Gazefinder As a Clinical Supplementary Tool For
Fujioka et al. Molecular Autism (2016) 7:19 DOI 10.1186/s13229-016-0083-y RESEARCH Open Access Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults Toru Fujioka1,2,3, Keisuke Inohara1,4, Yuko Okamoto2,3, Yasuhiro Masuya1, Makoto Ishitobi1,5, Daisuke N. Saito2,3,6, Minyoung Jung2,3, Sumiyoshi Arai2,3, Yukiko Matsumura1, Takashi X. Fujisawa2,3, Kosuke Narita7, Katsuaki Suzuki3,8,9, Kenji J. Tsuchiya3,8,9, Norio Mori3,8,9, Taiichi Katayama3, Makoto Sato2,3,10,11, Toshio Munesue3,12, Hidehiko Okazawa2,3,6, Akemi Tomoda2,3, Yuji Wada1,2,3 and Hirotaka Kosaka1,2,3* Abstract Background: Gaze abnormality is a diagnostic criterion for autism spectrum disorder (ASD). However, few easy-to-use clinical tools exist to evaluate the unique eye-gaze patterns of ASD. Recently, we developed Gazefinder, an all-in-one eye-tracking system for early detection of ASD in toddlers. Because abnormal gaze patterns have been documented in various ASD age groups, we predicted that Gazefinder might also detect gaze abnormality in adolescents and adults. In this study, we tested whether Gazefinder could identify unique gaze patterns in adolescents and adults with ASD. Methods: We measured the percentage of eye fixation time allocated to particular objects depicted in movies (i.e., eyes and mouth in human face movies, upright and inverted biological motion in movies that presented these stimuli simultaneously, and people and geometry in movies that presented these stimuli simultaneously) by male adolescents and adults with ASD (N = 26) and age-matched males with typical development (TD; N =35).Wecomparedthese percentages between the two groups (ASD and TD) and with scores on the social responsiveness scale (SRS).
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