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Cancer Consortium (Consortium) Brings Together More Than 450 Members with Research Interests in Basic, Clinical and Public Health Sciences Related to Cancer

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Cancer Consortium (Consortium) Brings Together More Than 450 Members with Research Interests in Basic, Clinical and Public Health Sciences Related to Cancer SPECIFIC AIMS The Fred Hutchinson/University of Washington Cancer Consortium (Consortium) brings together more than 450 members with research interests in basic, clinical and public health sciences related to cancer. The goal of the Consortium is the elimination of cancer through more effective prevention, diagnostics and treatment, deriving from fundamental insights into the biology of the disease.The extensive interdisciplinary collaboration among the partner institutions in the cancer research disciplines of basic, clinical, and public health sciences affords new opportunities to reduce suffering and mortality from cancer. Over the next grant period, the Consortium will seek to: (1) Continue its leadership in cellular immunotherapy, with the goal of making this therapeutic platform the standard of care for many malignancies; (2) Build on our outstanding strengths in cancer basic biology to increase collaborative translational research, including using genomic and epigenomic technologies to develop effective prognostic tests for solid tumor cancers, applying protein engineering to novel cancer therapeutics, and developing robust mouse models of cancer for rapid screening of drug response prior to therapeutic intervention; (3) Expand our pioneering efforts to reduce the global burden of cancer through translational research on infection-related malignancies, application of global disease surveillance data, and unique international partnerships in Africa (Uganda and South Africa) and more recently China to establish robust platforms to improve our understanding of the spectrum of cancer biology and disease worldwide; (4) Lead research that supports provision of efficient, effective and cost-effective cancer care through research in health economcs, cancer outcomes and comparative effectiveness; and (5) Lead population-based research to uncover new insights into the link between obesity and cancer, and to reduce disparities in cancer risk, outomes and access to care in underserved populations. OVERALL COMPONENT PART I: DIRECTORS OVERVIEW The Fred Hutchinson/University of Washington Cancer Consortium was established in 2002 to build upon the complementary strengths and resources of three partner institutions: the Fred Hutchinson Cancer Research Center, which had been an NCI-designated Comprehensive Cancer Center since 1976, the University of Washington, which had significant strength in cancer care and laboratory sciences, and Seattle Children’s, the region’s major pediatric academic center. In 2008, the Seattle Cancer Care Alliance, the cancer treatment center founded and equally co-owned by the three institutions, was formally added as a fourth partner. The Consortium’s total funding base (direct dollars) is $389M, of which $87.5M is from the NCI, $98.1M from the other NIH institutes and $17.2M is other peer-reviewed funding. HIV grants and other non-cancer grants have been excluded from the funding base, except for the portion of some grants that is cancer-relevant. During this period, membership has grown by 10% to 464, despite a tightening of membership criteria. In the most recent year, there were 412 therapeutic clinical trials that accrued 958 local subjects. 31% of these trials were investigator initiated and 19% were Phase I. The ratio of accruals to newly registered patients was 23%. The Consortium serves a catchment area of 13 counties in Western Washington. This equates to the region in which 70 percent of our patients reside. As the only NCI-designated comprehensive cancer center in a five- state region (Washington, Wyoming, Alaska, Montana and Idaho), we not only seek to serve the health needs of the catchment area through research, training and outreach, but also to ensure high impact in the region. The Consortium continues to build upon historic strength in basic cancer biology, immunotherapy, population based research, health care outcomes and economics and global health. It is well poised to continue its exceptional level of research in these areas. The CCSG continues to have a high impact at our center, fostering new inter-institutional collaborations, strengthening the translational research platform, and intensifying research efforts on problems of the catchment area. Partner institutions committed nearly $580M in institutional support during the project period, including investment in the clinical research infrastructure and solid tumor translational research. The partners were involved in the appointment of Larry Corey, MD, as Consortium Director and as President and Director of FHCRC in 2011. Dr. Corey succeeded Lee Hartwell, PhD, who led the FHCRC and the Consortium for 13 years. Dr. Corey has worked with faculty and the Board of Trustees at FHCRC to conduct a comprehensive review of FHCRC scientific priorities, and, in collaboration with leaders of the partner institutions, the scientific priorities of the Consortium. The alterations and adjustments of many of the programs outlined in this proposal are a direct result of these processes. As described later, major scientific advances during the project period include: Mapping functional elements in the genome that may serve as therapeutic targets for cancer; Engineering computationally designed proteins that inhibit tumor proteins; Novel tools to analyze the human immune cell genomic repertoire with utility to improve cancer prognostic tests; Identification of mechanisms of chemotherapy resistance that may lead to improvements in therapy; A gene therapy approach with potential to improve glioblastoma treatment; Strategies to improve management of Merkel cell carcinoma; Immunotherapies using genetically engineered T cells for hematologic and solid tumor cancers; An effective strategy for engraftment using cord blood transplantation; Multiple contributions that are reducing mortality from hematopoietic stem cell transplantation; Determination of the impact of dietary supplements (vitamin E) on prostate cancer; Assessing the economic return of a major national prevention trial; The first global study on the levels, trends and impact of cancer in the developed and developing world. Rationale for Formation of the Consortium The structure of the Consortium is shown in Figure 1. For over 40 years, FHCRC and UW School of Medicine (UWSOM) have had a joint clinical research program. One individual serves as both the director of FHCRC’s Clinical Research Division and as head of Medical Oncology at UWSOM. In 2013, Fred Appelbaum stepped down from these roles following his appointment as Deputy Director of FHCRC and the Consortium. A national search jointly conducted by all Consortium partners is underway to identify a single Figure 1 individual to fill these roles as it is apparent that a unified model has served the institutions well. Many faculty hold secondary appointments at one or more of the other partner institutions. 77% of the Consortium faculty based at FHCRC and 26% of UW-based faculty hold secondary appointments at the other institution. All Children’s faculty have appointments in the UW Department of Pediatrics. In 1994, the FHCRC and UW signed a formal agreement to pursue joint cancer research, care and education and in 1998, FHCRC and UW entered into an agreement with Children’s to create and then operate a cancer treatment center. The three institutions are equal partners and co-owners. Known as the Seattle Cancer Care Alliance (SCCA), its goal is to promote, enhance and integrate the cancer research, teaching and clinical programs of the partner institutions. Thus, the partners are united financially and in patient care through the SCCA. The CCSG binds their investigative interests, uniting their oncology research programs. Further cementing this integration, Dr. Appelbaum has been SCCA Executive Director since its founding. The successor to his FHCRC and UW roles will also assume Dr. Appelbaunm’s SCCA role when he steps down from that position. Deep collaborations in graduate education also exist. These include a graduate program that is jointly administered by FHCRC and UW and spans the biological sciences at the two institutions. FHCRC faculty have long participated in UW School of Public Health graduate education as teachers and advisors. They also participate in University training grants in epidemiology, biostatistics and cancer prevention. Several T32s support trainees at both FHCRC and UW, and faculty from both institutions serve as PIs. Since FHCRC’s founding in 1972 there has been joint hematology/oncology fellowship training with UWSOM, and there are also joint fellowship programs in pediatric oncology and other clinical subspecialties. In 2002, the three institutions signed an MOU to form the Fred Hutchinson/University of Washington Cancer Consortium. The Consortium built upon the FHCRC as an NCI-designated Comprehensive Cancer Center, while adding the vital research and resources of the new partners. In 2008, at the time of the last CCSG renewal, SCCA was formally added to the cancer center designation. Scientific Contributions of Member Institutions Fred Hutchinson Cancer Research Center (FHCRC). FHCRC was founded in 1972, received its first CCSG in 1973, and was designated a comprehensive cancer center in 1976. Today, it has more than 200 faculty and an annual research budget (total costs) of $400M. The institution has always emphasized research on the biology, prevention, diagnosis and treatment of cancer and its founding premise has been to eliminate cancer as a cause of human suffering and death. 205 Consortium
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