
Portsmouth Hospitals NHS Trust Pradeep Bhandari
Michelle Baker-Moffatt
Joanne Dash
Allison Le Poidevin
Hayley Downe
Lucille Bombeo
Helen Blackman
The Queen Elizabeth Hospital Kings Lynn Alan Wiles NHS Trust Hannah Bloxham
Jose Dias
Evelyn Nadar
Hollie. Curgenven
Queen Elizabeth University Hospital, Jonathan Macdonald Glasgow Shona Finan
Faye McMeeken
12
Affiliation First name Surname
Misbah Mahmood
Stephanie Shields
John Paul Seenan
Royal Berkshire NHS Foundation Trust Des DeSilva
Susanna Malkakorpi
Rachel Carson
University Hospitals Dorset NHS Simon Whiteoak Foundation Trust Kelli Edger-Earley
Luke Vamplew
Royal Cornwall Hospitals NHS Trust Sarah Ingram
Sharon Botfield
Fiona Hammonds
Clare James
Royal Devon and Exeter NHS Foundation Tariq Ahmad Trust Gemma Aspinall
Sarah Hawkins
Suzie Marriott
Clare Redstone
Halina Windak
Ana-Marie Adam
Hannah Mabb
Royal Free London NHS Foundation Trust Charles Murray
Cynthia Diaba
Fexy Joseph
Glykeria Pakou
Yvonne Gleeson
Royal Glamorgan Hospital James Berrill
13
Affiliation First name Surname
Natalie Stroud
Carla Pothecary
Lisa Roche
Keri Turner
Lisa Deering
Lynda Israel
Royal Gwent Hospital Evelyn Baker
Sean Cutler
Rina Mardania Evans
Maxine Nash
Georgina Mallison
Anna Roynon
Royal Hampshire County Hospital John Gordon
Emma Levell
Silvia Zagalo
Wendy Fraser
Ina Hoad
Nikolaos Kirkineziadis
Royal Hospital for Sick Children, Richard Russell Edinburgh Paul Henderson
Margaret Millar
Royal Manchester Children's Hospital Andrew Fagbemi
Felicia Jennings
Imelda Mayor
Jill Wilson
Royal Surrey County Hospital Christopher Alexakis
Natalia Michalak
14
Affiliation First name Surname
Royal United Hospitals Bath John Saunders
Helen Burton
Vanessa Cambridge
Tonia Clark
Charlotte Ekblad
Sarah Hierons
Joyce Katebe
Emma Saunsbury
Rachel Perry
The Royal Wolverhampton NHS Trust Matthew Brookes
Kathryn Davies
Marie Green
Ann Plumbe
Salford Royal NHS Foundation Trust Clare Ormerod
Helen Christensen
Anne Keen
Jonathan Ogor
Salisbury District Hospital Alpha Anthony
Emily Newitt
Fiona Trim
Ruth Casey
Katherine Seymour
Sandwell and West Birmingham NHS Trust Edward Fogden
Kalisha Russell
Sheffield Teaching Hospitals NHS Anne Phillips Foundation Trust Muaad Abdulla
Shrewsbury and Telford Hospital NHS Trust Jeff Butterworth
15
Affiliation First name Surname
Colene Adams
Elizabeth Buckingham
Danielle Childs
Alison Magness
Jo Stickley
Nichola Motherwell
Louise Tonks
Hannah Gibson
S Pajak
Singleton Hospital Caradog Thomas
Elaine Brinkworth
Lynda Connor
Amanda Cook
Tabitha Rees
Rachel Harford
Somerset NHS Foundation Trust Emma Wesley
Alison Moss
Jacob Lucas
Claire Lorimer
Maria Oleary
Maxine Dixon
South Tees Hospitals NHS Foundation Trust Arvind Ramadas
Julie Tregonning
Olaku Okeke
Wendy Jackson
Southend University Hospital NHS Ioannis Koumoutsos Foundation Trust Viji George
16
Affiliation First name Surname
Swapna Kunhunny
Sophie Laverick
Isla Anderson
Sophie Smith
St George's University Hospitals NHS Kamal Patel Foundation Trust Mariam Ali
Hilda Mhandu
Aleem Rana
Katherine Spears
Joana Teixeira
Richard Pollok
Mark Mencias
Abigail Seaward
Jessica Sousa
St Georges University Hospital NHS Trust Nooria Said
Mark Soomaroo
Valentina Raspa
Asha Tacouri
St George's University Hospitals NHS Nicholas Reps Foundation Trust (paediatric) Rebecca Martin
St James’s University Hospital Christian Selinger
Jenelyn Carbonell
Felicia Onovira
Doris Quartey
Alice L’Anson
Andrew Ashworth
Jessica Bailey
17
Affiliation First name Surname
Angie Dunn
Stockport NHS Foundation Trust Zahid Mahmood
Racheal Campbell
Liane Marsh
Surrey and Sussex Healthcare NHS Trust Monira Rahman
Sarah Davies
Ruth Habibi
Ellen Jessup-Dunton
Teishel Joefield
Reina Layug
Tameside and Glossop Integrated Care Vinod Patel NHS Foundation Trust Joanne Vere
Victoria Turner
Susan Kilroy
Torbay and South Devon NHS Foundation Gareth Walker Trust Stacey Atkins
Jasmine Growdon
Charlotte McNeill
University Hospitals Birmingham NHS Rachel Cooney Foundation Trust Lillie Bennett
Louise Bowlas
Sharafaath Shariff
University Hospitals Bristol NHS Foundation Aileen Fraser Trust Dwayne Punnette
Charlotte Bishop-Hurman
Elizabeth Undrell
Katherine Belfield
18
Affiliation First name Surname
University Hospitals of Derby and Burton Said Din NHS Foundation Trust Catherine Addleton
Marie Appleby
Johanna Brown
Kathleen Holding
University Hospitals of Leicester NHS Trust Patricia Hooper
John deCaestecker
Olivia Watchorn
University Hospitals Plymouth NHS Trust Chris Hayward
Susan Inniss
Lucy Pritchard
Karen Rudge
Amanda Carney
United Lincolnshire Hospitals NHS Trust Jervoise Andreyev
Caroline Hayhurst
Carol Lockwood
Lynn Osborne
Amanda Roper
Karen Warner
Julia Hindle
Caroline Watt
Kinga Szymiczek
University College London Hospitals NHS Shameer Mehta Foundation Trust James Bell
William Blad
Lisa Whitley
University Hospital Llandough Durai Dhamaraj
19
Affiliation First name Surname
Mark Baker
Elizabeth John Sivamurugan
Mim Evans
University Hospital Southampton NHS Fraser Cummings Foundation Trust Clare Harris
Amy Jones
Liga Krauze
Sohail Rahmany
Michelle Earl
Jenny Vowles
Audrey Torokwa
Mirela Petrova
Andrew Procter
Jo Stanley
Claudia Silvamoniz
Marion Bettey
University Hospital of Wales (paediatric) Amar Wahid
Zoe Morrison
Rhian Thomas-Turner
Louise Yendle
Jennifer Muller
Exeter NIHR Clinical Research Facility, Marcus Mitchell University of Exeter John Kirkwood
Anna Barnes
West Hertfordshire Hospitals NHS Trust Rakesh Chaudhary
Melanie Claridge
Chiara Ellis
20
Affiliation First name Surname
Cheryl Kemp
Ogwa Tobi
Jentus Milton
West Middlesex University Hospital Emma Johnston
Metod Oblak
Richard Appleby
West Suffolk NHS Foundation Trust Jo Godden
Western General Hospital Charlie Lees
Debbie Alexander
Kate Covil
Lauranne Derikx
Sryros Siakavellas
Helen Baxter
Scott Robertson
Linda Smith
Beena Poulose
Anne Colemam
Margareta Balint
Gareth Rhys-Jones
Withybush General Hospital Kerrie Johns
Rachel Hughes
Janet Phipps
Abigail Taylor
Withybush General Hospital Catherine MacPhee
Suzanne Brooks
Yeovil District Hospital NHS Foundation Katie Smith Trust Linda Howard
21
Affiliation First name Surname
Dianne Wood
York Teaching Hospital NHS Foundation Ajay Muddu Trust Laura Barman
Janine Mallinson
Tania Neale
Diana Ionita
Kerry Elliot
Alison Turnball
Ysbyty Gwynedd Iola Thomas
Kelly Andrews
Jonathon Sutton
Caroline Mulvaney Jones
Julia Roberts
Jeannie Bishop
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Supplementary Table 2: Baseline characteristics of participants who had anti- SARS-CoV-2 spike antibodies measured 2 to 10 weeks following 2 doses of vaccine against SARS-CoV-2 Variable Level Vedolizumab Infliximab Overall p Vaccine BNT162b2 40·8% (377/925) 41·9% (860/2052) 41·6% (1237/2977) 0·57 ChAdOx1 nCoV-19 59·2% (548/925) 58·1% (1192/2052) 58·4% (1740/2977) Age (years) 49·4 (36·2 - 62·4) 40·7 (30·5 - 53·7) 42·9 (32·0 - 56·3) <0·0001 Sex Female 48·4% (445/919) 47·2% (963/2041) 47·6% (1408/2960) 0·28 Male 51·4% (472/919) 52·8% (1077/2041) 52·3% (1549/2960) Intersex 0·0% (0/919) 0·0% (0/2041) 0·0% (0/2960) Prefer not to say 0·2% (2/919) 0·0% (1/2041) 0·1% (3/2960) Ethnicity White 90·1% (827/918) 92·8% (1894/2040) 92·0% (2721/2958) 0·010 Asian 6·8% (62/918) 4·3% (88/2040) 5·1% (150/2958) Mixed 2·3% (21/918) 1·4% (28/2040) 1·7% (49/2958) Black 0·5% (5/918) 0·7% (14/2040) 0·6% (19/2958) Other 0·3% (3/918) 0·8% (16/2040) 0·6% (19/2958) Diagnosis Crohn's disease 37·2% (344/925) 67·0% (1374/2052) 57·7% (1718/2977) <0·0001 UC/IBDU 62·8% (581/925) 33·0% (678/2052) 42·3% (1259/2977) Duration of IBD (years) 9·0 (5·0 - 18·0) 8·0 (3·0 - 16·0) 9·0 (4·0 - 17·0) 0·00015 Age at IBD diagnosis (years) 34·6 (23·6 - 48·1) 27·9 (20·5 - 40·0) 29·6 (21·1 - 42·7) <0·0001 Immunomodulators at vaccine 21·3% (197/924) 58·6% (1202/2051) 47·0% (1399/2975) <0·0001 5-ASA 34·3% (317/924) 21·2% (435/2051) 25·3% (752/2975) <0·0001 Steroids 6·4% (59/924) 2·9% (59/2051) 4·0% (118/2975) <0·0001 BMI 26·0 (23·1 - 29·8) 26·0 (22·8 - 30·2) 26·0 (22·9 - 30·1) 0·93 Heart disease 5·1% (47/918) 2·8% (56/2036) 3·5% (103/2954) 0·0016 Diabetes 8·1% (74/918) 3·8% (77/2036) 5·1% (151/2954) <0·0001 Lung disease 16·1% (148/918) 13·8% (281/2036) 14·5% (429/2954) 0·10 Kidney disease 2·0% (18/918) 0·9% (18/2036) 1·2% (36/2954) 0·018 Cancer 1·5% (14/918) 0·3% (6/2036) 0·7% (20/2954) 0·00038 Smoker Yes 7·2% (66/918) 10·7% (217/2036) 9·6% (283/2954) 0·00050 Not currently 38·2% (351/918) 30·5% (620/2036) 32·9% (971/2954) Never 54·6% (501/918) 58·9% (1199/2036) 57·5% (1700/2954) Exposure to documented cases 7·8% (72/918) 8·2% (166/2036) 8·1% (238/2954) 0·83 of COVID-19 Income deprivation score 0·089 (0·055 - 0·146) 0·091 (0·053 - 0·153) 0·090 (0·054 - 0·151) 0·83 Active disease (PRO2) 9·8% (86/880) 5·5% (107/1945) 6·8% (193/2825) <0·0001
Abbreviations: IBD = inflammatory bowel disease; 5-ASA = 5-aminosalicylic acid; BMI = Body Mass Index; PRO2 = IBD disease activity. Values presented are median (interquartile range) or percentage (numerator/denominator). P values represent the results of a Mann Whitney U, Kruskal Wallis or Fisher’s exact test.
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