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Generated by SRI International Pathway Tools Version 25.0, Authors S Authors: Pallavi Subhraveti Ron Caspi Quang Ong Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_900167095Cyc: Oceanospirillum multiglobuliferum ATCC 33336 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari phosphate thiamine phosphate ammonium ammonium cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate (2-aminoethyl) phosphate phosphate diphosphate a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid phosphonate predicted ABC RS10820 RS14810 RS15745 RS00205 RS00450 RS00210 RS01220 RS05530 transporter RS10840 RS11125 RS02005 of phosphate thiamine cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA (2-aminoethyl) phosphate ammonium ammonium phosphate phosphate diphosphate a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA phosphonate phosphate Fatty Acid and Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Lipid Degradation Macromolecule Modification protein S-nitrosylation 2-amino-6-[1-hydroxyethyl]- heptosyl- ADP-L-glycero-β- 6-methoxy-2-all- DNA combined a (3R)-3- a (3R)-3- a (3R,5Z)-3- a uracil 1498 a [protein]-L- and denitrosylation β a purine 3-(all-trans-heptaprenyl) a ribonucleoside superpathway of tetrahydrofolate biosynthesis fatty acid -oxidation I 7-methyl-7,8-dihydropterin Kdo -lipid A D-manno-heptose trans-octaprenyl- with exogenous hydroxyhexacosanoyl- hydroxydocosanoyl- hydroxydodec- in 16S rRNA β-alanine methionine ubiquinol-8 biosynthesis (prokaryotic) pyridoxal 5'-phosphate biosynthesis I lipoate biosynthesis thioredoxin pathway molybdenum cofactor biosynthesis tetrapyrrole biosynthesis 2 benzene-1,2-diol diphosphate dGDP NAD thiamine salvage I Cell Structure Biosynthesis a [protein]- 2-amino-4-hydroxy-6- ribonucleoside adenosylcobinamide lipopolysaccharide 1,4-benzoquinone bifunctional 3- DNA to form a [acp] [acp] 5-enoyl-[acp] 16S rRNA peptide- and incorporation I I (from glutamate) bifunctional 3-hydroxyacyl-[acyl- 3-hydroxyacyl-[acyl- 3-hydroxyacyl-[acyl- ribonucleoside- 4-aminobutyrate- all-trans- phosphorylation and L-cysteine a (3Z)-alk-3- hydroxymethyldihydropteridine 5'-triphosphate bifunctional heptosyltransferase demethylubiquinol 3- recombinational (uracil(1498)-N(3))- methionine (S)-S- ribonucleoside- D-erythrose demethylmenaquinone Holliday junction carrier-protein] carrier-protein] carrier-protein] diphosphate -2-oxoglutarate GTP 4-hydroxybenzoate octaprenyl an oxidized transhydrogenation thiamine peptidoglycan biosynthesis I (meso-diaminopimelate containing) enoyl-CoA diphosphokinase: adenosylcobinamide II: B5D26_RS09060 O-methyltransferase/ junction methyltransferase: oxide reductase: diphosphate 4-phosphate Glu methyltransferase/2- resolvase RuvX: dehydratase FabZ: dehydratase FabZ: dehydratase FabA: reductase transaminase: an octanoyl-[acp] thioredoxin + ATP Kdo transfer to lipid IV II reductase thiamine RS10815 thiamine 4-hydroxybenzoatediphosphate NAD A B5D26_RS11570 kinase/ lipopolysaccharide 2-polyprenyl-6- B5D26_RS11875 B5D26_RS07880 erythrose-4- glutamate--tRNA UDP-N-acetyl- methoxy-6-polyprenyl-1,4- B5D26_RS13170 B5D26_RS12730 B5D26_RS12730 B5D26_RS09765 subunit alpha: B5D26_RS08970 polyprenyltransferase: octanoyltransferase: cys 2-amino-4-hydroxy-6- adenosylcobinamide- heptosyltransferase hydroxyphenol 16S rRNA peptide- subunit alpha: GTP phosphate NAD kinase: GTP ligase: α-D-glucosamine a [protein] 3- benzoquinol methylase: crossover junction 3-hydroxyacyl-[acyl- 3-hydroxyacyl-[acyl- 3-hydroxyacyl-[acyl- B5D26_RS09265 B5D26_RS06325 B5D26_RS05025 molybdopterin- thiamine CMP-Kdo lipid IV hydroxymethyldihydropteridine phosphate II: B5D26_RS14135 methylase: (uracil(1498)-N(3))- 4-aminobutyrate- methionine (S)-S- B5D26_RS09265 cyclohydrolase 3-octaprenyl-4- a [lipoyl-carrier B5D26_RS02215 A nitrosothio- a (2E)-2- B5D26_RS13450 dehydrogenase: thioredoxin- synthase phosphate an L-glutamyl-B5D26_RS06695 UDP-N-acetylglucosamine guanylyltransferase: 3-methyl-6-methoxy- resolution of endodeoxyribonuclease carrier-protein] carrier-protein] carrier-protein] ribonucleotide- -2-oxoglutarate I FolE: protein] N 6 - NADP + L-cysteine:[protein 3-deoxy-D-manno- L-alanine long-chain fatty diphosphokinase: B5D26_RS12525 methyltransferase: oxide reductase: ribonucleotide- guanine RS05130 guanine hydroxybenzoate gapA Glu enoyl-CoA (heptosyl) - 2-octaprenyl-1,4- RuvC: B5D26_RS12445 dehydratase FabA: dehydratase FabA: dehydratase FabZ: diphosphate disulfide reductase: adenylyltransferase cysteine] GTP 3',8'-cyclase: [tRNA ] 1-carboxyvinyltransferase: octulosonic acid a 2,3,4-saturated acid--CoA ligase: B5D26_RS08630 B5D26_RS02580 ADP 2 2-methoxy-6-(all-trans recombinational B5D26_RS13190 transaminase: B5D26_RS09950 diphosphate B5D26_RS01305 octanoyl-L-lysine thiamine- a purine adenosyl- Kdo -lipid A 3 3-octaprenyl-4- 4-phospho- B5D26_RS01035 coenzyme A 3-hydroxybutyryl- a 2,3,4- [1-(2-amino-7-methyl-4-oxo- 2 benzoquinone junction B5D26_RS09765 B5D26_RS09765 B5D26_RS12730 reductase an N - B5D26_RS08720 a protein-L- 7,8- B5D26_RS13325 NAD(P)(+) MoeB: sulfurtransferase: B5D26_RS10925 phosphate kinase: transferase: fatty acid B5D26_RS00205 acyl-CoA -heptaprenyl)phenol reductase hydroxybenzoate D-erythronate lipoyl synthase: glutamyl-tRNA α CoA epimerase: saturated (3R)-3- 7,8-dihydro-3H-pteridin- ribonucleoside cobinamide a (2E)-hexacos- a (2E)-docos- a (2E,5Z)-dodeca- subunit beta: methyluracil 1498 methionine- dihydroneopterin transhydrogenase: B5D26_RS02040 B5D26_RS03090(8S)-3',8-cyclo-7,8- UDP-N-acetyl- - B5D26_RS06065 [+ 3 isozymes] dehydrogenase: formation of two 3-oxopropanoate subunit beta: decarboxylase: B5D26_RS05030 B5D26_RS13560 reductase: B5D26_RS10785 hydroxyacyl-CoA 6-yl)]ethyl diphosphate 5'-diphosphate phosphate 2-enoyl-[acp] 2-enoyl-[acp] 3,5-dienoyl-[acp] B5D26_RS09270 in 16S rRNA (S)-S-oxide a sugar RS13090 a sugar 3'-triphosphate 4-phosphoerythronate B5D26_RS05345 a carboxy-adenylated an [L-cysteine dihydroguanosine D-glucosamine- α-Kdo-(2->6)-lipid IV B5D26_RS09065 intact strands a 2'- B5D26_RS09270 B5D26_RS08930 a [lipoyl-carrier thiamine B5D26_RS02060 A a [protein]- dehydrogenase: a reduced [small subunit of desulfurase]-S- 5'-triphosphate enolpyruvate S-nitrosoglutathione [+ 8 isozymes] a 2,3,4- deoxyribonucleoside protein]-N 6 - diphosphate (S)-4-amino-5- 3-deoxy-D-manno- L-cysteine a 2,3,4-saturated GDP B5D26_RS00465 thioredoxin NADPH molybdopterin synthase] sulfanyl-L-cysteine UDP-N- saturated (3S)-3- 5'-diphosphate 2-octaprenylphenol lipoyl-L-lysine cyclic pyranopterin oxopentanoate octulosonic fatty acyl CoA (3R)-3-hydroxy-2-oxo- monophosphate acetylenolpyruvoylglucosamine S-(hydroxymethyl) Aldehyde Degradation hydroxyacyl-CoA Mo 2+ RS14250 Mo 2+ 7,8- acid kinase: 4 phosphooxybutanoate glutamate-1- reductase: B5D26_RS10600 glutathione dihydroneopterin synthase: B5D26_RS06075 3-hydroxyacyl-CoA semialdehyde- ala UDP-N-acetyl- dehydrogenase/ a (2R)-2-hydroxy a peptide with a (3R)-3- a 3-(all-trans a (3R)-3- a (3R,11Z)-3- 3'-phosphate phosphoserine B5D26_RS10915 α methylglyoxal degradation I dehydrogenase: undecaprenyl- a nascent a reduced (2R,3S)-3- a [protein]-L- a thiocarboxylated 2,1-aminomutase: α-D-muramate 4-O-phospho- - class III alcohol a peptidoglycan even numbered an N-terminal hydroxytetracosanoyl- -polyprenyl) hydroxyglutaryl- hydroxyoctadec- 3-(all-trans transaminase: cyclic pyranopterin B5D26_RS10785 diphospho-N- peptidoglycan electron-transfer UQ ATP H O dITP isopropylmalate methionine dADP + + [small subunit of B5D26_RS11510 Kdo-(2->6)-lipid IV dehydrogenase: acetyl-CoA C- with (L-alanyl- 2 K RS06405 K -octaprenyl) B5D26_RS00745 A acetylmuramoyl- UDP-N-acetyl- with (L-alanyl- straight chain flavoprotein Xaa-L-prolineXaa-Pro [acp] benzene-1,2-diol [acp] methyl ester 11-enoyl-[acp] 3-isopropylmalate peptide- phosphate B5D26_RS13115 methylglyoxal a 2,3,4-saturated acyltransferase a 2,3,4-saturated γ-D-glutamyl- electron transfer type I secretion 3-hydroxyacyl-[acyl- bifunctional 3- 3-hydroxyacyl-[acyl- 3-hydroxyacyl-[acyl- benzene-1,2-diol superpathway of thiamine diphosphate biosynthesis II molybdopterin synthase] UDP-N- L-alanyl-γ-D- α-D-glucosamine γ-D-glutamyl- 2,3,4-saturated aminopeptidase: non-canonical purine dehydratase methionine (R)-S- ribonucleoside- 4-phosphooxy- 5-aminolevulinate lactoylglutathione fatty acyl CoA FadA: 3-oxoacyl-CoA meso-2,6- long-chain fatty flavoprotein- system permease/ carrier-protein] demethylubiquinol 3- carrier-protein] carrier-protein] 7,8- bifunctional 3- acetylmuramate-- S-(hydroxysulfenamide) glutamyl-L-lysyl- undecaprenyldiphospho- meso-2,6- fatty acid B5D26_RS14680 NTP pyrophosphatase, small subunit: oxide reductase: diphosphate L-threonine molybdopterin lyase: B5D26_RS10790 diaminopimeloyl- acid--CoA ligase: ubiquinone ATPase: dehydratase FabZ: O-methyltransferase/ dehydratase FabA: dehydratase FabZ: dihydroneopterin demethylubiquinol 3- delta-aminolevulinic L-alanine ligase: -glutathione D-alanyl-D-alanine muramoylpentapeptide beta-N- diaminopimeloyl- RdgB/HAM1
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