VPS26A Polyclonal Antibody Gene Alias: FLJ12930, HB58, Hbeta58, PEP8A, VPS26

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VPS26A polyclonal antibody Gene Alias: FLJ12930, HB58, Hbeta58, PEP8A, VPS26 Gene Summary: This gene belongs to a group of Catalog Number: PAB6573 vacuolar protein sorting (VPS) genes. The encoded Regulatory Status: For research use only (RUO) protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde Product Description: Goat polyclonal antibody raised transport of proteins from endosomes to the trans-Golgi against synthetic peptide of VPS26A. network. The close structural similarity between the yeast and human proteins that make up this complex Immunogen: A synthetic peptide corresponding to suggests a similarity in function. Expression studies in human VPS26A. yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core Sequence: C-SPESQASAEQPEM of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. Host: Goat [provided by RefSeq] Theoretical MW (kDa): 38.2 References: 1. Human orthologs of yeast vacuolar protein sorting Reactivity: Human proteins Vps26, 29, and 35: assembly into multimeric Applications: ELISA, WB-Ti, WB-Tr complexes. Haft CR, de la Luz Sierra M, Bafford R, (See our web site product page for detailed applications Lesniak MA, Barr VA, Taylor SI. Mol Biol Cell. 2000 information) Dec;11(12):4105-16. Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols Specificity: This antibody is expected tp recognize isoform 1 (NP_004887.2) only. Form: Liquid Purification: Antigen affinity purification Concentration: 0.5 mg/mL Recommend Usage: ELISA (1:4000) Western Blot (1-2 ug/mL) The optimal working dilution should be determined by the end user. Storage Buffer: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide) Storage Instruction: Store at -20°C. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 9559 Gene Symbol: VPS26A Page 1/1 Powered by TCPDF (www.tcpdf.org).

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Atypical Parkinsonism–Associated Retromer Mutant Alters Endosomal Sorting of Specific Cargo Proteins
JCB: Report Atypical parkinsonism–associated retromer mutant alters endosomal sorting of specific cargo proteins Kirsty J. McMillan,1 Matthew Gallon,1* Adam P. Jellett,1* Thomas Clairfeuille,3 Frances C. Tilley,1 Ian McGough,1 Chris M. Danson,1 Kate J. Heesom,2 Kevin A. Wilkinson,1 Brett M. Collins,3 and Peter J. Cullen1 1School of Biochemistry and 2Proteomics Facility, School of Biochemistry, University of Bristol, Bristol BS8 1TD, England, UK 3Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia The retromer complex acts as a scaffold for endosomal protein complexes that sort integral membrane proteins to vari- ous cellular destinations. The retromer complex is a heterotrimer of VPS29, VPS35, and VPS26. Two of these paral- ogues, VPS26A and VPS26B, are expressed in humans. Retromer dysfunction is associated with neurodegenerative disease, and recently, three VPS26A mutations (p.K93E, p.M112V, and p.K297X) were discovered to be associated with atypical parkinsonism. Here, we apply quantitative proteomics to provide a detailed description of the retromer interac- tome. By establishing a comparative proteomic methodology, we identify how this interactome is perturbed in atypical parkinsonism-associated VPS26A mutants. In particular, we describe a selective defect in the association of VPS26A (p.K297X) with the SNX27 cargo adaptor. By showing how a retromer mutant leads to altered endosomal sorting of specific PDZ ligand–containing cargo proteins, we reveal a new mechanism for perturbed endosomal cargo sorting in atypical parkinsonism. Introduction Retromer is a highly conserved heterotrimer of VPS29, homologue (WASH) complex (McGough et al., 2014a; Za- VPS35, and VPS26.
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VPS26A Rabbit Pab
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Dr. Alan M. Jones 1 Address
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