Widge – Curriculum Vitae

Harvard Medical School/Harvard School of Dental Medicine Format for the Curriculum Vitae Date Prepared: 12/20/2015 Name: Alik Sunil Widge Office Address: 149 13th St, Room 2625, Charlestown, MA 02129 Home Address: 62 Liberty Ave, Somerville, MA 02144 Work Phone: 617-643-2580 Work Email: [email protected] Work FAX: 617-726-4078 Place of Birth: Allentown, PA, USA

Education

08/1995 – BA (summa cum laude, Computer Science & Cognitive Dartmouth College 06/1999 Phi Beta Kappa, High Science Honors in major) 07/1999 – MD (Alpha Omega Medical Scientist Training University of Pittsburgh 12/2008 Alpha) Program 08/2001 – PhD (Yoky Matsuoka & Carnegie Mellon 01/2007 Kaigham Gabriel) University

Postdoctoral Training

06/2009 – Resident Psychiatry 05/2013 06/2009 – Postdoctoral Chet Moritz (Biophysics, University of Washington

05/2013 Researcher Neurophysiology, Rehabilitation Medicine) 07/2013 – Research Fellow Darin Dougherty (Interventional Massachusetts General 06/2014 Psychiatry) Hospital 07/2013 – Research Fellow Earl Miller (Picower Institute for Massachusetts Institute of 06/2015 Learning & Memory) Technology

Faculty Academic Appointments

4/2014 – Instructor Psychiatry Harvard Medical School

Appointments at Hospitals/Affiliated Institutions

4/2014 – Assistant Psychiatry Massachusetts General Hospital

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Other Professional Positions

09/1997 – Undergraduate Research Assistant (parallel Dartmouth College, Computer Science 06/ 1999 projects with Daniela Rus and Bruce Dept. Randall Donald) 09/1996 – Lead Programmer World Market Watch, Woodstock, VT 09/1997 02/2009 – Volunteer Physician SHARE India / Bhoruka Charitable Trust, 04/2009 Rajasthan, India 02/2010 – Consultant (Market Research / Business Assay Dynamics, Seattle, WA 01/2011 Plan Development)

Committee Service Local 2007 - 2009 Propel Pittsburgh Commission City of Pittsburgh

2009 - 2013 Psychiatry Residency Education Steering University of Washington Committee 2013 Quality Improvement Subcommittee 2012 - 2013 Graduate Medical Education Committee University of Washington 2014 - Psychiatric Neurosurgery Committee Massachusetts General Hospital

National and International 2001 - 2003 Electronic Residency Application System Assn of American Medical Colleges

Advisory Committee 2011 - 2013 Psychiatry Residency Review Committee Accreditation Commission for Graduate Medical Education 2012 - 2014 Psychiatry Milestones Working Group Accreditation Commission for Graduate Medical Education Professional Societies 1999 - Sigma Xi

1999 - American Association for the Advancement of Science 1999 - American Medical Association 2002 – 2004 American Medical Political Action Cmte, Board of Directors 2003 – 2004 Chair, Medical Student Section Task Force on Medical Education Debt 2004 – 2006 Chair, Medical Student Section (includes Chair-Elect, Immediate Past Chair) 2006 – 2009 Medical Student Section Committee on Long-Range Planning 2013 – 2016 Council on Long-Range Planning & Development 2014 Judge, Resident Research Symposium 1999 - 2009 Pennsylvania Medical Society 2001 - 2003 Pennsylvania Medical Political Action 2 Widge – Curriculum Vitae

Cmte, Board of Directors 2005 – 2009 Alternate Delegate to American Medical Association 2007 – 2009 Patient Advocacy Executive Council 2002 - Society for 2002 – 2006 National Assn of Graduate-Professional Students 2002 – 2004 Legislative Director 2006 – 2008 American Physician Scientists Association 2007 – 2008 Public Relations Committee 2008 – 2013 American College of Medical Quality 2007 - 2013 International Neuroethics Society 2009 - American Psychiatric Association 2010 – 2011 Deputy Representative, Assembly 2011 – 2013 Board of Trustees 2015 – Corresponding Member, Council on Research 2009 – 2013 Washington State Psychiatric Association 2010 – 2013 Executive Council 2009 – 2013 Washington State Medical Association 2011 – 2013 Resident Delegate to American Medical Association 2012 - Society for Biological Psychiatry 2015 – Annual Meeting Program Committee 2013 - Massachusetts Psychiatric Society 2013 - Massachusetts Medical Society 2013 – 2015 Resident/Fellow Delegate to American Medical Association 2014 Judge, Research Poster Symposium 2015 – Legislative Committee (alternate) Grant Review Activities 2006 – 2007 Scholarship/award committees (ad hoc) American Medical Association Foundation

2011 – 2012 Research Grants Review Committee (ad University of Washington Housestaff hoc) Association 2012 Junior Investigator Grants Review Romanian National Council for Scientific Committee (ad hoc) Research 2014 Graduate Research Fellowship Program National Science Foundation Review Committee (panelist member) Editorial Activities Ad Hoc Reviewer Journal of Journal of Neuroscience Neurosurgery

Regular Reviewer Academic Psychiatry

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Brain-Computer Interfaces Depression & Anxiety Experimental Neurology ("Recognized Reviewer") Frontiers in Neural Circuits Journal of Affective Disorders Journal of Biomedical Materials Research Journal of Graduate Medical Education (“GME Focus” summarizer) Journal of Neurophysiology Scientific Reports

Honors and Prizes

1995 National Merit Scholar National Merit Scholarship Academic excellence as Corporation high school student 1995 Eagle Scout Boy Scouts of America Character, community

service, and achievement 1999 John J. Kemeny Dartmouth College Innovative undergraduate Computing Prize - achievement (JIGSAW Innovation algorithm) 1999 John J. Kemeny Dartmouth College Software architecture in an Computing Prize – undergraduate project System Design (Agent Scheme) 1999 Presidential Scholar Dartmouth College Undergraduate research 2011 Outstanding Resident National Institute of Mental Health Research potential Award 2012 Brain Camp Scholar National Institute of Mental Health Research potential 2012 Research Colloquium American Psychiatric Association Research potential for Junior Investigators 2013 BRAIN Scholar American Association of Directors Research/teaching of Psychiatric Residency Training 2013 Travel Award NSF Center for Sensorimotor Neural Engineering (University of Washington) 2013 Resident Recognition American Psychiatric Association Service to profession, Award patients, scholarship 2014 Career Development NIMH/Stanford/U of Pittsburgh Research potential Institute for Psychiatry 2014 Career Development Anxiety & Depression Association Research potential Leadership Program of America 2015 Travel Award Society of Biological Psychiatry Research potential 2015 Finalist, Career Awards Burroughs Wellcome Fund Research potential for Medical Scientists 2015 Travel Award American College of Research potential Neuropsychopharmacology 2015 Participant, Champions White House Office of Science & Specific expertise of Change: Precision Technology Policy Medicine 2015 Clinical Research Day Massachusetts General Hospital Leadership of 4 Widge – Curriculum Vitae

Team Award interdisciplinary team

Report of Funded and Unfunded Projects Funding Information Past 2002 – 2005 Conductive Polymer “Molecular Wires” for Neuro-Robotic Interfaces National Defense Science & Engineering Graduate Fellowship Mentored Investigator, with Yoky Matsuoka Graduate fellowship (tuition/stipend) to develop a new electrode technology for chronic neural recording and stimulation. Demonstrated that single-molecule nanowires could be bound onto conventional metal electrodes and that they could insert into a cell membrane for chronic intracellular recording.

2005 – 2008 Polymer “Molecular Wires” for Neuroprosthetic Electrodes NINDS / F30 NS051866 Mentored trainee ($160,000 direct costs), with Yoky Matsuoka Graduate fellowship for further development of nanowire electrode technology, particularly characterization of biocompatibility and supercomputer simulations of mechanism of membrane action. Fellowship also funded completion of MD/PhD training.

2012 – 2013 Closed-Loop Neurostimulation for Psychiatric Disorders NSF Center for Sensorimotor Neural Engineering Seed Grant Mentored PI ($12,000 direct costs), with Chet Moritz Development of a rodent model for brain stimulation that is controlled and volitionally triggered by a subject’s own brain activity. First proof of concept towards a patient- controllable implantable neuromodulation system.

2013 – 2015 Picower Clinical Neuroscience Fellowship Mentored Fellow ($40,000 direct costs plus stipend), with Darin Dougherty and Earl Miller Competitive fellowship grant for translational work between MIT basic neuroscience labs and MGH clinical brain stimulation group, bridging a gap between primate and human affective regulation neuroscience.

Current 2014 – 2019 Transdiagnostic Restoration of Affective Networks by Systematic, Function-Oriented Real-time Modeling and Deep Brain Stimulation (TRANSFORM DBS); co-PIs Darin Dougherty and Emad Eskandar Defense Advanced Research Projects Agency, BAA-14-09 Program Management and System Integration ($756,765 salary support) Major multi-year, multi-PI effort developing novel deep brain stimulation technology and algorithms for biomarker detection and closed-loop stimulation across several psychiatric disorders. My role focuses on integrating software and hardware from multiple labs into a usable and clinically relevant system.

2015-2017 Responsive, Subject-Controlled Limbic Neurostimulation

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Brain & Behavior Research Foundation (NARSAD Young Investigator research grant) Principal Investigator ($65,000 direct costs) This project aims to produce preliminary data for a responsive neurostimulator that enhances emotion-regulating capacity by boosting the gain of a fronto-limbic pathway.

2015-2016 Manipulating Top-Down Emotion Regulation Through Oscillatory Synchrony MIT-MGH Grand Challenge 3: Neuroscience Principal Investigator ($21,739 direct costs) This project aims to demonstrate methods for changing theta-band oscillatory synchrony between two brain areas.

2015-2016 Engineering Brain Circuit Connectivity to Improve Emotion Regulation Bipolar Disorder Fund for Neuroscience Research at Harvard University, supported by Kent and Liz Dauten Principal Investigator ($86,957 direct costs) This project aims to study and alter the influence of gamma-band local field potentials in the rat prefrontal cortex on related potentials in the amygdala during tasks that model emotion regulation in bipolar disorder.

Current Unfunded Projects

2015 – Patient Perspectives on Psychiatric Neuromodulation I am coordinating a cross-university team of researchers and ethicists conducting a series

of patient interviews to understand patients/users' perspectives on existing and proposed psychiatric brain stimulation devices.

Report of Local Teaching and Training Teaching of Students in Courses 1996 Phlebotomy Lehigh Valley Medical Center Nursing students Designed, filmed, and programmed interactive laserdisc course that replaced classroom didactics. 1998 Artificial Intelligence (CS 44) Dartmouth College Undergraduates Weekly small-group sessions and lab hours, 10 weeks 1998 Structure & Interpretation of Computer Dartmouth College Programs (CS 18) Undergraduates (required major course) Weekly small-group sessions (independently designed lectures), lab hours, and support of programming tools, 10 weeks 2002 Fundamentals of Carnegie Mellon University (18-220) Undergraduates (required major course) Weekly lab sessions with lecture, problem set design, homework/lab grading, 12 weeks 2015 Systems Neuroscience (9.011) Massachusetts Institute of Technology

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Graduate students (required core course) Series of three lectures, plus discussions and mentoring of students outside of class.

Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs) 2012 – 2013 ACGME Competencies, Organized University of Washington Medicine, and Residency Survival PGY1 residents (required didactics) Three one-hour lectures 2015 Deep Brain Stimulation and Vagus Nerve Massachusetts General Hospital Stimulation PGY3 residents (didactics) One-hour lecture

Clinical Supervisory and Training Responsibilities

2009 – 2011 Medical student supervision & informal Daily, 1-2 hours focused effort teaching / University of Washington Medical Center, Harborview Medical Center, VA Puget Sound Laboratory and Other Research Supervisory and Training Responsibilities

2013 – Supervision of research assistants / MGH Combined 6 hrs/wk of supervision of staff Division of Neurotherapeutics of 3-5 post-baccalaureate RAs. Included career mentorship, technical planning, training in research methods. 2013 – Supervision of MD-PhD students / MIT 4 hrs/wk supervising and mentoring MD- Picower Institute for Learning & Memory PhD students working in the Miller Lab. Includes training in research techniques, review of plans for clinical relevance, review of materials for publication. 2014 – Supervision of postdoctoral fellows / Hiring, training, and direct supervision of 3 TRANSFORM DBS program postdoctoral fellows, with emphasis on computational and statistical modeling of brain and behavior. Total 9 hrs/wk. Formally Supervised Trainees 2011 – 2012 Behnum Habibi, medical student / Case Prepared and presented an IEEE conference Western Reserve University paper; pursuing residency in psychiatry. 2013 – 2015 Roman Loonis, MD-PhD student / Student continues in BU MD-PhD program, Massachusetts Institute of Technology is preparing NINDS F30. 2013 – 2015 Andrew Corse, medical student / University Contributed to multiple papers/posters, now of Vermont medical student. 2013 – 2015 Amanda Arulpragasam, graduate student / Contributed to multiple papers/posters and Emory University book chapters. Now a clinical psychology graduate student. 2014 – 2016 Sam Zorowitz, undergraduate research Presented at multiple national meetings, assistant / Massachusetts General Hospital author on multiple journal papers. 2014 Ernesto Licon, medical student / Texas Second author on published journal paper. A&M University 2014 - Angelique Paulk, postdoctoral fellow / Co-first author on IEEE conference paper, 7 Widge – Curriculum Vitae ongoing Massachusetts General Hospital other works in progress. 2015 - Ishita Basu, postdoctoral fellow / Preparing journal paper for submission. ongoing Massachusetts General Hospital 2015 - Jacob Donoghue, MD-PhD student / Continues in HMS MD-PhD program, ongoing Harvard-MIT Division of Health Sciences preparing F30, likely for NINDS. & Technology 2015 - Ali Yousefi, postdoctoral fellow / First author of IEEE conference paper, ongoing Massachusetts General Hospital other papers in preparation. Local Invited Presentations 2012 Patient-Controlled Psychiatric Brain Stimulation / Grand Rounds Department of Psychiatry, Harborview Medical Center 2014 Neurotherapeutic Interventions for Psychiatric Diseases / Charles F. Johnson Memorial Lecture Lawrence Memorial Hospital, Medford, MA 2014 Electro-Magnetic Brain Stimulation for Psychiatric Illness: Progress, Challenges, and Opportunities / Medical Electronic Device Realization Center Seminar Massachusetts Institute of Technology, Cambridge, MA 2014 TRANSFORM DBS: Developing Next-Generation Psychiatric Brain Stimulation / Magnetoencephalography Research Group Seminar, Athinoula A. Martinos Center, Charlestown, MA 2014 Closing the Loop in Psychiatric Brain Stimulation / Affective & Translational Neuroscience Seminar, McLean Hospital, Belmont, MA 2014 TRANSFORM DBS: Developing Next-Generation Psychiatric Brain Stimulation / Center for Brain/Mind Medicine Seminar, Brigham & Womens Hospital, Boston, MA 2014 The Neuroscience of Learning, Motivation, and Consumption / Brain Rewards and Climate Change: The Neurobiology of Simplification, Harvard Center for the Environment, Cambridge, MA 2015 Neurosurgical Interventions for Obsessive-Compulsive Disorder / McLean Hospital OCD Massachusetts Lecture Series, Belmont, MA 2015 TRANSFORM DBS: Developing Next-Generation Psychiatric Brain Stimulation / PTSD Innovation Seminar, Red Sox/MGH Home Base Program, Boston, MA 2015 Deep Brain Stimulation and Surgical Interventions for Treatment-Resistant Mood and Anxiety Disorders / Grand Rounds, Bournewood Hospital, Boston, MA 2015 Deep Brain Stimulation for Major Depression / Patient & Family Research Day, Massachusetts General Hospital, Boston, MA 2015 Deep Brain Stimulation for Psychiatric Disorders / NEURONS Evening Seminar, Northeastern University, Boston, MA 2015 TRANSFORM DBS: Psychiatric Brain Stimulation and Neurosecurity / CyberMedRx Conference, Microsoft, Cambridge, MA 2015 Neurosurgical Interventions for Treatment-Resistant Mood and Anxiety Disorders / Psychiatry Grand Rounds, Boston Medical Center, Boston, MA

Report of Regional, National and International Invited Teaching and Presentations Invited Presentations and Courses No presentations below were sponsored by outside entities. 8 Widge – Curriculum Vitae

International 2015 Neural Engineering and Neuro-Psychiatric Disorders: Integrated Algorithmic and Hardware Design of a Closed-Loop Brain Stimulation System / Symposium Co-Chair (Abstract) IEEE Engineering in Medicine & Biology Conference, Milan, Italy 2015 Closing the Loop for Deep Brain Stimulation / Symposium Presentation (Abstract) Society of Biological Psychiatry Annual Meeting, Toronto, Canada

National – Area of Excellence 2002 – 2004 Nerve Chips: Bridging Mind and Machine / Visiting Professorship Dartmouth College, Hanover, NH 2005 – 2006 Neural Interfaces: Bridging Mind and Machine / Visiting Professorship Dartmouth College, Hanover, NH 2006 Neural Interfaces: Current State of the Art / Platform Presentation Dartmouth Polytrauma Conference, Hanover, NH 2010 – 2011 Neural Interfaces: Bridging Mind and Machine / Visiting Professorship Dartmouth College, Hanover, NH 2012 Patient-Controlled Psychiatric Brain Stimulation / Research Seminar Brain Stimulation Lab, Medical University of South Carolina, Charleston, SC 2012 Patient-Controlled Psychiatric Brain Stimulation / Research Seminar Neurotherapeutics Group, Massachusetts General Hospital, Boston, MA 2012 Patient-Controlled Psychiatric Brain Stimulation / Research Seminar Department of Psychiatry, Dartmouth-Hitchcock Medical Center, Hanover, NH 2014 Neurosurgical Interventions for Intractable OCD / Platform Presentation Anxiety & Depression Association of America Annual Mtg, Chicago, IL 2014 Closing the Loop for Psychiatric Brain Stimulation / Invited Presentation DFG-NSF Collaborative Neuroscience Workshop, Arlington, VA 2015 Closing the Loop for Psychiatric Brain Stimulation / Research Seminar Stanford University Department of Neurological Surgery 2015 Closing the Loop in Psychiatric Brain Stimulation / Grand Rounds University of Florida Department of Neurology 2015 Emotion, Cognition, and Oscillations / Invited Presentation NIH Non-Invasive Brain Stimulation Workshop, Chicago, IL 2015 Closing the Loop in Psychiatric Brain Stimulation / Kavli Brain Seminar University of Washington Center for Sensorimotor Neural Engineering 2015 Deep Brain Stimulation for Mood and Anxiety Disorders: Present and Future / Grand Rounds University of Washington Department of Psychiatry National – Supporting Activity 2013 DSM-5 for the Member-in-Training / Platform Presentation American Psychiatric Assn Annual Mtg, San Francisco, CA 2013 The Path to Lifetime Achievement: The Role of the APA in Career Success Stories / Invited Panelist American Psychiatric Assn Annual Mtg, San Francisco, CA 2013 Changes in Psychiatric Education: The Psychiatry Milestones and the Next Accreditation System of the ACGME / Invited Presentation American Psychiatric Assn Annual Mtg, San Francisco, CA 9 Widge – Curriculum Vitae

2013 – 2014 Introduction to the Practice of Medicine / Module Consultant American Medical Association, Online Curriculum 2014 Health Care Trends Worth Watching / Invited Presentation American Medical Association Interim Meeting, Dallas, TX Regional 2013 – 2015 Brain-Computer Interfaces: Bridging Mind and Machine / Visiting Professorship Dartmouth College, Hanover, NH

Report of Clinical Activities and Innovations Current Licensure and Certification

2009 – 2011 Washington Limited Trainee License 2012 – 2013 Washington Full Medical License 2013 - DATA Waiver for Office-Based Opiate Substitution Therapy 2013 - Massachusetts Full Medical License 2013 - Board Certification in General Psychiatry Practice Activities

04/14 - Psychiatry (focus on Massachusetts General Hosp 16 hours/month interventional, DBS) Charlestown, MA 01/14 - On-Call Psychiatry Bournewood Hospital 6 hours/month Brookline, MA 02/14 - On-Call Psychiatry Lowell Treatment Center 6 hours/month Lowell, MA

Report of Technological and Other Scientific Innovations

Hybrid System for Published, DOI 10.1080/2326263X.2014.912885. Patent filed, application Treating Mental and 61/984466. Emotional Disorders with Method for combining a “brain decoding” approach to emotional state estimation Responsive Brain with measurements of patients’ intentions or immediate clinical needs, along with Stimulation evidence that such a system would be necessary for a closed-loop psychiatric brain (2013) stimulator to function. In further development in our laboratory.

Method for Cross- Publication submitted. Patent filed, application 61/984416. Diagnostic Identification and Method for patient-specific diagnosis of mental illness using a novel, domain- Treatment of oriented classification that is then specifically linked to treatment via targeted Neurologic Features electro-magnetic brain stimulation. Invention is being used as part of the Underpinning TRANSFORM DBS project, with proof of efficacy expected in 2016-7. Mental and Emotional Disorders (2013)

Methods For Publication in press. Patent filed, application 62/186470. Measuring Mental 10 Widge – Curriculum Vitae

Flexibility From Method for identifying a patient's level of mental flexibility, measured at second to Brain and Behavior sub-second timescales using psychophysical tasks. We have shown that this state and Altering Same changes in response to deep and cortical brain stimulation, suggesting that it could Through Neuro- form the basis of a closed-loop stimulation system. Stimulation (2015)

A System and Publication in press. Patent filed, application 62/200742. Method for Recovering an Method for identifying a patient's level of fear or other emotional arousal state in Emotional State response to stimuli in the environment, resolved to sub-second timescales. This From Physiologic represents a new method for identifying fear states from physiologic signals, Signals of Arousal particularly heart rate and skin conductance. The technique could be used as part of (2015) a closed-loop stimulation system to relieve fear.

Neural Stimulation Publication in press. Patent filed, application 62/1692495. and Recording Device (2015) Integrated combination of hardware, operating-system software, and neural stimulation control algorithms for monitoring and controlling the state of brain networks. Covers early version of the TRANSFORM DBS device.

Report of Scholarship Publications Peer reviewed publications in print or other media Research Investigations 1. Bailey-Kellogg C, Widge AS, Kelley J, Berardi M, Bushweller J, Donald BR. The NOESY Jigsaw: automated protein secondary structure and main-chain assignment from sparse, unassigned NMR data. Proceedings of the Fourth Annual International Conference on Computational Molecular Biology (RECOMB '00). 1:33-44.

2. Bailey-Kellogg C, Widge AS, Kelley J, Berardi M, Bushweller J, Donald BR. The NOESY Jigsaw: automated protein secondary structure and main-chain assignment from sparse, unassigned NMR data. J Comput Biol 2000; 7 (3/4): 537-558. PMCID: 11108478

3. Widge AS, Jeffries-El M, Lagenaur CF, Weedn VW, Matsuoka Y. Conductive polymer ‘molecular wires’ for neuro-robotic interfaces. Proceedings of the 2004 International Conference on Robotics and Automation (ICRA ‘04) 5:5058-5063.

4. Widge AS, Matsuoka Y. Conductive polymer ‘molecular wires’ increase conductance across artificial cell membranes. Proceedings of the 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEMBS ’04). 2:4330-43333.

5. Widge AS, Jeffries-El M, Cui X, Lagenaur CF, Matsuoka Y. Self-assembled monolayers of polythiophene conductive polymers improve biocompatibility and electrical impedance of neural electrodes. Biosens Bioelec 2007; 22(8):1723-1732. PMCID: 17015008

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6. Widge AS, Matsuoka Y, Kurnikova M. Computational modeling of poly(alkylthiophene) conductive polymer insertion into phospholipid bilayers. Langmuir 2007; 23(21):10672-10681. PMCID: 17867709

7. Widge AS, Matsuoka Y, Kurnikova M. Development and initial testing of an empirical forcefield for simulation of poly(alkylthiophenes). J Mol Graph Model 2008; 27(1):34-44. PMCID: 18485769

8. Widge AS, Avery DH, Zarkowski P. Previously reported EEG biomarkers of antidepressant medication response do not predict response to repetitive transcranial magnetic stimulation. Brain Stimul 2013; 6(6):929-931. PMCID: 23763894

9. Widge AS, Habibi BA, Moritz CT. Pilot study of cortical recording with synchronized limbic stimulation. 2013 IEEE Neural Eng Short Papers; 0577.

10. Widge AS, Moritz CT. Pre-frontal control of closed-loop limbic neuromodulation by rodents using a brain-computer interface. J Neural Engineering 2014; 11(2):024001. PMCID: 24608127

11. Fung LK, Akil M, Widge AS, Roberts LW, Etkin A. Attitudes toward neuroscience education among psychiatry residents and fellows. Academic Psychiatry 2014; 38(2):127-134. PMCID: 24493359

12. Widge AS, Dougherty DD, Moritz CT. Affective brain-computer interfaces as enabling technology for responsive psychiatric stimulation. Brain-Computer Interfaces 2014; 1(2):126-136.

13. Widge AS, Hunt J, Servis M. Systems-Based Practice and Practice-Based Learning for the general psychiatrist: old competencies, new emphasis. Academic Psychiatry 2014; 38(3):288-293. PMCID: 24711094

14. Benjamin S, Widge AS, Shaw K. Neuropsychiatric and neuroscience milestones for general psychiatry trainees. Academic Psychiatry 2014; 38(3):275-282. PMCID: 24715675

15. Fung LK, Akil M, Widge AS, Roberts LW, Etkin A. Attitudes towards neuroscience education in psychiatry from a national multi-stakeholder survey. Academic Psychiatry 2015; 39(2):139-146. PMCID: 25001432

16. Faghih RT, Stokes PA, Marin M-F, Zsido RG, Zorowitz S, Rosenbaum BL, Song DH, Milad MR, Dougherty DD, Eskandar EN, Widge AS, Brown EN, Barbieri R. Characterization of fear conditioning and fear extinction by analysis of electrodermal activity. Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2015). 2015;7808-7813.

17. Bjune CK, Marinis TF, Brady JM, Moran J, Wheeler JJ, Sriram TS, Parks PD, Widge AS, Dougherty DD, Eskandar EN. Package architecture and component design for an implanted neural stimulator with closed loop control. Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2015). 2015;7825-7830

18. Hamilton LH, McConley MW, Angermueller KWK, Goldberg DH, Corba M, Kim LY, Moran J, Parks PD, Chin S, Widge AS, Dougherty DD, Eskandar EN. Neural signal processing and closed- loop control algorithm design for an implanted neural recording and stimulation system. Proceedings 12 Widge – Curriculum Vitae

of the 37th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2015). 2015;7831-7836.

19. Wheeler JJ, Baldwin K, Kindle A, Guyon D, Nugent B, Segura C, Rodriguez J, Czarnecki A, Dispirito HJ, Lachapelle J, Parks PD, Moran J, Widge AS, Dougherty DD, Eskandar EN. An implantable 64-channel neural interface with reconfigurable recording and stimulation. Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2015). 2015;7837-7840.

20. Deng X, Faghih RT, Barbieri R, Paulk AC, Asaad WF, Brown EN, Dougherty DD, Widge AS, Eskandar EN, Eden UT. Estimating a dynamic state to relate neural spiking activity to behavioral signals during cognitive tasks. Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2015). 2015;7808-7813.

21. Yousefi A, Paulk AC, Deckersbach T, Dougherty DD, Eskandar EN, Widge AS*, Eden UT*. Cognitive state prediction using an EM algorithm applied to gamma distributed data. Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2015). 2015;7819-7824.

22. Makris N, Rathi Y, Mouradian P, Bonmassar G, Papadimitriou G, Ing WI, Yeterian EH, Kubicki M, Eskandar EN, Wald LL, Fan Q, Nummenmaa A, Widge AS, Dougherty DD. Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD). Brain Imaging and Behavior. October 2015:1-14.

23. Widge AS, Licon E, Zorowitz S, Corse A, Arulpragasam AR, Camprodon JA, Cusin C, Eskandar EN, Deckersbach T, Dougherty DD. Predictors of hypomania during ventral capsule/ventral striatum deep brain stimulation. J Neuropsychiatry Clin Neurosci. In press.

24. Dougherty DD, Chou T, Corse AK, Arulpragasam AR, Widge AS, Cusin C, Evans KC, Greenberg BD, Deckersbach T. Acute deep brain stimulation changes in regional cerebral blood flow in obsessive-compulsive disorder. J Neurosurgery. In press.

25. Bjune CK, Marinis TF, Sriram TS, Brady JM, Moran J, Parks PD, Widge AS, Dougherty DD, Eskandar EN. Packaging architecture for an implanted system that monitors brain activity and applies therapeutic stimulation. Proceedings of the IMAPS 48th Annual International Symposium on Microelectronics. In press.

26. Widge AS, Zorowitz S, Link K, Miller EK, Deckersbach T, Eskandar EN, Dougherty DD. Ventral capsule/ventral striatum deep brain stimulation does not consistently diminish occipital cross- frequency coupling. Biological Psychiatry. 2016; accepted.

27. Widge AS, Ellard K, Paulk AC, Basu I, Yousefi A, Zorowitz S, Gilmour A, Afzal A, Deckersbach T, Cash SS, Kramer MA, Eden UT, Dougherty DD, Eskandar EN. Treating refractory mental illness with electrical brain stimulation: progress towards a patient-specific transdiagnostic approach. Exp Neurol. Invited; revision under review.

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Reviews and Commentaries 28. Widge AS, Goutman S, Levine A, Ravindranath D, Shapiro LT, Walsh W, Watson M, Zimmerman H. Effects of medical education debt on access to health care. CONTEXT 2006; 1:22-32.

29. Widge AS. Advocacy and the aspiring academic psychiatrist. Am J Psych: Residents' Journal 2012; 7(6):11.

30. Widge AS, Avery DH, Zarkowski P. Methodology and the limits of QEEG: Reply to Olbrich & Arns. Brain Stimul 2014; 7(1):148-149. PMCID: 24252322

31. Widge AS, Schultz H. Opportunities and challenges: Residents’ perspectives on the Next Accreditation System in psychiatry. Academic Psychiatry 2014; 38(3):303-304. PMCID: 24664610.

32. Franklin R, Zorowitz S, Corse AK, Widge AS, Deckersbach T. Lurasidone for the treatment of bipolar depression: an evidence-based review. Neuropsych Dis Treatment 2015; 2015(11): 2143-252.

33. Widge AS, Dougherty DD. Deep brain stimulation for treatment-refractory mood and obsessive- compulsive disorders. Current Behavioral Neuroscience Reports. 2015 Dec;2(4):187–97

34. Widge AS, Sahay A. Closing the loop in deep brain stimulation for psychiatric disorders: lessons from motor neural prosthetics. Neuropsychopharmacology Reviews. 2016;41(1):379–80.

35. Widge AS, Deckersbach T, Eskandar EN, Dougherty DD. Deep brain stimulation for treatment- resistant psychiatric illnesses: what has gone wrong and what should we do next? Biological Psychiatry. 2016; in press.

Clinical Communications 36. Widge AS, Tomycz ND, Kanter AS. An atypical presentation of cauda equina syndrome from inferior vena cava thrombosis: case report and review of the literature. J Neurosurg: Spine 2009; 10(3):257-260. PMCID: 19320586

37. Widge AS, Agarwal P, Giroux M, Farris S, Hebb AO, Kimmel RJ. Psychosis from subthalamic nucleus deep brain stimulator lesion effect. Surg Neurol Int 2013; 4:7. PMCID: 3589868

Non-peer reviewed scientific or medical publications/materials in print or other media 38. Widge AS, Moritz CT, Matsuoka Y. Direct neural control of anatomically correct robotic hands. In: (B+H)CI: The Human in Brain-Computer Interfaces and the Brain in Human-Computer Interaction. Tan DS, Nijholt A (eds.) Springer; 2010, pp105-119.

39. Widge AS. “Residents Forum”. 12-column monthly series in Psychiatric News, 2012-2013.

40. Widge AS (contributor). NextGen VOICES 8. Science 2013; 342(6154):36-38.

41. Heffron E. “Calibration”. One-act play on neural interfaces and closed-loop brain stimulators, based in part on my research and written with my scientific input. First performed June 2014.

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42. Widge AS, Arulpragasam AR, Deckersbach T, Dougherty DD. Emerging Trends in Deep Brain Stimulation for Psychiatric Disorders. In: Emerging Trends in the Social and Behavioral Sciences. Scott R, Kosslyn S (eds.) Hoboken, NJ: John Wiley and Sons. 2015.

43. Widge AS, Dougherty DD. Deep Brain Stimulation for Refractory Psychiatric Illness. In: Deep Brain Stimulation Management, 2nd Edition. Marks WJ Jr. (ed.) Cambridge, UK: Cambridge University Press. In press.

44. Widge AS, Moritz CT. Closed-Loop Stimulation in Emotional Circuits for Neuro-Psychiatric Disorders. In: Closed Loop Neuroscience. El Hady A (ed.) San Diego, CA: Elsevier. In press.

Clinical Guidelines and Reports

Diagnostic & Statistical Manual of Mental Disorders, 5th Edition (DSM-5). American Psychiatric Association (2013). Internationally recognized and relied upon as the premier handbook of psychiatric diagnostic criteria. As voting member of Board of Trustees, shared responsibility for proofreading and approving all criteria, as well as debating inclusion/placement of controversial diagnoses.

The Psychiatry Milestone Project. Accreditation Council for Graduate Medical Education (2013). Benchmark document of expectations for curriculum and progression in all psychiatry training. Foundation for ACGME’s Next Accreditation System, implemented in 2013-2014 for all medical specialties. As member of Working Group, developed and edited numerous milestones and assessments.

Thesis

Widge AS. Self-Assembled Monolayers of Polythiophene "Molecular Wires": A New Electrode Technology for Neuro-Robotic Interfaces. CMU-RI-TR-07-03, Robotics Institute, Carnegie Mellon University, January, 2007

Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings (3 prior years) Widge AS, Miller EK, Deckersbach T, Dougherty DD. Increased cognitive flexibility as a potential mechanism of ventral capsule/ventral striatum deep brain stimulation: a combined behavior/EEG pilot study. In 2014 Society of Biological Psychiatry Meeting, New York, NY. May 8-10, 2014.

Widge AS, Zorowitz S, Miller EK, Deckersbach T, Dougherty DD. Increased cognitive flexibility as a potential mechanism of ventral capsule/ventral striatum deep brain stimulation: a combined behavior/EEG pilot study. In 2014 American College of Neuropsychopharmacology Meeting, Phoenix, AZ. Dec 6-11, 2014.

Widge AS, Zorowitz SE, Tang W, Miller EK, Deckersbach T, Dougherty DD. Behavioral and neural biomarkers of improved top-down control mediate clinical response to ventral capsule/ventral striatum deep brain stimulation in major depression. In 2015 Society of Biological Psychiatry Meeting, Toronto, Canada. May 14-16, 2015.

15 Widge – Curriculum Vitae

Widge AS, Zorowitz SE, Franklin R, Corse AK, Tang W, Miller EK, Eskandar EN, Deckersbach T, Dougherty DD. Changes in mental flexibility and fronto-cingulate function mediate antidepressant response to ventral capsule/ventral striatum deep brain stimulation. In 2015 Society for Neuroscience Meeting, Chicago, IL, October 17-21, 2015.

Nossenson N, Vallejo Lopez DI, Ellard KK, Paulk AC, Eskandar EN, Deckersbach T, Widge AS, Dougherty DD, Cash SS. Physiological correlates of an emotional conflict resolution task obtained from intracranial recordings in humans. In 2015 Society for Neuroscience Meeting, Chicago, IL, October 17-21, 2015.

Vallejo Lopez DI, Nossenson N, Paulk AC, Ellard KK, Zorowitz SE, Deckersbach T, Eskandar EN, Widge AS, Dougherty DD, Cash SS. Understanding the dynamics of decision making through the multi-source interference task. In 2015 Society for Neuroscience Meeting, Chicago, IL, October 17-21, 2015.

Cheng JJ, Paulk AC, Martinez-Rubio C, McDonald EJ, Patel SR, Widge AS, Eskandar EN. Modulating fear via deep brain stimulation in non-human primates. In 2015 Society for Neuroscience Meeting, Chicago, IL, October 17-21, 2015.

Basu I, Kramer M, Vallejo Lopez DI, Nossenson N, Widge AS, Eskandar EN. Modeling the effects of electrical stimulation on cortical and deep brain local field potentials: potential use in closed loop brain stimulation paradigms. In 2015 Society for Neuroscience Meeting, Chicago, IL, October 17-21, 2015.

16 Widge – Curriculum Vitae

Narrative Report Introduction I am a dually trained psychiatrist-engineer, using my combined training to create new tools for engineering the brain and mind. After MD/PhD training between the University of Pittsburgh and Carnegie Mellon, I completed residency at the University of Washington, then joined MGH/HMS as a Research Fellow and shortly after as an Instructor. I direct the Translational NeuroEngineering Laboratory in the Division of Neurotherapeutics, where I use animal and human models to develop the next generation of psychiatric treatments. Clinically, I am an interventional psychiatrist, treating a range of refractory mental disorders with neuromodulation.

Area of Excellence: Investigation The heart of my work is development of “closed loop” brain stimulators that sense and respond to patients’ ongoing brain activity. I demonstrated the first working model of a psychiatric closed-loop stimulator, and continue to develop this technology. In 2015, I submitted grants based on this work to the DoD Medical Research Program, NIH, and Burroughs Wellcome Fund. I have received seed funding from the Brain & Behavior Research Foundation, MGH-MIT Strategic Partnership, and Harvard Brain Initiative. My intent is to develop a program that “rapidly prototypes” new ideas and technologies in rodents, then uses my Division’s infrastructure to translate discoveries to humans. I am also working on "reverse translation" projects, where we hope to identify putative human biomarkers of DBS response, then use animal models to test closed-loop stimulation based on those responses. Much of this work touches our $30M TRANSFORM DBS program, a BRAIN Initiative grant to develop new human neurostimulation devices and algorithms. I am a member of the leadership team for that program, and co- supervise a team of three postdocs and five research assistants in data analysis. My efforts focus around computational modeling of behavior, closed-loop algorithm development, and design/conduct of human brain stimulation experiments in non-psychiatric patients.

Teaching I am active along two themes: educating clinical audiences about the techniques emerging in our Division, and mentoring junior HMS trainees. In mentoring, I spend time each week with undergraduates, medical students, and postdocs in my and my collaborators' labs. I teach both research techniques and professional skills. In the clinical arena, I have taught regionally and nationally on topics ranging from biomedical engineering to surgical interventions. I am engaged with our HST program, have presented at the HST Faculty Poster Day, and hope to define a neural engineering component within that program.

Supporting Activity: Administrative and Institutional Service My main Supporting Activity is professional service, particularly at the national level in the AMA and APA. I have served on multiple boards and councils, from legislation to long-range strategic planning. This has led to publications on advocacy and academic governance topics, credit on major guidelines, and national leadership awards.

Summary During my time as an Instructor, I have pursued excellence in scholarship, teaching, and leadership. I have obtained resources for research independence and have carved out an integrative niche between multiple mentors and disciplines. I have established myself as a mentor for several junior trainees, some of whom have successfully progressed to their next training phase. I have been invited to present discoveries and progress in my field both regionally and nationally, and my work has been recognized with early-stage awards from private foundations and professional societies. My clinical activities are aligned to my research and support human trials of my ideas. 17