Mast Cell Leukemia
European Journal of Haematology ORIGINAL ARTICLE Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor Sophie Georgin-Lavialle1,2,3, Ludovic Lhermitte2,4,*, Felipe Suarez5,*, Ying Yang6,7,Se´ bastien Letard6,7, Katia Hanssens6,7, Fre´ de´ ric Feger2, Ame´ de´ e Renand2, Chantal Brouze4, Danielle Canioni1,8, Vahid Asnafi4, Marie-Olivia Chandesris1,5, Achille Aouba5, Paul Gineste9, Elizabeth Macintyre4, Colin D. Mansfield9, Alain Moussy9, Yves Lepelletier2, Patrice Dubreuil6,7, , Olivier Hermine1,2,5, 1Centre de Re´ fe´ rence des Mastocytoses, Faculte´ de Me´ decine et AP-HP Necker-Enfants Malades; 2CNRS UMR 8147, Hoˆ pital Necker-Enfants malades; 3Service de Me´ decine Interne, Hoˆ pital Europe´ en Georges Pompidou, Universite´ Paris Descartes, Paris Sorbonne Cite´ , Assistance Publique-Hoˆ pitaux de Paris; 4Laboratoire d’he´ matologie Biologique et UMR CNRS 8147, Universite´ Paris Descartes, Paris Sorbonne Cite´ , Faculte´ de Me´ decine et AP-HP Necker-Enfants Malades; 5Service d’He´ matologie Adultes, Universite´ Paris Descartes, Paris Sorbonne Cite´ , Faculte´ de Me´ decine et AP-HP Necker-Enfants Malades, Paris; 6INSERM U891, Centre de Recherche en Cance´ rologie de Marseille, Laboratoire de Signalisation, He´ matopoı¨e` se et Me´ canisme de l’Oncogene` se, Centre de re´ fe´ rence des Mastocytoses; 7Institut Paoli-Calmettes, Marseille, France; Univ Me´ diterrane´ e, Marseille; 8Laboratoire d’anatomopathologie, Universite´ Paris Descartes, Paris Sorbonne Cite´ , Faculte´ de Me´ decine et AP-HP Necker-Enfants Malades; 9AB Science, 3 avenue Georges V, Paris, France Abstract Objective: Most patients with systemic mastocytosis bear mutations in the tyrosine kinase receptor gene c-Kit.
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