Aldrich Aldehydes and Ketones

Total Page:16

File Type:pdf, Size:1020Kb

Aldrich Aldehydes and Ketones Aldrich Aldehydes and Ketones Library Listing – 1,311 spectra Subset of Aldrich FT-IR Spectral Libraries related to aldehydes and ketones. The Aldrich Material-Specific FT-IR Library collection represents a wide variety of the Aldrich Handbook of Fine Chemicals' most common chemicals divided by similar functional groups. These spectra were assembled from the Aldrich Collection of FT-IR Spectra and the data has been carefully examined and processed by Thermo. The molecular formula, CAS (Chemical Abstracts Services) registry number, when known, and the location number of the printed spectrum in The Aldrich Library of FT-IR Spectra are available. Aldrich Aldehydes and Ketones Index Compound Name Index Compound Name 182 ((1R)-ENDO)-(+)-3- 314 (7AS)-(+)-5,6,7,7A-TETRAHYDRO- BROMOCAMPHOR, 98% 7A- METHYL-1,5-INDANDIONE, 183 ((1S)-ENDO)-(-)-3- 99% BROMOCAMPHOR, 98% 97 (DIETHYLAMINO)ACETONE, 96% 274 (+)-3- 96 (DIMETHYLAMINO)ACETONE, 99% (TRIFLUOROACETYL)CAMPHOR, 145 (R)-(+)-3- 98% METHYLCYCLOHEXANONE, 98% 231 (+)-DIHYDROCARVONE, 98%, 135 (R)-(+)-3- MIXTURE OF ISOMERS METHYLCYCLOPENTANONE , 99% 1076 (+)-RUTIN HYDRATE, 95% 397 (R)-(+)-CITRONELLAL, 96% 830 (+)-USNIC ACID, 98% 229 (R)-(+)-PULEGONE, 98% 136 (+/-)-2,4- 248 (R)-(-)-4,4A,5,6,7,8-HEXAHYDRO- DIMETHYLCYCLOPENTANONE, 4A- METHYL-2(3H)- 99%, MIXTURE OF CIS AND TRANS NAPHTHALENONE, 97% 758 (+/-)-2- 232 (R)-(-)-CARVONE, 98% (METHYLAMINO)PROPIOPHENON 358 (S)-(+)-2- E HYDROCHLORIDE, 99% METHYLBUTYRALDEHYDE, 97% 275 (-)-3- 250 (S)-(+)-3,4,8,8A-TETRAHYDRO-8A- (TRIFLUOROACETYL)CAMPHOR, METHYL- 1,6(2H,7H)- 98% NAPHTHALENEDIONE, 9 761 (-)-LOBELINE HYDROCHLORIDE, 249 (S)-(+)-4,4A,5,6,7,8-HEXAHYDRO- 98% 4A-METHYL- 2(3H)- 151 (-)-MENTHONE, 90% NAPHTHALENONE, 97% 173 (-)-THUJONE 695 (S)-(+)-BENZOIN, 99% 179 (1R)-(+)-CAMPHOR, 98% 233 (S)-(+)-CARVONE, 96% 174 (1R)-(+)-NOPINONE, 98% 85 (S)-(+)-ERYTHRULOSE HYDRATE, 177 (1R)-(-)-FENCHONE, 98+% 97% 428 (1R)-(-)-MYRTENAL, 98% 424 (S)-(-)-PERILLALDEHYDE, TECH., 189 (1R)-(-)-THIOCAMPHOR, 97% 92% 175 (1R,2R,5R)-(+)-2-HYDROXY-3- 230 (S)-(-)-PULEGONE, 98% PINANONE, 99% 578 1'-ACETONAPHTHONE, 70% 273 (1S)-(+)-CAMPHORQUINONE, 99% 726 1'-HYDROXY-2'- 180 (1S)-(-)-CAMPHOR, 95% ACETONAPHTHONE, 99% 246 (1S)-(-)-VERBENONE, 94% (50+% 754 1,1'-(4,6-DIHYDROXY-1,3- EE/GLC) PHENYLENE)BIS- ETHANONE, 99% 474 (2,4- 119 1,1,1,2,2,3,3,7,7,8,8,9,9,9- DIMETHOXYPHENYL)ACETONE, TETRADECA- FLUORO-4,6- 98% NONANEDIONE, 97% 759 (2- 114 1,1,1,5,5,5-HEXAFLUORO-2,4- BENZOYLETHYL)TRIMETHYLAM PENTANEDIONE, 98% MONIUM IODIDE 118 1,1,1,5,5,6,6,6-OCTAFLUORO-2,4- 464 (2-FLUOROPHENYL)ACETONE, HEXANE- DIONE, TECH., 90% 99% 113 1,1,1-TRIFLUORO-2,4- 219 (2S,3S)-(+)-2-ALLYL-3-HYDROXY-2- PENTANEDIONE, 98% METHYL CYCLOPENTANONE, 95% 462 1,1,1-TRIFLUORO-3-PHENYL-2- 475 (3,4- PROPANONE, 96% DIMETHOXYPHENYL)ACETONE, 67 1,1,1-TRIFLUOROACETONE, 97% 97% 69 1,1,3,3-TETRACHLOROACETONE, 1086 (3-(3,4-DIMETHYL-9-OXO-9H- 96% THIOXANTHEN-2- YLOXY)-2- 68 1,1,3-TRICHLOROACETONE, TECH., HYDROXYPROPYL)TRIME 85% 280 (3AS,7AS)-(+)-HEXAHYDRO-3A- 65 1,1-DICHLOROACETONE, 98% HYDROXY-7A- METHYL-1,5- 453 1,1-DIPHENYLACETONE, 98% INDANDIONE, 97% 1020 1,2,3,4-TETRAFLUORO-5,8- 907 (4- DIHYDROXY- ANTHRAQUINONE, BENZOYLBENZYL)TRIMETHYLAM 99% MONIUM CHLORIDE, 95% 1087 1,2,3,4-TETRAHYDRO-9- 465 (4-FLUOROPHENYL)ACETONE, ACRIDANONE, 97% 98% (c) 2007 Thermo Fisher Scientific Inc. All rights reserved. Page 1 of 20 Aldrich Aldehydes and Ketones Index Compound Name Index Compound Name 544 1,2,3,4- 918 1,4-PHENYLENEBIS((4-(4- TETRAHYDROPHENANTHREN-1- AMINOPHENOXY)- ONE, 98% PHENYL)METHANONE), 97% 547 1,2,3,6,7,8,11,12- 1032 1,5-DIAMINOANTHRAQUINONE, OCTAHYDROBENZO(E)PYREN- 97% 9(10H)-ONE, 95% 1006 1,5-DICHLOROANTHRAQUINONE, 422 1,2,3,6- 96% TETRAHYDROBENZALDEHYDE, 86 1,5-DIHYDROXY-2,2,4,4- 99% TETRACHLORO-3-PENTANONE 263 1,2-CYCLOHEXANEDIONE, 97% HEMIHYDRATE, 98% 556 1,2-DIACETYLBENZENE, 99% 1007 1,8-DICHLOROANTHRAQUINONE, 1030 1,2-DIAMINOANTHRAQUINONE 97% 840 1,2-DIBENZOYLBENZENE, 97% 1014 1,8- 467 1,2-DIBROMO-5-METHYL-1- DIHYDROXYANTHRAQUINONE, PHENYL-3-HEXANONE 96% 968 1,2-NAPHTHOQUINONE, 97% 817 1-(2-HYDROXY-5- 571 1,3,5-TRIACETYLBENZENE, 99% METHYLPHENYL)-3-PHENYL- 1,3- 864 1,3-BIS(4- PROPANEDIONE, 97% FLUOROBENZOYL)BENZENE, 98% 816 1-(2-HYDROXYPHENYL)-3- 264 1,3-CYCLOHEXANEDIONE, 97% PHENYL-1,3- PROPANEDIONE, 98% 258 1,3-CYCLOPENTANEDIONE, 97% 821 1-(4-NITROPHENYL)-3-PHENYL-1,3- 561 1,3-DIACETYLBENZENE, 97% PROPANE- DIONE, 99% 102 1,3-DIAMINOACETONE 819 1-(5-BROMO-2- DIHYDROCHLORIDE HYDROXYPHENYL)-3-PHENYL-1,3- MONOHYDRATE, 97% PROPANEDIONE, 97% 841 1,3-DIBENZOYLBENZENE, 98% 820 1-(5-CHLORO-2-HYDROXY-4- 66 1,3-DICHLOROACETONE, 95+% METHYLPHENYL)-3- PHENYL-1,3- 75 1,3-DIHYDROXYACETONE DIMER, PROPANEDIONE, 98% 97% 818 1-(5-CHLORO-2- 454 1,3-DIPHENYLACETONE, 99% HYDROXYPHENYL)-3-PHENYL-1,3- 825 1,3-INDANDIONE, 97% PROPANEDIONE, 98% 316 1,4,4A,8A-TETRAHYDRO-ENDO-1,4- 1024 1- METHANO- NAPHTHALENE-5,8- (METHYLAMINO)ANTHRAQUINON DIONE, 98% E, 98% 557 1,4,4A,9A- 200 1-ACETYL-1-CYCLOHEXENE, 97% TETRAHYDROANTHRAQUINONE, 199 1-ACETYL-2-METHYL-1- TECH., 90% CYCLOPENTENE, 96% 682 1,4-BENZODIOXAN-6-YL METHYL 588 1-ACETYLPYRENE, 97% KETONE, 98% 130 1-ADAMANTYL BROMOMETHYL 858 1,4-BIS(4- KETONE, 98% BROMOBENZOYL)BENZENE 129 1-ADAMANTYL METHYL KETONE, 994 1,4-CHRYSENEQUINONE 99% 340 1,4-CYCLOHEXANEDIONE MONO- 1034 1-AMINO-4-BROMO-2- 2,2-DIMETHYL- TRIMETHYLENE METHYLANTHRAQUINONE, 99% KETAL, 95% 1029 1-AMINO-4- 265 1,4-CYCLOHEXANEDIONE, 98% HYDROXYANTHRAQUINONE 570 1,4-DIACETYLBENZENE, 99% 944 1-AMINO-9-FLUORENONE, 97% 103 1,4-DIAMINO-2-BUTANONE 1023 1-AMINOANTHRAQUINONE, 97% DIHYDROCHLORIDE 99% 553 1-BENZOSUBERONE, 99% 1031 1,4-DIAMINOANTHRAQUINONE, 814 1-BENZOYLACETONE, 99% 97% 486 1-BENZYL-3-PIPERIDONE 842 1,4-DIBENZOYLBENZENE, 99% HYDROCHLORIDE HYDRATE 822 1,4-DIBENZOYLBUTANE, 97% 483 1-BENZYL-3-PYRROLIDINONE, 98% 105 1,4-DIBROMO-2,3-BUTANEDIONE, 484 1-BENZYL-4-PIPERIDONE, 99% 99% 60 1-BROMO-2-BUTANONE, TECH., 1005 1,4-DICHLOROANTHRAQUINONE, 90% 97% 1285 1-BROMO-2-NAPHTHALDEHYDE, 970 1,4-NAPHTHOQUINONE HYDRATE, 99% 97% 62 1-BROMOPINACOLONE, TECH., APROX. 90% (c) 2007 Thermo Fisher Scientific Inc. All rights reserved. Page 2 of 20 Aldrich Aldehydes and Ketones Index Compound Name Index Compound Name 64 1-CHLORO-3-PENTANONE, TECH., 689 2',3',4'- 85% TRIMETHOXYACETOPHENONE, 1085 1-CHLORO-4-PROPOXY-9H- 96% THIOXANTHEN-9-ONE, 97% 654 2',4',5'- 1003 1-CHLOROANTHRAQUINONE, 98% TRIFLUOROACETOPHENONE, 99% 61 1-CHLOROPINACOLONE, 95% 730 2',4',6'- 192 1-DECALONE, 97%, MIXTURE OF TRIHYDROXYACETOPHENONE CIS AND TRANS MONOHYDRATE, 98% 322 1-DIETHYLAMINO-3-BUTANONE, 693 2',4',6'- 98% TRIMETHOXYACETOPHENONE, 98 1-DIPROPYLAMINO-2- 99% PROPANONE, 97% 575 2',4',6'- 325 1-ETHYL-3-PIPERIDONE TRIMETHYLACETOPHENONE, 98% HYDROCHLORIDE, 97% 647 2',4'-DICHLOROACETOPHENONE, 326 1-ETHYL-4-PIPERIDONE, 98% 96% 76 1-HYDROXY-2-BUTANONE, 95% 724 2',4'-DIHYDROXY-3'- 941 1-HYDROXY-9-FLUORENONE, 95% METHYLACETOPHENONE, TECH., 1010 1-HYDROXYANTHRAQUINONE 90% 518 1-HYDROXYCYCLOHEXYL 748 2',4'-DIHYDROXY-3'- PHENYL KETONE, 99% METHYLBUTYROPHENONE, 95% 524 1-INDANONE, 99+% 749 2',4'-DIHYDROXY-3'- 115 1-METHOXY-2,4-PENTANEDIONE METHYLHEXANOPHENONE, 97% 209 1-METHOXYBICYCLO(2.2.2)OCT-5- 747 2',4'-DIHYDROXY-3'- EN-2-YL METHYL KETONE, 98% METHYLPROPIOPHENONE, 98% 252 1-METHOXYMETHYL-5- 746 2',4'-DIHYDROXY-3'- NORBORNEN-2-ONE, TECH., 90% PROPYLACETOPHENONE, 99% 461 1-METHYL-2-TETRALONE, TECH., 712 2',4'-DIHYDROXYACETOPHENONE, 90% 99% 324 1-METHYL-4-PIPERIDONE, 97% 715 2',4'- 204 1-METHYL-BETA-IONONE DIHYDROXYPROPIOPHENONE, 1283 1-NAPHTHALDEHYDE, 97% 99% 485 1-PHENETHYL-4-PIPERIDONE, 98% 687 2',4'-DIMETHOXY-3'- 808 1-PHENYL-1,2-PROPANEDIONE, METHYLACETOPHENONE, 97% 99% 688 2',4'-DIMETHOXY-3'- 450 1-PHENYL-2-BUTANONE, 98% METHYLPROPIOPHENONE, 99% 1295 1-PYRENECARBOXALDEHYDE, 679 2',4'-DIMETHOXYACETOPHENONE, 99% 98% 989 10-BENZHYDRYLIDENE-9- 681 2',4'-DIMETHOXYPROPIOPHENONE ANTHRONE 573 2',4'-DIMETHYLACETOPHENONE, 960 10-BENZYLIDENEANTHRONE 96% 1293 10-CHLORO-9-ANTHRALDEHYDE, 649 2',5'-DICHLOROACETOPHENONE, 97% 98% 1089 10-METHYL-9(10H)-ACRIDONE, 643 2',5'-DIFLUOROACETOPHENONE, 99% 98% 1292 10-METHYLANTHRACENE-9- 713 2',5'-DIHYDROXYACETOPHENONE, CARBOXALDEHYDE, 96% 97% 39 10-NONADECANONE, 99% 714 2',5'- 40 11-HENEICOSANONE, 95% DIHYDROXYPROPIOPHENONE, 41 12-TRICOSANONE 98% 935 13,13'-DIBENZANTHRONYL 680 2',5'-DIMETHOXYACETOPHENONE, 42 14-HEPTACOSANONE, 97% 99% 656 2',3',4',5',6'- 574 2',5'-DIMETHYLACETOPHENONE, PENTAFLUOROACETOPHENONE, 97% 97% 642 2',6'-DIFLUOROACETOPHENONE, 655 2',3',4'- 97% TRICHLOROACETOPHENONE, 95% 710 2',6'-DIHYDROXYACETOPHENONE, 723 2',3',4'- 97% TRIHYDROXYACETOPHENONE, 678 2',6'-DIMETHOXYACETOPHENONE, 97% 98% (c) 2007 Thermo Fisher Scientific Inc. All rights reserved. Page 3 of 20 Aldrich Aldehydes and Ketones Index Compound Name Index Compound Name 606 2'- 618 2,2,2,4'- (TRIFLUOROMETHYL)ACETOPHEN TETRAFLUOROACETOPHENONE, ONE, 99% 99% 579 2'-ACETONAPHTHONE, 99% 673 2,2,2-TRIFLUORO-2',4',6'- 779 2'-AMINO-4',5'- TRIMETHOXYACETO- PHENONE, DIMETHOXYACETOPHENONE, 99% 98% 765 2'-AMINOACETOPHENONE 653 2,2,2-TRIFLUORO-2',4',6'- HYDROCHLORIDE, 95% TRIMETHYL- ACETOPHENONE, 764 2'-AMINOACETOPHENONE, 98% 98% 608 2'-BROMOACETOPHENONE, 99% 620 2,2,2-TRIFLUORO-4'- 607 2'-CHLOROACETOPHENONE, 97% (TRIFLUOROMETHYL)- 676 2'-FLUORO-4'- ACETOPHENONE, 97% METHOXYACETOPHENONE, 99% 596 2,2,2-TRIFLUOROACETOPHENONE, 604 2'-FLUOROACETOPHENONE, 97% 99% 605 2'-FLUOROPROPIOPHENONE, 98% 521 2,2,2-TRIPHENYLACETOPHENONE, 725 2'-HYDROXY-1'- 98% ACETONAPHTHONE, 99% 13 2,2,4,4-TETRAMETHYL-3- 708 2'-HYDROXY-3- PENTANONE, 98% PHENYLPROPIOPHENONE, 97% 84 2,2,5,5-TETRAMETHYL-4- 732 2'-HYDROXY-4',5'-
Recommended publications
  • Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers with Topical Pharmaceutical Agents
    Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers With Topical Pharmaceutical Agents Author Watts, Annabelle M, Cripps, Allan W, West, Nicholas P, Cox, Amanda J Published 2019 Journal Title FRONTIERS IN PHARMACOLOGY Version Version of Record (VoR) DOI https://doi.org/10.3389/fphar.2019.00294 Copyright Statement © Frontiers in Pharmacology 2019. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version. Downloaded from http://hdl.handle.net/10072/386246 Griffith Research Online https://research-repository.griffith.edu.au fphar-10-00294 March 27, 2019 Time: 17:52 # 1 REVIEW published: 29 March 2019 doi: 10.3389/fphar.2019.00294 Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers With Topical Pharmaceutical Agents Annabelle M. Watts1*, Allan W. Cripps2, Nicholas P. West1 and Amanda J. Cox1 1 Menzies Health Institute Queensland, School of Medical Science, Griffith University, Southport, QLD, Australia, 2 Menzies Health Institute Queensland, School of Medicine, Griffith University, Southport, QLD, Australia Allergic rhinitis (AR) is a chronic upper respiratory disease estimated to affect between 10 and 40% of the worldwide population. The mechanisms underlying AR are highly complex and involve multiple immune cells, mediators, and cytokines. As such, the development of a single drug to treat allergic inflammation and/or symptoms is confounded by the complexity of the disease pathophysiology. Complete avoidance of allergens that trigger AR symptoms is not possible and without a cure, the available therapeutic options are typically focused on achieving symptomatic relief.
    [Show full text]
  • Aldrich FT-IR Collection Edition I Library
    Aldrich FT-IR Collection Edition I Library Library Listing – 10,505 spectra This library is the original FT-IR spectral collection from Aldrich. It includes a wide variety of pure chemical compounds found in the Aldrich Handbook of Fine Chemicals. The Aldrich Collection of FT-IR Spectra Edition I library contains spectra of 10,505 pure compounds and is a subset of the Aldrich Collection of FT-IR Spectra Edition II library. All spectra were acquired by Sigma-Aldrich Co. and were processed by Thermo Fisher Scientific. Eight smaller Aldrich Material Specific Sub-Libraries are also available. Aldrich FT-IR Collection Edition I Index Compound Name Index Compound Name 3515 ((1R)-(ENDO,ANTI))-(+)-3- 928 (+)-LIMONENE OXIDE, 97%, BROMOCAMPHOR-8- SULFONIC MIXTURE OF CIS AND TRANS ACID, AMMONIUM SALT 209 (+)-LONGIFOLENE, 98+% 1708 ((1R)-ENDO)-(+)-3- 2283 (+)-MURAMIC ACID HYDRATE, BROMOCAMPHOR, 98% 98% 3516 ((1S)-(ENDO,ANTI))-(-)-3- 2966 (+)-N,N'- BROMOCAMPHOR-8- SULFONIC DIALLYLTARTARDIAMIDE, 99+% ACID, AMMONIUM SALT 2976 (+)-N-ACETYLMURAMIC ACID, 644 ((1S)-ENDO)-(-)-BORNEOL, 99% 97% 9587 (+)-11ALPHA-HYDROXY-17ALPHA- 965 (+)-NOE-LACTOL DIMER, 99+% METHYLTESTOSTERONE 5127 (+)-P-BROMOTETRAMISOLE 9590 (+)-11ALPHA- OXALATE, 99% HYDROXYPROGESTERONE, 95% 661 (+)-P-MENTH-1-EN-9-OL, 97%, 9588 (+)-17-METHYLTESTOSTERONE, MIXTURE OF ISOMERS 99% 730 (+)-PERSEITOL 8681 (+)-2'-DEOXYURIDINE, 99+% 7913 (+)-PILOCARPINE 7591 (+)-2,3-O-ISOPROPYLIDENE-2,3- HYDROCHLORIDE, 99% DIHYDROXY- 1,4- 5844 (+)-RUTIN HYDRATE, 95% BIS(DIPHENYLPHOSPHINO)BUT 9571 (+)-STIGMASTANOL
    [Show full text]
  • Naturally Occurring Aurones and Chromones- a Potential Organic Therapeutic Agents Improvisingnutritional Security +Rajesh Kumar Dubey1,Priyanka Dixit2, Sunita Arya3
    ISSN: 2319-8753 International Journal of Innovative Research in Science, Engineering and Technology (An ISO 3297: 2007 Certified Organization) Vol. 3, Issue 1, January 2014 Naturally Occurring Aurones and Chromones- a Potential Organic Therapeutic Agents ImprovisingNutritional Security +Rajesh Kumar Dubey1,Priyanka Dixit2, Sunita Arya3 Director General, PERI, M-2/196, Sector-H, Aashiana, Lucknow-226012,UP, India1 Department of Biotechnology, SVU Gajraula, Amroha UP, India1 Assistant Professor, MGIP, Lucknow, UP, India2 Assistant Professor, DGPG College, Kanpur,UP, India3 Abstract: Until recently, pharmaceuticals used for the treatment of diseases have been based largely on the production of relatively small organic molecules synthesized by microbes or by organic chemistry. These include most antibiotics, analgesics, hormones, and other pharmaceuticals. Increasingly, attention has focused on larger and more complex protein molecules as therapeutic agents. This publication describes the types of biologics produced in plants and the plant based organic therapeutic agent's production systems in use. KeyWords: Antecedent, Antibiotics; Anticancer;Antiparasitic; Antileishmanial;Antifungal Analgesics; Flavonoids; Hormones; Pharmaceuticals. I. INTRODUCTION Naturally occurring pharmaceutical and chemical significance of these compounds offer interesting possibilities in exploring their more pharmacological and biocidal potentials. One of the main objectives of organic and medicinal chemistry is the design, synthesis and production of molecules having value as human therapeutic agents [1]. Flavonoids comprise a widespread group of more than 400 higher plant secondary metabolites. Flavonoids are structurally derived from parent substance flavone. Many flavonoids are easily recognized as water soluble flower pigments in most flowering plants. According to their color, Flavonoids pigments have been classified into two groups:(a) The red-blue anthocyanin's and the yellow anthoxanthins,(b)Aurones are a class of flavonoids called anthochlor pigments[2].
    [Show full text]
  • Targeting Fibrosis in the Duchenne Muscular Dystrophy Mice Model: an Uphill Battle
    bioRxiv preprint doi: https://doi.org/10.1101/2021.01.20.427485; this version posted January 21, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 Title: Targeting fibrosis in the Duchenne Muscular Dystrophy mice model: an uphill battle 2 Marine Theret1#, Marcela Low1#, Lucas Rempel1, Fang Fang Li1, Lin Wei Tung1, Osvaldo 3 Contreras3,4, Chih-Kai Chang1, Andrew Wu1, Hesham Soliman1,2, Fabio M.V. Rossi1 4 1School of Biomedical Engineering and the Biomedical Research Centre, Department of Medical 5 Genetics, 2222 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada 6 2Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Minia 7 University, Minia, Egypt 8 3Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, 9 Darlinghurst, NSW, 2010, Australia 10 4Departamento de Biología Celular y Molecular and Center for Aging and Regeneration (CARE- 11 ChileUC), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, 8331150 12 Santiago, Chile 13 # Denotes Co-first authorship 14 15 Keywords: drug screening, fibro/adipogenic progenitors, fibrosis, repair, skeletal muscle. 16 Correspondence to: 17 Marine Theret 18 School of Biomedical Engineering and the Biomedical Research Centre 19 University of British Columbia 20 2222 Health Sciences Mall, Vancouver, British Columbia 21 Tel: +1(604) 822 0441 fax: +1(604) 822 7815 22 Email: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2021.01.20.427485; this version posted January 21, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder.
    [Show full text]
  • NINDS Custom Collection II
    ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC
    [Show full text]
  • 1 Abietic Acid R Abrasive Silica for Polishing DR Acenaphthene M (LC
    1 abietic acid R abrasive silica for polishing DR acenaphthene M (LC) acenaphthene quinone R acenaphthylene R acetal (see 1,1-diethoxyethane) acetaldehyde M (FC) acetaldehyde-d (CH3CDO) R acetaldehyde dimethyl acetal CH acetaldoxime R acetamide M (LC) acetamidinium chloride R acetamidoacrylic acid 2- NB acetamidobenzaldehyde p- R acetamidobenzenesulfonyl chloride 4- R acetamidodeoxythioglucopyranose triacetate 2- -2- -1- -β-D- 3,4,6- AB acetamidomethylthiazole 2- -4- PB acetanilide M (LC) acetazolamide R acetdimethylamide see dimethylacetamide, N,N- acethydrazide R acetic acid M (solv) acetic anhydride M (FC) acetmethylamide see methylacetamide, N- acetoacetamide R acetoacetanilide R acetoacetic acid, lithium salt R acetobromoglucose -α-D- NB acetohydroxamic acid R acetoin R acetol (hydroxyacetone) R acetonaphthalide (α)R acetone M (solv) acetone ,A.R. M (solv) acetone-d6 RM acetone cyanohydrin R acetonedicarboxylic acid ,dimethyl ester R acetonedicarboxylic acid -1,3- R acetone dimethyl acetal see dimethoxypropane 2,2- acetonitrile M (solv) acetonitrile-d3 RM acetonylacetone see hexanedione 2,5- acetonylbenzylhydroxycoumarin (3-(α- -4- R acetophenone M (LC) acetophenone oxime R acetophenone trimethylsilyl enol ether see phenyltrimethylsilyl... acetoxyacetone (oxopropyl acetate 2-) R acetoxybenzoic acid 4- DS acetoxynaphthoic acid 6- -2- R 2 acetylacetaldehyde dimethylacetal R acetylacetone (pentanedione -2,4-) M (C) acetylbenzonitrile p- R acetylbiphenyl 4- see phenylacetophenone, p- acetyl bromide M (FC) acetylbromothiophene 2- -5-
    [Show full text]
  • Cheminformatics Tools for Enabling Metabolomics by Yannick Djoumbou Feunang
    Cheminformatics Tools for Enabling Metabolomics by Yannick Djoumbou Feunang A thesis submitted in partial fulfillment of requirements for the degree of Doctor of Philosophy in Microbiology and Biotechnology Department of Biological Sciences University of Alberta ©Yannick Djoumbou Feunang, 2017 ii Abstract Metabolites are small molecules (<1500 Da) that are used in or produced during chemical reactions in cells, tissues, or organs. Upon absorption or biosynthesis in humans (or other organisms), they can either be excreted back into the environment in their original form, or as a pool of degradation products. The outcome and effects of such interactions is function of many variables, including the structure of the starting metabolite, and the genetic disposition of the host organism. For this reasons, it is usually very difficult to identify the transformation products as well as their long-term effect in humans and the environment. This can be explained by many factors: (1) the relevant knowledge and data are for the most part unavailable in a publicly available electronic format; (2) when available, they are often represented using formats, vocabularies, or schemes that vary from one source (or repository) to another. Assuming these issues were solved, detecting patterns that link the metabolome to a specific phenotype (e.g. a disease state), would still require that the metabolites from a biological sample be identified and quantified, using metabolomic approaches. Unfortunately, the amount of compounds with publicly available experimental data (~20,000) is still very small, compared to the total number of expected compounds (up to a few million compounds). For all these reasons, the development of cheminformatics tools for data organization and mapping, as well as for the prediction of biotransformation and spectra, is more crucial than ever.
    [Show full text]
  • Quinalizarina | C14H8O6 - Pubchem
    2/2/2021 Quinalizarina | C14H8O6 - PubChem RESUMEN COMPUESTO Quinalizarina PubChem CID 5004 Estructura 2D 3D Encuentra estructuras similares Seguridad química Environmental Irritant Hazard Hoja de datos del resumen de seguridad química de laboratorio (LCSS) Fórmula molecular C 14 H 8 O 6 quinalizarina 1,2,5,8-tetrahidroxiantraquinona 81-61-8 Sinónimos Alizarinbordeaux Alizarine Burdeos B Más... Peso molecular 272,21 g / mol Modificar Crear Fecha s 2021-01-31 2005-03-25 Quinalizarin is a tetrahydroxyanthraquinone having the four hydroxy groups at the 1-, 2-, 5- and 8-positions. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. ChEBI https://pubchem.ncbi.nlm.nih.gov/compound/Quinalizarin 1/30 2/2/2021 Quinalizarina | C14H8O6 - PubChem 1 Structures 1.1 2D Structure Chemical Structure Depiction PubChem 1.2 3D Conformer PubChem 1.3 Crystal Structures PDBe Ligand Code TXQ PDBe Structure Code 3FL5 PDBe Conformer Protein Data Bank in Europe (PDBe) https://pubchem.ncbi.nlm.nih.gov/compound/Quinalizarin 2/30 2/2/2021 Quinalizarina | C14H8O6 - PubChem 2 Names and Identifiers 2.1 Computed Descriptors 2.1.1 IUPAC Name 1,2,5,8-tetrahydroxyanthracene-9,10-dione Computed by LexiChem 2.6.6 (PubChem release 2019.06.18) PubChem 2.1.2 InChI InChI=1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H Computed by InChI 1.0.5 (PubChem release 2019.06.18) PubChem 2.1.3 InChI Key VBHKTXLEJZIDJF-UHFFFAOYSA-N Computed by InChI 1.0.5 (PubChem release 2019.06.18) PubChem 2.1.4 Canonical SMILES
    [Show full text]
  • Quinalizarin As a Potent, Selective and Cell Permeable Inhibitor of Protein
    Quinalizarin as a potent, selective and cell permeable inhibitor of protein kinase CK2 Giorgio Cozza, Marco Mazzorana, Elena Papinutto, Jenny Bain, Matthew Elliott, Giovanni Di Maira, Alessandra Gianoncelli, Mario A. Pagano, Stefania Sarno, Maria Ruzzene, et al. To cite this version: Giorgio Cozza, Marco Mazzorana, Elena Papinutto, Jenny Bain, Matthew Elliott, et al.. Quinalizarin as a potent, selective and cell permeable inhibitor of protein kinase CK2. Biochemical Journal, Port- land Press, 2009, 421 (3), pp.387-395. 10.1042/BJ20090069. hal-00479150 HAL Id: hal-00479150 https://hal.archives-ouvertes.fr/hal-00479150 Submitted on 30 Apr 2010 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Biochemical Journal Immediate Publication. Published on 11 May 2009 as manuscript BJ20090069 QUINALIZARIN AS A POTENT, SELECTIVE AND CELL PERMEABLE INHIBITOR OF PROTEIN KINASE CK2. Giorgio COZZA *, Marco MAZZORANA *† , Elena PAPINUTTO †, Jenny BAIN §, Matthew ELLIOTT §, Giovanni DI MAIRA *† , Alessandra GIANONCELLI *, Mario A. PAGANO *† , Stefania SARNO *† , Maria
    [Show full text]
  • STUDIES RELATED to the SYNTHESIS of Arylnaphthatrne LIGNANS
    1. STUDIES RELATED TO THE SYNTHESIS OF ARYLNAPHTHAtRNE LIGNANS A thesis presented by SUSAN MARY MELLOWS in partial fulfilment of the requirements for the degree of DOCTOR OF PHILOSOPHY of the UNIVERSITY OF LONDON Imperial College London S.W.7. October 1970. 2. Abstract This thesis is concerned with the synthesis o cyclolignans and in particular the synthesis of the pharmacologically active cyclolignan, podophyllotoxin. Existing syntheses of cyclolignans are reviewed. Various photochemical synthetic routes to the cyclolignans are proposed. One of these, the photoenolisation of o-benzylbenzaldehydes and subsequent Diels-Alder addition to the dienol of an appropriate dienophile has been investigated. Some general aspects of the photoenolisation reaction are discussed. Irradiation with ultra-violet light of the model compound o-tolualdehyde in the presence of dimethyl- acetylenedicarboxylate gave 2,3-dicarboxymethy1-1,4- -dihydro-l-naphthol. Cis-C1,C2-cis-C2,C3-l-tetralol- -2,3-dicarboxylic anhydride was formed by photoenolisation of o-tolualdehyde in the presence of maleic anhydride. Metal hydride reduction of the maleic anhydride adduct gave a mixture of cis-C1,C2-cis-C2,C3-2-carboxy-3-hydroxy- methyl-l-tetralo1-2,3'--lactone and cis-C1,C2-cis-C2,C3- 3-carboxy-2-hydroxymethyl-l-tetralo1-2',3-6'-lactone. gn acid catalysed rearrangement of the maleic anhydride adduct gave cis-C1,C2-cis-C2,C3-2,3-dicarboxy-l-tetralo1- 4-lactone which was reduced with diborane to cis-C1,C2- -cis-C2,C3-37carboxy-2-hydroxymethyl-l-tetralo1-2' ,3- - 3 • lactone. The synthesis of 6-(3,k,5-trimethoxybenzyl)piperonal is reported.
    [Show full text]
  • Cystathionine-Β-Synthase: Molecular Regulation and Pharmacological Inhibition
    biomolecules Review Cystathionine-β-synthase: Molecular Regulation and Pharmacological Inhibition Karim Zuhra 1 , Fiona Augsburger 1 , Tomas Majtan 2 and Csaba Szabo 1,* 1 Chair of Pharmacology, Section of Medicine, University of Fribourg, 1702 Fribourg, Switzerland; [email protected] (K.Z.); fi[email protected] (F.A.) 2 Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; [email protected] * Correspondence: [email protected] Received: 14 April 2020; Accepted: 27 April 2020; Published: 30 April 2020 Abstract: Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (a cytotoxic molecule and cardiovascular risk factor) and the generation of hydrogen sulfide (H2S), a gaseous biological mediator with multiple regulatory roles in the vascular, nervous, and immune system. CBS is up-regulated in several diseases, including Down syndrome and many forms of cancer; in these conditions, the preclinical data indicate that inhibition or inactivation of CBS exerts beneficial effects. This article overviews the current information on the expression, tissue distribution, physiological roles, and biochemistry of CBS, followed by a comprehensive overview of direct and indirect approaches to inhibit the enzyme. Among the small-molecule CBS inhibitors, the review highlights the specificity and selectivity problems related to many of the commonly used “CBS inhibitors” (e.g., aminooxyacetic acid) and provides a comprehensive review of their pharmacological actions under physiological conditions and in various disease models. Keywords: hydrogen sulfide; cancer; Down syndrome; pharmacology; homocysteine; cystathionine 1.
    [Show full text]
  • Tepzz 77889A T
    (19) TZZ T (11) EP 2 277 889 A2 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 26.01.2011 Bulletin 2011/04 C07K 1/00 (2006.01) C12P 21/04 (2006.01) C12P 21/06 (2006.01) A01N 37/18 (2006.01) (2006.01) (2006.01) (21) Application number: 10075466.2 G01N 31/00 C07K 14/765 C12N 15/62 (2006.01) (22) Date of filing: 23.12.2002 (84) Designated Contracting States: • Novozymes Biopharma UK Limited AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Nottingham NG7 1FD (GB) IE IT LI LU MC NL PT SE SI SK TR (72) Inventors: (30) Priority: 21.12.2001 US 341811 P • Ballance, David James 24.01.2002 US 350358 P Berwyn, PA 19312 (US) 28.01.2002 US 351360 P • Turner, Andrew John 26.02.2002 US 359370 P King of Prussia, PA 19406 (US) 28.02.2002 US 360000 P • Rosen, Craig A. 27.03.2002 US 367500 P Laytonsville, MD 20882 (US) 08.04.2002 US 370227 P • Haseltine, William A. 10.05.2002 US 378950 P Washington, DC 20007 (US) 24.05.2002 US 382617 P • Ruben, Steven M. 28.05.2002 US 383123 P Brookeville, MD 20833 (US) 05.06.2002 US 385708 P 10.07.2002 US 394625 P (74) Representative: Bassett, Richard Simon et al 24.07.2002 US 398008 P Potter Clarkson LLP 09.08.2002 US 402131 P Park View House 13.08.2002 US 402708 P 58 The Ropewalk 18.09.2002 US 411426 P Nottingham 18.09.2002 US 411355 P NG1 5DD (GB) 02.10.2002 US 414984 P 11.10.2002 US 417611 P Remarks: 23.10.2002 US 420246 P •ThecompletedocumentincludingReferenceTables 05.11.2002 US 423623 P and the Sequence Listing can be downloaded from the EPO website (62) Document number(s) of the earlier application(s) in •This application was filed on 21-09-2010 as a accordance with Art.
    [Show full text]