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International Genome-Wide Meta-Analysis Identifies New Primary Biliary Cirrhosis Risk Loci and Targetable Pathogenic Pathways
Cordell H, Han Y, Mells G, Li Y, Hirschfield GM, Greene CS, Xie G, Juran BD, Zhu D, Qian DC, Floyd JAB, Morley KI, Prati D, Lleo A, Cusi D, Canadian-US PBC Consortium, Italian PBC Genetics Study Group, UK-PBC Consortium, Gershwin ME, Anderson CA, Lazaridis KN, Invernizzi P, Seldin MF, Sandford RN, Amos CI, Siminovitch K. International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways. Nature Communications 2015, 6: 8019. Copyright: © 2015 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ DOI link to article: http://dx.doi.org/10.1038/ncomms9019 Date deposited: 01/10/2015 This work is licensed under a Creative Commons Attribution 4.0 International License Newcastle University ePrints - eprint.ncl.ac.uk ARTICLE Received 30 Jan 2015 | Accepted 3 Jul 2015 | Published 22 Sep 2015 DOI: 10.1038/ncomms9019 OPEN International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways Heather J. Cordell1, Younghun Han2, George F. Mells3, Yafang Li2, Gideon M. Hirschfield4, Casey S. Greene5, Gang Xie6, Brian D. Juran7, Dakai Zhu2, David C. Qian2, James A.B. -
PDU Case Report XXXX/YY Date
planning report D&P/3147/01 5 March 2014 100 Whitechapel Road Land and Building Fronting Fieldgate Street & Vine Court, London, E1 1JG in the London Borough of Tower Hamlets planning application no. PA/13/03049 Strategic planning application stage 1 referral Town & Country Planning Act 1990 (as amended); Greater London Authority Acts 1999 and 2007; Town & Country Planning (Mayor of London) Order 2008 The proposal Demolition of existing vehicle workshop and erection of extension to the prayer hall at the East London Mosque, residential development comprising 241 open market and affordable housing units including studio, one, two, three and four bedroom apartments in buildings up to 18 storeys, basement parking, public realm improvements, pedestrian link from Fieldgate Street to Whitechapel Road. The applicant The applicant is Alyjiso and Fieldgate Ltd. and the architect is Webb Gray. Strategic issues The development of this mixed-use scheme accommodates both the extension of the East London Mosque and residential uses on a constrained site within the City Fringe Opportunity Area. The proposal is broadly in accordance with strategic planning policy, and is supported. However, further discussion is required regarding housing quality, children’s play space provision, inclusive design, sustainability and transport. Recommendation That Tower Hamlets Council be advised that while the application is generally acceptable in strategic planning terms the application does not comply with the London Plan, for the reasons set out in paragraph 86 of this report; but that the possible remedies set out in this paragraph could address these deficiencies. Context 1 On the 20 January 2014 the Mayor of London received documents from Tower Hamlets Council notifying him of a planning application of potential strategic importance to develop the above site for the above uses. -
Medical Students in England and France, 1815-1858
FLORENT PALLUAULT D.E.A., archiviste paléographe MEDICAL STUDENTS IN ENGLAND AND FRANCE 1815-1858 A COMPARATIVE STUDY University of Oxford Faculty of Modern History - History of Science Thesis submitted for the degree of Doctor in Philosophy Trinity 2003 ACKNOWLEDGMENTS In the first instance, my most sincere gratitude goes to Dr Ruth Harris and Dr Margaret Pelling who have supervised this thesis. Despite my slow progress, they have supported my efforts and believed in my capacities to carry out this comparative study. I hope that, despite its defects, it will prove worthy of their trust. I would like to thank Louella Vaughan for providing an interesting eighteenth-century perspective on English medical education, sharing her ideas on my subject and removing some of my misconceptions. Similarly, I thank Christelle Rabier for her support and for our discussions regarding her forthcoming thesis on surgery in England and France. My thanks naturally go to the staff of the various establishments in which my research has taken me, and particularly to the librarians at the Wellcome Library for the History and Understanding of Medicine in London, the librarians in the History of Science Room at the Bibliothèque nationale de France in Paris, and to Bernadette Molitor and Henry Ferreira-Lopes at the Bibliothèque Inter-Universitaire de Médecine in Paris. I am grateful to Patricia Gillet from the Association d’entraide des Anciens élèves de l’École des Chartes for the financial support that the Association has given me and to Wes Cordeau at Texas Supreme Mortgage, Inc. for the scholarship that his company awarded me. -
Davenant Foundation School Foundation School
DAVENANT DAVENANT FOUNDATION SCHOOL FOUNDATION SCHOOL Chester Road, Loughton, Essex IG10 2LD. Telephone: 020 8508 0404 Facsimile: 020 8508 9301 E-mail: [email protected] Twitter: @DavenantFS @Davenant6thform “a community based firmly on Christian principles” Ofsted “parental commitment and support are significant factors in the school’s success” Ofsted “the school’s extra curricular provision is particularly strong” Ofsted www.davenantschool.co.uk Nurturing Mind, Body and Spirit Produced by: The School Brochure Specialist, FM Litho Design and Print. Tel: 01787 479479 • [email protected] • www.fmlitho.co.uk DAVENANT “a Christian school valuing the past with a vision of the future” It has been over fifty years since Davenant moved from Whitechapel to our present site, here in Loughton. The school has grown to be a highly regarded, Christian ecumenical school achieving excellent results for students of all abilities. Students, staff and the wider community work very hard to make Davenant a successful school. We see ourselves as a community that promotes individual excellence and nurtures the God given potential within each of us. Our ethos is based firmly on the commitment to “nurture mind, body and spirit” and, therefore, we work hard to ensure each student not only achieves their academic potential but also has a range of opportunities to be enriched and to enjoy new experiences away from the classroom. Also, Davenant is highly regarded for the work done in training and developing teachers so that our students receive the high quality teaching they deserve. Our expectations of each other are high. We demand a great deal of our students-hard work, the desire to learn, a determination to succeed and a willingness to contribute fully to the life of the school. -
SAVED by the BELL ! the RESURRECTION of the WHITECHAPEL BELL FOUNDRY a Proposal by Factum Foundation & the United Kingdom Historic Building Preservation Trust
SAVED BY THE BELL ! THE RESURRECTION OF THE WHITECHAPEL BELL FOUNDRY a proposal by Factum Foundation & The United Kingdom Historic Building Preservation Trust Prepared by Skene Catling de la Peña June 2018 Robeson House, 10a Newton Road, London W2 5LS Plaques on the wall above the old blacksmith’s shop, honouring the lives of foundry workers over the centuries. Their bells still ring out through London. A final board now reads, “Whitechapel Bell Foundry, 1570-2017”. Memorial plaques in the Bell Foundry workshop honouring former workers. Cover: Whitechapel Bell Foundry Courtyard, 2016. Photograph by John Claridge. Back Cover: Chains in the Whitechapel Bell Foundry, 2016. Photograph by John Claridge. CONTENTS Overview – Executive Summary 5 Introduction 7 1 A Brief History of the Bell Foundry in Whitechapel 9 2 The Whitechapel Bell Foundry – Summary of the Situation 11 3 The Partners: UKHBPT and Factum Foundation 12 3 . 1 The United Kingdom Historic Building Preservation Trust (UKHBPT) 12 3 . 2 Factum Foundation 13 4 A 21st Century Bell Foundry 15 4 .1 Scanning and Input Methods 19 4 . 2 Output Methods 19 4 . 3 Statements by Participating Foundrymen 21 4 . 3 . 1 Nigel Taylor of WBF – The Future of the Whitechapel Bell Foundry 21 4 . 3 . 2 . Andrew Lacey – Centre for the Study of Historical Casting Techniques 23 4 . 4 Digital Restoration 25 4 . 5 Archive for Campanology 25 4 . 6 Projects for the Whitechapel Bell Foundry 27 5 Architectural Approach 28 5 .1 Architectural Approach to the Resurrection of the Bell Foundry in Whitechapel – Introduction 28 5 . 2 Architects – Practice Profiles: 29 Skene Catling de la Peña 29 Purcell Architects 30 5 . -
Transforming Our Research Base, Collaborative Projects Showcase
#TCNPlus TRANSFORMING OUR RESEARCH BASE: COLLABORATIVE PROJECTS SHOWCASE FERGUS HARRADENCE Deputy Director, Construction, Department for Business, Energy & Industrial Strategy ALISON NICHOLL Head of Constructing Excellence, BRE ##TCNPlusTCNPlus PUTTING PEOPLE AT THE HEART OF FUTURE SOCIAL HOUSING DESIGN AND MANUFACTURE DR HUDA DAWOOD Senior Research Associate, Teesside University PROFESSOR PAUL VAN SCHAIK Professor of Psychology, Teesside University ##TCNPlusTCNPlus THE PROBLEM • Social-housing occupants have limited choice over their living environment • Social-housing providers focus on low cost • User experience is not systematically addressed in social-housing design Existing work on requirements and design takes a technology-driven ‘deficit approach’: fixing problems rather than fulfilling human needs • Occupants’ quality of living environment may be compromised v The project addresses the lack of a systematic and theoretical approach to incorporating user experience (UX) research, tools and models to support social housing design • Social-housing occupants are more likely to experience fuel poverty v The project also focuses on occupants’ understanding and experience of energy systems #TCNPlus THE PLAN 1. Conduct a systematic literature review to identify design parameters that are relevant for housing and influence occupants’ UX 2. Conduct a systematic literature review to identify occupants’ user needs, convert these into requirements and establish their relevance 3. Develop a theoretical design matrix as a basis for subsequent -
Pacman TEMPLATE
Updated October 2019 National Cardiac Arrest Audit Participating Hospitals The total number of hospitals signed up to participate in NCAA is 194. England Birmingham and Black Country Non-participant New Cross Hospital The Royal Wolverhampton Hospitals NHS Trust Queen Elizabeth Hospital, Birmingham University Hospital Birmingham NHS Foundation Trust Participant Alexandra Hospital Worcestershire Acute Hospitals NHS Trust Birmingham Heartlands Hospital University Hospital Birmingham NHS Foundation Trust City Hospital Sandwell and West Birmingham Hospitals NHS Trust Good Hope Hospital University Hospital Birmingham NHS Foundation Trust Hereford County Hospital Wye Valley NHS Trust Manor Hospital Walsall Healthcare NHS Trust Russells Hall Hospital The Dudley Group of Hospitals NHS Trust Sandwell General Hospital Sandwell and West Birmingham Hospitals NHS Trust Solihull Hospital University Hospital Birmingham NHS Foundation Trust Worcestershire Royal Hospital Worcestershire Acute Hospitals NHS Trust Central England Participant George Eliot Hospital George Eliot Hospital NHS Trust Glenfield Hospital University Hospitals of Leicester NHS Trust Kettering General Hospital Kettering General Hospital NHS Foundation Trust Leicester General Hospital University Hospitals of Leicester NHS Trust Leicester Royal Infirmary University Hospitals of Leicester NHS Trust Northampton General Hospital Northampton General Hospital NHS Trust Hospital of St Cross, Rugby University Hospitals Coventry and Warwickshire NHS Trust University Hospital Coventry University -
13-20 Settles Street
13-20 SETTLES STREET WHITECHAPEL, LONDON E1 Freehold refurbishment opportunity 1 13–20 SETTLES STREET PROVIDES AN OPPORTUNITY TO ACQUIRE A RARE FREEHOLD PROPERTY IN AN AREA EXPERIENCING EXTRAORDINARY GROWTH. TO THE WEST ALDGATE IS BEING TRANSFORMED, TO THE NORTH THE TECH SECTOR EXPANDS FROM SHOREDITCH, AND TO THE EAST WHITECHAPEL WILL RECEIVE CROSSRAIL – JUST TWO MINUTES JOURNEY TIME FROM BOTH CANARY WHARF AND LIVERPOOL STREET. 2 3 EXECUTIVE SUMMARY • Freehold • A distinctive 1930s neo-Georgian property within the Whitechapel vision area • Excellent transport connectivity being approximately 500m from Whitechapel and Aldgate East Underground stations • The existing building comprises a net internal area of 17,107 sq ft (1,589 sq m) of office and ancillary accommodation arranged over lower ground, ground and one upper floor • Single let on an FRI lease to Trillium for Department of Work and Pensions at a rent of £150,000 per annum, expiring 1st April 2018 • The building has planning consent for a comprehensive refurbishment and addition of 3 further floors, with a proposed net internal area of 22,682 sq ft (2,107 sq m), and a change of planning use from A2 to B1 (offices) • Offers are invited in excess of £7,000,000, subject to contract and exclusive of VAT • A purchase at the level reflects a low capital value of £409 per sq ft on the existing accommodation and £308 per sq ft on the consented scheme 1 2 THE SHARD THE CITY OF LONDON TOWER OF LONDON ALDGATE ST KATHARINE DOCKS STATION BRICK LANE GOODMAN’S FIELDS SPITALFIELDS MARKET TOWER HILL STATION ALDGATE EAST STATION WHITECHAPEL STATION ROYAL LONDON HOSPITAL 3 4 LOCAL AREA Aldgate and Whitechapel are evolving to become an integral part of London’s Tech Belt. -
Capital Grant Release from the Whitechapel High Street Fund To
Commissioner Decision Report 24 May 2016 Report of: Classification: Aman Dalvi Unrestricted Corporate Director, Development and Renewal Report Title: Whitechapel High Street Fund as grant to London Small Business Centre to deliver capital refurbishment and accessible workspace at 206 Whitechapel Road (SITE 2) Originating Officer(s) Duncan Brown, Strategic Project Manager, Whitechapel Delivery Team Wards affected Whitechapel, Stepney Green, Spitalfields-and-Banglatown, Bethnal Green Key Decision? Yes Community Plan Theme A great place to live; A fair and prosperous community; A safe and cohesive community EXECUTIVE SUMMARY In July 2015, the Council entered into a jointly sponsored funding agreement known as the Whitechapel High Street Fund (WHSF) with the Greater London Authority (GLA) valued at £1.123 million to be spent in the geographical boundary of the Whitechapel Vision Masterplan SPD area by April 2017. The agreement consists of £520,000 awarded by the GLA matched by a £603,000 contribution from the Council (LBTH). Of this funding, £725,000 is allocated as capital funding for the refurbishment and reuse of vacant and underused spaces in order to contribute towards the delivery of workspace within the Whitechapel area. Of the £725,000 amount, the Council has until 30th September 2016 to allocate approximately £400,000 of unspent GLA match funding towards capital projects, or it must return these monies back to the GLA. Therefore timescales are critical to project spend being delivered within this timeframe. Following a six month pre-qualified site selection process (Call for Spaces) that commenced in September 2015 and bid selection process (Call for Bids) thereafter, this report recommends funding be released against SITE 2 (Royal Mail Group owned vacant unit at 206 Whitechapel Road) from the Whitechapel High Street Fund as grant directly towards the London Small Business Centre, to procure and deliver refurbishment works to enable new accessible workspace provision. -
Whitechapel Station Environmental Statement
Whitechapel Station Environmental Statement Non-technical Summary Contents Background to Crossrail 1 About this Document 1 Crossrail at Whitechapel 2 Existing Situation 2 The Scheme 3 Other Works at Whitechapel 7 Constructing Crossrail 8 Alternatives 9 Assessment of Environmental Impacts 10 Townscape and Built Heritage 10 Visual Amenity 10 Archaeology 11 Ecology 11 Water Resources 11 Traffic and Transport 12 Noise and Vibration 13 Air Quality 13 Contaminated Land 14 Community 14 Socio-economics 14 Cumulative Impacts 15 What Happens Next? 16 Conceptual visualisation of new Whitechapel Station Background to Crossrail About this Document Crossrail is a major railway development, connecting Maidenhead A new design has been developed for Whitechapel Station since the through central London to Shenfield and Abbey Wood. The railway publication of the Crossrail ES (2005). An Environmental Impact will also connect Heathrow Airport, the West End, central London, Assessment (EIA) has been completed for these design changes and including Whitechapel Station and Canary Wharf. an ES has been produced. In order to gain approval to build and operate the new railway, EIA is a process used at an early stage in planning and design to The Crossrail Bill was submitted to Parliament together with predict the environmental impacts of a development. It can be used to an Environmental Statement (ES) in 2005 that assessed the find ways to reduce any adverse impacts, shape projects to fit into the environmental impacts of works required for the Crossrail project. The local environment and maximise environmental benefits which could Crossrail Bill received Royal Assent and became The Crossrail Act in be created. -
Epidemiology of Visual Impairment, Sight-Threatening Or Treatment-Requiring Diabetic Eye Disease in Children and Young People in the UK: Findings from DECS
1 Title page Title: Epidemiology of visual impairment, sight-threatening or treatment-requiring diabetic eye disease in children and young people in the UK: findings from DECS. Authors: Maria C Ibanez-Bruron MD, PhD1,2,3; Ameenat L Solebo PhD, FRCOphth1,2,4,5,6; Phillippa M. Cumberland MSc1,2, Jugnoo S Rahi PhD, FRCOphth1,2,4,5,6, on behalf of the Diabetic Eye Disease in Childhood Study (DECS) group. Affiliations: 1 Great Ormond Street Institute of Child Health, University College London, London, UK 2 Ulverscroft Vision Research Group, London, UK 3 Department of Ophthalmology, Pontificia Universidad Católica de Chile, Santiago, Chile 4 Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK 5 Moorfields NIHR Biomedical Research Centre, London, UK 6 Institute of Ophthalmology, University College London, London, UK. Corresponding author: Professor Jugnoo Sangeeta Rahi, PhD, FRCOphth. GOS Institute of Child Health UCL, 30 Guildford Street, London, WC1N 1EH. Tel: 020 7905 2250; email: [email protected] ORCiD: 0000-0002-5718-9209 Word count: 3134 Financial Support: This work was funded by the Ulverscroft Foundation, the Diabetes Research & Wellness Foundation. Maria Ibanez-Bruron is also funded by National Commission for Scientific and Technological Research in Chile (CONICYT). AL Solebo 2 received support from the National Institute for Health Research Biomedical Research Centre (NIHR BRC) based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, and is funded by an NIHR Clinician Scientist award. JS Rahi receives support from the NIHR BRC based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, and is also supported by an NIHR Senior Investigator award. -
Medico-Chirurgical Transactions
MEDICO-CHIRURGICAL TRANSACTIONS. PUBLISHED BY THE ROYAL MEDICAL AND CHIIRURGICAL SOCIETY OF LONDON. VOLUME THE SIXTY-THIRD. LONDON: LONGMANS, GREEN, READER, AND DYER, PATERNOSTER ROW. 1880. i........OO.EOHTR:IJRQIOA .'.TRANSACTIONS.- THE ROYAL MEDICAL AND. CIUURGICAL SOCIETY * ~~~or LONDON. SECOND SERIES. VOLUME THE FORTY-PffmT LONDON: LONGMANS, G[REN, READER, AND DYER, PATERNOSTER ROW. 1880. PRINTED BY J. E. ADLARD, BARTHOLOXEW COSE. ROYAL MEDICAL AND CHIRURGICAL SOCIETY OF LONDON. PATRON. THE QUEEN. OFFICERS AND COUNCIL, ELECTED MARCH 1, 1880. 8resihet,t JOHN ERIC ERICHSEN, F.R.S. rCHARLES BLAND RADCLIFFE, M.D. ALFRED BARING GARROD, M.D., F.R.S. VICE-PRESIDENTS. BARNARD WIGHT HOLT. LJOHN BIRKETT. r WILLIAM WEGG, M.D. TREASURERS. l JOHN COOPER FORSTER. { REGINALD EDWARD THOMPSON, M.D. SECRETARIES. TIMOTHY HOLMES. GEORGE JOHNSON, M.D., F.R.S. LIBRARIANS. L l JOHN WHITAKER HULKE, F.R.S. r JOHN LANGDON H. DOWN, M.D. CHARLES HILTON FAGGE, M.D. SAMUEL FENVICK, M.D. JOHN HARLEY, M.D. OTHER MEMBERS J GEORGE ROPER, M.D. OF COUNCIL. ] FREDERICK JAMES GANT. CHRISTOPHER HEATH. FRANCIS MASON. JOHN MORGAN. ALFRED WILLETT. THE ABOVE FORM THE COUNCIL. RESIDENT ASSISTANT-LIBRARIAN. BENJAMIN ROBERT WHEATLEY. A LIST OF THE PRESIDENTS OF THE SOCIETY FROM ITS FORMATION. ELECTED 1805. WILLIAM SAUNDERS, M.D. 1808. MATTHEW BAILLIE, M.D. 1810. SIR HENRY HALFORD, BART., M.D., G.C.H. 1813. SIR GILBERT BLANE, BART., M.D. 1815. HENRY CLINE. 1817. WILLIAM BABINGTON, M.D. 1819. SIR ASTLEY PASTON COOPER, BART., K.C.H., D.C.L. 1821. JOHN COOKE, M.D. 1823. JOHN ABERNETHY. 1825.