Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6 The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Lee, Joo-Hyeon et al. “Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.” Cell 170, 6 (September 2017): 1149–1163 © 2017 The Authors As Published http://dx.doi.org/10.1016/J.CELL.2017.07.028 Publisher Elsevier BV Version Final published version Citable link http://hdl.handle.net/1721.1/116555 Terms of Use Creative Commons Attribution 4.0 International License Detailed Terms http://creativecommons.org/licenses/by/4.0/ Article Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6 Graphical Abstract Authors Joo-Hyeon Lee, Tuomas Tammela, Matan Hofree, ..., Tyler Jacks, Aviv Regev, Carla F. Kim Correspondence
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[email protected] (C.F.K.) In Brief Heterogeneous mesenchymal cell populations in the lung play a central role in epithelial maintenance and alveolar differentiation. Highlights d Lgr5 and Lgr6 mark mesenchymal cells in adult lungs d Single-cell transcriptome analysis defines mesenchymal heterogeneity d Distinct mesenchymal niches drive airway and alveolar differentiation d Wnt activity affects epithelial differentiation specified by mesenchymal cells Lee et al., 2017, Cell 170, 1149–1163 September 7, 2017 ª 2017 The Authors. Published by Elsevier Inc. http://dx.doi.org/10.1016/j.cell.2017.07.028 Article Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6 Joo-Hyeon Lee,1,2,3,4,5,* Tuomas Tammela,6 Matan Hofree,7 Jinwook Choi,4 Nemanja Despot Marjanovic,6 Seungmin Han,4,8 David Canner,6 Katherine Wu,6 Margherita Paschini,1,2,3 Dong Ha Bhang,9 Tyler Jacks,6,10 Aviv Regev,6,7,10 and Carla F.