IP Studies List - PART ** I ** Inorganic Phosphates (IP) Consortium - Company Owned Studies 03 July 2014 1 Source Study Organism Substance Sub ID CAS Nr

Home , Boron phosphate, Dipotassium phosphate

IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 1 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested Bernd Aldorf, copper-II-hydroxyphosphate 38 12158-74-6 9.1.1 Short term acute toxicity daphnia [v 7.1.1] BTA 2004 Acute toxicity Daphnia Daphnia B101a LAUS 04111001W201 Mr D. Kuhn, Dr 38 Francois copper-II-hydroxyphosphate 12158-74-6 8.5.1 Acute toxicity, oral [vi 6.5.1] Richeux 2004 Acute oral toxicity Rat Rat B101b Phycher (Laus) TAO423-PH-04/0329 sodium metaphosphate insoluble HO3PNa 11 10361-03-2 9.1.1 Short term acute toxicity daphnia [v 7.1.1] Dr. H. Lebertz 1999 Acute toxicity Daphnia Daphnia B12 Fresenius 98TE181175 diammonium phosphate 19 7783-28-0 9.1.1 Short term acute toxicity daphnia [v 7.1.1] Dr. H. Lebertz 1999 Acute toxicity Daphnia Daphnia B20 Fresenius 99TE029486 Bernd Aldorf, copper (II)-pyrophosphate 37 10102-90-6 9.1.1 Short term acute toxicity daphnia [v 7.1.1] BTA 2004 Acute toxicity Daphnia Daphnia B31a LAUS 04111002W201 Mr D. Kuhn, Dr 37 Francois copper (II)-pyrophosphate 10102-90-6 8.5.1 Acute toxicity, oral [vi 6.5.1] Richeux 2004 Acute oral toxicity Rat Rat B31b Phycher (Laus) TAO423-PH-04/0330 boron phosphate 46 13308-51-5 9.1.1 Short term acute toxicity daphnia [v 7.1.1] Dr. H. Lebertz 1999 Acute toxicity Daphnia Daphnia B38 Fresenius 98TE181172 ammonium polyphosphate 20 14728-39-3 9.1.1 Short term acute toxicity daphnia [v 7.1.1] Dr. H. Lebertz 1999 Acute toxicity Daphnia Daphnia B44 Fresenius 98TE181171 Becker J., Parke Effects on eye mucosa - albinos Cannon (for STPP 0 7758-29-4 8.2.1 In vivo eye irritation [vi 6.2.1] G. St. E. 1975 rabbits Rabbits C1 Mobil) M51-75, SE-6590 Becker J., Parke Cannon (for 0 STPP 7758-29-4 8.1.1 In vivo skin irritation [vi 6.1.1] G. St. E 1975 Skin irritation - albinos rabbits Rabbits C2 Mobil) M52-75, SE-6600 Vaishnav D.D., 0 Yurk J.J., Ives, STPP 7758-29-4 9.1.1 Short term acute toxicity daphnia [v 7.1.1] Wade B.A. 1990 Acute toxicity - Daphnia Daphnia F01 ESE Gainsville FMC I89-1084 W. Barta, T. STPP 0 7758-29-4 8.2.1 In vivo eye irritation [vi 6.2.1] Cascieri, 1986 Preliminary eye irritation - rabbits Rabbits F02 FMC Tox Lab FMC I86-917 STPP 0 7758-29-4 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1989 Skin irritation - rabbits Rabbits F03 FMC Tox Lab I88-1047 STPP 0 7758-29-4 8.5.1 Acute toxicity, oral [vi 6.5.1] Watt B 1997 Acute oral toxicity - Rats Rats F04 FMC Tox Lab I97-2169 Jackson G.C., 0 Hardy C.J., STPP 7758-29-4 8.5.2 Acute toxicity, inhalation [vi 6.5.2] Chanter D.O. 1989 Acute inhalation toxicity - Rats Rats F05 FMC Tox Lab I88-1011 Vaishnav D.D., 15 Yurk J.J., Ives, Tetrapotassium pyrophosphate 7320-34-5 9.1.1 Short term acute toxicity daphnia [v 7.1.1] Wade B.A. 1991 Acute toxicity Daphnia Daphnia F11 ESE Gainsville I 89-1092 Sodium hexametaphosphate 10 10124-56-8 9.1.1 Short term acute toxicity daphnia [v 7.1.1] Yurk J.J. 1993 Acute toxicity Daphnia Daphnia F12 ESE Gainsville I 92-1271 Dipotassium phosphate 13 7758-11-4 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1987 Skin irritation and toxicity rabbits Rabbits F13 FMC I 87-0952 Dipotassium phosphate 13 7758-11-4 8.5.3 Acute toxicity, dermal [vi 6.5.3] Freeman C 1987 Skin irritation and toxicity rabbits Rabbits F13 FMC I 87-0952 Tri-potassium phosphate 14 7778-53-2 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1987 Skin irritation and toxicity rabbits Rabbits F14 FMC I 87-0954 Tri-potassium phosphate 14 7778-53-2 8.5.3 Acute toxicity, dermal [vi 6.5.3] Freeman C 1987 Skin irritation and toxicity rabbits Rabbits F14 FMC I 87-0954 Mono-sodium phosphate 2 7558-80-7 8.2.1 In vivo eye irritation [vi 6.2.1] Freeman C 1987 Eye irritation rabbits Rabbits F15 FMC I 86-0923 Sodium hexametaphosphate 10 10124-56-8 8.2.1 In vivo eye irritation [vi 6.2.1] Freeman C 1986 Eye irritation rabbits Rabbits F16 FMC I 86-915 Mono-potassium phosphate 12 7778-77-0 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1990 Skin irritation rabbits Rabbits F17 FMC I 90-1131 Mono-potassium phosphate 12 7778-77-0 8.2.1 In vivo eye irritation [vi 6.2.1] Freeman C 1986 Eye irritation rabbits Rabbits F18 FMC I 86-0927 Potassium tri-polyphosphate 16 13845-36-8 8.2.1 In vivo eye irritation [vi 6.2.1] Freeman C 1987 Eye irritation rabbits Rabbits F19 FMC I 86-0928 Dipotassium phosphate 13 7758-11-4 8.2.1 In vivo eye irritation [vi 6.2.1] Freeman C 1987 Eye irritation rabbits Rabbits F20 FMC I 86-0929 Tetrapotassium pyrophosphate 15 7320-34-5 8.2.1 In vivo eye irritation [vi 6.2.1] Freeman C 1987 Eye irritation rabbits Rabbits F21 FMC I 86-0930 Di-sodium phosphate 3 7558-79-4 8.2.1 In vivo eye irritation [vi 6.2.1] Freeman C 1987 Eye irritation rabbits Rabbits F22 FMC I 86-0931 Di-potassium phosphate 13 7758-11-4 8.5.1 Acute toxicity, oral [vi 6.5.1] Freeman C 1987 Preliminary oral toxicity - Rats Rats F23 FMC I 87-0951 Di-potassium phosphate 13 7758-11-4 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1987 Skin irritation and toxicity rabbits Rabbits F24 FMC I 87-0952

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 2 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

Di-potassium phosphate 13 7758-11-4 8.5.3 Acute toxicity, dermal [vi 6.5.3] Freeman C 1987 Skin irritation and toxicity rabbits Rabbits F24 FMC I 87-0952 Tetra-potassium pyrophosphate 15 7320-34-5 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1988 Skin irritation rabbits Rabbits F25 FMC I 88-1006 Tetra-potassium pyrophosphate 15 7320-34-5 8.5.3 Acute toxicity, dermal [vi 6.5.3] Freeman C 1988 Skin toxicity rabbits Rabbits F26 FMC I 88-1007 Tetra-sodium pyrophosphate 7 7722-88-5 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1988 Skin irritation rabbits Rabbits F27 FMC I 88-1008 Phosphoric acid 48 7664-38-2 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1989 Skin irritation rabbits Rabbits F28 FMC I 88-1050 Mono-sodium phosphate 2 7558-80-7 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1990 Skin irritation rabbits Rabbits F29 FMC I 90-1132 Potassium tri-polyphosphate 16 13845-36-8 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1990 Skin irritation rabbits Rabbits F30 FMC I 90-1133 Sodium hexametaphosphate 10 10124-56-8 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1990 Skin irritation rabbits Rabbits F31 FMC I 90-1136 Tricalcium phosphate 24 1306-06-5 8.1.1 In vivo skin irritation [vi 6.1.1] Freeman C 1993 Skin irritation rabbits Rabbits F32 FMC I 93-1753 Mono-sodium phosphate 2 7558-80-7 8.5.2 Acute toxicity, inhalation [vi 6.5.2] Signorin J. 1993 Acute inhalation toxicity rats Rats F33 FMC I 93-1754 Sodium Acid Pyrophosphate 5 7758-16-9 8.5.2 Acute toxicity, inhalation [vi 6.5.2] Signorin J. 1993 Acute inhalation toxicity rats Rats F34 FMC I 93-1755 Sodium hexametaphosphate 10 10124-56-8 8.5.2 Acute toxicity, inhalation [vi 6.5.2] Signorin J. 1993 Acute inhalation toxicity rats Rats F35 FMC I 93-1756 Tetrapotassium pyrophosphate 15 7320-34-5 8.5.2 Acute toxicity, inhalation [vi 6.5.2] Signorin J. 1993 Acute inhalation toxicity rats Rats F36 FMC I 93-1757 “Natriumtripolyphosphat toxikologische prüfung” - Skin and 0 eye irritation - rats - Translation 2002 Fabwerke STPP 7758-29-4 8.1.1 In vivo skin irritation [vi 6.1.1] Dr. Weigand M. 1966 by Roth T., Clariant. Rats H1 Hoechst 1966.0093 “Natriumtripolyphosphat toxikologische prüfung” - Skin and 0 eye irritation - rats - Translation 2002 Fabwerke STPP 7758-29-4 8.2.1 In vivo eye irritation [vi 6.2.1] Dr. Weigand M. 1966 by Roth T., Clariant. Rats H1 Hoechst 1966.0093 "Ecotoxicilogie du tripolyphosphate 0 Herschke B., …" - Toxicity algae (fresh and sea algae (fresh and Rhône Poulenc STPP 7758-29-4 Growth inhibition of algae [v 7.1.2 ] Cellier 1985 water) sea water) R1 R Decines 614-9240

0 "Etude de la toxicité aquatique …" - Rhône Poulenc STPP 7758-29-4 9.1.1 Short term acute toxicity daphnia [v 7.1.1] Dion M 1985 Acute toxicity daphnia and zebra fish Daphnia R2 R Decines 614.9246

0 "Etude de la toxicité aquatique …" - Rhône Poulenc STPP 7758-29-4 9.1.3 Short term acute toxicity fish [v 7.1.3] Dion M 1985 Acute toxicity daphnia and zebra fish Zebra fish R2 R Decines 614.9246

0 Kamienski F. X., Acute oral (rat) and dermal toxicity, Stauffer Western STPP 7758-29-4 8.1.1 In vivo skin irritation [vi 6.1.1] C.H. Bullock 1971 skin and eye irritation (all rabbit) Rats & Rabbits S1 RC T-1713

0 Kamienski F. X., Acute oral (rat) and dermal toxicity, Stauffer Western STPP 7758-29-4 8.5.1 Acute toxicity, oral [vi 6.5.1] C.H. Bullock 1971 skin and eye irritation (all rabbit) Rats & Rabbits S1 RC T-1713

0 Kamienski F. X., Acute oral (rat) and dermal toxicity, Stauffer Western STPP 7758-29-4 8.5.3 Acute toxicity, dermal route [vi 6.5.3] C.H. Bullock 1971 skin and eye irritation (all rabbit) Rats & Rabbits S1 RC T-1713 sodium aluminum phosphate 43 7785-88-8 8.6.2 subchronic toxicity, oral [vi 6.5.1] Smith P.S. 1972 90 days subacute oral toxicity Rats BK1 Bio-test BTL-71-49 B sodium aluminum phosphate 43 7785-88-8 8.6.2 subchronic toxicity, oral [vi 6.5.1] Reyna M.S. 1973 90 days subacute oral toxicity Rats BK2 Bio-test BTL-71-49 D sodium aluminum phosphate 43 7785-88-8 8.6.1 Short-term repeated dose toxicity, oral Smith P.S. 1972 30 days pilot study Rats BK3 Bio-test BTL-71-49 A sodium aluminum phosphate 43 7785-88-8 8.6.2 90-day repeated-dose toxicity Mastalski K. 1972 90 days subacute oral toxicity Dogs BK4 Bio-test BTL-71-49 C Newell G.W, 5 Jorgenson T.A. sodium Acid Pyrophosphate 7758-16-9 8.4 in vivo Mutagenicity Simon V.F. 1974 Host-mediated assay mouse BK5 SRI SR85X062

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 3 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

Newell G.W, 5 Jorgenson T.A. sodium Acid Pyrophosphate 7758-16-9 8.4 In vitro Mutagenicity Simon V.F. 1974 in vitro microbial assay bacteria BK5 SRI SR85X062 Newell G.W, 5 Jorgenson T.A. sodium Acid Pyrophosphate 7758-16-9 8.4 in vivo Mutagenicity Simon V.F. 1974 dominant lethal test Rats BK5 SRI SR85X062 Newell G.W, 5 Jorgenson T.A. sodium Acid Pyrophosphate 7758-16-9 8.4 in vivo Mutagenicity Simon V.F. 1974 mouse translocation test mouse BK5 SRI SR85X062 Newell G.W, 5 Jorgenson T.A. Mutagenicity evaluation - precurser to sodium acid Pyrophosphate 7758-16-9 8.5.1 Acute toxicity, oral Simon V.F. 1974 RDL and mouse translocation Rat, Mouse BK5 SRI SR85X062 sodium Acid Pyrophosphate 5 7758-16-9 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK6 Younger Lab Y-73-79 acute skin absorption minimal lethal sodium Acid Pyrophosphate 5 7758-16-9 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK6 Younger Lab Y-73-79 sodium Acid Pyrophosphate 5 7758-16-9 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK6 Younger Lab Y-73-79 sodium Acid Pyrophosphate 5 7758-16-9 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK6 Younger Lab Y-73-79 deicer ID1352D mix NA 8.5.1 Acute toxicity, oral [vi 6.5.1] Younger F.M. 1965 single oral dose Rats BK7 Younger Lab Y-65-176 acute skin absorption minimal lethal deicer ID1352D mix NA 8.5.3 Acute toxicity, dermal Younger F.M. 1965 dose Rabbits BK7 Younger Lab Y-65-176 deicer ID1352D mix NA 8.1.1 In vivo skin irritation [vi 6.1.1] Younger F.M. 1965 Skin irritation - albinos rabbits Rabbits BK7 Younger Lab Y-65-176 deicer ID1352D mix NA 8.2.1 In vivo eye irritation [vi 6.2.1] Younger F.M. 1965 Eye irritation rabbits Rabbits BK7 Younger Lab Y-65-176 PhosCheck202 (diammonium phosphates mix) 19 7783-28-0 8.5.1 Acute toxicity, oral [vi 6.5.1] Younger F.M. 1965 single oral dose Rats BK8 Younger Lab Y-65-176 PhosCheck202 (diammonium acute skin absorption minimal lethal phosphates mix) 19 7783-28-0 8.5.3 Acute toxicity, dermal Younger F.M. 1965 dose Rabbits BK8 Younger Lab Y-65-176 PhosCheck202 (diammonium phosphates mix) 19 7783-28-0 8.1.1 In vivo skin irritation [vi 6.1.1] Younger F.M. 1965 Skin irritation - albinos rabbits Rabbits BK8 Younger Lab Y-65-176 PhosCheck202 (diammonium phosphates mix) 19 7783-28-0 8.2.1 In vivo eye irritation [vi 6.2.1] Younger F.M. 1965 Eye irritation rabbits Rabbits BK8 Younger Lab Y-65-176 diammonium phosphate 19 7783-28-0 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK9 Younger Lab Y-73-83 acute skin absorption minimal lethal diammonium phosphate 19 7783-28-0 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK9 Younger Lab Y-73-83 diammonium phosphate 19 7783-28-0 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK9 Younger Lab Y-73-83 diammonium phosphate 19 7783-28-0 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK9 Younger Lab Y-73-83 monoammonium phosphate 18 7722-76-1 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK10 Younger Lab Y-73-81 acute skin absorption minimal lethal monoammonium phosphate 18 7722-76-1 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK10 Younger Lab Y-73-81 Skin irritation - monoammonium phosphate 18 7722-76-1 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits albinos rabbits BK10 Younger Lab Y-73-81 monoammonium phosphate 18 7722-76-1 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK10 Younger Lab Y-73-81 trisodium phosphate 4 7601-54-9 8.1.1 In vivo skin irritation [vi 6.1.1] Younger F.M. 1962 Skin irritation - albinos rabbits Rabbits BK11 Younger Lab Y-62-69 part II trisodium phosphate 4 7601-54-9 8.2.1 In vivo eye irritation [vi 6.2.1] Younger F.M. 1962 Eye irritation rabbits Rabbits BK11 Younger Lab Y-62-69 part II trisodium phosphate 4 7601-54-9 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK12 Younger Lab Y-73-119 acute skin absorption minimal lethal trisodium phosphate 4 7601-54-9 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK12 Younger Lab Y-73-119 trisodium phosphate 4 7601-54-9 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK12 Younger Lab Y-73-119 trisodium phosphate 4 7601-54-9 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK12 Younger Lab Y-73-119

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 4 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

trisodium phosphate 4 7601-54-9 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1977 single oral dose Rats BK13 Younger Lab Y-77-27 acute skin absorption minimal lethal trisodium phosphate 4 7601-54-9 8.5.3 Acute toxicity, dermal Birch M.D. 1977 dose Rabbits BK13 Younger Lab Y-77-27 trisodium phosphate 4 7601-54-9 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1977 Skin irritation - albinos rabbits Rabbits BK13 Younger Lab Y-77-27 trisodium phosphate 4 7601-54-9 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1977 Eye irritation rabbits Rabbits BK13 Younger Lab Y-77-27 disodium phosphate 3 7558-79-4 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1972 skin irritation Rabbits BK14 Younger Lab Y-72-193 disodium phosphate 3 7558-79-4 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK15 Younger Lab Y-73-85 acute skin absorption minimal lethal disodium phosphate 3 7558-79-4 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK15 Younger Lab Y-73-85 disodium phosphate 3 7558-79-4 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK15 Younger Lab Y-73-85 disodium phosphate 3 7558-79-4 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK15 Younger Lab Y-73-85 monosodium phosphate 2 7558-80-7 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK16 Younger Lab Y-73-75 acute skin absorption minimal lethal monosodium phosphate 2 7558-80-7 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK16 Younger Lab Y-73-75 monosodium phosphate 2 7558-80-7 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK16 Younger Lab Y-73-75 monosodium phosphate 2 7558-80-7 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK16 Younger Lab Y-73-75 sodium trimetaphosphate 8 7785-84-4 8.5.1 Acute toxicity, oral [vi 6.5.1] Younger F.M. 1961 single oral dose Rats BK17 Younger Lab Y-61-83 sodium trimetaphosphate 8 7785-84-4 8.1.1 In vivo skin irritation [vi 6.1.1] Younger F.M. 1961 Skin irritation - albinos rabbits Rabbits BK17 Younger Lab Y-61-83 sodium trimetaphosphate 8 7785-84-4 8.2.1 In vivo eye irritation [vi 6.2.1] Younger F.M. 1961 Eye irritation rabbits Rabbits BK17 Younger Lab Y-61-83 insoluble sodium metaphosphate 11 10361-03-2 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK18 Younger Lab Y-73-76 acute skin absorption minimal lethal insoluble sodium metaphosphate 11 10361-03-2 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK18 Younger Lab Y-73-76 insoluble sodium metaphosphate 11 10361-03-2 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK18 Younger Lab Y-73-76 insoluble sodium metaphosphate 11 10361-03-2 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK18 Younger Lab Y-73-76 tetrasodium pyrophosphate 7 7722-88-5 8.1.1 In vivo skin irritation [vi 6.1.1] Younger F.M. 1962 Skin irritation - albinos rabbits Rabbits BK19 Younger Lab Y-62-70 tetrasodium pyrophosphate 7 7722-88-5 8.2.1 In vivo eye irritation [vi 6.2.1] Younger F.M. 1962 Eye irritation rabbits Rabbits BK19 Younger Lab Y-62-70 tetrasodium pyrophosphate 7 7722-88-5 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK20 Younger Lab Y-73-80 acute skin absorption minimal lethal tetrasodium pyrophosphate 7 7722-88-5 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK20 Younger Lab Y-73-80 tetrasodium pyrophosphate 7 7722-88-5 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK20 Younger Lab Y-73-80 tetrasodium pyrophosphate 7 7722-88-5 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK20 Younger Lab Y-73-80 monopotassium phosphate 12 7778-77-0 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK21 Younger Lab Y-73-117 acute skin absorption minimal lethal monopotassium phosphate 12 7778-77-0 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK21 Younger Lab Y-73-117 monopotassium phosphate 12 7778-77-0 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK21 Younger Lab Y-73-117 monopotassium phosphate 12 7778-77-0 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK21 Younger Lab Y-73-117 dipotassium phosphate 13 7758-11-4 8.2.1 In vivo eye irritation [vi 6.2.1] Blaszcak D.L. 1986 Eye irritation rabbits Rabbits BK22 Bio dynamics BD-86-191 dipotassium phosphate 13 7758-11-4 Acute oral toxicity Blaszcak D.L. 1986 Acute oral toxicity Rat BK22 Bio dynamics BD-86-191 dipotassium phosphate 13 7758-11-4 Acute dermal toxicity Blaszcak D.L. 1986 Acute dermal toxicity Rabbit BK22 Bio dynamics BD-86-191 Tripotassium phosphate 14 7778-53-2 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1976 single oral dose Rats BK23 Younger Lab Y-76-343 acute skin absorption minimal lethal Tripotassium phosphate 14 7778-53-2 8.5.3 Acute toxicity, dermal Birch M.D. 1976 dose Rabbits BK23 Younger Lab Y-76-343 Tripotassium phosphate 14 7778-53-2 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1976 Skin irritation - albinos rabbits Rabbits BK23 Younger Lab Y-76-343 Tripotassium phosphate 14 7778-53-2 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1976 Eye irritation rabbits Rabbits BK23 Younger Lab Y-76-343 tetrapotassium phosphate 15 7320-34-5 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK24 Younger Lab Y-73-114

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 5 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested acute skin absorption minimal lethal tetrapotassium phosphate 15 7320-34-5 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK24 Younger Lab Y-73-114 tetrapotassium phosphate 15 7320-34-5 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK24 Younger Lab Y-73-114 tetrapotassium phosphate 15 7320-34-5 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK24 Younger Lab Y-73-114 tetra-potassium pyrophosphate 15 7320-34-5 8.5.1 Acute toxicity, oral [vi 6.5.1] Younger F.M. 1961 single oral dose Rats BK25 Younger Lab Y-61-24 tetra-potassium pyrophosphate 15 7320-34-5 8.1.1 In vivo skin irritation [vi 6.1.1] Younger F.M. 1961 Skin irritation - albinos rabbits Rabbits BK25 Younger Lab Y-61-24 tetra-potassium pyrophosphate 15 7320-34-5 8.2.1 In vivo eye irritation [vi 6.2.1] Younger F.M. 1961 Eye irritation rabbits Rabbits BK25 Younger Lab Y-61-24 monocalcium Phosphate 21 7758-23-8 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK26 Younger Lab Y-73-113 acute skin absorption minimal lethal monocalcium Phosphate 21 7758-23-8 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK26 Younger Lab Y-73-113 monocalcium Phosphate 21 7758-23-8 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK26 Younger Lab Y-73-113 monocalcium Phosphate 21 7758-23-8 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK26 Younger Lab Y-73-113 dicalcium phosphate 22 7757-93-9 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1974 single oral dose Rats BK27 Younger Lab Y-74-225 acute skin absorption minimal lethal dicalcium phosphate 22 7757-93-9 8.5.3 Acute toxicity, dermal Birch M.D. 1974 dose Rabbits BK27 Younger Lab Y-74-225 dicalcium phosphate 22 7757-93-9 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1974 Skin irritation - albinos rabbits Rabbits BK27 Younger Lab Y-74-225 dicalcium phosphate 22 7757-93-9 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1974 Eye irritation rabbits Rabbits BK27 Younger Lab Y-74-225 dicalcium phosphate 22 7757-93-9 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK28 Younger Lab Y-73-50 acute skin absorption minimal lethal dicalcium phosphate 22 7757-93-9 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK28 Younger Lab Y-73-50 dicalcium phosphate 22 7757-93-9 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK28 Younger Lab Y-73-50 dicalcium phosphate 22 7757-93-9 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK28 Younger Lab Y-73-50 calcium pyrophosphate 26 7790-76-3 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1973 single oral dose Rats BK29 Younger Lab Y-73-116 acute skin absorption minimal lethal calcium pyrophosphate 26 7790-76-3 8.5.3 Acute toxicity, dermal Birch M.D. 1973 dose Rabbits BK29 Younger Lab Y-73-116 calcium pyrophosphate 26 7790-76-3 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1973 Skin irritation - albinos rabbits Rabbits BK29 Younger Lab Y-73-116 calcium pyrophosphate 26 7790-76-3 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1973 Eye irritation rabbits Rabbits BK29 Younger Lab Y-73-116 trimagnesium phosphate 30 7757-87-1 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1975 single oral dose Rats BK30 Younger Lab Y-75-182 acute skin absorption minimal lethal trimagnesium phosphate 30 7757-87-1 8.5.3 Acute toxicity, dermal Birch M.D. 1975 dose Rabbits BK30 Younger Lab Y-75-182 trimagnesium phosphate 30 7757-87-1 8.1.1 In vivo skin irritation [vi 6.1.1] Birch M.D. 1975 Skin irritation - albinos rabbits Rabbits BK30 Younger Lab Y-75-182 trimagnesium phosphate 30 7757-87-1 8.2.1 In vivo eye irritation [vi 6.2.1] Birch M.D. 1975 Eye irritation rabbits Rabbits BK30 Younger Lab Y-75-182 STPP 0 7758-29-4 8.1.1 In vivo skin irritation [vi 6.1.1] Younger F.M. 1962 Skin irritation - albinos rabbits Rabbits BK31 Younger Lab Y-62-71 STPP 0 7758-29-4 8.2.1 In vivo eye irritation [vi 6.2.1] Younger F.M. 1962 Eye irritation rabbits Rabbits BK31 Younger Lab Y-62-71 STPP 0 7758-29-4 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1976 acute oral toxicity – Rats Rats BK32 Younger Lab Y-76-234 STPP 0 7758-29-4 8.5.1 Acute toxicity, oral [vi 6.5.1] Birch M.D. 1976 acute oral toxicity – Rats Rats BK32 Younger Lab Y-76-234 etude des especes phosphatees en Monosodium orthophosphate 2 7558-80-7 hydrolysis Gaillot J.C. 1985 sortie de machine a laver water R3 448-6402 etude des especes phosphatees en Sodium pyrophosphate 5 7758-46-9 hydrolysis Gaillot J.C. 1985 sortie de machine a laver water R3 0 448-6402 etude des especes phosphatees en Sodium tripolyphosphate hexaydrate 0 7758-29-4 hydrolysis Gaillot J.C. 1985 sortie de machine a laver water R3 0 448-6402 orthophosphate NA 8.6.1 Short term repeated doses Hodge C.H. 1956 pilot toxicity test Rats H1 Uni Rochester sodium metaphosphate 10 10124-56-8 8.6.1 Short term repeated doses Hodge C.H. 1956 pilot toxicity test Rats H1 Uni Rochester 0 sodium tripolyphosphate 0 7758-29-4 8.6.1 Short term repeated doses Hodge C.H. 1956 pilot toxicity test Rats H1 Uni Rochester 0 sodium trimetaphosphate 8 7785-84-4 8.6.1 Short term repeated doses Hodge C.H. 1956 pilot toxicity test Rats H1 Uni Rochester 0 sodium tetrametaphosphate NA 20758-95-6 8.6.1 Short term repeated doses Hodge C.H. 1956 pilot toxicity test Rats H1 Uni Rochester 0

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 6 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

orthophosphate NA 0 8.6.1 Short term repeated doses Hodge C.H. 1956 pilot toxicity test Dogs H1 Uni Rochester 0 sodium metaphosphate 10 10124-56-8 8.6.1 Short term repeated doses Hodge C.H. 1956 pilot toxicity test Dogs H1 Uni Rochester 0 sodium tripolyphosphate 0 7758-29-4 8.6.1 Short term repeated doses Hodge C.H. 1956 pilot toxicity test Dogs H1 Uni Rochester 0 sodium trimetaphosphate 8 7785-84-4 8.6.1 Short term repeated doses Hodge C.H. 1956 pilot toxicity test Dogs H1 Uni Rochester 0 sodium tetrametaphosphate NA 20758-95-6 8.6.1 Short term repeated doses Hodge C.H. 1956 pilot toxicity test Dogs H1 Uni Rochester 0 sodium tripolyphosphate 0 7758-29-4 8.6.3 Long term oral tox Hodge C.H. 1959 chronic oral toxicity studies in rats Rats H2 Uni Rochester 0 sodium trimetaphosphate 8 7785-84-4 8.6.3 Long term oral tox Hodge C.H. 1960 chronic oral toxicity studies in rats Rats H4 Uni Rochester 0 sodium trimetaphosphate 8 7785-84-4 Acute tox - other (IP route) Hodge C.H. 1960 chronic oral toxicity studies in rats Rats H4 Uni Rochester 0 sodium hexametaphosphate 10 10124-56-8 8.6.3 Long term oral tox Hodge C.H. 1960 chronic oral toxicity studies in rats Rats H3 Uni Rochester 0 sodium hexametaphosphate 10 10124-56-8 8.5.1. Acute toxicity oral Hodge C.H. 1960 Acute oral toxicity Rats H3 Uni Rochester 0 sodium tripolyphosphate 0 7758-29-4 8.7.3 Reproductive toxicity multigeneration Hodge C.H. 1959 chronic oral toxicity studies in rats Rats H2 Uni Rochester 0 sodium hexametaphosphate 10 10124-56-8 8.7.3 Reproductive toxicity multigeneration Hodge C.H. 1960 chronic oral toxicity studies in rats Rats H3 Uni Rochester 0 sodium trimetaphosphate 8 7785-84-4 8.7.3 Reproductive toxicity multigeneration Hodge C.H. 1960 chronic oral toxicity studies in rats Rats H4 Uni Rochester 0 sodium tripolyphosphate 0 7758-29-4 8.9.1 Carcinogenicity Hodge C.H. 1959 chronic oral toxicity studies in rats Rats H2 Uni Rochester 0 sodium hexametaphosphate 10 10124-56-8 8.9.1 Carcinogenicity Hodge C.H. 1960 chronic oral toxicity studies in rats Rats H3 Uni Rochester 0 sodium trimetaphosphate 8 7785-84-4 8.9.1 Carcinogenicity Hodge C.H. 1960 chronic oral toxicity studies in rats Rats H4 Uni Rochester 0 phosphates NA Eutrophication De Madariaga 2007 Europhication risk assessment NA I3 INIA 0 Inhibition of the mobility of Daphnia sodium tripolyphosphate 0 7758-29-4 9.1.1 Short term acute toxicity daphnia [v 7.1.1] Pandard 2004 magna Daphnia I1 Ineris 50840a Inhibition of the mobility of sodium tripolyphosphate 0 7758-29-4 9.1.1 Short term acute toxicity daphnia [v 7.1.1] Pandard 2004 Ceriodaphnia dubia Ceriodaphnia I2 Ineris 50840b 8.3.2. Skin sensitisation in vivo test (LLNA first sodium tripolyphosphate 0 7758-29-4 choice method) Bradshaw J. 2008 local lymph node assay mouse STPP LLNA safepharm 2532/0002 Woolley A.j., sodium tripolyphosphate 0 7758-29-4 7.4. relative density Woolley S.M. 2008 determination of relative density material itself STPP density safepharm 2532/0001 P&G 0 P&G unpublished sodium tripolyphosphate 7758-29-4 8.3.2 Skin Sensitisation (Buehler method) P&G 1999 Buehler study Guinea pigs data toxicity studies on dicalcium Stauffer Western dicalcium phosphate 22 7757-93-9 8.5.1 acute toxicity, oral Kamienski FX 1970 phosphate Rat PS-2800 RC T-1624 toxicity studies on dicalcium Stauffer Western dicalcium phosphate 22 7757-93-9 8.5.1 subacute toxicity(14 day), oral Kamienski FX 1970 phosphate Rat PS-2800 RC T-1624 Pettersen JC, 43 Zwicker GM and 26-week subchronic toxicity study PS-2804 Stauffer Western sodium aluminum phosphate 7785-88-8 8.6.2 subchronic toxicity, oral Hackett DS 1987 with kasal in dogs Dog RC T-12969 trisodium phosphate trisodium phosphate, crystalline. Stauffer Western (dodecahydrate) 4 7601-54-9 8.5.1 Acute toxicity, oral Pontrepka RF 1981 Toxicity rat PS-2814 RC T-10656 trisodium phosphate trisodium phosphate, crystalline. Stauffer Western (dodecahydrate) 4 7601-54-9 8.5.3 Acute toxicity, dermal Pontrepka RF 1981 Toxicity rat PS-2814 RC T-10656 trisodium phosphate trisodium phosphate, crystalline. Stauffer Western (dodecahydrate) 4 7601-54-9 8.1.1 skin irritation in vivo Pontrepka RF 1981 Toxicity rat PS-2814 RC T-10656 trisodium phosphate trisodium phosphate, crystalline. Stauffer Western (dodecahydrate) 4 7601-54-9 8.2.1 eye irritation in vivo Pontrepka RF 1981 Toxicity rabbit PS-2814 RC T-10656

fish: Bluegill 4 PS-2814 trisodium phosphate trisodium phosphate, crystalline. and Rainbow Stauffer Western (dodecahydrate) 7601-54-9 9.1.3 short-term toxicity testing on fish Potrepka RF 1981 Toxicity trout RC T-10656

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 7 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested Stauffer Western by-product of phosphoric acid' n/a unknown 8.5.1 Acute toxicity, oral ? 1968 ? Rat PS-2818 RC T-1255 Acute oral toxicity of levn-lite in male Stauffer Western sodium aluminum phosphate 43 7785-88-8 8.5.1 Acute toxicity, oral Bullock CH 1970 rats Rat PS-2821 RC T-1627 Bullock CH and Stauffer Western Phosphoric acid 48 7664-38-2 8.2.1 eye irritation in vivo Kamienski FX. 1971 Toxicology lab report rabbit PS-2845 RC T-1731 Bullock CH and Stauffer Western Phosphoric acid 48 7664-38-3 8.1.1 skin irritation in vivo Kamienski FX. 1971 Toxicology lab report rabbit PS-2845 RC T-1731 Bullock CH and Stauffer Western Phosphoric acid 48 7664-38-2 8.1.1 skin irritation in vivo Kamienski FX. 1971 Toxicology lab report rabbit PS-2856 RC T-1777 Bullock CH and Stauffer Western Super phosphoric acid N/A ? 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2864 RC T-4050 Bullock CH and Stauffer Western diammonium phosphate 19 7783-28-0 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2865 RC T-4054 Bullock CH and Stauffer Western diammonium phosphate 19 7783-28-0 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054 Bullock CH and Stauffer Western monoaluminium phosphate 39 13530-50-2 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2865 RC T-4054 Bullock CH and Stauffer Western monoaluminium phosphate 39 13530-50-2 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054 Bullock CH and Stauffer Western monoammonium phosphate 18 7722-76-1 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2865 RC T-4054 Bullock CH and Stauffer Western monocalcium phosphate 21 7758-23-8 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054 Bullock CH and Stauffer Western monocalcium phosphate 21 7758-23-8 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2865 RC T-4054 monomagnesium phosphate Bullock CH and Stauffer Western (solution) 31 13092-66-5 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054 monomagnesium phosphate Bullock CH and Stauffer Western (solution) 31 13092-66-5 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2865 RC T-4054 Bullock CH and Stauffer Western monopotassium phosphate 12 7778-77-0 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2865 RC T-4054 Bullock CH and Stauffer Western Potassium tri-polyphosphate 16 13845-36-8 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2865 RC T-4054

43 Bullock CH and Stauffer Western sodium aluminum phosphate 7785-88-8 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2865 RC T-4054 Bullock CH and Stauffer Western Tetrapotassium pyrophosphate 15 7320-34-5 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2865 RC T-4054 Bullock CH and Stauffer Western tetrasodium pyrophosphate 7 7722-88-5 8.1.1 skin irritation in vivo Kamienski FX. 1972 Toxicology lab report rabbit PS-2865 RC T-4054 Bullock CH and Stauffer Western tetrasodium pyrophosphate 7 7722-88-5 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054 Bullock CH and Stauffer Western dipotassium phosphate 13 7785-11-4 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054 Bullock CH and Stauffer Western iron orthophosphate 27 10045-86-0 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054 Bullock CH and Stauffer Western monosodium phosphate 2 7558-80-7 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 8 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested Bullock CH and Stauffer Western sodium Acid Pyrophosphate 5 7758-16-9 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054 Bullock CH and Stauffer Western sodium hexametaphosphate 9 68915-31-1 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054 Bullock CH and Stauffer Western Tricalcium phosphate 24 7758-87-4 8.5.1 Acute toxicity, oral Kamienski FX. 1972 Toxicology lab report rat PS-2865 RC T-4054 Bullock CH and Stauffer Western polyphosphoric acid 49 8017-16-1 8.1.1 skin irritation in vivo Heil JF 1973 Toxicology lab report rabbit PS-2868 RC T-4176 trisodium phosphate - Henderson L Stauffer Western dodecahydrate 4 7601-54-9 8.1.1 skin irritation in vivo and Joiner RL 1974 Toxicology lab report rabbit PS-2882 RC T-4894 Henderson L Stauffer Western trisodium phosphate 4 7601-54-9 8.1.1 skin irritation in vivo and Joiner RL 1974 Toxicology lab report rabbit PS-2884 RC T-4896 Stauffer Western aluminum metaphosphate 42 13776-88-0 8.1.1 skin irritation in vivo Joiner RL 1975 Toxicology lab report rabbit PS-2914 RC T-5509 Stauffer Western aluminum metaphosphate 42 13776-88-0 8.5.1 Acute toxicity, oral Joiner RL 1975 Toxicology lab report rat PS-2914 RC T-5509 Stauffer Western monoaluminium phosphate 39 13530-50-2 8.5.1 Acute oral toxicity Joiner RL 1975 Toxicology lab report rat PS-2915 RC T-5510 Stauffer Western monoaluminium phosphate 39 13530-50-2 8.1.1 skin irritation in vivo Joiner RL 1975 Toxicology lab report rabbit PS-2915 RC T-5510 monomagnesium phosphate Stauffer Western (solution) 31 13092-66-5 8.5.1 Acute oral toxicity Joiner RL 1975 Toxicology lab report rat PS-2918 RC T-5594 monomagnesium phosphate Stauffer Western (solution) 31 13092-66-5 8.1.1 skin irritation in vivo Joiner RL 1975 Toxicology lab report rabbit PS-2918 RC T-5594 Stauffer Western tetrasodium pyrophosphate 7 7722-88-5 8.5.1 Acute toxicity, oral Jones B 1979 Toxicology lab report rat PS-2941 RC T-6816 Stauffer Western tetrasodium pyrophosphate 7 7722-88-5 8.5.3 Acute toxicity, dermal Jones B 1979 Toxicology lab report rabbit PS-2941 RC T-6816 Stauffer Western tetrasodium pyrophosphate 7 7722-88-5 8.1.1 skin irritation in vivo Jones B 1979 Toxicology lab report rabbit PS-2941 RC T-6816 Stauffer Western tetrasodium pyrophosphate 7 7722-88-5 8.2.1 eye irritation in vivo Jones B 1979 Toxicology lab report rabbit PS-2941 RC T-6816 A 6-moth sub-chronic dietary study Stauffer Western sodium aluminum phosphate 43 7785-88-8 8.6.2 Sub-chronic toxicity, 6 months Katz AC 1981 with LEVAIR in Beagle dogs dogs PS-2947 RC T-10195 sodium aluminum phosphate Stauffer Western (KASAL) 43 7785-88-8 8.5.1 Acute toxicity, oral Jones BJ 1980 Toxicology lab report rat PS-2948 RC T-10236 sodium aluminum phosphate Stauffer Western (KASAL) 43 7785-88-8 8.5.3 Acute toxicity, dermal Jones BJ 1980 Toxicology lab report rabbit PS-2948 RC T-10236 sodium aluminum phosphate Stauffer Western (KASAL) 43 7785-88-8 8.1.1 skin irritation in vivo Jones BJ 1980 Toxicology lab report rabbit PS-2948 RC T-10236 sodium aluminum phosphate Stauffer Western (KASAL) 43 7785-88-8 8.2.1 eye irritation in vivo Jones BJ 1980 Toxicology lab report rabbit PS-2948 RC T-10236 Stauffer Western Tricalcium phosphate 24 1306-06-5 8.5.1 Acute toxicity, oral Foster TL 1985 Toxicology lab report rat PS-2957 RC T-10619 Stauffer Western Tricalcium phosphate 24 1306-06-5 8.5.3 Acute toxicity, dermal Foster TL 1985 Toxicology lab report rabbit PS-2957 RC T-10619 Stauffer Western Tricalcium phosphate 24 1306-06-5 8.1.1 skin irritation in vivo Foster TL 1985 Toxicology lab report rabbit PS-2957 RC T-10619 Stauffer Western Tricalcium phosphate 24 1306-06-5 8.2.1 eye irritation in vivo Foster TL 1985 Toxicology lab report rabbit PS-2957 RC T-10619

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 9 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested 4-week dietary comparative toxicity Stauffer Western sodium aluminum phosphate 43 7785-88-8 8.6.1 short-term repeated dose, oral, 28-day Sprague GL 1986 study with KASAL in rats rat PS- 2969 RC T-12644 Hazleton Primary dermal irritation study of Laboratories. 4 PS-3258 trisodium phosphate trisodium phosphate dodecahydrate Sponsor Rhone- (dodecahydrate) 7601-54-9 8.1.1 skin irritation in vivo Glaza SM 1992 (saturated solution at 10°C) in rabbits rabbit Poulenc Inc HWI 20200523 Hazleton Primary dermal irritation study of Laboratories. 4 PS-3259 trisodium phosphate trisodium phosphate dodecahydrate Sponsor Rhone- (dodecahydrate) 7601-54-9 8.1.1 skin irritation in vivo Glaza SM 1992 (saturated solution at 22°C) in rabbits rabbit Poulenc Inc HWI 20200525 Hazleton Primary eye irritation study of Laboratories. 4 PS-3260 trisodium phosphate trisodium phosphate dodecahydrate Sponsor Rhone- (dodecahydrate) 7601-54-9 8.2.1 eye irritation in vivo Glaza SM 1992 (saturated solution at 10°C) in rabbits rabbit Poulenc Inc HWI 20200524 Acute oral toxicity in rats. Compound: Cannon (for Phosphoric acid 48 7664-38-2 8.5.1 Acute toxicity, oral ? 1975 MCTR-1-75 rat PS-3700 Mobil) M11-75 Acute oral toxicity in rats. Compound: Cannon (for Phosphoric acid 48 7664-38-2 8.5.1 Acute toxicity, oral ? 1975 MCTR-1-75 rat PS-3701 Mobil) M12-75 the acute dermal toxicity study of 48 Becker J and MCTR-1-75. New Zealand Albino PS-3702 Cannon (for Phosphoric acid 7664-38-2 8.5.3 Acute toxicity, dermal Parke G 1975 rabbits rabbit Mobil) M13-75

48 Becker J and The effects of MCTR-1-75 on the eye PS-3703 Cannon (for Phosphoric acid 7664-38-2 8.2.1 eye irritation, in vivo Parke G 1975 mucosa of new zealand abino rabbits rabbit Mobil) M14-75 A primary dermal irritation study of MCTR-1-75 on abraded and 48 PS-3704 Becker J and nonabraded skin of New Zealand Cannon (for Phosphoric acid 7664-38-2 8.1.1 skin irritation in vivo Parke G 1975 albino rabbits rabbit Mobil) M15-75 Terrell Y and Acute oral toxicity in rats. Compound: PS-3708 / Cannon (for 39 monaluminium phosphate 13530-50-2 8.5.1 Acute toxicity, oral Parke G 1975 MCTR-2-75 rat M21-75 Mobil) M0021-75 Terrell Y and Acute oral toxicity in rats. Compound: Cannon (for 14 PS-3709 Tripotassium phosphate 7778-53-2 8.5.1 Acute toxicity, oral Parke G 1975 MCTR-7-75 rat Mobil) M0071-75 /M71-75 Terrell Y and Acute oral toxicity in rats. Compound: Cannon (for Tripotassium phosphate 14 7778-53-2 8.5.1 Acute toxicity, oral Parke G 1975 MCTR-7-75 rat PS-3710 Mobil) M0072-75 / M72-75 Salmonella, S. Litton Bionetics 14 PS-3711 Tripotassium phosphate (liquid) 7778-53-2 8.4.1 In vitro mutagenicicty in bacteria Jagannath DR 1977 Mutagenicity evaluation of MCTR-258 cerevisiae (for Mobil) LBI project no: 20838 tetrapotassium pyrophosphate Imlay P and Report on the acute dermal toxicity of Cannon (for (liquid) 15 7320-34-5 8.5.3 Acute toxicity, dermal Parke G 1977 rabbits rabbit PS-3712 Mobil) M2571-77 Consumer 31 product testing magnesium phosphate (liquid) 10392-66-5 8.1.1 skin irritation in vivo Nitka S 1979 DOT skin corrosion in rabbits rabbit PS-3713 (for Mobil) M2270-79

31 The acute oral toxicity of magnesium Magnesium phosphate (solution) 10392-66-5 8.5.1 Acute toxicity, oral ? 1981 phosphate solution in albino rats rat PS-3714 Mobil M1171-81 The acute dermal toxicity of 31 magnesium phosphate solution in Magnesium phosphate (solution) 10392-66-5 8.5.3 Acute toxicity, dermal ? 1981 albino rabbits rabbit PS-3714 Mobil M1171-81

31 Primary eye irritation of magnesium Magnesium phosphate (solution) 10392-66-5 8.2.1 eye irritation in vivo ? 1981 phosphate solution in albino rabbits rabbit PS-3714 Mobil M1171-81

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 10 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

Skin irritation of magnesium 31 phosphate solution after a single Magnesium phosphate (solution) 10392-66-5 8.1.1 Skin irritation in vivo ? 1981 application to albino rabbits rabbit PS-3714 Mobil M1171-81 Terrel Y and Acute oral toxicity in rats. Compound: Cannon (for tetrapotassium pyrophosphate 15 7320-34-5 8.5.1 Acute toxicity, oral Parke G 1975 MCTR-6-75 rat PS-3732 Mobil) M62-75 Terrel Y and Acute oral toxicity in rats. Compound: Cannon (for tetrapotassium pyrophosphate 15 7320-34-5 8.5.1 Acute toxicity, oral Parke G 1975 MCTR-6-75 rat PS-3733 Mobil) M61-75 tetrapotassium pyrophosphate Salmonella, Litton Bionetics M2581-77 / LBI (liquid) 15 7320-34-5 8.4.1 Mutagenicity in bacteria Brusick DJ 1977 Mutagenicity evaluation of MCTR-257 S.cerevisiae PS-3734 Inc (for Mobil) No.20838 Imlay P and Report on the acute dermal toxicity of Cannon (for Tripotassium phosphate (liquid) 14 7778-53-2 8.5.3 Acute toxicity, dermal Parke G 1977 rabbits rabbit PS-3735 Mobil) M2582-77 Terrel Y and Acute oral toxicity in rats. Compound: Cannon (for dipotassium phosphate 13 7758--11-4 8.5.1 Acute toxicity, oral Parke G 1975 TDR-41-75 rat PS-3736 Mobil) M41-75 Terrel Y and Acute oral toxicity in rats. Compound: Cannon (for dipotassium phosphate 13 7758--11-4 8.5.1 Acute toxicity, oral Parke G 1975 MCTR-4-75 rat PS-3737 Mobil) M42-75 Imlay P and Report on the acute dermal toxicity of Cannon (for dipotassium phosphate 13 7758--11-4 8.5.3 Acute toxicity, dermal Parke G 1977 rabbits rabbit PS-3738 Mobil) M2562-77 Salmonella, Litton Bionetics M2561-77 / LBI No. dipotassium phosphate 13 7758--11-4 8.4.1 Mutagenicity in bacteria Jagannath DR 1977 Mutagenicity evaluation of MCTR-256 S.cerevisiae PS-3739 Inc (for Mobil) 20838

21 Acute toxicity test battery for Stauffer Western monocalcium phosphate 7758-23-8 8.5.1 Acute toxicity, oral Sorenson S 1985 monocalcium phosphate anhydrous rat PS-2815 RC T-12163

21 Acute toxicity test battery for Stauffer Western monocalcium phosphate 7758-23-8 8.5.3 Acute toxicity, dermal Sorenson S 1985 monocalcium phosphate anhydrous rabbit PS-2815 RC T-12164

21 Acute toxicity test battery for Stauffer Western monocalcium phosphate 7758-23-8 8.1.1 Skin irritation in vivo Sorenson S 1985 monocalcium phosphate anhydrous rabbit PS-2815 RC T-12165

21 Acute toxicity test battery for Stauffer Western monocalcium phosphate 7758-23-8 8.2.1 eye irritation in vivo Sorenson S 1985 monocalcium phosphate anhydrous rabbit PS-2815 RC T-12166 Stauffer Western sodium hypophosphite N/A N/A N/A Heil J 1974 N/A N/A PS-2824 RC T-4817 monoaluminium phosphate (50% Stauffer Western solution) 39 13530-50-2 8.1.1 Skin irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 monoaluminium phosphate (50% Stauffer Western solution) 39 13530-50-2 8.2.1 eye irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 monoaluminium phosphate (50% Stauffer Western solution) 39 13530-50-2 8.2.1 Acute toxicity, oral Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680 monoaluminium phosphate (50% Stauffer Western solution) 39 13530-50-2 8.5.3 Acute toxicity, dermal Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680 Stauffer Western tripotassium phosphate 14 7778-53-2 8.5.1 Acute toxicity, oral Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680 Stauffer Western tripotassium phosphate 14 7778-53-2 8.5.3 Acute toxicity, dermal Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western tripotassium phosphate 14 7778-53-2 8.1.1 Skin irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western tripotassium phosphate 14 7778-53-2 8.2.1 eye irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 11 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested Stauffer Western aluminium metaphosphate 42 13776-88-0 8.5.1 Acute toxicity, oral Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680 Stauffer Western aluminium metaphosphate 42 13776-88-0 8.5.3 Acute toxicity, dermal Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western aluminium metaphosphate 42 13776-88-0 8.1.1 Skin irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western aluminium metaphosphate 42 13776-88-0 8.2.1 eye irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western sodium iron pyrophosphate N/A 10045-87-1 8.5.1 Acute toxicity, oral Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680 Stauffer Western sodium iron pyrophosphate N/A 10045-87-1 8.5.3 Acute toxicity, dermal Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western sodium iron pyrophosphate N/A 10045-87-1 8.1.1 Skin irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western sodium iron pyrophosphate N/A 10045-87-1 8.2.1 eye irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western sodium trimetaphosphate 8 7785-84-4 8.5.1 Acute toxicity, oral Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680 Stauffer Western sodium trimetaphosphate 8 7785-84-4 8.5.3 Acute toxicity, dermal Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western sodium trimetaphosphate 8 7785-84-4 8.1.1 Skin irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western sodium trimetaphosphate 8 7785-84-4 8.2.1 eye irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western potassium polymetaphosphate N/A ? 8.5.1 Acute toxicity, oral Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680 Stauffer Western potassium polymetaphosphate N/A ? 8.5.3 Acute toxicity, dermal Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western potassium polymetaphosphate N/A ? 8.1.1 Skin irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western potassium polymetaphosphate N/A ? 8.2.1 eye irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western tetrapotassium pyrophosphate 15 7320-34-5 8.5.1 Acute toxicity, oral Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680 Stauffer Western tetrapotassium pyrophosphate 15 7320-34-5 8.5.3 Acute toxicity, dermal Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western tetrapotassium pyrophosphate 15 7320-34-5 8.1.1 Skin irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western tetrapotassium pyrophosphate 15 7320-34-5 8.2.1 eye irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western potassium tripolyphosphate 16 13845-36-8 8.5.1 Acute toxicity, oral Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680 Stauffer Western potassium tripolyphosphate 16 13845-36-8 8.5.3 Acute toxicity, dermal Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western potassium tripolyphosphate 16 13845-36-8 8.1.1 Skin irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western potassium tripolyphosphate 16 13845-36-8 8.2.1 eye irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western monopotassium phosphate 12 7778-77-0 8.5.1 Acute toxicity, oral Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 12 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested Stauffer Western monopotassium phosphate 12 7778-77-0 8.5.3 Acute toxicity, dermal Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western monopotassium phosphate 12 7778-77-0 8.1.1 Skin irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western monopotassium phosphate 12 7778-77-0 8.2.1 eye irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western Magnesium phosphate (solution) 31 13092-66-5 8.5.1 Acute toxicity, oral Kamienski FX 1971 Toxicology lab report rat PS-2839 RC T-1680 Stauffer Western Magnesium phosphate (solution) 31 13092-66-5 8.5.3 Acute toxicity, dermal Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western Magnesium phosphate (solution) 31 13092-66-5 8.1.1 Skin irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western Magnesium phosphate (solution) 31 13092-66-5 8.2.1 eye irritation in vivo Kamienski FX 1971 Toxicology lab report rabbit PS-2839 RC T-1680 Stauffer Western sodium aluminium phosphate 43 7785-88-8 8.2.1 eye irritation in vivo n/a n/a PS-2855 RC T-1775 Bullock CH and Stauffer Western sodium hexametaphosphate 10 68915-31-1 8.1.1 skin irritation in vivo Kamienski FX 1972 Toxicology lab report rabbit PS-2860 RC T-1861 Bullock CH and Stauffer Western dicalcium phosphate 22 7757-93-9 8.1.1 skin irritation in vivo Kamienski FX 1972 Toxicology lab report rabbit PS-2860 RC T-1861 Bullock CH and Stauffer Western dipotassium phosphate 13 7758--11-4 8.1.1 skin irritation in vivo Kamienski FX 1972 Toxicology lab report rabbit PS-2860 RC T-1861 Bullock CH and Stauffer Western disodium phosphate 3 7558-79-4 8.1.1 skin irritation in vivo Kamienski FX 1972 Toxicology lab report rabbit PS-2860 RC T-1861 Bullock CH and Stauffer Western ferric orthophosphate 27 10045-86-0 8.1.1 skin irritation in vivo Kamienski FX 1972 Toxicology lab report rabbit PS-2860 RC T-1861 Bullock CH and Stauffer Western insoluble sodium metaphosphate 11 10361-03-2 8.1.1 skin irritation in vivo Kamienski FX 1972 Toxicology lab report rabbit PS-2860 RC T-1861 Bullock CH and Stauffer Western monosodium phosphate 2 7558-80-7 8.1.1 skin irritation in vivo Kamienski FX 1972 Toxicology lab report rabbit PS-2860 RC T-1861 Bullock CH and Stauffer Western sodium trimetaphosphate 8 7785-84-4 8.1.1 skin irritation in vivo Kamienski FX 1972 Toxicology lab report rabbit PS-2860 RC T-1861 Bullock CH and Stauffer Western tricalcium phosphate 24 1306-06-5 8.1.1 skin irritation in vivo Kamienski FX 1972 Toxicology lab report rabbit PS-2860 RC T-1861 Bullock CH and Stauffer Western trimagnesium phosphate 30 7757-87-1 8.1.1 skin irritation in vivo Kamienski FX 1972 Toxicology lab report rabbit PS-2860 RC T-1861 Henderson L Stauffer Western monocalcium phosphate 21 7758-23-8 8.1.1 Skin irritation in vivo and Joiner RL 1974 Toxicology lab report rabbit PS-2894 RC T-4984

Calcium phosphates, calcium sulfate 21 and calcium carbonate bioavailability Stauffer Western monocalcium phosphate 7758-23-8 8.8.1 Toxicokinetics Killenger JM 1986 and disposition in rats. rat PS-2967 RC T-11722

Calcium phosphates, calcium sulfate 22 and calcium carbonate bioavailability Stauffer Western dicalcium phosphate 7757-93-9 8.8.1 Toxicokinetics Killenger JM 1986 and disposition in rats. rat PS-2967 RC T-11722

Calcium phosphates, calcium sulfate 24 and calcium carbonate bioavailability Stauffer Western tricalcium phosphate 1306-06-5 8.8.1 Toxicokinetics Killenger JM 1986 and disposition in rats. rat PS-2967 RC T-11722

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 13 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested Henderson L Stauffer Western calcium pyrophosphate 26 7790-76-3 8.1.1 Skin irritation in vivo and Joiner RL 1974 Toxicology lab report rabbit PS-2883 RC T-4895 Primary eye irritation study of trisodium phosphate dodecahydrate Hazelton (for 4 trisodium phosphate (saturated solution at 22 degC) in Rhone-Poulenc (doedecahydrate) 7601-54-9 8.2.1 eye irritation in vivo Glaza SM 1992 rabbits rabbit PS-3261 Inc) HWI 20200526 Consumer 48 A dermal corrosion study in albino product testing phosphoric acid 7664-38-2 8.1.1 Skin irritation in vivo Lewis CA 1979 rabbits. Compound: MCTR-67-79 rabbit PS-3705 (for Mobil) study no: 79230-1 Imlay P and Report on rabbit eye irritation Cannon (for Phosphoric acid? 48 7664-38-2 8.2.1 eye irritation in vivo Parke G 1977 Compound: MCTR-192-77 rabbit PS-3706 Mobil) M1923-77 Terrel Y and Report on Oral LD50 in rats. Cannon (for Phosphoric acid? 48 7664-38-2 8.5.1 Acute toxicity, oral Parke G 1977 Compound: MCTR-192-77 rat PS-3707 Mobil) lab no. 7E-7003 A primary dermal irritation study of MCTR-5-75 on abraded and 0 Becker J and nonabradedc skin of New Zealand Cannon (for sodium tripolyphosphate 7758-29-4 8.1.1 Skin irritation in vivo Parke G 1975 albino rabbits rabbit PS-3783 Mobil) lab no. 7E-6600 The effects of MCTR-5-75 on the eye 0 Becker J and mucosa of New Zealand albino Cannon (for sodium tripolyphosphate 7758-29-4 8.2.1 eye irritation in vivo Parke G 1975 rabbits rabbit PS-3784 Mobil) lab no. 7E-6599 Inveresk 20 AMGARD LR2: Acute toxicity (LD50) AW_1990a Research Int. ammonium polyphosphate 68333-79-9 8.5.1 Acute oral toxicity Cuthbert JA 1990 test in rats rat (for A&W) IRI-5910 Inveresk 20 AMGARD LR2: Acute dermal irritation AW_1990b Research Int. ammonium polyphosphate 68333-79-9 8.5.3 Acute toxicity, dermal Cuthbert JA 1990 test in rabbits rabbit (for A&W) IRI-5915 AMGARD LR2: Magnusson & 20 Kligman maximisation study in the AW_1993a Safepharm (for ammonium polyphosphate 68333-79-9 8.3 Skin senstisation Tomlinson PP 1993 Guinea pig Guinea pigs A&W) 71/154 AMGARD LR4: Acute oral toxicity Safepharm (for ammonium polyphosphate 20 68333-79-9 8.5.1 Acute toxicity, oral Guest RL 1993 (Limit test) in the rat rat AW_1993c A&W) 71/160 AMGARD LR2: Acute eye irritation Safepharm (for ammonium polyphosphate 20 68333-79-9 8.2.1 eye irritation in vivo Tomlinson PP 1993 test in the rabbit rabbit AW_1993b A&W) 71/155 AMGARD LR4: acute dermal toxicity Safepharm (for ammonium polyphosphate 20 68333-79-9 8.5.3 Acute toxicity, dermal Guest RL 1993 (Limit test) in the rat rat AW_1993d A&W) 71/161 AMGARD LR4: Magnusson & 20 Kligman maximisation study in the AW_1993e Safepharm (for ammonium polyphosphate 68333-79-9 8.3 Skin senstisation Tomlinson PP 1993 guinea pig Guinea pigs A&W) 71/162 AMGARD LR4: Acute dermal irritation Safepharm (for ammonium polyphosphate 20 68333-79-9 8.5.3 Acute toxicity, dermal Tomlinson PP 1993 test in the rabbit rabbit AW_1993f A&W) 71/163 AMGARD LR4: Acute eye irritation Safepharm (for ammonium polyphosphate 20 68333-79-9 8.2.1 eye irritation in vivo Tomlinson PP 1993 test in the rabbit rabbit AW_1993g A&W) 71/164 AMGARD MC(M): Acute inhalation 20 toxicity study four-hour exposure AW_1993h Safepharm (for ammonium polyphosphate 68333-79-9 8.5.2 Acute toxicity, inhalation Tomlinson PP 1993 (nose only) in the rat rat A&W) 71/167 AMGARD LR2: Acute dermal toxicity Safepharm (for ammonium polyphosphate 20 68333-79-9 8.5.3, Acute toxicity, dermal Snell K 1994 (Limit test) in the rat rat AW_1994 A&W) 71/320 AMGARD LR2: reverse mutation 20 assay "AMES TEST" using Salmonella AW_1995 Safepharm (for ammonium polyphosphate 68333-79-9 8.4.1 Mutagenicity in bacteria Thompson PW 1995 Salmonella typhimurium typhimurium A&W) 071/385

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Inveresk 20 Cutherbert JA Three flame retardant formulations. A AW_1996 Research Int. ammonium polyphosphate 68333-79-9 8.3 Skin senstisation and Neilson L 1996 human skin patch test (46h exposure) human (for A&W) IRI: 591521 The effects of MCTR-4-75 on the eye 13 Terrel Y and mucosa of New Zealand albino Cannon (for dipotassium phosphate 7758-11-4 8.2.1 eye irritation Parke G 1975 rabbits rabbit 11_AW Mobil) M43-75 A primary dermal irritation study of MCTR-4-75 on abraded and 13 12_AW Becker J and nonabraded skin of New Zealand Cannon (for dipotassium phosphate 7758-11-4 8.1. skin irritation in vivo Parke G 1975 albino rabbits rabbit Mobil) M44-75 Salmonella Litton Bionetics 13 25_AW dipotassium phosphate 7758-11-4 8.4 mutagenicity in bacteria Jagannath DR 1977 Mutagenicity evaluation of MCTR-256 typhimurium (for Mobil) M2561-77 / LBI: 20838 Anorganisches phosphoric acid 48 7664-38-2 8.5.1 Acute toxicity, oral ? ? ? ? 1964_0093 Laboratorium 93/64? Scholz and Toxikologische Prüfung von Farbwerke phosphoric acid 48 7664-38-2 8.5.1 Acute toxicity, oral Weigand 1967/68 reinigerkomponenten rat 1968_0111 Hoehst AG 111/68 Scholz and Farbwerke phosphoric acid 48 7664-38-2 ? Weigand 1971? Pastöse Phosphorsäure. VP Kn 500 ? 1971/0130 Hoehst AG 0130/71 Phosorige Säure Prüng auf phosphoric acid 48 7664-38-2 8.1.1 Skin irritation in vivo (?) Weigand W 1985 Hautreizung am Kaninchen rabbit 1985-0015 Hoechst 85.0015

AW_acute 48 Imlay P and Report on the acute dermal toxicity of Cannon (for dermal… phosphoric acid 7664-38-2 8.5.3 Acute toxicity, dermal Parke G 1977 rabbits Compound: MCTR-192-77 rabbit Mobil) M1922-77 Imlay P and Report on oral LD50 in rats. AW_Oral Cannon (for 48 phosphoric acid 7664-38-2 8.5.1 Acute toxicity, oral Parke G 1977 Compound: MCTR-192-77 rat LD50…. Mobil) M1921-77 Report on primary dermal irritation AW_Primary 48 Imlay P and study in rabbits. Compound: MCTR- Cannon (for dermal… phosphoric acid 7664-38-2 8.1.1 Skin irritation in vivo Parke G 1977 192-77 rabbit Mobil) M1924-77 Becker J and Report on rabbit eye irritation Cannon (for phosphoric acid 48 7664-38-2 8.2.1 eye irritation Parke G 1976 Compound: MCTR-51-76 rabbit CL_M511-76 Mobil) M511-76 Report on primary dermal irritation 48 Becker J and study in rabbits. Compound: MCTR- CL_M512-76 Cannon (for phosphoric acid 7664-38-2 8.1.1 Skin irritation in vivo Parke G 1976 51-76 rabbit Mobil) M512-76 polyphosphoric acid 49 8017-16-1 8.5.1 Acute toxicity, oral Weigand W 1972 ? rat 1972-0005 ? 0052/72 Berict über die Prüfung der haut - und schleimhautverträglichkeit von 3 49 1973-0202 emulgatoren und einem Farbwerke polyphosphoric acid 8017-16-1 8.1.1 skin irritation in vivo ? 1973 reaktionsprodukt am kaninchen rabbit Hoehst AG 0202/73 The effects of MCTR-6-75 on the eye 15 mucosa of New Zealand albino 17_AW Cannon (for tetrapotassium pyrophosphate 7320-34-5 8.2.1 eye irritation in vivo Parke G 1975 rabbits rabbit Mobil) M63-75 A primary dermal irritation study of MCTR-6-75 on abraded and 15 CL_M44-75 Becker J and nonabraded skin of F New Zealand Cannon (for tetrapotassium pyrophosphate 7320-34-5 8.1.1 skin irritation Parke G 1975 albino rabbits. rabbit Mobil) M64-75 The effects of MCTR-7-75 on the eye 14 mucosa of New Zealand albino 4_AW Cannon (for tripotassium phosphate 7778-53-2 8.2.1 eye irritation in vivo Parke G 1975 rabbits rabbit Mobil) M73-75 Terrell Y and Acute oral toxicity in rats. Compound: Cannon (for Tripotassium phosphate 14 7778-53-2 8.5.1 Acute toxicity, oral Parke G 1975 MCTR-7-75 rat 19_AW Mobil) M0071-75 /M71-75

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 15 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

A primary dermal irritation study of MCTR-7-75 on abraded and 14 22_AW Becker J and nonabraded skin of New Zealand Cannon (for tripotassium phosphate 7778-53-2 8.1.1 skin irritation in vivo Parke G 1975 albino rabbits rabbit Mobil) M74-75 Salmonella, Litton Bionetics M2581-77 / LBI 14 tripotassium phosphate 7778-53-2 8.4.1 Mutagenicity in bacteria Jagannath DR 1977 Mutagenicity evaluation of MCTR-258 S.cerevisiae 27_AW Inc (for Mobil) No.20838

39 the effects of MCTR-2-75 on the eye M22-75 Cannon (for monaluminium phosphate 13530-50-2 8.2.1 eye irritation in vivo Parke G 1975 mucosa of New Zealand albino rabbit rabbit Mobil) M22-75 A primary dermal irritation study of MCTR-2-75 on abraded and 39 M23-75 Becker J and nonabraded skin of New Zealand Cannon (for monaluminium phosphate 13530-50-2 8.1.1 skin irritation in vivo Parke G 1975 albino rabbits rabbit Mobil) M23-75

39 the effects of MCTR-20-75 on the eye Cannon (for monaluminium phosphate 13530-50-2 8.2.1 eye irritation in vivo Parke G 1975 mucosa of New Zealand albino rabbit rabbit M201-75 Mobil) M201-75 A primary dermal irritation study of MCTR-20-75 on abraded and 39 M202-75 nonabraded skin of New Zealand Cannon (for monaluminium phosphate 13530-50-2 8.1.1 skin irritation in vivo Parke G 1975 albino rabbits rabbit Mobil) M202-75 90-day subacute oral toxicity study Bio Lab (for sodium aluminum phosphate 43 7785-88-8 8.6.2 subchronic, 90-day, oral Smith PS 1972 with LEVAIR in albino rats rat PS-2751 Stauffer) T-6685 /IBT no. B747 90-day subacute oral toxicity study Bio Lab (for sodium aluminum phosphate 43 7785-88-8 8.6.2 subchronic, 90-day, oral Smith PS 1972 with KASAL in albino rats rat PS-2807 Stauffer) T-6686, IBT B747

43 90-day subacute oral toxicity study PS-2808 Bio Lab (for sodium aluminum phosphate 7785-88-8 8.6.2 subchronic, 90-day, oral Reyna MS 1973 with LEVAIR in female albino rats rat Stauffer) T-6684 90-day subacute oral toxicity study Bio Lab (for sodium aluminum phosphate 43 7785-88-8 8.6.2 subchronic, 90-day, oral Mastalski K. 1972 with LEVAIR in Beagle dogs dog PS-2809 Stauffer) T-6503 / IBT J749 90-day subacute oral toxicity study Bio Lab (for sodium aluminum phosphate 43 7785-88-8 8.6.2 subchronic, 90-day, oral Mastalski K. 1972 with KASAL in Beagle dogs dog PS-2934 Stauffer) T-6687 / IBT: J749 Product Safety DSW potassium pentahydrogen 55 Acute dermal toxicity study in rats - Laboratories (for IP55…19316 bis(phosphate) 14887-42-4 8.5.3 Acute toxicity, dermal Moore GE 2006 Limit test rat DSW) Lab no: 19316 Product Safety DSW potassium pentahydrogen 55 Laboratories (for IP55…19317 bis(phosphate) 14887-42-4 8.2.1 eye irritation in vivo Moore GE 2006 Primary eye irritation study in rabbits rabbit DSW) Lab no: 19317 Product Safety DSW potassium pentahydrogen 55 Laboratories (for IP55…19315 bis(phosphate) 14887-42-4 8.5.1 Acute toxicity, oral Moore GE 2006 Acute toxicity up and down procedure rat DSW) Lab no: 19315 Product Safety DSW potassium pentahydrogen 55 Laboratories (for IP55…19318 bis(phosphate) 14887-42-4 8.1.1 skin irritation in vivo Moore GE 2006 Primary skin irritation study in rabbits rabbit DSW) Lab no: 19318 Institut fur Biologische 50796185 55 Determination of the water solubility analytik (For final.pdf potassium pentahydrogen of potassium pentahydrogen Rotem Amfert bis(phosphate) 14887-42-4 Water solubility Mollandin G 2009 bis(phosphate) n/a Negev LTD) project No: 50796185

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Institut fur Biologische 50790194 55 Determination of the dissociation analytik (For Final.pdf potassium pentahydrogen constant of potassium pentahydrogen Rotem Amfert bis(phosphate) 14887-42-4 Dissociation constant Fieseler A 2009 bis(phosphate) in water n/a Negev LTD) project No: 50790194 Institut fur Biologische Determination of the relative density analytik (For of potassium pentahydrogen Rotem Amfert relative density Fieseler A 2009 bis(phosphate) n/a Negev LTD) project No: 50794182 Zaklady 39 Chemiczne monoaluminum phosphate 13530-50-2 8.5.1 Acute toxicity, oral Kazimerierz Kita 2001 ? rat Alwenia OS-36/01? Zaklady 39 Chemiczne monoaluminum phosphate 13530-50-2 8.5.3 Acute toxicity, dermal Kazimerierz Kita 2001 ? rabbit Alwenia OS-36/01? Zaklady 39 Chemiczne monoaluminum phosphate 13530-50-2 8.1.1 skin irritation Kazimerierz Kita 2001 ? rabbit Alwenia OS-36/01? Acute toxicity of ammonium phosphate sulfate to the rainbow N/A trout, Onchorhynchus mykiss, TFI/EFMA dertermined under static test fish: Rainbow Ammonium phosphate sulfate 12593-60-1 9.1.3 Short--term toxicity testing on fish ? 2000 conditions trout ABC laboratories 46203 Acute oral toxicity up and down Ammonium phosphate sulfate N/A 12593-60-1 8.5.1 Acute toxicity, oral ? 2000 procedure in rats rat TFI/EFMA ABC laboratories 9732 Toxicity of diammonium phosphate 19 (DAP) to unicellular green alga, TFI/EFMA diammonium phosphate 7783-28-0 9.1.2 Growth inhibition study in aquatic plants ? 2000 Selenastrum capricornutum Algae ABC laboratories 46207 In vitro mammalian chromosome diammonium phosphate 19 7783-28-0 8.4.2 In vitro cytogenicity study in mammalian cells ? 2000 abberation test N/A TFI/EFMA BioReliance AA43RB.331.BTL Acute oral toxicity up and down diammonium phosphate 19 7783-28-0 8.5.1 Acute toxicity, oral ? 2000 procedure in rats rat TFI/EFMA ABC laboratories 9733 4-week general toxicity and 19 8.7.1 Screening for reproductive developmental reproductive / development toxicity TFI/EFMA diammonium phosphate 7783-28-0 toxicity ? 2002 screening test ? HLS 22948 diammonium phosphate 19 7783-28-0 8.4.1 Mutagenicity in bacteria ? 2001 Bacterial reverse mutation assay ? TFI/EFMA BioReliance A43RB.503.BTL Acute dermal toxicity study in rats - Product Safety diammonium phosphate 19 7783-28-0 8.5.3 Acute toxicity, dermal ? 2000 Limit test ? TFI/EFMA Laboratories 9734

Acute toxicity of liquid polyphosphate 20 to the rainbow trout, Onchorhynchus TFI/EFMA mykiss, dertermined under static test Product Safety Liquid ammonium polyphosphate 68333-79-9 9.1.3 Short-term toxicity testing on fish ? 2000 conditions ? Laboratories 9736 Acute oral toxicity up and down Product Safety Liquid ammonium polyphosphate 20 68333-79-9 8.5.1 Acute toxicity, oral ? 2000 procedure in rats ? TFI/EFMA Laboratories 9735 Acute dermal toxicity study in rats - Product Safety monoammonium phosphate 18 7722-76-1 8.5.3 Acute toxicity, dermal ? 2000 Limit test ? TFI/EFMA Laboratories 9738

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 17 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

Acute toxicity of monoammonium 18 phosphate to the rainbow trout, TFI/EFMA Onchorhynchus mykiss, dertermined monoammonium phosphate 7722-76-1 9.1.3 Short-term toxicity testing on fish ? 2000 under static test conditions ? ABC laboratories 46201 Acute oral toxicity up and down Product Safety monoammonium phosphate 18 7722-76-1 8.5.1 Acute toxicity, oral ? 2000 procedure in rats ? TFI/EFMA Laboratories 9737 Toxicity of granular triple sugar phosphate (GTSP) to unicellular N/A TFI/EFMA Aufderheide JA, green alga, Selenastrum TSP 65995-95-4 9.1.2 Growth inhibition study in aquatic plants Bussard JB 2000 capricornutum (OECD 201) Algae ABC laboratories 46208 Gudi R & Brown In vitro mammalian chromosome Mammalian cell TSP N/A 65995-95-5 8.4.2 In vitro cytogenicity study in mammalian cells C 2001 abberation test line - CHO TFI/EFMA BioReliance AA43RC.331.BTL Wagner VO & TSP N/A 65995-95-6 8.4.1 Mutagenicity in bacteria Klug ML 2001 Bacterial reverse mutation assay Bacteria TFI/EFMA BioReliance 22949 4-week general toxicity and N/A 8.7.1 Screening for reproductive developmental reproductive / development toxicity TFI/EFMA TSP 65995-95-7 toxicity Dent MP 2002 screening test Rat HLS 22949

STPP 0 7758-29-4 9.1.3 Short -term toxicity to fish ? ? Short-term toxicity to fish Fish - bluegill P&G ? P&G internal ref: 15546 STPP 0 7758-29-4 8.1.1 Skin Irritation/ Corrosion In-vivo ? ? Skin irritation rabbit P&G ? 16927 STPP 0 7758-29-4 8.1.1 Skin Irritation/ Corrosion In-vivo ? ? Skin irritation rabbit P&G ? 10539 STPP 0 7758-29-4 8.1.1 Skin Irritation/ Corrosion In-vivo ? ? Skin irritation rabbit P&G ? 10120 STPP 0 7758-29-4 8.2.2 Eye Irritation/ Corrosion: In-vivo ? ? Eye irritation rabbits rabbit P&G ? 16769 STPP 0 7758-29-4 8.2.2 Eye Irritation/ Corrosion: In-vivo ? ? Eye irritation rabbits rabbit P&G ? 13185 STPP 0 7758-29-4 8.3 Skin sensitisation ? ? Clinical sensitisation Human P&G ? 5097 STPP 0 7758-29-4 8.3 Skin senstisation ? ? Clinical sensitisation Human P&G ? 5088 STPP 0 7758-29-4 8.3 Skin senstisation ? ? Clinical sensitisation Human P&G ? 5087 STPP 0 7758-29-4 8.3 Skin senstisation ? ? Clinical sensitisation Human P&G ? 5083 STPP 0 7758-29-4 8.3 Skin senstisation ? ? Clinical sensitisation Human P&G ? 5082 STPP 0 7758-29-4 8.3 Skin senstisation ? ? Clinical sensitisation Human P&G ? 5061 STPP 0 7758-29-4 8.3 Skin senstisation ? ? Clinical sensitisation Human P&G ? 2819 STPP 0 7758-29-4 8.3 Skin senstisation ? ? Clinical sensitisation Human P&G ? 1213 STPP 0 7758-29-4 8.3 Skin senstisation ? ? Clinical sensitisation Human P&G ? 409 STPP 0 7758-29-4 8.5.1 Acute Toxicity: Oral ? ? Acute toxicity rat P&G ? 18322 STPP 0 7758-29-4 8.5.1 Acute Toxicity: Oral ? ? Acute toxicity rat P&G ? 13611 STPP 0 7758-29-4 8.5.1 Acute Toxicity: Oral ? ? Acute toxicity mice P&G ? 36318 STPP 0 7758-29-4 8.5.1 Acute Toxicity: Oral ? ? Acute toxicity rat P&G ? 10842 STPP 0 7758-29-4 8.5.1 Acute Toxicity: Oral ? ? Acute toxicity mice P&G ? 3310 STPP 0 7758-29-4 8.6.1 short-term repeated dose, oral, 28-day ? ? Short-term repeated dose rat P&G ? 12207 STPP 0 7758-29-4 8.6.2 subchronic, 90-day, oral ? ? Subchronic toxicity rat P&G ? 103 STPP 0 7758-29-4 8.6.2 subchronic, 90-day, oral ? ? Subchronic toxicity rat P&G ? 102 STPP 0 7758-29-4 8.6.2 subchronic, 90-day, oral ? ? Subchronic toxicity rat P&G ? 101 8.6.1 Short-term Repeated Dose Toxicity: rat, Guinea pig, 0 Inhalation P&G STPP 7758-29-4 ? ? Short-term repeated dose Monkey ? 8689 STPP 0 7758-29-4 8.6.1 short-term repeated dose, oral, 28-day ? ? Short-term repeated dose Rat P&G ? 2813

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 18 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

RABBITS- New 0 P&G Zealand White STPP 7758-29-4 8.9.1 Chronic toxicity Dermal ? ? Carcinogenicity Male Rabbits ? 7336 MICE- Albino 0 COX ICR P&G STPP 7758-29-4 8.9.2 Carcinogenicity study- dermal ? ? Carcinogenicity Female Mice ? 6950 OECD 422: 28-day repeated dose and reprotoxicity OECD 422: 28-day repeated dose Biotoxtech Co., 13 NIER - Korea dipotassium phosphate 7758-11-4 study Shim YH 2005 and reprotoxicity study Rat Ltd. R05078 Choi S.A, Hong 48 NIER - Korea phosphoric acid Reverse mutation assay (AMES) E.K 2008 AMES test bacteria Medvill Co.Ltd G01-08085

STPP 0 7758-29-4 Water Solubility 2009 Water solubility N/A Harlan Labs

Sodium dihydrogenorthophosphate 2 7558-80-7 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0001

Sodium dihydrogenorthophosphate 2 7558-80-7 Melting point 2009 Melting point N/A Harlan Labs 2920/0001

Sodium dihydrogenorthophosphate 2 7558-80-7 8.3 Skin sensitisation 2009 Skin sensitisation Mouse Harlan Labs 2920/0003

Sodium dihydrogenorthophosphate 2 7558-80-7 8.5.1 Acute toxicity, oral 2009 Acute toxicity, oral Rat Harlan Labs 2920/0002

Sodium dihydrogenorthophosphate 2 7558-80-7 relative density 2010 relative density N/A Harlan Labs 2920/0098

Disodium hydrogenorthophosphate 3 7558-79-4 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0004

Disodium hydrogenorthophosphate 3 7558-79-4 Melting point 2009 Melting point N/A Harlan Labs 2920/0004

Disodium hydrogenorthophosphate 3 7558-79-4 8.5.1 Acute toxicity, oral 2009 Acute toxicity, oral Rat Harlan Labs 2920/0005 Trisodium orthophosphate 4 7601-54-9 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0006 Trisodium orthophosphate 4 7601-54-9 Melting point 2009 Melting point N/A Harlan Labs 2920/0006 Trisodium orthophosphate 4 7601-54-9 8.5.1 Acute toxicity, oral 2009 Acute toxicity, oral Rat Harlan Labs 2920/0007 monopotassium phosphate 12 7778-77-0 Boiling point 2009 Boiling point N/A Harlan Labs 2920/0008 monopotassium phosphate 12 7778-77-0 Vapour pressure 2009 Vapour pressure N/A Harlan Labs 2920/0008 monopotassium phosphate 12 7778-77-0 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0008 monopotassium phosphate 12 7778-77-0 relative density 2010 relative density N/A Harlan Labs 2920/0099 dipotassium phosphate 13 7758-11-4 Melting point 2009 Melting point N/A Harlan Labs 2920/0009 dipotassium phosphate 13 7758-11-4 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0009 dipotassium phosphate 13 7758-11-4 relative density 2010 relative density N/A Harlan Labs 2920/0100

13 soil Harlan Labs dipotassium phosphate 7758-11-4 Activated sludge respiration inhibition 2010 Activated sludge respiration inhibition microorganisms 2920/0121 dipotassium phosphate 13 7758-11-4 Acute oral toxicity 2010 acute oral toxicity rat Harlan Labs 2920/0140 tripotassium orthophosphate 14 7778-53-2 Water Solubility 2009 Water solubility N/A Harlan Labs 2920/0010 Calcium bis(dihydrogenorthophosphate) / 21 Harlan Labs monocalcium phosphate 7758-23-8 Melting point 2009 Melting point N/A 2920/0011 Calcium bis(dihydrogenorthophosphate) / 21 Harlan Labs monocalcium phosphate 7758-23-8 Water Solubility 2009 Water Solubility N/A 2920/0011

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 19 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

Calcium bis(dihydrogenorthophosphate) / 21 Harlan Labs monocalcium phosphate 7758-23-8 In vitro eye irritation 2009 Eye Irritation, in vitro in vitro tissues 2920/0094 Calcium bis(dihydrogenorthophosphate) / 21 Harlan labs monocalcium phosphate 7758-23-8 Eye irritation, in vivo 2010 eye irritation in vivo rabbit 2920/0127 Calcium bis(dihydrogenorthophosphate) / 21 Harlan labs monocalcium phosphate 7758-23-8 Acutr inhalation 2010 Acute toxicity: inhalation rat C92120

calcium hydrogenorthophosphate / 22 Harlan Labs Dicalcium phosphate 7757-93-9 Melting point 2009 Melting point N/A 2920/0012 calcium hydrogenorthophosphate / Dicalcium phosphate 22 7757-93-9 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0012 calcium hydrogenorthophosphate / 22 Harlan Labs Dicalcium phosphate 7757-93-9 8.2.2 Eye Irritation, in vitro 2009 Eye Irritation, in vitro in vitro tissues 2920/0013 Tricalcium bis(orthophosphate) 23 7758-87-4 Melting point 2009 Melting point N/A Harlan Labs 2920/0014 Tricalcium bis(orthophosphate) 23 7758-87-4 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0014 Tricalcium bis(orthophosphate) 23 7758-87-4 8.2.2 Eye Irritation, in vitro 2009 Eye Irritation, in vitro in vitro tissues Harlan Labs 2920/0017 Tricalcium bis(orthophosphate) 23 7758-87-4 8.1.1 Skin irritation, in vitro 2009 Skin irritation, in vitro in vitro tissues Harlan Labs 2920/0016 Tricalcium bis(orthophosphate) 23 7758-87-4 8.1.1 Skin corrosion, in vitro 2009 Skin corrosion, in vitro in vitro tissues Harlan Labs 2920/0068 Tricalcium bis(orthophosphate) 23 7758-87-4 8.5.1 Acute toxicity, oral 2009 Acute toxicity, oral Rat Harlan Labs 2920/0015 Tricalcium bis(orthophosphate) 23 7758-87-4 Eye irritation, in vivo 2010 eye irritation in vivo Rabbit Harlan Labs 2920/0128 tricalcium phosphate 24 12167-74-7 Water Solubility 2009 Water solubility N/A Harlan Labs 2920/0018 8.4.3 In vitro gene mutation study in mammalian tricalcium phosphate 24 12167-74-7 cells 2009 Mouse Lymphoma assay Murine cells Harlan Labs 2920/0079

Dimagnesium phosphate-3-hydrate 29 7757-86-0 Melting point 2009 Melting point N/A Harlan Labs 2920/0019

Dimagnesium phosphate-3-hydrate 29 7757-86-0 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0019

29 Harlan Labs Dimagnesium phosphate-3-hydrate 7757-86-0 8.2.2 Eye Irritation, in vitro 2009 Eye Irritation, in vitro in vitro tissues 2920/0091

Dimagnesium phosphate-3-hydrate 29 7757-86-0 8.1.1 Skin irritation, in vitro 2009 Skin irritation, in vitro in vitro tissues Harlan Labs 2920/0090

Dimagnesium phosphate-3-hydrate 29 7757-86-0 8.1.1 Skin corrosion, in vitro 2009 Skin corrosion, in vitro in vitro tissues Harlan Labs 2920/0089

Dimagnesium phosphate-3-hydrate 29 7757-86-0 8.5.1 Acute toxicity, oral 2009 Acute toxicity, oral Rat Harlan Labs 2920/0088

Trimagnesium phosphate-4-hydrate 30 7757-87-1 Melting point 2009 Melting point N/A Harlan Labs 2920/0020

Trimagnesium phosphate-4-hydrate 30 7757-87-1 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0020

salmonella 30 Harlan Labs typhimurium, Trimagnesium phosphate-4-hydrate 7757-87-1 8.4.1 In vitro gene mutation study in bacteria 2009AMES Escherichia coli 2920/0080 human Trimagnesium phosphate-4-hydrate 30 7757-87-1 8.4.2. In vitro cytogenicity assay 2009 Chromosomal abberation test lymphocytes Harlan Labs 2920/0081 8.4.3 In vitro gene mutation study in mammalian Trimagnesium phosphate-4-hydrate 30 7757-87-1 cells 2009 Muse Lymphoma assay Mouse cell line Harlan Labs 2920/0082

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 20 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested Magnesium bis(dihydrogenorthophosphate) 31 13092-66-5 Melting point 2009 Melting point N/A Harlan Labs 2920/0021 Magnesium bis(dihydrogenorthophosphate) 31 13092-66-5 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0021 iron orthophosphate 27 10045-86-0 Melting point 2009 Melting point N/A Harlan Labs 2920/0022 iron orthophosphate 27 10045-86-0 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0022

Trimanganese bis(orthophosphate) 33 14154-09-7 Melting point 2009 Melting point N/A Harlan Labs 2920/0023

Trimanganese bis(orthophosphate) 33 14154-09-7 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0023 Manganese bis(dihydrogen phosphate) 34 18718-07-5 Melting point 2009 Melting point N/A Harlan Labs 2920/0024 Manganese bis(dihydrogen phosphate) 34 18718-07-5 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0024

Dimanganese phosphate-2-hydrate 35 51349-94-1 Melting point 2009 Melting point N/A Harlan Labs 2920/0025

Dimanganese phosphate-2-hydrate 35 51349-94-1 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0025 Tricopper bis(orthophosphate) 36 7798-23-4 Melting point 2009 Melting point N/A Harlan Labs 2920/0026 Tricopper bis(orthophosphate) 36 7798-23-4 Water Solubility 2009 Water solubility N/A Harlan Labs 2920/0078 Dicopper hydroxide phosphate 38 12158-74-6 Melting point 2009 Melting point N/A Harlan Labs 2920/0027 Dicopper hydroxide phosphate 38 12158-74-6 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0027 Boron orthophosphate 44 13308-51-5 Melting point 2009 Melting point N/A Harlan Labs 2920/0028 Boron orthophosphate 44 13308-51-5 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0028

Aluminium tris dihydrogenphosphate 39 13530-50-2 Melting point 2009 Melting point N/A Harlan Labs 2920/0029

Aluminium tris dihydrogenphosphate 39 13530-50-2 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0029

Aluminium tris dihydrogenphosphate 39 13530-50-2 Relative density 2010 Relative density N/A Harlan Labs 2920/0103

Aluminium tris dihydrogenphosphate 39 13530-50-2 Acute inhalation toxicity 2010 Acute toxicity: inhalation rat Harlan Labs C89971 Aluminium orthophosphate 40 7784-30-7 Melting point 2009 Melting point N/A Harlan Labs 2920/0030 Aluminium orthophosphate 40 7784-30-7 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0030 Aluminium orthophosphate 40 7784-30-7 8.2.2 Eye Irritation, in vitro 2009 Eye Irritation, in vitro in vitro tissues Harlan Labs 2920/0033 Aluminium orthophosphate 40 7784-30-7 8.2.2 Eye Irritation, in vivo 2009 Eye Irritation, in vivo rabbit Harlan Labs 2920/0135 Aluminium orthophosphate 40 7784-30-7 8.1.1 Skin irritation, in vitro 2009 Skin irritation, in vitro in vitro tissues Harlan Labs 2920/0032

salmonella 40 Harlan Labs typhimurium, Aluminium orthophosphate 7784-30-7 8.4.1 In vitro gene mutation study in bacteria 2009AMES Escherichia coli 2920/0083 human Aluminium orthophosphate 40 7784-30-7 8.4.2. In vitro cytogenicity assay 2009 Chromosomal abberation test lymphocytes Harlan Labs 2920/0084 8.4.3 In vitro gene mutation study in mammalian Aluminium orthophosphate 40 7784-30-7 cells 2009 Muse Lymphoma assay Mouse cell line Harlan Labs 2920/0085 Aluminium orthophosphate 40 7784-30-7 8.1.1 Skin corrosion, in vitro 2009 Skin corrosion, in vitro in vitro tissues Harlan Labs 2920/0069 Aluminium orthophosphate 40 7784-30-7 8.5.1 Acute toxicity, oral 2009 Acute toxicity, oral Rat Harlan Labs 2920/0031

40 soil Harlan Labs Aluminium orthophosphate 7784-30-7 Activated sludge respiration inhibition 2010 Activated sludge respiration inhibition microorganisms 2920/0115

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 21 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

sodium aluminium phosphate 1:3:8 43 7785-88-8 Melting point 2009 Melting point N/A Harlan Labs 2920/0034 sodium aluminium phosphate 1:3:8 43 7785-88-8 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0034 sodium aluminium phosphate 1:3:8 43 7785-88-8 Relative density 2010 Relative density N/A Harlan Labs 2920/ sodium aluminium phosphate 3:2:8 43 7785-88-8 Melting point 2009 Melting point N/A Harlan Labs 2920/0073 sodium aluminium phosphate 3:2:8 43 7785-88-8 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0073

Disodium dihydrogen pyrophosphate 5 7758-16-9 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0039

Disodium dihydrogen pyrophosphate 5 7758-16-9 Melting point 2009 Melting point N/A Harlan Labs 2920/0039

Disodium dihydrogen pyrophosphate 5 7758-16-9 8.3 Skin sensitisation 2009 Skin sensitisation Mouse Harlan Labs 2920/0040

Disodium dihydrogen pyrophosphate 5 7758-16-9 8.2.2 Eye irritation , in vitro 2009 Eye irritation, in vitro in vitro tissues Harlan Labs 2920/0096

Disodium dihydrogen pyrophosphate 5 7758-16-9 eye irritation, in vivo 2010 eye irritation, in vivo Rabbit Harlan Labs 2920/0126

Disodium dihydrogen pyrophosphate 5 7758-16-9 Relative density 2010 Relative density N/A Harlan Labs 2920/0105

Disodium dihydrogen pyrophosphate 5 7758-16-9 Acute dermal toxicity (OECD 402) Bradshaw J 2010 Acute dermal toxicity (OECD 402) rat Harland Lbs 2920/0141 Trisodium hydrogen diphosphate 6 14691-80-6 Melting point 2009 Melting point N/A Harlan Labs 2920/0041 Trisodium hydrogen diphosphate 6 14691-80-6 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0041 Trisodium hydrogen diphosphate 6 14691-80-6 8.2.2 Eye Irritation, in vitro 2009 8.2.2 Eye Irritation, in vitro N/A Harlan Labs Trisodium hydrogen diphosphate 6 14691-80-6 8.1.1 Skin irritation, in vitro 2009 8.1.1 Skin irritation, in vitro N/A Harlan Labs Trisodium hydrogen diphosphate 6 14691-80-6 8.5.1 Acute toxicity, oral 2009 8.5.1 Acute toxicity, oral Harlan Labs Trisodium hydrogen diphosphate 6 14691-80-6 OECD 431 In vitro skin corrosion study 2010 skin corrosion in vitro in vitro tissues Harlan Labs 2920/0150 tetrasodium pyrophosphate 7 7722-88-5 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0045 tetrasodium pyrophosphate 7 7722-88-5 8.5.1 Acute toxicity, oral 2009 8.5.1 Acute toxicity, oral rat Harlan Labs 2920/0046 tetrasodium pyrophosphate 7 7722-88-5 Eye irritation, in vitro - BCOP 2010 Eye irritation in vitro bovine eye Harlan Labs 2920/0130 tetrasodium pyrophosphate 7 7722-88-5 Relative density 2010 Relative density N/A Harlan Labs 2920/0106 tetrasodium pyrophosphate 7 7722-88-5 eye irritation, in vivo 2010 eye irritation, in vivo Rabbit Harlan Labs 41003232 tetrapotassium pyrophosphate 15 7320-34-5 Water Solubility 2009 Water solubility N/A Harlan Labs 2920/0047 tetrapotassium pyrophosphate 15 7320-34-5 Hydrolysis as a function of pH 2009 Hydrolysis as a function of pH N/A Harlan Labs 2920/0047 tetrapotassium pyrophosphate 15 7320-34-5 Relative density 2010 Relative density N/A Harlan Labs 2920/0107

calcium dihydrogenpyrophosphate 25 14866-19-4 Melting point 2009 Melting point N/A Harlan Labs 2920/0048

calcium dihydrogenpyrophosphate 25 14866-19-4 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0048 Dicalcium pyrophosphate 26 7790-76-3 Melting point 2009 Melting point N/A Harlan Labs 2920/0049 Dicalcium pyrophosphate 26 7790-76-3 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0049 Dicalcium pyrophosphate 26 7790-76-3 Skin corrosion - in vitro; screening 2011 skin corrosion in vitro N/A Harlan Labs 2920/0152 Tetrairon tris(pyrophosphate) 28 10058-44-3 Melting point 2009 Melting point N/A Harlan Labs 2920/0050 Tetrairon tris(pyrophosphate) 28 10058-44-3 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0050 copper (II)-pyrophosphate 37 10102-90-6 Melting point 2009 Melting point N/A Harlan Labs 2920/0051 copper (II)-pyrophosphate 37 10102-90-6 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0051 magnesium pyrophosphate 57 13446-24-7 Water Solubility 2009 Water solubility N/A Harlan Labs 2920/0093 magnesium pyrophosphate 57 13446-24-7 in vitro skin corrosion 2011 in vitro skin corrosion N/A Harlan Labs 2920/0154 Pentapotassium triphosphate 16 13845-36-8 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0053 Pentapotassium triphosphate 16 13845-36-8 Melting point 2009 Melting point N/A Harlan Labs 2920/0092 Pentapotassium triphosphate 16 13845-36-8 8.5.1 Acute toxicity, oral 2009 Acute toxicity, oral rat Harlan Labs 2920/0054

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 22 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

Pentapotassium triphosphate 16 13845-36-8 Relative density 2010 Relative density N/A Harlan Labs 2920/0108 Sodium potassium tripolyphosphate / pentapotassium pentasodium 46 Harlan Labs bis(triphosphate) 24315-83-1 Melting point 2009 Melting point N/A 2920/0055 Sodium potassium tripolyphosphate / pentapotassium pentasodium 46 Harlan Labs bis(triphosphate) 24315-83-1 Water Solubility 2009 Water solubility N/A 2920/0055 Sodium potassium tripolyphosphate / pentapotassium pentasodium 46 Harlan Labs bis(triphosphate) 24315-83-1 8.5.1 Acute toxicity, oral 2009 Acute toxicity, oral rat Sodium potassium tripolyphosphate / pentapotassium pentasodium 46 Harlan Labs bis(triphosphate) 24315-83-1 8.1.1 Skin irritation, in vitro 2009 Skin irritation, in vitro in vitro tissues Sodium potassium tripolyphosphate / pentapotassium pentasodium 46 Harlan Labs bis(triphosphate) 24315-83-1 8.1.1 Skin corrosion, in vitro 2009 Skin corrosion, in vitro in vitro tissues Sodium potassium tripolyphosphate / pentapotassium pentasodium 46 Harlan Labs bis(triphosphate) 24315-83-1 8.2.2 Eye Irritation, in vitro 2009 Eye Irritation, in vitro in vitro tissues Aluminium tripolyphosphate 41 13939-25-8 Melting point 2009 Melting point N/A Harlan Labs 2920/0059 Aluminium tripolyphosphate 41 13939-25-8 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0059 Trisodium trimetaphosphate 8 7785-84-4 Melting point 2009 Melting point N/A Harlan Labs 2920/0061 Trisodium trimetaphosphate 8 7785-84-4 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0061 Trisodium trimetaphosphate 8 7785-84-4 Hydrolysis as a function of pH 2009 Hydrolysis as a function of pH N/A Harlan Labs 2920/0061

Trisodium trimetaphosphate 8 7785-84-4 Oxidising properties expert statement 2009 Oxidising properties expert statement N/A Harlan Labs 2920/0061 Trisodium trimetaphosphate 8 7785-84-4 Explosivity expert statement 2009 Explosivity expert statement N/A Harlan Labs 2920/0061 Trisodium trimetaphosphate 8 7785-84-4 8.5.1 Acute oral toxicity 2009 Acute oral toxicity Rat Harlan Labs 2920/0076 Trisodium trimetaphosphate 8 7785-84-4 8.3 Skin sensitisation 2009 Skin sensitisation Mouse Harlan Labs 2920/0077 Trisodium trimetaphosphate 8 7785-84-4 Relative density 2010 relative density N/A Harlan Labs 2920/0109 Sodium metaphosphate 10 10124-56-8 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0062 Sodium metaphosphate 10 10124-56-8 Melting point 2009 Melting point N/A Harlan Labs 2920/0062 Sodium metaphosphate 10 10124-56-8 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0062 Sodium metaphosphate 10 10124-56-8 Hydrolysis as a function of pH 2009 Hydrolysis as a function of pH N/A Harlan Labs 2920/0062

Sodium metaphosphate 10 10124-56-8 Oxidising properties expert statement 2009 Oxidising properties expert statement N/A Harlan Labs 2920/0062 Sodium metaphosphate 10 10124-56-8 Explosivity expert statement 2009 Explosivity expert statement N/A Harlan Labs 2920/0062 Sodium metaphosphate 10 10124-56-8 8.3 Skin sensitisation 2009 Skin sensitisation Mouse Harlan Labs 2920/0063 Sodium metaphosphate 10 10124-56-8 8.5.1 Acute oral toxicity 2009 Acute oral toxicity Rat Harlan Labs 2920/0097 Sodium metaphosphate 10 10124-56-8 Relative density 2010 Relative density N/A Harlan Labs 2920/0110 Sodium metaphosphate 10 10124-56-8 Acute toxicity to rainbow trout 2010 Acute toxicity to rainbow trout fish Harlan Labs 2920/0112 Sodium metaphosphate 10 10124-56-8 Algal growth inhibition 2010 Algal growth inhibition algae Harlan Labs 2920/0113

10 soil Harlan Labs Sodium metaphosphate 10124-56-8 Activated sludge respiration inhibition 2010 Activated sludge respiration inhibition microorganisms 2920/0114 Disodium fluorophosphate 47 10163-15-2 Melting point 2009 Melting point N/A Harlan Labs 2920/0064 Disodium fluorophosphate 47 10163-15-2 Water Solubility 2009 Water Solubility N/A Harlan Labs 2920/0064 Disodium fluorophosphate 47 10163-15-2 Hydrolysis as a function of pH 2009 Hydrolysis as a function of pH N/A Harlan Labs 2920/0064

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 23 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

Disodium fluorophosphate 47 10163-15-2 Oxidising properties expert statement 2009 Oxidising properties expert statement N/A Harlan Labs 2920/0064 Disodium fluorophosphate 47 10163-15-2 Explosivity expert statement 2009 Explosivity expert statement N/A Harlan Labs 2920/0064 Disodium fluorophosphate 47 10163-15-2 8.3 Skin sensitisation 2009 Skin sensitisation Mouse Harlan Labs 2920/0065 Disodium fluorophosphate 47 10163-15-2 8.1.1 Skin corrosion in vitro 2009 Skin irritation in vitro in vitro tissues Harlan Labs 2920/0066 Disodium fluorophosphate 47 10163-15-2 8.1.1 Skin corrosion in vitro 2009 Skin corrosion in vitro in vitro tissues Harlan Labs 2920/0072 Disodium fluorophosphate 47 10163-15-2 8.2.2 Eye irritation in vitro 2009 Eye irritation in vitro in vitro tissues Harlan Labs 2920/0067

salmonella 47 Harlan Labs typhimurium, Disodium fluorophosphate 10163-15-2 8.4.1 In vitro gene mutation study in bacteria 2009 AMES Escherichia coli 2920/0086 8.4.3 In vitro gene mutation study in mammalian Disodium fluorophosphate 47 10163-15-2 cells 2009 Mouse Lymphoma assay Mouse cell line Harlan Labs 2920/0087 Disodium fluorophosphate 47 10163-15-2 7.4 Relative Density 2010 7.4 Relative Density N/A Harlan Labs 2920/0110 Disodium fluorophosphate 47 10163-15-2 Acute toxicity to rainbow trout 2010 Acute toxicity to rainbow trout fish Harlan Labs 2920/0116 Disodium fluorophosphate 47 10163-15-2 Acute toxicity to Daphnia magna 2010 Acute toxicity to Daphnia magna daphnia Harlan Labs 2920/0117 Disodium fluorophosphate 47 10163-15-2 Algal growth inhibition 2010 Algal growth inhibition algae Harlan Labs 2920/0118

47 soil Harlan Labs Disodium fluorophosphate 10163-15-2 Activated sludge respiration inhibitin 2010 Activated sludge respiration inhibitin microorganisms 2920/0119 Disodium fluorophosphate 47 10163-15-2 Soil adsorption coefficient 2010 Soil adsorption coefficient soil Harlan Labs 2920/0120 Disodium fluorophosphate 47 10163-15-2 OECD 422 - range finder 2010 OECD 422 - range finder rat Harlan Labs 2920/0122 Disodium fluorophosphate 47 10163-15-2 OECD 422 -FULL STUDY 2010 OECD 422 -FULL STUDY rat Harlan Labs 2920/0123 Disodium fluorophosphate 47 10163-15-2 Eye irritation, in vivo 2010 Eye irritation, in vivo rabbit Harlan Labs 2920/0129 Disodium fluorophosphate 47 10163-15-2 acute toxicity: inhalation 2010 Acute toxicity: inhalation rat Harlan Labs C89982 All substances Dissociation constant 2009 Dissociation constant N/A Harlan Labs 2920/0036

Group 1: orthophosphates Oxidising properties expert statement 2009 Oxidising properties expert statement N/A Harlan Labs 2920/0035 Group 1: orthophosphates Explosivity expert statement 2009 Explosivity expert statement N/A Harlan Labs 2920/0035 TBC -Group 2: diphosphates Hydrolysis as a function of pH 2009 Hydrolysis as a function of pH N/A Harlan Labs

Group 2: diphosphates Oxidising properties expert statement 2009 Oxidising properties expert statement N/A Harlan Labs 2920/0052 Group 2: diphosphates Explosivity expert statement 2009 Explosivity expert statement N/A Harlan Labs 2920/0052 TBC -Group 3: triphosphates Hydrolysis as a function of pH 2009 Hydrolysis as a function of pH N/A Harlan Labs

Group 2: triphosphates Oxidising properties expert statement 2009 Oxidising properties expert statement N/A Harlan Labs 2920/0060 Group 2: triphosphates Explosivity expert statement 2009 Explosivity expert statement N/A Harlan Labs 2920/0060 S.TYPHIMURIU phosphoric acid 48 Reverse mutation assay (AMES) 2010 AMES M AND E. COLI Harlan Labs 2920-0142 8.4.3 In vitro gene mutation study in mammalian 48 Harlan Labs phosphoric acid cells 2010 Mouse Lymphoma assay Mouse cell line 3045/0001

N/A Harlan Labs HiPeak - mixtue of MKP and DKP N/A 6.1.1. Short-term toxicity to fish Priestly S 2010 Short-term toxicity to fish fish Rotem Amfert 3113/0002 6.1.3 Short-term toxicity to N/A Harlan Labs HiPeak - mixtue of MKP and DKP N/A 6.1.3 Short-term toxicity to invertebrates Priestly S 2010 invertebrates Daphnia magna Rotem Amfert 3113/0003 6.1.5 Toxicity to aqautic algae and N/A Harlan Labs HiPeak - mixtue of MKP and DKP N/A 6.1.5 Toxicity to aqautic algae and cyanobacteria vryenhoef H 2010 cyanobacteria algae Rotem Amfert 3113/0004 Trisodium trimetaphosphate 8 7785-84-4 Acute toxicity to Daphnia magna Weber B 2010 Acute toxicity to Daphnia magna daphnia DSM Harlan Labs C60787 - DSM

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 03 July 2014 24 Source Study organism substance sub ID CAS Nr. Endpoint Authors Object Lab Study n° Year tested

Trisodium trimetaphosphate 8 7785-84-4 Algal growth inhibition Weber B 2010 Algal growth inhibition algae DSM Harlan Labs C60798 - DSM In vitro gene mutation in bacterial phosphoric acid 48 AMES Choi SA 2008 cells bacteria NIER Medvill Co.Ltd G01-08085 reaction mass of MCP and DCP 60 Melting point 2010 Melting point N/A TIMAB Harlan Labs 3178/0001 reaction mass of MCP and DCP 60 Relative density 2010 Relative density N/A TIMAB Harlan Labs 3178/0001 reaction mass of MCP and DCP 60 Water Solubility 2010 Water Solubility N/A TIMAB Harlan Labs 3178/0001 reaction mass of MCP and DCP 60 Acute toxicity: oral 2010 acute toxicity: oral rat TIMAB Harlan Labs 3178/0002 reaction mass of MCP and DCP 60 in vitro skin irritation 2010 in vitro skin irritation N/A TIMAB Harlan Labs 3178/0004 reaction mass of MCP and DCP 60 Ex vivo skin corrosion 2010 Ex vivo skin corrosion N/A TIMAB Harlan Labs 3178/0003 reaction mass of MCP and DCP 60 In vitro eye irritation 2010 In vitro eye irritation tissues TIMAB Harlan Labs 3178/0006 reaction mass of MCP and DCP 60 Acute eye irritation 2010 Acute eye irritation rabbit TIMAB Harlan Labs 3178/005 iron orthophosphate 27 10045-86-0 Relative density 2011 Relative density N/A Harlan Labs 41101362 Activated Sludge Respiration iron orthophosphate 27 10045-86-0 Activated Sludge Respiration Inhibition 2011 Inhibition STP organisms Harlan Labs 41101366 iron orthophosphate 27 10045-86-0 Acute inhalation toxicity 2011 Acute inhalation toxicity Rat Harlan Labs 41101363 iron orthophosphate 27 10045-86-0 Skin sensitisation 2011 Local lymph node assay Mouse Harlan Labs 41101364 Mouse Lymphoma Assay (gene mutation in Mouse Lymphoma Assay (gene iron orthophosphate 27 10045-86-0 mammalian cells) 2011 mutation in mammalian cells) Mouse cells Harlan Labs 41101365 iron orthophosphate 27 10045-86-0 Acute oral toxicity 2011 Acute oral toxicity rat Harlan Labs 41103492 iron orthophosphate 27 10045-86-0 in vitro skin corrosion 2011 in vitro skin corrosion tissues Harlan Labs 41103494 iron orthophosphate 27 10045-86-0 in vitro skin irritancy 2011 in vitro skin irritancy tissues Harlan Labs 41103493 iron orthophosphate 27 10045-86-0 in vitro eye irritancy 2011 in vitro eye irritancy tissues Harlan Labs 41103495 ex-vivo rabbit iron orthophosphate 27 10045-86-0 ex-vivo REET 2011 ex-vivo REET eye Harlan Labs 41103495 iron orthophosphate 27 10045-86-0 Acute eye 2011 Acute eye rabbit Harlan Labs 41103496 iron orthophosphate 27 10045-86-0 Agal growth inhibition 2011 Agal growth inhibition algae Harlan Labs 41103497 Diphosphric acid, sodium salt 5 7758-16-9 8.5.1 Acute toxicity, oral ? 2009 Acute oral toxicity Mouse P&G ? Internal ref: 36318

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

sodium tripolyphosphate the toxicity of synthetic detergents (STPP) 0 7758-29-4 Henderson C. et al 1959 and soaps to fish fish sewage and industrial wastes 31: 295-306

sodium tripolyphosphate Detergent phosphorus effect on (STPP) 0 7758-29-4 Maloney T E 1966 algae. algae Journal of water pollutant control fed.38.38-45

Effect of Sodium tripolyphosphate (STPP) on the embryonic sodium tripolyphosphate Sinha P. and Kanamadi developmental stages of Zebrafish (STPP) 0 7758-29-4 R.D. 2000 Brachydanio rerio fish Environment and ecology 18(4): 1007-1010 Studies on the occurrence and sodium tripolyphosphate Engelbrecht R S and degradation of condensed phosphate (STPP) 0 7758-29-4 Morgan J J 1959 in surface waters. water Sewage and industrial wastes.31. sodium tripolyphosphate Kinetic studies on the hydrolysis of (STPP) 0 7758-29-4 Zinder B. et al 1984 STPP in sterile solution water water res. 18: 509-512 de Madariaga B.M., Ramos M.J. and Tarazona J.V Risk Assessment on EU phosphate consumption, effects assessment is Green Plant Research Report GPR-CEEP-07-1- sodium tripolyphosphate based on validated field studies.- Expanded Final Report. (also Layman's (STPP) 0 7758-29-4 2007 CEFIC sector group study N/A Summary of Report) Inman M.P., Beattie J.K., Abiotic hydrolysis of the detergent sodium tripolyphosphate Jones D.R., and Baldwin builder tripolyphosphate by hydrous (STPP) 0 7758-29-4 D.S. 2001 manganese dioxide. water Wat. Res. 35,8:1987-1993 sodium tripolyphosphate Sodium Tri(poly)phosphate in the (STPP) 0 7758-29-4 Lyons JW 1964 Kaolinite Water System. Clays Journal of Colloid Science 19: 399-412 sodium tripolyphosphate effects of synthetic detergents on (STPP) 0 7758-29-4 Smith R.S. Et al 1956 water coagulation water j am wat wks ass 48: 55-69 sodium tripolyphosphate The hydrolysis of sodium (STPP) 0 7758-29-4 Sutton A.H 1973 triphosphate in cod and beef muscle. cod J. Fd Technol., 8: 185-195

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

De Jager H and Heyns A M sodium tripolyphosphate Kinetics of acid-catalysed hydrolysis (STPP) 0 1998 of a polyphosphate in water. N/A J.phys.chem.102.2838-2841. Hydrolysis of triphosphate from Halliwell DJ, Mckelvie ID, detergents in a rural waste water sodium tripolyphosphate 0 Hart BT, Dunhill RH system N/A Wat. Res. 35(2): 448-454 Kulaev AS and Vagabov Polyphosphate metabolism in micro- STPP, 0 7758-29-4 VM 1983 organisms. n/a Advances in Microbial Physiology, 24: 83-171 A study of the substrate specificity Heppel LA, Harkness DR and othe properties of the alkaline The Journal of Biological Chemistry, 237(3): STPP, 0 7758-29-4 and Hilmoe RJ 1962 phosphatase of Escherichia coli. E.coli 841-846 Polyphosphate glucokinase from The Journal of Biological Chemistry, 261(10): STPP, 0 7758-29-4 Pepin CA and Wood HG 1986 Propionibacterium shermanii bacteria 4476-4480

Hydrolytic and enzymatic breakdown of food grade condensed phosphates Dissertation Abstracts International B47(): STPP, 0 7758-29-4 Reddy BR 1987 in white shrimp (Penaeus Setiferus). shrimp 4716 effect of the chelating agent sodium sodium tripolyphosphate Adersen, O. Hagerstrand I., triphosphate on cadmium toxicity in (STPP) 0 7758-29-4 Nordberg G.F. 1982 mice mice environmental research 29, 54-61 sodium tripolyphosphate Environmental Health Perspectives. 54: 249- (STPP) 0 7758-29-4 Andersen O et al 1984 Chelation of cadmium review N/A 266 sodium tripolyphosphate Andersen, O., Nielsen, oral cadmium chloride intoxication in (STPP) 0 7758-29-4 J.B., Svendsen. P. 1988 mice: effects of chelation by STPP mice Toxicology, 52: 65-79 Regulation of Resting and IL-2 activated Human Cytotoxic Lymphocytes by Exogenous sodium tripolyphosphate Nucleotides: Role of IL-2 and Ecto- venous blood (STPP) 0 7758-29-4 Bajpai. A., Brahmi Z. 1993 ATPases human cellular immunology 148: 130-143 Mobilization of some metals in water sodium tripolyphosphate and animal tissues by NTA, EDTA sediments, (STPP) 0 7758-29-4 Barica J. et al 1973 and TPP crayfish, fish Water res. 7: 1791-1804 Akute orale toxizitat von natriumtripolyphosphate an Sodium tripolyphosphate mannlichen und weilichen beagle- (STPP) 0 7758-29-4 Clairiant Hoescht 1975 hunden dog

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Field evalution of fluorescent whitening agent and sodium sodium tripolyphosphate triphosphate as indictators of septic New Zealand journal of marine and freshwater (STPP) 0 7758-29-4 Close M et al 1989 tank contamination in domestic wells water Research:23.563-568 sodium tripolyphosphate Respiratory toxicity of enzyme Cynomologus Toxicology and applied pharmcology 45.471- (STPP) 0 7758-29-4 Coate W B et al 1978 detergent dust Monkeys 496. sodium tripolyphosphate The crystal structure of sodium (STPP) 0 7758-29-4 Corbridge D E C 1960 triphosphate, Na5P3O10 phase I. n/a Acta Cryst.13,263. The crystal structure of sodium sodium tripolyphosphate Davies D R and Corbridge tripolyphosphate, Na5P3O10 phase (STPP) 0 7758-29-4 D E C 1958 II. n/a Acta Cryst.11,315. sodium tripolyphosphate Dymon J J and King A J Structure studies of the two forms of (STPP) 0 7758-29-4 1951 sodium tripolyphosphate. n/a Acta Cryst.4.378

Effects of detergent formula chelating sodium tripolyphosphate agents on the metabolism and (STPP) 0 7758-29-4 Engstrom B et al 1978 toxicity of Cadmium in mice. mice Acta pharmacol et toxicol.43.387-397 Effects of chelating agents on oral sodium tripolyphosphate uptake and renal deposition and (STPP) 0 7758-29-4 Engstrom B. 1984 excretion of cadmium mice Environmental Health perspective 54: 219-232 Effects of chelating agents on oral sodium tripolyphosphate uptake and renal deposition and (STPP) 0 7758-29-4 Engstrom B. 1984 excretion of cadium. mice Environmental health perspectives.54.219-232.

Effects of detergent formula chelating sodium tripolyphosphate Engstrom B., Nordberg. agents on the metabolism toxicity of (STPP) 0 7758-29-4 G.F. 1978 cadmium in mice mice Acta pharmacol. Et toxicol. 43: 387-397 sodium tripolyphosphate FDA STPP authorisation (STPP) 0 7758-29-4 21.182.1810.pdf ? ? ? 21 CFR Ch 1. (4-1-02 Edition), 45 sodium tripolyphosphate ökologische und toxicologische Betrachtung. (STPP) 0 7758-29-4 Foroutan-Rad M 1981 ? Umwelt 3: 218-224

The solution properties of supersaturated sodium tripolyphosphate sodium triphosphate forms I and II. (STPP) 0 7758-29-4 Griffith EJ and Metcalf JS 1993 physiochemical properties n/a Phosphorus, Sulphur and Silicon. 76:175-178. sodium tripolyphosphate The Chemical and Physical Properties of (STPP) 0 7758-29-4 Griffiths EJ 1975 physiochemical properties n/a Condensed Phosphates, 173-200

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Study of sodium tripolyphosphate- Hsieh F.-M., Huang C., Lin crosslinked chitosan beads sodium tripolyphosphate T.-F., Chen Y.-M. and Lin entrapped with Pseudomonas putida (STPP) 0 7758-29-4 J.-C. 2008 for phenol degradation. N/A Process Biochemistry. 43:83-92 sodium tripolyphosphate Data book of chromosomal aberration test in (STPP) 0 13573-18-7 Ishidate M, Sofuni T. 1998 chromosom al aberration test in vitro In vitro vitro primary mutagenicity screening of sodium tripolyphosphate food additives currently used in hamster (STPP) 0 13573-18-7 Ishidate M. et al 1984 Japan fibroblasts Fd. Chem. Toxic. 22(8): 623-636 factors affecting sensitivity of sodium tripolyphosphate Staphylococcus aureus 196E to applied and environmental microbiology: 842- (STPP) 0 7758-29-4 Jen C.M.C, Shelef L.A. 1986 polyphosphates bacteria 846 sodium tripolyphosphate Manufacture of sodium triphosphates (STPP) 0 7558-29-4 King CS 1944 - patent n/a n/a K-Z A Compilation of Solubility Data from the sodium tripolyphosphate Solubilities Inorganic and Metal- Periodical Literature Volume II 4th Edition. (STPP) 0 7758-29-4 Linke et al 1965 Organic Compounds water American Chemical Society Modeling of Exposure to Carpet- Cleaning Chemicals Preceding sodium tripolyphosphate Irritant Induced Asthma in One Environmental Health Perspectives, 108(9): (STPP) 0 7758-29-4 Lynch RM 2000 Patient. Human 911-913 sodium tripolyphosphate (STPP) 0 7758-29-4 Matiuchices V.B et al 1984 toxicologic caracterization of STPP rodents Gigiena i Sanitariya 15: 97-101 description of the toxicometric parameters of sodium sodium tripolyphosphate tripolyphosphate in Saccharomyces Vestnik Leningradskogo Universiteta Biologiya (STPP) 0 7758-29-4 Matyushichev VB et al 1984 cerevisiae yeast 3: 97-101 possible mechanism behind the adjuvant action of phosphate sodium tripolyphosphate derivatives on rectal absorption of J. of pharmaceutical Science 73(11): 1523- (STPP) 0 7758-29-4 Nishihata T. et al 1984 Cefoxitin in Rats and Dogs dog and rats 1525 Rabbits, sodium tripolyphosphate Evaultion of modified methods for Guinea-pigs, Regulatory toxicology and (STPP) 0 7758-29-4 Nixon G A.et al 1990 determining skin irritation. humans pharmacology.12.127-136 sodium tripolyphosphate Nixon G.A., Tyson C.A. Interspecies comparisons of skin Toxicology and applied pharmacology 31: 481- (STPP) 0 7758-29-4 And Wertz W.C. 1975 Irritancy Rabbits 490 sodium tripolyphosphate Nixon G.A., Tyson C.A. Interspecies comparisons of skin Toxicology and applied pharmacology 31: 481- (STPP) 0 7758-29-4 And Wertz W.C. 1975 Irritancy guinea pigs 490

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium tripolyphosphate Nixon G.A., Tyson C.A. Interspecies comparisons of skin Toxicology and applied pharmacology 31: 481- (STPP) 0 7758-29-4 And Wertz W.C. 1975 Irritancy human 490 Determination of ortho-, pyro- and sodium tripolyphosphate tripolyphosphate by the use of a Journal unknown (Department of Chemistry, (STPP) 0 7758-29-4 Ohashi S and Takada S 1961 small column of ion-exchange resin N/A Kanazawa University), 34(10): 1516-1518 sodium tripolyphosphate The effect of tripolyphosphate and (STPP) 0 7758-29-4 Oshiba et al. 1979 phytate on mineral balance in rats Rats sikatsu eisei 23(6): 209 A thermal microscopic and X-ray sodium tripolyphosphate study of the system NaPO3- (STPP) 0 7758-29-4 Partiridge E P et al. 1941 Na4P2O7 n/a .Journal of American chemistry society.454 sodium tripolyphosphate Schaffer JR and Polyelectrolyte Builders as Detergent (STTP) 0 7758-29-4 Woodhams RT 1977 Phosphate Replacements N/A Ind Eng Chem Prod Res Dev, 16: 3-11

Solubility equilibria of sodium sulphate at temperatures from 150°C to 350°C. III. Effect of sodium sodium triphosphate 0 7758-29-4 Schroeder WC et al 1937 hydroxide and sodium phosphate. N/A J. Am. Chem. Soc. 59(10): 1783-1790 ) Hydrolytic degradation of sodium tripolyphosphate in concentrated sodium tripolyphosphate solutions and in presence of foreign (STPP) 0 Shen CY 1966 ions Ind Eng Chem Prod Res Dev 5: 97-100

The results of microbial mutation test sodium tripolyphosphate for forty-three industrial chemicals (STPP) 0 13573-18-7 Shimizu H. et al 1985 (salmonella and Escherichia coli) bacteria Jpn. J. Ind. Health 27: 400-419 Distinguishing human from animal sodium tripolyphosphate Sinton L.W., Finlay R.K faecal contamination in water: a New Zealand Journal of Marine and (STPP) 0 7758-29-4 and Hannah D.J 1998 review. water Freshwater Research, 32: 323-348 sodium tripolyphosphate Toxicology and Applied Pharmacology, 5: 176- (STPP) 0 7758-29-4 Synder et al 1963 Toxicologic Studi es on Brighteners. 18 sodium tripolyphosphate Soaps and Detergents and the (STPP) 0 7758-29-4 Taylor A. 1980 Environment. JAOCS, November 1980: 859A-861A sodium tripolyphosphate Phosphorus in Environmental Technology (STPP) 0 7758-29-4 Valsami-Jones E 2004 physiochemical properties n/a Principles and Applications . sodium tripolyphosphate Van Wazer jr and Structure and properties of the (STPP) 0 7758-29-4 Campanella D 1950 condensed phosphates III and IV substance itself J Amer Chem Soc 72: 647 - 663

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Toxicity of laundry detergent components to a freshwater sodium tripolyphosphate Warne M.J. And Schifko cladoceran and their contribution to Ecotoxicology and environment safety 44: 196- (STPP) 0 7758-29-4 A.D. 1999 detergent toxicity Crustaceans 206 Efficacy of soluble sodium sodium tripolyphosphate tripolyphosphate amendments for the (STPP) 0 7758-29-4 Wellman D.M. Et al 2007 in-situ mobilisation of uranium river sediment Environ. Chem. 4: 293-300 Toxicological evaluation of some sodium tripolyphosphate extraction solvents and certain other FAO Nutrition Meetings Report Series No. 48A. (STPP) 0 7758-29-4 WHO 1970 substances rat, rabbit WHO/FOOD ADD/70.39 change in size of casein micelles sodium tripolyphosphate caused by addition of cleaning agent (STPP) 0 7758-29-4 Wieczorek J. et al 1996 components casein Netherlands Milk and Dairy J. 50: 53-59 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents Rats J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents dogs J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents Rabbits J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents Rabbits J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents Rabbits J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents Monkey J am chem soc 49: 539-551

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents human J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents human J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents human J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents human J am chem soc 49: 539-551

Research into the toxicity and effects Amoeba and of polyphosphates on growth of rotifer and cultures of amoeba, rotifers, Amphibian sodium tripolyphosphate tadpoles, and on the succession of (Bufo bufo and institut fur Landwirtschaftliche Zoologie und (STPP) 0 13573-18-7 Wuembach et al 1966 organisms in cellulose decomposition Xenopus laevis) bienenkunde, Report 33 pages Zettlemoyer AC and sodium triphosphate 0 7758-29-4 Schnieder CH 1956 The hydration of sodium phosphate N/A . J. Am. Chem. Soc. 78(16): 3870-3871 Effects of Potassium Sorbate and OtherAntibotulinal Agents on Germination and Outgrowth of Seward RA, Diebel RH, Clostridium botulinum Type E Spores Applied and evironmental microbiology. 44(5): sodium tripolyphosphate 0 Lindsay RC 1982 in Microcultures bacteria 1212-1221 The Effect of Food Grade Steinhauer JE and Banwart Polyphosphates on the Microbial sodium tripolyphosphate 0 GJ 1963 Population of Chicken Meat bacteria Poultry Science. 43:618-625 Archiv fur experimentelle Pathologie und disodium orthophosphate 2 munzer DE 1898 ? ? Pharmakologie 41: 74-96

Mutagenic evaluation of compound. S. typhimuium, monosodium phosphate FDA 73-2, monosodium phosphate Saccharomyces (MSP) 2 7558-80-7 Brusick D 1975 anhydrous powdered, FCC grade cerevisiae Litton Bionetics Inc. NTIS PB245508

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Initial submission: Primary skin irritation of sodium monosodium phosphate Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- (MSP) 2 7558-80-7 FX 1972 rabbits Rabbits 1861) monosodium phosphate Enlargement of parathyroid glands (MSP) 2 13472-35-0 Fazekas, IG 1954 by simple acidic compounds rabbits J. Anim. Sci. 80:1690-1695 monosodium phosphate phosphate induced renal calcification (MSP) 2 7558-80-7 Hitchman A.J. et al 1979 in the rat rats can j physiol pharmac 57(1):92 monosodium phosphate Injury to guinea pigs that follows a (MSP) 2 7558-80-7 House WB and Hogan AG 1955 high intake of phosphates Guinea pigs The Journal nutrition. 55:507-518 Mac Kay E M and Oilver J Renal damage following the injection ? monosodium phosphate of a diet containing an excess of (MSP) 2 7558-80-7 1935 inorganic phosphates. Journal of experimental medicine.61 Postnatal development of progeny after 5-HT and/or 32P treatment of monosodium phosphate 2 7558-80-7 Manowska J and Mazur L 1986 mice on the first day of gestation. mice Acta Physiologica Hungarica. 67(4): 419-422 monosodium phosphate experimental phosphate nephritis in (MSP) 2 7558-80-7 McFarlane D. 1941 the rat Rats J pathol. Bacteriol. 52: 17 Study of the genotoxic potential of 48 monosodium phosphate inorganic derivatives with the SOS (MSP) 2 7558-80-7 Olivier P. and Marzin D. 1987 chromotest bacteria Mutation research, 189(): 263-269

Triple Super Phosphate,. Ivy RE, Sulivan TW, DAP, sodium Goldner WJ, Graff CR & availability and toxicity of fertiliser dihydrogenorthophosphate 2 7558-80-7 Peo FR 1972 phosphates in the rat rat Poultry Science association meeting monosodium phosphate The toxic effect of some phosphate (MSP) 2 13472-35-0 McMeniman N.P. 1973 supplements fed to sheep sheep Australian Veterinarian J. 49: 150-152 Inorganic phosphate as a negative monosodium phosphate conditioning factor in plant cell (MSP) 2 7558-80-7 Sakano K. et al 1995 culture plant cells plant science 107: 117-124 Effects of dietary energy and phosphorus content on blood N. F. Cymbaluk and G. I. chemistry and development of monosodium phosphate 2 7558-80-7 Christison 1989 growing horses horse J Anim Sci 1989. 67:951-958.

Phosphorus Partitioning During Early monosodium phosphate, Lactation in Dairy Cows Fed Diets dicalcium phosphate 2 7758-80-7 Knowlton KF and Herbin JH 2002 Varying in Phosphorus Content cows J. Dairy Sci. 85:1227–1236

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Effect of Dietary Phosphorus on Lopez H, Kanitz FD, Performance of Lactating Dairy Moreria VR, Wiltbank VR Cows: Milk Production and Cow monosodium phosphate 2 7558-80-7 and Satter LD 2004 Health cows J. Dairy Sci. 87:139–146 Lopez H, Kanitz FD, Reproductive Performance of Dairy Moreria VR, Wiltbank VR Cows Fed Two Concentrations of monosodium phosphate 2 7558-80-7 and Satter LD 2004 Phosphorus cows Journal of Dairy Science 87(1) 146-157 Matsuzaki H, Katsumata S, High-Phosphorus Diet Induces Uehara M, Suzuki K, Miwa Osteopontin Expression of Renal monosodium phosphate 2 7558-80-7 M 2007 tubules in Rats rats (mutant) J. Clin. Biochem. Nutr., 41, 179–183, Milk Production, Estimated Phosphorus Excretion,and Bone Wu Z, Satter LD, Characteristics of Dairy Cows Fed Blohowiak AJ, Stauffacher Different Amounts of Phosphorus for monosodium phosphate 2 7558-80-7 RH and Wilson JH 2001 Two or Three Years cowx J. Dairy Sci. 84:1738–1748

Utilization of Phosphorus in Lactating wu Z, Tallam S, Ishler VA Cows Fed Varying Amounts of monosodium phosphate 2 7558-80-7 and Archibald DD 2003 Phosphorus and Forage cow J. Dairy Sci. 86:3300–3308 Milk Production, Reproductive Performance, and Fecal Excretion of Phosphorus by Dairy Cows Fed monosodium phosphate 2 7558-80-7 Wu Z, Satter LD & Sojo R 2000 Three Amounts of Phosphorus cow J Dairy Sci 83:1028–1041 correlation between the in vitro Brandao J.C., Bohets H.L., cytotoxicity to cultured fathead fish cells monosodium phosphate Van De Vyver I.E., Dierickx minnow fish cells and fish lethality (fathead (MSP) 2 7558-80-7 P.J. 1992 datas for 50 chemicals minnow) Chemosphere 25(4):553-562 (558) The thymidine incorporation inhibiting screening system (TSS) to test carcinogenic substances (A monosodium phosphate Amlacher E. and Rudolph nuclear DNA synthesis suppressive (MSP) 2 7558-80-7 C. 1981 short term test) mice Arch. Geschwulst. Forch. 51(7): 605-610 Influence of NaF and Na2PO3F on monosodium phosphate chemically induced aberrations in (MSP) 2 7558-80-7 Burki et al 1975 mature sperm of drosophila Drosphilia mutat res, 31: 315-316 Ittner J., Dambacher M.A., Muff R., Rüegsegger P., Reduced parathyroid hormone monosodium phosphate Trechsel U., and Fischer response to peroral phosphate in (MSP) 2 7558-80-7 J.A. 1986 osteoporotic patients. human Mineral Electrolyte Metab. 12:199-203

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monosodium phosphate Karbe, K., und G. Jander Die Metaphosphate in KOLLOID- (MSP) 2 7558-80-7 1943 BEIHEFTE. Heft 1-4, p1-146 Heft 1-4, p1-146 Studies of hydroxy-aluminium phosphates obtained from pentahydroxy-dialuminum chloride monosodium phosphate 2 7558-80-7 Misheva E 1990 and monosodium phosphate N/A Arch. Pharm. 323: 447-451 Miyoshi K, Funahashi H, Development of rat one-cell embryos Okuda K and Niwa K in a chemically defined medium: monosodium phosphate effects of glucose, phosphate and rat (in vitro Journal of Reproduction and Fertility. 100:21- (MSP) 2 7558-80-7 1994 osmolarity. emvryo) 26 Rapidly labelled polyphosphates and monosodium phosphate metaphosphates in the Blue-Green (MSP) 2 7558-80-7 Niemeyer R. and Richter G. 1969 Alga Anacystis nidulans algae Arch. Mikrobiol 69: 54-59 anticariogenic effect in the rat of monosodium phosphate Stookey G.K. And Muhler cereals fortified with a soluble (MSP) 2 7558-80-7 J.C. 1965 phosphate Rats J. D. Res 45(3): 856-864 monosodium phosphate,calcium phosphate Handbook of poisoning: prevention, 2 7558-80-7 Unknown ? diagnosis and treatment. human Eleventh Edition. Lange Medical Publications. Specification for the identity and purity of food additives and their WHO IPCS INCHEM toxicological evaluation: Emulsifiers, identity purity food stabilizers, bleaching and maturing additives P-acid & agents. Who health organisation monosodium phosphate phosphates Tech report technical report series No281. guinea pig, (MSP) 2 7558-80-7 281 dated 1964 1964 rabbit, man WHO

Phosphate supplementation in young monosodium phosphate Whybro A, Jagger H, men: lack of effect on calcium European Journal of Clinical Nutrition. 52: 29- (MSP) 2 7558-80-7 Barker M & Eastell R 1998 homeostasis and bone turnover. Man 33 Ricerche farmicologiche sul fosfato monosodium phosphate 2 7558-80-7 Gajatto DS 1939 monosodico ? Arch Farmacol Sper. 68:87-98 Agboola HA, Cahill VR, The effects of a high monosodium sodium Conrad HR, Ockerman phosphate and alpha tocopherol dihydrogenorthophosphate HW, Pareent NA and supplemented milk replacer diet on (MSP) 2 7558-80-7 Plimpton RF 1988 veal muscle color and composition. cow Journal of animal science. 66:1676-1685.

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium Draper HH, Sie TL and Osteoporosis in Aging Rats Induced dihydrogenorthophosphate 2 7558-80-7 Bergan JG 1972 by High Phosphorus Diets RAT J Nutr. 102: 1133-1142

Effects of calcium and phosphorous levels and diethylstilbestrol on urinary calculi incidence and feedlot monosodium phosphate 2 7558-80-7 Emerick RJ & Embry LB 1964 performance of lambs Sheep J Anim Sci. 23:1079-1083.

Schryver H, Hintz H and Calcium Metabolism in Ponies Fed a monosodium phosphate 2 7558-80-7 Craig P 1971 High Phosphorus Diet ponies J. NUTRITION,101: 259-264. minimal eventually lethal dose intravenous na2hpo4 acid sodium disodium phosphate (DSP) 3 7558-79-4 Osser S 1933 phosphate Rabbits arch ital sci farmacol 2(5)478-494 Modifications de la phosphatemie provoquees par l'ingestion journaliere disodium phosphate (DSP) 3 7558-79-4 Corbiau L 1936 de phosphate bisodique dog CR Soc Biol. 122: 474-475

Salmonella Mutagenicity test results environmental mutagenesis supplement 1: 3- disodium phosphate (DSP) 3 7558-79-4 Haworth S. et al 1983 for 250 chemicals (see subst. 216) bacteria 142 Initial submission: Primary skin irritation of sodium Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- disodium phosphate (DSP) 3 7558-79-4 FX 1972 rabbits Rabbits 1861) Erichsen Jones JR A study of the relative toxicity of anions, with polycelis nigra as test disodium phosphate (DSP) 3 7558-79-4 1941 animals. polycelis nigra Journal of Experimental Biology. 18: 170-181. tsuchiya N, Matsushima S, Glomerular calcification induced by Takasu N, kypkawa Y and bolus injection with dibasic sodium torii M phosphate solution in Sprague- disodium phosphate (DSP) 3 7558-79-4 2004 Dawley rats. rat Toxicologic Pathology. 32:408-412 Tsuchiya N, Tprii M, Early events involving glomerular Naramara I and Matsui T calcification induced by dibasic disodium phosphate (DSP) 3 7558-79-4 2008 sodium phosphate solution in rats. rat J Toxicol Pathol. 21: 229-237 Toxicity of ammonia, nitrite Ion, Nitrate Ion and orthophosphate to mercenaria mercenaria and institut fur Landwirtschaftliche Zoologie und disodium phosphate (DSP) 3 7558-79-4 Epifanio C.E., Sma R.F. 1975 crassostrea virginica clam and oyster bienenkunde, Report 33 pages

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

High phosphorus intake depresses Schonewille JT, Klooster apparent magnesium absorption in J. Anim. Pysiol. a. Anim. Nutr. 71 (1994), 15- disodium phosphate (DSP) 3 7558-79-4 AT & Beynen AC 1993 pregnant heifers cow 21 Response of Rainbow Trout (Oncorhynchus mykiss) Growing from 50 to 200 g to Supplements of Dibasic Sodium Phosphate in a disodium phosphate 3 7558-79-4 Rodenhutscord M 1996 Semipurified Diet fish J. Nutr. 126: 324-331 Rabbit corneal irrigation as a model System for studies on the relative toxicity of bacterial products implicated in periodontal disease. The toxicity of neutralised ammonia disodium phosphate (DSP) 3 7558-79-4 Rizzo A.A. 1967 solutions Rabbits j. periodont 38: 491-499 disodium phosphate (DSP) 3 7558-79-4 Milani R 1946 Induction of mutations with Na3PO4 Drosphilia Drosophila Information Service. 20: 87 effects of sodium phosphates and calcium salts on the hormones disodium phosphate (DSP) 3 7558-79-4 Abelin. I. 1928 produced by the thyroid gland rats Biochem. Z. Bachrach L., Correa A., Iron poisoning: Complications of Levin R. and Grossman M. hypertonic phosphate lavage therapy. Brief clinical and laboratory disodium phosphate (DSP) 3 7558-79-4 1979 observations. The Journal of Pediatrics. 94,1:147-149 Scientia Genetica. Vol II. Milani R. Produzione di mutazioni letali in 1940- Drosophila melaongaster per mezzo disodium phosphate (DSP) 3 7558-79-4 Buzzati-traverso A 1946 di fosfato di sodio Drosphilia N/A Report of the scientific committee for food. 7th Series. Commission of the European communities. disodium phosphate (DSP) 3 7558-79-4 1978 N/A N/A N/aA disodium Influence of dietary calcium and hydrogenorthophosphate Sobel A, Wexler I, phosphorous upon action of vitamin (DSP) 3 7558-79-4 Petrovsky D and Kramer B 1938 D in experimental lead poisoning rat Proc Soc Exper Biol Med. 38: 435 disodium phosphate, zinc Action de quelques composes phosphide, sodium inorganiques du phosphore sur hypophosphite, calcium l'evolution du rachtisme experimental hypophosphite 3 7558-79-4 Lecoq R and Villius F 1932 du rat rat CR Soc Biol. 109:630-631

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commision related to treatment of poultry carcasses with chlorine dioxide, acidified sodium chlorite, trisodium phosphate and trisodium phosphate (TSP) 4 7601-54-9 EFSA 2005 peroxyacids N/A The EFSA Journal 297.1-28 Assesment of the possible effect of the four antimicrobial treatment substances on the emergence of trisodium phosphate (TSP) 4 7601-54-9 EFSA 2008 antimicrobial resistance N/A EFSA: Summary of opinion Opinion onf the Scientific Committee on veterinary measures relating to public health: the evaluation of antimicrobial treatments for poultry trisodium phosphate (TSP) 4 7601-54-9 European Commission 2003 carcasses N/A European Commission Environmental impact and effect on antimicrobial resistance of four Scientific Committee on substances used for the removal of Health and Environmental microbial surface contamination of trisodium phosphate (TSP) 4 7601-54-9 Risks (SCHER) 2008 poultry carcasses N/A European Commission Unknown author where applicable, Workplace environmental exposure mouse, rabbit, American Industrial Hygiene Association trisodium phosphate (TSP) 4 7601-54-9 1982 level guide: trisodium phosphate. rat Journal . 43():b51-b52

Can chemicals precipitate dermatitis trisodium phosphate (TSP) 4 7601-54-9 Snider 1993 herpetiformis human J Am Aced Dermatol 28(1): 111-112

Acute toxicity of inorganic fertilizers Aquaculture and Fisheries Management, 21: trisodium phosphate (TSP) 4 7601-54-9 Ufodike EBC et al 1990 to African catfish Clarias gariepinus catfish 181-185 Induction of mutation with Na3PO4 trisodium phosphate (TSP) 4 7601-54-9 Fraile A and Sang H 1950 and with Harmine Drosphilia Drosophilia Information Service. 24: 81.

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Reversion of bioluminescent bacteria (Mutatox) to their luminescent state upon exposure to organic compounds, munitions, and Biomedical and environmental sciences, 7: trisodium phosphate (TSP) 4 7601-54-9 Arfsten et al 1994 metal salts bacteria 144-149 effect of sodium hydroxide and trisodium phosphate on the viability mycobacteria trisodium phosphate (TSP) 4 7601-54-9 Bates J.H. 1967 of some unclassified mycobacteria tuberculosis health lab Sci 4(1):42-50 Buzzati-Traverso A Sull'effectto mutageno del fosfato di Ricerca Scientifica E Ricostruzione.17(9-10): trisodium phosphate (TSP) 4 7601-54-9 1947 sodio. ? 1383-1384 Influence of strain and trisodium Capita R, Alonso-Calleja C, phosphate concentration on growth Garcia-Fernandez MC and parameters of Listeria Bacteria: trisodium phosphate (TSP) 4 7601-54-9 Moreno B 2001 monocytogenes in vitro Listeria Letters in Applied Microbiology. 32: 428-432

Activity of trisodium phosphate compared with sodium hydroxide Capita R, Alonso-Calleja C, was solutions against Listeria Garcia-Fernandez MC and monocytogenes attached to chicken Bacteria: trisodium phosphate (TSP) 4 7601-54-9 Moreno B 2002 skin during refrigerated storage Listeria Food Microbiology . 19: 57-63 Capita R, Alsonso-Calleja Influence of Poultry Carcass Skin C, Rodriguez-Perez R, Sample site on the effectiveness of Moreno B and Garcia- trisodium phosphate against Listeria Listeria trisodium phosphate (TSP) 4 7601-54-9 Fernandez MC 2002 monocytogenes monoctogenes Journal of Food Protection. 65(5): 853-856

Capita R, Alsonso-Calleja C, Sierra Castrillo M, Garcia Arias MT, Moreno B Sensitivity of Listeria monocytogenes Listeria trisodium phosphate (TSP) 4 7601-54-9 and Garcia-Fernandez MC 2000 to trisodium fosfate in vitro monoctogenes Mapfre Medicina. 11(4): 264-273 Some of the higher hydrates of trisodium phosphate Na3PO4 and trisodium phosphate (TSP) 4 7601-54-9 Clark GL and Gross ST 1937 trisodium vanadate Na3VO4 N/A Z. Krist. 98:107-111 Comparison of pathogenic and spoilage bacterial levels on Del Rio E, Capita R, Prieto refrigerated poultry parts following trisodium phosphate (TSP) 4 7601-54-9 M & Alonso-Calleja C 2006 treatment with trisodium phosphate Bacteria food Microbiology. 23: 195-198 Antimicrobial effects of trisodium Dickson JS, Nettles Cutter phosphate against bacteria attached trisodium phosphate (TSP) 4 7601-54-9 CG, Siragusa GR 1994 to beef tissue Bacteria Journal of Food Protection. 57(11): 952-955

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Efficacy of chemical treatments against murine norovirus, feline trisodium phosphate (TSP) 4 7601-54-9 D'Souza DH & Su X ? calicivirus, and MS2 bacteriophage Viruses Foodborne pathogens and Disease. 1-7 Ingerson E. and Morey preparation and properties of some G.W. compounds in the system H2O- trisodium phosphate (TSP) 4 7601-54-9 1943 Na2O-P2O5 N/A Amer. Min. 28:448-455

Kim JW, Slavik MF, Pharr Reduction of Salmonella on post-chill MD, Raben DP, Lobsinger chicken carcasses by trisodium trisodium phosphate (TSP) 4 7601-54-9 CM and Tsai S 1993 phosphate (Na3PO4) treatment Salmonella Journal of food safety. 14(1): 9-17 Effect of trisodium phosphate on Listeria monocytogenes attached to rainbow trout (oncorhynchus mykiss) Mu D, Huang Y, Gates KW and shrimp (Penaeus SPP) during Bacteria: trisodium phosphate (TSP) 4 7601-54-9 and Wu W 1997 refrigerated storage Listeria Journal of Food Safety. 17(1): 37-46 Muus J Die H.ydrolysegeschwindigheit von trisodium phosphate (TSP) 4 7601-54-9 1932 Pyrolrhosphorsânre. n/a Physik Chem A, 159, 268-276

The effects of EDTA and trisodium phosphate, alone and in combination with nisin, on the growth of trisodium phosphate (TSP) 4 7601-54-9 Phillips CA & Duggan J 2001 Arcobacter butzleri in culture Bacteria Food Microbiology. 18:547-554 Slanvin MF, Kim J, Pharr Effect of trisodium phosphate on MD, Raben DP, Tsai S & Campylobacter attached to post-chill trisodium phosphate (TSP) 4 7601-54-9 Lobsinger CM 1994 chicken carcasses Bacteria Journal of Food Protection. 57(4): 324-326 Effect of trisodium phosphate on biofilm and planktonic cells of Campylobacter jejuni, Escherichia coli O157: H7, Listeria Somers EB, Schoeni JL, monocytogenes and Salmonella Bacteria: International Journal of Food Microbiology. 22: trisodium phosphate (TSP) 4 7601-54-9 Wong ACL 1994 typhimurium various 269-276 The system sodium oxide - trisodium phosphate (TSP) 4 7601-54-9 Wendrow B & Kobe KA 1952 phosphorus pentoxide - water n/a Ind Eng Chem. 4: 1439-1448 Effects of trisodium phosphate adaptation on changes in membrane lipid composition, verotoxin secretion, and acid resistance of Escherichia coli O157:H7 in International Journal of Food Microbiology. trisodium phosphate (TSP) 4 7601-54-9 Yuk H, Marshall DL 2006 simulated gastric fluid Bacteria 106: 39-44

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Effectiveness of trisodium phosphate for killing Salmonella montevideo on Bacteria: trisodium phosphate (TSP) 4 7601-54-9 Zhuang RY & Beuchat LR 1996 tomatoes Salmonella Letters in Applied Microbiology. 22: 97-100 Initial submission: Primary skin irritation of sodium sodium acid Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- pyrophosphate (SAPP) 5 7758-16-9 FX 1972 rabbits Rabbits 1861) Craig JM Histologic and histochemical changes in the kidneys of rats fed a sodium acid diet with an excess of inorganic pyrophosphate (SAPP) 5 7758-16-9 1957 phosphate. rat Am J Pathol. 33: Separate and joint toxicity to rainbow sodium acid Sprague J.B. And Logan trout of substances used in drilling pyrophosphate (SAPP) 5 7758-16-9 W.J. 1979 fluids for oil exploration fish Environ. Pollut 79 :269-280 ABSTRACT: In vivo mutagenesis sodium acid investigations of four GRAS pyrophosphate (SAPP) 5 7758-16-9 Jorgenson T.A. Et al 1978 chemicals Rats Mutation research, 53: 205 Gao RC et al Purification and characterization of sodium acid pyrophosphatase from bighead carp pyrophosphate (SAPP) 5 7758-16-9 2006 (Aristichthys nobilis). Fish LWT 41: 254-261 sodium acid Lambert S M, Watters J I The complexes of pyrophosphate ion pyrophosphate (SAPP) 5 7758-16-9 1957 with alkali metal ions. N/A J Am Chem Soc 79: 4262 - 4265. Inhibition of Clostridium botulinum 52A Toxicity and Protease Activity by sodium acid Wagner M.K. And Busta Sodium Acid Pyrophosphate in applied and environmental microbiology July: pyrophosphate (SAPP) 5 7758-16-9 F.F. 1985 Media Systems bacteria 16-20 Zhu MJ et al Effect of Maternal Nutrient Restriction sodium acid in Sheep on the Development of pyrophosphate (SAPP) 5 7758-16-9 2004 Fetal Skeletal Muscle. Sheep Effects of Selected Commercial Marcy JA, Kraft AA, Phosphate Products on the Natural Hotchkiss DK, Molins RA, Bacterial Flora of a Cooked Meat Olson DG, Walker HW and System JOURNAL OF FOOD SCIENCE. 53(2): 391- trisodium pyrophosphate 6 14691-80-6 Merkenich K 1988 bacteria 393 Trisodium monohydrogen Trisodium monohydrogen pyrophosphate 6 14691-80-6 Hubbard FE 1949 pyrophosphate and its hydrates N/A Ind Eng Chem 41(12): 2908-2911

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Teratologic evaluation of FDA 73-1 Tetrasoidum tetrasodium pyrophosphate, NTIS PB245534: Report No: FDABF-GRAS- pyrophosphate (TSPP) 7 7722-88-5 Bailey DE 1976 anhydrous in mice and rats. mice, Rats 353

Mutagenic evaluation of compound. S. typhimuium, Tetrasoidum FDA 73-1, tetrasodium Saccharomyces pyrophosphate (TSPP) 7 7722-88-5 Brusick D 1975 pyrophosphate cerevisiae Litton Bionetics Inc. NTIS PB245489 Effects of added organic residues and calcium carbonate on Tetrasoidum Mnkeni P.N.S. And polyphosphate hydrolysis in four pyrophosphate (TSPP) 7 7722-88-5 MacKenzie A.F. 1987 Quebec soils soil Plant and soil 104: 163-167 Metal Ions Reverse the Inhibitory Effects of Selected Food-Grade Lee RM, Bartami PA, Olson Phosphates in Staphylococcus Journal of Food Protection. Vol. 57. No. 4. tetrasodium pyrophosphate 7 7722-88-5 DG & Wiliams FD 1994 aureus Bacteria Pages 284·288. Bidwell J.I., Jepson W.B. The interaction of kaolinite with and Toms G.L. polyphosphate and polyacrylate in Tetrasoidum aqueous solutions - some preliminary pyrophosphate (TSPP) 7 7722-88-5 1970 results. N/A Clay Minerals. 8: 445-459 Tetrasoidum Bonneman-Bémia P. Contribution a l'étude des acides pyrophosphate (TSPP) 7 7722-88-5 1941 phosphoriques condensés. N/A Ann. Chim. 16:395-477 The crystal structure of sodium tetrasodium pyrophosphate MacArthur DM and Beevers pyrophosphate decahydrate, (decahydrate) 7 7758-16-9 CA 1957 Na4P2O7.10H2O N/A Acta Cryst. 10, 428-432 tetrasodium pyrophosphate Rao RVGS and Unit cell and space group of sodium (decahydrate) 7 7758-16-9 Nampoothiri NS 1955 pyrophosphate N/A Acta cryst. 8:850

Tetrasoidum Biochemical studies in effects of Journal of Biological Chemistry: 242(10): 2375- pyrophosphate (TSPP) 7 7722-88-5 Tono H and Kornberg A 1967 phosphates in bacterial sporulation. Bacteria 2382 The effect of sodium trimetaphosphate as a chewing gum sodium trimetaphosphate additive on caries increment in (STMP) 8 7785-84-4 Finn SB et al 1978 children human j am den assoc 96: 651-655 Longitudinal Study of Cariostatic Effects of Sodium Trimetaphosphate and Sodium Fluoride When Fed sodium trimetaphosphate Separately and Together in Diets of (STMP) 8 7785-84-4 Navia J.M. And Harris R.S. 1969 Rats Rats J. Dent. Res. 48(2): 183-191

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Cariostatic effects of sodium trimetaphosphate when fed to rats sodium trimetaphosphate Navia J.M., Lopez H. And during different stages of tooth (STMP) 8 7785-84-4 Harris R.S. 1968 development Rats Archs oral Biol 13: 779-786 Initial submission: Primary skin irritation of sodium sodium trimetaphosphate Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- (STMP) 8 7785-84-4 FX 1972 rabbits Rabbits 1861) sodium trimetaphosphate Busman L.M. And Hydrolysis of trimetaphosphate in (STMP) 8 7785-84-4 Tabatabai M.A. 1985 soils soils soil sci soc amer proc 49: 630-636 sodium trimetaphosphate Katchman BJ and Smith Diffusion of synthetic and natural Archives of Biochemistry and Biophysics. 75: (STMP) 8 7785-84-4 HE 1958 polyphosphates. n/a 396-402. sodium trimetaphosphate Lieberman I Inorganic triphosphate synthesis by (STMP) 8 7785-84-4 1956 muscle adenylate kinase. n/a J biol chem. 219: 307-317 sodium hexametaphosphate 9 68915-31-1 Abelles. N 1927 toxicity of the (see substance) rats Biochem Z., 163():226

Further observations on the effects of polysodium the oral administration of polysodium metaphosphate PSMP 9 10124-56-8 Anderson C.K. Et al 1961 metaphosphate in the rat Rats Br. J. urol. 33: 135-140 Long-chain polyphosphates inhibit sodium polyphosphate growth of clostridium tyrobutyricum mixture (SPG 69%) 9 68915-31-1 Loessner M.J. Et al 1997 in processed cheese spreads bacteria J. Food protection 60(5): 493-498 Treatment of experimental acute uranium poisoning by chelating sodium polyphosphate 9 68915-31-1 Ortega A. et al 1989 agents mice Pharmacology and toxicology 64: 247-251 Long-chain polyphosphate causes cell lysis and inhibits Bacillus cereus Maier SK, Scherer S and spetum formation, which is Bacteria: Applied and environemtal microbiology. 65(9): sodium polyphosphate 9 68915-31-1 Loessner MJ 1999 dependant on divalent cations. Bacillus cereus 3942-3949 Growth Inhibition of Listeria monocytogenes by Sodium Zaika LL, Scullen J and Polyphosphate as Affected by sodium polyphosphate 9 68915-31-1 Fanelli JS 1997 Polyvalent Metal Ions bacteria Journal of food science 62(4): 867-870 sodium Teratologic evaluation of FDA 73-3 hexametaphosphate sodium hexametaphosphate in mice NTIS PB245535: Report No: FDABF-GRAS- (SHMP) 10 10124-56-8 Bailey DE 1974 and rats. mice, Rats 354

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium Mutagenic evaluation of compound. S. typhimuium, hexametaphosphate FDA 73-3, Sodium Saccharomyces (SHMP) 10 10124-56-8 Brusick D 1975 hexametaphosphate cerevisiae Litton Bionetics Inc. NTIS PB245486 Initial submission: Primary skin sodium irritation of sodium hexametaphosphate Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- (SHMP) 10 10124-56-8 FX 1972 rabbits Rabbits 1861) Kitahori Y, Konishi N, Cho sodium M, Yamamoto K, hexametaphosphate Nakagawa Y, Matsui E and Lack of carcinogenicity of sodium (SHMP) 10 10124-56-8 Hiasa Y 1998 metaphosphate in Fischer 344 rats. rat J Toxicol Pathol. 11:41-47 sodium Influence of sodium hexametaphosphate hexametaphosphate on selected (SHMP) 10 10124-56-8 Post F.J et al 1963 bacteria bacteria appl. Microbiology 11(5): 430-435 Influence of Hexametaphosphate on sodium Matsuoka A, Tsutsumi M & Staphylococcus aureus Cytoplasmic hexametaphosphate 10 10125-56-8 Wantanbe T 1997 Membrane Bacteria J. Food Hyg. Soc. Japan. 38(6): 441-445 Inhibitory Effect of sodium Matsuoka A, Tsutsumi M & Hexametaphosphate on the Growth hexametaphosphate 10 10125-56-8 Wantanbe T 1995 of Staphylococcus aureus Bacteria J. Food Hyg. Soc. Japan. 36(5): 588-594 sodium hexametaphosphate Physical properties of sodium (SHMP) 10 10124-56-8 Thomson RT 1935 hexametaphosphate. n/a Analyst, 61:320-323 sodium Baluyot E S., and Hartford Comparsion of polyphosphates hexametaphosphate C U analysis by ion chromatography and (SHMP) 10 10124-56-8 1996 modified end-griup titration n/a Journal of chromatography A.739.717-222. sodium The preparation and properties of hexametaphosphate tetra-, penta-, hexa-, hepta- and Journal of the American chemical society. (SHMP) 10 10124-56-8 Griffith EJ 1967 octaphosphates. 89(12): 2884 – 2890 sodium K. K. Jones hexametaphosphate The Physiology of Sodium American Water Works Association, p1471- (SHMP) 10 10124-56-8 1940 Hexametaphosphate. ? 1483 Stover FS et al Polyphosphate separations and chain sodium length characterization using hexametaphosphate minibore ion chromatography with (SHMP) 10 10124-56-8 1994 conductivity detection. n/a Journal of Chromatography A, 688: 89-95

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Repressible acid phosphomonoesterase and sodium consitutive pyrophosphatase of hexametaphosphate 10 10124-56-8 Weimberg R & Orton W L 1963 saccharomyces mellis n/a J. Bacteriol. 86:805-813

The mechanism of the hydrolysis of condensed phosphates. II. The sodium metaphosphate Watanabe M, Sato S and mechanism of the degradation of Bulletin of the Chemical Society of Japan insoluble (IMP) 11 10361-03-2 Saito H 1975 long-chain polyphosphates N/A 48(3): 896-898 sodium metaphosphate MZUZA8 Meditsinskii. Zhurnal MZUZA8 Meditsinskii. Zhurnal Uzbekistana. 8: insoluble (IMP) 11 10361-03-2 Axmedkahob D.K.A and Xalnaev1973 O.S.Uzbekistana. 8: 90 - 93 ? 90 - 93 Initial submission: Primary skin irritation of sodium sodium metaphosphate Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- insoluble (IMP) 11 10361-03-2 FX 1972 rabbits Rabbits 1861)

Bone formation in normal and sodium metaphosphate vitamin D-treated rachitie rats during insoluble (IMP) 11 10361-03-2 Irving J.T., Schibler D., and Fleisch1966 H.the administration of polyphosphates. rat Proc. Soc. Exp. Biol. Med. 123:332-335 Katchman BJ and Van sodium metaphosphate Wazar JR The "soluble" and "insoluble" insoluble (IMP) 11 10361-03-2 1954 polyphosphates of yeast. yeast Biochi biophys Acta. 14: 445-446 On the occurance of inorganic sodium metaphosphate polyphosphate hexokinase in some insoluble (IMP) 11 10361-03-2 Szymona M, Szymona O and1962 Kuleszamicroorganisms. S n/a Acta Microbiologica Polonica. 11:287-300 Structure and properties of the condensed phosphates. IV. Complex sodium metaphosphate Van Wazer J R, ion formation in polyphosphate insoluble (IMP) 11 10361-03-2 Campanella D A 1950 solutions. N/A J Amer. Chem. Soc. 72: 655 - 663 availability of phosphorus compounds as dietary phosphorus potassium sources for red sea bream dihydrogenorthophosphate 12 7778-77-0 Sakamoto S. amd Yone Y. 1979 (chrysophrys major) fish J. Fac. Agr. Kyushu Univ. 23, 177-184 Teratologic evaluation of FDA 73-65 monopotassium phosphate monopotassium phosphate in mice NTIS PB245521: Report No: FDABF-GRAS- (MKP) 12 7778-77-0 Bailey DE 1975 and rats. mice, Rats 340

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

NTIS Initial Submission: Toxicology Lab Report T-1680 Regarding Toxicity Studies Including Tripotassium Phosphate and Other Chemicals with Cover Letter Dated monopotassium phosphate 102729 Monopotassium Phosphate Stauffer Chemical Company, Western (MKP) 12 7778-77-0 Kamienski FX 1971 Acute Oral Screen Male Rats Research

Mutagenic evaluation of compound. S. typhimuium, monopotassium phosphate FDA 73-65, monopotassium Saccharomyces (MKP) 12 7778-77-0 Brusick D 1975 phosphate granular food grade cerevisiae Litton Bionetics Inc. NTIS PB245513 Molluscicidal activity of potassium to the zebra mussel, Dreissena monopotassium phosphate polymorphia; toxicity and mode of (MKP) 12 7778-77-0 Fischer W et al 1991 action Mussel Aquatic toxicology 20(4): 219-234 Dietary phosphorus requirements of Brown ML Jaramilloe F Jnr, juvienille sunshine bass, Morone monopotassium phosphate 12 7778-77-0 Gatlin DM III 1993 chrysops ♀ X M. saxatilis ♂ fish Aquaculture, 113 (1993) 355-363 Dougall DS, Curry Woods Dietary Phosphorus Requirement of L III, Douglass LW & Juvenile Striped Bass Morone The Journal of the world aquaculture society. monopotassium phosphate 12 7778-77-0 Soares JH 1996 saxatillis fish 27(1): 82-92 Béranger-Yvon A.et al. Quelques aspects de l'action des acides orthophorique, pyrophosphorique et adénosine- triphosphorique sur la croissance et monopotassium phosphate la photosynthèse de chlorella Revue de Cytologie et de Biologie Végétales. (MKP) 12 7778-77-0 1958 pyrenoidosa chick. algae XIX,2:433-452

Evidence that glucose is not always potassium dihydrogen Biggers JD and McGinnis an inhibitor of mouse preimplantation phosphate 12 7778-77-0 LK 2001 development in vitro mouse Human Reproduction. 16(1): 153-163 monopotassium phosphate X-ray analysis of the ferroelectric (MKP) 12 7778-77-0 Frazer BC and Pepinsky R 1953 transition in KH2PO4 N/A Acta Cryst. 6:273 Harris W W, et al. monopotassium phosphate Stimulation of Bone Formation in (MKP) 12 7778-77-0 1976 vivo by Phosphate Supplementation, dogs Calcif., Tiss. Res., 22, 85-98. Petters RM. et al. Glucose, glutamine and inorganic monopotassium phosphate phosphate in early development of Journal of Reproduction and Fertility. 89:269- (MKP) 12 7778-77-0 1990 the pig embryo in vitro. pig 275

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Dipotassium phosphate (DKP) 12 7778-77-0 Rana 1974 Ecophysiological studies on the uptakealgae of the pollutants, Indian copper, J Ecol zinc 1(1):and phosphate1-11 by certain algae Structure andthermal properties associated with some hydrogen monopotassium phosphate Ubbelohde AR & bonds in crystals. VII. Behaviour of Proceedings of the Royal Society 188 S: 358- (MKP) 12 7778-77-0 Woodward I 1947 KH2PO4 and KH2AsO4 on cooling n/a 372 XXVI. A quantitative X-ray analysis of monopotassium phosphate the structure of potassium (MKP) 12 7778-77-0 West J 1930 dihydrogen phosphate (KH2PO4) n/a Zeitschrift Fur Kristallographie. 74:306-332 Initial submission: Primary skin irritation of sodium Dipotassium phosphate Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- (DKP) 13 7758--11-4 FX 1972 rabbits Rabbits 1861) Chu, SP The influence of the mineral composition of the medium on the growth of planktonic algae. Part II: The influence of the concentration of Dipotassium phosphate inorganic nitrogen and phosphate (DKP) 13 7758-11-4 1943 phosphorus. algae Journal of Ecology, 31(2):109-148.

Potassium Hydrogen Phopshate Dipotassium phosphate induced nephropathy in the dog. Part (DKP) 13 77 Schneider P. et al - Part I 1980 I. Pathogenesis of tubular atrophy dog Vet. Pathol. 17: 699-719 Potassium Hydrogen Phopshate Dipotassium phosphate induced nephropathy in the dog. Part (DKP) 13 7758-11-4 Schneider P. et al - Part II 1980 II. Glomerular alterations dog Vet. Pathol. 17: 720-737 Elam CJ, Schneider BH Experimetally produced urinary dipotassium phosphate 13 7758-11-4 and Ham WE 1956 canuli in sheep Sheep J Anim Sci 1956. 15:800-810. Contribution a l'étude du systéme Dipotassium phosphate Flatt R, Brunisholz G and quinaire. Ca++ - K+-H+-NO3- - PO4-- (DKP) 13 7758-11-4 Bourgeois J 1956 - -H2O N/A Helv Chim Acta. 39:841-53 Dietary calcium and phosphorus Dipotassium phosphate levels and the vitamin D requirement (DKP) 13 7758-11-4 Nowotarski JS and Bird HR 1943 of the Chick chicken Poultry Sci. 22:72-78 Dipotassium phosphate Le system binaire: eau phosphate (DKP) 13 7758-11-4 Selva L 1947 dipotassique n/a Bull. Soc. Chim. France: 261-264 tetrapotassium Pyrophosphate Hydrolysis in soil as pyrophosphate (TKPP) 15 7320-34-5 Racz G.J. And Savant N.K. 1972 influenced by flooding and fixation soil soil sci soc amer proc 36: 678-682

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Subchronic oral toxicity study of potassium phosphate as a tetrapotassium preliminary to long-term pyrophosphate (TKPP) 15 7320-34-5 Shimoji N. et al 1988 carcinogenicity studies in F344 rats Rats Bul. Institute Hygenic sciences 106: 66

Potassium pyrophosphate, polyphosphates and The biochemistry of Inorganic cyclophosphates 15 7320-34-5 Kulaev IS 2004 polyphosphates N/A 2nd edition John Wiley and Sons Ltd Vibrational spectra of hydrated acid potassium tripolyphosphate Lyutsko VA, Shashkova IL and intermediate potassium (KTPP) 16 13845-36-8 and Prodan EA 1982 tripolyphosphate N/A Source unknown experiments on the metabolic potassium metaphosphate behaviour of highly condensed (KMP) 17 7790-53-6 Gassner K. 1957 potassium metaphosphate Rats biochem Z., 328: 485-491 potassium metaphosphate the hydrolysis of condensated (KMP) 17 7790-53-6 Thilo E. and Wieker W. 1957 phosphates in aqueous solution water Z anorg allg chem 291: 164-185

monoammonium Brosheer JC and Anderson The system ammonia-phosphoric phosphate (MAP) 18 7722-76-1 JF 1946 acid-water at 75° N/A unknown, 68:902-904 The effects of fire control chemicals Fire retardant (Phos- on hatchability of northern bobwhite Chek)containing quail (Colinus virginianus) and red- Monoammonium winged blackbirds (Agelaius phosphate 18 7722-76-1 Buscemi DM 1998 phoniceus) Birds University of Virginia MS Thesis. The toxicity of banded Urea or Diammonium phosphate to corn as diammonium phosphate influenced by soil temperature, (DAP) 18 7722-76-1 Creamer FL and Fox RH 1980 moisture and pH SOIL Soil Sci Soc Am J. 44(2): 296 The effect upon hematopoeisis of variations in the dietary levels of monoammonium Calcium, Phosphorous, Iron and phosphate (MAP) 18 7722-76-1 Day HG and Stein HJ 1938 Vitamin D: Two figures. Rats The Journal of Nutrition 16(6): 525-540 monoammonium Polosin VA and phosphate (MAP) 18 7722-76-1 Shakhporonov MI 1947 ? N/A Zh Fiz Khim. 21:119-123 monoammonium Acute Ammonium Salt Poisoning in phosphate (MAP) 18 7722-76-1 Singer R.H. and McCarty R.T.1971 Sheep. sheep Am. J. Vet. Res., 32(8): 1229-1238

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Biochemical toxicity of fertiliser di- diammonium phosphate ammonium phosphate to fish Clarias (DAP) 18 7722-76-1 Singh R et al 1995 batrachus FISH Uttar Pradesh J Zool. 15(2): 144-148 monoammonium Tenzer L, Frazer BC, A neutral structure analysis of phosphate (MAP) 18 7722-76-1 Pepinsky R 1958 tetragonal NH4H2PO4 N/A Acta Cryst. 11:505

Phosphorus concentrations in blood, Williams SN, McDowell LR, milk, feces, bone and selected fluids Warnick AC, Wilkinson NS and tissues of growing heifers as Livestock Research fro Rural development. monoamminium phosphate 18 and Lawrence LA 1991 affected by dietary phosphorus cows 3(2) [no pg numbers]

Phos-chek (DAP + additives) Fire-Trol 931 Handbook of Acute Toxicity of United States Department of the Interior Fish (ammonium polyphosphate Johnson WW and Finley Chemicals to Fish and Aquatic Fish and and Wildlife Service / Resource publication + additives) 19 7783-28-0 MT 1980 Invertebrates. invertebrates 137. Palanichamcy S., Food consumption of Sarotherodon Arunachamy S and Mossambicus (Trewaves) exposed to diammonium phosphate Balasubramanian M P sublethal concentration of (DAP) 19 7783-28-0 1985 diammonium phosphate fish ? Toxicty of Diammonium Phosphate diammonium phosphate Singh HR, Anoop K, to the Hillstream Minor Carp Barilus (DAP) 19 7783-28-0 Dobriyal and Pokhriyal RC 1985 Bendelisis Fish Uttar Pradesh J Zool, 5(1): 89-93 Crystallographic properties of diammonium phosphate Smith JP, Lehr JR and diammonium phosphate, (DAP) 19 7783-28-0 Brown WE 1957 (NH4)2HPO4 N/A Acta Cryst. 10: 709 Stavanja MS, Curtin GM, Ayres PH, Bombick ER, Borgerding MF, Morgan WT, Garner CD, Pence DH and Swauger JE Safety assessment of diammonium diammonium phosphate phosphate and urea used in the Experimental and Toxicologic Pathology 59: (DAP) 19 7783-28-0 2008 manufacture of cigarettes. CHO cells 339-353. Lobster larvae diammonium phosphate Marine bioassays with lobster larvae and (DAP) 19 7783-38-0 Wood 1985 and gammarids Gammarids Can Tech Rep Fish Aquat Sci, 0: 351-372 Effect of DAP toxicity on diammonium phosphate haematology of catfish (DAP) 19 7783-28-0 Yadav HN and Akela BP 1997 Heteropneustes fossilis (Bloch). Fish Environment and Ecology 15(2): 455-459

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Effect of DAP toxicity on certain diammonium phosphate Yadav HN, Akela BP and haematological parameters of (DAP) 19 7783-28-0 Kumari A 1998 Heteropneustes fossilis (Bloch). Fish Environment and Ecology 16(2): 431-434 diammonium phosphate Oltjen RR, Waller GR, Ruminant studies with diammonium (DAP) 19 7783-28-0 Nelson AB and Tillman AD 1963 phosphate and urea Sheep J. Anim. Sci. 24:36-42

Adaptation to and platability of urea, diammonium phosphate Schaadt H, Johnson RR biuret and diammonium phosphate (DAP) 19 7783-28-0 and McClure KE 1966 as NPN sources for ruminants Sheep J. Anim. Sci. 23: 73-77 In vitro and in vivo comparisons of diammonium phosphate Johnson RR and McClure the utilization of urea, biuret and (DAP) 19 7783-28-0 KE 1964 diammonium phosphate by sheep. Sheep J. Anim. Sci. 23: 208-213 Evaluation of diammonium diammonium phosphate Russel EL, Hale WH and phosphate as a source of nitrogen for (DAP) 19 7783-28-0 Hubbert F 1962 ruminants Sheep J. Anim. Sci. 21: 523-226 diammonium phosphate as a source diammonium phosphate Cowman GL and Thomas of nitrogen and phosphorous for beef (DAP) 19 7783-28-0 O 1962 cattle Cows J. Anim. Sci. 21: 992 An evaluation of diammonium Lassiter CA, Brown LD and phosphate as a nitrogen source for diammonium phosphate 19 Keyser D 1962 ruminants cows Mich State University Quartly Bulletin. ammonium Effect of anti-flame treating agents polyphosphates 20 14728-39-3 Aoyama M. 1975 on the skin rats and rabbits Nagoya Med, 20(1): 11-19 Ammonium Polyphosphate as a Ammonium polyphosphate source of nitrogen and phosphorous Agricultural experimental station bulletin 497: 1- (APP) 20 68333-79-9 Bell et al 1986 in cattle rations catlle 15 Hydrolysis of Pyrophosphate in a Highly Calcareous Soil: A Solid-State ammonium polyphosphate 20 14728-39-3 McBeath et al 2006 Phosphorus-31 NMR Study soil soil sci soc amer proc, on line march 29 Ammonium polyphosphate Liquid ammonium polyphosphate as Transactions of the American Fisheries (APP) 20 68333-79-9 Metzger RJ 1980 a fish pond fertilizer FISH Society, 109: 563-570 Liquid ammonium Liquid ammonium polyphosphate as Transactions of the American Fisheries polyphosphate (APP) 20 68333-79-9 Metzger RJ and Boyd CE 1980 a fish pond fertiliser. Fish society. 109:563-570 Liquid ammonium Liquid ammonium polyphosphate as fish and Transactions of the American Fisheries polyphosphate 20 68333-79-9 Metzger RJ and Boyd CE 1980 a fish pond fertiliser. plankton society. 109:563-570

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested ammonium polyphosphate, reactions of ammonium ortho- and triammonium polyphosphate fertilizer in soil: III pyrophosphate 20 14728-39-3 Sample E.C. Et al 1979 effects of associated cations soil soil sci soc amer 43: 58-65 Hydrolysis of ammonium Venugopalan M.V. And polyphosphate in soils under aerobic ammonium polyphosphate 20 14728-39-3 Prasad R. 1989 and anaerobic conditions soils biol fertil soils 8: 325-327 Initial Submission: acute toxicity test battery for monocalcium phosphate monocalcium phosphate anhydrous with cover letter dated (MCP) 21 7758-23-8 Sorenson SS 1985 102392 Rat NTIS OTS0571950 Report No. T-12163 Initial Submission: acute toxicity test battery for monocalcium phosphate monocalcium phosphate anhydrous with cover letter dated (MCP) 21 7758-23-8 Sorenson SS 1985 102392 Rabbit NTIS OTS0571950 Report No. T-12163 Initial Submission: acute toxicity test battery for monocalcium phosphate monocalcium phosphate anhydrous with cover letter dated (MCP) 21 7758-23-8 Sorenson SS 1985 102392 Rabbit NTIS OTS0571950 Report No. T-12163 Initial Submission: acute toxicity test battery for monocalcium phosphate monocalcium phosphate anhydrous with cover letter dated (MCP) 21 7758-23-8 Sorenson SS 1985 102392 Rabbit NTIS OTS0571950 Report No. T-12163

S. typhimuium, monocalcium phosphate Mutagenic evaluation of compound. Saccharomyces (MCP) 21 7758-23-8 Brusick D 1975 FDA 71-81, monocalcium phosphate cerevisiae Litton Bionetics Inc. NTIS PB245509 Hydrolysis of primary calcium monocalcium phosphate phosphate in function of the (MCP) 21 7758-23-8 Guillaume M. 1963 temperature water Bull. Sco. Roy. Sci. Liege 32(5-6): 362-365 monocalcium phosphate phosphate induced renal calcification (MCP) 21 7758-23-8 Hitchman A.J. et al 1979 in the rat rats can j physiol pharmac 57(1):92 interaction of monocalcium monocalcium phosphate phosphate monohydrate with water (MCP). 1-hydrate 21 10031-30-8 Misra N.P. Et al 1981 solubility and hydrolysis soil fert news 26: 34-36 monocalcium phosphate the hydrolysis rate of monocalcium (MCP) 21 7758-23-8 Pozin M.E. Et al 1959 phosphate in aqueous solutions water j appl chem ussr 32: 736 monocalcium phosphate Sollmann T. Schettler O.H. studies of chronic toxicity in albino (MCP) 21 7758-23-8 And Wetzel N.C. 1921 rats IV Rats j pharm exp therap 17():197-225

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Application of phase rule to the monocalcium phosphate chemical behaviour of monocalcium (MCP) 21 7758-23-8 Brown WE and Lehr JR 1959 phosphate monohydrate in soils. N/A Soil Sci. Soc. Am. Proc. 23:7-11

Nature of reactions of monocalcium monocalcium phosphate Lindsay WL and phosphate monohydrate in soils: I. (MCP) 21 7758-23-8 Stephenson HF 1959 The solution that reacts with the soil. N/A ? Effect of calcium phosphate monocalcium phosphate Jones MR, Hardwick LL, supplementation on blood pressure (MCP) 21 7758-23-8 Clemens RA 1987 in the wistar rat. rat Nutrition Research, 7:779-785 dietary phosphorus requirements of juvienile haddock (Melanogrammus monocalcium phosphate 21 7758-23-8 Roy PK and Lall SP 2003 aeglefinus L.) fish Aquaculture 221 (2003) 451–468 Control of phosphorus homeostasis monocalcium phosphate. of Atlantic salmon (Salmo salar) in Monohydrate 21 7758-23-8 Vielma J and Lall SP 1998 fresh water. fish Fish Pysiology and biochemistry, 19 :83-93 In Russian, so the GTPZAB (1987) Phosphoric Acid russians :) calcium salt (2:) monohydrate. monocalcium phosphate RTECS Gigiena Truda I Labor Higiene and Occupational Diseases 31 (MCP) 21 7758-23-8 1987 Professional'nye Zabolevniya. N/A (12) 53. Comunicacion Corta Intoxicacian por monocalcium phosphate fosfato dicaclcico (CaHPO4) en (MCP) 21 7758-23-8 Alfonso et al 1988 terneros calf Rev Salud Anim, 10 : 261-262 Mineral metabolism of aging female rats fed various commercially monocalcium phosphate available calcium supplements or (MCP) 21 7758-23-8 Behling et al 1988 yoghurt rats Pharmaceutical Research, 5 (8): 501-505 The vapour pressures of saturation monocalcium phosphate solutions and solubilities in the (MCP) 21 7758-23-8 Belopolski et al 1940 system N/A Unknown monocalcium phosphate Investigations on the solubility of (hydrated and anhydrous), 21 7758-23-8 Bjerrum N 1949 calcium phosphates N/A Niels Bjerrum Selected Papers. 245-249 Calcium phosphate containing monocalcium phosphate precipitate and the carcinogenicity of (MCP) 21 7758-23-8 Cohen S.M. Et al 2000 sodium salts in rats rats Carcinogenesis 21(4): 783-792 monocalcium phosphate (MCP) 21 7758-23-8 Cohen SM 1998 Cell proliferation and carcinogenesis Cells drug metabolism reviews, 30(2): 339-357

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monocalcium phosphate Dissolution behaviour of carbonated drug development and industrial pharmacy, (MCP) 21 7758-23-8 Daabees N et al 1988 apatites in the presence of some ions 14(3): 1855-1875 Everson GE et al monocalcium phosphate Chemistry Set Chemicals: An (MCP) 21 7758-23-8 1988 Evaluation of Their Toxic Potential. N/A Vet Hum Toxicol 30(6): 589-592 Fleisch H and Russell RGG A Review of the Physiological and Pharmacological Effects of monocalcium phosphate Pyrophosphate and Diphosphonates (MCP) 21 7758-23-8 1972 on Bones and Teeth. N/A J Dent Res Supplement to No 2, 51:324-332 monocalcium phosphate Gigiena I Sanitaria, 52 (MCP) 21 7758-23-8 (12):87, 1987 1987 ? Gigiena I Sanitaria, 52 (12):87, 1987 Studies on the nutrition of salmoid monocalcium phosphate Knox D, Cowey CB and fish. The magnesium requirements of dihydrate (MCP) 21 7758-23-8 Adron JW 1981 rainbow trout (Salmo gairdneri) fish Br. J. Nutr:45 monocalcium phosphate Larson H W E Preparation and properties of mono-, (MCP) 21 7758-23-8 1935 di- and tricalcium phosphates. N/A Industrial and engineering chemistry.7 monocalcium phosphate Lehr JR, Brown WE and Chemical behaviour of monocalcium (MCP) 21 7758-23-8 Brown EH 1959 phosphate monohydrate in soils. Soil Sci. Soc. Am. Proc. 23: 3-12

The physiological response of peritoneal tissue to certain industrial Calcium phosphate dust 21 7758-23-8 Miller JW 1936 and pure mineral dusts guinea pig Public health reports. 51(49):1677-1688 Response of growing Pekin ducks to supplementation of monobasic monocalcium phosphate calcium phosphate to low (MCP) 21 7758-23-8 Rodehutscord M et al 2003 phosphorus diets duck Poult. Sci. 82(2):309-319. Comparative studies with three-week- old chickens, turkeys, ducks and quails on the response in phosphorus monocalcium phosphate utilization to a supplementation of (MCP) 21 7758-23-8 Rodehutscord M et al 2005 monobasic calcium phosphate turkey, duck Poult. Sci. 82(2):309-319. monocalcium phosphate the effects of salts on the dissolution (MCP) 21 7758-23-8 Taylor AW and Gurney EL 1965 of monocalcium phosphate Soil Sci Soc Am J. 29:151-153

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monocalcium phosphate Yakovleva, Efimova, dihydromoncalcium phosphate in the (MCP) 21 7758-23-8 Shafranskii 1979 x-ray therapy fo tumours Animal ? med radiol 24: 16-19 calcium phosphate [ in the system: Ca(OH)2-H3P)4- Ion association in calcium phosphate KCl-H2O ] 21 7758-23-8 Zhang J 1991 solutions at 37°C. N/A Journal of solution chemistry. 20:5 455-465 Characterization of acid-base disturbances and effects on calcium and phosphorus balances of dietary Fredeen AH, DePeters EJ fixed ions in pregnant or lactating monocalcium phosphate 21 7758-23-8 and Baldwin RL 1988 does goats J Anim Sci 1988. 66:159-173 A clinical test of addition of dicalcium phosphate (DCP) 22 7757-93-9 Averill H.M. And Bibby B.G. 1964 phosphates to the diet of children human J. D. Res suppl to num 6, 43: 1150-1155 effect on dental caries of a dentifrice containing stannous fluoride and dicalcium phosphate (DCP) 22 7757-93-9 Muhler J.C. 1957 dicalcium phosphate human J. D. Res. 36(3): 399-402 Anticariogenic effect of dicalcium dicalcium phosphate phosphate dihydrate chewing gum: dihydrate 22 7789-77-7 Richardson A.S. Et al 1972 result after two years human J Canad Dent Asso 6: Initial submission: Primary skin irritation of sodium Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- dicalcium phosphate (DCP) 22 7757-93-9 FX 1972 rabbits Rabbits 1861) Transformation of dibasic calcium phosphate dihydrate and octacalcium dibasic calcium phosphate phosphate in slightly acid and dihydrate 22 7789-77-7 Bell L.C. And Black C.A. 1970 alkaline soils soil soil sci soc amer proc 34: 583-587 Urea phosphate and monoammonium phosphate as dietary supplements for sheep fed diets Fishwick G and inadequate in phosphorous and dicalcium phosphate 22 231-826-1 Hemingway RG 1973 nitrogen Sheep J. agric. Sci. Cam. 81: 139-143 Energy and Phosphorus Status as Factors Affecting Postpartum Carstairs JA, Neitzel RR Performance dicalcium phosphate 22 7757-93-9 and Emery RS 1981 and Health of Dairy Cows cows Journal of Dairy Science. 64(1)

Cerosaletti PE, Fox DG and Phosphorus Reduction Through dicalcium phosphate 22 7757-93-9 Chase LE 2004 Precision Feeding of Dairy Cattle cows J. Dairy Sci. 87:2314–2323

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N. R. Combs, E. T. Calcium and phosphorus Kornegay, M. D. requirement of swine from weaning Lindemann and D. R. to market weight: I. Development of dicalcium phosphate 22 7757-93-9 Notter 1991 responseReliability curvesof Dietary for performanceCa and P Levels pig J Anim Sci 1991. 69:673-681. and Bone Mineral Content as dicalcium phosphate 22 7757-93-9 Crenshaw TD 1986 Predictors of Bone Mechanical pig J Nutr. 116:2155-2170 Effect of various calcium:phosphorus ratios at low and high dietary G. A. Reinhart and D. C. phosphorus for starter, grower and dicalcium phosphate 22 7757-93-9 Mahan 1986 finishing swine pig J. Anim. Sci. 1986.63:457-466 Health hazard evaluation/toxicity Dicalcium phosphate dust determination. Arco polymer (DCP) 22 7757-93-9 NTIS 1974 Solubilityincorporated and , solubilityMonaca, productPennsylvania of N/A N/A dicalcium phosphate dihydrate in dicalcium phosphate (DCP) 22 7757-93-9 Bennett AC and Adams F 1976 aqueous solutions and soil solutions. Soil Sci Soc Am J. 40(1): 39-42 The determination of retainable phosphorus, relative biological Dicalcium phosphate, availability, and relative biological Defluorinated phosphate value of phosphorus sources for 22 7757-93-9 Coon CN et al 2007 broilers chicken Poult. Sci. 86:857-868. Versuche zur ermittlung Domontovitch MK and loslichkeitsproducts von dicalcium phosphate (DCP) 22 7757-93-9 Sarubina OV 1925 dicalciumphosphat N/A Biochem Z. 163: 646-9 The instability constant and hydrogen ion dissociation of calcium hydrogen dicalcium phosphate (DCP) 22 7757-93-9 Greenwald I 1963 phosphate. N/A J Phys Chem. 67:2853-2854 Solubility of CaHPO4.2H2O in the Calcium system Ca(OH)2-H3PO4-H2O, at 5, Journal of Research of the National Bureau of hydrogenorthophosphate 15, 25, and 37.5°C. J. Res. Nat. Bur. standards. A. Physics and Chemistry. 74A(4): dihydrate (DCP) 22 7757-93-9 Gregory TM et al 1970 Stand – A. N/A 461-475. Inactivation of Transmissible Spongiform Encephalopathy agents during the manufacture of Dicalcium Hamster and dicalcium phosphate (DCP) 22 7757-93-9 Grobben AH et al 2006 phosphate from bone. mouse Veterinary Record, 158: 361-366 ABSTRACT: magnesium ammonium phosphate as a mineral supplement dicalcium phosphate (DCP) 22 7757-93-9 Hemingway R.G. Et al 1967 for growing lambs Nutrition society: 24

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

The effects of dietary minerals and Johnson RJ and electrolytes on the growth and dicalcium phosphate (DCP) 22 7757-93-9 Karunajeewa H 1985 physiology of the young chick. Chicken J. Nutr. 115: 1680 – 1690 Chemical and Physical Evaluations of Commercial Dicalcium dicalcium phosphate Phosphates as Sources of dihydrate (DCP) 22 757-93-9 Lima FR et al 1995 Phosphorous in Animal Nutrition. N/A Poultry Sci, 47: 1659-167 dicalcium phosphate, Miller MW and Joukovsky Availability of phosphorus from defluorinated phosphate 22 7757-93-9 VV 1953 various phosphate materials chicken Poultry Sci. 32:78-81 solubility of gypsum and dicalcium calcium phosphate phosphate dihydrate in the system dihydrate 22 7789-77-7 Moreno EC and Osborn G 1963 CaO-P2O5-SO3-H2O and in soils. Soil Sci soc Am J. 27:614-619 Dicalcium phosphate Moreno EC, Brown WE and solubility of dicalcium phosphate dihydrate 22 7789-77-7 Osborn G 1960 dihydrate in aqueous systems. Soil sci Soc Am J. 24:94-98 Sur la solubilité du phosphate bicalcique dans l’eau pure. On the solubility of dicalcium Dicalcium phosphate phospahte in pure water. (DCP) 22 7757-93-9 Rindell MA 1902 N/A Comptes Rendus de l’Acad. Sci. 134:112-114. Hydrolysis of dicalcium phosphate dicalcium phosphate dihydrate in the presence or absence dihydrate 22 7789-77-7 Tung M.S. Et al 1985 of calcium fluoride water J. Dent. Res. 64(1): 2-5 Toxicity of excess dicalcium Wallner-Pendleton E.A. Et Phosphate in the Diet of Turkey dicalcium phosphate (DCP) 22 7757-93-9 al 1989 Poults turkey avian diseases 33: 375-378 Wilcox RA, Carlson CW, The availability of phosphorus from Kohlmeyer WM and different sources for poults fed dicalcium phosphate 22 7757-93-9 Gastler GF 1955 practical-type diets turkey Poultry Science. 34: 1017-1023 Unexpected pH dependence of dicalcium phosphate dissolution kinetics of dicalcium dihydrate 22 7789-77-7 Zhang J 1994 phosphate dihydrate. J. Phys. Chem, 98 Dissolution deceleration of calcium phosphate crystals at constant dicalcium phosphate (DCP) 22 7757-93-9 Zhang J 1992 undersaturation N/A Journal of crystal growth. 123: 59-68 dicalcium phosphate Interpretation of dissolution kinetics (DCP) 22 7757-93-9 Zhang J 1992 of dicalcium phosphate dihydrate. N/A Journal of Crystal Growth. 125. 251-269 Effect of Dietary Phosphorus on dicalcium phosphate Anderson GH and Draper Calcium Metabolism in Intact and monohydrate 22 HH 1972 Parathyroidectomized Adult Rats rat the Journal of nutrition

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

The Role of Calcium and Phosphorus Edwards HM and Veltmann in the Etiology of Tibial dicalcium phosphate 22 7757-93-9 JR 1983 Dyschondroplasia in Young Chicks chicken J Nutr. 113:1568-1575

EFFECTS OF DIETARY CALCIUM, PHOSPHORUS, CALCIUM: PHOSPHORUS RATIO AND VITAMIN K ON PERFORMANCE, D. D. Hall, G. L. Cromwell BONE STRENGTH AND BLOOD dicalcium phosphate 22 7757-93-9 and T. S. Stahly 1991 CLOTTING STATUS OF PIGS pig J Anim Sci 1991. 69:646-655. Effects of zeranol and two dietary levels of calcium and phosphorus on performance, carcass and bone Hutcheson JP, Greene LW, characteristics, and calcium status in dicalcium phosphate 22 7757-93-9 Carstens GE and Byers FM 1992 growing lambs sheep J Anim Sci 1992. 70:1346-1351. Influence of Dietary Phosphate on Krishinaro GVG and Draper Bone dicalcium phosphate 22 7757-93-9 HH 1972 Resorption in Senescent Mice mice J. NUTRITION,102: 1143-1146. Impact of Prepartum Dietary dicalcium phosphate, Barton BA, Jorgensen NA Phosphorus Intake on Calcium monosodium phosphate 22 7757-93-9 & DeLuca HF 1987 Homeostasis at Parturition cows J Dairy Sci 70:1186-1191 tricalcium phosphate Mutagenic evaluation of compound. S. typhimuium, (refers by CAS No. to ß- FDA 75-30, tricalcium phosphate, Saccharomyces TCP) 23 7758-87-4 Brusick D 1976 NF,FCC cerevisiae Litton Bionetics Inc. NTIS PB257879 tricalcium availability of dietary phosphorus in B. Jap. Soc. Scient. Fisheries 45(12): 1527- bis(orthophosphate) 23 7758-87-4 Ogino C. et al 1979 carp and rainbow trout fish 1532 tricalcium bis(orthophosphate) (ß- Kinetics of dissolution of ß-tricalcium Journal of colloidal and interface science. 190: TCP) 23 7758-87-4 Bohner M 1997 phosphate. 37-48 Initial submission: Primary skin irritation of sodium Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- tricalcium phosphate (TCP) 24 1306-06-5 FX 1972 rabbits Rabbits 1861) HAP (24) (also looks at Jantova S, Theisova M, In vitro effects of fluor- microorganism fluorinated compounds in 24 1306-06-5 Letasiova S, Birosova L 2008 hydroxyapatite, fluorapatite and s Mutation Research. 625:139-144 tricalcium phosphate (as Gastrointestinal tolerance of oral ‘posture’) 24 12167-74-7 O’Connell MA et al 1989 calcium supplements human Clin pharm. 8: 425-427.

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Ossopan’ - Reid IR, Hannan SF, microcrystalline Shooler BA and Ibbertson The acute biochemical effects of four hydroxyapaptite 24 1306-06-5 HK 1986 proprietary calcium preparations. human Aust NZ J Med. 16:

an immunological study of tricalcium phosphate supplied by three different tricalcium phosphate (TCP) 24 12167-74-4 Sasaoka K. et al 1989 manufacturers guinea pigs J. Clin. Lab. Immunol. 30: 197-202

Mallaiah K.V., Padma Effect of phosphorous nutrition on Rami Y. and Vijaya growth and sporulation of Alternaria tricalcium phosphate 24 235-330-6 Lakshmi M. 1981 macrospora and Drechslera rostrata fungus indian j. microbiol 21: 169-170

T. Castaneum, pathological changes induced in C. Cephalonica, tricalcium phosphate (TCP) 24 12167-74-4 Bano, A., Majumder, S.K. 1965 insects E. Cautella J. of Invertebrate pathology 7 Tricalcium phosphate, Defluorinated phosphate rock, defluorinated Nutrative evaluation of deflourinated superphosphate, phosphates and other phosphorous supplements. II. Defluorinated 24 12167-74-7 Bird HR, Mattingly JP 1945 phosphates chicken J Assoc of Agric Chem. 28:118-129 Formation of hydroxyapatite at low hydroxyapatite (HAP) 24 1306-06-5 Boskey AL 1976 supersaturation. N/A The Journal of physical chemistry. 80:1 40-45 The mechanism of dissolution of hydroxyapatite and carbonated hydroxyapatite (HAP) 24 1306-06-5 Budz JA 1988 apatite in acidic solutions. N/A Journal of crystal growth. 91:490-496

Physico-chemical characterization HAP (Gen-OxTM – natural, and biocompatibility evaluation of HA-U-synthetic) 24 1306-06-5 Cabral da Cruz AC et al 2006 hydroxyapatites N/A Journal of Oral Science. 48(4): 219-226

Solubility criteria for the existence of hydroxyapatite (HAP) 24 1306-06-5 Clark JS 1955 hydroxyapatite. N/A Canadian journal of chemistry. 33:1696-1700 The preparation of hydroxyapatite, Hydroxyapatite (HAP) 24 1306-06-5 Clark LM and Gerrard WF 1938 3[Ca3(PO4)2], Ca(OH)2 N/A J Soc Chem Ind, 7: 295-297 Danneel H and Frohlich Uber das system tricalcium phosphat tricalcium phosphate (TCP) 24 1306-06-5 KW 1930 und wasser N/A Z. Anorg Chem 188:14-31

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

structure of DNA – binding to calf thymus Indian Journal of biochemistry and biophysics hydroxyapatite (HAP) 24 1306-06-5 Dutta. S., Sasisekharan V. 1982 hydroxyapatite as a probe DNA 19: 71-74 JCPDS-International Centre for Diffraction Elliott JC, Wilson RM and Data 2002, Advances in X-ray analysis. 45: hydroxyapatite (HAP) 24 1306-06-5 Dowker SEP 2002 Apatite structures N/A 172- Toxicity of Hydroxyapatite in vitro : Hydroxyapatite (HAP) 24 1306-06-5 Evans EJ 1990 the effect of particle size. N/A Biomaterials, 12: 574-576 Studies on the Mechanisms of cell damage by finely ground Hydroxyapatite (HAP) 24 1306-06-5 Evans EJ et al 1991 HydroxyapatiteInfrared studies Particlesof apatites. in vitroI. N/A Clinical materials, 7: 241-245 Vibrational assignments for calcium, hydroxyapatite (HAP) 24 12167-74-4 Fowler BO 1973 strontium and barium n/a Inorganic Chemistry. 13:194-214

Solubility behaviour of dental enamel Hydroxyapatite (HAP) 24 1306-06-5 Francis MD 1965 and other Calcium Phosphates N/A Ann NY Acad Sci, 131(2): 694-712 Effect of dietary calcium phosphate and zinc supplementation on whole body zinc concentration of rainbow tricalcium phosphate (TCP) 24 12167-74-7 Hardy RW and Shearer KD 1985 trout (Salmo gairdneri). fish Can. J. Fish. Aquat. Sci. 42: 181-185 Dental materials which contain tricalcium phosphate 24 12167-74-7 Heil J 1996 Genotoxicity of dental materials N/A Mutation Research 368: 181-194 The Solubility behaviour of Hydroxyapatite (HAP) 24 1306-06-5 La Mer VK 1962 hydroxylapatite N/A J Phys Chem, 55: 973-978

reversion of the toxicity of tricalcium tricalcium phosphate (TCP) 24 12167-74-4 Majumder S.K., Bano A. 1966 phosphate to insects by Trehalose insects Nature 210: 1052-1053 Calcium phosphate biomaterials: a Hydroxylapatite coatings in orthopaedic hydroxyapatite (HAP) 24 1306-06-5 Manley MT 1993 review of the literature. surgery. 1-23 Biological effects of calcium hydroxyapatite crystals in breast Hydroxyapatite (HAP) 24 1306-06-5 McCarthy G 2001 cancer solubility of Ca5(PO4)3OH in the Journal of research of then Nation Bureau of McDowell H, Gregory TM system Ca(OH)2-H3PO4-H2O at 5, Standards A. Physics and Chemistry. 81A (2 hydroxyapatite (HAP) 24 1306-06-5 and Brown WE 1977 15, 25 and 37°C. N/A and 3): 273- 281 calcium hydroxyapatite promotes mitogenesis and matrix metalloproteinase expression in human tissue hydroxyapatite (HAP) 24 1306-06-5 Morgan M.P. 2001 human breast cancer cell lines cells molecular carcinogenesis 32: 111-117

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Niwa S, Sawai K, Experimental studies on the Takahashi H, Tagai H, Ono implementation of hydroxyapatite in hydroxyapatite (HAP) 24 1306-06-5 M and Fukuda Y 1980 the medullary canal of rabbits. rabbit Influence of the purity of tricalcium Rao M.R., Venugopal J.S. phosphate on its toxicity to stored- insect tricalcium phosphate (TCP) 24 12167-74-4 And Majumder S.K. 1971 product insects (tribolium) Life science 10(II): 1081-1088 basic calcium phosphate Rootare HM, Deitz VR and solubility product phenomena in (HAP) 24 1306-06-5 Carpenter FG 1962 hydroxyapatite water systems. N/A Journal of colloid science. 17:179-206

Effect of dietary tricalcium phosphate tricalcium phosphate (TCP) 24 1306-06-5 Satoh S et al 1987 on availability of zinc to rainbow trout fish Nippon Suisan Gakkaishi. 53(7): 1199-1205

Effect of supplemental phytate and/or tricalcium phosphate on weight gain, feed efficiency and zinc content in tricalcium phosphate (TCP) 24 1306-06-5 Satoh S et al 1989 vertebrae of channel catfish. fish Aquaculture. 80: 155-161

The estimation of acid needed to obtain a saturated solution in hydroxyapatite (HAP) 24 1306-06-5 Smith AN 1975 equilibrium with solid hydroxyapatite. N/A Journal of Colloid and Interface Science, 54:2 A model describing the kinetics of hydroxyapatite (HAP) 24 1306-06-5 Smith AN 1977 dissolution of hydroxyapatite. N/A Journal of Colloid and Interface Science, 62:3 Incongruent dissolution and surface hydroxyapatite (HAP) 24 1306-06-5 Smith RN 1974 complexes of hydroxyapatite N/A Journal of Colloid and Interface Science, 48:3 Short-term carcinogen-induced hydroxyapatite (HAP) 24 1306-06-5 Stewart BW 1976 structural changes in DNA in vivo. N/A IARC Scientific Publications. No. 12 : 343-350 Solubility products of di—and 24: HAP trimagnesium phosphates and the di- and tri- Magnesium dissociation of magnesium phosphate 24 1306-06-5 Taylor AW 1963 phosphate solutions. N/A Trans Faraday Soc. 59: 1580-1584 Kinetics of dissolution of calcium hydroxyapatite powder. III: pH and hydroxyapatite (HAP) 24 1306-06-5 Thomann JM 1990 sample conditioning effects N/A Calcif Tissue Int. 46:121- 129. Toth JM, Hirthe WM, hubbard WG, Brantley WA Determination of the ratio of HA/TCP hydroxyapatite / TCP 24 12167-74-7 & Lynch KL 1991 mixtures by x-ray diffraction n/a Journal of Applied Biomaterials. 2:37-40 Effect of Supplemental Tricalcium Satoh SH, Izume K, Phosphate on Zinc and Manganese tricalcium phosphate 24 12167-74-7 Takeuchi T and Watanbe T 1992 Availability to Common Carp fish Nippon Suisan Gakkaishi. 58(3): 539-545

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Sequential study of Pleural Peritoneal and blood cells in acute pleurisy Induced by Calcium Pyrophosphate Calcium Pyrophosphate 25 14866-19-4 Bachelet CM et al 1987 in the Rat. rat Experimental Lung Research, 13:241-252 the effects of calcium acid phosphate calcium acid phosphate on dental caries in children: a (CAPP) 25 14866-19-4 Ship I.I. And Mickelsen O. 1964 controlled clinical trial human J. D. res suppl num 6, 43: 1144-1149 Calcium pyrophosphate dihydrate (monoclinic), Roch-Arveiller M, Legros R, calcium pyrophosphate Chanaud B, Muntaner O, dihydrate (triclinic) and Strzalko S, Thuret A, Inflammatory reactions induced by calcium pyrophosphate Willoughby DA and Giroud various calcium pyrophosphate anhydrous ( β) 26 JP 1990 crystals. rat Biomed and Pharmacother. 44: 467-474 monoclinic or triclinic calcium pyrophosphate dihydrate crystals, ‘apatitie’ Comparison of the acute crystals (could be HAP, inflammation induced by calcium fluoroapatite, chlorapatite pyrophosphate dihydrate, apatite and or bromapatite – not Watanabe W, Baker DG mixed crystals in the rat air pouch stated) 26 and Schumacher HR 1992 model of a synovial space chicks J Rhumatol 19(9): 1453-1457 Initial submission: Primary skin irritation of sodium Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- Ferric phosphate (FeP) 27 10045-86-0 FX 1972 rabbits Rabbits 1861) Responses of the earthworm Lumbricus terrestris (L.) to iron phosphate and metaldehyde slug Ferric phosphate (FeP) 27 10045-86-0 Langan MA and Shaw EM 2006 pellet formulations. earthworms Applied soil ecology, 34: 184-189 Mutagenic evaluation of compound FDA 73-84 Ferric ortho phosphate Yeast and iron phosphate (FeP) 27 10045-86-0 Brusick D 1975 white food grade, phase I Bacteria NTIS Sodium iron pyrophosphate Biological Availability of Iron Ferric orthophospahte Supplements for Rats, Chicks and Rats, chicks, 27 10045-86-0 Pennell MD et al 1976 Humans humans Journal of Nutrition, 106(2): 265-274

A new low-toxicity slug control Iron phosphate (FeP) 27 10045-86-0 Caldwell B 2001 material for strawberries. Slug NYS IPM program

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Genotoxicity of Iron Compounds in Salmonella Typhimurium and Environmental and Molecular Mutagenesis, 33: Iron phosphate (FeP) 27 10045-86-0 Dunkel VC et al 1999 L5178Y Mouse Lymphoma Cells mouse 28-41 The relative toxicity of metaldehyde and iron phosphate-based iron phosphate (FeP) 27 10045-86-0 Edwards CA et al 2009 molluscicides to earthworms Earthworms Crop protection, 28: 289-294

Estimation of the bioavailability of Iron phosphate (FeP) 27 10045-86-0 Fritz JC et al 1975 iron. Journal of the AOAC. 58(5): 902-905

Field tests with a molluscicide iron phosphate (FeP) 27 10045-86-0 Speiser B and Kistler C 2002 containing iron phosphate Slug Crop protection 21: 389-394

A compilation of two decades of bacteria mutagencity test resuls with the salmonella Seifried HE, Seifried RM, Ames Salmonella typhimurium and (ames test), Ferric phosphate (FeP) - Clarke JJ, Junghans TB L5178Y Mouse lymphoma cell mouse hydrate 27 51833-68-2 and San RHC. 2006 mutation assays. lymphoma cells Chem. Res Toxicol. 19: 627-644 Prepared for the EU Review report for the active Ferric phosphate (FeP) 27 10045-86-0 Commission 2002 substance ferric phosphate Human European Commission

Carter SR and Hartshorne The System Ferric Oxide-Phosphoric Iron phosphate (FeP) 27 10045-86-0 NH 1923 Acid – Water. A New Phosphate N/A J Chem Soc Trans 123: 2223-2233

Iron phosphate (FeP) 27 10045-86-0 Chang SC and Jackson ML 1957 Solubility product of iron phosphate. water and soil Soil Sci Soc Am J. 21:265-269 Hazardous Substances Hazardous Substances Data Bank, Ferric phosphate (FeP) 27 10045-86-0 Data Bank, 2004 Ferric phosphate Human TOXNET complexes invloving tervalent iron and orthohposphoric acid. Part III. The system ferric oxide-phosphoric Ferric phosphate (FeP) 27 10045-86-0 Jameson RF and Salmon 1954 oxide-water at 25° N/A J Chem Soc. Unknown vol: 28-34

Effect of dietary iron level on Mahoney AW and efficiency of converted food iron into Ferric phosphate (FeP) 27 10045-86-0 Hendricks DG 1976 haemoglobin by the anaemic rat. rat Nutr. Metabol. 20: 222-227

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Rat, bird, fish, aquatic invertebrates, algae, Environmental fate - Ecotoxicology - earthworms, Human Health Ferric Phosphate arthropods, Iron phosphate (FeP) 27 10045-86-0 N/A 1997 PPDB human PPBD (data base) Prepared for the EU Review report for the active Ferric phosphate (FeP) 27 10045-86-0 Commission 2002 substance ferric phosphate Rat European Commission Mouse, Prepared for the EU Review report for the active hamster, Ferric phosphate (FeP) 27 10045-86-0 Commission 2002 substance ferric phosphate guinea pig European Commission The effects of metals on the chick Ridgway LP and Karnofsky embryo: toxicity and production of iron phosphate (FeP) 27 10045-86-0 DA 1952 abnormalities in development. chick embryo Ann N Y Acad Sci: 203-215

An iron-based T1 contrast agent made of iron-phosphate complexes: Iron phosphate (FeP) 27 10045-86-0 Rodriguez E et al 2007 In vitro and in vivo studies. mice Magn reson Mater Phy, 20: 27-37 Synthesis, Characterization, and Bioavailability in Rats of Ferric Iron phosphate (FeP) 27 10045-86-0 Rohner F et al 2007 Phosphate Nanoparticles Rats The Journal of Nutrition, 137: 614-619 complexes invloving tervalent iron and orthophosphoric acid. Part II. Ion- exhange studies of solutions iron phosphate (FeP) 27 10045-86-0 Salmon JE 1952 containing phosphate and chloride n/a J Chem soc: 2644-2650 Provisional Evaluation of the use of "Ferramol Schneckenkorn" in Research Institute of Organic Agriculture Iron phosphate (FeP) 27 10045-86-0 Tamm L and Speiser B 2006 Organic Farming in Switzerland. Slugs/snails (FiBL), Frick, Switzerland Fidler MC, Walczyk T, Davidsson L, Zeder C, A micronized, dispersible ferric Sakaguchi N, Juneja LR pyrophosphate with high relative Iron pyrophosphate (FePP) 28 10058-44-3 and Hurrel RF 2004 bioavailability in man. human British Journal of Nutrition. 91:107-112 Effects of Ascorbic acid on Interactions between Ciprofloxacin and Ferrous Sulphate, Sodium Ferric pyrophosphate Ferrous Citrate or Ferric (FePP) 28 10058-44-3 Motoya T et al 2000 Pyrophosphate, in mice. mice J Pharm Pharmacol 52:397-401

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Salt Dual-Fortified with Iodine and Micronized Ground Ferric Pyrophosphate Affects Iron Status ferric pyrophosphate but Not Hemoglobin in Children in (FePP) 28 10058-44-3 Wegmuller R et al 2006 Cote d'Ivoire. Human Journal of Nutrition, 136(7): 1814-1820 Mutagenicity and DNA-damaging activity caused by deomposed Kitano K, Fukukawa T, products of potassium sorbate bacteria Ohtsuji Y, Matsuda T and reacting with ascorbic acid In the salmonella Iron pyrophosphate (FePP) 28 10058-44-3 Yamaguchi H 2002 presence of Fe salt. (ames test) Food and chemical toxicology 40: 1589-1594 Chow FC, Taton GF, Baulay JP, Lewis LD, Effect of dietary calcium, dimagnesium phosphate Remmenga EE and Hamar magnesium and phosphorous on (DMP) 29 7757-86-0 DW 1980 phosphate urolithiasis in rats. rat Investigative Urology. 17(4): 273-276 Separation and detection of condensed phosphates in waste dimagnesium phosphate Halliwell DJ, Mackelvie ID, waters by ion chromatography (DMP) 29 7757-86-0 Hart BT and Dunhill RH 1996 coupled with flow injection. n/a Analyst. 121:1089-1093. Phosphoric acid, sodium phosphates, potassium phosphates, calcium Food additives in Europe 2000 - phosphates, status of safety assessments of food monomagnesium additives presently permitted in the phosphate, dimagnesium 29 7757-86-0 EU. Initial submission: Primary skin irritation of sodium trimagnesium Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- bis(orthophosphate) (TMP) 30 7756-87-1 FX 1972 rabbits Rabbits 1861)

Nasal toxicity of manganese sulphate and manganese phosphate in young manganese phosphate male rats following subchronic (13 (hureaulite) (MMangP) 34 18718-07-5 Dorman D.C. Et al 2004(a) week) inhalation exposure rats inhalation toxicology 16(6): 481-488 manganese phosphate (hureaulite) (MMangP) 34 18718-07-5 Dorman DC et al 2004(b) 30 and 90 day inhalation exposure rats

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Assessment of bioaccumulation, neuropathy, and neurobehavious following subchronic (90 days) manganese phosphate inhalation in Sprague-Dawley rats Toxicology and applied pharmacology 183: (hureaulite) (MMangP) 34 18718-07-5 Normandin L. et al 2002 exposed to manganese phosphate Rats 135-145 manganese phosphate (hureaulite) (MMangP) 34 18718-07-5 Viteralla D 2000 5 and 7 week inhalation exposure rats

Diffraction patterns and solubility Manganese phosphate products of several divalent (MMangP) 34 18718-07-5 Boyle FW and Lindsay WL 1985 manganese phosphate compounds. N/A Soil Sci Soc Am J. 49(3): 761-766 Manganese phosphate Manganese phosphate equilibrium (MMangP) 34 18718-07-5 Boyle FW and Lindsay WL 1986 relationships in soils. SOIL Soil Sci Soc Am J. 50(3): 588- Preparation, x-ray diffraction pattern manganese III phosphate and solubility product of manganese (MMangP) 34 18718-07-5 Boyle FW and Lindsay WL 1985 (III) phosphate hydrate. N/A Soil Sci Soc Am J. 49: 758-760 Das ternare system manganophosphate-phosphorsaure- manganese hydrogen wasser und die phosphate (DMangP) 35 51349-94-1 Grube G and Staesche M 1927 diphosphatomanganosaure. N/A Z Physik Chem. 13:572-583

Chimie minerale - sur les dicopper hydroxide orthohposphates du cuivre. Etude du phosphate (CuHP) 38 12158-74-6 Huerin H and Kozicki H 1952 systeme P2O5-Ocu-OH2 a 60 et 18° N/A Compt Rend 235: 52-1952 aluminium phosphate Article: Dale JC and King EJ. Acute Archives of Industrial Hygiene and (MALP) 39 13530-50-2 Drinker P 1953 toxicity of mineral dusts. mice Occupational Medicine Vol 7: 478-483

Screening of environmental chemical Aluminium orthophosphate Kada T, Hirano K and mutagens by the Rec-Assay system (TALP) 40 7785-30-7 Shirasu Y 1980 with Bacillus subtilis bacteria Chem Mutagens. 6:149-173

Aluminium orthophosphate Kanematsu N, Hara M and Rec assay and mutagenicity studies (TALP) 40 7785-30-7 Kada T 1980 on metal compounds bacteria Mutation Research .77:109-116

Mineral metabolism of rats fed Aluminium phosphate Greger JL, Bula EN and moderate levels of various aluminium (TALP) 40 7784-30-7 Gum ET 1985 compounds for short periods of time. Rat J. Nutr. 115:1708-1716

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Aluminium orthophosphate Brosheer JC, Lenfesty FA Solubility in the system aluminium (TALP) 40 7785-30-7 and Anderson JF 1954 phosphate-phosphoric acid-water N/A J Am Chem Soc. 76:5951-5956

Aluminium orthophosphate Chimie minerale - sur les phosphates (TALP) 40 7784-30-7 Guerin H and Martin R 1952 d'aluminium N/A Compt Rend. 234:1777-9 Aluminium compounds, Review of Aluminium orthophosphate Toxicological Literature Abridged (TALP) 40 7785-30-7 Masten S 2000 Final Report Some human The crystal structure of aluminium Aluminium orthophosphate phosphate and gallium phosphate, (TALP) 40 7785-30-7 Mooney RCL 1956 low-cristobalite type N/A Acta Cryst. 9: 728 Studies of the preparation and physical properties of multivalent metal condensed phosphates. V. The Aluminium orthophosphate Tsuhako M , Motooka I and grinding of various aluminium Bulletin of the Chemical Society of Japan. 46: (TALP) 40 7785-30-7 Kobayashi M 1973 phosphates. n/a 2343-2346 Yayt BB et al COULD NOT Aluminium orthophosphate BE Experimental and Clinical Pharmacology. 62: (TALP) 40 7785-30-7 1999 62: 37-39 TRANSLATED 37-39 Studies of the preparation and physical properties of multivalent metal condensed phosphates. XI. Tsuhako M , Hasegawa K, The preparation of various aluminium Aluminium Matsuo T, Motooka I and phosphates and their thermal Bulletin of the Chemical Society of Japan. tripolyphosphate 41 13939-25-8 Kobayashi M 1975 transformation N/A 48(6): 1830-1835

Aluminium metaphosphate 42 13776-88-0 Van Der Meer H 1976 Acta Cryst. B25: 2423-2426 n/a Acta Cryst. B25: 2423-2426 a six month dietary toxicity study of sodium aluminium acidic sodium aluminium phosphate phosphate (SALP) 43 7785-88-8 Katz A.C. Et al 1984 in beagle dogs dogs (beagle) Fd. Chem. Toxic. 22(1): 7-9 Mutagenic evaluation of compound. sodium aluminium FDA 75-1. 007785-88-8, sodium S. typhimuium, phosphate (SALP, acidic, aluminium phosphate (acidic) F.C.C. Saccharomyces levair) 43 7785-88-8 Brusick D 1975 grade levair cerevisiae Litton Bionetics Inc. NTIS PB254520 Environmental Geochemistry and Health , ISSN sodium aluminium Twenty-six week toxicity study with 0269-4042 (Print) 1573-2983 (Online), 12 ( 1- phosphate (SALP) 43 7785-88-8 Pettersen J.C. Et al 1990 KASAL in beagle dogs dogs 2): 121-123

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Basic Sodium Aluminium Phosphates (SALP); KASAL and KASAL II. These are autogenous mixtures of alkaline sodium aluminium phosphate and dibasic sodium phosphate. Toxicity and Aluminium KASAL contains approx concentration in bone following 6% Al and KASAL II dietary administration of two sodium contains approx 13% Al. aluminium phosphate formulations in 43 7785-88-8 Hicks JS et al 1987 rat. rat Fd chem toxic, 25(7): 533-538

Aluminium bioavailability from the approved food additive leavening agent acidic sodium aluminium sodium aluminium Yokel R.A. And Florence phosphate, incorporated into a baked phosphate (SALP) 43 7785-88-8 R.L. 2006 good, is lower than from water Rats Toxicology 227: 86–93

Acidic sodium aluminium phosphate (SALP) 43 7785-88-8 Yokel RA 2005 Al bioavail ability from food N/A Toxicol Sci 84(1-S): 230-1 Aluminum bioavailability from basic sodium aluminum phosphate, an sodium aluminium Yokel RA, Hicks CL, approved food additive emulsifying Food Chem Toxicol. 2008 June ; 46(6): phosphate (SALP) 43 7785-88-8 Florence RL 2008 agent, incorporated in cheese rat 2261–2266. Sodium aluminium phosphate(acidic sodium aluminium and basic)(WHO food additives phosphate (SALP) 43 7785-88-8 WHO series 1) mouse Initial submission: A two year inhalation toxicity study of calcium sodium calcium sodium metaphosphate fiber in the Biodynamics Inc. Project No. 85-7802. polyphosphate 45 23209-59-8 Anon 1990 rat. rat Monsanto Document Id No. 88-920005007. dehydroxylation mechanisms of sodium calcium Gomez F, Vast P, Llewellyn polyphosphate glasses in relation to polyphosphate 45 23209-59-8 P and Rouquerol F 1997 temperature and pressure. n/a Journal of non-Crystalline Solid. 222: 414-421 Toxicity of calcium sodium metaphosphate fibre. In vitro and in calcium sodium vivo degradation and clearance metaphosphate (CSM) 45 23209-59-8 Nair R.S. Et al 1992 studies Rats fundamental and applied tox. 19: 69-78

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium calcium Low fibrosarcoma incidence seen for polyphosphate 45 23209-59-8 Unknown author 1986 phosphate fiber test. rat Pesticide and Toxic Chemical News. 8 research in mammals with sodium potassium radioactive high polymers phosphate tripolyphosphate (SKTP) 46 24315-83-1 Gotte H. 1953 markers dogs z naturforsch 8(b):173 Mutagenicity of cosmetics ingredients disodium fluorophosphate Gocke E, King MT, licensed by the European (SFP) 47 10163-15-2 Eckhardt K and Wild D 1981 Communities. Mutation Research. 90: 91-109. Micronucleus tests in mice on 39 disodium fluorophosphate Hayashi M, Kishi M, Sofuni food additives and eight (SFP) 47 10163-15-2 T and Ishidate M 1988 miscellaneous chemicals. Mouse Fd Chem. Toxic. 26(6): 487-500. Chronic toxicity of dietary sodium monofluorophosphate in growing disodium fluorophosphate rats, with special reference to kidney Acta path. Et microbiol. Scandinav. 65:493- (SFP) 47 10163-15-2 Poulsen H & Ericsson Y 1965 changes rat 504 Buchi R. Induced dominant lethal mutation and cytotoxic effects in germ cells of drosophila melanogaster with disodium fluorophosphate trenimon, PDMT and sodium d. (SFP) 47 10163-15-2 1977 monofluorophosphate. melanogaster Gentae genetics,87: 67-81 disodium fluorophosphate LD50 in the mouse compared to the (SFP) 47 10163-15-2 Lim J.K. Et al 1978 rat mice and rats Caries Res. 12: 177-179

preliminary studies of the caries disodium fluorophosphate inhibiting potential and acute toxicity (SFP) 47 10163-15-2 Shourie K.L. Et al 1950 of sodium monofluorophosphate hamster J. D. Res 29: 529

Acute oral toxicity of sodium fluoride disodium fluorophosphate Whitford GM, Birdsong- and monofluorophosphate separately (SFP) 47 10163-15-2 Whitford NL and Finidori C 1990 or in combination in rats. rat Caries Res. 24: 121-126 induced dominant lethal mutations disodium fluorophosphate and cytotoxic effects in germ cells of Drosophila (SFP) 47 10163-15-2 Buchi R. 1977 Drosophila melanogaster melanogaster gentae Genetics 87(): 67 The distribution in the mammal body disodium fluorophosphate Ericsson Y and of F18 and P32 from double-labelled (SFP) 47 10163-15-2 Hammarstrom L 1965 Na2PO3F rats and mice Acta physiol. Scand. 65:126-137

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Absorption and metabolism of the PO3F ion in the animal body. Studies disodium fluorophosphate Ericsson Y, Santesson G with F18, P32-labelled sodium Arch. Oral Biol. Special Supplement. 4:160- (SFP) 47 10163-15-2 and Ullberg S 1961 monofluorophosphate. 174. disodium fluorophosphate Gruninger SE, Clayton R, Acute oral toxicity of dentrifrice (SFP) 47 10163-15-2 Chang SB and Siew C 1988 fluorides in rats and mice. rats, mice J Dent Res. 67:884 Short-term feeding studies on sodium fluorophosphate (Na2PO3F) Atomic Enery Project Rep. UR-200. Q. Tech. disodium fluorophosphate Maynard EA and Downs and potassium hexafluorophosphate rep. US atomic energy commision . Univ (SFP) 47 10163-15-2 WL 1951 (KPF6) in rats rat Rochester Oct 1-Dec 33: 24-26 Fluorine storage in rats receiving disodium fluorophosphate Muhler JC, Weddle DA, different flourines in the drinking (SFP) 47 10163-15-2 Stewart JO 1955 water at varying pH rat J. Dent. Res. 34:895-899 The effect of 0.05 per cent dietary sodium fluoride n/a n/a Pindborg J 1957 sodium fluoride on the rat kidney rat Acta pharmacol et toxicol. 13:36-45 Incorporation of fluoride in bones and teeth and dental fluorosis in mice disodium fluorophosphate Ruzicka JA, Mrklaus L and after administration of complex (SFP) 47 10163-15-2 Rokytova K 1974 fluorides mice Archs oral Biol. 19: 947-950 Chemical stability and mode of disodium fluorophosphate gastrointestinal absorotion of sodium (SFP) 47 10163-15-2 Setnikar I and Arigoni R 1988 monoflurophosphate. Arzneim Forsch. 38(1): 45-49 Caries Res. 17 (Suppl. 1): 36-45 in: Karger S (1983) Monofluorophosphate perspectives. Caries Research. Journal of the European disodium fluorophosphate Smith FA and Hodge HC Organisation for Caries Research. (Filename: (SFP) 47 10163-15-2 (most important article) 1983 Toxicology of monoflurophosphate. various Nijmegen caries research) disodium fluorophosphate Smith FA, Downs WL, Screening of fluorine-containing (SFP) 47 10163-15-2 Hodge HC & Maynard EA 1960 compounds for acute toxicity mice Toxicity and Applied Pharmacology. 2 : 54-58 Toxicity of fluoride-containing dental sodium fluorophosphate 47 10163-15-2 Smith GE 1985 preparations: a review. various The science of the total environment. 43:41-61 Absorption of various fluorine disodium fluorophosphate compounds from the gastrointestinal (SFP) 47 10163-15-2 Zipkin I & Likins RC 1957 tract of the rat rat Am J Physiol. 191: 547-550 Fluoride exposure and bone status in Sodium patients with chronic intestinal failure monofluorophosphate who are receiving home parenteral (SFP) 47 10163-15-2 Boulétreau PH et al 2006 nutrition. human Am J Clin Nutr 83:1429-1437

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Sodium fluoride promotes morphological transformation of sodium fluoride n/a n/a Jones CA et al 1988 Syrian Hamster embryo cells. hanster Carcinogenesis 9(12): 2279-2284 Laboratory Studies Concerning the Effectiveness and Safety of Various disodium fluorophosphate Stookey G.K., Hudson J.T. Fluoride and Fluoride-Phosphate (SFP) 47 10163-15-2 and Muhler J.C. 1967 Systems. human, rat J. Dent. Res., 46(3): 503-513 sodium fluorophosphate Inorganic fluorides used in drinking (SFP) 47 10163-15-2 WHO 1982 water and dental preparations N/A Complex fluorides: caries reduction disodium fluorophosphate and fluorine retention in the bones (SFP) 47 10163-15-2 Zipkin I & McClure FJ 1951 and teeth of white rats rat Public Health Reports. 66(47): 1523-1532 Hill WL, Faust GT and phosphoric acid 48 7664-38-2 Hendricks SB 1943 Polymorphism of phosphorus oxide, n/a J. Am. Chem. Soc., 65: 797-804. Absence of mutagenic activity of ames phosphoric acid 48 7664-38-2 Al-Ani F.Y., Al-Lami S.K. 1988 acidity regulators salmonella Mutation research, 206():467-470 Effect of different acids on the phosphoric acid 48 7664-38-2 Alkahem HF 1989 freshwater fish Aphanius dispar. fish J Biol Sci Res, 20(3): 537-545 Carbonated Beverage Consumption Phosphoric acid 48 7664-38-2 Amato D et al 2001 and Bone Fractures N/A Arch Pediatr Adolesc Med 155(2):200-201

Acute effects on soft drink intake on calcium and phosphate metabolism Phosphoric acid 48 7664-38-2 Amato D et al 1998 in immature and adult rats. rats Rev Invest Clin 50: 185-189

Toxic effects of two dental materials on human buccal epithelium in vitro human tissue phosphoric acid 48 7664-38-2 Arenholt-bindslev D. et al 1987 and monkey buccal mucosa in vivo cells scand j dent res 95: 467-474

the effect of a prolonged intake of phosphoric acid 48 7664-38-2 Bonting S.L. 1952 phosphoric acid and citric acid in rats Rats dissertation

Phosphoric acid 48 7664-38-2 Brown E.H and Whitt C.D. 1952 Vapour pressure of phosphoric acids. n/a Ind. Eng. Chem. 44,3:615-618 Agents and actions, vol 11, no 5, page 515 phosphoric acid 48 7664-38-2 Bucher K et al 1981 skin irritation potential mice onds Anals of Emergency Medicine, 16:8 August phosphoric acid 48 7664-38-2 Caravati M 1987 one acute human toxicity case report humans 1987, page 119/904 Handbook of Hazardous chemical phosphoric acid 48 7664-38-2 Cheremisinoff NP 2000 properties N/A N/A

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Blood phosphorus levels of laying hens at various time intervals after Phosphoric acid 48 7664-38-2 Choi JH et al 1979 dosing with phosphoric acid. hens J. Nutr. 109: 1515-1518 The phosphorus excretion pattern and balance during one egg cycle of the laying hen fed a phosphorus deficient diet with or without a signle Phosphoric acid 48 7664-38-2 Choi JH et al 1978 dose of phosphoric acid hens Unknown Journal Density of aqueous solutions of Christensen JH and Reed phosphoric acid. Measurements at Industrial and Engieneering chemistry. 47(6): phosphoric acid 48 7664-38-2 RB 25°C n/a 1277-1281 duck, rabbit, L'acide phosphorique. Son innocuite. horse, guinea- Sea principlaes indications en pig, dog, phosphoric acid 48 7664-38-2 Cadtru F 1904 therapeutique. human La Presse Medicale. 74 sea urchin sublethal pH decrease may cause (embryo and genetic damage to Eukaryotic Cell: A sperm) and study on Sea Urchins and Salmonella Teratogenesis, Carciogenesis and phosphoric acid 48 7664-38-2 Cipollaro. M. et al 1986 Salmonella typhimurium typhimurium Mutagenesis 6: 275-287 Demerec. M., Bertani G. a survey of chemicals for mutagenic American naturalist 85(821): 119-136 (see phosphoric acid 48 7664-38-2 and Flint J. 1951 action on E. Coli bacteria 123) Drahoslava Vyskocilova et phosphoric acid 48 7664-38-2 al 1983 workers IN RUSSIAN humans pracov lek, 35(2):76 effects of different acids on the Ellgaard E.G, Gilmore III bluegill sunfish, Lepomis phosphoric acid 48 7664-38-2 J.Y. 1984 macrochirus rafinesque fish j. Fish Biol. 25: 133-137 Chronic broncopneumopathy and pneumoconiosis in workers employed in phosphoric acid phosphoric acid 48 7664-38-2 Fabbri L. et al 1977 production human Lavoro Umano 27: 50-57 Phosphoric acid; toxic chemical release reporting; community right to phosphoric acid 48 7664-38-2 Federal register.55 1990 know n/a n/a threshold concentration of phosphorous acid 48 7664-38-2 Fedorencko vi et al 1991 phosporous acid in water ? unknown gig sanit 45():24

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Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in Phosphoric acid 48 7664-38-2 Fernando GR et al 1999 postmenopausal women human J. Clin. Epidemiol. 52(10):1007-1010.

The effect of 50 per cent phosphoric phosphoric acid 48 7664-38-2 Forsberg C.M. 1982 acid on oral soft tissues Rats Swed Dent J Supplement 15 Cola beverage consumption induces bone mineralisation reduction in Phosphoric acid 48 7664-38-2 Garcia-Contreras F et al 2000 Ovariectomized rats. human Arch. Med. Res. 31:360-365. Harrison W N., Bradberry S Phosphoric acid UKPID monograph. Phosphoric acid UKPID monograph. IPCS phosphoric acid 48 7664-38-2 M and Vale J A n/a IPCS INTOX databank. n/a INTOX databank. Carbonated beverages and urinary Phosphoric acid 48 7664-38-2 Heaney RP et al 2001 calcium excretion. human Am. J. Clin. Nutr. 74:343-347. Some paradoxical effects in Experimental Medicine and Surgery.V (2- phosphoric acid 48 7664-38-2 Hermann 1947 experimental pharmacology. n/a 3):160-162. High production volume information rat, sheep, system(HPVIS). HPV phosphoric acid full dossier off rabbit, human, High production volume information phosphoric acid 48 7664-38-2 Phosphoric acid . n/a web 22-12-08 S. typhimurium, system(HPVIS). Phosphoric acid . The tolerence of rabbit cornea for Bulletin of The Johns Hopkins Hospital. Phosphoric acid 48 7664-38-2 Hughes W.F. 1948 various chemical substances. Appendix I. 82:338-349 cytotoxicity of phosphoric acid on hamster lungs phosphoric acid 48 7664-38-2 Iijima S. et al 1993 cultured mamalian cells cells shigaku (odontology) 80(5): 1159-1165 Measurement of the toxicity of micro phosphoric acid 48 7664-38-2 Ishii H. et al 1981 chemicals to the activated sludge organisms suishitsu Odaku Kenkyu 4(4 suppl): 197-203 Two dilutions of phosphoric acid Phosphoric acid 48 7664-38-2 Jacobs G.A 1988 tested on eye. J Am. Coll. Toxicol. 11,6:724 An objective method for the phosphoric acid 48 7664-38-2 Jacobs G.A., Martens M.A. 1989 evaluation of eye irritation in vivo rabbits Fd. Chem. Toxic. 27(4): 255-258 Polyphosphate metabolism in the Jacobson L. and Halmann blue-green alga Microcystis Phosphoric acid 48 7664-38-2 M. 1982 aeruginosa. algae Journal of Plankton Research. 4,3:481-488 1992, Phosphoric acid prepared at the 44th Phosphoric acid 48 7664-38-2 JECFA 1995 JECFA n/a Phosphoric acid prepared at the 44th JECFA Various mamals and phosphoric acid 48 7664-38-2 Kristensen P 1993 Inorgani c Acid Aerosols humans Nordic Arbete oche Halsa 1: 7-54

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observations on the effect of chemical configuration on the edema- producing potency of acid, phosphoric acid 48 7664-38-2 Larson P.S. Et al 1956 aldehydes, ketones and alcohols rabbits j pharmac exp ther 116():119 Association between long-term consumption of soft drinks and variables of bone modeling and remodeling in a sample of healthy Phosphoric acid 48 7664-38-2 Libuda L 2008 German children and adolescents. human Am. J. Clin. Nutr. 88:1670-1677. The dermal irritancy/corrosion of 20 phosphoric acid 48 7664-38-2 Loden M. et al 1985 compounds in acqueous solutions Rabbits FAO rapport E 40023 ISSN 0281-9945 On phosphates and phosphoric acid as dietary factor in the calcium phosphoric acid 48 7664-38-2 Malm O J 1952 balance of man. human Unknown Journal phosphoric acid 48 7664-38-2 Malm OJ 1952 dietary balance calcium and P-acid humans Scand J Clin Lab Invest, 5, pages 75-84 Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in Phosphoric acid 48 7664-38-2 Mazariegos-Ramos et al 1995 children: a case-control study. human The J. Pediatr. 126(6):940-942 Evaluation of the EPA exposure Regulatory toxicology and Pharmacology. 29: phosphoric acid 48 7664-38-2 Morley KM 1999 assessment for phosphoric acid. N/A 309-318 The toxic effect of some phosphate phosphoric acid 48 7664-38-2 MsMeniman N.P. 1973 supplements fed to sheep sheep Australian Veterinarian J. 49: 150-152 The first dissociation constant for phosphoric acid from 0 to 50°. Nims LF (1933)The second dissociation constant of phosphoric acid from 20 to 50° J Am Chem Soc 56: 1110-1112, J Am Chem Phosphoric acid 48 7664-38-2 Nims LF 1934 N/A Soc 55: 1946-1951 Structure and properties of the condensed phosphates condensed phosphoric Parks JR and Van Wazer –reorganization theory and some acids 48 7664-38-2 JR 1957 applications N/A J Am Chem Soc, 79: 4890-97

Phosphoric acid, Phosphorous pentoxide, Phosphorous oxychloride, Payne MP, Shillaker RO Phosphorous pentachloride, phosphoric acid 48 7664-38-2 and Wilson AJ 1993 Phosphorous pentasulphide. various Toxicity Review 30. HSE Books.

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ABSTRACT : skin irritation tests on Randall D.J. And Robinson various concentrations of phosphoric phosphoric acid 48 7664-38-2 E.C. 1977 acid Rabbits monsanto phosphoric acid 48 7664-38-2 Reinl W 1956 toxicity IN G ERMAN Archiv fur Toxikologie, bd 16, S 158-181 Toxicological characteristics of phosphoric acid and some of its phosphoric acid ( and chromium salts used as a binder in Gig. Truda i Prof. Patol. v Tsv i Cher. various non -IP subs) 48 7664-38-2 Sigova N.V. 1983 refractory production. human , rat Metallurgii, M: 65-69 Handbook of toxic and hazardous chemicals. phosphoric acid ( and Handbook of toxic and hazardous Noyes Publications, Park Ridge, New Jersey, various non -IP subs) 48 7664-38-2 Sittig M. 1981 chemicals. n/a USA. Phosphoric Acid Volume I (Parts I & II) Marcel phosphoric acid 48 7664-38-2 Slack A.V. 1968 Phosphori c acid (book) n/a Dekker Inc, New York whole body exposures to a phosphoric acid : red phosphoric acids aerosol: 1. phosphorus/butyl rubber Spontaneous activity effects in wild http://aphis.usda.gov/wildlife_damage/nwrc/pu mixture 48 7664-38-2 Sterner RT 1993 rodent and avian species. birds, rodents blications/93pubs/9337.pdf Opinion of the scientific panel on dietetic products, Nutrition and allergies on a request from the The EFSA Journal 233.1- commission related to the tolerable phosphoric acid 48 7664-38-2 19 2005 upper intake level of phosphorus. rats The EFSA Journal 233.1-19

Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: Phosphoric acid 48 7664-38-2 Tucker KL 2006 the Framingham Osteoporosis study. human Am. J. Clin. Nutr. 84:936-942. Urben PG (Ed), complied Bretherick's Handbook of reactive phosphoric acid 48 7664-38-2 by : Pitt MJ 1999 chemical hazards. 6th Ed - vol 1. N/A N/A Urben PG (Ed), complied Bretherick's Handbook of reactive phosphoric acid 48 7664-38-2 by : Pitt MJ 1999 chemical hazards. 6th Ed - vol 2. N/A N/A Vanderzee CE and Quist The third dissociation constant of Phosphoric acid 48 7664-38-2 AS 1961 orthophosphoric acid. N/A J Phys Chem 65: 118-123

on the sensitivity to low pH of some Von Brehm J. and selected crustaceans (Daphnia and phosphoric acid 48 7664-38-2 Meijering M.P.D 1982 Gammarus, Crustacea) Crustaceans Arch. Hydrobiol. 95(1): 17-27 Toxicology Update: Phosphoric Phoshphoric acid 48 7664-38-2 Von Burg R. 1992 acid/phosphates. various Journal of Applied Toxicology. 12(4) 301-203

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ABSTRACT: Modified skin irritation study on 75% phosphoric acid in a phosphoric acid 48 7664-38-2 Weiner M. et al 1988 single rabbit rabbit ? Relationship between carbonated and other low nutrient dense beverages and bone mineral content Phosphoric acid 48 7664-38-2 Whiting SJ et al 2001 of adolescents human Nutr. Res. 21:1107-1115. phosphoric acid 48 7664-38-2 WHO 1964 WHO Food additives.24.65 human, rat WHO IPCS INCHEM phosphoric acid

Teenaged girls, carbonated beverage Phosphoric acid 48 7664-38-2 Wyshak G 2000 consumption and bone fractures human Arch. Pediatr. Adolesc. Med. 154:610-613 Toxicite comparee de divers acides phosphoric acid 48 7664-38-2 Guevelard F 1922 pour les poissons (Epinoches) fish CR Acad Sci. 175: 124-1242 Agentes acidulantes utilizados em phosphoric acid 48 7664-38-2 Nazario G 1952 alimentos ? Rev. Inst. Aldolpho, Lutz. 11: 141 orthophosphoric acid, On the difference in the poisonous pyrophosphoric acid, Gamgee A, Priestly J and activity of phosphorous in ortho-, metaphosphoric acid 48 7664-38-2 Larmuth L 1877 meta-, and pyrophosphoric acids n/a Journal of Anatomy and Physiology. 11: 255 The influence of hydrogen ion concentration of the minimum dissolved oxygen toleration of the Townsend LD and Cheyne silver salmon, Oncorhynchus kisutch phosphoric acid 48 7664-38-2 H 1944 (walbum). fish Ecology. 25(4):461-466 H. R. CROOKSHANK, F. E. KEATING, EARL Effect of chemical and enzymatic BURNETT, J. H. JONES agents on the formation of urinary AND calculi in fattening steers phosphoric acid 48 R. E. DAVIS 1960 cows J Anim Sci 1960. 19:595-600. Bremner JM and Douglas Decomposition of urea phosphates in Urea phosphate 51 LA 1971 soils. Soil Sci Am J. 35:575-578 Evaluation of Urea-phosphate as a Perez CB, Warner RG and source of nitrogen and phosphorous Cows and Urea phosphate 51 Loosli JK 1967 for ruminants Lambs J Animal Science. 26: 810-819 investigation of cavity-sealing Zinc phosphate 52 13598-37-3 Trail JS and Sausen RE 1962 abilities of zinc phosphate n/a J D Res. 41(3):525-536 ammonium magnesium Journal of radioanalytical and nuclear phosphate (struvite) 56 7785-21-9 Aage HK, et al 1997 The solubility of struvite. N/A chemistry. 223(1-2):213-215. ammonium magnesium Bouropoulos NC and Spontaneous precipitation of struvite phosphate (struvite) 56 7785-21-9 Koutsoukos PG 2000 from aqueous solutions N/A Journal of Crystal Growth. 213: 381-388

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested ammonium magnesium Uber orthophosphate (struvite) 56 7785-21-9 Bube K 1910 magnesiumammonimphosphate N/A Z. Anal Chem ammonium magnesium Thermodynamics of struvite phosphate (struvite) 56 7785-21-9 Buchanan JR et al 1994 formation. N/A American Society of Engineers. 37(2): 617-621 Solubility product of magnesium ammonium magnesium ammonium phosphate hexahydrate phosphate (struvite) 56 7785-21-9 Burns JR and Finlayson B 1982 at various temperatures. N/A Journal of Urology. 128: 426-427 ammonium magnesium The decomposition of Struvite: phosphate (struvite) 56 7785-21-9 Ribbe PH 1969 further evidence N/A mineralogical magazine, 37(286): 290 ammonium magnesium Solubility of magnesium ammonium Industrial and engineering chemistry. 18(11): phosphate (struvite) 56 7785-21-9 Uncles RF et al 1946 phosphate hexahydrate N/A 699-702 Struvite (MgNH4PO4.6H2O) ammonium magnesium solubility and its application to a phosphate (struvite) 56 7785-21-9 Webb KM and Ho GE 1992 piggery effluent problem. N/A Water Sci Tech. 26(9-11): 2229- 2232 ammonium magnesium phosphate (struvite) 56 7785-21-9 Whitaker A 1968 The decomposition of struvite N/A Mineralogical magazine. 36: 820-824 ammonium magnesium An improved computer model of phosphate (struvite) 56 7785-21-9 Wrigley TJ et al 1992 struvite solution chemistry N/A Talanta. 39(12): 1597-1603 Monocalcium phosphate, Sodium metaphosphate, Calcium metaphosphate Reactions of Metaphosphates in No organism, University Microfilms an Arbor Mich PhD 21, 9 7758-23-8 Donoso-Torres 1958 Soils tested in soil Thesis (No Mic 59-1192) trisodium phosphate anhydrous, sodium acid pyrophosphate, tetrasodium pyrophosphate, tripotassium phosphate, 4, 7, 14, monocalcium phosphate 21 7601-54-9 Parent R. 1990 ABSTRACT: no title Rabbits j am coll toxicol 1: 4: 48-49 Evaluation of phosphate toxicity in Cope's Gray Treefrog (Hyla sodium phosphate' ? ? Earl JE and Whiteman HH 2010 chrysoscelis) Tadpoles tadpoles Journal of Herpetology. 44(2): 201-208

? ? ? ? 1938 ? N/A Zh Obschch Khim. 8:1230-1231 mg phosphates ? ? Belopolskii AP et al 1950 ? (Title i n Russian) N/A Zh Prikl Chim. 23: 823-36

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Metal complexing by phosphorus compounds. I. The thermodynamics of association of linear STPP 0, (11?), 7 7758-29-4 Irani R.R. and Callis C.F. 1960 polyphosphates with calcium. J. Phys. Chem. 64:1398-1407 The mechanism of the hydrolysis of condensed phosphates. I. The sodium tripolyphosphate, solvent effect on the hydrolysis of Bulletin of the Chemical society of Japan. sodium pyrophosphate 0, ? 7758-29-4, ? Watanabe M 1974 pyro- and tripolyphosphates N/A 47(8): 2048-2050 primary mutagenicity screening of bacteria food additives currently used in salmonella sodium tripolyphosphate 0, 10 13573-18-7 Ishidate M. et al 1984 Japan (ames test) Fd. Chem. Toxic. 22(8): 623-636 Inorganic phosphates in biology:structure, metabolism and STPP, SHMP, IMP 0, 10 ,11 7758-29-4 Harold FM 1966 function, Bacteriological Reviews: 772-794. STPP, sodium hexametaphosphate, Enzymatic degradation and tetrapotassium Davis E.M. And Wilcomb assimilation of condensed pyrophosphate 0, 10, 15 7758-29-4 M.J. 1967 phosphates by green algae algae water res. 1: 335-350 STPP, sodium hexametaphosphate, condensed phosphate degradation tetrapotassium Davis E.M. And Wilcomb and assimilation by selected blue- pyrophosphate 0, 10, 15 7758-29-4 M.J. 1968 green algae algae water res. 2: 311-324 Effect of polyphosphates on chick Inst. Lanwirtsch. Zool. Bienenkd. 27(5): 237- STTP, SHMP, DSP 0, 10, 3 7758-29-4 Karb B. 1971 embryos chicks 251 0, 11, 10, Analytical chemistry of the condensed STPP 9, 7, 5 13573-18-7 Greenfield S 1975 First Edition, pp 1-202. n/a phosphates, Pergamon Press sodium tripolyphosphate, Berenson M.M. And Detergent toxicity: effects on dipotassium phosphate 0, 13 Temple A.R. 1975 Esophageal and gastric mucosa cats clin. Toxicology 8(4): 399-404

Analysis of Mixtures of the Condensed Phosphates by Ion- Exchange Chromatography; II. STPP, dipotassium Mixtures of Ortho-, Pyro-, Tri-, Tetra-, phosphate, tetrasodium 0, 13, Peters TV Jr and Rieman Trimeta-. And Tetrametaphosphates pyrophosphate, 7,11, 8, 9 7758-29-4 (III) Wm 1956 and Graham’s Salt. N/A Analytical Chimica Acta, 14: 131-135

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

STPP, tripotassium phosphate, trisodium trimetaphosphate, Behavior of the condensed trisodium hydrogen Beukenkamp J., Rieman phosphates in anion-exchange diphosphate 0, 14, 8, 6 7758-29-4 W. and Lindenbaum S. 1954 chromatograpy. n/a Anal. Chem. 26, 3:505-512 Factor Interactions and their STPP, tetrapotassium Hons FM, Steward WM Influence on Hydrolysis of pyrophosphate 0, 15 7758-29-4 and Hossner LR. 1986 Condensed Phosphates in Soils Soil Soil Science: 408-416.

Kinetics of pyro- and sodium tripolyphosphate, tripolyphosphates hydrolyses in the tetrapotassium presence of corn and soybean roots pyrophosphate 0, 15 7758-29-4 Subbarao Y.V. Et al 1977 as determined by NMR spectography roots soil sci soc amer 41: 316-318 sodium tripolyphosphate, tetrapotassium Weaver J.E. And Griffith induction of emesis by detergent Toxicology and applied pharmacology 14: 214- pyrophosphate 0, 15 7320-34-5 J.F. 1969 ingredients and formulations dogs 220 sodium tripolyphosphate, monosodium phosphate, Comparison of Various Phosphate potassium Salts as the Dietary Phosphorus dihydrogenphosphate, 0, 2, 12, Source on Nephrocalcinosis and potassium tripolyphosphate 16 7778-77-0 Matsuzaki H. et al 1999 Kidney Function in Rats Rats J Nutr Sci Vitaminol 45: 595-608 sodium tripolyphosphate, Inorganic alkalizers and acidifier monosodium phosphate, under conditions of high urinary Na+ trisodium phosphate, or K+ on cell proliferation potassium and two-stage carcinogenesis in the dihydrogenphosphate 0, 2, 4, 12 7558-80-7 Shibata M.A. Et al 1992 rat bladder Rats Jpn. J. Cancer res. 83: 821-829 sodium tripolyphosphate, comparative promoting activities of monosodium phosphate, phosphate salts on rats two-stage trisodium phosphate, bladder carcinogenesis under potassium conditions of equivalent urinary Na+ teratogenesis, Carciogenesis and Mutagenesis dihydrogenphosphate 0, 2, 4, 12 7558-80-7 Shibata M.A. Et al 1991 or K+ levels Rats 11: 305-316 STPP, monosodium phosphate, trisodium Triphosphate, the key structure of the phosphate, sodium acid ATP molecule responsible for pyrophosphate 0, 2, 4, 5 7758-29-4 Bo X., Burnstock G. 1993 interaction with P2x-purinoreceptors rats Gen. Pharmac. 24(3) 637-640

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium tripolyphosphate, Hydrolysis and Sorption Reactions of sodium orthophosphate, Orthophosphate, Pyrophosphate, trisodium hydrogen Tripolyphosphate, and diphosphate, trisodium 0, 2, 4, 5, Blanchar R.W., Hossner Trimetaphosphate Anions Added to trimetaphosphate 6, 8 7558-80-7 L.R. 1969 an Elliot Soil soil soil sci soc amer proc 33: 141-144 sodium tripolyphosphate, sodium orthophosphate, trisodium hydrogen Hydrolysis and sorption of ortho-, diphosphate, trisodium 0, 2, 4, 5, Blanchar R.W., Hossner pyro-, tripoly- and trimetaphosphate trimetaphosphate 6, 8 7558-80-7 L.R. 1969 in 32 midwestern soils soil soil sci soc amer proc 33: 622-625 sodium tripolyphosphate, sodium orthophosphate, trisodium phosphate, Rangia cuneata tetrasodium Effects of phosphates on shell growth (marine) and pyrophosphate, sodium 0, 2, 4, 7, Bernhardt, A.M., Kunigelis and calcium carbonate crystal Helisoma duryi hexametaphosphate 10 7558-80-7 S.C., Wilbur K.M. 1985 formation (freshwater) Aquatic Toxicology, 7, 1-13 Editha Karl-Krouper, Clayton F. Callis & Eli stability of condensed phosphates in Industrial and Engineering Chemistry. Vol. 49, STPP, MSP, SAPP 0, 2, 5 7758-29-4 Seifter 1957 very dilute solutions. n/a no. 12, p2061-2062 The influence of rearing temperatures on the toxicity of various STPP, MSP, SAPP, 0, 2, 5, environmental pollutants for Killifish sodium tetrapolyphosphate (4?) 7758-29-4 Tsuji S. et al 1986 (Oryzias latipes) fish J Hyg Chem esei Kagaku 32(1): 46-53 Inhibitory effects of laundry detergents on the growth of STPP 0, 2, 5, 13 7758-29-4 Yamane A.N. Et al 1984 freshwater algae algae Suishitsu Odaku Kenkyu 7(9):576-582 sodium tripolyphosphate, sodium orthophosphate, sodium acid pyrophosphate, trisodium trimetaphosphate, sodium 0, 2, 5, 8, the effects of phosphate structure on metaphosphate 9 7558-80-7 Harris R.S. Et al 1967 dental caries development in rats Rats J. D. Res. 46(1): 290-294 sodium tripolyphosphate, sodium phosphate, sodium Different Compatibility of acid pyrophosphate, 0, 2, 5, 9, orthophosphates and polyphosphates graham's salt 11 231-449-2 Hahn f, Jacobi H, Seifen E 1958 in chronic feeding tests? rats Arneimittel-forschung 8():286

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium tripolyphosphate, sodium orthophosphate, trisodium hydrogen diphosphate, tetrasodium pyrophosphate, trisodium trimetaphosphate, sodium 0, 2, 6, 7, hydrolysis of dehydrated sodium hexametaphosphate 8, 10 7558-80-7 Bell R.N. 1947 phosphates soil ind eng chem 39: 136-140 sodium tripolyphosphate, monosodium orthophosphate, tetrasodium The effects of inorganic phosphates pyrophoshpate, sodium Kunigelis S.C. And Wilbur on trochopore larvae of the oyster hexametaphosphate 0, 2, 7, 9 7558-80-7 K.M. 1987 crassostrea virginica oyster larvae int J invert repro and develop 12: 161-172

a comparative study of the cariostatic sodium tripolyphosphate, effect of dietary fluorides, sodium orthophosphate, Muhlemann H.R. And orthophosphates and triphosphates trisodium trimetaphosphate 0, 2, 8 7558-80-7 Konig K.G. 1967 in osborne-mendel rats Rats helv odontol acta 8(1): 56 INTERNATIONAL PROGRAMME ON 0, CHEMICAL SAFETY 2,3,4,5,7, WORLD HEALTH 9,10,11,1 ORGANIZATION STPP, MSP, DSP, TSP, 2,13,14,1 TOXICOLOGICAL INTERNATIONAL PROGRAMME ON SAPP, TSPP, SMP, SHMP, 5,16,19,2 EVALUATION OF CHEMICAL SAFETY WORLD HEALTH IMP, MKP, DKP, TKP, 0,21,22,2 CERTAIN VETERINARY ORGANIZATION TOXICOLOGICAL TKPP, KTPP, DAP, APP, 4,26,29,3 DRUG RESIDUES IN EVALUATION OF CERTAIN VETERINARY MCP, DCP, TCP/HAP, 0,31,46,4 FOOD WHO FOOD DRUG RESIDUES IN FOOD WHO FOOD CPP, DMP, TMP, MMP, PA 8 N/A ADDITIVES SERIES 17. 1982 Review: Toxicity ADDITIVES SERIES 17.

Integrated Pollution Prevention and Control: Reference Document on Best Available Techniques for the Manufacture of Large Volume Inorganic Risk Assessment guidance on Chemicals - Solids and 2006 - prevention of pollution from ECB.JRC ftp://ftp.jrc.es/pub/eippcb/doc/ [Draft STPP, MCP, DCP 0, 21, 22 7758-29-4 Others industry. Aug manufacture and use ? BREF for LVIC-S products (2005)]

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Range Finding Toxicity Data: List VII. Acute Toxicity and irritation data on about 200 compounds are presented, STPP, disodium accumulated in a continuing program phosphate, trisodium for screening potential commercial American Industrial Hygiene Association phosphate 0, 3, 4 7758-29-4 Smyth HF et al (1969) 1969 products. Rat Journal, 470-476 sodium tripolyphosphate, trisodium phosphate, Microbiological Quality of Catfish sodium Frames Treated with Selected hexametaphosphate 0, 4, 10 7601-54-9 Marshall D.L., Jindal V. 1997 Phosphates fish j. of food protection 60(9): 1081-1083 Review.Technical, occupational health and environmental aspect of metal degreasing with aqueous STPP, TSP, TKPP 0, 4, 15 7758-29-4 Lavoue et al 2003 cleaner. N/A Annual occupational hygiene.47.441-459 sodium tripolyphosphate, trisodium phosphate, tetrasodium pyrophosphate, trisodium Enzymic hydrolysis of trimetaphosphate, sodium 0, 4, 7, 8, polyphosphates in the hexametaphosphate 10 7785-84-4 Ivey J., Shaver K. 1977 gastrointestinal tract rats J. Agric. Food Chem. 25(1): 128-130

STPP, pyrophophosphoric acid, magnesium hydrogen orthophosphate, tricalcium phosphate, monocalcium phosphate, potassium metaphosphate, pentapotassium triphosphate, monopotassium European Parliament and Council phosphate, trisodium 0, 45, 29, Directive No 95/2/EC of 20th phosphate, disodium 24, 21, February 1995 on food additives phosphate, monosodium 17, 16, other than colours and sweeteners phosphate 12, 4, 3, 2 7758-29-4 Anon 1995 (OJ L 61, 18.3.1995, p.1). N/A (OJ L 61, 18.3.1995, p.1).

Dr. Werner Kastner et Dr Toxicity via oral, sub-cutaneous, rats, mice, Toxicite et ecotoxicite des produits de STPP, PA 0, 48 7758-29-4 Peter GODE, Henkel KGaA 1983 cutaneous, intraperitoneal routes rabbits traitement des eaux

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Ramel C. and Magnusson chemical induction of nondisjunction drosophila STPP, phosphoric acid 0, 48 7758-29-4 J. 1979 in Drosophilia melanogaster Environmental Health perspective 31: 59-66 Effects of temperature and phosphate concentration on rate of sodium tripolyphosphate, sodium pyrophosphate and STPP Sodium pyrophosphate 0, 5 7758-16-9 Chang C. and Racz G.J. 1977 hydrolysis in soil soils can J soil science 57: 271-278 sodium tripolyphosphate, sodium acid Hydrolysis of condensed phosphates pyrophosphate 0, 5 7758-16-9 Clesceri N.L. And Lee G.F. 1965 – II: sterile environment water int. J. air Wat. Poll. 9: 743-751 sodium tripolyphosphate, Crowther J.P. And the hydrolysis of the condensed Sodium pyrophosphate 0, 5 7758-16-9 Westman A.E.R. 1954 phosphates water can j chem 32: 42-48 The Influence of Chain Length on Gosselin RE and Megirian The Metabolic Fate of Condensed STPP, SAPP 0, 5 7758-29-4 R 1955 Phosphates Rat and Rabbit J Pharm Exp.Ther. 114: 402-407 Hydrolysis of condensed phosphates Internat. Assoc. Great Lakes Res., Proc. 12th STPP, SAPP 0, 5 7758-29-4 Heinke GW 1969 in Great Lakes Waters water Conf:766-773 Independence in hydrolysis of STPP, SAPP 0, 5 7758-29-4 Smith M.J. 1959 condensed phosphates water Can. J. Chem., 37: 1115-1116 Gosselin RE et al Clinical toxicity of commerical Clinical Toxicology of Commercial Products. STPP, SAPP 0, 5 7758-29-4 1984 products 5th Ed.11-121 sodium tripolyphosphate, hydrolysis of sodium pyrophosphate sodium pyrophosphate 0, 5 7758-16-9 Savant N.K. And Racz G.J. 1972 and STPP by plant roots seeds soil science 113(1): 18-22 sodium tripolyphosphate, sodium acid pyrophosphate, sodium hexametaphosphate, 0, 5, 10, Heat-Sensitization of Salmonella by calcium trimetaphosphate n/a 7758-29-4 Seward R.A. Et al 1986 Polyphosphates bacteria J. of food science 51(2): 471-473 sodium tripolyphosphate, sodium pyrophosphate, tripolyphosphate and pyrophosphate tripotassium phosphate 0, 5, 14 7758-16-9 Blanchar R.W., riego D. 1976 hydrolysis in sediments sediments soil sci soc amer proc 40: 225-229

STPP, sodium acid pyrophosphate, tetrasodium pyrophosphate, 0, 5, 7 , Hydrolysis of condensed phosphates monopotassium phosphate 12 7758-29-4 Clesceri N.L. And Lee G.F. 1965 – I: non-sterile environment water int. J. air Wat. Poll. 9: 723-742

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Various 0, 5, 7, 8, 19, 18, 16, 46, 15, 14, Kirk-Othmer Encyclopaedia of Chemical 13, 12, Technology. 17, 20, 4, phosphoric acid and phosphates Kirk-Othmar 3, 2 Various Gard 2001 Phosphoric Acids and Phosphates. n/a encyclopedia 2001 sodium tripolyphosphate, sodium acid pyrophosphate, tetrasodium pyrophosphate, trisodium trimetaphosphate, sodium metaphosphate, sodium hexametaphosphate, 0, 5, 7, 8, ABSTRACT: Studies on the CarbP 9, 10, 51 7758-16-9 Zipf. K.. 1957 toxicology of polyphosphates Mouse Arzneimittel 7(7) : 446-447 sodium tripolyphosphate, sodium acidpyrophosphate, tetrasodium Inhibitory effects of polyphosphates pyrophosphate, sodium on Clostridium perfringens growth, polyphosphate glassy 0, 5, 7, 9 7758-16-9 Akhtar S. et al 2008 sporulation and spore outgrowth fungus Food Microbiology 25: 802– 808 sodium tripolyphosphate, sodium Effect of Poly- and Pyrophosphates acidpyrophosphate, on the natural Bacteria Flora and tetrasodium inoculated Clostridium sporogenes pyrophosphate, sodium PA 3679 in cooked packaged polyphosphate glassy 0, 5, 7, 9 7758-16-9 Molins R.A. Et al 1985 Bratwurst bacteria J of foof science 50: 876-880 STPP, SAPP, STMP, Reversion of molecularly dehydrated Industrial & Engineering Chemistry, 42 (8): SHMP 0, 5, 8, 10 7758-29-4 Green J 1950 sodium phosphates. n/a 1542-1546 Review of Epidemiological Social Medicine and Public Health. (Toxicité Aiguë Des Chélatant 0, 5, 8, Acute Toxicity: Therapeutic Thérapeutiques Utilisables Dans L’Industrie 10, 11 Chelatants of Use in Nuclear Nucléaire. Revue d’Epidemiologie Medecine STPP 7758-29-4 Chadiot P and Lafuma J 1962 Industry. mice Sociale et Santé Publique.

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

STPP, sodium acid pyrophosphate, trisodium trimetaphosphate, sodium metabolic acidosis and hypocalcemia metaphosphate / 0, 5, 8, as toxic manifestations of polymeric Journal of Pharmacology and Experimental hexametaphosphate 9/10 7758-29-4 Gosselin R.E. Et al 1952 phosphates rats Therapeutics. 117-127. sodium tripolyphosphate, sodium pyrophosphate, Hahn f, Jacobi h, Rummel ABSTRACT: chronic feeding sodium metaphosphate 0, 5, 9 7758-16-9 W. 1956 experiments with polyphosphates Rats Die Naturwissenchaften 43(23): 539-540 Structure and properties of the condensed phosphates. VII. Van Wazer JR, Griffith EJ Hydrolytic degradation of pyro- and STPP, TSPP 0, 7 7758-29-4 and McCullough JF 1955 tripolyphosphate N/A J. Am. Chem. Soc., 77: 287-291

sodium tripolyphosphate, The mechanism of the hydrolysis of sodium pyrophosphate, condensed phosphates. IV. The sodium trimetaphosphate, 7758-29-4, hydrolysis of pyro-, tripoly-, trimeta- sodium 0, 7(or 5), 7722-88-5, Watanable M, Sato S and and tetrametaphosphates in aqueous Bulletin of the Chemical Society of Japan. tetrametaphosphate 8 7785-84-4 Saito H 1976 organic solvents N/A 49(9): 2474-2478 0, 7, 11, Irani R.R. and Iron sequestration by STPP 28 7758-29-4 Morgenthaler W.W. 1963 polyphosphates. n/a J. Am. Oil Chem. Soc. 40:283-285 STPP, TSPP, STMP, Hydrolysis rates of inorganic sodium acid polyphosphates in aqueous solution pyrophosphate, disodium 0, 7, 8, 5, as well as in soils and effects on P phosphate 3 7758-29-4 Torres-Dorante L.O. Et al 2005 availability water and soil J plant nutr soil sci 168: 352-358 sodium tripolyphosphate, tetrasodium diphosphate, sodium polyphosphate Fingerhut F., Ruf F., Lang (65% P2O5) 0, 7, 9 7722-88-5 K. 1965 resorption of the polyphosphates rats klin wochensch 43: 956-957 sodium tripolyphosphate, Tetrasodium pyrophosphate, Graham's salt, sodium 0, 7, 9, Metabolism of different activated pentapolyphosphate n/a 231-767-1 Schreier K. and Noller H.G. 1955 polyphosphates Rats Arch. Exper. Path. U Pharmakol. 227: 199-209 STPP, trisodium Dick R.P. And Tabatabai Hydrolysis of polyphosphates by corn trimetaphosphate 0, 8 7758-29-4 M.A. 1986 roots corn Plant and soil 94: 247-256 sodium tripolyphosphate, the hydrolysis and excretion of sodium trimetaphosphate 0, 8 7785-84-4 Gosselin R.E. Et al 1952 polymeric phosphate Rats ??: 180-192

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

tripolyphosphate and sodium tripolyphosphate, trimetaphosphate in yeast sodium trimetaphosphate 0, 8 7785-84-4 Kornberg S.R. 1955 ABSTRACTs yeast Jourma; of biological cheistry STPP, STMP, TSP, sodium dihydrogen orthophosphate, sodium phosphate-glass, sodium 0, 8, 4, 2, effects of condensed phosphates on ultraphosphate 9, n/a 7758-29-4 El-Reweiny F.M. et al 1976 plant growth and phosphorus uptake grass Plant and soil 44: 1-14 sodium tripolyphosphate, sodium metaphosphate, sodium action of phosphates on experimental hexametaphosphate 0, 9, 10 68915-31-1 Cardenas J. et al 1960 tumors Rats and mice Acta pharmacol. Et toxicol. 17: 157-160 sodium tripolyphosphate, experimental substantiation of sodium metaphosphate, hygienic standardization of sodium sodium Perova N.M.and Sergeev hexametaphopshate and hexametaphopshate 0, 9, 10 68915-31-1 A.N. 1973 tripolyphosphate in drinking water water gisaaa gigiena i sanitariya 38(9): 19-22 Dick R.P. And Tabatabai STPP, SMP, SAPP, STMP 0, 9, 5, 8 7758-29-4 M.A. 1986 Hydrolysis of polyphosphates in soil soil soil science 142(3): 132-140 Dick R.P. And Tabatabai Factors affecting hydrolysis of STPP, SMP, SAPP, STMP 0, 9, 5, 8 7758-29-4 M.A. 1987 polyphosphates in soils soils soil science 143(2): 97-104

0,2,3,4,5, 7,10, calcium 0,2,3,4,5,7,10, calcium acid acid phosphate phosphate 7758-29-4 Tompkin RB 1983 Microbial effects of phosphates microbes Journal of food safety. 6:13-27 0,2,3,4,5, 7,12,13,1 STPP, MSP, DSP, TSP, 4,15,16,1 SAPP, TSPP, MKP, DKP, 8,19,20,2 TKP, TKPP, KTPP, DAP, 1,22,24,2 APP, MCP, DCP, TCP, 6,29,30,3 CPP, DMP, TMP, MMP, 1,39,44,4 Ullmann's Encyclopedia of Industrial MALP, BOP, SFP, PA, 7,48,49,5 Chemistry, Author's Edition Phosphoric acid PPA, PyroPA 0 N/A Schrödter K et al 2007 physiochemical properties (pg 23) n/a and Phosphates

STPP and tetrasodium Elliot P, Straka RP and Polyphosphate inhibition of growth of pyrophosphate 0,7 7758-29-4 Garibaldi JA 1964 Pseudomonads from poultry meat. Bacteria Applied microbiology.12(6):517-522

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium hexametaphosphate, Influence of phosphate compunds on sodium tripolyphosphate, certain fungi and their preservative sodium tetraphosphate and Post FJ, Coblentz WS, effects on fresh cherry fruit (Prunus terasodium pyrophosphate. 10, 0, 7 10124-96-8 Chou TW & Salunkhe DK 1968 cerasus, L.) fungi Applied microbiology. 16(1): 138-142 sodium Steinhardt Bour NJ et al hexqametaphosphate, Effect of level and form of monopotassium phosphorous and level of calcium phosphate, dipotassium intake on Zinc, Iron and Copper phosphate, 10, 12, 13 68915-31-1 1984 bioavailability in man. man Nutrition Research, 4:371-379 sodium hexametaphosphate, effect of normal and high Intakes of dibasic potassium Dymsza H.A., Reussner Orthophosphates and phosphate 10, 13 68915-31-1 G.Jr, Thiessen Jr 1959 metaphosphates in Rats rats j. Nutrition 69: 419-428 sodium K. G. König, Th. M. hexametaphosphate, Marthaler & H. R. sodium acid Mühlemann pyrophosphate, disodium phosphate 10, 5, 3 10124-56-8 1961 rat sodium Batra S.C. hexametaphosphate, sodium acid pyrophosphate, trisodium The ionisation behaviour of some phosphate, disodium 10, 5, 4, poly (meta) phosphates used in food phosphate, STPP 3, 0 10124-56-9 1965 products. n/a J. Food Sci. 30:441-444 sodium FDA - Dietary Supplements [Reserved] hexametaphosphate, Subpart G - Sequestrants, 461. tetrasodium pyrophosphate, sodium acid pyrophosphate, disodium phosphate 10, 7, 5, 3 10124-56-10 Food and Drug Administration, HHS Subpart F Sodium hexametaphosphate and ABSTRACT: mechanisms calcium responsible for the acute toxicity of a hexametaphosphate 10, 9 10124-56-11 Tibdall C.S. et al 1952 phosphate glass Rats fed proc 11(1): 162 sodium metaphosphate Inorganic Chemistry 1. The insoluble, sodium metaphosphates and polyphosphates Ann Reports Progr Chem, 34 (SUPPL: ref hexametaphosphate 11, 10 10361-03-2 Terrey H. 1937 of sodium. n/a topley): 115-122

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Structure and properties of the sodium metaphosphate condensed phosphates. III. Solubility insoluble, sodium fractionation and other solubility hexametaphosphate 11, 10 10361-03-2 Van Wazer J R 1950 studies. J Amer. Chem. Soc. 72: 647 - 655. CIR Epxert Panel (2001), Final Report on the Safety sodium metaphosphate Assessment of Sodium insoluble, sodium Metaphosphate, Sodium hexametaphosphate, Trimetaphosphate and Sodium International Journal of Toxicology, 20(Suppl. trisodium trimetaphosphate 11, 10, 8 10361-03-2 Hexametaphosphate, 3):75-89; sodium metaphosphate insoluble, monosodium Zinc, Iron and Copper Availability as phosphate, disodium Zemel MB and Bidari M Affected by Orthophosphates, phosphate, 11, 2, 3 10361-03-2 1983 Polyphosphates and Calcium. rat Journal of Food Science, 48: 567-571 mobilisation of heavy metals from monopotassium river sediments of northern Greece phosphate, STPP 12, 0 7778-77-0 Samanidou V. 1990 by complexing agents rivers Water, air and soil pollution 52: 217-225 potassium dihydrogenphosphate, Infidelity of DNA synthesis in vitro: dipotassium screening for potential metal hydrogenorthophosphate 12, 13 7778-77-0 Sirova MA and Loeb LA 1976 mutagens or carcinogens Science. 194(4272): 1432-1436 monopotassium phosphate, dipotassium Influence of inorganic phosphates on phosphate 12, 13 7778-77-0 Torriani A 1960 enzyme formation in E.coli Bacteria Biochem. Biophys. Acta, 38:460-479 monopotassium phosphate, dipotassium phosphate, monosodium Effect of phosphates on phophatase phosphate, disodium 12, 13, 2, Kalashnikova NA & synthesis by the culture Aspergillus phosphate 3 7778-77-0 Rodenvich 1970 awamori strain 22 n./a Prikl Biokhim Mikrobiol. 6: 516-519

Greater effect of dietary potassium tripolyphosphate than of potassium potassium dihydrogenophosphate on the dihydrogenphosphate nephrocalcinosis and proximal (KH2PO4), potassium tubular function in female rats from tripolyphosphate 12, 16 7778-77-0 Matsuzaki H. et al 2001 the intake of a high-phosphorus diet rats Biosci. Biotechnol. Biochem 65(4): 928-934

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Potassium dihydrogen orthophosphate, Sodium and potassium pyrophosphate, Potassium triphosphate, Potassium trimetaphosphate Activity Coefficients of Some 12, 16 7778-77-0 Miller G and Porter AS 1967 Polyphosphates in Aqueous Solution. N/A Trans Faraday Soc, 63: 335-340 monopotassium phosphate, monoammonium 7778-77-0, Das quaternare system K2O-NH3- phosphate 12, 18 7726-86-1 Janecke E 1927 P2O5-H2O bei 0° und 25° N/A Z Physik Chem. 127:71-92 Thilo E. potassium dihydrogen orthophosphate, disodium Zur Chemie der kondensierten dihydrogenorthophosphate 12, 2 7778-77-0 1956 Phosphate. Chem. Technol., 8:251-270 Silverberg SJ et al The Effect of Oral Phosphate Administration on Major Indices of monopotassium phosphate Skeletal Metabolism in Normal Journal of Bone and Mineral Research, 1(4): , monosodium phosphate 12, 2 7778-77-0 1986 Subjects. human 383-388 Griffith EJ, A nomograph for the hydrolytic monopotassium phosphate degradation of pyrophosphates and , monosodium phosphate 12, 2 7778-77-0 1959 tripolyphosphates, Industrial and Engineering Chemistry, 51: 240. potassium dihydrogen Effect of phosphate supplements on phosphate and disodium Jowsey J and soft-tissue calcification and bone hydrogen phosphate 12, 2 7778-77-0 Balasubramaniam P 1972 turnover. Clinical Science. 42: 289-299 monopotassium phosphate, disodium pyrophosphate, sodium tripolyphosphate, (NH4)6P4O13 (Hexa- ammonium tetraphosphate), Sodium Methods for Differentiated phosphate Glass Type, 5, Determination of Orthophsophate, 15, 25, 35, 45, 65, 75 Mussig-Zufica VM and Condensed Phosphates and 12, 2, 0 7778-77-0 Jekel M 1992 Polyphosphate N/A Z Wasser-Abwasser-Forsch, 25: 353-356

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Effect of dietary Ca and Cd level of pregnant rats on reproduction and on potasium phosphate, Pond W.G. And Walker Dam and progeny tissue Mineral Proceedings of the soc. For exp. Biology and dicalcium phosphate 12, 22 7757-93-9 E.F. 1975 concentration (38606) Rats medicine 148: 665-668 effect of dietary Ca and P levels from monopotassium 40 to 100 kg bodyweight on weight phosphate, dicalcium Pond WG, Walker EF and gain and soft tissue mineral phosphate 12, 22 7778-77-0 Kirtland D 1978 concentrations. Pigs Journal of animal science. 46(3): 686-691 dipotassium phosphate, Garen A and Levinthal C A Fine-Structure Genetic and sodium acid Chemical Study of the Enzyme pyrophosphate 12, 5 7757-93-9 1960 Alkaline Phosphatase of E.coli. E.coli unknown

Dipotassium phosphate, monocalcium phosphate, 7758-11-4, dicalcium phosphate, 7758-23-8, copper (II)- 7757-93-9, Structure de l'ion PO43- dans hydroxyphosphate, 13, 21, 12158-74-6, l'anhydride phosphorique et les tetrasodium pyrophosphate 22, 38, 7 7722-88-5 Duc-Maugé C 1959 phosphates métalliques N/A Bull Soc Chem France: 1032-1042 Schneider P, Ober KM and Contribution to the phosphate- Uerberberg H induced nephropathy in the dog. Comparative light and electron microscopic investigations on the proximal tubule after oral application dipotassium phosphate, of K2HPO4, Na2HPO4, KCl and disodium phosphate 13, 3 7758-11-4 1981 NaCl. Experimental pathology 19: 53-65 Lehman JT Ecological and nutritional studies on Dinobryon Ehrenb.: Seasonal dipotassium phosphate, periodicity and the phosphate toxicity disodium phosphate 13, 3 7758-11-4 1976 problem. dinobryon Limnology and Oceanography, 21(5): 646-658

Stream Pollution, Toxicity to Gambusia affinis of certain pure TKP, MSP, SAPP 14, 2, 5 7778-53-2 Wallen IE et al 1957 chemmicals in turbid water. fish Sewage and industrial wastes, 29(6): 695-711 potassium pyrophosphate, Hydrolysis and uptake of pyrophosphoric acid 15, 50 7320-34-5 Gilliam J.W. 1970 pyrophosphate by plant roots plants soil sci soc amer proc 34: 83-86

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monoammonium phosphate, tripotassium phosphate, disodium Ammonium dihydrogen phosphate prepared at phosphate, monosodium 18, 14, 3, Phosphoric acid prepared at the 59th the 27th JECFA (1983) published in 1983 and phosphate 2 7722-76-1 JECFA 59th 2002 JECFA n/a 1992. Revised at the 59th JECFA (2002). monoammonium phosphate, diammonium 7722-76-1, Ross WH, Mertz AR & Preparation and properties of the Industrial and Engieneering chemistry. 21(3): phosphate 18, 19 7783-28-0 Jacob KD 1929 ammonium phosphates n/a 286-288 monoammonium Fazekas IG Fazekas IG (1954) Vergößerung der Nebenschilddrüsen? durch einfach acidotische Verbindungen. Enlargement of parathyroid glands by simple acidic compounds. phosphate, disodium phosphate 18, 2 7722-76-1 1954 Virchows Archiv 324: 531-542 19, 18, 16, 15, 14, 13, [13, 11, 10, 7, 5, 3, 2], 12, 10, 5 8, Furia T E Various 5, 4, 3, 2 various 1972 Handbook of Food Additives N/A Handbook of food additives.CRC

reaction products of polyphosphates diammonium and orthophosphates with soils and orthophosphate, 7783-28-0, influence on uptake of phosphorus by ammonium polyphosphate 19, 20 14728-39-3 Subbarao Y.V. And Ellis R. 1975 plants soil soil sci soc amer proc. 39: 1085-1088 Chemical forest fire retardants: acute diammonium phosphate, 7783-28-0, Johnson W.W., Sanders toxicity to five freshwater fishes and a ammonium polyphosphate 19, 20 14728-39-3 H.O. 1977 Scud fish and scud us fish wildlife serv tech pap 91: 1-8 diammonium reactions of ammonium ortho- and orthophosphate, 7783-28-0, polyphosphate fertilizer in soil: I ammonium polyphosphate 19, 20 14728-39-3 Khasawneh F.E. Et al 1974 Mobility of Phosphorus soils soil sci soc amer proc 38: 446-451 diammonium reactions of ammonium ortho- and orthophosphate, 7783-28-0, polyphosphate fertilizer in soil: II ammonium polyphosphate 19, 20 14728-39-3 Khasawneh F.E. Et al 1979 Hydrolysis and reactions with soil soil soil sci soc amer proc 43: 52-58 Sutton C.D., Gunary D. and diammonium Larsen S. Pyrophosphate as a source of orthophosphate, 7783-28-0, phosphorus for plants II. Hydrolysis ammonium polyphosphate 19, 20 14728-39-3 1966 and initial uptake by a barley crop. Soil Sci., 101(): 199-204

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium phosphate, lead Lead poisoning. Newer concepts in New York State Journal of Medicine. 38(20): phosphate 2 (?) 7558-80-7 Gray I and Greenfield I 1938 treatment. human 1313-1319 Ritskes-Hoitinga J., sodium dihydrogen Lemmens A.G. And Nutrition and kidney calcification in phosphate 2, 7558-80-7 Beynen A.C. 1989 rats Rats Laboratory animals 23: 313-318 A clinical study concerning the anticariogenic effects of NaH2PO4- Anhydrous sodium enriched breakfast cereals in dihydrogen orthophosphate institutionalized subjects: results after NaH2PO4 2, (3) 7558-80-7 Brewer H.E. Et al 1970 two years human J. Amer. Dent. Assoc. 80: 121-124 monosodium phosphate Lorenz B et al Purification and Characterization of (MSP), sodium an Exopolyphosphatase from The Journal of Biological Chemistry 269(35): tripolyphosphate (STPP) 2, 0 7558-80-7 1994 Saccharomyces cerevisiae. n/a 22198-22204. sodium phosphate, sodium The effect of the complex-forming hexametaphosphate, Borenstein M.K. And amorphous sodium phosphates on monosodium phosphate 2, 10, 8 7558-80-7 Schwartz C. 1948 the calcium retention of rats Rats J Nutr. 36: 681-694

Anhydrous sodium dihydrogen orthophosphate NaH2PO4, monopotassium Effect of phosphate and pH on phosphate, dipotassium Handelman S.L., Kreinces Streptococcus mutans acid phosphate 2, 12, 13 7558-80-7 G.H. 1972 production and growth bacteria J. Dent. Res. 52(4): 651-657 Mode of Action of Pharmacological monosodium phosphate, Doses of Cholecalciferol during monoammonium Parturient Hypocalcemla In Dairy phosphate 2, 18 7558-80-7 Reinhardt TA & Conrad HR 1980 Cow. cows J Nutr. 110:1589-1596

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Sodium dihydrogen phosphate, Calcium sodium magnesium phosphate, Calcium hydrogenorthophosphate/C alcium dihydrogenorthophosphate, Calcium bis(dihydrogenorthophosph Investigations on the availability of ate), Calcium-sodium- inorganic phosphate from different phosphate 2, 21, sources with growing white Pekin 22,23 7558-80-7 Wendt P et al 2004 ducks Pekin duck Poult. Sci. (2004) 83:1572-1579. monosodium phosphate, effect of sodium phosphate on basal disodium phosphate 2, 3 7558-80-7 Abelin. J. Kobori. B 1927 metabolism rats Biochem Z., 180():211-217 sodium phosphate monobasic, sodium phosphate dibasic 2, 3 7558-80-7 Haut L.L. Et al 1980 Renal toxicity of phosphate in rats rats Kidney international 17: 722-731 monosodium phosphate ABSTRACT: The clinical effect of (75% of the mixture), phosphate-enriched breakfast cereals disodium phosphate (25% on dental care incidence in adolscent of mixture) 2, 3 7558-80-7 Rowe N.H. Et al 1974 children human J. D. Res spec issue, 53: 605

ABSTRACT: North Dakota field test sodium dihydrogen of cariostatic effect of 1% sodium phosphate, disodium dihydrogen phosphate and disodium phosphate, trisodium hydrogen phosphate added to trimetaphosphate 2, 3, 0 7558-80-7 Peterson J.K. 1969 presweetened breakfast cereals human J. D. Res. 1308 monosodium phosphate, The Pharmacological basis of therapeutics. 9th disodium phosphate, The Pharmacological basis of Edn. calcium phosphate 2, 3, 21 7558-80-7 Goodman and Gliman 1996 therapeutics Goodman & Gilmans sodium dihydrogen orthophosphate, disodium renal damage following the ingestion phosphate, trisodium of a diet containing an excess of phosphate, phosphoric acid 2, 3, 4, 48 7558-80-7 MacKay E.M. And Olivier J. 1935 inorganic phosphate rats j. exp. Med. 61: 319

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium dihydrogenorthophosphate, disodium hydrogenorthophosphate, 7558-80-7, trisodium orthophosphate, 7558-79-4, tetrasodium 7601-54-9, Viscometric studies of solutions of pyrophosphate, sodium 7722-88-5 sodium phosphates, graham salts tripolyphosphate, sodium 2, 3, 4, 7, 7758-29-4, Nakagaki M, Ohashi S and and vanadium-containing graham Viscosities of sodium phosphates and polyphosphate 0, 9 68915-31-1, Minato F 1963 salt N/A grahams salts. 36(3) monosodium phosphate, disodium phosphate, Toxicity of phosphates, in relation to Journal of Pharmacology and Experimental phosphoric acid 2, 3, 48 7558-80-7 Binger C 1918 blood calcium and tetany dog Therapeutics. 10:105

Complex sodium phosphate and trisodium phosphate included in the In vitro methods for estimating eye light duty liquid cleaner and irritancy of cleaning products phase I: granular laundry detergent 2, 4 7558-80-7 Booman KA et al 1988 Preliminary assessment rabbit eye N/A monosodium phosphate, Potential biological hazards of trisodium phosphate commercially available cleansers for Journal of Toxicology and Environmental 2, 4 7558-80-7 Osterburg RE 1977 dentures. N/A Health, 3: 969-977 disodium phosphate, sodium pyrophosphate 2, 5 7558-80-7 Datta P.K. Et al 1962 Biological effects of food additives rats Sci. Food Agric. 13: 556-566 sodium dihydrogenorthophosphate, sodium acid 7558-80-7, pyrophosphate 2, 5 7758-16-9 Morley GW 1953 The system H2O-NaPO3 N/A J Am Chem Soc 75:5794-5797 sodium phosphate, sodium Further tests on the tolerability of acid pyrophosphate, 2, 5, 9, phosphates following chronic graham's salt 11 231-449-2 Hahn F, Seifen E 1959 application rats Arneimittel-forschung 9():501 monosodium phosphate, sodium acid pyrophosphate, tetrasodium Inhibition of Asperigillus flavus and pyrophosphate, sodium selected Gram-positive bacteria by hexametaphosphate and Knabel SJ, Walker HW & chelation of essential metal cations sodium tripolyphosphate 2, 5, 7 7558-80-7 Hartman PA 1991 by polyphosphates. Bacteria JOURNAL OF FOOD PROTECTION, 54

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium phosphate monobasic, sodium acid pyrophosphate, tetrasodium pyrophosphate, sodium polyphosphate, sodium metaphosphate, potassium metaphosphate, calcium phosphate, monobasic, calcium phosphate dibasic, 2, 5, 7, 9, ferric pyrophosphate, 10, 17, sodium 21, 22, Data book of chromosomal aberration test in monoflurophosphate 28, 47 7558-80-7 Ishidate M, Sofuni T. 1988 chromosomal aberration test in vitro In vitro vitro sodium phosphate, monobasic, sodium acid pyrophosphate, potassium metaphosphate, sodium metaphosphate (different primary mutagenicity screening of bacteria CAS number to that 2, 5, n/a, food additives currently used in salmonella considered by IPC) 17 7558-80-7 Ishidate M. et al 1984 Japan (ames test) Fd. Chem. Toxic. 22(8): 623-636 sodium phosphate, monobasic, sodium acid pyrophosphate, potassium metaphosphate, sodium metaphosphate (different primary mutagenicity screening of CAS number to that 2, 5, n/a, food additives currently used in hamster considered by IPC) 17 7558-80-7 Ishidate M. et al 1984 Japan fibroblasts Fd. Chem. Toxic. 22(8): 623-636 sodium phosphate monobasic, sodium acid pyrophosphate, tetrasodium pyrophosphate, sodium polyphosphate, potassium metaphosphate, ferric 2, 6, 7, 9, pyrophosphate 17, 28 7558-80-8 Ishidate M. 1991 test on chemicals in bacteria bacteria data book of mutagenicity

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested disodium hydrogenphosphate, tetrasodiumpyrophosphate, 7558-79-4, Untersuchungen zum calcium- und sodium tripolyphosphate, 7722-88-5, Feldheim W and phosphorstoffwechsel beim grahams salt 2, 7, 0, 11 7758-29-4 Hesselbach C 1985 menschen. Minature pig Art Ernahr. 10. 30-33 monosodium phosphate, tetrasodium pyrophosphate, sodium hexametaphosphate, dipotassium phosphate, Toxicity and Teratogenicity of 80 food monocalcium phosphate, 2, 7, 10, additives chemicals in the developing Toxicology and applied pharmacology 56: 265- tricalcium phosphate 12, 21, 24 7778-77-0 Verret J. et al 1980 chicken embryo chicken embryo 273 ABSTRACT: effects on long- continued ingestion of sodium sodium orthophosphate, phosphate upon the parathyroid, sodium metaphosphate 2, 9 7558-80-7 Saxton J.A. And Ellis G.H. 1941 kidneys and bones of mature rats Rats am j path 17: 590 monosodium phosphate, sodium hexametaphosphate, anticoagulant boll soc ital biol sper 26 (chem abstr 45-8643): hexametaphosphate 2, 9 68915-31-1 Tria E. 1950 actin in vivo and in vitro dog 113 monosodium phosphate, disodium phosphate, Incidence of urinary calculi in sheep sodium tripolyphosphate, Bushman DH, Emerick RJ as affected by various dietary dicalcium phosphate 2,3,0,22 7558-80-7 & Embry LB 1965 phosphates sheep J Anim Sci 1965. 24:671-675. monosodium phosphate, Anderson BG The toxicity thresholds of various disodium phosphate, sodium salts determined by the use daphnia trisodium phosphate 2,3,4 7558-80-7 1946 of Daphnia magna. magna. Sewage works Journal. 18(1): 82-87 monosodium phosphate, disodium phosphate, trisodium phosphate, tetrasodium pyrophosphate 2,3,4,7 Starkenstein E 1911 Ionenwirkkung der Phosphorsauren ? Biochem Z. xxxii: 243-264 SIDS intial assessment SIDS intial assessment US ICCA SIAM phosphates 4-2007.pdf ammonium polyphosphate, profile.SIAM.24. profile.SIAM.24. monoammonium phosphate, diammonium 20, 18, phosphate 19, 68333-79-9 2007 rats, fish

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monocalcium phosphate effects of phosphate sources on the (hydrate), dipotassium mycelial growth of gigaspora Revista Brasileira de Ciencia do solo 156: 169- phosphate 21, 12 7758-23-8 Da silva L.R.C. Et al 1991 gigantea in vitro fungus 172 monocalcium phosphate, dipotassium Krook L, Lutwak L, hydrogenorthophosphate, Hnrikson P, Kallfelz F, Reversibility of Nutritional sodium Hirsch C, Romanus B, Osteoporosis: Physicochemical Data dihydrogenorthophosphate Belanger LF, Marier JR on Bones from an Experimental monohydrate 21, 12, 2 7758-23-8 and Shefft BE 1971 Study in Dogs dogs The journal of nutrition. 101:233-246 monocalcium phosphate, 46th JECFA. diammonium phosphate, sodium metaphosphate insoluble, sodium hexametaphosphate, 21, 19, Published in 1967, 1992 and 1996. Revised at sodium polyphosphate 11, 10, 9, 7758-23-8 1996 JECFA N/A the 26th JECFA 1982.

Correlation of biological value of feed dibasic calcium phosphate phosphates with their solubility in dihydrate, mono-dicalcium water, dilute hydrogen chloride, dilute phosphates, di- citric acid and neutral ammonium monocalcium phosphates. 21, 22 7758-23-8 Sullivan TW 1992 citrate. turkey Poultry Science. 71:2065-2075 Evaluation of new and established monocalcium phosphate, feed phosphates in turkey starter dicalcium phosphate 21, 22 7758-23-8 Sullivan TW et al 1989 diets turkey Poultry Science. 68(1):143 bioavailability of phosphorous in monocalcium hposphate, commercial phosphate supplements dicalcium phosphate 21, 22 7758-23-8 Waibel PE et al 1984 for turkeys. turkey Poultry Science. 63:730-737 Nitrogen and Phosphorus Partitioning Knowlton KF, Herbin JH, in Lactating Holstein Cows Fed monocalcium phosphate, Meister-Weisbarth MA and Different Sources of Dietary Protein dicalcium phosphate 21, 22 7558-23-8 Wark WA 2001 and Phosphorus cows J. Dairy Sci. 84:1210–1217 The effects of phosphorus monocalcium phosphate, supplementation to common carp dicalcium phosphate 21, 22 7758-23-8 Hepher B & Sandbank S 1984 diets on fish growth. fish Aquaculture, 36:323-332

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Laying hens respond differently to high dietary levels of phosphorus in monocalcium phosphate, monobasic and dibasic calcium dicalcium phosphate 21, 22 7758-23-8 Keshavarez K 1994 phosphate. hens Poultry Science. 73: 687-703 Calcium bis(dihydrogenorthophosph ate), Calcium hydrogenorthophosphate, ammonium dihydrogenorthophosphate, Thermomagnesium phosphate Laboratory evaluations of feed-grade 21, 22, 18 7758-23-8 Lima FR et al 1999 and agricultural-grade phosphates N/A Poult. Sci. 78(12):1717-1728 Influence of dietary calcium, phosphorous, zinc and sodium calcium phosphate phytate level on cateract incidence, monobasic, calcium growth and histopathology in juvenile phosphate dibasic, sodium Chinook salmon (Oncorhynchus phosphate monobasic. 21, 22, 2 7758-23-8 Richardson NL et al 1985 tshawytscha). fish American Institute of Nutrition. 553-567

Monocalcium phosphate, Dicalcium phosphate, Beta- tricalcium phosphate, Tricalcium phosphate Studies on the availability of calcium 21, 22, orthophosphate to chickens and 23, 24 7758-23-8 Gillis MB et al 1952 turkeys chicken J. Nutr. 78(2): 155-161 Wise DL, Trantolo DJ, Altobelli DE, Yaszemski Encyclopaedic handbook of MCP, DCP, HAP, Calcium 21, 22, MJ, Gresser JD and biomaterials and bioengineering. Part sodium phosphate, β-TCP, 23, 24 7758-23-8 Schwartz B: Applications. Vol 1 Dicalcium phosphate, tricalcium phosphate, The action of water upon the monocalcium phosphate 21, 22, 24 7558-23-8 Cameron FK and Siedell A 1910 phosphates of calcium. N/A J Am Chem Soc 26: 1454-1463 Moncalcium phosphate Handling of non-sink conditions: In hydrate, dibasic calcium vitro dissolution rates of some phosphate, basic tricalcium common pharmaceutical calcium Drug development and industrial pharmacy, phosphate 21, 22, 24 7758-23-8 Carstensen JT 1988 salts N/A 14(4): 1971-1989

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monocalcium phosphate, Characterisation of phosphate dicalcium phosphate, Frossard E, Tekely P and species in urban sewage sludges by tricalcium phosphate, 21, 22, 24 7758-23-8 Grimal JY 1994 high-resolution solid-state 31P NMR. sewage sludge European Journal of Soil Science. 45: 403-408 monocalcium phosphate, dicalcium phosphate, tricalcium calcium phosphate fertilizers: II a phosphate/hydroxyapatite, 21, 22, petrographic study of their alteration octocalcium phosphate 24, n/a 7758-23-8 Lehr J.R. And Brown W.E. 1958 in soils soil soil sci soc amer proc 22: 29-32 monocalcium phosphate, dicalcium phosphate, tricalcium calcium phosphate fertilizers: I phosphate/hydroxyapatite, 21, 22, availability to plants and solubility in octocalcium phosphate 24, n/a 7758-23-8 Terman G.L. Et al 1958 soils varying in pH ryegrass soil sci soc amer proc 22: 25-29 monocalcium phosphate, Bioavailability of bone precipitated dicalcium phosphate, 21, 22, Sullivan TW and Douglas dicalcium phosphate in turkey starter defluorinated phosphate n/a 7758-23-8 JH 1987 diets. turkey Poultry Sci(1): 182 monocalcium phosphate, A triple response method fpr dicalcium phosphate, determining biological value of defluorinated phosphate, 21, 22, phosphorus sources with young tricalcium phosphate n/a, 24 7758-23-8 Sullivan TW 1966 turkeys turkey Poultry Science. 45:1236-1245 effects of inorganic salts upon biology and development of acarid mites> IV. Effects of calcium phosphate surplus in food upon fecondity, life spam and development monocalcium phosphate, of copra mite Tyrophagus tricalcium phosphate 21, 24 7758-23-8 Ignatowicz S. 1980 putrescentia acarid mites polish J entomo 50: 289-298 monocalcium phosphate, calcium pyrophosphate, monosodium phsohate, sodium acid pyrophosphate, calcium Biological avaiilability of nutrients in metaphosphate, sodium 21, 26, 2, feeds: availability of major mineral metaphosphate 5, 7758-23-8 Peeler HT 1972 ions. sheep J Anim Sci 1972. 35:695-712. monocalcium phosphate, Magnesium phosphate The dissociation of Calcium and 21, 29 7758-23-8 Greenwald I et al 1940 Magnesium Phosphates. N/A J Biol Chem, 135: 65-67

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R. A. ARGENZIO, J. E. dicalcium phosphate, LOWE, H. F. HINTZ, AND Calcium and Phosphorus monosodium phosphate 22, 2 7757-93-9 H. F. SCHRYVER 1974 Homeostasis in Horses horse J Nutr. 104. 18-27

Calcium hydrogen orthophosphate, Calcium bis(dihydrogenorthophosph ate), Ammonium Relative bioavailability of phosphorus dihydrogenorthophosphate in feed and agricultural phosphates 22, 21, 18 7757-93-9 Fernandes JIM et al 1999 for poultry. poultry Poult. Sci. 78:1729-1736. The effect of feeding calcium phosphate salts with different dicalcium phosphate solubilities on dental caries, the dihydrate, dicalcium composition of the saliva and the pyrophosphate 22, 26 7789-77-7 Buttner W. and Muhler J.C. 1958 femur of rats Rats J. D. Res. 37(5): 860-864 Soluble complexes in the systems Calcium dicalcium phosphate dihydrate or hydrogenorthophosphate, dimagnesium phosphate trihydrate Dimagnesium phosphate equilibrated with aqueous salt 22, 29 7757-93-9 Webber MD 1970 solutions N/A Can. J. Soil. Sci. 50:243-253 Comparative effects of oral administration of urea and urea phosphate on the concentrations of dicalcium phosphate and Hemingway RG, Parkins JJ ammonia and urea in the blood of urea phosphate 22, 51 231-826-1 and Ritchie NS 1972 sheep Sheep Br. Vet. J:. 128: dicalcium phosphate stability of dicalcium phosphate dihydrate, octacalcium dihydrate in aqueous solutions and phosphate 22, n/a 7789-77-7 Moreno E.C. Et al 1960 solubility of octocalcium phosphate soils soil. Science soc. Proc: 99-102 The availability of phosphorus from beta-tricalcium phosphate, 7758-87-4, single and combined phosphates to dicalcium phosphate 23, 22 7757-93-9 Nelson TS and Peeler HT 1961 chicks chicken Poultry Sci 40:1321-1328 The effects of calcium phosphate hydroxyapatite, beta- 7758-87-4, Ducheyne P, Radin S & ceramic composition and structure Journal of Biomedical materials research. 27: tricalcium phosphate 23, 24 12167-74-7 King L 1993 on in vitro behaviour. I. Dissolution n/a 25-34 beta-tricalcium phosphate Tricalcium phosphate The basic calcium phosphates and 7758-87-4, Eisenberger S, Lehrman A related systems. Some theoretical 23, 24 1306-06-5 and Turner WD 1938 and practical aspects N/A Chem Rev. 26:257-96

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The FITR Spectroscopy ans OXDR Slosarczyk A, studies of calcium phosphate based hydroxyapatite, beta- 7758-87-4, Paluszkiewicz C, Gawlicki materials produced from the powder tricalcium phosphate 23, 24 12167-74-7 M & Paszkiewicz Z 1977 precursors with different Ca/P ratios n/a Ceramics international. 23. 297-304 beta-tricalcium phosphate, deflurinated phosphate, 7758-87-4, The biological evaluation of dicalcium phosphate, 23, n/a, n/a, 7757-93- phosphorus compounds. A monocalcium phosphate 22, 21 9, 7758-23-8 Nelson TS and Walker AC 1964 summary. chicken Poultry Sci 43:94-98 Tricalcium phosphate, Dicalcium phosphate, Monocalcium phosphate, Phosphoric acid 24, 22, 21, 48 12167-74-7 Cameron FK and Seidell A 1905 The Phosphates of Calcium I. N/A J AM Chem Soc 27(12): 1503-1512 tricalcium phosphate, Toxicity of calcium phosphate to monocalcium phosphate 24, 21 12167-74-4 Majumder S.K., Bano A. 1964 some pests of stored grain insects Nature 202: 1359-1360 tricalcium phosphate, monocalcium phosphate, dicalcium phosphate, monosodium phosphate, disodium phosphate, monopotassium 24, 21, Effect of Various Types of phosphate, dipotassium 22, 2, 3, Satoh SH, Porn-Ngam N, Phosphates on Zinc Availability to phosphate, phosphoric acid 12, 13, 48 12167-74-7 Takeuchi T and Watanbe T 1993 Rainbow Trout fish Nippon Suisan Gakkaishi. 59(8): 1395-1400

Hydroxyapatite, Tricalcium phosphate, Monocalcium phosphate monohydrate, Β- tricalcium phosphate, Dicalcium phosphate dihydrate, Vitreous calcium metaphosphate, Fluorapatite, Potassium Rates of Solution of Calcium calcium pyrophosphate 24, 21, Phosphate in Phosphoric Acid Agricultural and Food Chemistry. 5(4): 266- 23, 22 12167-74-7 Huffman EO et al 1957 Solutions N/A 275

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TCP, DCP/DCPA and DCP Calcium phosphates – speciation, dihydrate 24, 22 12167-74-4 Nancollas GH 1979 solubility and kinetic considerations. ACS Symposium 93: 475-497

Raynaud S, Champion E, Determination of calcium/phosphorus hydroxyapatite, beta- Bernache-Assolant and atomic ratio of calcium phosphate tricalcium phosphate, 24, 23 1306-06-5 Laval JP 2001 apatites using x-ray diffractometry N/A J. Am Ceram. Soc. 84(2): 359-366 X-ray Diffraction of calcined bone hydroxyapatite, beta- Balmain N, Legros R and tissue: a reliable method for the tricalcium phosphate 24, 23 12167-74-4 Bonel G 1982 determination of bone Ca/P molar. n/a Calcified Tissue International. 34:S93-S98 Tissue response to implants of tricalcium phosphate, beta- Flatley TJ, Lynch KL and calcium phosphate ceramic in the tricalcium phosphate 24, 23 12167-74-4 Benson M 1983 rabbit spine Rabbit Clinical orthop Rel Res. 179: 256-252 DICALCIUM PYROPHOSPHATE, SODIUM METAPHOSPHATE rate and mechanism of its hydrolytic INSOLUBLE 26, 11 7790-76-3 Huffman E.O and Fleming J.D.1960 degradation . J. Phys. Chem. 64:240-244 Chow L.C., Takagi S., dicalcium pyrophosphate, Effect on whole saliva of chewing Shern R.J., Chow T.H., monocalcium phosphate, 26, 21, gums containing calcium Journal of dental research.73,26-32. Takagi K.K and Sieck B.A tetracalcium phopshate. 22, 7790-76-3 1994 phosphates. human http://jdr.sagepub.com/cgi/reprint/73/1/26.pdf calcium pyrophosphate, Polyphosphate Hydrolysis of ammonium pyrophosphate, Ammonium, calcium and calcium calcium ammonium 26, n/a, Hossner L.R. And Melton ammonium pyrophosphates in pyrophosphate n/a 7790-76-3 J.R. 1970 selected Texas soils soil soil sci soc amer proc 34: 802-805 iron phosphate, aluminium The action of water and saline phosphate, tricalcium solutions upon certain slightly soluble The Journal of The American Chemical phosphate, 27, 40, 24 10045-86-0 Cameron FK and Hurst LA 1904 phosphates. N/A Society. 26(8): 885- 913. Dimagnesium phosphate, Ferric phosphate The Phosphates of Magnesium and 29, 27 7757-86-0 Cameron FK and Bell JM 1907 Iron N/A J Phys Chem 11(5): 363-368

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MgHPO4.3H2O (newberite) Mg3(NH4)2(HPO4)4.8H2O Mg3(NH4)2(HPO4)2.4H2O –A (Schertelite) Mg3(NH4)2(HPO4)2.4H2O –B MgNH4PO4.6H2O (struvite) 29, 30, Frazier AW and Waerstad The phase system MgO-(NH4)2O- 31, 60 7757-86-0 KJ 1992 P2O5-H2O at 25°C. N/A Ind Eng Chem Res, 31: 2065-2068 disodium hydrogenorthophosphate, dipotassium 7558-79-4, hydrogenorthophosphate 3, 13 7758-11-4 Ravich MI and Popova ZV 1942 ? N/A Izv Akad Nauk SSSR. ?:268-273 Bernstein D.S, Newton R. The effect of oral sodium phosphate disodioum phosphate, on the formation of renal calculi and monosodium phosphate 3, 2, 7558-79-4 1966 on idiopathic hypercalcuria. The Lancet. Nov. 19:1105-1107 disodium phosphate, calcium phosphate monobasic, calcium Further observations on the phosphate dibasic 3, 21, 22 7558-79-4 McClure F.J and Muller A. 1959 cariostatic effects of phosphates Rats J. D. Res. 38(4): 776-781 the cariostatic effect in white rats of Na2HPO4, calcium phosphorus and calcium phosphate monobasic, supplements added to the flour of calcium phosphate dibasic 3, 21, 22 7558-79-4 McClure F.J. 1960 bread formulas and to bread diets Rats J. Nutrition 72: 131-136

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium phosphate (Na2HPO4), trisodium phosphate, sodium acid pyrophosphate, trisodium trimetaphosphate (3- hydrate), sodium metaphosphate, sodium hexametaphosphate, monopotassium phosphate, potassium Antibacterial action against pyrophosphate, potassium 3, 4, 5, 8, streptococuss mutans and inhibitory polyphosphate (add. Non- 9, 10, 12, effect on the experimental Hamster ip substances) 15, 17 7558-79-4 Shibata H 1981 caries of condense phosphates bacteria Fukuoka Igaku Zasshi 6:379-391 disodium phosphate dodecahydrate, Nofre C., Dufour H. and compared toxicity of 32 mineral comptes rendus des sceances de l'academie phosphoric acid, 3, 48 7558-79-4 Cier A. 1963 anions in the mice mice des sciences 257: 791-794 disodium phosphate, sodium acid pyrophosphate, tetrasodium pyrophosphate, sodium factors affecting sensitivity of metaphosphate, sodium 3, 5, 7, 9, Staphylococcus aureus 196E to applied and environmental microbiology: 842- tetrametaphosphate n/a 7558-79-4 Jen C.M.C, Shelef L.A. 1986 polyphosphates bacteria 846 disodium hydrogenphosphate, 7558-80-7, Uber verbindungen von tetrasodiumpyrophosphate, 7722-88-5, alkaliphosphaten mit monopotassium phosphate 3, 7, 12 7778-77-0 Menzel VH and Gabler C 1929 wasserstoffperoxyd N/A Z Anorg Chem. 177:187-198 disodium phosphate, tetrasodium pyrophosphate, trisodium trimetaphosphate, Effects of dietary phosphate diammonium phosphate, 3, 7, 8, Van Reen R. and Ostrom supplements on dental caries in the calcium phosphate dibasic 19, 22 7558-79-4 C.A. 1962 rat Rats J. D. Res 41: 875-882

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

disodium phosphate (DSP), tetrasodium polyphosphate, grahams salt, potassium dihydrogen Research into the toxicity and effects Amoeba and orthophosphate, calcium of polyphosphates on growth of rotifer and phosphate monobasic, 3, n/a, 9, cultures of amoeba, rotifers, Amphibian calcium phosphate tribasic, 12, 21, tadpoles, and on the succession of (Bufo bufo and institut fur Landwirtschaftliche Zoologie und iron pyrophosphate 24, 28 7558-79-4 Wuembach et al 1966 organisms in cellulose decomposition Xenopus laevis) bienenkunde, Report 33 pages disodium phosphate, sodium acid pyrophosphate, sodium hexametaphosphate, 3,5, 10, effects of some phosphates in a short- phosphoric acid 48 7558-79-4 Konig K.G. Et al 1961 period rat caries experiment Rats Arch. Oral biol. 3: 258-270 Magnesium hydrogen phosphate prepared at the 26th JECFA (1982) trimagnesium phosphate, published in 1982 and 1992. potassium tripolyphosphate 30, 16 7757-87-1 63rd JECFA 2004 Revised at the 63rd JECFA (2004). n/a n/a Trimagnesium phosphate prepared at the 17th trimagnesium phosphate, JECFA (1973) published in 1978 and 1992. trisodium phosphate 30, 4 7757-87-1 57th JECFA 2001 JEFCA N/A Revised at the 57th JECFA (2001). trisodium phosphate, Bucher k., Bucher K.E., The topically irritant substance: monosodium phosphate 4, 2 7601-54-9 Walz D. 1981 Essentials-bio-test-predictions. Agents and actions, 11(5): 515-519 trisodium phosphate, Simon I. monosodium phosphate Minimal Lethal Dose of some Sodium 4, 2 7601-54-9 1939 Salts Injected Intravenously. Boll Soc Ital Biol Sper, 14():136-137 Abderhalden E. Handbuch der biologischen Arbeitsmethoden: Chemische und physikalische trisodium phosphate, 7601-54-9, Untersuchungsmethoden der disodium phosphate 4, 3 7758-79-4 1935 Pharmakologie und Toxikologie. ? 4: 1382 - 1383 trisodium phosphate, Studien an alkaliphosphaten und disodium 7601-54-9, arsenaten II): Tertiares hydrogenorthophosphate 4, 3 7758-79-4 Menzel 1937 natriumphosphat N/A Ztschr. Elektrochem. 43 (2): 104-

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested trisodium phosphate anhydrous, sodium acid pyrophosphate, tetrasodium pyrophosphate, ABSTRACT: Dermal toxicity/ skin tripotassium phosphate, 4, 5, 7, irritation studies on five inorganic monocalcium phosphate 14, 21 7601-54-9 Weiner M. et al 1987 phosphates Rabbits ? trisodium phosphate anhydrous, sodium acid pyrophosphate, tetrasodium pyrophosphate, tripotassium phosphate, 4, 5, 7, ABSTRACT: Eye irritation studies on monocalcium phosphate 14, 22 7601-54-9 Weiner M. et al 1986 five inorganic phosphates Rabbits ? trisodium phosphate, sodium acid pyrophosphate, trisodium trimetaphosphate, sodium Pharmacology of the meta hexametaphosphate 4, 5, 8, 10 7758-16-9 Behrens B. and Seelkopf K. 1933 phosphoric acids mice arch exp path pharmak 169():238 trisodium phosphate, Bell R.N. Estimation of triphosphoric and tetrasodium pyrophosphoric acids: In the pyrophosphate, sodium presence of ortho- and hexametaphosphates 4, 7 , 10 7758-16-9 1947 metaphosphoric acids. n/a Anal. Chem. 19:97-100 Observations on the effect of trisodium phosphate, intravenous injections of sodium Journal of Pharmacology and Experimental monosodium phosphate 4,2 Greenwald I 1915 phosphate rabbit, dog Therapy. 7: 57-61 trisodium phosphate, Irani R.R. and Callis C.F. tetrasodium pyrophosphate, sodium metaphosphate insoluble, tetrapotassium Calcium and magnesium pyrophosphate, sodium 4,7, 11, sequestration by sodium and Journal of the American Oil Chemists' tripolyphosphate 15, 0 7601-54-9 1962 potassium polyphosphates. n/a Society. March: 156-159 Aluminium Hanawa T, Kaga M, Itoh Y, orthophosphate, Echizenya T, Oguchi H and Cytotoxicities of oxides, phosphates hydroxyapatite 40, 24 7784-30-7 Ota M 1992 and sulphides of metals. N/A Biomaterials. 13(1): 20 – 24 aluminium phosphate, iron A study of dust toxicity using a British Journal of Industrial Medicine. 13: 187- phosphate 40, 27 7784-30-7 Marks J et al 1956 quantitative tissue culture technique. N/A 191

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested aluminium phosphate, Etudes physico-chemiques de magnesium hydrogen AlPO4, de MgHPO4.3H2O et leurs Acta Poloniae Pharmaceutica- Drug Research. phosphate 40, 29 7784-30-7 Boudraa M’hamed et al 1991 melanges. N/A 48(3-4): 63-68 Aluminium orthophosphate dihydrate, hydroxyapatite, dicalcium phosphate dihydrate, Iron 40. 24, Lindsay WL and Moreno orthophosphate dihydrate 22, 27 7784-30-7 EC 1960 Phosphate phase equilibria in soils N/A Soil sci soc Am J. 24(3):177- 182 sodium potassium polyphosphate, trisodium the hydrolyse of condensated trimetaphosphate 46, 8 24315-83-1 Thilo E. and Wieker W. 1959 phosphates in aqueous solution water Naturwissen, 46:367-373 Clinical Trial of a Combined MFP- sodioum NaF Dentifrice Formulated at monoflurophosphate 47 10163-15-2 Ripa LW & Leske GS 1985 Different Concentrations Human NTIS Fisher AA disodium fluorophosphate, monoammonium Contact Dermatitis From Foods and phosphate, monosodium Food Additives. 582-594 and Contact Dermatitis Third edition Lea & Febiger phosphate 47, 18, 2 10163-15-2 1986 851,855 and 904 Philadelphia 1986 Phosphoric acid, Graham’s salt The system zinc oxide, phosphorous 48, 11 7664-36-2 Eberly NE et al 1920 pentoxide and water at 25° and 37° N/A J Am Chem Soc, 42(7): 1433-1439 Phosphoric acid, Potassium dihydrogenorthophosphate, Tripotassium orthophosphate, Ammonium dihydrogenorthophosphate, Diammonium hydrogenorthophosphate, The ternary systems, Potassium – Triammonium phosphate 48, 12, Phosphoric acid – Water and 14, 18, 19 7664-38-2 Parker EG 1914 Ammonia – Phosphoric acid – Water N/A J Phys Chem, 18: 653-661 phosphoric acid, monoammonium Polyphosphoric acids and their phosphate 48, 18 7664-38-2 Kubasova L V 1971 ammonium salts. Russian Chemical Reviews, 40 (1) 1 - 12.

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested phosphoric acid, diammonium phosphate, sodium acid Ortho Vs. Poly. Author takes a look pyrophosphate, sodium 48, 19, 5, at the history and behaviour of ortho tripolyphosphate 0 7664-38-2 Lohry R 2001 and polyphosphates. Fluid Journal N/A Fluid Journal phosphoric acid, monocalcium phosphate, sodium Toxicology of the eye, Second Edition. Charles hexametaphosphate 48, 21, 10 7664-38-2 Grant W M, . 1974 Toxicology of the Eye (Handbook) rabbit C Thomas USA Phosphoric acid, iron The system ferrous oxide-phosphoric phosphate Carter SR and Hartshorne acid-water and some of its oxidation 48, 27 7664-36-2 NH 1926 products N/A ? phosphoric acid, trisodium orthophosphate 48, 4 7664-38-2 Young JR et al 1988 classification without testing N/A Toxic in vitro, vol 2, no 1, pp 19-26, 1988 Measure of photosynthesis and of orthophosphoric acid, Beranger-Yvon. A., growth, Chlorella alga (8 days algae (chlorella revue de cytologie et de biologie vegetale (19): pyrophosphoric acid 48, 50 7664-38-2 Champighy M.L., Guyon D. 1958 culture) pyrenoidosa) 433-452 Bloch-Frankenthal L. The role of magnesium in the hydrolysis of sodium pyrophosphate Sodium pyrophosphate 5 (OR 7) 7758-16-9 1954 by inorganic pyrophosphatase. rat (blood) Biochem J. 57,1: 97-92 cytogenetic effects of inorganic Natarajan A.T. And pyrophosphate and 5-fluoro plant (vicia sodium pyrophosphate 5 (OR 7) 7758-16-9 Ahnsrom G. 1968 deoxyuridine faba) Hereditas 59 (2-3): 229 Sodium pyrophosphate 5 (OR 7) 7758-16-9 Salzer 1894 ? N/A Arch Pharm 232: 365-375 sodium acid pyrophosphate / sodium Effect of some chemicals used in oil diverse marine pyrophosphate 5 / 7, 7758-16-9 Daugherty F.M. 1951 well drilling on marine animals invertebrates sewage ind. Wastes 23: 1282-1287 Sodium pyrophosphate (SAPP or TSPP) 5 or 7 7758-16-9 Bayer KJ 1869 1) Chemische Notizen N/A J Prakt Chem, 106: 501 Cumulative toxicities of some inorganic salts to daphnia magna as determined by median tolerance Sodium pyrophosphate 5, 7758-16-9 Dowden B 1961 limits Daphnia Proc La Acad Sci, 23: 77-85

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Inhibition of Clostridium sporogenes PA 3679 and Natural Bacterial Flora of Cooked Vacuum-Packaged Bratwurst by Sodium Acid Pyrophosphate and Sodium sodium acid Molins RA, Kraft AA, Olson Tripolyphosphate With or Without pyrophosphate, sodium DG, Walker HW & Added Sodium Nitrite tripolyphosphate 5, 0 7758-16-9 Hotchkiss DK 1986 bacteria Journal of Food Science. 51(3): 726-731 sodium acid pyrophosphate, potassium dihydrogenphosphate, tetrapotassium 7758-16-9, pyrophosphate, 7778-77-0, monocalcium phosphate, 7320-34-5, calcium dihydrogen 7758-23-8, No 264. Etude des polyphosphates pyrophosphate, calcium 5, 12, 15, 14866-19-4, de sodium, potassium et calcium. II. pyrophosphate 21, 25, 26 7790-76-3 Morin C 1961 Etude des polyphosphates de sodium N/A Bull. Soc. Chim. France: 1719-1740 sodium acid phosphate, Boyd, E.M., Seymour untoward and toxic reaction of a Experimental Medecine and Surgery (4):223- monosodium phosphate 5, 2 7758-16-9 K.G.W. 1946 range of different products rats 227 sodium acid Dowden B F and Bennett H invertebrates pyrophosphate, J. (various monosodium Toxicity of selected chemicals to dependent on pyrophosphate 5, 2 7758-16-9 1965 certain animals substance) j wpcf.37.1308-1316 The effect of the intravenous sodium biphosphate and administration of phosphate solutions sodium phosphate mixture 5, 2 (?) 7758-16-9 Greenfield I 1941 in normal rabbits rabbits J. Lab. Clin. Med. 7:68-70 sodium acid Sutton C.D. and Larsen S. pyrophosphate, disodium Pyrophosphate as a source of phosphate 5, 3 7758-16-9 1964 phosphorus for plants. n/a Soil Sci. 97(): 196-201 sodium acid Firstenberg-Eden R et al pyrophosphate, trisodium Inhibition of Moraxella-Acinetobacter phosphate, sodium Cells by Sodium Phosphates and tripolyphosphate 5, 4, 0 7758-16-9 1981 Sodium Chloride. Journal of Food Science 46: 579-582 sodium acid pyrophosphate, cementum: a phosphate-sensitive pyrophosphoric acid 5, 49 7758-16-9 Nociti F.H. Et al 2002 tissue rats (mutant) J. D. Res. 81(12): 817-821

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the hydrolysis of the condensed phosphates. II a) the role of the hydrogen ion in the hydrolysis of sodium pyrophosphate. II b) the sodium pyrophosphate, McGilvery J.D. And dissociation constants of pyrophosphoric acid 5, 50 7758-16-9 Crowther J.P. 1954 pyrophosphoric acid soil canadian J chem. 32: 174-185 Effect of Acid and Neutral disodium Marcy JA, Kraft AA, Pyrophosphates on the Natural dihydrogenpyrophosphate, Hotchkiss DK, Molins RA, Bacterial Flora of a Cooked Meat trisodium hydrogen Olson DG, Walker HW and System diphosphate 5, 6 7758-16-9 White PJ 1988 bacteria JOURNAL OF FOOD SCIENCE. 53(1): 28- 30

Potassium polyphosphate (Kurrol salt) mixture 2/3 tetrasodium pyrophosphate (TSPP) 1/3 disodium Van Esch GJ, Vink HH, Wit the physiological effect of pyrophosphate (SAPP) 5, 7 7758-16-9 SJ, Van Genderen H 1957 phosphates Mouse Arzneimittel-forsch 7():172-175

Marcy JA, Kraft AA, Effect of Acid and Alkaline disodium Hotchkiss DK, Molins RA, Pyrophosphate Blends on the Natural dihydrogenpyrophosphate, Olson DG, Walker HW and Flora of a Cooked Meat System tetrasodium pyrophosphate 5, 7 7758-16-9 White PJ 1988 bacteria JOURNAL OF FOOD SCIENCE. 53(1): 25-27 Boettge K., Jaeger K.H. sodium acid and Mittenzwei H. Das Adenylsäuresystem: neure pyrophosphate, ergebnisse und probleme. tetrasodium pyrophosphate 5, 7 7758-16-9 1957 Arzneimittel-Forschung. Drug Research. 7:24-59 sodium pyrophosphate, ABSTRACT: Effects of condensed sodium metaphosphate, phosphates as a food additive on the sodium liver, Kidneys, muscles, and bones of hexametaphosphate 5, 9, 10 7758-16-9 Omoto M. et al 1986 the mouse mice toxicology lett suppl 31: P1-54 sodium acid pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, sodium polyphosphate, Seward RA, Lin CF & heat sensitisation of Salmonella by calcium polyphosphate. 5, 9, 10, 7758-16-9 Melanchoris N 1986 polyphosphate bacteria Journal of food science. 51(2): 471-473

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium pyrophosphate, sodium metaphosphate, sodium hexametaphosphate, tetrapotassium pyrophosphate, potassium Mutagenicity test of food additives metaphosphate, dicalcium 5, 9, 10, with salmonella typhimurium TA97 ann. Rep. Tokyo Metr. Res. Lab. P.H. 41: 315- phosphate 15, 17, 22 7758-16-9 Fujita H. and Sasaki M. 1990 and TA102 bacteria 322 sodium acid pyrophosphate, Bactericidal and Bacteriolytic Effects tetrasodium of Selected Food-Grade Phosphates, pyrophosphate, sodium Lee RM, Bartami PA, Olson Using Staphylococcus aureus as a Journal of Food Protection, Vol. 57, No. 4, tripolyphosphate 5,7,0 7758-16-9 DG & Wiliams FD 1994 Model System Bacteria Pages 276·283 Phosphorous Properties of the 50, 48, 8, Element and Some of Its Tennessee Valley Authority Chemical 11, 17, Compounds. By the Staff of the Engineering Report No. 8 Various 22, 21 Various Farr TD 1950 Division of Chemical Engineering. N/A

50, 49, 48, 47, 11, 10, 9 (all ortho- ,pyro-, triphosphate s, 0, 5, 7, 8, 10, 11, 47, 48, Various 49, 50) Various Audrieth 1950 TEXTBOOK n/a Inorganic syn theses Volume III: 85-117 polyphosphoric acid, The effects of polyphosphoric acid magnesium and inorganic salts upon the hydrogenorthophosphate, respiration of Ehrlich Ascites Tumor sodium metaphosphate 51, 29, 9 8017-16-1 Ohta. M 1961 Cells tumor cells Nihon Univ J. Med. 3: 365-385 Memorie della Reale Academia delle scienze sodium pyrophosphate 7 (or 5) Sabbatani L 1904 Funzione Biologica del Calcio ? di Torina 54(2a):459-529 Uber die pharmakologische wirkung various: sodium kalziumfallender sauren und der Archiv fur experimentelle Pathologie und pyrophosphate 7 (or 5) Starkenstein E 1914 magnesium salze rabbit Pharmakologie ixxvii: 45-82

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The chemical news –Sodium Sodium pyrophosphates 7 or 5 7722-88-5 ? 1928 pyrophosphates N/A The mechanism of hydrolysis of polyphosphates. V.the effect of sodium pyrophosphate, 7722-88-5, Watanabe M, Matsuura M cations on the hydrolysis of pyro- and Bulletin of the Chemical Society of Japan. Sodium tripolyphosphate 7(or 5), 0 7758-29-4 and Yamada T 1981 triphosphates N/A 53(3): 738-741 sodium pyrophosphate, Uber die hydrolysegeschwindigkeit STPP ,sodium 7(or 5), 0, von pyrophosphate, tripolyphosphat hexametaphosphate 10 7722-88-5 Watzel VDR 1942 und hexametaphosphat. N/A Die Chemie. 55(47/48): 351-366 Sodium pyrophosphate Soluble crystalline polyphosphates – Sodium triphosphate their purification, analysis and The Journal of Physical Chemistry, 58(8): 603- Sodium tetraphosphate 7, 0, 7722-88-5 Quimby OT 1954 properties. N/A 618 sodium pyrophosphate, sodium tripolyphosphate, microorganism sodium Sensitivity of Pseudomonas strains s; hexamaetaphosphate 7, 0, 10 7722-88-5 Zessin KG and Shelef LA 1988 to polyphosphates in media system pseudomonas Journal of Food Science. 53(2):669-670 tetrasodium Fingerhut M et al pyrophosphate, sodium Zur Frage Der Resorption von tripolyphosphate, sodium polyphosphaten (On the question of polyphosphate 7, 0, 9 7722-88-5 1965 absorption of polyphosphates) rat D. Jolley, W. Maher & P. Rapid Method for Separating and tetrasodium Cullen Quantifying Orthophosphate and pyrophosphate, disodium Polyphosphates:Application to phosphate 7, 2 7722-88-5 1998 Sewage Samples. n/a Water Research Vol. 32, No. 3, pp.711-716 tetrasodium Heitkemper DT, Kaine LA, pyrophosphate, disodium Jackson DS and Wolnik Determination of tripolyphosphate phosphate, sodium KA, and related hydrolysis products in tripolyphosphate 7, 2, 0 7722-88-5 ? processed shrimp, n/a US FDA. pp 92-100. tetrasodium pyrophosphate, disodium orthophosphate, calcium The physiological action of some sodium phosphate, 7, 3 7722-88-5 Gardner J and Symes W 1911 camphene phosphonates of sodium rat Biochemical Journal. 5: 390 tetrasodium pyrophosphate, trisodium effects of synthetic detergents on phosphate 7, 4 7722-88-5 Smith R.S. Et al 1956 water coagulation water j am wat wks ass 48: 55-69

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested tetrasodium Friedrich Kiermeier & Zusammenfassende pyrophosphate, trisodium Klement Möhler Übersichtsberichtsberichte: Zure phosphate, disodium Verwendung der Polyphosphate bei phosphate, monosodium Lebensmitteln. Z. Lebensmittel- phosphate 7, 4, 3, 2 7722-88-5 1957 Unters. U. -Forsch., Rand 106 ? ? 41st JECFA Tetrasodium pyrophosphate prepared at the 41st JECFA publisehd in 1993, superceding tetrasodium specifications prepared at the 37th pyrophosphate, sodium JECFA, publisehd in 1992. Revised acid pyrophosphate 7, 5 7722-88-5 1993 at the 55th JECFA (2000). n/a JEFCA tetrasodium Lebron CI, Molins RA, Inhibi'tion of Growth and Aflatoxin pyrophosphate, sodium Walker HW, Kraft AA, Production of Aspergilli in Medium polyphosphate 7, 9 7722-88-5 Stahr HM 1989 Containing Phosphates yeat Journal of Food Protection, Vol. 52(1): 4-6 Tetrasodium pyrophosphate, sodium 7722-88-5, acid pyrophosphate, 7758-16-9, trisodium pyrophosphate, 14691-80-6, Crystallographic data on some dicalcium pyrophosphate 7,5,6,26 7790-76-3 Corbridge DEC 1957 hypophosphates and pyrophosphates N/A Acta Cryst. 10: 85 sodium trimetaphosphate, The mechanism of the hydrolysis of sodium condensed phosphates. III. The tetrametaphosphate, 7785-84-4, Watanable M, Sato S and mechanism of the hydrolysis of Bulletin of the Chemical Society of Japan sodium tripolyphosphate 8, 0 7758-29-4 Saito H 1975 trimeta- and tetrametaphosphates N/A 48(12): 3593-3597 Mitchell L C A paper chromatogragphic study of sodium trimetaphosphate, the effect of synthetic digestive fluids sodium on the sodium salts of Tri-, Tetra-, hexametaphosphate 8, 10 7785-84-4 1958 and Hexametaphosphoric acids. n/a? Journal of the A. O. A. C, 41, 185-188. Lanigan Final report on the safety assessment of sodium sodium trimetaphosphate, metaphosphate, sodium sodium trimetaphosphate and sodium hexametaphosphate 8, 10 7785-84-4 2001 hexametaphosphate. International Journal of Toxicology. trisodium trimetaphosphate, ABSTRACT: Effect of CaHPO4 and monocalcium phosphate 8, 21 7785-84-4 Koulourides T. 1974 TMP on carcigonicity in Human bovine enamel J. D. Res. 53: 606

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium trimetaphosphate, Dionex. tetrasodium pyrophosphate, disodium Determination of polyphosphates phosphate, sodium using ion chromatography with Dionex analysis condensed phosphates tripolyphosphate 8, 7, 3, 0 7785-84-4 2002 suppressed conductivity detection. n/a 2002.pdf sodium trimetaphosphate influence on the early development of rat 8, caries and concurrent microbial sodium trimetaphosphate [35] 7785-84-4 Henry C. and Navia J. 1969 changes Rats Caries Res. 3: 326-338 sodium polyphosphate, 68915-31-1, Ion-exchange chromatographic sodium tripolyphosphate, 7758-29-4, Matsuura N, Lin T and analysis on the chain length of Bulletin of the Chemical Society of Japan. 43: tetrasodium pyrophosphate 9, 0, 7 7722-88-5 Kobayashi Y 1970 polyphosphate products N/A 2850-2858 sodium metaphosphate, sodium hexametaphosphate, Further studies on the cariostatic potassium metaphosphate, 9, 10, 17, effect of organic and inorganic calcium phosphate dibasic 22 68915-31-1 McClure F.J. 1963 phosphates Rats J. D. Res. 42(2): 693-699 sodium hexametaphosphate, potassium metaphosphate 9, 17 68915-31-1 Lang K. et al 1955 the metabolism of polyphosphates rats Biochemische Zeit. 327: 118-125

extracellular release of enzymes from macrophages in vitro for measuring sodium metaphosphate, cellular interaction with particulate mammalian dicalcium phosphate 9, 22 10124-56-8 Lock S.O. Et al 1987 and non-particulate materials cells Toxic. In vitro 1(2): 77-83

Separation of synthetic inorganic polymers of condensed phosphates sodium metaphosphate, by capillary gel electrophoresis with sodium trimetaphosphate 9, 8 10124-56-8 Wang T and Li SFY 1998 indirect photometric detection. n/a Journal of Chromatography A, 802:159-165 Fluorine from rock phosphate N/A N/A Zumpt I 1975 Chronic flouride poisoning in sheep Sheep J S Afr Vet Ass, 46: 161-163

Various N/A N/A Molins RA Phosphates in Food (handbook) Various N/A

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Integrated risk information system. ReferenceDoseForChronic Http://www.epa.gov/iris/subst/0697.ht phosphorus N/A N/A OralExposure m Uber die Beeinflussung von Daphnia Sodium potassium magna durch einige Salze und Kungl Fysiografiska Sallskapets I Lung phosphate N/A N/A Nanmann E 1933 Salzmischungen Daphnia Forhandlingar Bd 4, Nr 2

Contact uptake of metal compounds and their molluscicidal effects on the Iron (III) pentandenionate slug, Deroceras reticulatum (Muller) Iron (III) diazaalkanolate N/A N/A Bullock JI et al 1992 (Pulmonata: Limacidae) Slug Crop protection, 11: 329-334 Fire Retardants and Ecological effects of fire fighting Conference Proceedings, Australian Bushfire Firefighting Foams N/A N/A Adams R and Simmons D 1999 foams and retardants. N/A Conference, Albury July 1999 Calcium metaphosphate Hydrolysis of condensed phosphates CMP N/A 77489-25-9 Allmaras R.R. 1965 in soils soil soil science soc proceedings 487-488 the toxicity thresholds of various substances found in industrial wastes as determined by the use of daphnia daphnia No IP substances studied N/A N/A Anderson BG 1944 magna magna. Sew Works J. 16(6):1156-1165 Arlauskas A, Baker RSU, No IP substances Bonin AM, Tandon RK, investigated N/A N/A Crisp PT and Ellis J 1985 Mutagenicity of metal ions in bacteria Environmental Research. 36: 379-388 Averbuch-Pouchot and ultraphosphates N/A N/A Durif A 1992 Crystal Chemistry of Ultraphosphates n/a Zeeitschrift fur Kristallographic 201: 69-92 Studies of Phosphates. Part II. Orthophosphates of the type M3(PO4)2,XH2O. 871-882 Ammonium magnesium Part IV. Pyrophosphates of some phosphate along with a bivalent metals and their double number of other salts, and solid solutions with sodium Bassett & Bedwell Studies of Phosphates I - IV phosphates N/A N/A Bassett H and Bedwell WL 1933 pyrophosphates. 1412-1429 and 871-882 No IP substances Bautista EM and Alexander Reduction of inorganic compounds microorganism evaluated N/A N/A M 1972 by soil microorganisms. s Soil Sci Soc Am J. 36(6) Hydrolytic degradation of Sodium and potassium polyphosphates in liquid detergent polyphosphate N/A N/A Bennet et al 1957 formulations N/A Soap and Chem Spec 33: 44-47

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Comparative toxicity of No IP substances Biesinger KE, Lemke AE, polyelectrolytes to selected aquatic investigated N/A N/A Smith WE and Tyo RM 1976 animals. fish J Water Pollut Control Fed. 48(1):183-187 Amorphous calcium metaphosphate Calcium metaphosphate as a phosphorous supplement for white leghorn CMP N/A N/A Bird HR, Caskey CD 1943 chicks chickens Poultry Sci. 22:333-334 Toxicity of chemical fire retardants to juvenile coho salmon and rainbow Diss Abstr Int B Sci Eng - phD thesis Univ Unknown N/A N/A Blahm TH 1979 trout Fish Idaho, ID 40, 39(9): 4115 Effect of Chemical Fire Retardants Phos-Chek XA, Fire-Trol on the Survival of Juvenile National Marine Fisheries Service 931 N/A N/A Blahm TH and Snyder GR 1973 Salmonids. N/A Environmental Facility Prescott, Oregon. Toxicite apparentte de certain engrais phosphates et intoxication manganique induite. Journee Unknown N/A N/A Boyer J 1980 Georges Aubert. ? ?

Fire-Trol GTS-R, Fire-Trol Acute Toxicity of Fire-Retardant and LCG-R, Phos-Chek WD- Foam-Suppressant Chemicals to 881 and Ansul Silv-Ex and Early Life Stages of Chinook Salmon Environmental Toxicology and Chemistry, Phos-Check D75-R N/A N/A Buhl KJ and Hamilton SJ 1998 (Oncorhynchus tshawytscha) Fish 17(8): 1589-1599 Fire-Trol LCA-F, Fire-Trol LCM-R and Phos-Chek 259F, FireFoam 103B, FireFoam 104, Fire Quench, ForExpan S, Acute Toxicity of Fire-Control Pyrocap B-136 and other Chemicals, Nitrogenous Chemicals Transactions of the American Fisheries chemicals. N/A N/A Buhl KJ and Hamilton SJ 2000 and Surfactants to Rainbow Trout. Fish society. 129: 408-418 Buscemi DM, Hoffman DJ, Effects of Phos-Chek G75-F and Silv- Phos-Chek G75-F and Silv- Vyas NB, Spann JW and Ex on red-winged blackbird (Agelaius Ex N/A N/A Kuenzel WJ 2007 phoeniceus) embryos. Birds Environmental Pollution, 148: 312-315

Buscemi DM, Hoffman DJ, Effects of Phos-Chek G75-F and Silv- Phos-Chek G75-F and Silv- Vyas NB, Spann JW and Ex on Developing Northern Bobwhite Ex N/A N/A Kuenzel WJ 2002 Quail (Colinus virginianus) Birds Erch Eviron Contam Toxicol 43: 330-337 The solubility of calcium sulphate in No phosphates N/A N/A Cameron FK and Brown BE 1905 solutions of other salts N/A J Phys Chem 9(3): 210-215 Chaurasia LC anf Rahtor Mitotic effects of superphosphate on superphosphate N/A N/A JS 1980 somatic cells of Allium sativum plants Sci Cult, 46: 150-152

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Chaurasia OP and Sinha Cytogenic effects of single super Perspectives in cytology and genetics, 5: 349- Single super phosphate N/A N/A Sp 1986 phosphate on onion root tip cells. plants 352 Induction of Mitotic-Chromosome Chaurasia OP and Sinha Anomalies in Mice by Single Super Single Super Phosphate N/A N/A SP 1988 Phosphate Mice Cytologia, 53: 485-489 The Structural Chemistry of American Elsevier Publishing Company, Inc. Phosphorous N/A N/A Corbridge DEC 1974 Phosphorus. N/A ISBN: 0-444-41073-2

Accidental superphosphate fertiliser SUPERPHOSPHATE N/A N/A East NE 1993 poisoning in pregnant ewes. sheep JAVMA. 203(8): 1176-1177 Increased Incidence of Fractures in Middle-aged and Elderly Men with Unspecified N/A N/A Elmstahl S et al 1998 low intakes of phosphorus and zinc human Osteoporos Int 8:333-340 The Chemistry of Phosphorus. Environmental, organic, inorganic, biochemical and spectroscopic Phosphorous N/A N/A Emsley J and Hall D 1976 aspects. N/A John Wiley and Sons. ISBN: 0-470-23869-0

Phosphorous trichloride, phosphorous pentachloride, EPA Summary review of health phosphorous oxychloride, effects associated with elemental and phosphoryl chloride, inroganic phosphorous compounds: phosphorous sesquisulfide N/A N/A EPA 1990 Health issue assessment rabbits, fish EPA/600/8-89/072 sodium ammonium Enlargement of parathyroid glands phosphate N/A 13011-54-6 Fazekas, IG 1954 by simple acidic compounds rabbits J. Anim. Sci. 80:1690-1695 Toxicity of combinations of certain No IP substances inorganic compounds to Daphnia investigated N/A N/A Freeman L and Fowler I 1953 magna stratus. Daphnia Sewage and Industrial wastes. 25(10): 1191-1195 Fire-Trol GTS-R, Fire-Trol LCG-R, Phos-ChekD75-F, Gaikowski MP, Hamilton Acute toxicty of Firefighting Chemical Phos-Chek WD-881 and Sj, Buhl KJ, McDonald SF Formulations to Four Life Stages of Ecotoxicology and Environmental safety. 34: Silv-Ex. N/A N/A and Summers CH 1996 Fathead Minnow. Fish 252-263 Acute Toxicity of Three Fire- Fire-Trol GTS-R, Fire-Trol Retardant and Two Fire-Suppressant LCG-R, Phos-ChekD75-F, Gaikowski MP, Hamilton Foam Formulations to the Early Life Phos-Chek WD-881 and Sj, Buhl KJ, McDonald SF Stages of Rainbow Trout Environmental Toxicology and Chemistry, Silv-Ex. N/A N/A and Summers CH 1996 (Oncorhynchus mykiss) Fish 15(8): 1365-1374

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Site-specific acute and chronic No IP substances Gersich FR and Hopkins toxicity of ammonia to Daphnia Environmental Toxicology and Chemistry, 5(5): investigated N/A N/A DL 1986 magna straus Daphnia 443-447 ammonium pyrophosphate Gilliam J.W. And Sample Hydrolysis of pyrophosphates in ? (NH4)2 HP2O7 . H2O N/A N/A E.C. 1968 soils: pH and biological effects soils soil science 106(5): 352-357 Progress of Medical Science. Gold MD(Ed.) Hoppe JO, Therapeutics: A review of the toxicity Iron compounds N/A N/A Marcelli GMA, Tainter ML 1955 of iron compounds. various Am J Med Sci. 230(5): 558-571 Use of scintillometric quantitation of unscheduled DNA synthesis in No IP substances isolated rat hepatocytes for the investigated N/A N/A Hsia MTS 1987 screening of genotoxic agents. rat hepatocytes Cell biology and Toxicology. 3(2): 127- cyclophosphates N/A N/A Kalliney SY 1972 Cyclophosphates n/a Topics in Phosphorous Chemistry, 7: 255-309 various N/A N/A Kanazawa T 1989 Inorganic phosphate mat erials N/A Materials science monographs. 52 (Book) Unidentified inorganic microorganism phosphate N/A N/A Kanematsu N and Kada T 1978 Mutagenicity of metal compounds. s Unknown source. 215-216 Kempf CA, Greenwood DA Studies relating to the toxicity of mice, rats, no IP substances N/A N/A & Nelson VE 1937 fluorine compounds dogs J. Lab. Clin. Med. 22:1133-1137 Riegel's handbook of industrial chemistry. 9th Various N/A N/A Kent JA (Ed) 1992 N/A Ed triammomium reactions of ammonium ortho- and pyrophosphate polyphosphate fertilizer in soil: I monohydrate TPP N/A N/A Khasawneh F.E. Et al 1974 Mobility of Phosphorus soils soil sci soc amer proc 38: 446-451 triammomium reactions of ammonium ortho- and pyrophosphate polyphosphate fertilizer in soil: II monohydrate TPP N/A N/A Khasawneh F.E. Et al 1979 Hydrolysis and reactions with soil soil soil sci soc amer proc 43: 52-58 Acute toxicity of agricultural fertilizers Single Super Phosphate N/A N/A Konar SK and Sarkar SK 1982 to fishes. Fish Geobios, 10: 6-9 Landi E, Logroscino G, Biomimetic Mg-substituted Proietti L, Tampieri A, hydroxyapatite: from synthesis to in Mg-substituted HAP N/A N/A Sandri M and Sprio S 2008 vivo behaviour. N/A J MaterSci: Mater Med. 19:239-247

Effects of Fire Retardant Chemicals and Fire Suppressant Foam on North Proceedings of the North Dakotak Academy of Phos-Chek G75-F N/A N/A Larson Dl and Newton WE 1996 Dakota Prairie Vegetation. Plants Science, 50: 137-144

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Environmental Persistence and Toxicity of Fire-Retardant Chemicals, Fire-Trol GTS-R and Phos- Fire-Trol GTS-R and Phos-Chek D75- Check D75-R N/A N/A Little EE and Calfee RD R to Fathead Minnows Fish Zooplankton Responses to Acidification: A Review of Laboratory UNKNOWN N/A N/A Locke A 1990 Bioassays Zooplankton Water, Air and Soil Pollution, 60 :135-148 In vitro cytogenic testins using sister chromatid exchange and Chinese chromosome aberration endpoints in hamster (CHO Abstracts of the eighteenth annual meeting of Chlorinated trisodium phosphateN/A N/A Loveday KS et al 1986 CHO cells. cells)? the evironmental mutagen society. In vitro cytogenic testins using sister chromatid exchange and Chinese chromosome aberration endpoints in hamster (CHO Abstracts of the eighteenth annual meeting of Chlorinated trisodium phosphateN/A N/A Loveday KS et al 1987 CHO cells. cells)? the evironmental mutagen society.

Chromosome Aberration and Sister Chromatid Exchange Tests in Chinese Chinese Hamster Ovary Cells In hamster CHO Environmental and Molecular Mutagenesis, 13: Chlorinated trisodium phosphateN/A N/A Loveday KS et al 1989 Vitro: II. Results With 20 Chemicals cells 60-94 Clinical principles of environmental health : Not an IP paper N/A N/A Lowe J and Sullivan JB Jr 1992 Hazardous materials toxicology N/A 1053-62 Lethat effects of 1888 chemicals Ammmonium upon four species of fish from Forest, wildlife and range experiment station. flurophosphate N/A N/A MacPhee C and Ruelle R 1969 Western North America Fish Bulletin No. 3 Study of the mutagenicity of metal Inorganic phosphates not derivatives with Salmonella investigated N/A N/A Marzin DR and Phi HV 1985 typhimurium TA102. Bacteria Mutation Research. 155: 49-51 Acute and chronic toxicity of No IP substances ammonia to freshwater fish: a site Environmental toxicology and chemistry, 5(5): investigated N/A N/A Mayes MA 1985 specific study fish 437-442 Fire-Trol GTS-R, Fire-Trol Acute Toxicity of Fire Control LCG-R, Phos-ChekD75-F, McDonald SF, Hamilton chemicals to Daphnia magna Phos-Chek WD-881 and SJ, Buhl KJ and Heisinger (Straus) and Selenastrum Ecotoxicology and environmental safety, 33: Silv-Ex. N/A N/A JF. 1996 capricornutum (Printz) Daphnia, algae 62-72

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Fire-Trol GTS-R, Fire-Trol LCG-R, Phos-ChekD75-F, McDonald SF, Hamilton Acute Toxicty of Fire-Retardant and Phos-Chek WD-881 and SJ, Buhl KJ and Heisinger Foam-Suppressant Chemicals to Environmental Toxicology and Chemistry, Silv-Ex. N/A N/A JF. 1997 Hyalella Azteca (Suassure) Amiphod 16(7): 1370-1376 UNKNOWN N/A N/A Menzel 1932 Sieg alkaliphosphates N/A Ztsc hr. Elektrochem. 58(5): 283-299

Polyphosphate and Reactions and availability of banded superphosphate (fertilisers) N/A N/A Miner G and Kamprath E 1971 polyphosphate in field studies N/A Soil sci Soc Am J. 35: 927-930 Morris R, Taylor EW, Cambridge University Press. ISBN: 978-0-521- N/A N/A N/A Brown DJA and Brown JA 1987 Acid Toxicity and Aquatic Animals. 33435-8 Mutagenic effects of some metal Inorganic phosphates not compounds on cultured mammalian investigated N/A N/A Nishimura M and Umeda M 1978 cells. Unknown source A Report of Research on the Behaviour and Impact of Chemical Phos-Chek XA N/A N/A Norris LA et al 1978 Fire Retardents in Forest Streams N/A N/A Conditions for detecting the Sodium ammonium mutagenicity of divalent metals in Environmental and Molecular mutagenesis. 19: phosphate N/A N/A Pagano DA and Zeiger E 1992 Salomnella typhimurium. bacteria 139-146

Inorganic phosphates not Chromosome damage in human cell investigated N/A N/A Paton GR and Allison AC 1972 cultures induced my metal salts. Mutation research. 16(3): 332-336 The effect of 0.025 and 0.0125 dietary sodium fluoride on the rat N/A: sodium fluoride N/A N/A Pindborg J 1957 kidney Rat Odont Rev. 8: 331-334 Abstr Pap Am Chem Soc 188th American Relative safety of common fertilizer Chemical Society Meeting Piladelphia Aug 26- phosphate carriers N/A N/A Plate H and Mathews D 1984 materials for planter application N/A 31 1984

The systems zinc oxides - phosphoric oxide - water and manganous oxide- phosphoric oxide-water at zinc phosphates' N/A N/A Salmon JE and Terrey H 1950 temperatures between 25° and 100° n/a J Chem Soc. Unknown vol: 2913-2924 Toxicity Evaluation of Superphosphate on Some Aquatic zooplankton, Invertebrates Exposed to worm, larvae superphosphate N/A N/A Sarkar SK 1989 Temperature. and molluscs J Environ Biol, 11(2): 97-100

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium hexametaphosphate : Initial submission: rabbit eye irritant ESCOFOS (not applicable classification study with sodium to SHMP - substance is a Saylor JF and Kamienski hexametaphosphate with cover letter Stauffer Western RC NTIS OTS0545336 (T- formulation) N/A N/A FX 1971 dated 082892 Rat 1729) sodium hexametaphosphate : Initial submission: rabbit eye irritant ESCOFOS (not applicable classification study with sodium to SHMP - substance is a Saylor JF and Kamienski hexametaphosphate with cover letter Stauffer Western RC NTIS OTS0545336 (T- formulation) N/A N/A FX 1971 dated 082892 Rabbit 1729) sodium hexametaphosphate : Initial submission: rabbit eye irritant ESCOFOS (not applicable classification study with sodium to SHMP - substance is a Saylor JF and Kamienski hexametaphosphate with cover letter Stauffer Western RC NTIS OTS0545336 (T- formulation) N/A N/A FX 1971 dated 082892 Rabbit 1729) No IP substances investigated N/A N/A Schardein JL 1993 Chemically induced birth defects. N/A 2nd edition. 842-869 Effects of Fire Retardant Application on Heathland Surface-Dwelling Ant Species (Order: Hymenoptera; Family Formicidae) in Victoria Fire Retardants N/A N/A Seymour B, Collet NG 2009 Australia Invertebrates Forest Ecology Management, 257: 1261-1270 No inorganic phosphates Archives of Environmental Contamination and investigated. N/A N/A Shafer EW and Bowles WA 1985 Acute oral toxicity and repellency of 933Mice chemicals to HouseToxicology. and Deer 14:111-129 mice Shpunt SY, Belopolskii AP unknown N/A N/A & Shulgina MN 1951 unknown n/a Zh Prikl Chim. 24: 404-4 12 Aluminium N/A N/A Sjogren B and Elinder CG 1993 Alumini um N/A Nordic expert group. Arbete och Halse. 1:55-84

The effects of the absorption of fluoride. V. The chemical determination of flouride in human Smith FA , Gardner DE, soft tissues following prolonged No IP substances reported N/A N/A Leone NC and Hodge HC 1960 ingestion of fluoride at various levels Human AMA Arch. Indust. Health. 21: 330-332 Effect of calcium and phosphorus on N/A N/A N/A Spencer H 1975 fluoride metabolism in man. human J. Nutr. 105(6): 733-740.

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Effect of phosphorus on the absorption of calcium and on the Sodium glycerophosphate N/A N/A Spencer H 1978 Calcium balance in Man. human J. Nutr. 108:447-457 Tissue changes in rats lungs caused Phosphate berlinite by hydroxides, oxides and (AIPO4) N/A N/A Stacy 1958 phosphates of aluminium and iron rat J Path Bact 77: 417-426 A retrospective cohort mortality study of a phosphate fertilizer production Phosphate ore N/A N/A Stayner LM et al 1985 facility Human Arch Environ Health, 40: 133-138 Not applicable - review of Presented at the Pitman-Moore Nutrition for assays to determine Sullivan TW and Douglas Phosphorious bioassays - the Nineties Conference, Bloomington, MN, available phosphorous N/A N/A JH 1990 Developments in five decades N/A September 17, 1990. 18-

DCP (not chemical – precipitated from bone) Biological value of bone-precipitated compared to commercially dicalcium phosphate in turkey starter available forms. N/A N/A Sullivan TW et al 1994 diets. turkey Poultry Science. 73: 122-128 The dissociation of calcium Calcium aluminium aluminium phosphate, phosphate N/A N/A Taylor AW and Gurney EL 1964 CaAlH(PO4)2.6H20. N/A Soil Sci. Soc. Am J. 28:63-65 Hydrolysis of condensed phosphates condensed phosphates N/A N/A Thilo E 1955 in aqueous solution water and soil Angewandte Chemie, 67:141-185 Radiolabelled phosphate N/A N/A Tomatis 1973 Transplacental Carcinogenesis N/A WHO condensed phosphates N/A N/A Topley B 1949 Physical properties n/a Q Rev Chem Soc. 3:345-370 On the functional relationship between the pituitary gland and the Serum phosphorous N/A N/A Tornblom N 1949 parathyroids Acta Endocrinol Suppl, 4: 1-76

Ferrous and Ferric A Comparison of Ferrous and Ferric ammonium sulphate N/A N/A Underwood EJ 1938 Iron in the Nutrition of the Rat. Rat Journal of Nutrition, 16(3): 299-308 UNKNOWN N/A N/A Van Wazer JR 1954 ? N/A J Phys Chem. 58: 739 orthophosphate, pyro- and Van Wazer JR, Griffith EJ Analysis pH titration of soluble tripolyphosphate mixtures N/A N/A and McCullough JF 1954 phosphates and their mixtures Anal. Chem. 26: 1755 – 1760 The effect of the solution Ca / P ratio Verbeeck RMH and on the kinetics of dissolution of Octocalcium phosphate N/A N/A Devenyns JAH 1990 octocalcium phosphate. Journal of Crystal Growth. 102: 647-657

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Acute toxicity and skin corrosion data No IP substances for some organic and inorganic Toxicology and Applied Pharmacology. investigated N/A N/A Vernot EH et al 1977 compounds and aqueous solutions. Rabbit, rat 42:417-423 The mechanism of the hydrolysis of sodium cyclo-triphosphate, polyphosphates. VI. The effect of sodium cyclo- cations on the hydrolysis of cyclo-tri- Bulletin of the Chemical Society of Japan. trimetaphosphate n/a n/a Watanabe M 1982 and cyclo-tetraphosphates N/A 55(12): 3766-3769

Watanabe W, Suzumori H, The synthesis and decomposition of Bulletin of the Chemical Society of Japan. 35: calcium tetraphosphate N/A N/A Maeda M and YamadaT 1980 calcium tetraphosphate N/A 2663-2665 sodium and potassium The alkali orthophosphates. Phase phosphates N/A N/A Wendrow B & Kobe KA 1954 equilibria in aqueous solution. n/a Chem Rev. 54: 891-924 UNKNOWN N/A N/A Wenger P 1911 Tables N/A Annuelles. 2: 411 -413

Chemonics Fire Foam 103 Monsanto Phos-Chek WD 861, 881 Wormal SILV-EX Prepared by Norecol Environmental Angus Forexpan Consultants Ltd on behalf of Manager, Fire 3m FB 100 Toxicological Review of Fire Fighting Management Forest Protection Branch British N/A N/A Wheeler IP 1989 Foams. N/A Columbia. Ferric Iron Absorption in Rats: Relationship to Iron Status, Endogenous Sulfhydryl and Other Wien EM and Van Campen Redox Components in the Intestinal ferric chloride N/A N/A DR 1991 Lumen Rat Journal of Nutrition 121(6): 825-831 Salmonella Mutagenicity tests: IV. chlorinated trisodium Results from the testing of 300 Environmental and Molecular Mutagenesis. 11 phosphate N/A N/A Zeiger E et al 1988 Chemicals Salmonella (suppl 12) 1-158 Kinetics and mechanisms of octacalcium phosphate N/A N/A Zhang J 1992 octocalcium phosphate at 37°C. J. Phys. Chem. 96: 5478-5483 Inorganic polyphosphate: toward making a forgotten polymer polyphosphate' n/a n/a Kornberg A 1995 unforgettable n/a J. Bacteriol. 1n(3):491-496. various n/a n/a Deshpande SS 2002 Handbook of Food Toxi cology various n/a Bone and Soft Tissue Changes with The Journal of Clinical Investigation. 51: 2834- unknown n/a n/a Laflamme GH & Jowsey J 1972 Oral Phosphate Supplements dogs 2840

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

J. L. Montgomery, J. R. Blanton, Jr., R. L. Horst, M. L. Galyean, K. J. Morrow, Effects of biological type of beef Jr., D. B. Wester and M. F. steers on vitamin D, calcium, and phosphorus' n/a n/a Miller 2004 phosphorus status cows J Anim Sci 2004. 82:2043-2049. various n/a n/a NRC 2005 NRC Mineral tolerance of animal s various n.a The effect of calcium source and no IP substance tested n/a n/a Charles OW 1975 level on egg shell quality hens Poultry Science. 54: 1744

joyce Jr, Pierce KR, clincial study of nutritional secondary Journal of the American vetinary medical no IP substance tested n/a n/a Romane WM and Baker JM 1971 hyperparathyroidism in horses. horse association. 151(12): 2033-2043 Die antimikrobielle Wirkung von Polyphosphaten. Ph.D. thesis. Technical University of Munieh. various polyphosphates n/a n/a Maier, S. K. 1999 Freising, Germany. n/a TOC( SUPPL: *) Effect of polyphosphates оп lactic Radkowski, М. and Kafel, acid bacteria of processing unknown n/a n/a S. 1985 importance unknown Med Weter 400:328-329 Effect of High Levels of Inorganlc Phosphate on Aquatic Organisms ln Gov. Rep. Announce. Index (U.S) NTIS inorganic phosphate' n/a n/a Strange, J. R. 1977 Phosphate-Rlch Environments unknown PB263290. 77(9):181 Secondary Metabolism: Control by Temperature and inorganic Developments in Industrial Microbiology. various n/a n/a Weinberg ED 1974 phosphate n/a Handbook. Chap 8 CRCF phosphates as food various n/a n/a Ellinger RH 1972 ingredients n/a Handbook Mutagenic Evaluation of Compound Sodium Ferric FDA 73-82 010045871 Sodium Ferric Yeast and Pyrophosphate N/A N/A Brusick D 1975 Pyrophosphate Bacteria NTIS Teratologic evaluation of FDA 73-82 ferric sodium ferric sodium pyrophosphate in mice pyrophosphate N/A N/A Brusick D 1975 and rats. mice and rats NTIS concentrated super Evaluation of phosphated egg shell phosphate, diammonium Struwe FJ, Sullivan TW and fertilizer phosphates in turkey phosphate n/a, 18 N/A and Kuhl HJ 1976 starter diets1,2,3 turkey Poultry Sci. 55:1691-1699 Various Lide D R. CRC Handbook of chemistry and Various Various 2009 physics N/A CRC Handbook of chemistry and physics

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Studies on the biological value of various various various Gillis MB et al 1954 inorganic phosphates. N/A J. Nutr. 52:115-125. Hydrolysis of condensed phosphates polyphosphate' during aerobic biological sewage 'orthophosphate' Various Various Finnstein M and Hunter J 1967 treatment. microbes Water Research, Pergamon Press, 1: 247-254 Hydrolysis of condensed phosphates pyrophosphate, during aerobic biological sewage tripolyphosphate various various Finstein MS and Hunter JV 1967 treatment. N/A Water Research, Pergamon Press, 1: 247-254 Averbuch Pouchot MT and various various various Durif A 1991 Crystal chemistry of oligophosphates N/A Annu. Rev. mater. Sci. 21:65-92 Averbuch-Pouchot MT and various various various Durif A 1996 Topics in Phosphate Chemistry N/A N/A

The Merck Index, An Encyclopaedia Twelfth Edition Merck & Co., Inc. Whitehouse Various VARIOUS Various Budavari S et al 1996 of Chemicals, Drugs and Biologicals Station, NJ. Crystal Chemistry of Condensed various various various Durif A 1995 Phosphates. N/A Plenum Press, New York. various Ebel JP Action Physiologique et Toxicologique des Phosphates Various various 1958 Condensés. Impremerie Nationale J.P.831041 : 57-97 The utilization by the Chick of various various various Gillis MB et al 1949 phosphorus from different sources. chick J. Nutr. 35(2):195-207

GRAS (generally recognised as safe) Franklin Institute Research Laboratories 806- Various various Various GRAS 1973 food ingredients - Phosphates. C3378-01-7301. Various Various n/a Lewis RJ Lewis – Sax Dangerous Pro perties Volume 18

Food Antioxidants. technological, various various various Madhavi DL, et al 1996 toxicological and health perspectives N/A N/A various various various Mellor JW 1912 Modern Inorganic Chemistry N/A N/A Utilization of phosphorus from Motzok I, Arthur D and various phosphate supplements in various various various Branion HD 1956 chicks chicken Poultry Sci. 35: 627-649 Nonenzymic hydrolysis at phosphate Various phosphates Various Various osterheld 1972 tetrahedra N/A

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Solubilities of Inorganic and Metal Organic Compounds. A Compilation of Quantitative Solubility Data from Third Edition, Volume 1, New York, D. Van Various substances various various Siedell A 1940 the Periodical Literature. N/A Nostrand Company Inc Dritter Band. Wassrige Lusung und sodium phosphates' various various Thomsen J 1888 N/A hydratbildung Structure and properties of the condensed phosphates. X. general various various various Van Wazer JR 1955 structural theory N/A J Am Chem Soc, 77: 6140-6144 Structure and properties of the condensed phosphates. I. some general considerations about various various various Van Wazer JR 1950 phosphoric acids N/A J Am Chem Soc, 72(2): 639-644 Structure and properties of the condensed phosphates. II. A theory of the molecular structure of sodium various various various Van Wazer JR 1950 phosphate glasses N/A J Am Chem Soc 72(2): 644-647

Existence of ring phosphates higher various various various Van Wazer JR 1956 than the tetrametaphosphate N/A J Am Chem Soc 78: 1772 Toxicological evaluation of some extraction solvents and certain other FAO Nutrition Meetings Report Series No. 48A. Various Various N/A WHO 1970 substances Various WHO/FOOD ADD/70.39 tripolyphosphate. Hydrolysis of condensed phosphates 'pyrophosphate' Various Various Shannon JE and Lee GF 1966 in natural waters N/A Air & Wat. Pollut. Int. J 10, 735-756 Food additives in Europe 2000 - status of safety assessments of food additives presently permitted in the Various Various N/A Anon ~2000 EU. Various Food additives in Europe 2000 Bibra Toxicology Advice Phosphoric Acid and Common Various various Various and Consulting 1993 Inorganic Phosphates various Toxicity Profile. The structural chemistry of Various phosphates various various Corbridge DEC 1974 phosphorus. N/A Elsevier Scientific Publishing Company.

Phosphates; proposed affirmation of and deletion from GRAS status as Various Various Various Federal Register 1985 direct and human food ingredients. rats Vol 44, No.10, 244

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Http://www.codexalimentarius.net/gsfaonline/gr GFSA Online Food Additive Group oups/details.html?id=18&lang-en Various various Various GFSA 2008 Details for Phosphates. n/a Evaluation of the health aspects of Federation of American Societies for Various Various Various Jelleff Carr C. 1975 phosphates as food ingredients. N/A Experimental Biology. PB262651.

Hawley's Condensed Chemical Hawley's condensed chemical dictionary, 15th Various various Various Lewis RJ 2007 Dictionary N/A edition. Nonenzymic hydrolysis at phosphate Various various various Osterheld RK 1972 tetrahedral. N/A WHO IPCS INCHEM INTERNATIONAL PROGRAMME ON Toxicological evaluation CHEMICAL SAFETY WORLD food additives JECFA no HEALTH ORGANIZATION 17 TOXICOLOGICAL EVALUATION OF CERTAIN VETERINARY DRUG RESIDUES IN FOOD WHO FOOD Various Various Various 1982 ADDITIVES SERIES 17. 1982. effect of single superphosphate fertiliser on survival and respiratory dynamics of Nile Tilapia, Oreochromis niloticus Single superphosphate Omoregie E, Ajima MNO, (Actinopterygh: Acta Ichthyologica et piscatoria. 39(2): 103- (SSP) Keke RI and Wieski K 2009 perciformes:cichildae) Fish 110 effects of phosphorous supply on Abdolzadeh A, Wang X, growth, phosphate concentration and No IP substance - refers to Veneklaas EJ and Lambers cluster-root formation in three Phosphate only H 2010 Lupinus species plants Annals of Botany. 105:365-374

Dietary and genetic evidence for No IP substance - refers to Ohnishi M and Razzaque phosphate toxicity accelerating Phosphate only MS 2010 mammalian aging mice The FASEB Journal. Responses of Dairy Cows Fed Alfalfa De Boer G, Buchanan- Silage Supplemented with monoammonium Smith JG, Macleod GK & Phosphorus, Copper, Zinc, and phosphate Walton JS 1981 Manganese cows J Dairy Sci 64:2370-2377

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Manganese phosphate (hereaulite) Mn5(PO4)2[PO3(OH)]2.4H Physical and Chemical 2O TESTED AS PART OF Characterization of Mn A MIXTURE CONTAINING Linda A. Beaupre, Fariba Phosphate/Sulfate Mixture Used in MANGANESE SULPHATE 34 18718-07-5 Salehi, Joseph Zayed 2004 an Inhalation Toxicology Study n/a Inhalation Toxicology, 16:231–244, 2004 Manganese phosphate' Blumberg H, Shelling DH, The production of manganese rickets identity not defined 33,34,35 Jackson DA 1938 in rats rat The journal of nutrition, 16(3): Diffraction Patterns and Solubility Products of Several Divalent manganese hydrogen F. W. BOYLE, JR., AND Manganese Phosphate phosphate 35 51349-94-1 W. L. LiNDSAY 1985 Compounds n/a SOIL SCI. SOC. AM. J., VOL. 49, PG761-767 manganese hydrogen F. W. BOYLE, JR., AND Manganese Phosphate Equilibrium phosphate 35 51349-94-1 W. L. LINDSAY 1986 Relationships in Soils n/a SOIL SCI. SOC. AM. J., VOL. 50,

David C. Dorman; Karrie A. Brenneman; Anna M. OLFACTORY TRANSPORT: A McElveen; Sean E. Lynch; DIRECT ROUTE OF DELIVERY OF manganese hydrogen Kay C. Roberts; Brian A. INHALED MANGANESE Journal of Toxicology and Environmental phosphate 35 51349-94-1 Wong 2002 PHOSPHATE TO THE RAT BRAIN rat Health, Part A, 65: 20, 1493 — 1511 Influence of Particle Solubility on the David C. Dorman, Melanie Delivery of Inhaled Manganese F. Struve, R. Arden James, to the Rat Brain: Manganese Sulfate Marianne W. Marshall, Carl and Manganese Tetroxide U. Parkinson, and Brian A. Pharmacokinetics Following Toxicology and Applied Pharmacology 170, No IP substances tested Wong 2001 Repeated (14-Day) Exposure rat 79–87 Glutamate/Aspartate Transporter (GLAST), Taurine Transporter and Matallothionein mRNA Levels are differentially altered in astrocytes exposed to manganese chlroide, Cell cultures manganese phosphate' Erikson KM, Shuber RL , manganese phosphate or derived from rat (MnPO4) 34 18718-07-5 Aschner M 2002 manganese sulphate. brains NeuroToxicology 23 281-288 Manganese Inhalation by Rhesus Erikson, K.M., Dorman, Monkeys is Associated with Brain No IP substances tested - D.C., Lash, L.H., Aschner, Regional Changes in Biomarkers of MnSO4 M. 2007 Neurotoxicity Rhesus Monkey Tox Sci. 97:459-466.

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Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional No IP substances tested - Erikson KM, Dorman DC, changes in biomarkers of MnSO4 Lash LH and Ashner M 2008 neurotoxicity Rhesus Monkey NeuroToxicology 29 (2008) 377–385 Manganese-phosphate reactions in aqueous systems and the effects of applications of monocalcium phosphate on the availablity of trimanganese manganese to oats in an alkaline fen bis(orthophosphate) 33 14154-09-7 Heintze SG 1968 soil Plant and Soil XXIX, no. 3

Manganese phosphate Fariba Salehi, Daniel Bioaccumulation and locomotor (hereaulite) Krewski, Donna Mergler, effects of manganese Mn5(PO4)2[PO3(OH)]2.4H Louise Normandin, phosphate/sulfate 2O TESTED AS PART OF Greg Kennedy,Suzanne mixture in Sprague-Dawley rats A MIXTURE CONTAINING Philippe, and Joseph following subchronic (90 days) Toxicology and Applied Pharmacology 191 MANGANESE SULPHATE 34 18718-07-5 Zayeda, 2003 inhalation exposure Rat (2003) 264–271

Manganese phosphate (hereaulite) Fariba Salehi, Louise Mn5(PO4)2[PO3(OH)]2.4H Normandin, Daniel Neuropathology, tremor and 2O TESTED AS PART OF Krewski, Greg Kennedy, electromyogram in rats exposed to A MIXTURE CONTAINING Suzanne Philippe and manganese phosphate/sulfate MANGANESE SULPHATE 34 18718-07-5 Joseph Zayed 2006 mixture Rat J. Appl. Toxicol. 2006; 26: 419–426 manganese phosphate' Manganese-Phosphate Solubility (MnPO4) 34 18718-07-5 A. P. Schwab 1989 Relationships in an Acid Soil n/a Soil Sci. Soc. Am. J. 53:1654-1660 (1989).

MANGANESE TOXICITY IN PASTURE LEGUMES I. EFFECTS No IP substances tested - Truong NV, Wilson GL and OF CALCIUM AND PHOSPHORUS MnSO4 Andrew CS 1971 LEVELS IN THE SUBSTRATE n.a Plant and Soil 34, 309-330 (1971)

Czuba M, Zajic A, Effects of sodium phosphate loading Poprzecki S, Cholwea J, on aerobic power and capacity in off Trisodium phosphate 4 7601-54-9 Woska S 2009 road cyclists. human Journal of Sports Science and Medicine

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Expert group on vitamins EVM UK Expert Group Review of various and minerals Secretariat 2003 Phosphorus N/A EVM Review EFSA: Scientific opinion on the safety of ferrous ammonium phosphate as a source of iron added for nutritional purposes to foods for the general population (including ferrous ammonium food suplements) and to foods for phosphate N/A 10101-60-7 EFSA particular nutritional uses. VARIOUS The EFSA Journal 2010; 8(5):1584 Corrosion of metals by phosphoric Industrial and Engineering Chemistry. (23)2. phosphoric acid 48 7664-38-2 Kosting PR and Heins C acid metals pg 140-150 various various Lang K. et al 1958 Condensed Phosphates in Foods N/A Textbook Bouchard MF, Sauve S, Beabeau B, Lengrand M, Brodeur ME, Bouffard T, Intellectual impairment in school-age manganese from all Limoges E, Bellinger DC children exposed to manganese from Environmental Health Perspectives. 119(1) sources 34 n/a and Mergler D drinking water Children 138-143 monocalcium phosphate, dicalcium phosphate, 7758-23-8, Structure and chemistry of the tricalcium phosphate , 7757-93-9, apatites and other calcium hydroxyapatite 21,22,24 1306-06-5 Elliot JC 1994 orthophosphates N/A Studies in inorganic chemistry Sodium fluoride-induced chromosome aberrations in different stages of the cell cycle: a proposed Aardema MJ, Gibson DP & mechanism Mutation Research, 223 (1989) 191-203 sodium fluoride n/a n/a LeBoeuf A 1989 Cells disodium fluorophosphate Baylink DJ, Duane PB, Monophosphate physiology: the (SFP) 47 10163-15-2 Farley SM & Farley JR 1983 effects of fluoride on bone bones Caries Research. 17(1): 56-57 Effect of sodium monophosphate and disodium fluorophosphate calcium on bone density and fracture (SFP) 47 10163-15-2 Broll H, Peichi P, Wlifert H 1990 rate in osteoporosis n/a Lancet. 8: 1446-1447 Histological differences in bones of rats treated with sodium fluoride (NaF) and sodium disodium fluorophosphate Brun LR, Roma SM, Perez monofluorophosphate (MFP) (SFP), sodium fluoride 47 10163-15-2 F & Rigalli A 2009 rat Bone

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Results and conclusions of the Bucher JR, Hejtmancik MR, national toxicology program's rodent Toft JD, Persing RL, Eustis carcinogenicity studies with sodium Int. J. Cancer: 48, 733-737 sodium fluoride n/a n/a SL & Haseman JK 1991 fluoride rats, mice

Delmas PD, Dupuis J, Treatment of Vertebral Osteoporosis disodium fluorophosphate DuBoeuf F, Chapuy MC & with Disodium Monofluorophosphate: Journal of bone and mineral research. 5(1). (SFP), sodium fluoride 47 10163-15-2 Meunier PJ 1990 Comparison with Sodium Fluoride human 143-147 Dunipace AJ, Zhang W, Genotoxicity of fluoride in mouse Noblitt TW, Li Y & Stokey sperm morphology and micronucleus sodium fluoride n/a n/a GK 1989 studies mouse Journal of Dental Research. 68:334 Relationship between fluoride in the drinking water and the plasma fluoride - unknown source n/a n/a Ekstrand J 1978 fluoride concentration in man. human Caries Research. 12: 123-127 disodium fluorophosphate (SFP) 47 10163-15-2 Ericsson Y 1967 Biological splitting of PO3F ions N/A Caries Research. 1: 144-152 Broadus AE, Magee JS, A detailed evaluation of oral Mallette LE, Horst RL, phosphate therapy in selected oral phosphate' - not Lang R, Jensen PS, patients with primary Journal of Clinical Endocrinology and specified ? n/a Gertner JM & Baron R 1983 hyperparathyroidism Human Metabolism. 56(5)

sodium fluoride and chromosome damage (in vitro human lymphocyte sodium fluoride n/a n/a Albanese R 1987 and in vivo micronucleus assays) n/a mutagenesis. 2(6): 497-499 Bone morphometry and differences in bone fluorine containing disodium fluorophosphate compounds in rats treated with NaF (SFP), sodium fluoride 47 10163-15-2 Brun LR, Pera LI & Rigalli 2010 and MFP Rat Biomedicine & Pharmacotherapy (64)1-6

Caries Research: Monofluorophosphate Perspectives. disodium fluorophosphate The compound and its past, present (SFP) 47 10163-15-2 Gron P and Ericsson Y 1983 and future applications. various Caries Research. Vol 17, supplement 1 No IP substances: Clement Internation Toxicological profile for fluorides, Agency for Toxic Substances and Disease Fluorides Corporation 1993 hydrogen fluoride and fluorine various Registry. U.S public health service. disodium fluorophosphate Reaction of monofluorophosphate (SFP) 47 10163-15-2 Duff EJ 1983 with apatitic substrates N/A Caries Research 17(1):77-90 disodium fluorophosphate Monofluorophosphate physiology: (SFP) 47 10163-15-2 Ericsson Y 1983 General Considerations various Caries Research 17(1): 46-55

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Comparisons of serum fluoride levels after administration of monofluorophosphate-calcium Erlacher L, Teufelsbauer H, carbonate or sodium fluoride: disodium fluorophosphate Bernecker P, Pietschmann differences in peak serum (SFP) 47 10163-15-2 P & Weissel M 1993 concentrations. Human Clinical Investigations. 72: 1082-1085 Evaluation of Eppawala rock phosphate as a phosphorus Ganegoda GAP & supplement in diets for growing Chicken and rock phosphate N/A N/A Gunaratne SP 1986 chickens and pigs pigs J. Natn. Sci. Coun. Sri Lanka. 14(2):251-260 The effect of sodium Gedalia I, Hodge HC, monofluorophosphate and sodium disodium fluorophosphate Anaise J, White WE & fluoride on bone immobilization in (SFP) 47 10163-15-2 Menczel J 1970 rats rat Calc. Tiss. Res. 5, 146-152 Hill WL, Hendricks SB, Jefferson ME & Reynolds Composition of defluorinated defluorinated phosphate DS 1937 phosphate n/a Ind. Eng. Chem., 29(11): 1299-1304 Genotoxic effects of fluoride Li Y, Heerema NA, evaluated by sister-chromatid sodium fluoride n/a n/a Dunipace AJ & Stookey GK 1987 exchange cells Mutation Research. 192: 191-201 disodium fluorophosphate Fluoride and monofluorophosphate (SFP) 47 10163-15-2 Lindahl CB 1983 analysis N/A Caries Research. 17(1): 9-20 monofluorophosphate utilisation in disodium fluorophosphate oral preparations: laboratory (SFP) 47 10163-15-2 Melberg JR 1983 observations cells Caries Research. 17(1):102-118 clastogenic activity of sodium fluoride to rat vertebrael body-derived celss in sodium fluoride N/a n/a Mihashi M, Tsutsui T 1996 culture cells Mutation Research. 368: 7-13 disodium fluorophosphate biochemistry of (SFP) 47 10163-15-2 Pearce EIF 1983 monofluorophosphate n/a Caries Research. 17(1): 21-35 treatment of postmenopausal oseoporosis with sodium monofluorophosphate: preliminary disodium fluorophosphate results of a long-term double blind proceedings of the forth international (SFP) 47 10163-15-2 Reginster JY 1993 placebo-controlled study Human symposium on oseoporosis . 452-7 Therapeutic experience with the disodium fluorophosphate combination monofluorophosphate proceedings of the forth international (SFP) 47 10163-15-2 Ringe JD, Schmidt R 1993 and calcium Human symposium on oseoporosis . 433-434

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested disodium fluorophosphate Interaction of monofluorophosphate (SFP) 47 10163-15-2 Rolla G 1983 with plaque and saliva Human Caries Research . 17(1): 91-101 disodium fluorophosphate (SFP) 47 10163-15-2 Smith FA & Hodge HC 1985 Toxicology of monoflurophosphate. rats Caries Research. 17(1): 36-45 disodium fluorophosphate (SFP) 47 10163-15-2 White WE 1983 monofluorophosphate - its beginning n/a Caries Research. 17(1): 2-8 Studies on the hydrolysis and disodium fluorophosphate absorption of monofluorophosphate Pharmacology and Therapeutics in denistry. 5: (SFP) 47 10163-15-2 Ericsson Y & Patterson C 1980 ions rats , humans 47-54 The mechanism of the disodium fluorophosphate monofluorophosphate action on n/a - human (SFP) 47 10163-15-2 Ericsson Y 1973 hydroxyapatite and dental enamel teeth Acta Odont Scand. 21:341-358 Metabolism of the complex disodium fluorophosphate Esteban L, Rigalli A & monofluorophosphate-alpha2- (SFP) 47 10163-15-2 Puche C 1999 macroglobulin in the rat rat Medicina. 59:15-156 monofluorophosphate is hydrolysed by alkaline phosphatase and mimics disodium fluorophosphate Farley JR, Tarbaux NM, the actions of NaF on skeletal n/a - in vitro (SFP) 47 10163-15-2 Lau KHW &Baylink DJ 1987 tissues, In vitro study Calcified Tissue International. 40:35-42 various forms of Giavaresi G, Fini M, Gnudi Comparison of calcitonin, monofluorophosphate - not S, Nicoli Aldini N, Rocca M, alendronate and fluorophosphate SFP n/a n/a Carpi A & Giardino R 2001 effects on ovariectomised rat bone rat Biomed and Pharmacother. 55:397-403 Glass RL, Peterson JK, Fluoride ingestion resulting from the disodium fluorophosphate Zuckerberg DA & Naylor use of a monofluorophosphate (SFP) 47 10163-15-2 MN 1975 dentrifice by children human British Dental Journal. 138:423-426 Cell cycle dependenceof cytotoxicity and clastogenicity induced by treatment of synchronized human diploid fibroblasts with sodium sodium fluoride - NaF n/a n/a Hayashi N & Tsutsiu T 1993 fluoride cells Mutation Research. 290:290-302 Preliminary investigations of the effect of sodium monofluorophosphate on salivary disodium fluorophosphate Haydon GB, Hein JW & acid production and hydroxy apatite (SFP) 47 10163-15-2 Gardner DE 1951 solubility n/a J Dent Res. 30:466

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Genetic toxicity of biomaterial. 2. DNA damaging effects of sodium fluoride and other fluoride sodium fluoride - NaF n/a n/a Kanematsu N 1985 compounds bacteria Jpn. J. Oral Biol. 27: 372-374 The Genotoxic and Cytotoxic Activities of Inorganic Fluoride in Cultured Rat Bone cells - rat bone Archives of Environmental Contamination and sodium fluoride - NaF n/a n/a Khali AM & Da'dara AA 1994 Marrow Cells marrow Toxicology. 26:60-63 sodium fluoride - NaF n/a n/a Kishi K & Tonomura A Cytogenic effects of sodium fluoride cells unknown Absence of mutagenic and Li Y, Dunipace A & Stookey antimutagenic activities of fluoride in sodium fluoride - NaF n/a n/a GK 1987 Ames Salmonella assays bacteria Mutation Research, 190: 229-236 Lack of genotoxic effects of fluoride Li Y, Dunipace A & Stookey in the mouse bone-marrow sodium fluoride - NaF n/a n/a GK 1987 micronucleus test cells - mouse J Dent Res. 66: 1687-1690 Li J, Suzuki Y, Hayashi K & The genotoxic effect of sodium sodium fluoride - NaF n/a n/a Shimizu H 1991 fluoride cells/bacteria Unknown Genotoxic evaluation of chronic fluoride exposure: sister-chromatid Li Y, Zhang W, Noblitt TW, exchange sodium fluoride - NaF n/a n/a Dunipace AJ & Stookey GK 1989 study hamsters Mutation Research, 227 :159-165 Muller P, Schmid K, Sodium fluoride-induced gastric disodium fluorophosphate Warnecke G, Setnikar I & mucosal lesions: comparison with (SFP) 47 10163-15-2 Simon B 1992 sodium monofluorophosphate Human Z Gastroenterol. 30:252-254 The effect of sodium fluoride and sodium monofluorophosphate on the disodium fluorophosphate Nordenberg D, Simkin A, mechanical properties of normal and (SFP) 47 10163-15-2 Gedalia I & Robin G 1971 osteoporotic rat bone. rat Isr J. Med. Sci . 7(3): 529-531 National Toxicology Program. US Department of Heatlh and Human Toxicology and carcinogenesis Services. Public Health studies of sodium fluoride (CAS No. Service. National Institute 7861-49-4) in F344/N rats and sodium fluoride - NaF n/a n/a of Health. 1990 B6c3F1 mice (drinking water studies) rats, mice NTP TR-393

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Collins T.F.X, Sprando R.L, Black T.N, Shackelford M.E, Bryant M.A, Olejinik N, Ames M.J, Rorie J.I & Multigenerational evaluation of sodium fluoride - NaF n/a n/a Ruggles D.I 2001 sodium fluoride in rats rats Food and Chemical Toxicology 39, 601-613 Sprando RL, Collins TFX, Testing the potential of sodium Black TN, Rorie J, Ames fluoride to affect spermatogenesis in sodium fluoride - NaF n/a n/a MJ & O'Donnell M 1997 the rat RATS Food and Chemical Toxicology. 35:881-890

Collins T.F.X, Sprando R.L, Black T.N, Shackelford M.E, Bryant M.A, Olejinik Developmental toxicity of sodium N, Ames M.J, Rorie J.I & fluoride measured during multiple sodium fluoride - NaF n/a n/a Ruggles D.I 2001 generations RAT Food and Chemical Toxicology 39, 867-876 Developmental toxicity of sodium fluoride (CAS #7681-49-4) in sodium fluoride - NaF n/a n/a Heindel J 1994 Sprague-Dawley (CD) rats RAT NTIS PB95110193 Developmental toxicity of sodium fluoride (CAS #7681-49-4) in New sodium fluoride - NaF n/a n/a Heindel J 1993 Zealand White (NZW) rabbits rabbit NTIS PB94-142684 Collins, TFX, RL Sprando, ME Shackelford, TN Black, MJ Ames, JJ Welsh, MF Balmer, N. Olejnik & DI Developmental toxicity of sodium sodium fluoride - NaF n/a n/a Ruggles 1995 fluoride in rats rats Food & Chemical Toxicity. 33(1): 951-960 Bioavailability of Fluoride Administered as Sodium Fluoride or disodium fluorophosphate Rigalli A, Morosano M & Sodium Monofluorophosphate to Arzneim Forsch / Drug Research. 46(I): 531- (SFP) 47 10163-15-2 Puche RC 1996 Human Volunteers human 533 Gastric and Intestinal Absorption of disodium fluorophosphate Rigalli A, Cabrerizo A, Monofluorophosphate and Fluoride in (SFP) 47 10163-15-2 Beinlich AD & Puche RC 1994 the Rat rat Arzneim Forsch / Drug Research. 44: 651-655 Comparative Study of the Effect ofSodium Fluoride and Sodium disodium fluorophosphate Rigalli A, Alloatti R, MonoJluorophosphate on Glucose (SFP) 47 10163-15-2 Menoyo I & Puche RC 1995 Homeostasis in the Rat rat Arzneimittelforschung. 45(3): 298-292 disodium fluorophosphate Rigalli A, Esteban L, Pera L Binding of Monofluorophosphate to (SFP) 47 10163-15-2 & Puche RC 1997 alpha2-Macroglobulin and C3 n/a Calcified tissue international. 60:86-89

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In postmenopausal osteoporosis the Rigalli A, Pera L, Morosano bone increasing effect of disodium fluorophosphate M, Masoni A, Bocanera R, monofluorophosphate is not (SFP) 47 10163-15-2 Tozzini T & Puche RC 1999 dependent on serum fluoride human Medicina. 59:157-161 Pharmacokinetic Differences between Sodium Fluoride and Sodium Monofluorophosphate and Rigalli A, Ballina JC, Comparative Bone Mass Increasing disodium fluorophosphate Beinlich AD, Alloatti R & Activity of Both Compounds in the (SFP) 47 10163-15-2 Puche RC 1994 Rat rat Arzneim Forsch/Drug Res. 44(I).6:762766 physiologie et pharmacocinetique du SFP-calcium carbonate monofluorophosphate disodique- complex n/a n/a Rouveix B, Faurisson F 1988 carbonate de calcium human Lettre du Pharmacologue. 2: 1-4 Monofluorophosphate Increases Serbet JL, Richard P, Lumbar Bone Density in Osteopenic disodium fluorophosphate Mennecier I, Bisset JP & Patients: A Double-Masked (SFP) 47 10163-15-2 Loeb G 1995 Randomized Study human Osteoporosis Int 5:108-114 Spak CJ, Ekstrand J & Bioavailability of Fluoride Added to sodium fluoride - NaF n/a n/a Zyberstein D 1982 Baby Formula and Milk human Caries Res. 16: 249-256 Cytotoxicity, chromosome aberrations and unscheduled DNA synthesis cultured human diploid Tsutsui T, Suzuki N, fibroblasts induced by sodium sodium fluoride - NaF n/a n/a Ohmori M & Maizumi H 1984 fluoride cells Mutation Research, 139 193-198 Induction of unscheduled DNA Tsutsui T, Ide K & Maizumi synthesis in cultured human oral sodium fluoride - NaF n/a n/a H 1984 keratinocytes by sodium fluoride cells Mutation Research, 140: 43-48 Tsutsui T, Tanaka Y, No increases in chromosome Matsudo Y, Uehama A, aberrations in human diploid Someya T, Hamaguchi F, fibroblasts following exposure to low Yamamoto H & Takahashi concentrations of sodium fluoride for sodium fluoride - NaF n/a n/a M 1995 long times cells Mutation Research 335: 15-20 Sodium Fluoride-induced Morphological and Neaplastic Transformation, Chromosome Aberrations, Sister Chromatid Exchanges, and Unscheduled DNA Tsutsui T, Suzuki N & Synthesis in Cultured Syrian Hamster sodium fluoride - NaF n/a n/a Ohmori M 1984 Embryo Cells cells CANCER RESEARCH 44. 938-941.

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Van Asten P, Darroudi F, Cytogenetic effects on lymphocytes disodium fluorophosphate Natarajan AT, Terpstra IJ & in osteoporotic patients on long-term (SFP) 47 10163-15-2 Duursma SA 1998 fluoride therapy human cells Pharm World Sci. 20: 314-318

Fluoride Bioavailability from disodium fluorophosphate Villa A, Guerrero S, Disodium Monofluorophosphate (SFP) 47 10163-15-2 Cisternas P & Mockeberg F 1989 Fluoridated Milk in Children and Rats human, rats Caries Research. 23:179-183 Voroshilin SI, Plotko EG, Cytogenetic effect of inorganic hydrogen fluoride only Gatiyatullina EZ & Gileva fluorine compunds on human and cells: tested n/a n/a EA 1973 animal cells in vivo and in vitro human/animal Sov Genet. 9:492-496 disodium fluorophosphate Zeiger E, Shelby MD & Environmental and Molecular Mutagenesis (SFP) 47 10163-15-2 Witt KL 1993 Genetic toxicity of fluoride various 21:309-318 disodium fluorophosphate Clinical Studies of (SFP) 47 10163-15-2 DePaola PF 1983 Monofluorophosphate Dentifrices various Caries Res. 17 (1): 119-135 Journal of Research of then Nation Bureau of Avnimelech Y, Moreno EC Solubility and surface properties of Standards A. Physics and Chemistry. 77A. 1: hydroxyapatite 24 1306-06-5 & Brown WE 1972 finely divided hydroxyapatite n/a 149-155 calcium phosphate The phosphate of calcium. Part V. unspecified n/a n/a Bassett H 1958 Revision of the earlier space diagram n/a Journal of the Chemistry. 2949-2955 Maximizing calcium and phosphate Bouchoud L, Fonzo- content in neonatal parenteral disodium Christie C, Sadeghipour F nutrition solutions using organic Journal of Parenteral and Enteral Nutrition. hydrogenorthophosphate 3 7558-79-4 & Bonnabry P 2010 calcium and phosphate salts n/a 34(5): 542-545 Cade R, Conte M, Zauner sodium phosphate C, Mars D, Peterson J, Effects of phosphate loading on 2,3- (unspecified - states Lunne D, Hommen & diphosphoglycerate and maximal Medicine and Science in Sprots and Exercise. neutral buffered) Packer D 1984 oxygen uptake human 18(3): 263-266

Corrosion resistance of nickel- phosphoric acid 48 7664-38-2 Inco 1966 containing alloys in phosphoric acid n/a Corrosion Engieneering Bulletin. 4. 1-40 phosphoric acid 48 7664-38-2 Craig BD 1990 Handbook of Corrosion Data n/a n/a sodium dihydrogenorthophosphate The primary lesion in phophate Journal of Pathology and Bacteriology. 43(2): (MSP) 2 7558-80-7 Duguid JB 1938 nephritis rat 321-326

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A standard laboratory corrosion test phosphoric acid 48 7664-38-2 Ebling HF & Scheil MA 1951 for metals in phosphoric acid service n/a Transactions of the ASME. 975-987 Study of corrosion–erosion behaviour Guenbour A, Hajji MA, of stainless alloys in industrial phosphoric acid 48 7664-38-2 Jallouli EM and Bachir AB 2006 phosphoric acid medium n/a Applied Surface Science. 253: 2362-2366 potassium Effects of phosphorus dihydrogenorthophosphate, Goldsmith RS, Jowsey J, supplementation on serum dipotassium Dube WJ, Riggs BL, parathyroid hormone and bone Journal of clinical Endocrinology and hydrogenorthophosphate 12, 13 7778-77-0 Arnaud CD & Kelly PJ 1976 morphology in osteoporosis human Metabolism. 43(3): 523-532 tricalcium Solubility of β-Ca3(PO4)2 in the bis(orthophosphate) (ß- Gregory TM, Moreno EC, system Ca(OH)2-H3PO4-H2O at 5, Journal of Research of the National Bureau of TCP) 23 7758-87-4 Patel JM & Brown WE 1974 15, 25 and 37°C n/a standards. A. Physics and Chemistry. 78A(6):

Groves ND, Eisenbrown Corrosion of metals by weak acids Corrosion - National association of corrosion phosphoric acid 48 7664-38-2 CM & Sharfstein LR 1960 under heat transfer conditions n/a engineers. Vol 17. 173-176 tricalcium bis(orthophosphate) (ß- Studies in calcification. 1. the TCP), calcium solubility product of secondary and hydrogenorthophosphate Holt LE, Lamer VK & tertiary calcium phosphate under (DCP) 23, 22 7758.87-4 Chown HB 1925 various conditions n/a Journal of Biological Chemistry: 64: 509-1925 calcium The hydrolysis of anhydrous hydrogenorthophosphate dicalcium phosphate in (DCP), hydroxyapatite 22, 24 7757-93-9 Ishikawa K & Eanes ED 1993 hydroxyapatite n/a Journal of Dental Research. 72(2): 474-480 The solubility of bone mineral. I Levinskas GJ & Neuman solubility studies of synthetic Hydroxyapatite (HAP) 24 1306-06-5 WF 1954 hydroxylapatite. n/a Journal of chemistry. C. 59. 164-169 phosphoric acid 48 7664-38-2 Multi Alloy n/a Lab corrosion data for stainless steel. n/a Multi-alloy

Maurer JK, Cheng MC, Two-year carcinogenicity study of Journal of the National Cancer Institute. sodium fluoride n/a n/a Boysen BG & Anderson RL 1990 sodium fluoride in rats rat 82(13): 1118-1126 calcium hydrogenorthophosphate MCDowell H, Brown WE & Solubility of calcium hydrogen (DCP) 22 7757-93-9 Sutter JR 1971 phosphate. Ion-pair formation. n/a Inorganic Chemistry. 10(8):1638-1643 Adsorption on and surface chemistry hydroxyapatite 24 1306-06-5 Misra DN 1982 of hydroxyapatite n/a textbook: Plenum Press

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested calcim Preparation of octacalcium hydrogenorthophosphate, phosphate by the tricalcium phosphate 22, 23 7757-93-9 Monma H 1980 hydrolysis of α- tricalcium phosphate n/a Journal of Materials Science.15:2428-2434

Solubility of CaHPO4.2H2O and the Journal of Research of the National Bureau of calcium Moreno EC, Gregory TM & formation of ion pairs in the system Standards - A. Physics and Chemistry. hydrogenorthophosphate 22 7757-93-9 Brown WE 1966 Ca(OH)2-H3PO4-H20 at 37.5°C n/a 70(A),6: 545-553 Journal of Research of the National Bureau of Moreno EC, Gregory TM & Preparation and solubility of Standards - A. Physics and Chemistry. hydroxyapatite 24 1306-06-5 Brown WE 1968 hydroxyapatite n/a 72(A),6: 545-554 Corrosion of types 316 and 317 Stainless steel by 75% and 85% corrosion - national association of corrosion phosphoric acid 48 7664-38-2 Morgan AR 1959 phosphoric acid n/a engineers. Vol 15: 351-354 phosphate' n/a n/a Nordin EC 1989 Phosphorus n/a Journal of Food and Nutrition. 45:3. 61-75 Solubility of CaHPO4.2H2O in the Journal of Research of the National Bureau of calcium Patel PR, gregory TM & quaternary system Ca(OH)2-H3PO4- Standards. A -Physics and Chemistry. 78(A).6: hydrogenorthophosphate 22 7757-93-9 Brown WM 1974 NaCl-H2O at 25°C n/a 675-682

Letters to the editor: On the hydroxyapatite 24 1306-06-5 Pearce EIF 1988 dissolution of hydroxyapatite in acids n/a Journal of Dental Research. 67(7): 1056-1058

sodium d-fructose-1,6-diphosphate vs. sodium monohydrogenphosphate in total parenteral nutrition: a disodium comparative in vitro assessment of Journal of parenteral and Enteral Nutrition. hydrogenorthophosphate 3 7558-79-4 Prinzivalli M & Ceccarelli S 1999 calcium/phosphate compatibility n/a 23(6): 235-242 The corrosion properties of chrominum-nickel-manganese Proceedings - American Society for testing phosphoric acid 48 7664-38-2 Renshaw WG & Lula RA 1956 austenitic stainless steels n/a and Materials. 52: 866 Surface properties of alkaline earth Journal of Electroanalytical Chemistry and hydroxyapatite 24 1306-06-5 Saleeb FZ & De Bruyn PL 1972 apatites n/a Interfacial Electrochemistry. 37: 99 - 118 tricalcium Functional Aspects of Renal bis(orthophosphate) 23 7758.87-4 Sanderson PH 1958 Calcification in Rats rat Clinical Science. 18:67-79 Shyu LJ, Perez L, Zawacki The solubility of octacalcium SJ, Heughebaert JC & phosphate at 37 °C in the system octacalcium phosphate n/a n/a Nancollas GH 1983 Ca(OH)2-H3PO4-KNO3-H2O n/a Journal of Dental Research . 62: 398-400

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Takeda E, Taketani Y, Sawada N, Sato T & The regulation and function of inorganic phosphate n/a n/a Yamamoto H 2004 phosphate in the human body n/a Biofactors 21. 345-355

Effect of phosphate supplementation on the expression of the mutant Tenenhouse HS, Martel J, phenotype in murine x-linked phosphate' n/a n/a Rubin J & Harvey N 1994 hypophosphatemic rickets. mice Bone. 15(6): 677-683 Verbeek RMH, Steyaer H, Solubility of synthetic calcium hydroxyapatite 24 1306-06-5 Thun HP & Verbeek F 1980 hydroxyapatites n/a Faraday discussions. 1(76): 209-219 Corrosion and weldability studies on chromium-manganese austenitic corrosion - National Association of Corrosion phosphoric acid 48 7664-38-2 Warren D 1960 stainless steels n/a Engineers. 16: 101-112 Wier D R, Chien SH & hydroxyapatite 24 1306-06-5 Black CA 1971 Solubility of hydroxyapatite n/a Soil Science. 111(2): 107 - 112 Kinetics and mechanism of hydroxyapatite crystal dissolution in Wu MS, Higuchi WI, Fox weak acid buffers using the rotating hydroxyapatite 24 1306-06-5 JL & Friendman M 1967 disk method. n/a Journal of Dental Researc. 55(3): 496-505 Yaro AS, Wael RK & Reaction kinetics of corrosion of mild Journal of the University of Chemical phosphoric acid 48 7664-38-2 Khadom AA 2010 steel in phosphoric acid n/a Technology and Metallurgy. 45(4): 443-448 Intestinal absorption of disodium monofluorophosphate in the rat as disodium fluorophosphate Beinlich AD, Brun LRM, affected by concurrent administration (SFP) 47 10163-15-2 Rigalli A & Puche RC 2003 of calcium. rat ArzneimForschDrugRes. 53(8):584-589 Influence of milk and food on fluoride disodium fluorophosphate bioavailability from NaF and (SFP) 47 10163-15-2 Trautner K & Einwag J 1989 Na2FPO3 in man. human Journal of Dental Research. 68: 72-77 Absolute bioavailability of fluoride Van Asten P, Duursma, from disodium monofluorophosphate disodium fluorophosphate Glerum JH, FFT Ververs, and enteric-coated sodium fluoride (SFP) 47 10163-15-2 Van Rijn HJM & Van Dijk A 1996 tablets human Wur J Clinical Pharmacol. 50: 321-326 The effect of calcium on disodium monofluorophosphate absorption disodium fluorophosphate Villa A, Carrasco G, from the gastrointestinal tract of the Research Communications in Clinical (SFP) 47 10163-15-2 Valenzuela A & Garrido A 1992 rat rat Pathology and Pharmacology. 77(3): 367-373 Biavailability and pharmacokinetics glutamine of fluoride from two glutamine monofluorophosphate n/a n/a Warneke G, Setnikar I 1993 monofluorophosphate preparations human ArzneimForschDrugRes. 43(I).5:584-588

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Effects of meal on the disodium fluorophosphate pharmacokinetics of fluoride from (SFP) 47 10163-15-2 Warneke G & Setnikar I 1993 oral monofluorophosphate human Arzneim-Forsch/Drug res. 43(I).5: 590-595 Elmore KL, Hatfield JD, dissociation of phosphoric acid The journal of physical chemistry . 69(10): phosphoric acid 48 7664-38-2 Dunn RL & Jones AD 1965 solutions at 25 °C n/a 3520-3525 Corrosion Handbook. Corrosive agents and their interaction with materials. Volume 3. hypochlorites, phosphoric acid 48 7664-38-2 Kreysa G and Shutze M phosphoric acid. n/a Handbook. ISBN: 3-527-31119-X sodium tetraborate and Soucek D, Dickenson A Acute and chronic toxicity of boron to Environmental Toxicology and Chemistry, Vol. boric acid n/a n/a and Koch BT 2011 a variety of fresh water organisms various 30, No. 8, pp. 1906–1914, Association Between Oral Sodium mixture: monosodium Phosphate Bowel Preparations and phosphate and disodium Kidney Injury: A Systematic Review American Journal of Kidney Diseases, Vol 53, phosphate 2,3 n/a Brunelli SM 2009 and Meta-analysis human No 3 (March), 2009: pp 448-456 sodium phosphate' - likely Seol DC, Hong SN, Kim Change in renal function after to be a mixture of MSP and JH, Sung IK, Park HS, Lee sodium phosphate preparation for World Journal of Gastroenterology (2010) April DSP 2,3? n/a Jh and Shim CS 2010 screening colonoscopy human 28; 16(16): 2010-2016 Polyethylene glycol vs. sodium phosphate for sodium phosphate' - likely bowel preparation: A treatment arm to be a mixture of MSP and Juluir R, Eckhart G and metaanalysis of randomized DSP 2,3? n/a Imperiale TF 2011 controlled trials human BMC Gastroenterology 2011, 11:38 Acute Phosphate Nephropathy following Oral Sodium Phosphate sodium phosphate' - likely Markowitz GS, Stokes MB, Bowel Purgative: An to be a mixture of MSP and Radhakrishnan J,and Underrecognized Cause of Chronic DSP 2,3? n/a D’Agati VD 2005 Renal Failure human J Am Soc Nephrol 16: 3389–3396, 2005 Ellam T, Wilkie M, Chamerlain J, Crossman Dietary Phosphate Modulates monocalcium phosphate, D, Eastell R, Francis S and Atherogenesis and Insulin Resistance Arteriosclerosis, Thrombosis and vascular dicalcium phosphate 21, 22 7758-23-8 Chico TJA 2011 in Apolipoprotein E Knockout Mice Mice biology. 2011:31 Teratologic evaluation of FDA 71-81, (monocalcium phosphate; monocalcium phosphate monohydrate) in mice, rats and (MCP) 21 7758-23-8 Morgareidge K 1974 rabbits rats/mice NTIS PB234866 SODIUM ACID Teratologic evaluation of FDA 71-61, PYROPHOSPHATE 5 7758-16-9 Morgareidge K 1973 (sodium acid pyrophosphate) rats/mice NTIS PB22381

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Teratologic evaluation of FDA 71-46 (sodium tripolyphosphate, sodium tripolyphosphate 0 7758-29-4 Morgareidge K 1973 anhydrous) rats/mice FDABF-GRAS-075

Naddy RB, Tapp K, Identifying the cause of toxicity in an Rehner AB, Pillard DA, algal whole effluent toxicity study – monopotassium phosphate 12 7778-77-0 Schrage L 2011 An unanticipated toxicant algae Chemosphere 85 (2011) 1026–1032 Tatyana V. Kulakovskaya, Inorganic polyphosphate in industry, various inorganic Vladimir M. Vagabov, Igor agriculture and medicine: modern polypjosphates n/a n/a S. Kulaev 2010 state and outlook n/a Process biochemistry Purification and Characterization of Highly Active and Stable Polyphosphatase from Saccharomyces cerevisiae Cell yeast polyphosphates n/a n/a Andreeva NA & Okorokov 1993 Envelope (S.cerevisiae) YEAST VOL. 9: 127-1 39 Leyhausen G, Lorenz B, Zhu H, Geurtsen W, JOURNAL OF BONE AND MINERAL Inorganic linear Bohnensack R, Muller Inorganic Polyphosphate in Human RESEARCH polyphosphate WEG & Schroder HC 1998 Osteoblast-like Cells n/a - cells Volume 13, Number 5, 1998 Inorganic polymeric Muller WEG, Wang X, phosphate/polyphosphate as an Diehl-Seifert B, Kropf K, inducer of alkaline phosphatase and Schlossmacher U, a modulator of intracellular Ca2+ Inorganic polymeric Lieberwirth I, Glasser G, level in osteoblasts (SaOS-2 cells) in phosphate/polyphosphate n/a n/a Weins M & Schroder HC 2011 vitro Acta Biomaterialia 7 (2011) 2661–2671

Y. Hacchou, T. Uematsu, O. Ueda, Y. Usui, S. Uematsu, M. Takahashi, T. Uchihashi, Y. Kawazoe, T. Shiba, S. Kurihara, M. Inorganic Polyphosphate: a Possible inorganic polyphosphate n/a n/a Yamaoka and K. Furusawa 2007 Stimulant of Bone Formation n/a J DENT RES 2007 86: 893 Mammalian intestinal alkaline phosphatase acts as highly active Biochimica et Biophysica Acta 1547 (2001) inorganic polyphosphates n/a n/a Lorenz B & Schroder HC 2001 exopolyphosphatase n/a 254-261

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Lubov Ryazanova, Nadeschda Andreeva, Tatiana Kulakovskaya, The early stage of polyphosphate Airat Valiakhmetov, Valerii accumulation in Saccharomyces Yashin, Vladimir Vagabov, cerevisiae: comparative study by yeast Advances in Bioscience and Biotechnology, inorganic polyphosphate n/a n/a Igor Kulaev 2011 extraction and DAPI staining (S.cerevisiae) 2011, 2, 293-297 Y. Kawazoe, T. Shiba, R. Nakamura, A. Mizuno, K. Tsutsumi, T. Uematsu, M. Yamaoka, M. Shindoh and Induction of Calcification in MC3T3- inorganic polyphosphate n/a n/a T. Kohgo 2004 E1 Cells by Inorganic Polyphosphate n/a J DENT RES 2004 83: 613 Sex differences in kidney mineral Matsuzaki H, Katsumata S, concentrations and urinary albumin potassium Uehara M, Uehara M, excretion in rats given high- dihydrogenorthophosphate 12 7778-77-0 Nakamura K &Suzuki K 2002 phosphorus feed. rat Biosci. Biotechnol. Biochem 66(8): 1737-1739 Catalytic ability of alkaline phosphatase to promote P-O-P bond inorganic diphosphate, Yoza N, Onoue S & hydrolyses of inorganic diphosphate Chemical society of Japan. Chemistry letters. triphosphate n/a n/a Kuwahara Y 1997 and triphosphate n/a 491-492 Kaneko H, Shimada A & Short-term algal toxicity test based phosphate n/a n/a Hirayama K on phosphate uptake algae Water Research 38 (2004) 2173–2177

A comparison of the relative toxicity of bone meal and other P sources potassium used as remedial treatments to the dihydrogenorthophosphate 12 7778-77-0 Atuah L & Hodson ME 2011 earthworm Eisenia fetida earthworm Pedobiologia. Article in press, Yu Y, Wang J, Liu C, Evaluation of inherent toxicology and Zhang B, Chen H, Guo H, biocompatibility of magnesium Magnesium phosphate Zhong G, Qu W, Jiang S & phosphate Colloids and Surfaces B: Biointerfaces 76 : cement n/a n/a Huang H 2010 bone cement n/a 496–504 Assessment of Metal Availability in Condor JM, Lanno RP & Smelter Soil Using Earthworms and rock phosphate n/a n/a Basta NT 2001 Chemical Extractions earthworm J. Environ. Qual. 30:1231–1237 Evaluation of the adverse effects of two commonly used fertilizers, DAP Azizullah A, Nasir A, and urea, Richter P, Lebert M & on motility and orientation of the Environmental and Experimental Botany 74: diammonium phosphate 19 7783-28-0 Hader DP 2010 green flagellate Euglena gracilis Euglena gracilis 140– 150

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

A potential link between phosphate inorganic phosphate' in and aging—Lessons from Klotho- Mechanisms of Ageing and Development 131 : vivo n/a n/a Kuro-o M 2010 deficient mice mice 270–275

Changes in toxicity and bioavailability of lead in contaminated soils to the earthworm Eisenia fetida (Savigny Davis NA, Hodson ME & 1826) after bone meal amendments Environmental Toxicology and Chemistry, Vol. bone ash 24 68439-86-1 Black S 2002 to the soil. earthworm 21, No. 12,:2685–2691 Bioassay and use in irrigation of Gouider M, Feki M & untreated and treated wastewaters Ecotoxicology and Environmental Safety Triple Super Phosphate n/a n/a Sayadi S 2010 from phosphate fertilizer industry plants 73:932–938

Genetic induction of phosphate toxicity significantly reduces the Biochemical and Biophysical Research Ohnishi M, Kato S & survival Communications xxx (2011) xxx–xxx Article in phosphate n/a n/a Razzaque MS 2011 of hypercholesterolemic obese mice mice press. Remediation of Heavy Metal- Contaminated Soils Using Phosphorus: Evaluation potassium Maenpaa KA, Kukkonen of Bioavailability Using an Earthworm dihydrogenorthophosphate 12 7778-77-0 JVK & Lydy MJ 2002 Bioassay earthworm Arch. Environ. Contam. Toxicol. 43, 389–398 Effect of dietary phosphoric acid supplementation on acid-base Fettman MJ, Coble JM, balance and mineral and bone phosphoric acid 48 7664-38-2 Hamar DW, Norrdin RW 1992 metabolism in adult cats cat Am J Vet Res, 53(11): 2125-2135

Ibrahim S, Fisher C, El Improvement of the nutritional quality phosphoric acid, dicalcium Alaily H, Soliman H and of Egyptian and Sudanese sorghum phosphate 48, 22 7664-38-2 Anwar A 1988 grains by the addition of phosphates chicks British Poultry Science. 29: 721-728 Bioavailability of phosphorus in Potter LM, Potchanakorn various phosphate sources using M, Ravindran V and body weight and toe ash as response dicalcium phosphate 22 7757-93-9 Kornegay ET 1995 criteria chicks Poultry Science. 74: 813-820 phosphoric acid, Ravindran V, Kornegay ET, An Evaluation of Various Response monocalcium phosphate Potter LM, Ogunabameru Criteria in Assessing Biological monohydrate, dipotassium BO, Welten MK, Wilson JH Availability of Phosphorus for phosphate 48, 21, 22 7664-38-2 and Potchanakorn M 1995 Broilers chicks Poultry Science. 74: 1820-1830

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Manganese oxide, Manganese sulphate, Trimanganese tetraoxide, Dorman DC, Struve MF, Application of pharmacokinetic data Manganese phosphate Clewell HJ III and Anderson to the risk assessment of inhaled (hureaulite) (MMangP) 34 18718-07-5 ME 2006 manganese Rat, human NeuroToxicity, 27: 752-764

Dorman DC, Struve MF, Tissue manganese concentrations in Marshall MW, Parkinson young male rhesus monkeys Manganese phosphate CU, James RA, and Wong following subchronic manganese (hureaulite) (MMangP) 34 18718-07-5 BA 2006 sulfate inhalation Monkey Toxicological Sciences, 92(1): 201-210 Old age and gender influence the Dorman DC, McManus BE, pharmacokinetics of inhaled Manganese phosphate Marshall MW, James RA manganese sulfate and manganese Toxicology and Applied Pharmacology, 197: (hureaulite) (MMangP) 34 18718-07-5 and Struve MF 2004 phosphate in rats Rat 113-124 Contributions on crystal structures and thermal behaviour of anhydrous No IP substances: El-Bali B, Boukhari A, phosphates XXIX - Preparation and SrMn2(PO4)2 and Β'- Glaum R, Gerk M and structure determination of Zeitschrift für anorganische und allgemeine Mn3(PO4)2 N/A N/A Maaß K 2000 SrMn2(PO4)2 and Β'-Mn3(PO4)2 N/A Chemie, 626(12): 2557-2562

Manganese phosphate (hureaulite) (MMangP) - Gerault Y, Riou A and Phosphate hydrogénophosphate Mn5(HPO4)2(PO4)2.4H2O 34 18718-07-5 Cudennec Y 1987 hydrate de manganèse N/A Acta Cryst. C43: 1829-1830

Adequacy and consistency of animal studies to evaluate the neurotoxicity No IP substances: Mn Gwiazda R, Lucchini R and of chronic low-level manganese Rodent, Journal of Toxicology and Environmental (unspecified) N/A N/A Smith D 2007 exposure in humans primate Health, Part A, 70(7)

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Huminicki DMC and The Crystal Chemistry of the Reviews in Mineralogy and Geochemistry, 48: Various phosphates N/A N/A Hawthorne FC 2002 Phosphate Minerals N/A 123-253

Manganese phosphate (hureaulite) (MMangP) - Huréaulite Mn5(HPO4)2(PO4)2.4H2O 34 18718-07-5 Unknown 2005? Mn52+(HPO4)2(PO4)2.4H2O N/A Handbook of Mineralogy Manganese phosphate (hureaulite) (MMangP) - (Mn,Fe)5(PO4)2(HPO4)2.4 http://www.mindat.org/min-1952.html H2O 34 18718-07-5 Unknown ? Hureaulite N/A [accessed 21 Oct 2011] Manganese Massa W, Yakubovich OV A novel modification of manganese orthophosphate 33 14154-09-7 and Dimitrova OV 2005 orthophosphate Mn3(PO4)2 N/A Solid State Sciences, 7: 950-956 Hureaulite - Hureaulite, Mn52+(H2O)4[PO3(OH)]2[ Mn52+(H2O)4[PO3(OH)]2[PO4]2: Its PO4]2 34 18718-07-5 Moore PB and Takahuru A 1973 atomic arrangement N/A American Mineralogist, 58: 302-307

Normandin L, Beaupré, Manganese distribution in the brain Manganese phosphate Salehi F, St-Pierre A, and neurobehavioural changes (hureaulite) Kennedy G, Mergler D, following inhalation exposure of rats Mn5(PO4)2(PO3(OH))2.4H Butterworth RF, Philippe S to three chemical forms of 2O, 34 18718-07-5 and Zayed J 2004 manganese Rat NeuroToxicology, 25: 433-441 Manganese phosphate (hureaulite) Direct effects of manganese Mn5(PO4)2(PO3(OH))2.4H Sistrunk SC, Ross MK and compounds on dopamine and its Environmental Toxicology and Pharmacology, 2O 34 18718-07-5 Filipov NM 2007 metabolite Dopac: an in vitro study Rat 23: 286-296

No IP substances Eaton LJ, Hoyle J and King Effects of deicing salt on lowbush Canadian Journal of Plant Science, 79: 125- investigated - NaCl N/A N/A A 1999 blueberry flowering and yield N/A 128 Acute and chronic effects of sodium No IP substances and potassium on the tropical investigated - NaCl and freshwater cladoceran Pseudosida KCl N/A N/A Freitas EC and Rocha O 2011 ramosa Crustacean Ecotoxicology, 20: 88-96 No IP substances El-Deeb Ghazy MM, Effects of salinity on survival, growth investigated - NaCl and Habashy MM, Kossa FI and and reproduction of the water flea, sea water N/A N/A Mohammady EY 2009 Daphnia magna Crustacean Nature and Science, 7(11): 28-42

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Chronic effect of NaCl salinity on a freshwater strain of Daphnia magna No IP substances Martínez-Jerónimo F and Straus (Crustacea: Cladocera): A Ecotoxicology and Environmental Safety, 67: investigated - NaCl N/A N/A Martínez-Jerónimo L 2007 demographic study Crustacean 411-416

No IP substances Nielsen DL, Brock MA, Effects of increasing salinity on investigated - NaCl N/A N/A Rees GN and Baldwin DS 2003 freshwater ecosystems in Australia N/A Australian Journal of Botany, 51: 655-665

Acute and chronic toxicity of No IP substances potassium chloride (KCl) and investigated - KCl and potassium acetate (KC2H3O2) to potassium acetate Daphnia similis and Ceriodaphnia (KC2H3O2) N/A N/A Utz LRP and Bohrer MBC 2001 dubia (Crustacea; Cladocera) Crustacea Bull Environ Contam Toxicol, 66: 379-385

No IP substances The sensitivity of two cladocerans to investigated - NaCl and water quality variables: salinity and CaCO3 N/A N/A Cowgill UM and Milazzo DP 1990 hardness Crustacea Arch Hydrobiol, 120(2): 185-196 Determining ecoregional reference conditons for nutrients, secchi depth Dodds WK, Carney E and and chlorophyll a in Kansas lakes Phosphorus (unspecified) N/A N/A Angelo RT 2006 and reservoirs Crouzet P, Nixon S, Rees Phosphate (unspecified), Y, Parr W, Laffon L, orthophosphate, Bøgestrand J, Kristensen polyphosphate, P, Lallana C, Izzo G, Bokn phosphorus (unspecified), T, Bak J, Lack TJ and P2O5 N/A N/A Thyssen N (Ed) 1999 Nutrients in European ecosystems

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Phosphorus (unspecified), European Environment orthophosphate N/A N/A Agency ? Nitrogen and phosphorus in rivers Indicator fact sheet (WEU02) The global phosphorus cycle: past Phosphorus (unspecified) N/A N/A Filippelli GM 2008 present and future Elements, 4:89-95

Calcium, magnesium, sodium, potassium, ammonium, sulfate, nitrate, chloride, orthophosphate, hydrogen, bicarbonate, National Atmospheric Quality assurance report NADP/NTN hydroxide N/A N/A Deposition Program 1991 deposition monitoring

Various (Ca2+, Mg2+, Na+, Treatise on Geochemistry : Surface and K+, Cl-, SO42-, HCO3-, Global occurrence of major elements Ground Water, Weathering, and Soils, Elsevier SiO2) N/A N/A Meybeck M 2003 in rivers Ltd, ISBN: 0-08-044340-0 pages 207–223 Palaeogeography, Palaeoclimatology, The quality of rivers: from pristine Palaeoecology (Global and Planetary Change Various (S, Na, K, N, P) N/A N/A Meybeck M and Helmer R 1989 stage to global pollution Section), 75: 283-309

Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food on a request from the European Commission on Ferrous Aguilar F, Charrondiere phosphate added for nutritional Ferrous phospate 27 10045-86-0 UR, Dusemund B et al 2009 purposes to food supplements. The EFSA Journal, 951: 1-13

Reference conditions of European Phosphorus N/A N/A Solheim AL (Ed) 2005 Lakes REBECCA Project (draft paper) Hardness in drinking water; Originally published in Guidelines for drinking Background document for water quality, 2nd ed, Vol 2, Health criteria and No IP substances development of WHO guidelines for other supporting information, World Health investigated - CaC03 N/A N/A World Health Organisation 2003 drinking-water quality Organisation, Geneva, 1996 Phosphate is a specific signal for No IP substances Beck GR Jr, Zerler B and induction of osteopontin gene investigated N/A N/A Moran E 2000 expression PNAS, 97(15): 8352-8357

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Camalier CE, Young MR, Bobe G, Perella CM, Elevated phosphate activates N-ras Colburn NH and Beck GR and promotes cell transformation and Phosphate (unspecified) N/A N/A Jr 2010 skin tumorigenesis Cancer Prev, 3(3): 359-370 Low dietary inorganic phosphate Xu C-X , Jin H, Lim H-T, stimulates lung tumorigenesis Ha Y-C, Chae C-H, An G- through altering protein translation Phosphate (unspecified) N/A N/A H, Lee K-H and Cho M-H 2010 and cell cycle in K-rasLA1 mice Nutrition and Cancer, 62(4): 525-532 High dietary inorganic phosphate increases lung tumorigenesis and Phosphate (unspecified) N/A N/A Jin H et al 2009 alters Akt signaling Am J Respir Crit Care Med, 179: 59-68

A Medical Hypothesis: Phosphorus Phosphate (unspecified) N/A N/A Kapur S 2000 Balance and Prostate Cancer Cancer Investigation, 18(7): 664-669

Giovannucci E, Rimm EB, Wolk A, Ascherio A, Stampfer MJ, Colditz GA Calcium and fructose intake in Phosphate (unspecified) N/A N/A and Willett WC 1998 relation to risk of prostate cancer Cancer Research, 58: 442-447 PLoS Biology www.plosbiology.org , 5(7): 2007 1403-1405 and Biological Stoichiometry in and Stoichiometry and the New Biology: Human Cancer, PLoS ONE, www.plosone.org, Phosphate (unspecified) N/A N/A Elser J 2010 The Future Is Now 10: 1-7

Phosphate (unspecified) N/A N/A Borrell B 2010 Elemental shortage The Scientist, 24(11): 46 Monobasic sodium A combined proteome and phosphate (NaH2PO4) and 7558-80-7, microarray investigation of inorganic dibasic sodium phosphate 7558-79-4 Conrads KA, Yi M, phosphate-induced pre-osteoblast (Na2HPO4) 2, 3 Simpson KA et al 2005 cells Mol Cell Proteomics, 4: 1284-1296

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Biological stoichiometry: an Elser JJ, Nagy JD and ecological perspective on tumor Phosphate (unspecified) N/A N/A Kuang Y 2003 dynamics BioScience, 53(11): 1112-1120

Elser JJ, Kyle MM, Smith Biological stoichiometry in human PLoS ONE 2(10): e1028. Phosphorus N/A N/A MS and Nagy JD 2007 cancer doi:10.1371/journal.pone.0001028

Phosphate and the regulation of DNA Engström W and replication in normal and virus Phosphate (unspecified) N/A N/A Zetterberg A 1983 transformed 3T3 cells Biochem J, 214: 695-702

Statement of the International Food Additives Council and the European Chemical Industry Council on Jin et al "High Dietrary Inorganic Phosphate Increases Lung Tumorigenesis and Alters Akt http://www.slideshare.net/changezkn/summary- Phosphate (unspecified) N/A N/A Anon 2009 Signaling" 5553163 [accessed 29 March 2012] The rate of changes of inorganic phosphate content of Ehrlich Ascites- Phosphate (unspecified) N/A N/A Laws JO and Strickland LH 1962 Tumour cells Biochem J, 83: 84-91

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the No IP substances commission related to the tolerable investigated N/A N/A EFSA 2004 upper intake level of iron The EFSA Journal, 125, 1-34

Statement on the evaluation of a new SALP acidic and SALP study related to the bioavailability of basic 43 7785-88-8 EFSA 2011 aluminium in food The EFSA Journal, 9(5): 2157

Manganese dosimetry: species Aschner M, Erikson KM differences and implications for Manganese (unspecified) N/A N/A and Dorman DC 2005 neurotoxicity Critical Reviews in Toxicology, 35:1-32 National Institute for Occupational Safety and 1985- Health, Registry of Toxic Effects of Chemical Phosphoric acid 48 7664-38-2 Sweet DV 1986 58663. Phosphoric Acid Substances, Volume 4 Aluminium intoxication from aluminium-containing phosphate Andreoli SP, Bergstein JM, binders in children with azotemia not New England Journal of Medicine, 310(17): Aluminium hydroxide N/A N/A Sherrard DJ 1984 undergoing dialysis 1079-84

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Lee JH, Chang B-S, Ryu A 90-day subchronic toxicity study of β-calcium pyrophosphate 26 232-221-5 HS and Lee C-K 2009 beta-calcium pyrophosphate in rat Drug and Chemical Toxicology, 32(3): 277-282 American Conference of Governmental Industrial Documentation of the Threshold Limit Values Phosphoric acid 48 7664-38-2 Hygienists 2001 Phosphoric acid and Biological Exposure Indices, 7th Ed

Why aluminium phosphate is less Journal of the American College of Nutrition, Al(OH)3, AlPO4, Al 40 7784-30-7 Berthon G and Daydé SD 1992 toxic than aluminium hydroxide 11(3): 340-348

No IP substances Phalangeal metastases from investigated N/A N/A Vaezy A and Budson DC 1978 bronchogenic carcinoma JAMA, 239(3): 225-226

Aluminium speciation studies in biological fluids. Part 3. Quantitative investigation of aluminium-phosphate Daydé S, Filella M and complexes and assessment of their Orthophosphoric acid 48 7664-38-2 Berthon G 1990 potential significance in vivo Journal of Inorganic Biochemistry, 38: 241-259 245-490-9, Orthophosphoric acid, 233-782-9, Researches on the arsenates, pyrophosphoric acid, 231-633-2, phosphates and modifications of Alembic Club, London Agents Simpkin, metaphosphoric acid 45, 48, 50 219-574-0 Graham T 1833 phosphoric acid Marshall, Hamilton, Kent & Co Ltd (1904) monoammonium phosphate, diammonium Research Report No. 70: Effects of Department of Sustainability and Environment, phosphate, calcium 233-330-0, fire retardant on soils of heathland in PO Box 500, East Melbourne, Victoria 3002 phosphate 18, 19 231-987-8 Hopmans P and Bickford R 2003 Victoria (ISBN 1 74106 903 3) Comparison of molasses-alfalfa silage and phosphoric acid-alfalfa Phosphoric acid 48 7664-38-2 King WA 1943 silage as feeds for the milking cow NJ Agricultural Experiment Station Bulletin 704

Comparison of molasses-oat silage and phosphoric acid-oat silage as Phosphoric acid 48 7664-38-2 King WA 1944 feeds for the milking cow NJ Agricultural Experiment Station Bulletin 708

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Ammonium phosphate, 233-330-0, Effects of fire retardant on water diammonium phosphate 18, 19 231-987-8 Norris LA and Webb WL 1989 quality USDA Forest Service Gen Tech Rep PSW-109 Fused tricalcium Fused tricalcium phosphate as a low- phosphate, raw rock Mather RE, Pratt AD and fluorine phosphorus supplement for phosphate (P2O5) 23 231-840-8 Holdaway CW 1949 dairy cattle J Dairy Science, 32(3): 228-235 Phosphorus (unspecified), Influence of forest rangeland ammonium phosphate, management on anadromous fish aminomethylphosphonic Norris LA, Lorz HW and habitat in western North America: USDA Forest Service General Technical acid 18 233-330-0 Gregory SV 1983 Forest chemicals Report PSW-149 Phosphates and superphosphates, phosphorus and Encyclopaedia of occupational health and compounds, phosphoric safety third (revised) edition (ISBN 92-2- acid Various Various Parmeggiani L (Ed) 1983 Volume 2: L-Z 103291-4)

No IP substances Acid ingestion: toxicology and investigated N/A N/A Penner GE 1980 treatment Ann Emerg Med, 9(7): 374-379 Phosphorus and phosphorus compounds, Hazardous materials toxicology: Williams & Wilkins, 428 East Preston Street, organophosphate Sullivan JB and Krieger GR clinical principles of environmental Baltimore, Maryland 21202, USA (ISBN 0-683- insecticides Various Various (Eds) 1992 health 08025-3)

Hygienic guide series: phosphoric American Industrial Hygiene Association Phosphoric acid 48 7664-38-2 Anon 1957 acid quarterly, 18(2): 175-176 The effect of feeding sodium fluoride Bethke RM, Kick CH, and rock phosphate on bone Edgington BH and Wilder development in swine: a preliminary Rock phosphate N/A N/A OH 1930 report J Anim Sci: 29-33

Ritz E, Hahn K, Ketteler M, Phosphate additives in food—a Deutsches Ärzteblatt International, 109(4):49- Phosphate (unspecified) N/A N/A Kuhlmann MK and Mann J 2012 health risk 55 Phosphorus, phosphoric acid, phosphorus US Office of Health and Summary review of health effects pentoxide, phosphorus Environmental Assessment associated with elemental inorganic chlorides 48 7785-88-8 (EPA) 1990 phosphorus compounds Various EPA/600/8-89-072

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Ohio Agricultural Experiment Station Phosphoric acid and Technical Series, Bulletin No 5: various other phosphorus Phosphorus compounds in animal containing substances 48 7785-88-8 Forbes EB and Keith MH 1914 metabolism Wooster, Ohio, USA La medication phosphoree envisagee au point de vue des echanges Various Various Various Gilbert A and Posternak S 1903 nutritifs de l'organisme L'Oeuvre med-chir 36: 48

Phosphoric acid 48 7785-88-8 US EPA 2011 Phosphoric acid; CASRN 7664-38-2 Integrated Risk Information System (IRIS)

Triple super phosphate, rock phosphate, 7758-23-8, Lead and zinc bioavailability to monocalcium phosphate, 65996-95-4, Ownby DR, Galvan KA and Eisenia fetida after phosphorus tricalcium phosphate 21, 23 7758-87-4 Lydy MJ 2005 amendment to repository soils Environmental Poluution, 136: 315-321 Phosphates bicalcique et tricalcique dicalcium phosphate, 231-826-1, dans l'alimentation des animaux tricalcium phosphate 22, 23 7758-87-4 Poty P-L 1932 domestiques Ecole Nationale Veterinaire D'Alfort Dairy cattle need phosphorus in Michigan Agricultural Experiment Station ration: lack of this element causes Quarterly Bulletin, 10(4): 152-156 [ISBN Raw rock phosphate N/A N/A Reed OE and Huffman CF 1928 depraved appetites of animals 00976911] Pyrophosphoric acid, 7758-16-9, Studies in cotton seed meal sodium pyrophosphate 5, 50 2466-09-3 Withers WA and Ray BJ 1913 intoxication I: Pyrophosphoric acid Journal of Biological Chemistry, XIV(2): 53-58 Phosphoric acid and various other phosphorus Phosphoric acid, phosphates and containing substances 48 7785-88-8 Waggaman WHM 1927 phosphatic fertilisers American Chemical Society Acute oral or dermal and repeated dose 90-day oral toxicity of Seo DS, Kwon M, Jung tetrasodium pyrophosphate in Environmental Health and Toxicology. 26. tetrasodium pyrophosphate 7 7722-88-5 Sung H, Park CB 2011 Sprague Dawley (SD) rats Rat Article ID: e2011014: 9 pages Letter. Mutagenicity of octane and tetrasodium pyrophosphate in Kim SJ, Rim KT, Kim HY & bacterial reverse mutation (Ames) The Journal of Toxicological Sciences. 35(4): tetrasodium pyrophosphate 7 7722-88-5 Yang JS 2010 test bacteria 555-562 Haematological modulations in male European Rabbit, Orycytolagus cuniculus (LINN.) exposed to potassium Dhembare AJ, Gholap AB potassium dihydrogen dihydrogenorthophosphate 12 7778-77-0 & Khatode R 2011 orthophosphate rabbit J. Exp. Zool. India. 14(2): 523-526

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Phosphoric acid 48 7785-88-8 ACGIH 2001 Phosphoric acid n /a unknown Phosphate: the new cholesterol? The various inorganic role of the phosphate axis in non- various phosphates n/a n/a Ellam TJ, Chico TJA 2012 uremic vascular disease. investigations atherosclerosis, 220: 310-318 The emerging role of phosphate in inorganic phosphate' n/a n/a Giachelli CM 2009 vascular calcification n/a Kidney International (2009) 75, 890–897;

Gonzalez-Parra E, Tunon Phosphate: a stealthier killer than inorganic phosphate' n/a n/a J, Egido J & Ortiz A 2012 previously thought Cardiovascular pathology: Article in press Gutierrez OM, Anderson C, Isakova T, Scilla J, Negrea L, Anderson AH, Bellovich K, Chem J, Robinson N, Low Socioeconomic Status Ojo A, Lash J, Feldman HI Associates with Higher Serum human - cohort inorganic phosphate' n/a n/a & Wolf M 2010 Phosphate Irrespective of Race study J Am Soc Nephrol 21: 1953–1960

Hawkins DB, Demeter MJ Caustic ingestion: controversies in phosphoric acid 48 7664-38-2 & Barnett TE 1980 management. A review of 214 cases. human The laryngoscope. 90 Kendrick J, Kestenbaum B Phosphate and Cardiovascular Advances in Chronic Kidney Disease, Vol 18, inorganic phosphate' n/a n/a and Chonchol M 2011 Disease human No 2 (March), 2011: pp 113-119

Lau WL, Pai A, Loe SM & Direct Effects of Phosphate on Advances in Chronic Kidney Disease, Vol 18, inorganic phosphate' n/a n/a Giachelli CM 2011 Vascular Cell Function human No 2 (March), 2011: pp 105-112 Influences of Forest and Rangeland Ammonium phosphate, Managentent on Salmonid Fishes American Fisheries Society Special Publication diammonium phosphate 18 7722-76-1 Meehan WR 1991 and Their Habitats fish 19 Miller FP, Vandome AF, Phosphoric acid 48 7785-88-8 McBrewster J 2010 Acide phosphorique n/a Alphascript publishing - book Report: Missoula Technology and Ammonium phosphate, Ecological risk assessment: wildland Development Center, USDA Forest Service, diammonium phosphate 18 7722-76-1 Modovsky C 2007 fire-fighting chemicals enviroment Missoula, MT

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Some chemicals requiring special consideration when deciding whether to sample the particle, vapour, or Applied Occupational and Environmental Phosphoric acid 48 7785-88-8 Perez C, Soderholm SC 1991 both phases of an atmosphere n/a Hygiene, 6: 859 - 864 inorganic phosphate' - Phosphate toxicity: new insights into human and various n/a n/a Razzaque MS 2011 an old problem animals Clinical Science (2011) 120, 91–97 Interactive effects of phosphorus and Li M, Costello DM, Allen copper on Hyalella azteca via phosphorus' n/a n/a Costello G 2012 periphytonin aquatic ecosystems plankton Ecotoxicol.Environ.Saf. Intital Submission: eye irritation classification study with phosphoric Bullock C.H. & Kamienski acid in rabbits with cover letter dated NTIS OTS0545337, Stauffer Chemical phosphoric acid 48 7785-88-8 F.X. 1986 082892 Rabbit company Initial submission: toxicological NTIS OTS0545979, Stauffer Chemical investigation of phosphoric acid with company / Younger Labs. Project number Y- phosphoric acid 48 7785-88-8 Birch M.D. 1992 cover letter date 081392 Rat/rabbit 75-27 phosphorus as food supplement (source not Wise M.B., Wentworth, Availability of the phosphorus in detailed) n/a n/a R.A. & Smith, S.E. 1961 various sources for calves Cows Journal of Animal Science. 20: 329-335 Food phosphates: sodium orthophosphates, potassium orthophosphates, calcium orthophosphates, sodium pyrophosphates, potassium 2, 3, 4, 5, pyrophosphates, calcium 6, 7, 12, pyrophosphates, 13, 14, potassium 15, 21, tripolyphosphate, 22, 23, potassium polyphosphates, 24, 25, calcium sodium 26, 16, Food additives: Doctors warn of poylphosphate 17, 20, 45 Various Gruber C 2012 artificial phosphate N/A Spiegel Online

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Joint FAO/WHO expert committee on magnesium dihydrogen food additives. Seventy-sixth pyrophosphate 58 10058-44-3 FAO/WHO 2012 meeting. Geneva, 5-14 June 2012 n/a JECFA/76/SC

Associations of socioeconomic status Guitierrez OM, Katz R, and prcessed food intake with serum Peralta CA, de Boer IH, phosphorus concentration in Siscovick D, Wolf M, Roux community-living adults: The multi- AD, Kestenbaum B, ethnic study of atherosclerosis Article in press - the National Kidney phosphorus from diet n/a n/a Nettleton JA & Ix JH 2012 (MESA) human Foundation

Bell RR, Draper HH, Tzeng Physiological responses of human phosphorus from diet (form DYM, Shin HK & Schmidt adults to foods containing phosphate unspecified) n/a n/a GR 1977 additives man Journal of Nutrition. 107:42-50 1990- Principles of nutritional assessment. inorganic phosphate' n/a n/a Gibson RS 2005 2nd edition. n/a Book (no ISBN details) The tubular reabsorption of inorganic phosphate' n/a n/a Bijvoet OLM & Morgan B 1970 phosphate in man man [From Hioco - source unknown] 153-179 Effects of dietary and hormonal factors on phosphate metabolism in dietary phosphorus' n/a n/a Clark I 1970 the rat rat [From Hioco - source unknown] 89-110 inorganic orthophosphate / Orthophosphate, pyrophosphate and pyrophosphate (form not diphosphonates in calcium specifed) n/a n/a Fleisch H & Russell RGG 1970 metabolism n/a [From Hioco - source unknown] 57 - 64

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Goldsmith RS, Richards R, phosphate supplements' Dube WJ, Hulley SB, Metabolic effects and mechanism of (unspecifed) n/a n/a Holdsworth D & Ingbar SH 1970 action of phosphate supplements man [From Hioco - source unknown] 271-291 Phosphate et metabolisme phosphocalcique - regulation phosphate' normale et aspects (unspecified/various) n/a n/a Hioco DJ 1970 physiopathologiques [FRENCH] n/a Symposium summary (source unknown) phosphate' Parathyroid hormone, calcitonin and (unspecified/various) n/a n/a MacIntyre I 1970 phosphate homeostasis n/a [From Hioco - source unknown] 181-187 inorganic phosphate' The state of inorganic phosphate in (various- not specified) n/a n/a Marshall RW & Nordin BEC 1970 plasma and its relation to other ions n/a [From Hioco - source unknown] 127- 138 inorganic phosphate' Rasmussen H, Kurokawa K (various- not specified) n/a n/a & De Long A 1970 Phosphate and bone cell function n/a [From Hioco - source unknown] 7- 27 inorganic phosphate' Use of bone cultures in studying (various- not specified) n/a n/a Reynolds JJ 1970 phosphate metabolism n/a [From Hioco - source unknown] 47-55 serum phosphate (not The phosphate ion in chronic renal specified) n/a n/a Stanbury SW 1970 failure. n/a [From Hioco - source unknown] 188-208 Growth and blood chemistry of selected clariid catfishes fed Journal of Fisheries and Aquatic Science dicalcium phosphate 22 Adekunle AI 2011 phosphorus supplemented diets fish 6(5)545-554 Alonso A, Nettleton JA, Ix JH, de Boer IH, Folsom Dietary phosphorus, blood pressure, AR, Bidulescu A, and incidence of hypertension in the Kestenbaum BR, atherosclerosis risk in communities dietary phosphorus' - form Chambless LE & Jacobs study and the multi-ethnic study of unspecified n/a n/a DR 2010 atherosclerosis man Hypertension. 55:776-784 Studies of calcium and phosphorus metabolism. II. The calcium excretion of normal individuals on a low dietary phosphorus' - form Bauer W, Albright F & Aub calcium diet, also data on a case of unspecified n/a n/a JC 1930 pregnancy. various [source unknown] 75-1279 Clinical methods: the history, physical and serum phosphate (not Chapter 198. Serum inorganic laboratory examinations. 3rd edition. Ed. specified) n/a n/a Bansal VK 1990 phosphorus n/a Walker HK, Hall WD, Hurst JW

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A study of relationships between bone-related vitamins and minerals, related risk markers, and subsequent mortality in older British people: the Bates CJ, Hamer M & National Diet and Nutrition Survey of serum phosphorus n/a n/a Mishra GD 2012 People Aged 65 Years and Over man Osteoporos Int (2012) 23:457–466

Ethnic differences in dairy and related nutrient consumption among Beydoun MA, Gary TL, US adults and their association with Caballero BH, Lawrence obesity, central obesity, and the The American Journal of Clinical Nutrition. 87: serum phosphorus n/a n/a RS, Cheskin LJ & Wang Y 2008 metabolic syndrome man 1914-1925 Relation of plasma phosphate concentration to renal tubular serum phosphorus n/a n/a Bijvoet OLM 1969 reabsorption of phosphate man Clin. Sci. 37: 23-36 Le probleme calcium-phosphore de serum phosphorus n/a n/a Bock A 2012 l'insuffisance renale man Forum Med Suisse. 12(20-21) 406-409 Plasma alkaline phosphatase as a potassium criterion for determining biological dihydrogenorthophosphate 12 7778-77-0 Boyd RD, Hall D & Wu JF 1983 availability of phosphorus for swine. pig Journal of Animal Science. 57(2):396-401 ammonium phosphate Crawford JD, Osborne MM, (rat), phosphorus solutions Talbot NB, Terry ML & The parathyroid gland and (unspecifed, human) 18 7722-76-1 Morrill MF 1950 phosphorus homeostasis rat, man [source unknown] 1448-1461 Serum Phosphorus Concentrations in the Third National Health and de Boer IH, Rue TC, Nutrition Examination Survey American Journal of Kidney Diseases, Vol 53: serum phosphorus n/a n/a Kestenbaum B 2008 (NHANES III) man pp 339-407

Dhingra R, Gona P, Relations of serum phosphorus Benjamin EJ, Wang TJ, levels to echocardiographic left Aragam J, D'agostino RB, ventricular mass and incidence of European Journal of Heart Failure. 12: 812- serum phosphorus n/a n/a Kannel WB & Vasan RS 2010 heart failure in the community man 818

El-Abbadi MM, Pai AS, Phosphate feeding induces arterial Leaf EM, Yang HY, Bartley medial calcification in uremic mice: phosphate' form not BA, Quan KK, IngallsCM, role of serum phosphorus, fibroblast specified n/a n/a Liao HW & Giachelli CM 2009 growth factor-23, and osteopontin mice Kidney International. 75:1297–1307

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Elliot P, Kesteloot H, Appel Dietary Phosphorus and Blood LJ, Dyer AR, Usehima H, Pressure : International Study of dietary phosphorus (source Chan Q, Brown IJ, Zhao L Macro- and Micro-Nutrients and not specified) n/a n/a & Stamler J 2008 blood pressure man Hypertension. 51:669-675

Effect of offering dairy cows diets differing in phosphorus concentration over four successive lactations: 1. Ferris CP, Patterson DC, Food intake, milk production, tissue dicalcium phosphate 22 7757-93-9 McCoy MA & Kilpatrick DJ 2009 changes and blood metabolites cows Animal. 4(4): 545-559 orthophosphate mixture: Effect of orthophosphate on urinary monopotassium phosphate 7778-77-0, Fleisch H, Lausanne MD & pyrophosphate excretion and the and disodium phosphate 12, 3 7558-79-4 Care AD 1964 prevention of urolithiasis man The Lancet. May 16:1065-1067

Foley RN, Collins AJ, Serum Phosphorus Levels Associate serum phosphate (not Herzog CA, Ishani A & with Coronary Atherosclerosis in specified) n/a n/a Karla PA 2009 Young Adults man J Am Soc Nephrol. 20: 397-404 Soft-tissue calcification induced by tetrasodium pyrophosphate Gabbiani G, JacQmin ML & rare earth metals and its prevention (decahydrate) 7 7722-88-5 Richard RM 1966 by sodium pyrophosphate rat Br. J. Pharmac. Chemother. 27:1-9

Giachelli CM, Jono S, Shioi inorganic phosphate' (form A, Nishizawa Y, Mori K & Vascular Calcification and Inorganic American Journal of Kidney Diseases, Vol 38, not specified) n/a n/a Morii H 2001 Phosphate n/a No 4, Suppl 1 (October). pp S34-S37 phosphorus' (form not specified) n/a n/a Goldman R & Basset SH 1954 Phosphorus excretion in renal failure man [source unknown]: 1623-1628

Phosphate excretion and parathyroid disodium phosphate and Harden RM, Harrison MT & function after radioiodine therapy and monosodium phosphate 2,3 7558-80-7 Alexander WD 1963 thyroidectomy man Clin. Sci. 25: 27-36

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Harlan WR, Hull AL, Dietary phosphorus and Schomouder RL, Landis Blood pressure and nutrition in serum phosphorus (form JR, Thompson RE & Larkin adults. The national health and American Journal of Epidemiology, Vol 120(1): not specified) N/A N/A FA 1984 nutrition examination survey. Man 17-28

Harlan WR, Hull AL, High blood pressure in older Dietary phosphorus (form Schmouder RL, Landis JR, Americans. The first national health not specified) N/A N/A Larkin FA & Thompson FE 1984 and nutrition examination survey. Man Hypertension. 6:802-809

The concentration of inorganic Inorganic pyrophosphate Hausmann E, Bisaz S, pyrophosphate in human saliva and (form not specified) N/A N/A Russell RGG & Fleisch 1970 dental calculus Man Archs oral Biol. 15: 1389-1392

Effects of nitrogen, phosphorus, and Dietary phosphorus (form caffeine on calcium balance in not specified) N/A N/A Heaney RP & Recker RR 1982 women Man J Lab Clin Med. 99(1): 46-55 Associations of dietary phosphorus intake, urinary phosphate excretion, Houston J, Smith K, and fibroblast growth factor 23 with Dietary phosphorus (form Isakova T, Sowden N, Wolf vascular stiffness in chronic kidney not specified) N/A N/A M & Gutierrez OM 2012 disease Man Journal of Renal Nutrition (in press)

Serum phosphorus concentrations Ix JH, De Boer IH, Peralta and arterial stiffness among CA, Adeney KL, Duprez individuals with normal kidney Serum phosphorus (form DA, Jenny NS, Siscovick function to moderate kidney disease not specified) N/A N/A DS & Kestenbaum BR 2009 in MESA Man Clin J Am Soc Nephrol. 4:609-615

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Relationship of magnesium intake Dietary phosphorus (form Joffres MR, Reed DM & and other dietary factors to blood not specified) N/A N/A Yano K 1987 pressure: the Honolulu heart study Man Am J Clin Nutr. 45: 469-475

Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K, Morii H & Giachelli Phosphate regulation of vascular H3PO4 48 7664-38-2 CM 2000 smooth muscle cell calcification N/A Circulation Research. 87: 1-8

Long-term effects of high phosphate Phosphate (form not Jowsey J, Reiss E & intake on parathyroid hormone levels specified) N/A N/A Canterbury JM 1974 and bone metabolism Dog Acta orthop scand. 45: 801-808

An acute intake of phosphate Disodium increases parathyroid hormone hydrogenorthophosphate Karkkainen M & Lamberg- secretion and inhibits bone formation Journal of bone and mineral research. 11(12): (Na2HPO4) 3 7558-79-4 Allardt C 1996 in young women Man 1905-1912

Sodium dihydrogen phosphate Mono- and polyphosphates have (NaH2PO4.2H2O), sodium Karp HJ, Kemi VE, similar effects on calcium and tripolyphosphate Lamberg-Allardt JE & phosphorus metabolism in healthy (Na5P3O10) 2 7558-80-7 Karkkainen MUM 2012 young women Man Eur J Nutr [published online 05 July]

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High phosphorus intakes acutely and Mixture of disodium negatively affect Ca and bone phosphate and trisodium 7558-79-4 Kemi VE, Karkkainen & metabolism in a dose-dependent phosphate (P content 25%) 3, 4 7601-54-9 Lamberg-Allardt JE 2006 manner in healthy young females Man British Journal of Nutrition: 96: 545-552 The role of phosphorus in the Serum phosphorus (form development and progression of not specified) N/A N/A Kendrick J & Chonchol M 2011 vascular calcification Man Am J Kidney Dis. 58(5): 826-834

Relation of serum phosphorus levels to ankle brachial pressure index Serum phosphorus (form Kendrick J, Ix JH, Targher (from the third national health and The American Journal of Cardiology. 106: 564- not specified) N/A N/A G, Smits G & Chonchol M 2010 nutrition examination survey) Man 568

Factors which determine the concentration of calcium and of Serum phosphorus (form inorganic phosphorus in the blood not specified) N/A N/A Kramer B & Howland J 1931 serum of rats (second paper) Rat The Journal of Nutrition. 5(1): 39-60

Factors which determine the Sodium concentration of calcium and of dihydrogenorthophosphate inorganic phosphorus in the blood Johns Hopkins Hospital Bulletin. September: (NaH2PO4) 2 7558-80-7 Kramer B & Howland J 1922 serum of rats Rat 313-317 Cojoint effects of serum calcium and Larsson TE, Olauson H, phosphate on risk of total, Hagstrom E, Ingelsson E, cardiovascular, and serum phosphate (not Arnlov J, Lind L & noncardiovascular mortality in the specified) N/A N/A Sundstrom J 2010 community Man Arterioscler Thromb Vasc Biol. 30: 333-339 Effects of source of inorganic Dicalcium phosphate, phosphorus and phytase tricalcium phosphate, supplementation on performance, defluorinated rock 7757-93-9 Lee WI, Thacker PA, Han physiological parameters and bone phosphate 22,24 12167-74-7 YK 2010 mineralization in broilers Chicken J Anim Sci Biot. 1(1):15-24

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Effect of reduced dietary calcium Letourneau-Montminy MP, concentration and phytase Narcy A, Magnin M, supplementation on calcium and Sauvant D, Bernier JF, phosphorus utilization in weaning Monodicalcium phosphate 22 7757-93-9 Pomar C & Jondreville C 2010 pigs with modefied mineral status Pig J Anim Sci. 88:1706-1717 Effects of dietary phosphorus and starch levels on growth performance, body composition and nutirent Liang J-J, Liu Y-J, Tian L- utilization of grass carp Monocalcium phosphate 21 7758-23-8 X, Yang H-J & Liang G-Y 2012 (Ctenopharyngodon idella Val) Fish Aquaculture Research. 43: 1200-1208 Linefsky JP, O'Brien KD, Katz R, de Boer IH, Barasch E, Jenny NS, Association of serum phosphate Serum phosphate (form not Siscovick DS & levels with aortic valve sclerosis and Journal of the American College of Cardiology. specified) N/A N/A Kestenbaum B 2011 annular calcification Man 58(3): 291-299 Relationship between serum Lippi G, Montagnana M, phosphate and cardiovascular risk Serum phosphate (form not Salvagno GL, Targher G & factors in a large cohort of adult Diabetes Research and Clinical Practice. 84:e3- specified) N/A N/A Guidi GC 2009 outpatients Man e5

Meng J, Wassel CL, Kestenbaum BR, Collins Serum phosphorus levels and the Serum phosphate (form not TC, Criqui MH, Lewis CE, spectrum of ankle-brachial index in specified) N/A N/A Cummings SR & Ix JH 2010 older men Man Am J Epidemiol. 171: 909-916

Serum phosphate (form not Novel mechanisms in the regulation specified) N/A N/A Berndt T & Kumar R 2009 of phosphorus homeostasis Man Physiology. 24: 17-25 Phosphorus balances of adults Potassium phosphate, 7778-77-0 Moon W-H, Malzer JL & consuming several food Journal of The American Dietetic Association. dicalcium phosphate 12,22 7757-93-9 Clark HE 1974 combinations Man 64: 386-390

Unique coexpression in osteoblasts Murshed M, Harmey D, of broadly expressed genes accounts Pyrophosphate (form not Millan JL, McKee MD & for the spatial restriction of ECM specified) N/A N/A Karsenty G 2005 mineralization to bone N/A Genes & Development. 19: 1093-1104

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Nishida Y, Taketani Y, Yamanaka-Okumura H, Imamura F, Taniguchi A, Neutral sodium phosphate Sato T, Shuto E, Nashiki K, Acute effect of oral phosphate (mixture of Na2HPO4 and 7558-80-7 Arai H, Yamamoto H & loading on serum fibroblast growth NaH2PO4) 2,3 7558-79-4 Takeda E 2006 factor 23 levels in healthy men Man Kidney International. 70: 2141-2147

Phosphate (form not The effect of intravenous calcium on Clinical Science Vol 13 (Arnott WM (ed)) Shaw specified) N/A N/A Nordin BEC & Fraser R 1954 phosphate excretion Man & Sons Ltd (London)

Plasma phosphate (form Assessment of urinary phosphate not specified) N/A N/A Nordin BEC & Fraser R 1960 excretion Man The Lancet. April 30: 947-951

Phosphate (form not Biochemical aspects of parathyroid specified) N/A N/A Nordin BEC 1961 function and of hyperparathyroidism Man Advances in Clinical Chemistry. 4: 275-320

Onufrak SJ, Bellasi A, Investigation of gender heterogeneity Cardarelli F, Vaccarino V, in the associations of serum Serum phosphorus (form Muntner P, Shaw LJ and phosphorus with incident coronary American Journal of Epidemiology. 169(1): 67- not specified) N/A N/A Raggi P 2008 artery disease and all-cause mortality Man 77 Onufrak SJ, Bellasi A, Shaw LJ, Herzog CA, Phosphorus levels are associated Serum phosphorus (form Cardarelli F, Wilson PW, with subclinical atherosclerosis in the not specified) N/A N/A Vaccarino V, Raggi P 2008 general poplulation Man Atherosclerosis. 199: 424-431

Park KS, Chang JW, Kim Lower concentrations of serum TY, Kim HW, Lee EK, Kim phosphorus within the normal range H-S, Yang WS, Kim SB, could be associated with less Serum phosphorus (form Park S-K, Lee SK & Park J calcification of the coronary artery in not specified) N/A N/A S 2011 Koreans with normal renal function Man Am J Clin Nutr. 94: 1465-1470

Neutral sodium and potassium phosphate (4:1 7558-80-7 mixture of 7558-79-4 Dietary intake of phosphorus Na2HPO4/K2HPO4 and 7778-77-0 Portale AA, Halloran BP & modulates the circadian rhythm in NaH2PO4/KH2PO4) 2,3,12,13 7758-11-4 Morris RC 1987 serum concentration of phosphorus Man J Clin Invest. 80: 1147-1154

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Neutral sodium and potassium phosphate (4:1 7558-80-7 Physiologic regulation of the serum mixture of 7558-79-4 concentration of 1,25- Na2HPO4/K2HPO4 and 7778-77-0 Portale AA, Halloran BP & dihydroxyvitamin D by phosphorus in NaH2PO4/KH2PO4) 2,3,12,13 7758-11-4 Morris RC 1989 normal men Man J Clin Invest. 83: 1494-1499 Serum phosphate (form not Journal of the American College of Cardiology. specified) N/A N/A Rajamannan NM 2011 Serum phosphate concentrations Man 58(3) 299 Plasma, calcium, magnesium, phosphorus, and alkaline Plasma phosphate (form phosphatase levels in normal British not specified) N/A N/A Round JM 1973 schoolchildren Man British Medical Journal. 3: 137-140 The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone Russell RGG, Muhlbauer resorption induced by parathyroid Pyrophosphate (form not RC, Bisaz S, Williams DA hormone in tissue culture and in specified) N/A N/A and Fleisch 1970 thyroparathyroidectomised rats Rat Calc Tiss Res. 6: 183-196

The urinary excretion of inorganic Pyrophosphate (form not Russell RGG & pyrophosphate by normal subjects specified) N/A N/A Hodgkinson A 1966 and patients with renal calculus Man Clin Sci. 31: 51-62

Disodium phosphate- dihydrate Russell RGG, Edwards NA, Urinary pyrophosphate and (Na2HPO4.2H2O) 4 10028-24-7 Hodgkinson A 1964 urolithiasis Man The Lancet. 27 June: 1446

Association of serum phosphorus with left ventricular mass in men and women with stable cardiovascular Serum phosphorus (form Saab G, Whooley MA, disease: Data from the Heart and American Journal of Kidney Diseases. 56(3): not specified) N/A N/A Schiller NB, Ix JH 2010 Soul Study Man 496-505

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Inhibition by pyrophosphate and Tetrasodium Schibler D, Russel RGG & polyphosphate of aoritc calcification pyrophosphate 7 7722-88-5 Fleisch H 1968 induced by Vitamin D3 in rats Rat Clin Sci. 35: 363-372 Inhibition of skin calcification Cellular and molecular life sciences. 22(6): 367- Grahams salt 11 10361-03-2 Schibler D & Fleisch H 1966 (calciphylaxis) by polyphosphates Rat 369

Phosphorus in the blood and urine: a study of the excretion and retention Acid sodium phosphate, 7558-80-7 of phosphorus in a normal subject alkaline sodium phosphate 2 13472-35-0 Schulz I 1930 and in patients with renal disease Man Ann Int Med. 3: 667-689

Serum phosphate (form not Sim J, Smith N, Chung J, Evaluation of serum phosphorus specified) N/A N/A Kalantar-Zadeh K 2012 levels and obesity Man Kidney Res Clin Pract. 31: A16-A96 The effect of a high phosphorus Neutral sodium phosphate intake on total and ultrafiltrable (mixture of Na2HPO4 and 7558-80-7 plasma calcium and on phosphate NaH2PO4) 2,3 7558-79-4 Smith DA & Nordin BEC 1964 clearance Man Clin Sci. 26: 479-486

Potassium The relation of the dietary Ca:P ratio dihydrogenorthophosphate to serum Ca and to parathyroid (KH2PO4) 12 7778-77-0 Stoerk HC & Carnes WH 1945 volume Rat J Nutr. 29(1): 34-50 Takeda E, Yamamoto H, Phosphate (inorganic and Yamanaka-Okumura H & Dietary phosphorus in bone health organic) N/A N/A Taketani Y 2012 and quality of life Man Nutrition Reviews. 70(6): 311-321

Relation between serum phosphate Serum phosphate (form not Tonelli M, Sacks F, Pfeffer level and cardiovascular event rate in specified) N/A N/A M, Gao Z & Curhan G 2005 people with coronary disease Man Circulation. 112(17): 2627-2633

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Ion association. VI. Interactions between calcium, magnesium, Monosodium phosphate inorganic phosphate, citrate and (NaHPO4-) 2 7558-80-7 Walser M 1961 protein in normal human plasma Man J Clin Invest. 40(4): 723-730

Phosphorus-containing food Phosphorus (form not Winger RJ, Uribarri J & additives: an insidious danger for Trends in Food Science & Technology. 24: 92- stated) N/A N/A Lloyd L 2012 people with chronic kidney disease Man 102 Influences of dietary phosphorus Yan Q, Tang S, Bamikole variation on nutrient digestion, fecal Phosphorus (form not MA, Han X, Zhou C, Wang endogenous phosphorus output and specified) N/A N/A M, Sun Z, Tan Z 2011 plasma parameters of goats Goat Livestock Science. 142: 63-69 Advances in Nutritional Research, Volume 9, Phosphorus (form not The effects of high phosphorus intake chapter 11 (Preedy VR & Watson RR (Eds)): specified) N/A N/A Calvo M S 1994 on calcium homeostasis Man 183-207. New York: Raven. Present knowledge in nutrition Tenth edition, chapter 13 (Erdman JW Jr & MacDonald IA No IP substances N/A N/A Norman AW & Henry HL 2012 Vitam in D Man (Eds)): 199-213 Present knowledge in nutrition Tenth edition, chapter 14 (Erdman JW Jr & MacDonald IA No IP substances N/A N/A Traber MG 2012 Vitamin E Man (Eds)): 214 Present knowledge in nutrition Tenth edition, chapter 28 (Erdman JW Jr & MacDonald IA No IP substances N/A N/A Weaver CM 2012 Calcium Man (Eds)): 434-447 Phosphorus/phospate in Present knowledge in nutrition Tenth edition, general (form not chapter 29 (Erdman JW Jr & MacDonald IA specified), CaHPO4 21 7758-23-8 Heaney RP 2012 Phosphorus Man (Eds)): 447-458 Amaral AP, Oskouei B, Hu M-C, Moe O, Kuro-o M, Serum phosphate (form not Brand M, Hare J, Wolf M, Fibroblast growth factor 23 induces specified) N/A N/A Faul C 2012 left ventricular hypertrophy Man JACC. 59(13): E1059

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Faul C, Amaral AP, Oskouei B, Hu M-C, Sloan A, Isakova T, Gutierrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, Sutton MS, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Serum phosphate (form not Kuro-o M, Kusek JW, FGF23 induces left ventricular specified) N/A N/A Keane MG and Wolf M 2011 hypertrophy Man The Journal of Clinical Investigation. 121(11):

Gutierrez OM, Januzzi JL, Isakova T, Laliberte K, Smith K, Collerone G, Sarwar A, Hoffmann U, Coglianese E, Christenson Fibroblast growth factor-23 and left Serum phosphate (form not R, Wang TJ, deFilippi C & ventricular hypertrophy in chronic specified) N/A N/A Wolf M 2009 kidney disease Man Circulation. 119(19): 2545-2552

Serum phosphate (form not FGF-23: the rise of a novel specified) N/A N/A Heine GH, Seiler & Fliser D 2012 cardiovascular risk marker in CKD Man Nephrol Dial Transplant. 27: 3072-3081 Serum intact FGF23 associate with Mirza MAI, Larsson A, left ventricular mass, hypertrophy Serum phosphate (form not Melhus H, Lind L, Larsson and geometry in an elderly specified) N/A N/A TE 2009 population Man Atherosclerosis. 207: 546-551 Phosphorus (form not specified) N/A N/A Nordin BEC 1988 Phosphorus Man Journal of Food and Nutrition. 45(3): 62-75

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Parker BD, Schurgers LJ, The associations of fibroblast growth Brandenburg VM, factor 23 and uncarboxylated matrix Christenson RH, Vermeer Gla protein with mortality in coronary Total phosphorus (form not C, Ketteler M, Shlipak MG, artery disease: the Heart and Soul specified) N/A N/A Whooley MA & Ix JH 2010 study Man Ann Intern Med. 152: 640-648

Corrosion of high-alloy stainless Technical Research Centre of Finland, Phosphoric acid 48 7664-38-2 Varjonen O 1989 steels in the wet phosphoric acid N/A Research Reports 588. ISBN-951-38-3372-0.

Potassium dihydrogen United States Environmental Protection phosphate 12 7778-77-0 Kumar R 1998 Pesticide fact sheet N/A Agency

United States Environmental Protection Ferric orthophosphate 27 10045-86-0 Cerrelli S 1998 Pesticide fact sheet Slug & snail Agency Seiler S, Cremers B, Rebling NM, Hornof F, Jeken J, Kersting S, Steimle C, Ege P, Fehrenz The phosphatonin fibroblast growth M, Rogacev KS, Scheller B, factor 23 links calcium-phosphate Serum phosphate (form not Bohm M, Fliser D, Heine metabolism with left-ventricular specified) N/A N/A GH 2011 dysfunction and atrial fibrillation Man European Heart Journal. 32: 2688-2696 Semba R, Fink JC, Sun K, Serum fibroblast growth factor-23 Cappola AR, Dalal M, and risk of incident chronic kidney Serum phosphate (form not Crasto C, Ferrucci L & disease in older community-dwelling specified) N/A N/A Fried LP 2012 women Man Clin J Am Soc Nephrol. 7: 85-91

Plasma fibroblast growth factor 23, Plasma phosphate (form Taylor EN, Rimm EB, parathyroid hormone, phosphorus, not specified) N/A N/A Stampfer MJ, Curhan GC 2011 and risk of coronary heart disease Man American Heart Journal. 161(5): 956-961

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Udell JA, O'Donnell T, Morrow D, Jarolim P, Association of fibroblast growth No IP substances Ormland T, Sloan S, factor (FGF)-23 levels with risk of (measurement of serum Pfeffer M, Braunwald E, cardiovascular events in patients with phosphatonin (FGF-23)) N/A N/A Sabatine M 2012 stable coronary artery disease Man JACC. 59(13): E1480 The effect of dicalcium phosphate supplement in summer and winter seasons as reflected on bone blood Bakunzi F, Motsei L, phosphorus, calcium and Nyirenda M, Ndou R, magnesium levels in range breeding Dicalcium phosphate 22 7757-93-9 Dzoma B, Mwanza M 2012 beef cattle Cattle J Agric Biodivers Res. 1(4): 60-64 Effect of dietary organic acid mixture Jang HD, Yoo JS, Kim HJ, on growth performance, organ Shin SO, Hwang Y, Zhou weight, blood immunological TX, Chen YJ, Cho JH & parameter and intestinal villi Phosphoric acid 48 7664-38-2 Kim IH 2008 morphology in broilers Chicken Korean J Poult Sci. 35(1): 57-62

Tilsaetning af Fosforsyre eller Ammoniumklorid til Minkfoder i Juni Maned: Betydning for Urin pH og Danish Fur Breeders Research Center, Phosphoric acid 48 7664-38-2 Clausen TN 2000 Tilvaekst Mink Holstebro, Denmark. Annual Report: 55-57

Zhao X, Ong KJ, Ede JD, Evaluating the toxicity of Stafford JL, Ng KW, Goss hydroxyapatite nanoparticles in Hydroxyapatite 24 12167-74-7 GG & Loo SCJ 2012 Catfish cells and Zebrafish embryos Fish Wiley Online Library pH and conductivity of sodium National Technical Information Service Report Sodium phosphate 2 7558-80-7 Wright JM & VonNieda GE 1979 phosphate solutions N/A WAPD-TM-1302 Mechanisms and clinical Inorganic phosphate (form Zhu D, MacKensie NCW, consequences of vascular Frontiers in ecdocrinology [online] not specified) N/A N/A Farquharson & MacRae VE 2012 calcification Man www.frontiersin.org

Phosphate, pyrophosphate Lampropoulos CE, Osteoporosis - a risk factor for Advance online publication by Macmillan (form not specified) N/A N/A Papaioannou I & D'Cruz DP 2012 cardioivascular disease? Man Publishers Limited

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Vascular calcification in chronic Phosphate, pyrophosphate kidney disease: mechanisms and Iranian Journal of Kidney Diseases. 5(5): 285- (form not specified) N/A N/A Ossareh S 2011 clinical implications Man 299 True absorption of phosphorus from di calcium phosphate, mono Dicalcium phosphate, ammonium phosphate, triple monoammonium 7757-93-9 superphosphate and urea-phosphate phosphate, triple super 7722-76-1 in cattle by the radio phosphorus phosphate, urea-phosphate 21, 18 65996-95-4 Da Silva Filho JC 1990 dilution technique Cattle National Technical Information Service Report

Dhingra R, Sullivan LM, Relations of serum phosphorus and Fox CS, Wang TJ, calcium levels to the incidence of Serum phosphorus (form D'Agostino RB, Gaziano M cardiovascular disease in the not specified) N/A N/A & Vasan RS 2007 community Man Arch Internal Med. 167: 879-885 Serum phosphorus (form Phosphorus comes of age as a not specified) N/A N/A Anon 2007 cardiovascular risk factor Man Arch Internal Med. 167: 873-874 Incidence and progression of Kestenbaum BR, Adeney coronary calcification in chronic Serum phosphate (form not KL, Boer IH, Ix JH, Shlipak kidney disease: the multi-ethnic study specified) N/A N/A MG, Siscovick DS 2009 of atherosclerosis Man Kidney International. 76: -991-998

Kestenbaum B, Sampson JN, Rudser KD, Patterson Serum phosphate levels and Serum phosphate (form not DJ, Seliger SL, Young B, mortality risk among people with specified) N/A N/A Sherrard DJ & Andress DL 2005 chronic kidney disease Man J Am Soc Nephrol. 16: 520-528 Extracellular inorganic phosphate (form not Savica V, Bellinghieri G & Phosphorus-related mechanisms of specified) N/A N/A Santoro D 2007 vascular calcification Man Arch Intern Med. 167(21): 2368

Joint FAO/WHO expert Magnesium dihydrogen committee on food Seventy-sixth meeting Geneva 5-14 diphosphate 29 7757-86-0 additives 2012 June 2012 Man Report number JECFA/76/SC Calcium orthophosphate, Canton Castillo JG, Moguel Poultry manure and litter as phosphoric acid, rock 7758-23-8 Ordonez Y & Castellanos phosphorus sources for ruminant phosphate 21, 48 7664-38-2 Ruelas AF 1996 feedstufs Sheep Tec Pecu Mex. 34(3): 160-166

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Frisbie SH, Mitchell EJ, World Health Organization No IP substances Dustin H, Maynard DM & discontinues its drinking water Environmental Health Perspectives. 120(6): discussed N/A N/A Sarkar B 2012 guideline for manganese Man 775-778 Phosphorus, Masson et Cie, editeurs, Libraires pyrophosphate (form not del'academie de medecine, 120 Boulevard specified) N/A N/A Labbe M & Fabrykant M 1933 Le Phosphore N/A Saint-Germain, Paris Comparison and evaluation of bone Anhydrous monosodium Shastak Y, Witzig M, measurements for the assessment of phosphate, anhydrous 7558-80-7 Hartung K, Bessei W & mineral phosphorus sources in dibasic calcium phosphate 2, 22 7757-93-9 Rodehutscord M 2012 broilers Chicken Poult Sci. 9(9): 2010-2200 Monokalsiumfosfaatti ja ureafosfaatti seka kasittelematon Monocalciumphosphate, olki ja ammoniakilla kasitelty olki ureaphosphate 21 7758-23-8 Kommeri M, Rissanen H 1985 mullien ruokinnassa Cattle Tiedote - Maatalouden Tutkimuskeskus. 24: 31-40 ISSN 0359-7652 Dietary phosphate modifies lifespan Nephrology Dialysis Transplantation. 27: 3399- sodium phosphate' N/A N/A Bergwitz C 2012 in Drosophila Drosphila 3409 National Nutrition Survey: Nutrient Australian Bureau of Intakes and Physical dietary phosphate' N/A N/A Statistics 1995 Measurements, Australia, 1995 Austrailian bureau of statistics

Abramowitz M, Munter P, Coco M, Southern W, Serum Alkaline Phosphatase and Lotwin I, Hostetter TH & Phosphate and Risk of Mortality and serum phosphate' N/a N/A Melamed ML 2010 Hospitalization HUMAN Clin j Am Soc Nephrol 5: 1064-1071

No phosphates tested - Brickman AS, Coburn JW, 1,25 Dihydroxy-Vitamin D3 in Normal Vitamin D3 N/A N/A Massry SG & Norman AW 1974 Man and Patients with Renal Failure Annals of internal medicine. 80(2):161-8

The Prevalence and Nutritional Butt S, Leon JB, David CL, Implications of Fast Food Serum phosphate Chang H, Sidhu S & Sehgal Consumption Among Patients measured as an endpoint N/A N/A AR 2007 Receiving Hemodialysis humans The National Kindney Foundation, Inc

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Chen TC, Castillo L, Korycka-Dahl M & DeLuca Role of Vitamin D Metabolites in inorganic phosphate' N/A N/A HF 1974 Phosphate Transport of Rat Intestine rat Journal of Nutrition 104(8):1050-60

Serum Phosphorus and Chonchol M, Dale R, Cardiovascular Mortality in Ty·pe 2 The American Journal of Medicine. 122:380- serum phosphate' N/A N/A Schrier RW & Estacio R 2009 Diabetes human 386 phosphate' n/a n/a Fitzgerald FT 1978 Hypophosphatemia [unknown source]

Calcium-phosphate levels and cardiovascular disease in community- Foley RN, Collins AJ, dwelling adults: The Atherosclerosis phosphate' n/a n/a Ishani A & Karla PA 2008 Risk in Communities (ARIC) Study humans Am Heart J; 156:556-63

Isakova T, Guitierrez O, Postprandial Mineral Metabolism and Shah A, Castaldo L, Secondary Hyperparathyroidism in serum phosphate' N/A N/A Holmes J, Lee H & Wolf M 2008 Early CKD J Am Soc Nephrol 19: 615-623 Calcium and phosphate metabolism: An overview in health and in Kidney Stones: Medical and Surgical phosphorus' N/A N/A Lemann J 1996 calciumstone formers Management

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Matrix Extracellular Marks J, Churchill LJ, Phosphoglycoprotein Inhibits phosphate' N/A N/A Debnam ES & Unwin RJ 2008 Phosphate Transport n/a J Am Soc Nephrol 19: 2313-2320 Masuyama R, Kajita Y, Odachi J, Uehara M, Chronic phosphorus supplementation tetrapotassium Shigematsu T, Suzuki K & decreases the expression of renal triphosphate 16 n/a Goto S 2000 PTH/PTHrP receptor mRNA in rats rat Am J Nephrol. 20:491-495

Factors influencing the intake and Mataix J, Aranda P, Lopez- plasma levels of calcium, Jurando M, Sanchez C, phosphorus and magnesium in serum phosphate' n/a n/a Planells E & Llopis J 2006 southern Spain humans Eur J Nutr. 45: 349-354

Nutrition and Phosphorus - New progress and problem - . serum phosphate' n/a n/a Obi Y & Hamano T 2012 Phosphate and the risk of mortality. N/A Clin Calcium

Thatte L, Oster JR, Singer I, Bourgoigne JJ, Fishman Review of the literature: severe phosphorus' N/A n/a LM & Roos BA 1995 hyperphosphatemia human Am J Med Sci. 310(4): 167-174

phosphorus homeostasis in normal health and in chronic kidney disease patients with special emphasis on dietary phosphorus Uribarre J 2007 dietary phosphorus intake various Seminars in dialysis. 20 (4): 297-301

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Zhang Y, Post W, Dalal D, Bansal S, Blasco- Colmenares E, Jan De Serum 25-Hydroxyvitamin D, Beur S, Alonson A, Calcium, Phosphorus, and Soliman EZ, Whitsel EA, Electrocardiographic QT Interval Brugada R, Tomaselli GF & Duration: Findings from NHANES III phosphate' Guallar E 2011 and ARIC human J Clin Endocrinol Metab 96: 1873–1882, Toxicity assessments of antimony, barium, berylikium and manganese for development of ecological soil screening levels (ECO-SSL) using manganese sulphate - not Kuperman RG, Checkai enchytraeid reproduction benchmark Edgewood Chemical Biological Center - IP but read-across? RT, Phillips CT & Simini M 2002 values published online ECBC-TR-324 WATER POLLUTION STUDIES Federal Aid Project #F-243R-5 Toxicity of Manganese to Early-Life Stage and Fry of Brook Trout (Salvelinus jontinalis) and Rainbow Trout (Oncorhynchus mykiss) in manganese sulphate - not Davis PH, Brinkman S & Water Hardnesses of 30 and 150 Colorado Division of Wildlife, Fish Research IP but read-across? n/a n/a McIntyre 1998 mg/L fish Section, Fort Collins, Colorado

NTP Technical Report on the toxicology and carcinogenesis NTP TR-428. U.S. DEPARTMENT OF studies of manganese (II) sulphate HEALTH AND HUMAN SERVICES Public manganese sulphate - not monohydrate (CAS No. 10034-96-5) Health Service IP but read-across? n/a n/a NTP 1993 in F344/N rats and B6C3F1 mice rats, mice National Institutes of Health

Heine GH, Nangaku M & Calcium and phosphate impact European Heart Journal serum phosphate' n/a n/a Fliser D 2012 cardiovascular risk humans doi:10.1093/eurheartj/ehs353 Toxicity of forest fire retardant dietrich JP, Myers M, chemicals to stream-type chinook Strickland SA, Gaest AV & salmon undergoing parr-smolt Environmental Toxicology and Chemistry diammonium phosphate 18 7722-76-1 Arkoosh MR 2012 transformation fish DOI 10.1002/etc.2052

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Dietary Reference Intakes for Food and Nutrition Board calcium, phosphorus, magnesium, Institute of Medicine. ISBN: 0-309-52130-0, phosphates n/a n/a FNB 1997 vitamin D and fluoride n/a 448 pages.

Relationships between bone mineral Brot C, Jorgenson N, density, serum vitamin D metabolites Madsen OR, Jensen LB & and calcium:phosphorus intake in Journal of Internal Medicine 1999; 245: serum phosphorus' n/a n/a Sorenson OH 1999 healthy perimenopausal women human 509]516

High phosphorus intake only slightly dietary phosphate as affects serum minerals, urinary sodium Grimm M, Muller A, Hein pyridinium crosslinks and renal European Journal of Clinical Nutrition. 55: 153- dihydrogenorthophosphate 2 G, Funfstuck R & Jahreis G 2001 function in young women human 161 phosphorus '- form not Age Considerations in Nutrient Needs Journal of the American College of Nutrition, specified n/a n/a Heany RP 1996 for Bone Health: Older Adults human Vol. 15, No. 6, 575-578

The relationship between habitual dietary phosphorus and calcium intake, and bone mineral density in Ito S, Ishida H, Uenishi K, young Japanese women: a cross- dietary phosphorus' n/a n/a Murakami K & Sasaki S 2011 sectional study human Asia Pac J Clin Nutr 2011;20 (3):411-417

potassium dihydorgenorthophosphate, Anderson MP, Hunt RD, Long-Term Effect of Low Dietary calcium hydrogen Griffiths HJ, Mcintyre KW & Calcium:Phosphate Ratio on the phosphate 12 Zimmerman RE 1977 Skeleton of Cebus albifrons Monkeys monkeys J. Nutr. 107: 834-839

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Phosphoric acid as a phosphorus phosphoric acid 48 Mohamed WZ 1984 supplement for water buffaloes water buffalo MARDI Res. Bull. 12,2:266-271 Risking public health by approving some health claims? – The case of phoshorus' n/a n/a Pravst I 2011 phosphorus human Food Policy 36 (2011) 726–728

Dietary Relerence Intakes: The new basis lor recommendations Yates AA, Schlicker SA, for calcium and related nutrients, B JOURNAL OF THE AMERICAN DIETETIC phoshorus' n/a n/a Suitor CW 1998 vitamins, and choline ASSOCIATION. 98(6): 699-706 Chapuy MC, Arlot ME, DuBoeuf F, Brun J, Crouzet B, Arnaud S, Delmas P & Vitamin D3 and calcium to prevent tricalcium phosphate 23 Meunier PJ 1992 hip fractures in elderly women human N Engl J Med 1992;327:1637-42. Chevalley T, Rizzoli R, Nydegger V, Slosman D, Effects of Calcium Supplements on Rapin C-H, Michel J-P, Femoral Bone Mineral Density and Vasey H and Vertebral Fracture Rate in Vitamin-D- phosphate' n/a n/a Bonjour J-P 1994 Replete Elderly Patients HUMAN Osteoporosis Int 4:245-252

Discussion Paper on the setting of European Communities, maximum and minimum amounts for phosphorus' n/a n/a 2006 2006 vitamins and minerals in foodstuffs n/a

Hyper-phos (mixture of K Goldsmith RS, Bartos H, Phosphate Supplementation as and Na phosphates), Hyper- Hulley SB, Ingbar SH & an Adjunct in the Therapy of Multiple phos K (K phosphate) n/a n/a Moloney WC 1968 Myeloma human Arch Intern Med/Vol 122, 128-133

Low calcium:phosphorus ratio in Kemi VE, Karkkainen habitual diets affects serum MUM, Rita HJ, Laaksonen parathyroid hormone concentration MML, Outila TA & Lamberg- and calcium metabolism in healthy British Journal of Nutrition (2010), 103, dietary P' n/a n/a Allardt CJE 2010 women with adequate calcium intake human 561–568

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Habitual high phosphorus intakes Kemi VE, Karkkainen and foods with phosphate additives MUM, Rita HJ, Viljakainin negatively affect serum parathyroid HT, Laaksonen MML, hormone concentration: a cross- Outila TA & Lamberg- sectional study on healthy dietary P' n/a n/a Allardt CJE 2009 premenopausal women human Public Health Nutrition: 12(10), 1885–1892

Effects of dietary factors on skeletal integrity in adults: calcium, dietary P' n/a n/a Chinn. HI. LSRO Report 1983 phosphorus, vitamin D and protei LSRO Report The Effect of Differing Dietary Pettifor JM, Marie PJ, Sly Calcium and Phosphorus Contents MR, de Bruyn D, Ross F, on Mineral Metabolism and Bone Isdale JM, de Klerk WA & Histomorphometry in Young Vitamin dietary P' n/a n/a Van Der Walt WH 1984 D-Replete Baboons monkeys Calcif Tissue Int (1984) 36:668-676

Persistently elevated parathyroid hormone secretion and action in Calvo M S, Kumar R & young after four weeks of ingesting Journal of Clinical Endocrinology and dietary phosphate n/a n/a Heath H 1990 high phosphorus, low calcium diets human Metabolism. 70 (5):

Optimal nutrition: calcium, Proceedings of the Nutrition Society, 58, pp serum phosphate n/a n/a Cashman KD & Flynn A 1999 magnesium and phosphorus. various 477487 Circadian variation in ionized calcium Calvo MS, Eastell R, Offord and intact parathyroid hormone: KP, Bergstrahl EJ & Burrit evidence for sex differences in Journal of Clinical Endocrinology and serum phosphate n/a n/a MF 1991 calcium homeostasis human Metabolism. 72(1) 69-76 Elevated secretion and action of serum parathyroid hormone in young adults consuming high phosphorus, Calvo MS, Kumar K & low calcium diets assembled from Journal of Clinical Endocrinology and dietary phosphorus n/a n/a Heath H 1988 common foods human Metabolism. 66(4): 823-829

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Orthophosphate Therapy Decreases Urinary Calcium Excretion and Van Der Berg CJ, Kumar Serum 1,25 Dihydroxyvitamin D R, Wilson DM, Heath H & Concentrations in Idiopathic Journal of Clinical Endocrinology and serum phosphate n/a n/a Smith LH 1980 Hypercalciuria human Metabolism. 51(5): 998 - 1001 Relative bioavailability of different phosphorus supplements in broiler phosphorus n/a n/a Rao SVR & Reddy VR 2001 and layer chicken diets chicken J. Anim. Sci. 2001. Vol. 14, No.7: 979-985 Phosphorus and its compounds. Vol [handbook] Interscience publishers. ISBN various n/a n/a Van Wazer 1958 1: Chemistry n/a unknown Phosphorus and its compounds. Vol 2: Technology, biological functions [handbook] Interscience publishers. ISBN various n/a n/a Van Wazer 1958 and applications n/a unknown

Effect of a Bone Graft Substitute Qiu T, Wang Y, Han Y, βTricalcium Phosphate on Journal of Wuhan University of Technology- β-tricalcium phosphate 23 7758-87-4 Jiang X & Li S 2012 Osteoblastic Genes mRNA Exprssion Mater. Sci. Ed. 911 - 915

Evaluation of Meat and Bone Meal and Mono-Sodium Phosphate as Supplemental Dietary Phosphorus Sources for Broodstock Nile Tilapia Monosodium phosphate Mabroke RS, Tahoun AM, (Oreochromis niloticus) Under the Turkish Journal of Fisheries and Aquatic (NaHPO4-) 2 7758-80-7 Suloma A & El-Haroun ER 2013 Conditions of Hapa-in- Pond System fish Sciences 13: 11-18 Inorganic Phosphate as a Novel Spina A, Sapio L, Esposito Signaling Molecule with Monosodium phosphate A, Di Mailolo F, Sorvillo L & Antiproliferative Action in MDA-MB BioResearch Open Access Volume 0, Number (NaHPO4-) 2 7758-80-7 Naviglio S 2012 231 Breast Cancer Cells N/A 0, Month 2012 Availability to ponies of calcium and dicalcium phosphate and 7757-93-9, phosphorus from various monosodium phosphate 22, 2 7758-80-7 Hintz HF & Schryver HF 1972 supplements ponies Journal of Animal Science. Vol 34 (6) 979-980 Effects of two levels of phosphorus Brintrup R, Mooren T, intake on performance and Meyer U, Spiekers H & faecal phosphorus excretion of dairy J. Anim. Physiol. a. Anim. Nutr. 69 (1993), 29- monocalcium phosphate 21 7758-23-8 Pfeffer E 1993 cows cows 36 Calcium and Phosphorus Kincaid RL Hillers JK & Supplementation of Rations for sodium tripolyphosphate 0 7758-29-4 Cronrath JD 1981 Lactating Cows cows J Dairy Sci 64:754-758

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Dietary phosphate - from Dairy Products and Prostate Cancer dairy products n/a various Newmark HL, Heany RP 2010 Risk humans Nutrition and Cancer, 62(3), 297–299 Call JW, Butcher JE, Clinical Effects of low dietary Shupe JL, Lamb RC, phosphorus concentrations in feed Monosodium phosphate 2 7758-80-7 Boman RL & Olson AE 1987 given to lactating dairy cows cows Am J Vet Res, 48(1): 133-136 Ovarian Activity and Reproductive Tallam SK, Ealy AD, Bryan Performance of Dairy Cows Fed Dietary phosphate n/a ? KD & Wu Z 2005 Different Amounts of Phosphorus cows J. Dairy Sci. 88:3609-3618

Effect of Three Calcium: Phosphorus Ratios on Performance of Growing Dietary phosphate n/a ? Ricketts RE, Campbell JR 1970 Holstein Steers cows J. Dairy Sci. 53(7): 898 -903 Smith AM, Holck GL & 1. Calcium, Phosphorus and Vitamin Dietary phosphate n/a ? Spafford HB 1966 D cows J. Dairy Sci. 49: 239-243 Influence of Long-Term Feeding of Limited Amounts of Phosphorus on Dry Matter Intake, Milk Production, and Body Weaght of Monosodium phosphate 2 7758-80-7 Valk H & Sebek LBJ 1999 Dairy Cows cows J Dairy Sci 82:2157-2163 Effects of Varying Amounts of Steevens BJ, Bush LJ, Calcium and Phosphorus in Monosodium phosphate 2 7758-80-7 Stout JD & Williams EI 1971 Rations for Dairy Cows cows J Dairy Sci 54(5): 655-661 Estrous Behavior and Endocrine Hurley WL, Edgerton LA, Status of Dairy Heifers with Varied Monosodium phosphate 2 7758-80-7 Olds D & Hemekn RW 1982 Intakes of Phosphorus cows J Dairy Sci 65:1979-1986

Effect of dietary phosphorus Lopez H, Wu Z, Satter LD concentration on estrous behavior of Monosodium phosphate 2 7758-80-7 & Wiltbank MC 2004 lactating dairy cows cows Theriogeoology 61 (2004) 437-445

Long-term effects of feeding diets Odongo NE, McKnight D, without mineral phosphorus KoekKoek A, Fisher JW, supplementation on the performance Sharpe P, Kebreab E, and phosphorus excretion in high- Canadian Journal of Animal Science 87(4): dicalcium phosphate 22 7757-93-9 France J & McBride BW 2007 yielding dairy cows cows 639-646

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Influence of Phosphorus Intake on Excretion and Blood Plasma and Valk H, Sebek LBJ & Saliva Concentrations of Phosphorus dietary P Beynen AC 2002 in Dairy Cows cows J. Dairy Sci. 85:2642-2649 Brodison JA, Goodall EA, Influence of dietary phosphorus on Armstrong JD, Given DI , the performance of lactating dairy Gordon FJ, McCaughey cattle Dietary P WJ & Todd JR 1989 cows J. agric. Sci., Camb. (1989), 112, 303-311. WHO FOOD ADDITIVES SERIES: 67: Safety evaluation of prepared by the Seventy-sixth meeting of the Magnesium dihydrogen certain food additives Joint FAO/WHO Expert Committee on Food diphosphate 57/58 20768-12-1 JEFCA 2012 n/a Additives (JECFA) World Health

Yamamoto KT, Robinson- Cohen C, de Oliveira MC, Kostina A, Nettleton JA, Ix JH, Nguyen H, Eng J, Lima dietary phosphorus JAC, Siscovick DS, Weiss Dietary phosphorus is associated International Society of Nephrology (unknown) n/a n/a NS & Kestenbaum B 2012 with greater left ventricular mass human (http://www.kidney-international.org) dicalcium phosphate, Brown WR, Krook L & Atrophic rhinitis in swine. Etiology, potassium diphosphate 22 7757-93-9 Pond WG 1966 pathogenesis and prophylaxis Cornell Veterinarian 56(1) 3-108 tricopper Laha D, Bhattacharya D, Evaluation of copper iodide and bis(orthophosphate) Pramanik A, Santra CR, copper phosphate nanoparticles for [NANO] 36 7798-23-4 Pramanik P & Karmakar P 2012 their potential cytotoxic effect cells Toxicol. Res., 2012, 1, 131 β-tricalcium phosphate unknown (in Japanese) Ames test (title unknown in [NANO] 23 7758-87-4 Chen? 2005 Japanese) bacteria J Clin Stomat ol ,Dec, 2005, Vol. 21, No. 12 Effects of Neutral Phytase Supplementation on Biochemical Parameters in Grass Carp, Ctenopharyngodon idellus, and Gibel Carp, Carassius auratus gibelio, Fed Liu L, Luo Y, Liang XF, Different Levels of Journal of the world aquaculture society. 44(1): monocalcium phosphate 21 7758-23-8 Wang W & Wu J 2013 Monocalcium Phosphate fish 56 The Absorption of Tricalcium Phosphate and its Acute Metabolic tricalcium phosphate 23 7758-87-4 Shires R & Kessler GM 1990 Effects humans Calcif Tissue Int (1990) 47:142-144

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Postprandial effects of calcium phosphate supplementation on plasma concentration-double-blind, pentacalcium hydroxy- Trautvetter U, Kiehntopf M placebo-controlled cross-over human triphosphate 24 12167-74-7 & Jahreis G 2013 study humans Nutrition Journal 2013, 12:30 The Acute Metabolic Effects of Oral Tricalcium Phosphate and tricalcium phosphate 23 7758-87-4 Yang RS, Liu TK & Tsai KS 1994 Calcium Carbonate humans Calcif Tissue Int (1994) 55:335-341 0, 2, 3, 4, 5, 7,14,15, Emergency do not consume/do not 50, 16, Willhite CC, Ball GL & Bhat use concentrations for blended Human and Experimental Toxicology 32(3) various 10, 8, various VS 2013 phosphates in drinking water various 241–259 Oral Sodium Phosphate Solution A Review of its Use as a Colorectal sodium phosphate' ? ? Curran MP & Plosker GL 2004 Cleanser human Drugs 2004; 64 (15): 1697-1714 Age as a predictor of Gumurdulu Y, Serin E, hyperphosphatemia after oral Ozer B, Gokcel A & phosphosoda administration for Journal of Gastroenterology and Heptology. oral sodium phosphate' ? ? Boyacioglu S 2004 colon preparation human 19: 68-72

The Effect of Oral Sodium Phosphate Kurana A, McLean L, Drug Products on Renal Function in oral sodium phosphate' ? ? Atkinson S & Foulks CJ 2008 Adults Undergoing Bowel Endoscopy human Arch Intem Med. 2008;168(6):593-597 A Prospective Assessment of Renal Impairment After Preparation Korsten MA, Spungen AM, for Colonoscopy: Oral Sodium Rosman AR, Ancha HR, Phosphate Appears to Be Safe Post JB, Shaw S, Hunt KK, in Well-Hydrated Subjects with oral sodium phosphate' ? ? Williams R & Bauman WA 2010 Normal Renal Status human Dig Dis Sci (2010) 55:2021–2029 Acute Hyperphosphatemia Caused by Sodium Phosphate Enema in a Nir-Paz R, Choen R & Patient with Liver Dysfunction and oral sodium phosphate' ? ? Haviv YS 1999 Chronic Renal Failure human Renal Failure, 21(5), 541-544

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Extreme hyperphosphatemia and Orias M, Mahnensmith RL, acute renal failure after a phospohrus- oral sodium phosphate' ? ? Perazella MA 1999 containing bowel regimen human American Journal of Nephrology. 19: 60-63 Fatal hypocalcemic, hyperphosphatemic, metabolic acidosis following sequential Pitcher DE, Ford RS, sodium phosphate-based enema oral sodium phosphate' ? ? Nelson MT & Dickenson E 1997 administration human Gastrointestinal endoscopy. 46(3) Gonlusen G, Akgun H, Renal Failure and Nephrocalcinosis Ertan A, Olivero J & Truong Associated With Oral Sodium oral sodium phosphate' ? ? LD 2006 Phosphate Bowel Cleansing human Arch Pathol Lab Med. 2006;130:101-106)

Ahmed M, Raval P and Oral sodium phosphate catharsis and the American Journal of Gastroenterology. oral sodium phosphate' ? ? Bunganza G 1996 acute renal failure human 91(6): 1261-1262 sodium phosphate Fatal acute sodium phosphate Acta gastroenterol. belg., 2005, 68, preparation -MSP and DSP 2, 3 7758-80-7 Farah R 2005 enemas intoxication human 392-393 disodium phosphate, sodium pyrophospate (TSPP?), sodium Some effects of different phosphate tripolyphosphate, sodium 3, 5/7, 0, Mahoney AW & Hendricks compounds on iron and calcium JOURNAL OF FOOD SCIENCE- Vol. 43, No. metaphosphate 10 various DG 1978 absorption rats 5: 1471-1476 Fatal Hypocalcemia From Phosphate Absorption From Laxative oral sodium phosphate' ? ? McConnell TH 1971 Preparation human JAMA, April 5, 1971 • Vol 216, No 1

Kinetics of phosphate absorption in monosodium phosphate, lactating dairy cows after enteral calcium hydrogen 7757-93-9, Grunberg W, Dobbelaar P administration of sodium phosphate phosphate 2, 22 7758-80-7 & Breves G 2013 or calcium phosphate salts cows British Journal of Nutrition (2013) 1-12 Tavares DS, Castro LO, Synthesis and cytotoxicity evaluation Soares GDA, Alves GG & of granular magnesium substituted β- β-tricalcium phosphate 23 7758-87-4 Granjeiro JM 2013 tricalcium phosphate n/a J Appl Oral Sci. 21(1): 37-42

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

The effects of elevated concentrations of dissolved inorganic phosphate in seawater on the growth potassium dihydrogen and survival of juvenile abalone, phosphate 12 James PJ & Barr NG 2012 Haliotis iris abalone Aquaculture Research, 2012, 43, 438–446

Water-soluble Phosphates: Observed Effects on Embryonic potassium dihydrogen Toor HS, Sehgal HS & Brar Development, Hatching Time, and phosphate 12 CS 1983 Survival of Common Carp fish Prog. Fish-Cult. 45(2): 134-135

The effect of high ortho-phosphate water levels on growth, feed intake, nutrient utilization and health status Van Bussel CGJ, ofjuvenile turbot (Psetta maxima) disodium hydrogen Mahlmann L, Kroeckel S, reared in intensive recirculating phsphate 3 Schroeder JP & Schulz C 2013 aquaculture systems (RAS) fish Aquacultural Engineering Structural characterisation of silicon silicon orthophosphate 64 12037-47-7 Poojary DM 1993 orthophosphate n/a Inorg. Chim. Acta. 208: 23-29 Enviro Technical Information for Publications Section, Environmental Protection phosphoric acid 48 7446-38-2 Environment Canada 1985 Problem Spills: Phosphoric acid Various Service, Environment Canada Phosphoric acid storage and phosphoric acid 48 7446-38-2 Barber J.C 1974 containment at Fertilizer Plants n/a Journal unknwon

Procedures for the destruction of the foliage of peas, field beans, [Frühjahrsrübs] and spring oilseed rape and weeds by Takala, Mauri LLMarie, Phosphoric ??? before combine phosphoric acid 48 7446-38-2 Palkane, Myttaala 1978 harvesting [translated from German] n/a Source unknown

The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant European Journal of Pharmacology - Article in Dietary phosphate n/a n/a Chen TH et al 2012 mice mice press FNCE hot topic: Is phosphorus the Food Navigator USA.COM - Pub 15 October Dietary phosphate n/a n/a Watson E 2012 new trans fat? N/A 2012

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Effect of calcium supplements on risk of myocardial infarction and Serum phosphate n/a n/a Bolland MJ et al 2010 cardiovascular events: meta-analysis N/A BMJ 2010;341:c3691

Serum phosphate levels and the risk of cardiovascular disease and metabolic syndrome: A double-edged Diabetes Research and Clinical Practice. Serum phosphate n/a n/a Park W et al 2008 sword N/A 84:119-125

Serum calcium, phosphorus and cardiovascular events in post- International Journal of Cardiology 149 (2011) Serum phosphate n/a n/a Slinin Y et al 2011 menopausal women N/A 335–340

Striker GE, Grosjean F and Phosphate and CVD : It's All in Arterioscler Thromb Vasc Biol. 2011;31:1951- Serum phosphate n/a n/a Vlassara H 2011 What's on the Table n/a 1952 Inorganic Phosphate Accelerates the Migration of Vascular Smooth Muscle Cells: Evidence for the Involvement Serum phosphate n/a n/a Rangrez AY et al 2012 of miR-223 N/A PLOS ONE. Vol 7. Issue 10

Walsh JP, Divitini ML and Serum phosphate n/a n/a Knuiman MW 2012 Calcium and cardiovascular disease N/A Journal unknown [In Polish] 'Phosphate fertiliser Roczniki Aktukmii Rol ńicztj w Pomaniu- Serum phosphate n/a n/a Ponikiewska T et al 1980 effects on field cows cows CXIX(1980) Some studies on the formation in vivo of pyridoxal phosphate in rats Serum phosphate n/a n/a Chatterjee AJ and Datta SD 1972 receiving high-fat diet rats The Journal of vitaminology. 18:189-193 Chapter 4: Nutrition and Serum phosphate n/a n/a Draper HH and Bell RR 1979 Osteoporosis N/A Book chapter - source unknown

Serum phosphate n/a n/a Shroff R 2012 Phosphate is a vascular toxin N/A Pediatric Nephrology

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[IN GERMAN] Effects of free phosphoric acid as a supplement to Complete feed FTIR piglets and pigs Roth Von FX, Kreuzer M on the balance sheets some minerals J. Animal. Physiol. And Anim. Nurtr. 59: 247- dicaclium phosphate 22 7757-93-9 and Kirchgessner 1988 (P, Ca, K, Na, Mg, Zn) ( translated) pigs 254

The effects produced by an increase in the calcium and phosphorus content of the diet on the calcuim mixture of mon- and Haldi J, Bachmnn G, Wynn and phosphorus balance and on dibasic sodium phosphate 2,3 n/a W and Ensor C 1939 various bodily constiuents of the rat rats The Journal of Nutrition 1939 Experimental Studies on Serum phosphate n/a n/a KrooK L et al 1975 Osteoporosis N/A Meth. Achiev. exp. Pathol., vol. 7, pp. 72-108

Serum phosphate and hip bone mineral density as additional factors for high vascular calcification scores in a community-dwelling: The São Serum phosphate n/a n/a Figueiredo CP et al 2013 Paulo Ageing & Health Study (SPAH) N/A Bone 52 (2013) 354–359 A problem for ESRD patieents and Serum phosphate n/a n/a Harum P 2012 the public N/A Nephrology News & Issues • July 2012

Phosphorus Additives in Food and Serum phosphate n/a n/a Uribarre J 2009 their Effect in Dialysis Patients N/A CJASN August 2009 vol. 4 no. 8 1290-1292

Eddington H, Sinhal D and Vascular calcification in chronic Serum phosphate n/a n/a Kalra PA 2009 kidney disease: A clinical review N/A Journal of Renal Care. 35(1):45-50 Calcium, Phosphorus, Parathyroid Hormone, and Cardiovascular Disease in Hemodialysis Patients: Slniin Y, Foley R and The USRDS Waves 1, 3, and 4 Serum phosphate n/a n/a Collins AJ 2005 Study N/A J Am Soc Nephrol 16: 1788–1793

Serum phosphate and mortality in Serum phosphate n/a n/a Eddington H et al 2010 patients with chronic kidney disease N/A Clin J Am Soc Nephrol 5: 2251–2257

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Longitudinal Relationships among Coronary Artery Calcification, Serum CJASN ePress. Published on November 5, Serum phosphate n/a n/a Tuttle KR and Short RA 2009 Phosphorus, and Kidney Function N/A 2009 Hidden Sources of Phosphorus in the Typical American Diet: Does it Matter Serum phosphate n/a n/a Urribarre J and Calvo M 2003 in Nephrology? N/A Journal unknown

Effects of phosphate binders in Serum phosphate n/a n/a Block GA et al 2012 moderate CKD N/A J Am Soc Nephrol 23: 1407–1415, Phosphate Binders: New Study Raises Questions about Safety and Serum phosphate n/a n/a Weaver J 2012 Effi cacy N/A Nephrology times. 5(8):16-17 Calcium orthophosphates. Applications in Nature, Biology and ISBN 978-981-4316-62-0 (Hardcover) calcium orthophosphates 21 various Dorozhkin S 2012 Medicine N/A ISBN 978-981-4364-17-1 (eBook) calcium orthophosphates 21 various Dorozhkin S 2007 Calcium orthophosphates N/A J Mater Sci (2007) 42:1061–1095 Review Calcium Orthophosphates in Nature, calcium orthophosphates 21 various Dorozhkin S 2009 Biology and Medicine N/A Materials 2009, 2, 399-498; calcium Kim E, Yoo S, Ro HY, Han Environmental Health and Toxicology. 28. 1-7 hydrogenorthophosphate, HJ, Baek YW, Eom IC, Kim Aquatic Toxicity Assessment of Fish, daphnia, Copyright © 2013 The Korean Society of tricalcium phosphate 22,24 7757-93-9 HM, Kim P & Choi K 2013 Phosphate Compounds algae Environmental Health and Toxicology mixture: tetracalcium phosphate, α-tricalcium In vitro genotoxicity of calcium phosphate, sodium Altay MA, Erturk C, phosphate-based bone substitute glycerophosphate and Kocyigit A, Taskin A & material on human peripheral polydimethylsiloxane N/A N/A Celik H 2013 mononuclear leukocytes N/A Acta Medica Mediterranea. 29:723-729 Phosphate supplementation, Bredle DL, Stager JM, cardiovascular function, and exercise Journal of Applied Physiology. 64 (4): 1821- dicalcium phosphate 22 7757-93-9 Brechue WF & Farber MO 1988 performance in humans N/A 1826 De Los Angeles Aguilar M, α-tricalcium phosphate Pina MC, Lopex RM, Cytotoxic and genotoxic effects of the (90%), hydroxyapatite, Rodriguez L & Driessens exposure of human lymphocytes to a Journal of Applied Biomaterials & calcium carbonate N/A N/A FCM 2005 calcium phosphate cement in vitro N/A Biomechanics 2005; Vol. 3 no. 1: 29-34

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sodium phosphate loading improves Folland P, Stern R, Brickley laboratory cycling time trial Journal of Science and Medicine in Sport trisodium phosphate 4 G 2008 performance in trained cyclists human (2008) 11, 464-468 Galloway SDR, Tremblay The effects of acute phosphate MS, Sexsmith JR & supplementation in subjects of dicalcium phosphate 22 7757-93-9 Roberts CJ 1995 different aerobic fitness levels human Eur J Appl Physiol (1996) 72:224-230 Gergulova R, Tepavitcharova S, Rabadijiva D, Sexanova K, Biomimetric Synthesis of Modified ion modified calcium Ilieva R, Alexandrova R & Calcium Phosphate Fine powders N/A N/A Abdonova-Lilova B 2013 Powders and Their in Vitro Studies CELLS [UNKNOWN]

Kreider RB, Miler GW, Effects of phosphate loading on Williams MH, Somma CT, oxygen uptake, ventilatory anaerobic Medicine and Science in Sports and Exercise. trisodium phosphate 4 Nasser TA 1990 threshold and run performance humans 22(2): 250-256

Layton JB, Klemmer PJ Sodium Phosphate Does Not Christiansen CF, Bomback Increase Risk For Acute Kidney AS, Baron JA, Sandler RS, Injury After Routine Colonoscopy, Clinical Gastroenterology and Hepatology. oral sodium phosphate Ksirsagar AV 2014 Compared With Polyethylene Glycol Accepted manusript. Oxygen delivery and cardiac output Mannix ET, Stager JM, during exercise following oral Medicine and Science in Sports and Exercise. dicalcium phosphate 22 Harris A & Farber MO 1990 phosphate-glucose humans 22(3): 341-347 Morishita K, Shirai A, Kubota M, Katakuru Y, The Progression of Aging in Klotho Nabeshima Y, Takeshige K Mutant Mice Can Be Modified by monopotassium phosphate 13 & Kamiya T 2001 Dietary Phosphorus and Zinc mice The Journal of Nutrition. 131:3182-3188

Reginster, Denis D, Bartsch Acute biochemical variations induced V, Deroisy R, Zegels B & by four different calcium salts in tricalcium phosphate 24 Franchimont P 1993 healthy male volunteers humans Osteoporosis International. 3: 271-275 Role of Hyperphosphatemia and 1,25- Dihydroxyvitamin D in Vascular Stubbs JR, Liu S, Tang W , Calcification and Mortality in Zhou J, Wang Y, Yao X, & Fibroblastic Growth Factor 23 Null serum phosphate N/A N/A Quarles LD 2007 Mice mice J Am Soc Nephrol 18: 2116–2124,

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Biological Acute Toxicity: Determining the Effects of TFT-LCD Pollutants on Daphnia N/A N/A N/A Wu M 2013 magna in Aquatic Systems Daphnia UNKNOWN magnesium phosphate Zhang B, Yu Y, Changsen Ames test on magnesium phosphate cement N/A N/A L 2009 cement bacteria Gu yu guanjie sunshang zazhi. 10 Lansiedel R, Ma-Hock L, Hofmanm T, Wiemann M, Strauss V, Treumann S, Wohlleben W, Groters S, Application of short-term inhalation silicon orthophosphate - WienchK & Van studies to assess the inhalation nanoparticle 64 12037-47-7 Ravenzwaay B 2014 toxicity of nanomaterials Particle and Fibre Toxicology. 11:!6 Fetuin-A and Albumin Alter Cytotoxic Effects of Calcium Dautova Y, Kozlova D, Phosphate Nanoparticles on Human CaP nanoparticles - likely Skepper JN, Epple M, Vascular Smooth PLOS One 9(5): e97565 hydroyapatite 24 1306-06-5 Bootman MD, Proudfoot D 2014 Muscle Cells cells doi:10.1371/journal.pone.0097565

G.D. Webler, M.J.M. Characterization and evaluation of Zapata, L.C. Agra, E. cytotoxicity of biphasic calcium Barreto, A.O.S. Silva, J.M. phosphate synthesized by a solid Current Applied Physics. DOI: HAP/ β-TCP mix (various ratios) 24/23 1306-06-5 Hickmann, E.J.S. Fonseca 2014 state reaction route cells 10.1016/j.cap.2014.03.026 DOUBLE-BLIND, VEHICLE- CONTROLLED RANDOMIZED TWELVE-MONTH J. POIRIER, H. SEMPLE,J. NEURODEVELOPMENTAL DAVIES, R. LAPOINTE, TOXICITY STUDY OF M. DZIWENKA, M. HILTZ COMMON ALUMINUM SALTS IN Aluminium citrate N/A N/A AND D. MUJIBI 2011 THE RAT rat Neuroscience 193: 338–362

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