64th Annual Scientific Meeting

SOCIETYFINAL FOR REPRODUCTIVE PROGRAM INVESTIGATION

D2D: DATA TO DISCOVERY

MARCH 15-18, 2017 HILTON ORLANDO BONNET CREEK 14100 BONNET CREEK RESORT LANE – ORLANDO, FL 32821

Continuing Medical Education credit is provided through joint providership with The American College of Obstetricians and Gynecologists. Table of Contents Message from SRI President...... 3 2017 Program Committee...... 4 Schedule-at-a-Glance...... 5 SRI Underrepresented Minority Program...... 6 About Orlando...... 7 Social Events ...... 8 Exhibitors...... 9 Hilton Orlando Bonnet Creek Floor Plan...... 10 Continuing Medical Education Information...... 11 Scientific Program...... 12 Poster Guide...... 51 Thank You to Our 2017 Poster Judges...... 87 SRI Grants Program...... 88 Save the Date: SRI-University of Edinburgh Symposium...... 89 SRI Awards...... 90 About SRI...... 92 SRI Council & Staff...... 94 SRI Thanks 2017 Supporters...... 95 Save the Date: SRI 2018 Annual Meeting...... Back Cover

64th SRI Annual Scientific Meeting Venue Hilton Orlando Bonnet Creek 14100 Bonnet Creek Resort Lane Orlando, FL 32821 Phone: +1-407-597-3600

Future SRI Meetings SRI 65th Annual Scientific Meeting • San Diego, CA • March 7-10, 2018 SRI 66th Annual Scientific Meeting • Paris, France • March 13-16, 2019 SRI 67th Annual Scientific Meeting • Vancouver, Canada • March 11-14, 2020

Society for Reproductive Investigation 555 East Wells Street, Suite 1100, Milwaukee, WI 53202-3823 Phone: +1-414-918-9888 • Fax: +1-414-276-3349 Email: [email protected] •Website: www.sri-online.org © Society for Reproductive Investigation. All rights reserved. SRI-0117-228

2 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Message from SRI President

Welcome Dear Colleagues: Welcome to the 64th Annual Meeting of the Society for Reproductive Investigation, March 15 - 18, 2017 in Orlando, FL. The theme of the 2017 meeting, “D2D: Data to Discovery,” was chosen to highlight new basic, translational and clinical approaches and opportunities for harnessing the power of scientific data to promote knowledge in reproductive health and medicine. Sam Mesiano, PhD, as Program Director, has created an excellent program, which includes three Presidential Distinguished Lecturers, one trainee plenary session, 24 concurrent oral sessions, 12 mini-symposia and two special symposia. In addition to the scientific sessions, we have also planned complementary events that advance the mission of SRI. The first is Connection Corners, an annual event that engages trainees with the more experienced members of the Society. We will also hold three lunch sessions – on Wednesday, we will hold a Diversity Career Development Forum; on Thursday, the topic will be Systems Biology in Pregnancy Health and Research; on Friday, the focus will be Precision Medicine and Women’s Health. Each of our three Presidential Distinguished Lectures represents a different aspect of our D2D theme. The Thursday Presidential lecturer is Suchi Saria, PhD, from the Department of Computational Sciences at Johns Hopkins University. Dr Saria is an expert in computational biology and machine learning. She applies her unique knowledge to computational health informatics and predictive modeling in healthcare. The Friday Presidential lecturer is Stephen Quake, PhD, Lee Otterson Professor in the School of Engineering and Professor of Bioengineering, Applied Physics and Physics at Stanford University. Dr Quake’s recent inventions in the area of prenatal genomics have transformed the field. He will share his innovative research and provide visionary comments about the future of blood based-genomic testing. David Haig, PhD, George Putnam Professor of Organismic and Evolutionary Biology at Harvard University, will give the Saturday Presidential lecture. Dr. Haig will talk about his novel and provocative data synthesis approaches to understanding maternal-fetal conflict. The 2017 annual meeting will be held in Orlando, FL, at the Hilton Orlando Bonnet Creek. The science will be stimulating, the camaraderie will be engaging, and the warm sun of Florida will be shining. On behalf of the SRI Council, officers and staff, I invite you to attend the exciting meeting we have planned and connect with our colleagues and friends in SRI! Yours,

Yoel Sadovsky, MD, SRI President 2016-2017

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 3 2017 Program Committee

2017 Program Committee Program Committee Chair Program Committee Co-Chair Stephen Matthews, PhD Emre Seli, MD University of Toronto Yale University 2017 Program Director Sam Mesiano, PhD Case Western Reserve University

Elizabeth A. Bonney, MD, MPH Sarah England, PhD University of Vermont Washington University William H. Catherino, MD, PhD Leslie Myatt, PhD Uniformed Services University Oregon Health & Science University Marilyn Cipolla, PhD Bo Rueda, PhD University of Vermont Harvard Medical School Sandra T. Davidge, PhD Emiel Post Uiterweer, MD, PhD University of Alberta UMC Utrecht Charles Ducsay, PhD Stacy Zamudio, PhD Loma Linda University Hakensack University Yoel Sadovsky, MD Magee-Women’s Research Institute

4 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Schedule-at-a-Glance

Schedule-at-a-Glance

TUESDAY, WEDNESDAY, THURSDAY, FRIDAY, SATURDAY, MARCH 14 MARCH 15 MARCH 16 MARCH 17 MARCH 18 7:00 a.m. – 7:00 p.m. 7:00 a.m. – 6:00 p.m. 7:00 a.m. – 6:30 p.m. 7:00 a.m. – 1:00 p.m. Registration Registration Registration Registration

7:30 a.m. – 8:30 a.m. 8:00 a.m. – 10:00 a.m. 7:15 a.m. – 8:00 a.m. 8:00 a.m. – 9:00 a.m. Career Development President’s Welcome SRI Business President’s Session – Mid- Address, President’s Meeting (Members Distinguished Career Researcher Distinguished only) (Breakfast Lecture III Breakfast Lecture I, New provided) 9:00 a.m. – 10:30 a.m. Investigator Plenary 8:30 a.m. – 5:00 p.m. 8:00 a.m. – 9:00 a.m. Poster Session III Satellite Meetings 10:00 a.m. – 11:30 a.m. President’s

Morning 10:30 a.m. – 12:00 p.m. Poster Session I Distinguished Concurrent Oral Lecture II Presentations IV 9:15 a.m. – 10:45 a.m. Concurrent Oral Presentations II

10:45 a.m. – 12:15 p.m. Poster Session II 2:00 p.m. – 7:00 p.m. 8:30 a.m. – 5:00 p.m. 12:00 p.m. – 1:30 p.m. 12:30 p.m. – 2:00 p.m. 12:15 p.m. – 1:45 p.m. Registration Satellite Meetings Special Symposia I Special Symposia II Hot Topics & Awards Ceremony 2:00 p.m. – 6:00 p.m. 12:00 p.m. – 1:00 p.m. 12:00 p.m. – 1:30 p.m. 12:30 p.m. – 2:00 p.m. SRI Council Career Development Past President’s Pfizer – SRI (Lunch Included) Meeting Session - Diversity Lunch (Invitation President’s Awards 2:00 p.m. – 4:00 p.m. Symposium Only) Lunch (By Invitation SRI Council Meeting

12:00 p.m. – 1:00 p.m. 1:45 p.m. – 3:45 p.m. Only) Reproductive Mini Symposia I 2:15 p.m. – 3:45 p.m.

Afternoon Sciences Editorial 3:45 p.m. – 4:00 p.m. Concurrent Oral Board Meeting Coffee Break Presentations III

4:00 p.m. – 6:00 p.m. 3:45 p.m. – 4:00 p.m. Concurrent Oral Coffee Break Presentations I 4:00 p.m. – 6:00 p.m. Mini Symposia II 5:15 p.m. – 6:45 p.m. 6:15 p.m. – 7:45 p.m. 6:15 p.m. – 7:45 p.m. Career Development Connection Corners Presidential Session – In – Address, Awards and Training and Early Wine and Cheese Career Researcher Reception Evening 6:45 p.m. – 8:00 p.m. Welcome Reception

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 5 SRI Underrepresented Minority Program

SRI Underrepresented Minority Program

To both encourage global participation and further diversify the Annual Scientific Meeting, SRI is pleased to offer to the below individuals discounted registration as part of SRI’s Reduced Registration Program for Underrepresented Minorities! These individuals are underrepresented in their country or originate from a low-income, lower-middle-income, or upper-middle-income country (as defined by the World Bank). Applications for this program will open along with Annual Meeting registration each year, and more details can be found on the SRI website. Congratulations to the following: Fernanda Alvarado, MD, Guatemala Emmanuel Amabebe, PhD, Nigeria Bryan Ampey, PhD, USA Fatima Barragan, Mexico Zahirrah Begam Mohamed Rasheed, MSc, Malaysia Jimena Beltrame, Argentina Violeta Castro Leyva, PhD, Mexico Marcel Chuecos Rincon, Venezuela Tania Gonzalez, PhD, USA Samir Gorasiya, Nigeria Prosper Igboeli, MD, Nigeria Güínever Império, MD, Brazil Jasmine Johnson, MD, USA Toluwalope Junaid, MBChB, Nigeria Edwina Kisanga, Sudan Clarence Manuel, USA Carmel Martin-Fairery, PhD, USA Bruno Meza Lopez Bayghen, Mexico Alina Montalbano, PhD, Mexico Siti Aminah Muhammad Imran, Malaysia Mercedes Olaya, MD, PhD, Colombia Daniela Pino, MD, Venezuela Maria Rabaglino, PhD, Argentina Mila Reginatto, MD, Argentina Fernando Reis, MD, PhD, Brazil Maria Laura Ribeiro, PhD, Argentina Maria Salazar Garcia, MD, Mexico Arianna Smith, PhD, USA Micaela Sordelli, PhD, Argentina Gerialisa Van Gronigen Caeser, USA Jessica Vazquez, USA Rodolfo Vicetti Miguel, MD, Peru Rosalina Villalon Landeros, USA Lu Zong, MD, China

6 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL About Orlando

About Orlando Orlando, a city in central Florida, is home to more than a dozen theme parks. Chief among its claims to fame is Walt Disney World, comprised of 4 parks, including Magic Kingdom and Epcot, and 2 water parks. Another major player, Universal Orlando, offers 2 parks: Universal Studios and Islands of Adventure, with the Wizarding World of Harry Potter straddling both. March Weather: Average High: 78°F, 25°C; Average Low: 54°F, 12°C Local time: Eastern Standard Time Population: 255,483 (2013) Source: www.google.com

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 7 Social Events & Exhibitors

Social Events Welcome Reception Wednesday, March 15, 2017 – 6:45 p.m. - 8:00 p.m. Signature Island Join us for socializing, drinks and light appetizers. Connection Corners Thursday, March 16, 2017 – 6:15 p.m. - 7:45 p.m. Bonnet Creek Pavilion, lower level tented space New, Early Career and Mid-Career Investigators are invited to come meet and connect with Senior Investigators about jobs, career advice or just some friendly banter. Drinks and light appetizers provided.

8 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Exhibitors Look for our Exhibitors in the poster hall, Bonnet Creek I – XI. Lina Medical USA, Inc. 1856 Corporate Drive, Suite 135 Norcross, GA 30093 Phone: +1-770-218-6800 Email: [email protected] www.linamed.com Reproductive Scientist Development Program (RSDP) Washington University School of Medicine 425 South Euclid Avenue Campus Box 8064, BJC-IH, 10th Floor St. Louis, MO 63110 Phone: +1-314-747-0264 Email: [email protected] www.rsdp.wustl.edu University of Hawai’i Biorepository John A. Burns School of Medicine 651 Ilalo Street, BSB 222 Honolulu, HI 96813 Phone: +1-808-692-1797 www.uhbio.jabsom.hawaii.edu

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 9 Hilton Orlando Bonnet Creek Floor Plan

Hilton Orlando Bonnet Creek Floor Plan

Lobby Level

HILTON ORLANDO BONNET CREEK HILTON ORLANDO BONNET CREEK BONNET CREEK BALLROOM FLORIDIAN BALLROOM Office

HILTON ORLANDO BONNET CREEK HILTON ORLANDO BONNET CREEK BONNET CREEK BALLROOM FLORIDIAN BALLROOM Office

Posters & Exhibits Session Rooms Plenary Room

Lower LevelPosters & Exhibits Session Rooms Plenary Room

HILTON ORLANDO BONNET CREEK MEETING ROOMS

HILTON ORLANDO BONNET CREEK MEETING ROOMS

Speaker Ready Room (De Soto)

Signature Island

10 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Continuing Medical Education Information

Continuing Medical Education Purpose Provide an opportunity for physicians to receive updated information and solidify their knowledge of reproductive sciences and women’s health. Target Audience Physicians and scientists who are involved in the evaluation and/or care of patients requiring reproductive health care. Participants should be clinicians or scientists who have backgrounds in the fields of obstetrics, perinatology, reproductive genetics, gynecology and gynecologic oncology, endocrinology, reproductive physiology, biochemistry, pharmacology, immunology, epidemiology, reproductive infectious disease, reproductive stem cell and developmental biology. Learning Objectives At the completion of the activity participants should be able to: • Describe key research findings in big data acquisition and application in reproductive sciences and women’s health. • Recognize the translational value of new research (especially big data application) to women’s health and personalized medicine. • Understand the underlying pathophysiology of key areas of reproductive sciences and women’s health. ACCME Accreditation This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The American College of Obstetricians and Gynecologists and the Society for Reproductive Investigation. The American College of Obstetricians and Gynecologists is accredited by the ACCME to provide continuing medical education for physicians.

AMA PRA Category 1 Credit(s)™ The American College of Obstetricians and Gynecologists designates this live activity for a maximum of 18 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. College Cognate Credit(s) The American College of Obstetricians and Gynecologists designates this live activity for a maximum of 18 Category 1 College Cognate Credits. The College has a reciprocity agreement with the AMA that allows AMA PRA Category 1 CreditsTM to be equivalent to College Cognate Credits.

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 11 Scientific Program

Scientific Program

Wednesday, March 15 Tuesday, March 14 2:00 p.m. - 7:00 p.m. Registration BONNET CREEK FOYER 2:00 p.m. - 6:00 p.m. SRI Council Meeting MANATEE Wednesday, March 15 7:00 a.m. - 7:00 p.m. Registration 7:30 a.m. - 8:30 a.m. Career Development Session – Mid-Career Researcher (Breakfast served at 7:00 a.m.) FLORIDIAN E-F Navigating a Changing Landscape: Mid-Career in Reproductive Science Moderators: Elizabeth A. Bonney, MD, MPH Jared Robins, MD Changes in both medicine and science have created unique challenges and opportunities for a mid-career professional in reproductive science. The purpose of this event is to bring together those who consider themselves at mid-career to 1) define these challenges and opportunities and 2) determine what steps need to be taken and what resources need to be developed or leveraged to meet these challenges and assist mid-career professionals to continue or refine their career paths. The discussion content will be developed into a white paper to be shared in the SRI journal, Reproductive Sciences. 8:30 a.m. - 5:00 p.m. Endometrium Satellite Meeting FLORIDIAN C Endometriomics in Health and Disease Organizers: Peter A.W. Rogers, PhD University of Melbourne Asgi T. Fazleabas, PhD Michigan State University Morning Session: 8:30 a.m. - 12:00 p.m. 8:30a.m. - 9:30 a.m Mouse Models for Uncovering Estrogen and ER Actions in the Uterus Kenneth S. Korach, PhD National Institute of Environmental Health Sciences/ National Institute of Health 9:30 a.m. - 10:00 a.m. Break 10:00 a.m. - 10:30 a.m. Steroid Hormone-Epigenome Interplay in the Human Endometrium Sahar Houshdaran, PhD University of California, San Francisco 10:30 a.m. - 11:00 a.m. The Endometrial Cistrome: Identifying Novel Targets of the Glucocorticoid Receptor Shannon D. Whirledge, PhD Yale School of Medicine 12 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Wednesday, March 15, continued 11:00 a.m. - 12:00 p.m. Roles of Non-Coding RNA in Endometrial-Embryo Interactions Eva Dimitriadis, PhD Hudson Institute of Medical Research 12:00 p.m. - 1:30 p.m. Lunch Afternoon Session: 1:30 p.m. - 5:00 p.m. 1:30 p.m. - 2:30 p.m. Addressing Neglected Diseases: Innovative Ways to Relieve Women From

the Burden of Endometriosis 15 March Wednesday, Markus Koch, PhD Bayer AG 2:30 p.m. - 3:00 p.m. Profiling Endometrial Pericytes Reveals Roles in Endometrial Repair Phoebe Kirkwood, PhD Student MRC Centre for Inflammation Research, University of Edinburgh 3:00 p.m. - 3:30 p.m. Decidualization Defect as a Possible Maternal Cause of Preeclampsia Tamara Garrido, PhD University of Valencia, Igenomix/INCLIVA 3:30 p.m. - 4:00 p.m. Break 4:00 p.m. - 5:00 p.m. Obesity, Decidualization and Autophagy - The Perfect Storm Kelle Moley, MD Washington University 8:30 a.m. - 5:00 p.m. Fetal Physiology Satellite Meeting BONNET CREEK X Integration of Environmental Signals During Development Organizer: Sean W. Limesand, PhD University of Arizona Morning Session: 8:20 a.m. - 12:00 p.m. Moderator: Sean W. Limesand, PhD 8:20 a.m. - 8:30 a.m. Welcome 8:30 a.m. - 9:30 a.m. Hypoxia Stress, and Fetal Inflammation: What’s the Microbiome Got to Do With It? Charles E. Wood, PhD University of Florida 9:30 a.m. - 10:00 a.m. Break 10:00 a.m. - 11:00 a.m. Developmental Programming by IUGR: Common Outcomes and Gaps in Knowledge From Animal Models Kathryn L. Gatford, PhD University of Adelaide

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Wednesday, March 15 Wednesday, March 15, continued 11:00 a.m. - 12:00 p.m. Lactocrine Signaling and the Maternal Environmental Continuum Frank “Skip” F. Bartol, PhD Auburn University 12:00 p.m. - 1:30 p.m. Lunch Afternoon Session: 1:30 p.m. - 5:00 p.m. Moderator: Dustin T. Yates, PhD University of Nebraska-Lincoln 1:30 p.m. - 2:00 p.m. Modulation of Fetal Adipogenesis by Endocrine Disrupting Chemicals Almudena Veiga-Lopez, DVM, PhD Michigan State University 2:00 p.m. - 2:30 p.m. Amino Acids Regulate Paracrine Signaling and Development of the Pancreatic Islet in IUGR Fetuses Paul J. Rozance, MD Children’s Hospital Colorado 2:30 p.m. - 3:00 p.m. Intrauterine Inflammation and Infection: Journey to Center of the Fetal Brain Irina Burd, MD, PhD Johns Hopkins Medicine International Collaborative Ovine Network (ICON) Session International Collaborative Ovine Network was established to promote sheep as a valuable animal model for biomedical and physiological research. Organizer: Matthew Kemp, PhD University of Western Australia 3:00 p.m. - 3:30 p.m. The Artifical Placenta: Development and Application Masatoshi Saito, MD, PhD Tohoku University Hospital 3:30 p.m. - 4:00 p.m. Break 4:00 p.m. - 4:30 p.m. Ultrasound in Preclinical Models of Pregnancy Sarah Stock, MBChB, PhD University of Edinburgh 4:30 p.m. - 5:00 p.m. Manipulating Gene Expression in the Sheep Placenta Russ Anthony, PhD Colorado State University

14 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Wednesday, March 15, continued 8:30 a.m. - 5:00 p.m. Myometrium/Parturition Satellite Meeting FLORIDIAN B Organizers: Rachel Tribe, PhD King’s College London R. Ann Word, MD University of Texas Southwestern Medical Center Morning Session: 8:30 a.m. - 12:00 p.m. Moderator: Rachel Tribe, PhD

King’s College London 15 March Wednesday, 8:30a.m. - 9:00 a.m. Heat Shock Proteins: Renaissance Molecules for the Myometrium Daniel MacPhee, PhD University of Saskatchewan 9:00 a.m. - 9:30 a.m. The Uterine Unfolded Protein Response Regulates Gestational Length Jennifer Condon, PhD Wayne State University School of Medicine 9:30 a.m. - 10:00 a.m. Break 10:00 a.m. - 10:30 a.m. Regulation of Inflammation and Innate Immune Cells in Preterm Birth Karen Racicot, PhD Michigan State University College of Medicine 10:30 a.m. - 11:00 a.m. The Role of Adrenomedullin in Establishing and Maintaining the Maternal-Fetal Interface Brooke Matson, MD, PhD University of North Carolina at Chapel Hill 11:00 a.m. - 11:30 a.m. Epigenetic Sensitization to African American Commensal Bacteria in Preterm Labor Scott Walsh, PhD Virginia Commonwealth University 11:30 a.m. - 12:00 p.m. TrpV4 Channels and Preterm Labour Cristina Alvira, MD Stanford University 12:00 p.m. - 1:30 p.m. Lunch Afternoon Session: 1:30 p.m. - 5:00 p.m. Moderator: R. Ann Word, MD University of Texas Southwestern Medical Center 1:30 p.m. - 2:30 p.m. Mechanisms of Dysfunctional Quiescence in Spontaneous Preterm Labor Ian Buxton, PhD University of Nevada

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 15 Scientific Program

Wednesday, March 15 Wednesday, March 15, continued 2:30 p.m. - 3:00 p.m. New Paradigms in Cervical Tissue Structure and Function Joy Vink, MD Columbia University Medical Center 3:00 p.m. - 3:30 p.m. Optical and Mass Spectral Analysis of the Cervix During Pregnancy Jeff Reese, MD Vanderbilt University 3:30 p.m. - 4:00 p.m. Break 4:00 p.m. - 5:00 p.m. Hypoxia and Myometrial Function: Something Old and Something New Susan Wray, PhD University of Liverpool 8:30 a.m. - 5:00 p.m. Ovarian Biology Satellite Meeting FLORIDIAN A Biomarkers of Embryo Viability and Implantation in the Era of Precision Medicine Organizers: Richard T. Scott, MD, Reproductive Medicine Associates New Jersey Emre Seli, MD Yale School of Medicine Morning Session: 8:30 a.m. - 12:00 p.m. Moderator: Emre Seli, MD Yale School of Medicine Non-Invasive Strategies for Embryo Assessment 8:30 a.m. - 9:30 a.m. Non-Invasive Strategies to Assess Embryo Viability Emre Seli, MD Yale School of Medicine 9:30 a.m. - 10:00 a.m. Break Invasive Strategies for Embryo Assessment 10:00 a.m. - 11:00 a.m. Pre-Implantation Genetic Screening (PGS) for Aneuploidy: Promises and Pitfalls Richard T. Scott, MD Reproductive Medicine Associates New Jersey 11:00 a.m. - 11:30 a.m. Next Generation Sequencing for Embryo Diagnostics Dagan Wells, PhD Oxford University 11:30 a.m. - 12:00 p.m. Mitochondrial DNA Copy Number as a Predictor of Embryo Implantation Elpida Fragouli, PhD Oxford University 12:00 p.m. - 1:30 p.m. Lunch

16 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Wednesday, March 15, continued Afternoon Session: 1:30 p.m. - 5:00 p.m. Moderator: Richard T. Scott, MD Reproductive Medicine Associates New Jersey Endometrial Predictors of ART Outcome 1:30 p.m. - 2:30 p.m. Transcriptomic Assessment of Endometrial Receptivity: ERA Testing Carlos Simon, MD, PhD Fundacion IVI

2:30 p.m. - 3:00 p.m. Endometrial Microbiome and Assisted Reproduction 15 March Wednesday, Jason Franasiak, MD Reproductive Medicine Associates New Jersey 3:00 p.m. - 3:30 p.m. Endometrial Proteome as a Predictor of Implantation Francisco Dominguez, PhD Fundacion IVI 3:30 p.m. - 4:00 p.m. Break Big Data and Personalized Reproductive Medicine 4:00 p.m. - 4:30 p.m. Using Prediction Model-Based Clinical Solutions to Expand Patients’ Access to IVF and PGS and Improve IVF Success Rates Mylene Yao, MD Univfy 4:30 p.m. - 5:00 p.m. Big-Data Analytics and Genomics to Optimize Infertility Treatment Mark Adams, PhD Celmatix 8:30 a.m. - 5:00 p.m. Placental Association of the Americas Satellite Meeting BONNET CREEK XI Organizer: Thomas Jansson, MD, PhD University of Colorado Anschutz Medical Campus Supported by NICHD IR13H084096 Session 1: 8:30 a.m. - 12:00 p.m. Moderators: Johann Urschitz, PhD University of Hawaii Thomas Jansson, MD, PhD University of Colorado Anschutz Medical Campus Utero-Placental Gene-Targeting In Vivo: From Mice to Humans 8:30a.m. - 9:30 a.m. Lentiviral Vector-Mediated Placenta-Specific Gene Manipulation in Mice Masahito Ikawa, PhD Osaka University 9:30 a.m. - 10:00 a.m. Break

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Wednesday, March 15 Wednesday, March 15, continued 10:00 a.m. - 10:30 a.m. PiggyBac Transposase-Mediated Gene Modulation in the Placenta Johann Urschitz, PhD University of Hawaii 10:30 a.m. - 11:00 a.m. Nano-Particle Mediated Placental IGF-1 Therapy in IUGR Helen N. Jones, PhD Cincinnati Children’s Hospital Medical Center 11:00 a.m. - 12:00 p.m. Uterine Artery Adenovirus-Mediated Delivery of VEGF to Improve Utero-Placental Flow in IUGR Anna David, PhD University College London 12:00 p.m. - 1:30 p.m. Lunch Session 2: 1:30 p.m. - 4:30 p.m. Moderators: Anna Euser, MD, PhD University of Colorado Thaddeus G. Golos, PhD University of Wisconsin-Madison Zika and the Placenta 1:30 p.m. - 2:15 p.m. Mechanisms of Antiviral Defense at the Maternal-Fetal Interface Carolyn Coyne, PhD University of Pittsburgh 2:15 p.m. - 3:00 p.m. Zika GO: Tracking ZIKV in the Placenta Indira Mysorekar, PhD Washington University 3:00 p.m. - 3:30 p.m. Zika Virus Infects Human Placental Macrophages Rana Chakraborty, MD Emory University 3:30 p.m. - 4:00 p.m. Break 4:00 p.m. - 4:30 p.m. Transplacental Innate Immune Defense and Transmission of ZIKV Jennifer Stencel-Baerenwald, PhD University of Washington Session 3: 4:30 p.m. - 5:00 p.m. Moderator: Leslie Myatt, PhD, FRCOG Oregon Health and Science University The Human Placental Project: An Update 4:30 p.m. - 5:00 p.m. The Human Placenta Project: Progress and Future Directions David Weinberg, PhD NICHD

18 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Wednesday, March 15, continued 8:30 a.m. - 5:00 p.m. Preterm Birth International Satellite Symposium BONNET CREEK XII Preterm Birth International Collaborative (PREBIC) Organizer: Ramkumar Menon, PhD University of Texas Medical Branch at Galveston Morning Session: 8:30 a.m. - 12:00 p.m. Moderators: Hanns Helmer, MD President - PREBIC

Medical University Vienna 15 March Wednesday, 8:30 a.m. - 9:00 a.m. Placental Aging and Stillbirth Professor Roger Smith, AM. MBBS, Hons., PhD, FRACP, FRANZCOG, FSRB University of Newcastle 9:00 a.m. - 9:30 a.m. Clocks, Alarms and the Onset of Parturition Robert N. Taylor, MD, PhD Wake Forest School of Medicine 9:30 a.m. - 10:00 a.m. Coffee Break 10:00 a.m. - 10:30 a.m. Novel Targets for Preventing Spontaneous Preterm Birth Martha Lappas, PhD University of Melbourne 10:30 a.m. - 11:00 a.m. Infection, Inflammation and Preterm Birth: Pharmacological Prevention and Treatment Strategies Jeffrey Keelan, PhD University of Western Australia PREBIC Keynote Lecture 11:00 a.m. - 11:45 a.m. Cell Fate Diversity and Aging Judith Campisi, PhD University of Southern California 11:45 a.m. - 12:00 p.m. Discussion 12:00 p.m. - 1:30 p.m. Lunch Afternoon Session: 1:30 p.m. - 5:00 p.m. Moderator: Nanbert Zhong, MD, PhD Secretary General, PREBIC New York State Institute for Basic Research in Developmental Disabilities 1:30 p.m. - 2:00 p.m. New Generation Biomarkers for Early (1st/2nd Trimester) and Late (3rd Trimester) Risk Prediction of Preterm Birth and its Mechanism Carl P. Weiner, MD, MBA University of Kansas School of Medicine

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Wednesday, March 15 Wednesday, March 15, continued 2:00 p.m. - 2:30 p.m. Evaluation of the Systemic Inflammatory Response Associated to Air Pollutants Exposure During Pregnancy Felipe Vadillo-Ortega, MD Instituto Nacional de Medicina Genomica 2:30 p.m. - 3:00 p.m. Cell-Based Non-Invasive Prenatal Testing Using Fetal Cells Isolated From Maternal Blood Ripudaman Singh, PhD, MBA ARCEDI Biotech ApS Progesterone Debate 3:00 p.m. - 3:30 p.m. Progesterone - Exploiting its Action to Prevent Preterm Birth Sam Mesiano, PhD Case Western Reserve University 3:30 p.m. - 4:00 p.m. Coffee Break 4:00 p.m. - 4:20 p.m. Progesterone - Why it Still Has a Role in Preterm Birth Prevention Cynthia Gyamfi-Bannerman, MD, MSc Columbia University 4:20 p.m. - 4:45 p.m. Progesterone - Why We Shouldn’t Depend on it to Prevent Preterm Birth Jane E. Norman, MD, FRCOG, FRCPE, FMedSci University of Edinburgh MRC Centre for Reproductive Health, Queen’s Medical Research Institute 4:45 p.m. - 5:00 p.m. Discussion 12:15 p.m. - 1:15 p.m. Career Development Session – Diversity Maps Where Children Matter FLORIDIAN E-F Marie Lynn Miranda, PhD Rice University This talk will cover how geospatial health informatics can be used to elucidate the role of social and environmental stressors in shaping outcomes for pregnant women and children. 12:00 p.m. - 1:00 p.m. Reproductive Sciences Editorial Board Meeting PALM BEACH 5:15 p.m. - 6:45 p.m. New Investigator Career Development Forum – In Training & Early Career Investigators Job Search and Negotiation FLORIDIAN A 5:15 p.m. - 5:20 p.m. Welcome Yolanda Smith, MD, MS

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Wednesday, March 15, continued 5:20 p.m. - 5:35 p.m. Introduction and Objectives Sascha Drewlo, PhD 5:35 p.m. - 5:45 p.m. Negotiation Process Roleplay Marie Lynn Miranda, PhD Hugh Taylor, MD 5:45 p.m. - 6:00 p.m. Discussion: The Good, the Bad, and the Ugly Side of Negotiating Sascha Drewlo, PhD 6:00 p.m. - 6:30 p.m. Panel Discussion with Drs. Drewlo, Miranda, Smith and Taylor 6:30 p.m. - 6:45 p.m. Question and Answer 6:45 p.m. - 8:00 p.m. Welcome Reception SIGNATURE ISLAND Join us for socializing, drinks and light appetizers.

Thursday, March 16 7:00 a.m. - 6:00 p.m. Registration

BONNET CREEK FOYER 16 Thursday, March 8:00 a.m. - 10:00 a.m. President’s Welcome Address, President’s Distinguished Lecture I, New Investigator Plenary FLORIDIAN D-I 8:00 a.m. - 8:10 a.m. Welcome Address Yoel Sadovsky, MD SRI President, 2016 - 2017 8:10 a.m. - 9:00 a.m. President’s Distinguished Lecture I Leveraging “Big Data” for Individualized Care Eligible for 1.0 AMA PRA Category 1 Credits™/ 1.0 Category 1 College Cognate Credits Suchi Saria, PhD Assistant Professor, Department of Computational Sciences Johns Hopkins University 9:00 a.m. - 10:00 a.m. New Investigator Plenary Session Moderators: Yoel Sadovsky, MD Sandra Davidge, PhD 9:00 a.m. – 9:15 a.m. MiR-200b Mediates the Teratogenic Effect of Maternal Diabetes Leading to Neural Tube Defects by Suppressing Autophagy and Inducing Endoplasmic Reticulum Stress Daoyin Dong, PhD

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Thursday, March 16, continued 9:15 a.m. – 9:30 a.m. SOX17 Governs the Indian Hedgehog to Promote Female Fertility via Uterine Epithelial-Stromal Interactions Xiaoqiu Wang, PhD 9:30 a.m. – 9:45 a.m. Cervical Gene Delivery of Human Beta-Defensin- 3(HBD-3) Prevents Ascending Bacterial Infection in Pregnant Mice Natalie Suff, PhD Student 9:45 a.m. – 10:00 a.m. Maternal Lifestyle Impairs Embryonic Growth: A Prospective Periconception Cohort Study Matthijs R. Van Dijk, MD Thursday, March 16 10:00 a.m. - 11:30 a.m. Poster Session I BONNET CREEK I-IX 12:00 p.m. - 1:30 p.m. Special Symposia I: Systems Biology in Pregnancy Health and Research FLORIDIAN D-I Moderators: Mark Chance, PhD Nathan Price, PhD 12:00 p.m. - 12:30 p.m. Network Biology Tools for Translational Research Mark Chance, PhD 12:30 p.m. - 1:00 p.m. Systems Analysis of OMICS Data in Pregnancy Conditions Nathan Price, PhD 1:00 p.m. - 1:30 p.m. Genestation: A Powerful Platform for Integrating Diverse Types of OMICS Data to Understand Pregnancy and its Pathologies Antonis Rokas, PhD 1:45 p.m. - 3:45 p.m. Mini Symposia I The Influence of Circadian Rhythms on Reproductive Outcomes BONNET CREEK X Eligible for 2.0 AMA PRA Category 1 Credits™/ 2.0 Category 1 College Cognate Credits Moderator: Sarah K. England, PhD 1:45 p.m. - 2:15 p.m. The Influence of Chronodisruption on Risk of Preterm Birth Sarah K. England, PhD 2:15 p.m. - 2:45 p.m. The Ability of Light to Suppress Contractions in Late-Term Pregnant Women; Mechanisms for Melatonin Action in the Human Uterus Elizabeth B. Klerman, MD, PhD 2:45 p.m. - 3:15 p.m. Circadian Rhythms in the Fetus Claudia Torres-Farfan, PhD

22 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Thursday, March 16, continued 3:15 p.m. - 3:45 p.m. Estrogenic Modulation of Activity Rhythms in Development and Adulthood Megan M. Mahoney, PhD Fundamental and Translational Aspects of Extracellular Vesicles: Focus on the Female Reproductive System BONNET CREEK XI Eligible for 2.0 AMA PRA Category 1 Credits™/2.0 Category 1 College Cognate Credits Moderator: Thomas E. Spencer, PhD 1:45 p.m. - 2:15 p.m. Extracellular Vesicles and Ovarian Function and Disease Lane Christenson, PhD 2:15 p.m. - 2:45 p.m. Extracellular Vesicles as Important Mediators of Uterine Function Thomas Spencer, PhD 2:45 p.m. - 3:15 p.m. Human Endometrial Exosomes Influence Trophectodermal Cells to Promote Implantation Lois Salamonsen, PhD 3:15 p.m. - 3:45 p.m. EXRNAs as Biomarkers for Placental Dysfunction Louise C. Laurent, MD, PhD Thursday, March 16 Thursday, March Fetal Membrane Weakening and Rupture-Understanding PPROM in Four Dimensions FLORIDIAN B Eligible for 2.0 AMA PRA Category 1 Credits™/2.0 Category 1 College Cognate Credits Moderator: John Moore, MD 1:45 p.m. - 2:15 p.m. Preterm Premature Rupture of Membranes - Clinical Perspectives Brian Mercer, MD 2:15 p.m. - 2:45 p.m. Novel Targets for Inhibition of Inflammation for the Prevention of PPROM Martha Lappas, PhD 2:45 p.m. - 3:15 p.m. Deformation and Rupture of Fetal Membranes - Microstructural Mechanisms Which May Account for Their Toughness or Brittleness Edoardo Mazza, PhD 3:15 p.m. - 3:45 p.m. Insight Gained From a Human In-Vitro Model System of Fetal Membrane Weakening Deepak Kumar, MD The -OMICs Revolution in Understanding of Uterine Leiomyomas, and the Future of Therapy BONNET CREEK XII Eligible for 2.0 AMA PRA Category 1 Credits™/2.0 Category 1 College Cognate Credits Moderator: William H. Catherino, MD, PhD

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 23 Scientific Program

Thursday, March 16, continued 1:45 p.m. - 2:15 p.m. The Genetics and Genomics of Leiomyomas William H. Catherino, MD, PhD 2:15 p.m. - 2:45 p.m. Developmental Epigenetics and Uterine Fibroids Ayman Al-Hendy, MD, PhD 2:45 p.m. - 3:15 p.m. Pathogenesis and Etiology of Uterine Fibroids: Opportunities for Research James Segars, MD 3:15 p.m. - 3:45 p.m. What is Effective Fibroid Treatment? Elizabeth Stewart, MD An Applied System Biology Approach to Study the Endometrial Receptivity

Thursday, March 16 FLORIDIAN A Eligible for 2.0 AMA PRA Category 1 Credits™/2.0 Category 1 College Cognate Credits Moderator: Jose Antonio Horcajadas, PhD 1:45 p.m. - 2:15 p.m. The Transcriptomics of the Endometrium: A 15 Year Data Experience Jose Antonio Horcajadas, PhD 2:15 p.m. - 2:45 p.m. The Proteomic Interactome of the Endometrial Receptivity Francisco Dominguez, PhD 2:45 p.m. - 3:15 p.m. A System Biology Approach to Understand the Endometrium’s Physiology and the Endometrial Receptivity Andres Salumets, PhD 3:15 p.m. - 3:45 p.m. Endometrial Receptivity Tests: Advanced Molecular Tools to Study the Endometrial Receptivity Sergio C. Oehninger, MD, PhD Delineating Contributors to the Genesis and/or Treatment Resistance Properties of Gynecologic Cancers FLORIDIAN C Eligible for 2.0 AMA PRA Category 1 Credits™/2.0 Category I College Cognate Credits Moderator: Bo R. Rueda, PhD 1:45 p.m. - 2:15 p.m. Unbiased Molecular Analysis of Progesterone Receptor Action in Cancer Identifies Novel Mechanisms and Processes J. Julie Kim, PhD 2:15 p.m. - 2:45 p.m. Clinicopathologic Significance of Mismatch Repair Defects in Endometrial Cancer and Promise for Immune Checkpoint Blockade- Based Therapies Paul Goodfellow, PhD

24 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Thursday, March 16, continued 2:45 p.m. - 3:15 p.m. Epithelial Cell Plasticity and the Origins of Ovarian Cancer Barbara Vanderhyden, PhD 3:15 p.m. - 3:45 p.m. Ovarian Cancer Stem Cells Display Resistance to PARP Inhibitor Treatment Bo R. Rueda, PhD 3:45 p.m. - 4:00 p.m. Coffee Break BONNET CREEK I-IX 4:00 p.m. - 6:00 p.m. Concurrent Oral Presentations I Clinical Perinatology I BONNET CREEK X Moderators: Deepak Kumar, MD Jeff Reese, MD 4:00 p.m. - 4:15 p.m. Non-Invasive Assessment of Fetal CMV Infection and Injury via Fetal Neuronal Exosomes: A Non- Human Primate Model Laura Goetzl, Nune Darbinian, Nana Merabova, Kinari Patel, Alice F. Tarantal, Peter A. Barry 4:15 p.m. - 4:30 p.m. The New Triple I Classification Scheme and

Outcomes Among Term Infants 16 Thursday, March Christina A. Herrera, Julie Shakib, Erin A.S. Clark, Michael W. Varner, Bob Silver 4:30 p.m. - 4:45 p.m. Network Analysis of Maternal Genes Implicated in Preterm-Birth Maria Schmoll, Ravindu Gunatilake, Avinash Patil, Annabeth Barnard 4:45 p.m. - 5:00 p.m. FuturebirthTM Prediction by 12w of Future Preterm Birth (PTB)<33w Using a Novel Test of Cell Free Plasma (cfp) RNA Carl Weiner, Helen Zhou, Howard Cuckle, Argyro Syngelaki, Kypros Nicolaides, Yafeng Dong 5:00 p.m. - 5:15 p.m. Altered Acylcarnitine Metabolism in the Placenta in Spontaneous Preterm Birth Summer Elshenawy, Paschalis T. Doulias, Samuel Parry, Michael Bennett, Harry Ischiropolous, Rebecca A. Simmons 5:15 p.m. - 5:30 p.m. PreImplantation Factor (PIF*) Prevents Fetal Loss by Modulating LPS Induced Inflammatory Response Martin Mueller, Nicoletta Di Simone, Fiorella Di Nicuolo, Riccardo Marana, Roberta Castellani, Francesco Ria, Manuela Veglia, Giovanni Scambia, Daniel Surbek, Eytan Barnea

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Thursday, March 16, continued 5:30 p.m. - 5:45 p.m. Genetic Deficiency in IL-6 Modifies Sex-Related Differences in Neonatal Mouse Mortality in Response to Influenza Infection Elizabeth A. Bonney, Jenna E. McQuesten, Kendall Krebs, Mercedes Rincon 5:45 p.m. - 6:00 p.m. Healthy, Infection-Free Growth of Preterm Lambs Maintained with Ex-Vivo Uterine Environment (EVE) Therapy for One Week Haruo Usuda, Shimpei Watanabe, Eleanor Woodward, Masatoshi Saito, Gabrielle C. Musk, Suhas G. Kallapur, Judith Rittenschober-Bohm, Hideyuki Ikeda, Shinichi Sato, Takushi Thursday, March 16 Hanita, Tadashi Matsuda, John P. Newnham, Matthew W. Kemp Endometriosis, Fibroids and Gynecology I FLORIDIAN B Moderators: Richard O. Burney, MD, MSc Robert N. Taylor, MD, PhD 4:00 p.m. - 4:15 p.m. GATA6 Confers an Immunologic Phenotype in Endometriosis Christia Angela M. Sison, Matthew T. Dyson, Serdar Bulun 4:15 p.m. - 4:30 p.m. Role of the Wnt Pathway in Endometriosis Maik Obendorf, Juliane Hundt, Eva Simon, Raif Lesche, Rene Wenzl, Lorenz Kuessel, Thomas M. Zollner 4:30 p.m. - 4:45 p.m. Prostaglandin E2 Signaling, Estrogen-Dominance and Progesterone-Resistance in Endometriosis Joe A. Arosh, JeHoon Lee, Kaylon L. Bruner-Tran, Kevin G. Osteen, Sakhila K. Banu 4:45 p.m. - 5:00 p.m. Endometriosis Inherently Increases the Number of CD146/CD140b Double Positive Cells in the Eutopic Endometrium of Baboons with Induced Disease Fatima Barragan, Michael R. Strug, Ren-Wei Su, Amanda Patterson, Asgerally Fazleabas 5:00 p.m. - 5:15 p.m. P2X3 - A Highly Innovative Target for the Non- Hormonal Treatment of Endometriosis A. Davenport, N. Brauer, A. Rotgeri, A. Rottmann, M. Koch, T.M. Zollner, A. Steinmeyer, J. Nagel, F. Machet, A. Coelho, S. Boyce, L. Bone, M. Gemkow, N. Carty, M. Hermann, S. Hess, I. Neagoe, O.M. Fischer 5:15 p.m. - 5:30 p.m. Progesterone and KLF11 Mediate Sexually Dimorphic Fibrotic Responses Chandra C. Shenoy, Ye Zheng, Tiffanny L. Jones, Zaraq Khan, Gaurang S. Daftary

26 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Thursday, March 16, continued 5:30 p.m. - 5:45 p.m. RPLP1 is a Novel Target of miR-451a Whose Expression is Elevated in Endometriotic Lesion Tissue and Correlates with Endometriotic Lesion Tissue and Cell Proliferation Zahraa Alali, Tommaso Falcone, Warren B. Nothnick 5:45 p.m. - 6:00 p.m. Expression Quantitative Trait Loci (eQTL) Approaches for Understanding the Genetics of Endometriosis Peter A.W. Rogers, Sarah J. Holdsworth-Carson, Jenny N. Fung, Eliza M. Colgrave, Premila Palva, Jane E. Girling, Grant W. Montgomery Maternal Biology and Health FLORIDIAN C Moderators: Kirk P. Conrad, MD Dean Myers, PhD 4:00 p.m. - 4:15 p.m. Fetal Microchimerism by Mode of Delivery in Healthy Term Gestations Raj Shree, J.L. Nelson, Sami B. Kanaan, Alexandra Forsyth, Emma Cousin, Hilary S. Gamill

4:15 p.m. - 4:30 p.m. Association Between the a2 Isoform of Vacuolar 16 Thursday, March ATPase and Markers of Inflammation in Peripheral Blood Mononuclear Cells from Pregnant Women Tomi T. Kanninen, Giovanni Sisti, Aswathi Jayaram, Steven R. Inglis, Ashwini Pandit, Steven S. Witkin 4:30 p.m. - 4:45 p.m. Unique Innate Lymphoid Cells Revealed by Machine Learning/Dimensionality Reduction in Human Decidua Jessica Vazquez, Yan Li, Aleksandar K. Stanic 4:45 p.m. - 5:00 p.m. Placental Growth Factor (Pigf) Blunts the Vascualr Response to Angiotensin II: A Novel Mechanism for Vascular Regulation During Pregnancy Jimmy Espinoza, Ancizar Betancourt, Karin Fox, Alireza Abdollah Shmshirsaz, Chandra Yallampalli 5:00 p.m. - 5:15 p.m. Leptin Receptors During the Ovarian Cycle and Pregnancy: Angiogenesis in Uterine Artery Endothelial Cells Vladmir E. Vargas, Rosalina Villalon Landeros, Gladys E. Lopez, Jing Zhen, Ronald R. Magness 5:15 p.m. - 5:30 p.m. Venoarterial Signaling (VAS) Modulates Shear Stress-Induced Gestational Uterine Artery Expansive Remodeling Nga Ling Ko, Maurizio Mandala, Liam V. John, Adama Aja, George J. Osol

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 27 Scientific Program

Thursday, March 16, continued 5:30 p.m. - 5:45 p.m. Pregnancy-Specific Estrogen Receptor-Mediated

Upregulation of Endothelial AT2, Receptor Jay Mishra, Kathirvel Gopalakrishnan, Gary Hankins, Sathish Kumar 5:45 p.m. - 6:00 p.m. The Association Between the History of Hypertensive Disorders of Pregnancy, Obesity and Hypertension in Later Life by Age Group: A Cross- Sectional Analysis Maiko Wagata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Hirohito Metocki, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Shinichi Kurlyama, Atshush Hozawa, Thursday, March 16 Junichi Sugawara Parturition I BONNET CREEK XII Moderators:Terry Morgan, MD, PhD Roger Smith, AM, MBBS, FRACP, PhD 4:00 p.m. - 4:15 p.m. The Host Defence Peptide Cathelicidin Mediates Inflammatory Preterm Birth Tina Baker, Heather MacPherson, Kirsten Wilson, Sara Rinaldi, Lorraine Frew, Adrian Thomson, Carmel Moran, Julia Dorin, Donald Davidson, Sarah J. Stock 4:15 p.m. - 4:30 p.m. Protease Amplification of the Inflammatory Response Induced by L. Iners: Implications for Racial Disparities in Preterm Birth Sheikh M.K. Alam, William H. Nugent, Sonya L. Washington, Kimberly K. Jefferson, Jerome F. Strauss III, Scott W. Walsh 4:30 p.m. - 4:45 p.m. Vaginal Dysbiosis Increases Risk of Preterm Membrane Rupture, Funisitis and Neonatal Sepsis Richard G. Brown, Yun S. Lee, Anne Smith, Lyndsay Kindinger, Julian R. Marchesi, Phillip R. Bennettt, David A. MacIntyre 4:45 p.m. - 5:00 p.m. hCG Suppresses IP-10 in Human Decidua Through Histone Methylation Michelle Silasi, Yang Yang-Hartwich, Gil Mor, Rosanna Ramhorst, Esteban Grasso 5:00 p.m. - 5:15 p.m. Relationship Between Yeast, Vaginal Microbiota Composition and Pregnancy Outcomes Holly Lewis, Pamela Pruski, Lindsay Kindinger, Yun Lee, Phillip Bennett, Zoltan Takats, David A. MacIntyre 5:15 p.m. - 5:30 p.m. Nur77, a Novel Player in Perinatal Neuroinflammation Associated with Preterm Labor in a Murine Model (Mus Musculus) Sarah Estrada, Andrew Thagard, Irina Burd, Peter Napolitano, Nicholas Ieronimakis 28 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Thursday, March 16, continued 5:30 p.m. - 5:45 p.m. Effects of Receptor for Advanced Glycation End-Products (RAGE) on Inflammation Induced Preterm Birth and Neonatal Viability in a Genetically Engineered Mouse Model Bethany T. Stetson, Brian A. Kellert, Hanaa Motawea, Megan Locke, Guomao Zhao, Antonette T. Dulay, Catalin S. Buhimschi, Irina A. Buhimschi 5:45 p.m. - 6:00 p.m. T-Cell Activation-Induced Preterm Labor Involves Unique Innate and Adaptive Immune Responses That Differ from Those Observed in Inflammation- and Progesterone Withdrawal-Induced Preterm Labor Marcia Arenas-Hernandez, Roberto Romero, Tara N. Mial, Felipe Vadillo-Ortega, Sonia S. Hassan, Nardhy Gomez-Lopez Preeclampsia I BONNET CREEK XI Moderators: Justyna Dopierala, PhD Norman Gant, MD 4:00 p.m. - 4:15 p.m. Targeted Nanoparticle Delivery of Short Interfering

RNAs to Treat Preeclampsia 16 Thursday, March Natalie J. Hannan, Scott Pattison, Sally Beard, Natalie K. Binder, Jennifer MacDiarmid, Himanshu Brahmbhatt, Tu’uhevaha J. Kaitu’u-Lino, Stephen Tong 4:15 p.m. - 4:30 p.m. Hydrogen Sulphide Ameliorates Preeclampsia-Like Phenotype Induced by Elevated sFlt-1 in Placenta Growth Deficiency Shakil Ahmad, Keqing Wang, Peter Hewett, Asif Ahmed 4:30 p.m. - 4:45 p.m. A Novel Conjugated Linoleic Acid Therapy for Preeclampsia Shows Protective Effects on Human Endothelial Cell Function In Vitro Danielle M. Berdahl, Dinesh M. Shah, Ian M. Bird, Derek S. Boeldt 4:45 p.m. - 5:00 p.m. Fetal Asymmetric Dimethylarginine Regulates Maternal Haemodynamics Aikaterini Georgopoulou, James Leiper, Mark R. Johnson 5:00 p.m. - 5:15 p.m. Molecular Evidence for Abnormal Differentiation of Invasive Trophoblast in Preeclampsia Anna Natenzon, Sonia DaSilva-Arnold, Stacy Zamudio, Abdulla Al-Khan, Nicholas P. Illsley 5:15 p.m. - 5:30 p.m. Role of Estrogen and Its Metabolites in Uterine Artery Endothelial Cells Migration from a Model of Unilateral Pregnant Sheep Rosalina Villalon-Landeros, Chi Zhou, Jing Zheng, Ronald R. Magness FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 29 Scientific Program

Thursday, March 16, continued 5:30 p.m. - 5:45 p.m. A Randomised Controlled Trial and Cost- Effectiveness Analysis of Low Dose Aspirin with an Early Screen Test for Preeclampsia in Low Risk Women F. Mone, C. Mulcahy, P. McParland, J. O’Mahony, E. Tyrell, F. Breathnach, C. Normand, F. Cody, J. Morrison, S. Daly, J. Higgins, A. Cotter, E. Tully, P. Dicker, Z. Alfirevic, F. Malone, F.M. McAuliffe 5:45 p.m. - 6:00 p.m. Three Protein-Truncating Mutations That May Contribute to Developing Preeclampsia H.S. Gammill, R. Chettier, A. Brewer, J.M. Roberts, R. Shree, E. Thursday, March 16 Tsigas, K. Ward Reproductive Biology I FLORIDIAN A Moderators: Zaher Merhi, MD Felice Petraglia, MD 4:00 p.m. - 4:15 p.m. Maternal MiR-30d Deficiency is Associated with Defects in Endometrial Receptivity, Embryonic Implantation and Fetal Development Nuria Balaguer, Inmaculada Moreno, Maria Herrero, Marta Gonzalez-Montfort, Carlos Simon, Felipe Vilella 4:15 p.m. - 4:30 p.m. Double Conditional Knockout of SMAD2 and SMAD3 Results in Endometrial Dysfunction, Infertility, and Uterine Cancer Maya Kriseman, Diana Monsivais, Julio Agno, Ramya Masand, William Gibbons, Martin Matzuk 4:30 p.m. - 4:45 p.m. Non-Classical Progesterone Reeptor (PGRMC1) and and SERPINE1 mRNA Binding Protein (SERBP1) Interaction Influences the Human Decidualization Process Stefania Salsano, Alicia Quinonero, Silvia Perez, Carlos Simon, Francisco Dominguez 4:45 p.m. - 5:00 p.m. Hypoxia Inducible (HIF) in the Endometrium: A Potential Therapeutic Target for Heavy Menstrual Bleeding (HMB) Jacqueline A. Maybin, Alison Murray, Nik Hirani, Philippa T.K. Saunders, Peter Carmeliet, Hilary O.D. Critchley 5:00 p.m. - 5:15 p.m. Remodeling of Deicdual Immune Landscape Across Murine Pregnancy Yan Li, Jessica Vazquez, Melina Chavarria, Aleksandar Stanic-Kostic

30 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program 5:15 p.m. - 5:30 p.m. In Vitro Model of Bacterial Colonization for the Study of the Effect of the Endometrial Microbiota on the Reproductive Function Inmaculada Moreno, Iolanda Garcia-Grau, Angela Silva, Felipe Vilella, Diana Valbuena, Daniel Ramon, Carlos Simon 5:30 p.m. - 5:45 p.m. Perivascular Expression of Vascular Adhesion Protein 1 (VAP-1) in the Endometrium Regulates Uterine Natural Killer (uNK) Cell Recruitment and Spiral Artery Remodeling in Pregnancy Seley Gharanei, Ruban P. Durairaj, Tianrong Jin, Kuo-Kang Liu, Christopher Weston, Marko Salmi, Pia Rantakari, Sirpa Jalkanen, Jan J. Brosens, Bee K. Tan 5:45 p.m. - 6:00 p.m. Mice Lacking Functional TRPV2 Show Intrauterine Growth Restriction Katrien De Clercq, Charlotte Van den Eynde, Silvia Pinto, Voets Thomas, Vriens Joris 6:15 p.m. - 7:45 p.m. Connection Corners BONNET CREEK PAVILLION, LOWER LEVEL TENTED AREA New, Early and Mid-Career Investigators are invited to come meet and connect with Senior Investigators about jobs, career advice or just some friendly banter. Drinks and light appetizers provided. Table #1, “Your First SRI Meeting” 16 Thursday, March • Sandy Davidge, PhD • Les Myatt, PhD FRCOG Table #2, “From Trainee to PI” • Charles Ducsay, PhD • Robert Taylor, MD, PhD Table #3, “From the Bench to the Bedside” • Donald Peebles, MA, MD, FRCOG • Sophie Petropoulos, PhD • Emre Seli, MD Table #4, “Finding a Good Mentor - Mentor in the Cloud” • Elizabeth Bonney, MD • Bo Rueda, PhD • Emily Su, MD Table #5, “Networking Tips” • John Challis, PhD FRCOG FRSC • Sascha Drewlo, PhD • Murray Mitchell, DPhil, DSc Table #6, “Negotiating: Getting What You Need to Succeed” • Marilyn Cipolla, PhD • Stephen Matthews, PhD Table #7, “Clinical Grantsmanship” • Ayman Al-Hendy, MD, PhD • Anna David, PhD • Alan DeCherney, MD

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Thursday, March 16, continued Table #8, “Basic Science Grantsmanship” • Terry Morgan, MD, PhD • Stacy Zamudio, PhD Table #9, “Publishing Tips and Tricks” • Emmet Hirsch, MD • Chandrakant Tayade, DVM, PhD • Hugh Taylor, MD Table #10, “Physician-Scientist: Is There Time to Sleep?” • Serdar Bulun, MD Table #11, “A Healthy Work-Life Balance” • Vikki Abrahams, PhD • Patricia Jimenez, MD Table #12, “Careers Outside of Academia” • Lisa Halvorson, MD • Diana Morgenstern, MD, FACP

Friday, March 17 7:00 a.m. - 6:30 p.m. Registration BONNET CREEK FOYER 7:15 a.m. - 8:00 a.m. SRI Business Meeting (Members Only) FLORIDIAN D-I Breakfast Provided

Friday, March 17 8:00 a.m. - 9:00 a.m. President’s Distinguished Lecture II FLORIDIAN D-I Eligible for 1.0 AMA PRA Category 1 Credits™/ 1.0 Category 1 College Cognate Credits Molecular Stethoscope in Pregnancy Stephen Quake, PhD Lee Otterson Professor in the School of Engineering and Professor of Bioengineering of Applied Physics, and, By Courtesy, of Physics Stanford University 9:15 a.m. - 10:45 a.m. Concurrent Oral Presentations II Developmental Programming I FLORIDIAN C Moderators: John Challis, PhD, FRCOG, FRSC Alina Maloyan, PhD 9:15 a.m. - 9:30 a.m. The Mitochondria-Targeted Antioxidant MitoQ Prevents the Programming of Cardiovascular Dysfunction by Developmental Hypoxia in Sheep K.J. Botting, K.L. Skeffington, Y. Niu, B.J. Allison, K.L. Brain, N. Itani, C. Beck, A. Logan, M.P. Murphy, D.A. Giussani

32 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Friday, March 17, continued 9:30 a.m. - 9:45 a.m. Apidonectin Supplementation During Late Pregnancy Normalises Offspring Cardiac Hypertrophic Gene Expression in a Mouse Model of Maternal Obesity Owen R. Vaughan, Frederick J. Rosario, Megan Gossling, Theresa Powell, Thomas Jansson 9:45 a.m. - 10:00 a.m. Chronic Fetal Hypoxaemia & Maternal Antioxidants: Identifying Mechanisms and Treatments to Improve Postnatal Lung Structure & Function in Growth Restricted Offspring E.V. McGillick, S. Orgeig, B.J. Allison, K.L. Brain, Y. Niu, N. Itani, K.L. Skeffington, C. Beck, K.J. Botting, D.A. Giussani, J.L. Morrison 10:00 a.m. - 10:15 a.m. Effects of Prenatal Hypoxia on Fetal Cardiomyocyte Proliferation Laura M. Reyes, Amin Shah, Anita Quon, Sandra T. Davidge 10:15 a.m. - 10:30 a.m. Maternal Obesity (MO) Compromises Term Fetal Offspring (F1) Heart Mitochondrial Bioenergetic Profile Qiurong Wang, Chaoqun Zhu, John F. Odhiambo, Guadalupe L. Rodriguez Gonzalez, Peter W. Nathanielsz, Stephen P. Ford, Jun Ren, Wei Guo 10:30 a.m.- 10:45 a.m. Fetal Growth Restriction Alters Chromatin Access in 1-Year-Old Rats with Metabolic Syndrome Erin K. Zinkhan, Baifeng Yu, Chris Callaway, Robert McKnight Fetus I BONNET CREEK X Moderators: Leslie Myatt, PhD, FRCOG Emily J. Su, MD

9:15 a.m. - 9:30 a.m. Oxygen and Glucose Supplementation Reduces 17 Friday, March Stress in Growth Restricted Sheep Fetuses Leticia Camacho, Melissa Davis, Nathan Steffens, Amy Kelly, Sean Limesand 9:30 a.m. - 9:45 a.m. Late-Onset Chronic Hypoxia Abolishes Adrenomedullary but Sensitises Adrenocortical Plasma Respones to Acute Stress in Fetal Sheep N. Itani, C.S. Shaw, B.J. Allison K.L. Brain, Y. Niu, C.C. Lees, D.A. Giussani 9:45 a.m. - 10:00 a.m. Effect of Maternal Antioxidant MitoQ Treatment in a Rat Model of Intrauterine Growth Restriction (IUGR) Esha Ganguly, Jude S. Morton, Christy L. Cooke, Sandra T. Davidge

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 33 Scientific Program

Friday, March 17, continued 10:00 a.m. - 10:15 a.m. Maternal Antioxidant Treatment Markedly Sensitises Antioxidant Gene Expression in Peri- Renal Fat of Fetal Offspring of Hypoxic Pregnancy A Martin, B.J. Allison, K.L. Brain, C. Ducsay, D. Myers, D.A. Giussani 10:15 a.m. - 10:30 a.m. Elevated Hepatic Gluconeogenesis by H19-Mediated Epigenetic Regulation Underlies Altered Metabolism in Offspring Prenatally Exposed to Metformin Jie Deng, Tingting Geng, Yunyuan Shen, Liyong Zhu, Ya Liu, Hugh S. Taylor, Michael Paidas, Yingqun Huang 10:30 a.m. - 10:45 a.m. In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanized Mouse Mode and Its Progress Can Be Monitored Using MRI Techniques Panicos Shangaris, Stavros Loukogeorgakis, Laurence Jackson, Wei Wang, Mike Blundell, Shanrun Liu, Sindhu Subramaniam, Simon Eaton, Mike Antoniou, Daniel Stuckey, Manfred Schmidt, Adrian Thrasher, Thomas Ryan, Paolo De Coppi, Anna David Endometriosis, Fibroids and Gynecology II FLORIDIAN B Moderators: Sarah L. Berga, MD Friday, March 17 Hiroshi Ishikawa, MD, PhD 9:15 a.m. - 9:30 a.m. Mechanisms of Dysregulated RANKL Gene Expression in Uterine Leiomyoma: Involvement of Epigenetic Modification and MED12 Gene Mutations Shimeng Liu, Ping Yin, Stacy A. Kujawa, Serdar E. Bulun 9:30 a.m. - 9:45 a.m. Ulipristal Treatment Highlights the Link of MED12 and Fibrosis Regulation in Leiomyomas Minnie Malik, Joy Britten, Lynnette Nieman, Matthew Wilkerson, Xijun Zhang, Jeris Cox, William Catherino 9:45 a.m. - 10:00 a.m. Feedback Regulation Between TGF-β3 and miR-29c in Leiomyoma Tasi-Der Chuang, Omid Khorram 10:00 a.m. - 10:15 a.m. Inflammatory and Immunological Processes are Strongly Dysregulated in Uterine Fibroids Compared to Normal Myometrium and Are Shown to Offer Novel as well as Effective Treatment Options for Uterine Fibroids Jörg Müller, Anette Sommer, Andrea Wagenfeld, Markus Koch, Thomas M. Zollner

34 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Friday, March 17, continued 10:15 a.m. - 10:30 a.m. Rank-Fc Inhibits Growth of Leiomyoma Cells and Decreases Tumor Growth In Vivo Deborah E. Ikhena, Shimeng Liu, Stacy Kujawa, Serdar E. Bulun, Ping Yin 10:30 a.m. - 10:45 a.m. Expression of Tumor Suppressor PCDH10 in Uterine Leiomyomas and Leiomyomasarcomas Joie Z. Guner, Gyoung E. Kim, Meaghan A. Delaney, Triparna Ghosh-Choudhury, Cecilia Valdes, William Gibbons, Matthew L. Anderson Parturition II BONNET CREEK XII Moderators: K. Joseph Hurt, MD, PhD Joy Vink, MD 9:15 a.m. - 9:30 a.m. Human Labour: A Joint Venture of PRA and Erα Lubna Nadeem, Hedy Romero, Oksana Shynlova, Sam Mesiano, Stephen Lye 9:30 a.m. - 9:45 a.m. Thrombin-Induced Decidual CSF2 Induces Abruption-Related Preterm Birth by Weakening Fetal Membranes Rachel Sinkey, Sefa Arlier, Robert Moore, Frederick Schatz, Nihan Smerci, Chinedu Nwabuobi, Kellie Larsen, Ozlem Guzeloglu-Kayisli, Deepak Kumar, John Moore, Umit Kayisli, Charles Lockwood 9:45 a.m. - 10:00 a.m. Uterine Preconditioning Regulates Gestational Length Judith Ingles, Jennifer Condon, Pancharatnam Jeyasuria 10:00 a.m. - 10:15 a.m. IL-1 Signaling is Critical for Neutrophil Recruitment and Activation in a Rhesus Macaque Model of Intrauterine Inflammation Pietro Presicce, Paranthaman Senthamaraikannan, Courtney Friday, March 17 Friday, March Jackson, Cesar M. Rueda, Lisa A. Miller, Claire A. Chougnet, Alan H. Jobe, Suhas G. Kallapur 10:15 a.m. - 10:30 a.m. Platelet Activating Factor (PAF) Induces Preterm Birth in Mice Through TLR4-Dependant Induction of Pro-Inflammatory Cytokines Hanan H. Wahid, Lachlan M. Moldenhauer, Kenner C. Rice, Mark R. Hutchison, Sarah A. Robertson 10:30 a.m. - 10:45 a.m. Oxidative Stress Induced p38MAPK Activation in Human Amnion Epithelial Cells are Independent of ASK1-Signalosome L. Richardson, C.L. Dixon, R. Menon

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 35 Scientific Program

Friday, March 17, continued Placenta I BONNET CREEK XI Moderators: Tania L. Gonzalez, PhD Loren P. Thompson, PhD 9:15 a.m. - 9:30 a.m. The Detection of Placental Oxygenation by Photoacoustic Imaging and Ultrasound Liliya M. Yamaleyeva, Yao Sun, Tiffaney Bledsoe, K. Bridget Brosnihan 9:30 a.m. - 9:45 a.m. The Human Placental Proteome Secreted into the Maternal and Fetal Circulations Trond M. Michelsen, Tore Henriksen, Theresa L. Powell, Thomas Jansson 9:45 a.m. - 10:00 a.m. The Use of Circulating MicroRNAs to Predict Placental Dysfunction in Women at Risk of Stillbirth Bernadette C. Baker, Sylvia Lui, Alexandar E.P. Heazell, Karen Forbes, Rebecca L. Jones 10:00 a.m. - 10:15 a.m. Insertion of Human Corticotrpin-Releasing Hormone and Retroviral Regulatory Element THE1B into the Mouse Genome Delays Timing Catlin E. Dunn-Fletcher, Lisa M. Muglia, Elizabeth L. Huffman, Louis J. Muglia 10:15 a.m. - 10:30 a.m. Oxygen-Dependent JMJD6 Regulation of Fibronectin Synthesis and Assembly in the Human Friday, March 17 Placenta Sruthi Alahari, Isabella Caniggia 10:30 a.m. - 10:45 a.m. A Distinct Signature of ATP-Binding Cassete Transporter Expression in the Preterm Human Placenta with Chorioamnionitis Guinever E. Imperio, Enrrico Bloise, Mohsen Javan, Phetcharawan Lye, Andrea Constantinof, Caroline Dunk, Fernando M. Reis, Stephen J. Lye, William Gibb, Tania M. Ortega-Carvalho, Stephen G. Matthews Reproductive Endocrinology and Infertility I FLORIDIAN A Moderators: Lisa Halvorson, MD Satu Kuokkanen, MD, PhD 9:15 a.m. - 9:30 a.m. Cross-Sex Testosterone Therapy is Not Sufficient for Bone Development in Female Mice: Implications for Treating Transgender Youth Laura G. Goetz, Ramanaiah Mamillapalli, Maureen J. Devlin, Masoumeh Majidi-Zolbin, Hugh S. Taylor

36 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Friday, March 17, continued 9:30 a.m. - 9:45 a.m. Elevated Androgen Levels Impair Connexin43 Function Leading to Decreased EDHF-Mediated Relaxation and Hypertension in Adult Female Rats Amar More, Jay Mishra, Sathish Kumar 9:45 a.m. - 10:00 a.m. Steroidogenic Factor 1 (Nr5a1) is Necessary for Sertoli Cell Differentiation Post Sex Determination Chandra S. Miryala, Prashanth Anamthathmakula, Jennifer Ondon, Revecca Moreci, Jeyasuria Pancharatnam 10:00 a.m. - 10:15 a.m. Effects of Oxytocin on Atrophic Rat Vagina Bernhard Lindenthal, Peter uhn, Ulrike Fuhrmann, Ildiko Terebesi, Ralf Lesche, Qiong Lin, Reinhard Nubbemeyer, Thomas M. Zollner, Christina Bartnitzek 10:15 a.m. - 10:30 a.m. Obesity Prevents Protective Down-Regulation of Mitogenic Insulin Receptor A in Uteri of Diet- Induced Obese Mice Clare Flannery, Caitlin Radford, Farrah Saleh, Gina Choe, Jung Dae Kim, Sabrina Diano, Hugh Taylor 10:30 a.m. - 10:45 a.m. Altered Early Luteal Phase miRNA 483-3p Expression in Women with PCOS Iris Eisenberg-Loebl, Debra Goldman-Wohl, Caryn Greenfield, Ronit Haimov-Kochman, Simcha Yagel, Tal Imbar 10:45 a.m. - 12:15 p.m. Poster Session II BONNET CREEK I-IX 12:30 p.m. - 2:00 p.m. Special Symposium II: Precision Medicine and Women’s Health FLORIDIAN D-I Moderator: Diana Bianchi, MD 12:30 p.m. - 1:00 p.m. Precision Medicine and Women’s Health Linda Guidice, MD, PhD, MSc 1:00 p.m. - 1:30 p.m. Fetal Precision Medicine Diana Bianchi, MD 17 Friday, March 1:30 p.m. - 2:00 p.m. Precision Medicine for Gynecologic Cancers Gordon Mills, MD 12:30 p.m. - 2:00 p.m. Pfizer-SRI President’s Presenter’s Award Lunch (Invitation Only) ORANGE

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 37 Scientific Program

Friday, March 17, continued 2:15 p.m. - 3:45 p.m. Concurrent Oral Presentations III Clinical Perinatology II BONNET CREEK X Moderators: Levent Mutlu, MD Marc Spaanderman, MD, PhD 2:15 p.m. - 2:30 p.m. Differential Increases in First Trimester Maternal Weight (MW) by Maternal Age Over the Past Decade in 2.6 Million Pregnancies: Opportunity to Target Teenagers for Obesity Prevention Shara M. Evans, David A. Krantz, Terrance W. Hallahan, Mark I. Evans 2:30 p.m. - 2:45 p.m. Apidonectin Prevents Obesity and Hepatic Steatosis in Mouse Offspring Born to Obese Dams Megan Gossling, Frederick Rosario, Stephanie Wesolowski, Thomas Jansson, Theresa Powell 2:45 p.m. - 3:00 p.m. A Randomized Controlled Trial of an M-Health Behavioural Lifestyle Intervention to Prevent Gestational Diabetes in Overweight and Obese Pregnancy: PEARS Maria A. Kennelly, Kate M. Ainscough, Elizabeth J. O’Sullivan, Karen L. Lindsay, Fionnuala M. McAuliffe 3:00 p.m. - 3:15 p.m. Mild Intraventricular Hemorrhage is Not Associated with Low Bayley Scores at Age 2 Friday, March 17 Emilie Vander Haar, Adina Goldberger, Cynthia Gyamfi- Bannerman 3:15 p.m. - 3:30 p.m. Adrenomedullin is a New Modulator of Lipolysis in Human Adipocytes Yuanlin Dong, Chandra Yallampalli 3:30 p.m. - 3:45 p.m. The Impact of Altered IL-1 Signaling on Metabolic Dysfunction During Pregnancy Jasmine Plows, Thashma Ganapathy, Phililp Baker, Mark Vickers, Joanna Stanley, Clare Reynolds Epidemiology, Population Health and Global Health - Focus on Zika BONNET CREEK XII Moderators: Irina Burd, MD, PhD Indira U. Mysorekar, PhD 2:15 p.m. - 2:30 p.m. Short Interpregnancy Interval After Pregnancy Loss is Associated with Decreased Risk of Subsequent Miscarriage in a Prospective Cohort Alexandra C. Sundermann, Katherine E. Hartmann, Sarah H. Jones, Eric S. Torstenson, Digna R. Velez Edwards

38 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Friday, March 17, continued 2:30 p.m. - 2:45 p.m. Evaluating the Clinical Burden of Preeclampsia (PEC) on a Tertiary Care Hospital in Harare, Zimbabwe Lydia L. Shook, Muchabayiwa F. Gidiri, Kara M. Rood, Irina A. Buhimschi 2:45 p.m. - 3:00 p.m. Zika Virus Infects Human Endometrial Stromal Cells Paola Panina-Bordignon, Isabel Pagani, Silvia Ghezzi, Adele Ulisse, Alicia Rubio, Elisabetta Garavaglia, Giuseppe Ippolito, Guido Poli, Elisa Vicenzi 3:00 p.m. - 3:15 p.m. Zika Virus Infection Damages the Testes in Mice Jacques Halabi, Prabagaran Esakky, Suzanne Scheaffer, Andrea Drury, Michael S. Diamond, Kelle H. Moley 3:15 p.m. - 3:30 p.m. Hypermesis Gravidarum: Risk of Recurrence in Subsequent Pregnancies Michael J. Fassett, Morgan R. Peltier, Darios Getahun 3:30 p.m. - 3:45 p.m. Zika Infection in Pregnant Rhesus Macaques Results in Placental Injury and Altered Brain Development Independent of Microcephaly Peta L. Grigsby, Victoria H. Roberts, Alec J. Hirsch, Matthias C. Schabel, Chris D. Kroenke, Jamie O. Lo, Xiaojie Wang, Zheng Liu, Jessica Smith, Nicole Haese, Meredith Kelleher, Rebecca Broeckel, Craig N. Kreklywich, Christopher J. Parkins, Patricia Smith, Victor DeFillppis, William Messer, Jay A. Nelson, Jon D. Hennebold, Marjorie Grafe, Lois Colgin, Anne Lewis, Rhonda MacAllister, Terry K. Morgan, Antonio E. Frias, Daniel N. Streblow Gynecologic Oncology FLORIDIAN B Moderators: Matthew L. Anderson, MD, PhD Stefan M. Gysler, MD, MHS 2:15 p.m. - 2:30 p.m. The Impact of the Cholesterol Metabolite 17 Friday, March 27-Hydroxycholesterol on Endometrial Proliferation Douglas A. Gibson, Frances Collins, Arantza Esnal, Alistair R.W. Williams, Philippa T.K. Saunders 2:30 p.m. - 2:45 p.m. SYD985 Shows Antitumor Activity in Uterine and Ovarian Cardinosarcoma with HER2/Neu Expression Gulden Menderes, Elena Bonazzoli, Jonathan D. Black, Stefania Bellone, Francesca Pattinelli, Alice Masserdetti, Luca Zammataro, Gary Altwerger, Natalia Buza, Pei Hui, Serena Wong, Elena Ratner, Babak Litkouhi, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Peter Goedings, Patrick Beusker, Miranda van der Lee Marco, Timmers Wim Dokter, Alessandro D. Santin

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 39 Scientific Program

Friday, March 17, continued 2:45 p.m. - 3:00 p.m. Serum MicroRNA Sequencing for Early Diagnosis of Invasive Ovarian Cancer Kevin M. Elias, Wojciech F. Fendler, Konrad Stawiski, Allison Vitonis, Ross S. Berkowitz, Daniel W. Cramer, Dipanjan Chowdhury 3:00 p.m. - 3:15 p.m. Exosomal Content in the Plasma of Patients with Ovarian Cancer Reflect Tumor State and Induce the Epithelial to Mesenchymal Transition in Target Cells Shayna Sharma, Kathin Scholz-Romero, Richard Kline, Katrina Wade, Jacob Estes, Carlos Palma, Dominic Guanzon, Andrew Lai, John Hooper, Gregory E. Rice, Carlos Salomon 3:15 p.m. - 3:30 p.m. Targeting Integrin αV/β1 Receptor Manifests Intriguing Anti-Tumor Effects in Sensitive and Chemoresistant Ovarian Cancer Cells: Potential Therapeutic Target Ghassan M. Saed, Nicole M. Fletcher, Ira Memaj, Mohammed G. Saed, Michael P. Diamond, Robert T. Morris 3:30 p.m. - 3:45 p.m. FDG-PET/CT Kinetic Modeling Provides Detailed Information of Glucose Metabolism in Ovarian Cancer Xiaohua Yang, Kuan-Hao Su, Jung-Wen Kuo, Mustafa Tunc, Stefanie Avril, Analisa DiFeo, Raymond F Muzic Jr, Norbert Friday, March 17 Avril Endometriosis, Fibroids and Gynecology III FLORIDIAN C Moderators: Micah J. Hill, DO Joop Laven, MD, PhD 2:15 p.m. - 2:30 p.m. ATG4D Silencing Abrogates Autophagy and Induces a Fibroid-Like Transformation in Normal Human Myometrium Cells Abdeljabar El Andaloussi, Nahed Ismail, Ayman Al-Hendy 2:30 p.m. - 2:45 p.m. Can Preimplantation Genetic Screening (PGS) Be Applied to Previously Untested Cryopreserved Blastocysts? Jessica Rubin, Alfred Wun, Cecilia Valdes, Randall Dunn 2:45 p.m. - 3:00 p.m. The Impact of Excisional Treatment for Cervical Intraepithelial Neoplasia on the Vaginal Microbiota Anita Mitra, David MacIntyre, Jonathan Lai, Yun Lee, Ann Smith, Julian Marchesi, Deirdre Lyons, Phillip Bennett, Maria Kyrgiou

40 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Friday, March 17, continued 3:00 p.m. - 3:15 p.m. Progestin-Only Contraceptives Induce Decidualization by Enhancing ZBTB16 Expression: Implications for Abnormal Uterine Bleeding Sefa Arlier, Ozlem Guzeloglu-Kayisli, Nihan Semerci, Kellie Larsen, Unit Kayisli, Frederick Schatz, Charles Lockwood 3:15 p.m. - 3:30 p.m. A Calcium Channel Blocker Used to Treat Hypertension Alters Contractility of the Uterosacral Ligament: Implications for Pelvic Organ Prolapse Marsha K. Guess, Joshua Johnson, Ritsuko Iwanaga, Kathleen A. Connell 3:30 p.m. - 3:45 p.m. LGR5 is Expressed by Human Endometrial Epithelial Cells and Regulated by Progesterone Nicola Tempest, Dharani Hapangama Preeclampsia II BONNET CREEK XI Moderators: Chahinda Ghossein-Doha, MD Carlos Simon, MD, PhD 2:15 p.m. - 2:30 p.m. VEGF Simulates Macrophage Recruitment and M2-Polarization in the Decidua: Potential Relevance to the Pathogenesis of Preeclampsia Karen C. Wheeler, Manoj Jena, Bhola S. Pradhan, Bo Pei, Neha Nayak, Subhendu Das, Sabita Dhal, Kang Chen, Nihar R. Nayak 2:30 p.m. - 2:45 p.m. Syncytiotrophoblast Extracellular Vesicles Alter Angiotensin-II Induced Vasoconstriction in Mouse Uterine Arteries Floor Spaans, Jude S. Morton, Dionne S. Tannetta, Ian L. Sargent, Sandra T. Davidge 2:45 p.m. - 3:00 p.m. Severe Preeclampsia is Associated with Resistance to Decidualization Tamara Garrido-Gomez, Francisco Dominguez, Alicia 17 Friday, March Quinonero, Patricia Diaz-Gimeno, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Pablo Padilla, Olga Genbacev, Alfredo Perales, Susan J. Fisher, Carlos Simon 3:00 p.m. - 3:15 p.m. Placental Extracellular Vesicles Can Sequester VEGF to Induce Endothelial Cell Activation: Relevance for Preeclampsia Mancy Tong, Qi Chen, Jo L. James, Peter R. Stone, Larry W. Chamley 3:15 p.m. - 3:30 p.m. Evidence for Partial Overlap of Molecular Etiology Between Preeclampsia and Decidualization Disorders Maria B. Rabaglino, Emiel D. Post Uiterweer, Kirk P. Conrad

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 41 Scientific Program

Friday, March 17, continued 3:30 p.m. - 3:45 p.m. High Resoluation Flow Cytometry Reveals Abnormal Distribution of Placental Extracellular Vesicles in Murine Placental Insufficiency Model Nicole Marek, Mayu Morita, Pam Canaday, Terry K. Morgan Reproductive Biology II FLORIDIAN A Moderators: Linda C. Giudice, MD, PhD, MSc Terrence D. Lewis, MD, PhD 2:15 p.m. - 2:30 p.m. Granulocyte-Colony Stimulating Factor Reverses Detrimental Effects of High-Fat Diet on Ovarian Reserve Delaney C. Swindle, Alex J. Polotsky, Malgorzata E. Skaznik- Wikiel 2:30 p.m. - 2:45 p.m. High-Fat Diet and Aging Affect Ovarian RAGE Gene Expression Erkan Buyuk, Maureen Charron, Kimberley Thornton, Obehi Asemota, Zaher Merhi 2:45 p.m. - 3:00 p.m. AKAP13-Deficient Oocytes Show Signs of Precocious Exit from Prophase I Arrest Carter M. Owen, Ophelia Yin, Sinnie Ng, Pola Olczak, Janice P. Evans, James H. Segars 3:00 p.m. - 3:15 p.m. Maternally Expressed NLRP2 Links the Subcortical Maternal Complex (SCMC) to Fertility, Friday, March 17 Embryogenesis and Epigenetic Reprogramming Sangeetha Mahadevan, Varsha Sathappan, Budi Utama, Isabel Lorenzo, Khalied Kaskar, Ignatia Van den Veyver 3:15 p.m. - 3:30 p.m. DMPS (Dimercapto-1-Propanesulfonic Acid), a Heavy Metal Chelator, Induces Oocyte Deterioration Sarah R. Aldhaheri, Roohi Jeelani, Mili Thakur, Marisa Hildebrandt, Farnoosh Qadri, Husam M. Abu-Soud 3:30 p.m. - 3:45 p.m. Med12 is Critical in Reproductive Tract Development Xinye Wang, Priya Mittal, Aleksandar Rajkovic 4:00 p.m. - 6:00 p.m. Mini Symposia II Mining Big Data to Reveal Biomarkers and Pathophysiology of Preterm Birth BONNET CREEK XII Eligible for 2.0 AMA PRA Category 1 Credits™/ 2.0 Category 1 College Cognate Credits Moderator: Sam Mesiano, PhD 4:00 p.m. - 4:30 p.m. Maternal Peripheral Blood Leukocytes as Biomarkers of Preterm Birth Oksana Shynlova, PhD 4:30 p.m. - 5:00 p.m. Multi-Omic Data Integration and Interrogation to Discover Network Signatures of Preterm Birth Doug Brubaker, PhD 42 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Friday, March 17, continued 5:00 p.m. - 5:30 p.m. In Richness and In Health: The Role of Vaginal Microbiota in Pregnancy David MacIntyre, PhD 5:30 p.m. - 6:00 p.m. The Use of Next-Generation Sequencing and Family Studies to Uncover Rare Genetic Variants Associated with Preterm Birth Wei Ang, MSc Molecular Biology of Implantation and Recurrent Pregnancy Loss FLORIDIAN A Eligible for 2.0 AMA PRA Category 1 Credits™/2.0 Category 1 College Cognate Credits Moderator: Vikki M. Abrahams, PhD 4:00 p.m. - 4:30 p.m. Molecular Regulation of Endometrial Plasticity in Implantation and Recurrent Pregnancy Loss Jan J. Brosens, MD, PhD 4:30 p.m. - 5:00 p.m. Role of Endogenous Retroviruses in the Establishment and Maintenance of Pregnancy Neal S. Rote, PhD 5:00 p.m. - 5:30 p.m. MicroRNA Regulation of Immunotolerance in Early Pregnancy Sarah A. Robertson, PhD 5:30 p.m. - 6:00 p.m. Novel Mechanisms of Placental Inflammation in Obstetric Antiphosolipid Syndrome Vikki M. Abrahams, PhD Immune Cell Contributions to Endometrial and Cervical Health and Disease BONNET CREEK X Eligible for 2.0 AMA PRA Category 1 Credits™/2.0 Category 1 College Cognate Credits Moderator: Chandrakant Tayade, DVM, PhD 4:00 p.m. - 4:30 p.m. Modulation of Inflammatory Responses in the Female Reproductive Tract Charles Wira, PhD 17 Friday, March 4:30 p.m. - 5:00 p.m. Immune Basis of Infertility Bruce Lessey, MD, PhD 5:00 p.m. - 5:30 p.m. Tissue Resident Uterine Immune Cells Dorothy K. Sojka, PhD 5:30 p.m. - 6:00 p.m. Immune Cell Contributions to Initiation of Endometriosis Chandrakant Tayade, DVM, PhD Gamete Biology and Gene Editing FLORIDIAN B Eligible for 2.0 AMA PRA Category 1 Credits™/2.0 Category 1 College Cognate Credits Moderator: Kyle Orwig, PhD

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 43 Scientific Program

Friday, March 17, continued 4:00 p.m. - 4:30 p.m. Mitochondrial Replacement Therapy David L. Keefe, MD 4:30 p.m. - 5:00 p.m. iPSC-Mediated Germline Gene Therapy Renee A. Reijo Pera, PhD 5:00 p.m. - 5:30 p.m. Mitochondrial Diseases and Mitochondrial Replacement Therapy Michio Hirano, MD 5:30 p.m. - 6:00 p.m. Germline Gene Therapy with Spermatogonial Stem Cells Kyle Orwig, PhD Frontiers in Diagnosis, Treatment and Prevention of CMV and Zika in Pregnancy BONNET CREEK XI Eligible for 2.0 AMA PRA Category 1 Credits™/2.0 Category 1 College Cognate Credits Moderator: Simcha Yagel, MD 4:00 p.m. - 4:30 p.m. Ex-Vivo Model of CMV Transmission Simcha Yagel, MD 4:30 p.m. - 5:00 p.m. Placental Trophoblasts and Viral Resistance in Recipient Cells Yoel Sadovsky, MD 5:00 p.m. - 5:30 p.m. Patterns of CMV and ZIKV Infection in the Uterine- Placenta Interface and Routes of Vertical

Friday, March 17 Transmission Lenore Pereira, PhD 5:30 p.m. - 6:00 p.m. Vaccine Development to Control CMV Disease: Immune Manipulation by the Virus Edward Mocarski, PhD Linking Early Life Exposures to Later Pathology FLORIDIAN C Eligible for 2.0 AMA PRA Category 1 Credits™/2.0 Category 1 College Cognate Credits Moderator: Dino A. Giussani, PhD, ScD, FRCOG 4:00 p.m. - 4:30 p.m. Heart Disease Link to Fetal Hypoxia: An Intergenerational Perspective Dino A. Giussani, PhD, ScD, FRCOG 4:30 p.m. - 5:00 p.m. Maternal Obesity and Offspring Cardiometabolic Disease: Unravelling the Underlying Mechanisms Rebecca M. Reynolds, PhD, FRCP, FRCPE 5:00 p.m. - 5:30 p.m. The Obesity Epidemic: Could it be an Oocyte Issue? Kelle H. Moley, MD 5:30 p.m. - 6:00 p.m. Epigenetic Impact of Prenatal Exposure to Adversity Frances A. Champagne, PhD 6:15 p.m. - 7:45 p.m. President’s Address, Awards, and Wine and Cheese Reception FLORIDIAN D-1

44 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program Saturday, March 18 7:00 a.m. - 1:00 p.m. Registration BONNET CREEK FOYER 8:00 a.m. - 9:00 a.m. President’s Distinguished Lecture III FLORIDIAN D-I Eligible for 1.0 AMA PRA Category 1 Credits™/1.0 Category 1 College Cognate Credits Maternal-Fetal Conflict and Cooperation in Human Pregnancy David Haig, PhD George Putnam Professor of Organismic and Evolutionary Biology Harvard University 9:00 a.m. - 10:30 a.m. Poster Session III BONNET CREEK I-IX 10:30 a.m. - 12:00 p.m. Concurrent Oral Presentations IV Developmental Programming II FLORIDIAN B Moderators: Sophie Petropoulos, PhD Jorge P. Figueroa, MD, PhD 10:30 a.m. - 10:45 a.m. Predictive Modelling of Stress-Related Behavior Through Gene Expression Following Prenatal Glucocorticoid Exposure Andrea Constantinof, Vasilis Moisiadis, Stephen Matthews 10:45 a.m. - 11:00 a.m. Treatment with Prenatal Glucocorticoids in Baboons Predisposes Male Offspring (F1) to Obesity in Adulthood Hilary F. Huber, Anderson H. Kuo, Cun Li, Susan L. Jenkins, Peter W. Nathanielsz 11:00 a.m. - 11:15 a.m. Maternal Obesity is Associated with Decreased Dopamine Signaling in Juvenile Offspring: A Transgenerational Obesity Cycle Larissa H. Mattei, Chang Xue, Rachel Zeuner, Emmanuel N. Pothos, Angrea G. Edlow 11:15 a.m. - 11:30 a.m. Accelerated Ovarian Ageing Induced by Chronic Fetal Hypoxia C.E. Aiken, J.L. Tarry-Adkins, A.M. Spiroski, A.M. Nuzzo, S.E. Ozanne, D.A. Giussani 11:30 a.m. - 11:45 a.m. In Utero Bisphenol-A Exposure Leads to Altered Uterine Stromal Cell Migration and Adenomyosis Myles H. Alderman III, Demetra Hufnagel, Hugh S. Taylor 11:45 a.m. - 12:00 p.m. Nutrient Sensor-Epigenome Regulation of Apidogenesis Programs Obesity in Offspring of Obese Mothers Mina Desai, Guang Han, Kavita Narwani, Elaheh Mossayebi,

Marie H. Beall, Michael G. Ross 18 March Saturday,

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 45 Scientific Program

Saturday, March 18, continued Fetus II BONNET CREEK X Moderators: Peta L. Grigsby, PhD Dean A. Myers, PhD 10:30 a.m. - 10:45 a.m. Cardiac Assessment by 4D Echocardiography of Fetal Guinea Pigs Shifa Turan, Graham W. Aberdeen, Loren P. Thompson 10:45 a.m. - 11:00 a.m. Neuronal Exosome Synaptopodin: An Early Predictor of Therapeutic Response to Controlled Hypothermia Laura Goetzl, Diana Martirosyan, Nune Darbinian, Nana Merabova, Keri Fugarolas, Ogechukwu Menkiti 11:00 a.m. - 11:15 a.m. Volumetric and Vascular MRI Placental Changes with Exposure to Intrauterine Inflammation: Biomarker of Fetal Brain Injury Jun Lei, Dan Wu, Solange Eloundou, Wael Alshehri, Jiangyang Zhang, Irina Burd 11:15 a.m. - 11:30 a.m. Chronic Hypoxia Alters Fetal Cerebrovascular Responses to Endothelin-1 Jinjutha Silpanisong, Dahlim Kim, James M. Williams, Olayemi O. Adeoye, William J. Pearce 11:30 a.m. - 11:45 a.m. Role of Uric Acid and GLUT9 in Pregnancy on Neonatal Development Benjamin P. Lüscher, Daniel V. Surbek, Camilla Marini, Marc U. Baumann 11:45 a.m. - 12:00 p.m. Cardiac miRNA Expression in the Fetus and Six Month Old Sheep in Response to Myocardial Infarction Mitchell Lock, Jia Yin Soo, Jack Darby, Doug Brooks, Enzo Porrello, Ross Tellam, Janna Morrison Parturition III BONNET CREEK XII Moderators: Jennifer Herington, PhD Mala Mahendroo, PhD

Saturday, March 18 10:30 a.m. - 10:45 a.m. Effect of Amnion Derived Exosomes on Feto- Maternal Gestational Cells: Novel Signalers in the Labor Cascade? Emily E. Hadley, Samantha Sheller, Rheanna Urrabaz-Garza, Talar Kechichian, George Saade, Sam Mesiano, Robert Taylor, Ramkumar Menon 10:45 a.m. - 11:00 a.m. Collagen Type 1 Gels Augment Healing of Ruptured Amnion in Mouse PROM Haruta Mogami, Annvarapu H. Kishore, R. Ann Word

46 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Saturday, March 18, continued 11:00a.m. - 11:15 a.m. Mechanisms Underlying the Effects of Retosiban/ GSK221149A on the Response to Mechanical Stretch in Human Myometrial Explants Irving L.M.H. Aye, Alex Moraitis, D. Stephen Charnock-Jones, Gordon C.S. Smith 11:15 a.m. - 11:30 a.m. Characterization of Peptides Against Neuromedin U Receptor 2 in Preterm Labor Amarilys Boudreault, Christiane Quiniou, Xin Hou, Mathieu Nadeau-Vallée, Sylvain Chemtob 11:30 a.m. - 11:45 a.m. Adiponectin Receptor Activation Mediates Myometrial Tocolysis: A Mechanism for Obesity Related Preterm Birth Vibhuti Vyas, Nathan Anderson, Rachael Bok, Theresa Powell, Thomas Jansson, Kenneth J. Hurt 11:45 a.m. - 12:00 p.m. Functional Pharmacology Coupled with Metabolomics Reveals Novel Pathways of Chlorophyll Compounds on Myometrial Activity Enitome E. Bafor, Edward G. Rowan, RuAngelie Edrada-Ebel Placenta II BONNET CREEK XI Moderators: Vicki L. Clifton, PhD Susanne Lager, PhD 10:30 a.m. - 10:45 a.m. Inhibition of the Auto-Inflammation Suppressor Protein ISG15 Triggers Preeclampsia by Blocking Trophoblast Migration and Invasion Nihan Semerci, Ozlem Guzeloglu-Kayisli, Sefa Arlier, Kellie Larsen, Chinedu Nwabuobi, Frederick Schatz, Antony Obido, Charles Lockwood, Umit Kayisli 10:45 a.m. - 11:00 a.m. Rosiglitazone Reduces Endotoxin Mediated Effects on Inflammation and Trophoblast Differentiation in First Trimester Human Placenta Leena T. Kadam, Brian Kilburn, Aalem Singh, Hamid Reza Kohan-Ghadr, Sascha T. Drewlo 11:00 a.m. - 11:15 a.m. SDF2 is a Novel Component of ER Stress-Induced Apoptosis Pathway in Trophoblast Cells via PERK- eIF2 Alpha-ATF4 Branch Aline R. Lorenzon-Ojea, Clarissa R. Rocha, Estela Bevilacqua 11:15 a.m. - 11:30 a.m. Human Placental Endothelial Cells are Capable of Recovering from Failed Angiogenesis Secondary to Impaired Wnt Signaling Toluwalope O. Junaid, Paul Brownbill, Edward D. Johnstone, John D. Aplin Saturday, March 18 March Saturday,

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 47 Scientific Program

Saturday, March 18, continued 11:30 a.m. - 11:45 a.m. mTOR Inhibition Down-Regulates Mitochondrial Function in Primary Human Trophoblast Cells and is Associated with Decreased Expression of Electron Transport Chain Complexes in IUGR Placentas F.J. Rosario, M.B. Gupta, L. Cox, T.L. Powell, T. Jansson 11:45 a.m. - 12:00 p.m. Sexual Dimorphism in the Regulation of Placental Metabolism and Fetal Growth by miR-210 Yu Wang, Matthew S. Bucher, Bailey L. Simon, Alina Maloyan, Leslie Myatt Reproductive Endocrinology and Infertility II FLORIDIAN A Moderators: Alan DeCherney, MD Reshef Tal, MD, PhD 10:30 a.m. - 10:45 a.m. Disruption of Mitochondrial Proteostasis Results in Impaired Mitochondrial Dynamics and Female Infertility Tianren Wang, Tim Sanchez, Daniel Neddleman, Denny Sakkas, Tamas Horvath, Emre Seli 10:45 a.m. - 11:00 a.m. Independent Serum Markers of Corpora Lutea Function After GnRH Agonist Trigger and Low Dose hCG in IVF Leah A. Kaye, Erica Anspach Will, Evelyn I. Neuber, John C. Nulsen, Claudio A. Benadiva, Lawrence Engmann 11:00 a.m. - 11:15 a.m. Creating a Hormonally Active 3-Dimensional Ovarian Follicle via a Microfluidic System Mae W. Healy, Shelley N. Dolitsky, Meera Raghavan, Alex Tillman, Maria Villancio-Wolter, Nicole Y. Morgan, Alan H. DeCherney, Erin F. Wolff, Solji Park 11:15 a.m. - 11:30 a.m. Discovery-Based Proteomic Profiling of Tubal Fluid in Hydrosalpinx Reveals Candidate Biomarkers Morgan E. Lindsay, Elizabeth H. Yohannes, Avedis A. Kazanjian, Ryan J. Heitmann, Richard O. Burney 11:30 a.m. - 11:45 a.m. Oocyte/Embryo Utilization Rates and Disposition

Saturday, March 18 Decisions in Fertility Preservation Patients Molly B. Moravek, Rafael Confino, Angela K. Lawson, Kristin N. Smith, Susan C. Klock, Mary Ellen Pavone 11:45 a.m. - 12:00 p.m. Utility of PGS to Determine the Need for Repeat Embryo Cryopreservation Cycles and Improve Fertility Preservation Success in Cancer Patients Ozgur Kan, Kutluk Oktay

48 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Scientific Program

Saturday, March 18, continued Stem Cells FLORIDIAN C Moderators: Panicos Shangaris, MD, BAO, MSc Hugh S. Taylor, MD 10:30 a.m. - 10:45 a.m. Cytoskeletal Tension and YAP Regulation Modulate Mechanosensation in Oogonial Stem Cells Julie A. MacDonald, Dori C. Woods, Jonathan L. Tilly 10:45 a.m. - 11:00 a.m. Identification of Novel Epigenetic Reprogrammed Genes in Myometrial Stem Cells Developmentally Exposed to Endocrine Disrupting Chemicals Qiwei Yang, Lindsey S. Trevino, Aymara Mas, Michael P. Diamond, Cheryl Lyn Walker, Ayman Al-Hendy 11:00 a.m. - 11:15 a.m. Maternal Mesenchymal Stem Cell Administration Alleviates Intrauterine Inflammation-Induced Perinatal Brain Injury Through CD8* T Cell Suppression in Placenta Li Xie, Honxi Zhao, Jun Lei, Lu Zhong, Hattan Arif, Michael McLane, Irina Burd 11:15 a.m. - 11:30 a.m. Trophoblast Spheroid Model Derived from hiPSCs to Study Trophoblast Functions Under Pathological- Like Conditions Mehboob Ali, Mark Hester, Lisa Zhao, Irian A. Buhimschi 11:30 a.m. - 11:45 a.m. High Throughput Screen (HTS) Using Viable Fluorescent ESC Reporters of Stressed-Forced Differentiation of the First Lineage Erica D. Louden, Elizabeth E. Puscheck, Quanwen Li, Kang Chen, Daniel A. Rappolee 11:45 a.m. - 12:00 p.m. Endothelial Progenitor Cells Contribute to Vasculogenesis of the Pregnant Mouse Uterus Reshef Tal, Dong Dirong, Shafiq Shaikh, Ramanaiah, Maimillapalli, Hugh S. Taylor Saturday, March 18 March Saturday,

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 49 Scientific Program 12:15 p.m. - 1:45 p.m. Hot Topics & Awards Ceremony FLORIDIAN D-I Lunch Included Moderators: Emre Seli, MD Marilyn Cipolla, PhD 12:15 p.m. – 12:30 p.m. Vertical Zika Virus Transmission in Pregnant Rhesus Macaques T. Golos, S. Nguyen, K. Antony, D. Dudley, S. Kohn, H. Simmons, B. Wolfe, S. Salamat, L. Teixeira, G. Wiepz, T. , M. Aliota, A. Weiler, G. Barry, M. Mohns, M. Brietbach, L. Stewart, M. Rasheed, C. Newman, O. Wieben, P. Turski, K. Johnson, J. Hayes, N. Schultz-Darken, S. Permar, E. Mohr, S. Capuano, A. Tarantal, J. Osorio, S. O’Connor, T. Friedrich, D. O’Connor 12:30 p.m. – 12:45 p.m. Infusion Of Human Bone Marrow-Derived Stem Cells Improved Ovarian Function In Chemotherapy- Damaged Ovaries In Mice Sonia Herraiz, Anna Buigues, Mónica Romeu, César Díaz- García, Aaron J. Hsueh Antonio Pellicer 12:45 p.m. – 1:00 p.m. Development of a Mid-Pregnancy Precision-Focused Test to Predict Preterm Birth Laura L Jelliffe-Pawlowski, Larry Rand, Rebecca J Baer, Bruce Bedell, Scott P. Oltman, Mary E. Norton, Gary M. Shaw, David K. Stevenson, Kelli K. Ryckman 1:00 p.m. – 1:15 p.m. Surfactant Protein A (SP-A) Prevents Delivery due to Intrauterine Infection with Live E. coli Even When Administered in a Delayed and Systemic Fashion Emmet Hirsch, Varkha Agrawal, Sana Hira, Mukesh K Jaiswal, Kenneth D. Beaman 2:00 p.m. - 4:00 p.m. SRI Council Meeting MANATEE Saturday, March 18

50 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

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52 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

(moved to S-036)

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 53 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

54 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

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56 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

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58 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

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60 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 61 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

62 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

ABSTRACT WITHDRAWN

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 63 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

64 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 65 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

66 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

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68 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 69 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

70 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom

(moved to Poster Guide S-190)

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 71 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

ABSTRACT WITHDRAWN

72 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

(moved to F-013) ABSTRACT WITHDRAWN

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 73 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

74 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

(moved to F-013)

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 75 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

76 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom

(moved to T-213) Poster Guide

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 77 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

78 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

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80 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

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82 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 83 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

84 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

ABSTRACT WITHDRAWN

ABSTRACT WITHDRAWN

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 85 Posters will be displayed Thursday, Friday and Saturday Poster Guide in the Bonnet Creek I - IX Ballroom Poster Guide

86 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Thank You to Our 2017 Poster Judges

Thank You to Our 2017 Poster Judges! Kristina Adams Waldorf, MD Men-Jean Lee, MD Terrence Allen, MBBS, FRCA Ronald R. Magness, PhD Matthew L. Anderson, MD, PhD Keiichi Matsubara, MD, PhD Dilly Anumba, MD, FRCOG, LLM Thomas F. McElrath, MD, PhD Samir N. Babayev, MD Elizabeth McGee, MD Gordon W. Bates, MD Ramkumar Menon, PhD Kelly Bennett, MD,FRCSC, MSc Sribalasubashin Muralimanoharan, PhD Phillip Bennett, MD, PhD Levent Mutlu, MD Lia Bernardi, MD Genevieve Neal-Perry, MD, PhD Irina Burd, MD, PhD Jane Norman, MD Byron C. Calhoun, MD Ijeoma Okeigwe, MD, MPH Linda Chambliss, MD, MPH George Osol, PhD Niraj R. Chavan, MD, MPH Yutaka Osuga, MD, PhD Dongbao Chen, PhD Jeyasuria Pancharatnam, PhD Marilyn Cipolla, PhD Samuel Parry, MD Jennifer Condon, PhD Mary Ellen Pavone, MD, MS Hilary Critchley, MD Margareta D. Pisarska, MD Anna L. David, PhD Emiel Post Uiterweer, MD, PhD Francesco DeMayo, PhD Robert Powers, PhD Evdokia Dimitriadis, PhD Karen Racicot, PhD Michael Fassett, MD Nilufer Rahmioglu, PhD Enrico Ferrazzi, MD Jared Robins, MD Hilary S. Gammill, MD Ghassan Saed, PhD Haijun Gao, PhD Joaquin Santolaya-Forgas, MD, PhD Michael Gravett, MD Laura C. Schulz, PhD Lisa Halvorson, MD Danny Schust, MD Natalie Josephine Hannan, PhD James Segars, MD Oskari Heikinheimo, MD, PhD Emre Seli, MD Denise Hemmings, PhD Panicos Shangaris, MD, BAO, MSc Jennifer Herington, PhD Oksana Shynlova, PhD Megan G. Hill, MBBS Robert J. Sokol, MD Iffath Hoskins, MD Jessica B. Spencer, MD, Msc Gloria Huang, MD Bethany Stetson, MD Arundhathi Jeyabalan, MD Emily J. Su, MD Mark Johnson, PhD Daniel V. Surbek, MD, Prof Amanda N. Kallen, MD Mancy Tong, PhD Candidate Jeffrey Keelan, PhD Rachel M. Tribe, PhD Matt Kemp, PhD Ganesa Wegienka, PhD Asma Khalil, MDres, MRCOG, MSc(epi) Hung Winn, MD, JD, MBA Seung-Yup Ku, MD, PhD Lynn M. Yee, MD, MPH Shathiyah Kulandavelu, PhD Liang Yu, PhD Sathish Kumar, DVM, PhD Stacy Zamudio, PhD Uwe Lang, MD, PhD Erin Zinkhan, MD Louise C. Laurent, MD, PhD Krina Zondervan, MSc, DPhil

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 87 SRI Grants Program SRI is pleased to announce the continuation of the SRI Grants Program and the establishment of the International Training Grant Program. The Grants Program provides two $50,000 awards to current SRI members each year. The objective of the grants is to support the research of promising scientists who are beginning their independent research careers. The scope of the science can be basic, translational or clinical. It must be related to women’s health. The International Training Grant provides three trainees, at $5,000 each, an opportunity to obtain research experience in an Institution outside of their home country for 4-8 weeks. Dr. Yoel Sadovsky, SRI President, the SRI Council and Grants Committee thank the following SRI members and distinguished guest scientists who served as expert reviewers for the 2017 SRI Grant applications.

Larry Chamley, PhD, FSRB, University of Auckland, Alison Holloway, PhD, McMaster University, Canada New Zealand S. Joseph Huang, MD, PhD, University of South Florida, Judy Chang, MD, MPH, University of Pittsburgh, USA USA Dong Bao Chen, PhD, University of California, Irvine, Carl Hubel, PhD Magee-Womens Research Institute, USA Pittsburgh, USA Marilyn Cipolla, PhD, University of Vermont, USA Helen Kay, MD, Advocate Medical Group, USA Jennifer Condon, PhD, Wayne State University, Louise Laurent, MD, PhD, UCSD School of Medicine, Detroit, USA USA Kathleen Connell, MD, University of Colorado, Denver, Stephen Lye, PhD, Lunenfeld-Tanenbaum Research USA Institute, Canada Christy-Lynn Cooke, MD, PhD, University of Alberta, Daniel MacPhee, PhD, University of Saskatchewan, Canada Canada Mina Desai, PhD, David Geffen SOM at Harbor-UCLA, Alina Maloyan, PhD, Oregon Health and Science USA University, USA Sascha Drewlo, PhD, Wayne State University, USA John Moore, MD, Case Western-MetroHealth, USA Enrico Ferrazzi, MD, Buzzi Children’s Hospital University Theresa Powell, PhD, University of Colorado, Milan, Italy Denver, USA Martin Frasch, MD, PhD, University of Washington, USA Robert Powers, PhD, Magee Womens Research Antonio Frias, MD, Oregon Health & Science University, Institute, Pittsburgh USA USA Bo Rueda, PhD, MGH, Harvard Medical School, USA Paul Fowler, PhD, University of Aberdeen, UK Paolo Rinaudo, MD, PhD, University of California, San Dino Giussani, PhD, University of Cambridge, UK Francisco, USA Jane Girling, PhD, University of Melbourne, Australia Nanette Santoro, MD, University of Colorado, Denver, USA Natalia Gokina, PhD, University of Vermont, USA Virginia Winn, MD, PhD, Stanford University School of Nardhy Gomez-Lopez, PhD, Wayne State University, Medicine, USA USA Anthony Gregg, MD, University of Florida, USA

88 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL Save the Date: SRI-University of Edinburgh Symposium

THE UNIVERSITY of EDINBURGH

Centre for Reproductive Health Save the Date! August 16 18 2017, Edinburgh, Scotland, UK

Abstract Submission Deadline 10 May, 2017 REGISTRATION NOW OPEN Targeting In ammation to Improve RReproductiveeproductive Health Health Across Across the the Lifecourse Lifecourse

Dr Robert Taylor, Dr Elizabeth (Ebbie) Stewart, Wake Forrest School of Medicine, North Carolina Mayo Clinic College of Medicine Professor Sun Wei Go, Shanghi Professor Adriano Rossi, Dr Thomas Zollner, Bayer HealthCare, Germany Professor Chris Ponting, Dr Patrick Groothuis, Synthon Biopharmaceuticals B.V. MRC Human Genetics, University of Edinburgh Professor Gordon Smith, University of Cambridge Professor Philip Bennett, Imperial College, London Professor Charlie Gourlay, Dr Yuichiro Miura, Tohoku University, Sendai, Japan Edinburgh Cancer Research Centre, University of Edinburgh Professor Eva Dimitradis, Hudson Institute Melbourne Professor Neil Cerragher, MRC Centre for Reproductive Health, University of Edinburgh Institute of Genetics and Molecular Medicine, Professor Stephen Tong, Mercy Hospital, Melbourne University of Edinburgh Professor Heather Cubie, University of Edinburgh Professor Catherina Becker, Centre for Neuroregeneration,University of Edinburgh Professor Sarah Howie, University of Edinburgh

Further information: [email protected] www.ed.ac.uk/centre-reproductive-health/news-events-seminars/events/sri-symposium

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 89 SRI AWARDS

SRI Awards The Society for Reproductive Investigation is pleased to be able to provide the following awards at our 2017 Annual Scientific Meeting: SRI Lifetime Distinguished Service Award The SRI Lifetime Distinguished Service Award began in 2016, and is intended to recognize an individual who has made outstanding contributions to the Society and significant contributions to the field of reproductive medicine and women’s health. SRI Distinguished Scientist Award Presented annually to a senior member of the Society who has made significant and lasting contributions to the Society for scientific research in reproductive medicine. President’s Achievement Award Presented annually to a member of the Society whose record in scientific investigation is outstanding and assures a continued productive research career in the future. Laxmi Baxi Award Awarded to Ph.D. individuals who are either graduate students still in-training or postdoctoral fellows within five years of their Ph.D. degree to encourage young Ph.D. trainees to present their research at the SRI Annual Scientific Meeting. Two $1,000 travel awards will be given to the top abstracts in basic reproductive science and in translational reproductive science. The awardees receive a plaque, check and are honored at the SRI Annual Scientific Meeting. Frederick Naftolin Award for Mentorship Established in 2003 to recognize the contributions of a member of the Society to training and career development of investigators in the field of reproductive and women’s health. The award is named in honor of Dr. Naftolin, a former President of the Society and staunch advocate for creating a mechanism for the Society to celebrate outstanding service to our scientific community through excellence in mentoring. Rogerio A. Lobo Award Established in 2007 to recognize the most outstanding contribution to Reproductive Sciences by a member of the Society. The award is named in honor of Dr. Lobo, a former President of the Society and former Editor-in-Chief of the Journal of the Society for Gynecologic Investigation (JSGI) which is now Reproductive Sciences. Thomas McDonald Award The Thomas McDonald Foundation Travel Award acknowledges the highest ranked abstract by an investigator in-training within the field of fetal neuroscience. This award honors the legacy of Dr. McDonald, whose immense contributions to the field of obstetrics and gynecology focused upon the neuroendocrinology of the developing fetus, placental function, fetal brain development, and uterine contractility.

90 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL SRI Awards, continued Pfizer-SRI President’s Presenter’s Award Originally established to recognize the 25 most meritorious abstracts (either poster or oral presentation) submitted by investigators in-training, the award is used as a means by which to encourage young investigators to present their research at the meeting and to result in the submission of more and better abstracts by those who need encouragement to consider a research career. Fellows and those in both the pre and post-doctoral training are eligible to receive the award, which is generously funded by Pfizer. The 25 awardees will receive a certificate and a check, and along with their training directors will be honored at a reception. SRI President’s Presenter’s Awards The President’s Presenter’s Awards recognize the four highest ranked abstracts chosen for presentation at the President’s New Investigator Plenary Session. Giorgio Pardi Junior Scientist Award The Giorgio Pardi Junior Scientist Award recognizes the highest ranked abstract within the field of fetal medicine and placental function by an investigator in-training. This abstract will be presented following the President’s Address, and generously funded by the Giorgio Pardi Foundation, which supports young researchers in the field of obstetrics and gynecology and fosters worldwide scientific cooperation. Giorgio Pardi Foundation Travel Award The Giorgio Pardi Foundation Travel Awards provides a travel award to the most highly ranked abstracts submitted from investigators in-training from Italy. SRI Poster Awards Awarded to the 20 best Investigator In-Training Poster Presentations and presented during a ceremony at the SRI Annual Meeting.

All 2017 award recipients will be announced at the meeting.

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 91 About SRI

About SRI It started in 1953… when a small group of physician-scientists and a basic researcher studying hypertensive disorders of pregnancy proposed the formation of an “Eclampsia” or “Toxemia” society. Leaders of the group included Drs. Nicholas Assali, Leon Chesley, Edward Davis, William Dieckmann, Russel de Alverez, Louis Hellman, and Ernst Page. In Dr. Larry Longo’s book, A Short History of the Society for Gynecologic Investigation, he states that the “Society of University Gynecologists”, as it was first called, was organized “…to stimulate, encourage, and to provide opportunities for investigators in obstetrics and gynecology to enter into free exchange of ideas to the end of increasing knowledge and techniques in this field. It was intended primarily for individuals who are giving full or considerable time to teaching and research, either in obstetrics and gynecology or in the fields kindred or related thereto.” The first official meeting of the Society of University Gynecologists was held on June 15, 1953, at the Yale Club in New York City. The first annual meeting took place in December of 1953 in Cincinnati, OH, with a programmatic focus on toxemias of pregnancy. During this time, the leadership contemplated whether the name of the society was truly representative of the overarching interests of the members. While the name was formally changed to “Society for Gynecologic Investigation” at the annual meeting in Chicago in 1954, the topic was re-visited over the years, and in the summer of 2013, as a part of an SGI Executive Council strategic planning discussion, the name of the Society was re-evaluated, and in 2014 it was changed to the current, “Society for Reproductive Investigation.” The Society adopted its first journal in 1970, which was termed “Gynecological Investigation”, and became the society’s official publication, with Walter Hermann serving as Editor-in Chief. Publication was stopped shortly thereafter, in 1975. All SGI proceedings were subsequently published by the American Journal of Obstetrics and Gynecology, with Dan Mishell as the SGI Editor. The SGI re-initiated its own journal in 1994, The Journal of the Society for Gynecologic Investigation, with Roger Lobo as its first Editor. In 2007 under Hugh Taylor’s leadership, the Society’s journal has morphed again to its current title, Reproductive Sciences. From its initial roster of 15 members, the Society has grown in numbers and diversity, with 93 members in 1964 to nearly 300 members in 1978, and to the 2016 membership of almost 1,000 worldwide. One-third of the members are basic scientists and two-thirds are clinical investigators. SRI members conduct basic, translational and clinical investigation in the reproductive sciences and women’s health. Areas of focus include obstetrics, perinatology, reproductive genetics, gynecology, gynecologic oncology, reproductive endocrinology, reproductive physiology, biochemistry, pharmacology, immunology, epidemiology, reproductive infectious disease and reproductive stem cell and developmental biology. Many members hold esteemed government-level grants and serve on study sections and advisory councils for national agencies and private foundations.

92 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL About SRI, continued Mission Statement The mission of the Society of Reproductive Investigation (SRI) is to advance reproductive and women’s healthcare through outstanding basic, translational, and clinical science and by training and mentoring future generations of investigators. Membership Regular Membership may be conferred on those individuals who provide evidence of a doctorate degree (M.D., Ph.D., D.Pharm.) and evidence of at least two (2) years of research experience including, but not limited to, postdoctoral, basic science or clinical fellowship. While a minimum of two (2) years should have been spent in this research career, there is no requirement that the nominee should have worked at his/her current institution for two (2) years. Eligible individuals must be nominated. Upon election to membership the newly elected member and sponsoring member will be notified of the fact of his/her election. Associate Membership is for individuals involved in research and/or health care in Obstetrics and Gynecology, Reproductive Medicine and Biology, or allied fields. This category includes laboratory managers, technologists, clinical research nurses and study coordinators, medical marketing and promotion, non-academic-based researchers, pharmaceutical/biotechnology representatives, among others. Emeritus Membership Each member of the Society shall, upon reaching his/her sixty-fifth (65) birthday and working no more than 25 percent, provide a written statement in order to become eligible for “Emeritus” status. The member may elect to stay active for as long as he/she wishes. Once a member elects “emeritus status”, he/she shall be entitled to all the rights and privileges of the Society, but will not have to pay annual dues, will not be asked to vote, and will not be eligible to be a an elected officer. Honorary Membership in the SRI is awarded to an individual who has achieved recognition for scientific contributions of an original nature in reproductive biology in which he/she has personally actively participated. This person should have demonstrated by past performance and future objectives that this interest in reproductive biology is dynamic. The individual need not necessarily occupy a position in an institution of higher learning, nor necessarily function in a medical or paramedical area. Honorary Members shall enjoy all of the rights and privileges of other members of the Society, except that they shall not be required to pay any dues or assessments, shall not be entitled to vote at any regular or special meetings of members, nor to hold any elective or appointive office in the Society. In Training Membership is available for members who are not in a faculty position. They must be a full-time postdoctoral trainee, resident, fellow or student enrolled in a formal approved training program leading to a degree (B.A., B.S., M.D., Ph.D., M.S., M.P.H., and D.V.M.). Candidates will be proposed by a member in good-standing of the Society. The In Training member will pay nominal dues sufficient to cover administrative costs, may participate in all activities of the Society and subscribe to the Society’s journal if desired but may not sponsor abstracts or vote. This status expires when the member completes training at which time application for regular membership is expected.

FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL 93 SRI Council & Staff

SRI Council & Staff 2016 – 2017 Council President Council Members Yoel Sadovsky, MD Phillip R. Bennett, MD, PhD (2019) Magee-Women’s Research Institute Imperial College London Immediate Past President Elizabeth Ann Bonney, MD (2019) Hugh Taylor, MD University of Vermont Yale University Emmet Hirsch, MD (2017) President-Elect NorthShore University Health System Sandra T. Davidge, PhD Errol R. Norwitz, MD, PhD (2018) University of Alberta Tufts University President Nominee Yolanda Smith, MD, MS (2017) Murray D. Mitchell, DPhil, DSc University of Michigan University of Queensland Stacy Zamudio, PhD (2018) Secretary Treasurer Hackensack University MC Mark Phillippe, MD, MHCM (2017) In-Training Ad Hoc Council Member Massachusetts General Hospital (2017) Secretary Treasurer-Elect Emiel D. Post Uiterweer, MD, PhD Ian M. Bird, PhD (2020) University Medical Centre of Utrecht University of Wisconsin-Madison

Staff Anne Krolikowski, CAE Nicole Dahms, CMP Executive Director Meetings Manager ([email protected]) ([email protected]) Leah Miller Morgan Derby Associate Executive Director Membership and Communications Coordinator ([email protected]) ([email protected])

94 FINAL PROGRAM Society for Reproductive Investigation 64th Annual Scientific Meeting MARCH 15-18, 2017 ORLANDO, FL SRI Thanks 2017 Supporters

SRI Thanks Our 2017 Supporters

AbbVie

Bayer AG

Burroughs Wellcome Fund

Fondazione Giorgio Pardi

March of Dimes

Pfizer Inc Save the Date: SRI 2018 Annual Meeting

Society for Reproductive Investigation

SAVE THE DATE

65th Annual Scientific Meeting March 7 – 10, 2018 Hilton San Diego Bayfront San Diego, CA www.sri-online.org