Publications for Patrick Tam

2021 Kim, H., Tam, P., Yang, P. (2021). Defining cell identity 2019 beyond the premise of differential expression. Cell Regeneration, 10(1), 20-3 pages. [More Peng, G., Salehin, N., Knowles, H., Han, J., Fossat, N., Tam, P., Information] et al (2019). Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells. Development, 146(7), Rossant, J., Tam, P. (2021). Opportunities and challenges with 1-14. [More -based models. Stem Cell Reports, 16(5), 1031- Information] 1038. [More Gao, X., Nowak-Imialek, M., Chen, X., Chen, D., Herrmann, Information] D., Ruan, D., Chen, A., Eckersley-Maslin, M., Ahmad, S., Lee, Y., Tam, P., et al (2019). Establishment of porcine and human Fan, X., Masamsetti, V., Sun, J., Engholm-Keller, K., Osteil, P., expanded potential stem cells. Nature Cell Biology, 21(6), 687- Studdert, J., Graham, M., Fossat, N., Tam, P. (2021). TWIST1 699. interact to guide neural crest 2">[More Information] cell differentiation. eLife, 10, e62873. [More Sibbritt, T., Osteil, P., Fan, X., Sun, J., Salehin, N., Knowles, Information] H., Shen, J., Tam, P. (2019). Gene Editing of Mouse Embryonic and Epiblast Stem Cells. In Ivan Bertoncello (Eds.), Mouse 2020 Cell Culture: Methods and Protocols, (pp. 77-95). New York: Springer. [More Information] Liu, Z., Chen, G., Qian, Y., Tam, P., et al (2020). Author Correction: Molecular architecture of lineage allocation and McMahon, R., Sibbritt, T., Salehin, N., Osteil, P., Tam, P. tissue organization in early mouse embryo. Nature, 577(7791), (2019). Mechanistic insights from the LHX1-driven molecular E6. [More Information] and Differentiation, 61(5), 327-336. [More Tam, P., Ho, J. (2020). Cellular diversity and lineage trajectory: Information] insights from mouse single cell transcriptomes. Development, 147(2), dev179788. [More embryo. Science, 366(6467), 798-799. href="http://dx.doi.org/10.1126/science.aaz6976">[More Information] Shim, W., Sinniah, E., Xu, J., Vitrinel, B., Alexanian, M., Andreoletti, G., Shen, S., Sun, Y., Balderson, B., Boix, C., Peng, G., Suo, S., Cui, G., Yu, F., Wang, R., Chen, J., Chen, S., Tam, P., et al (2020). Conserved Epigenetic Regulatory Logic Liu, Z., Chen, G., Qian, Y., Tam, P., et al (2019). Molecular Infers Governing Cell Identity. Cell Systems, 11(6), 625- architecture of lineage allocation and tissue organization in 639.e13. [More href="http://dx.doi.org/10.1038/s41586-019-1469-8">[More Information] Information] Hamada, H., Tam, P. (2020). Diversity of left-right symmetry Cheng, S., Pei, Y., He, L., Peng, G., Reinius, B., Tam, P., Jing, breaking strategy in animals. F1000Research, 9, 123. [Mor Heterogeneity of Pluripotency Transition and X e Information] Dynamics during Early Mouse Development. Cell Reports, 26(10), 2593-2607.e3. [More network from ATAC-SEQ data. Journal of Bioinformatics and Information] Computational Biology, 18(1), 2040003. [More Humphreys, D., Fossat, N., Demuth, M., Tam, P., Ho, J. (2019). Information] Ularcirc: visualization and enhanced analysis of circular RNAs via back and canonical forward splicing. Nucleic Acids Kim, H., Osteil, P., Humphrey, S., Cinghu, S., Oldfield, A., Research, 47(20), 1-17. [More Yang, P. (2020). Transcriptional network dynamics during the Information] progression of pluripotency revealed by integrative statistical learning. Nucleic Acids Research, 48(4), 1828-1842. [More Information] Sibbritt, T., Ip, C., Khoo, P., Wilkie, E., Jones, V., Sun, J., Shen, J., Peng, G., Han, J., Jing, N., Osteil, P., Tam, P., Fossat, Fan, X., Waardenberg, A., Demuth, M., Osteil, P., Sun, J., N., et al (2018). A gene regulatory network anchored by LIM Loebel, D., Graham, M., Tam, P., Fossat, N. (2020). Twist1 homeobox 1 for embryonic head development. Genesis, 56(9), homodimers and heterodimers orchestrate lineage-specific 1-13. [More differentiation. Molecular and Cellular Biology, 40(11). href="http://dx.doi.org/10.1128/MCB.00663-19">[More Information] Rossant, J., Tam, P. (2018). Exploring early human embryo development. Science, 360(6393), 1075-1076. [More href="http://dx.doi.org/10.1016/j.stem.2016.12.004">[More Information] Information] McDonald, M., Morse, A., Schindeler, A., Mikulec, K., Zamir, L., Singh, R., Nathan, E., Patrick, R., Yifa, O., Yahalom- Peacock, L., Cheng, T., Bobyn, J., Lee, L., Baldock, P., Ronen, Y., Arraf, A., Schultheiss, T., Suo, S., Han, J., Tam, P., Croucher, P., Tam, P., Little, D. (2018). Homozygous Dkk1 et al (2017). Nkx2.5 marks angioblasts that contribute to Knockout Mice Exhibit High Bone Mass Phenotype Due to hemogenic endothelium of the endocardium and dorsal aorta. Increased Bone Formation. Calcified Tissue International, eLife, 6, 1-31. [More 017-0338-4">[More Information] Information] Cui, G., Suo, S., Wang, R., Qian, Y., Han, J., Peng, G., Tam, P., Savatier, P., Osteil, P., Tam, P. (2017). Pluripotency of embryo- Jing, N. (2018). Mouse gastrulation: Attributes of transcription derived stem cells from rodents, lagomorphs, and primates: factor regulatory network for epiblast patterning. Development, Slippery slope, terrace and cliff. Stem Cell Research, 19, 104- Growth and Differentiation, 60(8), 463-472. [More href="http://dx.doi.org/10.1016/j.scr.2017.01.008">[More Information] Information] Yu, Z., Tang, P., Wang, J., Bao, S., Shieh, J., Leung, A., Zhang, Chiang, I., Fritzsche, M., Thievend, C., Neal, A., Holmes, K., Z., Gao, F., Wong, S., Hui, A., Tam, P. (2018). Mutations in Lagendijk, A., Overman, J., D'Angelo, D., Omini, A., Tam, P. Hnrnpa1 cause congenital heart defects. JCI Insight, 3(2), 1-21. (2017). SoxF factors induce Notch1 expression via direct [More transcriptional regulation during early arterial development. Information] Development, 144(20), 3847-3848. [More Friedman, C., Nguyen, Q., Lukowski, S., Helfer, A., Chiu, H., Information] Miklas, J., Levy, S., Suo, S., Han, J., Osteil, P., Tam, P., et al (2018). Single-Cell Transcriptomic Analysis of Cardiac Chen, J., Suo, S., Tam, P., Han, J., Peng, G., Jing, N. (2017). Differentiation from Human PSCs Reveals HOPX-Dependent Spatial transcriptomic analysis of cryosectioned tissue samples Cardiomyocyte Maturation. Cell Stem Cell, 23(4), 586-598. [More href="http://dx.doi.org/10.1038/nprot.2017.003">[More Information] Information] Liu, C., Wang, R., He, Z., Osteil, P., Wilkie, E., Yang, X., 2016 Chen, J., Cui, G., Guo, W., Chen, Y., Tam, P., et al (2018). Suppressing Nodal Signaling Activity Predisposes Ectodermal Zheng, G., Zhang, J., Zhao, H., Wang, H., Pang, M., Qiao, X., Differentiation of Epiblast Stem Cells. Stem Cell Reports, Lee, S., Hsu, T., Tan, T., Lyons, J., Zhao, Y., Loebel, D., Wang, 11(1), 43-57. [More Harris, D., et al (2016). a3 Integrin of Cell-Cell Contact Information] Mediates Kidney Fibrosis by Integrin-Linked Kinase in Proximal Tubular E-Cadherin Deficient Mice. American 2017 Journal of Pathology, 186(7), 1847-1860. [More Yang, J., Ryan, D., Wang, W., Tsang, J., Lan, G., Masaki, H., Information] Gao, X., Antunes, L., Yu, Y., Tam, P., et al (2017). Establishment of mouse expanded potential stem cells. Nature, Kondo, M., Gray, L., Pelka, G., Leang, S., Christodoulou, J., 550(7676), 393-397. [More model of Rett syndrome: Therapeutic effects of environmental Information] stimulation and physical activity. Developmental Neurobiology, 76(2), 209-224. [More Amaya, A., Zhu, E., Khandekar, N., Ginn, S., Liao, S., Information] Cunningham, S., Sasaki, N., Cabanes-Creus, M., Tam, P., Lisowski, L., Alexander, I., et al (2017). Identification of liver- Fossat, N., Radziewic, T., Jones, V., Tourle, K., Tam, P. (2016). specific enhancer-promoter activity in the 3' untranslated region Conditional restoration and inactivation of Rbm47 reveal its of the wild-type AAV2 genome. Nature Genetics, 49(8), 1267- tissue-context requirement for viability and growth. Genesis, 1273. [More 54(3), 115-122. href="http://dx.doi.org/10.1002/dvg.22920">[More Information] Fatima, S., Wagstaff, K., Lieu, K., Davies, R., Tanaka, S., Yamaguchi, Y., Loveland, K., Tam, P., Jans, D. (2017). Bildsoe, H., Fan, X., Wilkie, E., Ashoti, A., Jones, V., Power, Interactome of the inhibitory isoform of the nuclear transporter M., Qin, J., Wang, J., Tam, P., Loebel, D. (2016). Dataset of Importin 13. Biochimica et Biophysica Acta, 1864 (3), 546-561. TWIST1-regulated genes in the cranial mesoderm and a [More neural crest. Data in Brief, 9, 372-375. href="http://dx.doi.org/10.1016/j.dib.2016.09.001">[More Information] Peng, G., Tam, P., Jing, N. (2017). Lineage specification of early and embryonic stem cells at the dawn of Tam, P., Fossat, N., Wilkie, E., Loebel, D., Ip, C., Ramialison, enabling technologies. National Science Review, 4(4), 533-542. M. (2016). Formation of the Embryonic Head in the Mouse: [More Attributes of a Gene Regulatory Network. Current Topics in Information] , 117, 497-521. [More Rossant, J., Tam, P. (2017). New insights into early human Information] development: lessons for stem cell derivation and Osteil, P., Studdert, J., Wilkie, E., Fossat, N., Tam, P. (2016). 2014 Generation of genome-edited mouse epiblast stem cells via a Tanaka, S., Yamaguchi, Y., Jones, V., Tam, P. (2014). detour through ES cell-chimeras. Differentiation, 91(45), 119- Analyzing gene function in whole mouse embryo and fetal 125. [More Embryology: Methods and Protocols, (pp. 367-393). New Information] York: Humana Press. [More Information] implantation Mouse Embryos. Cell Stem Cell, 18(1), 3-4. [More Studdert, J., Power, M., Jones, V., Loebel, D., Tam, P. (2014). Information] C to U RNA editing mediated by APOBEC1 requires RNA- Peng, G., Suo, S., Chen, J., Chen, W., Liu, C., Yu, F., Wang, binding RBM47. EMBO Reports, 15(8), 903-910. [More Transcriptome for the Molecular Annotation of Lineage Fates Information] and Cell Identity in Mid-gastrula Mouse Embryo. Kaufman-Francis, K., Goh, H., Kojima, Y., Studdert, J., Jones, Developmental Cell, 36(6), 681-697. [More (2014). Differential response of epiblast stem cells to Nodal and Information] Activin signalling: A paradigm of early endoderm development Loebel, D., Plageman, T., Tang, T., Jones, V., Muccioli, M., in the embryo. Philosophical Transactions of the Royal Society Tam, P. (2016). Thyroid bud morphogenesis requires CDC42- B, 369(1657), 1-10. [More 5(2), 130-139. href="http://dx.doi.org/10.1242/bio.014415">[More Loebel, D., Radziewic, T., Power, M., Studdert, J., Tam, P. Information] (2014). Generation of mouse embryos with small hairpin RNA- Bildsoe, H., Fan, X., Wilkie, E., Ashoti, A., Jones, V., Power, mediated knockdown of gene expression. In Mark Lewandoski M., Qin, J., Wang, J., Tam, P., Loebel, D. (2016). (Eds.), Mouse Molecular Embryology: Methods and Protocols, Transcriptional targets of TWIST1 in the cranial mesoderm (pp. 119-142). New York: Humana Press. [More Developmental Biology, 418(1), 189-203. href="http://dx.doi.org/10.1016/j.ydbio.2016.08.016">[More Ip, C., Fossat, N., Jones, V., Lamonerie, T., Tam, P. (2014). Information] Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the 2015 anterior mesendoderm. Development, 141(20), 3859-3867. [More McShane, S., Mole, M., Savery, D., Greene, N., Tam, P., Copp, Information] A. (2015). Cellular basis of neuroepithelial bending during Hamada, H., Tam, P. (2014). Mechanisms of left-right mouse spinal neural tube closure. Developmental Biology, asymmetry and patterning: driver, mediator and responder. 404(2), 113-124. [More href="http://dx.doi.org/10.12703/P6-110">[More Information] Information] Fossat, N., Ip, C., Jones, V., Studdert, J., Khoo, P., Lewis, S., Gold, W., Williamson, S., Kaur, S., Hargreaves, I., Land, J., Power, M., Tourle, K., Loebel, D., Kwan, K., Tam, P., et al Pelka, G., Tam, P., Christodoulou, J. (2014). Mitochondrial (2015). Context-specific function of the LIM homeobox 1 dysfunction in the skeletal muscle of a mouse model of Rett transcription factor in head formation of the mouse embryo. syndrome (RTT): Implications for the disease phenotype. Development, 142(11), 2069-2079. [More href="http://dx.doi.org/10.1016/j.mito.2014.02.012">[More Information] Information] Williamson, S., Ellaway, C., Peters, G., Pelka, G., Tam, P., Fossat, N., Tam, P. (2014). Re-editing the paradigm of Cytidine Christodoulou, J. (2015). Deletion of protein tyrosine (C) to Uridine (U) RNA editing. RNA Biology, 11(10), 1233- phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett 1237. [More Genetics, 23(9), 1171-1175. href="http://dx.doi.org/10.1038/ejhg.2014.249">[More Information] Kojima, Y., Kaufman-Francis, K., Studdert, J., Steiner, K., Power, M., Loebel, D., Jones, V., Hor, A., de Alencastro, G., Greenlees, R., Mihelec, M., Yousoof, S., Speidel, D., Wu, S., Logan, G., Alexander, I., Pickett, H., Tam, P., et al (2014). The Rinkwitz, S., Prokudin, I., Perveen, R., Cheng, A., Ma, A., Transcriptional and Functional Properties of Mouse Epiblast Nash, B., Loebel, D., Grigg, J., Tam, P., Becker, T., Jamieson, Stem Cells Resemble the Anterior Primitive Streak. Cell Stem R., et al (2015). Mutations in SIPA1L3 cause eye defects Cell, 14(1), 107-120. [More organization. Human Molecular Genetics, 24(20), 5789-5804. Information] [More Information] Loebel, D., Hor, A., Bildsoe, H., Tam, P. (2014). Timed Deletion of Twist1 in the Limb Bud Reveals Age-Specific Pera, M., de Wert, G., Dondorp, W., Lovell-Badge, R., Impacts on Autopod and Zeugopod Patterning. PloS One, 9(6), Mummery, C., Munsie, M., Tam, P. (2015). What if stem cells 1-9. [More [More Information] Information] Kojima, Y., Tam, O., Tam, P. (2014). Timing of developmental events in the early mouse embryo. Seminars in Cell & Williamson, S., Giudici, L., Kilstrup-Nielsen, C., Gold, W., Developmental Biology, 34, 65-75. [More Christodoulou, J. (2012). A novel transcript of cyclin-dependent Information] kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain. Human Genetics, 131(2), 187- 2013 200. [More Information] Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013). Alternative lengthening of telomeres in Arkell, R., Tam, P. (2012). Initiating head development in normal mammalian somatic cells. Genes and Development, mouse embryos: integrating signalling and transcriptional 27(1), 18-23. [More href="http://dx.doi.org/10.1098/rsob.120030">[More Information] Information] Maxwell, S., Pelka, G., Tam, P., El-Osta, A. (2013). Chromatin Stephenson, R., Rossant, J., Tam, P. (2012). Intercellular context and ncRNA highlight targets of MeCP2 in brain. RNA interactions, position, and polarity in establishing blastocyst cell Biology, 10(11), 1741-1757. [More in Biology, 4(11), 1-15. href="http://dx.doi.org/10.1101/cshperspect.a008235">[More Information] Tanaka, S., Nakane, A., Yamaguchi, Y., Terabayashi, T., Abe, T., Nakao, K., Asashima, M., Steiner, K., Tam, P., Fossat, N., Jones, V., Garcia-Garcia, M., Tam, P. (2012). Nishinakamura, R. (2013). Dullard/Ctdnep1 Modulates WNT Modulation of WNT signaling activity is key to the formation Signalling Activity for the Formation of Primordial Germ Cells of the embryonic head. Cell Cycle, 11(1), 26-32. [More href="http://dx.doi.org/10.1371/journal.pone.0057428">[More Information] Information] Loebel, D., Hor, A., Bildsoe, H., Jones, V., Chen, Y., Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Behringer, R., Tam, P. (2012). Regionalized Twist1 activity in Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., the forelimb bud drives the morphogenesis of the proximal and Fraser, S., Tam, P., et al (2013). Generation of mice deficient in preaxial skeleton. Developmental Biology, 362(2), 132-140. [More role for these factors in embryonic globin gene silencing. Information] Molecular and Cellular Biology, 33(15), 2976-2987. [More development and differentiation. Small GTPases, 3(1), 40-44. Information] [More Tam, P., Nelson, W., Rossant, J. (2013). Mammalian Information] Development: Networks, Switches, and Morphogenetic Processes. New York: Cold Spring Harbor Laboratory Press. 2011 Stephenson, R., Rossant, J., Tam, P. (2013). Reprint: Tam, P. (2011), Endoderm Formation: Not So Black and White Intercellular Interactions, Position, and Polarity in Establishing Anymore. [More Networks, Switches, and Morphogenetic Processes, (pp. 167- Information] 182). New York: Cold Spring Harbor Laboratory Press. Coombes, A., Bowles, J., Feng, C., Chiu, H., Khoo, P., Jackson, Tam, P., Pera, M. (2013). Stem cell science and regenerative A., Little, M., Tam, P., Koopman, P. (2011). Expression and medicine. BioEssays, 35(3), 147-148. [More Sexual Development, 5(3), 124-130. href="http://dx.doi.org/10.1159/000327709">[More Information] Bildsoe, H., Loebel, D., Jones, V., Hor, A., Braithwaite, A., Chen, Y., Behringer, R., Tam, P. (2013). The mesenchymal Tanaka, S., Kojima, Y., Yamaguchi, Y., Nishinakamura, R., architecture of the cranial mesoderm of mouse embryos is Tam, P. (2011). Impact of WNT signaling on tissue lineage disrupted by the loss fof Twist1 function. Developmental differentiation in the early mouse embryo. Development, Biology, 374(2), 295-307. [More href="http://dx.doi.org/10.1111/j.1440- Information] 169X.2011.01292.x">[More Information] Ng, H., Tam, P. (2013). The mystique of cellular Fossat, N., Loebel, D., Jones, V., Khoo, P., Bildsoe, H., Tam, P. reprogramming. Current Opinion in Genetics & Development, (2011). Marking Cells for Imaging Analysis of Morphogenetic 23(5), 501-503. [More Rachel Wong (Eds.), Imaging in Developmental Biology: A Information] Laboratory Manual, (pp. 311-329). Woodbury, New York, USA: Cold Spring Harbor Laboratory Press. Arkell, R., Fossat, N., Tam, P. (2013). Wnt signalling in mouse gastrulation and anterior development: new players in the Loebel, D., Studdert, J., Power, M., Radziewic, T., Jones, V., pathway and signal output. Current Opinion in Genetics & Coultas, L., Jackson, Y., Rao, R., Steiner, K., Fossat, N., Tam, Development, 23(4), 454-460. [More facilitates differentiation of the foregut endoderm. Information] Development, 138(20), 4511-4522. [More 2012 Information] Pfister, S., Jones, V., Power, M., Truisi, G., Khoo, P., Steiner, Development, 136(5), 701-713. [More Sox17-dependent gene expression and early heart and gut Information] development in Sox17-deficient mouse embryos. International Mihelec, M., Abraham, P., Gibson, K., Krowka, R., Susman, Journal of Developmental Biology, 55(1), 45-58. [More Grigg, J., Jamieson, R., et al (2009). Novel SOX2 partner-factor Information] domain mutation in a four-generation family. European Journal Fossat, N., Jones, V., Khoo, P., Bogani, D., Hardy, A., Steiner, of Human Genetics, 17(11), 1417-1422. [More Tam, P. (2011). Stringent Requirement of a Proper Level of Information] Canonical WNT Signalling Activity for Head Formation in Bildsoe, H., Loebel, D., Jones, V., Chen, Y., Behringer, R., Mouse Embryo. Development, 138(4), 667-676. [More skull vault development in the mouse embryo. Developmental Information] Biology, 331(2), 176-188. [More Information] Harikrishnan, K., Bayles, R., Ciccotosto, G., Maxwell, S., Tam, P., Loebel, D. (2009). Specifying mouse embryonic germ Cappai, R., Pelka, G., Tam, P., Christodoulou, J., El-Osta, A. cells. Cell, 137(3), 398-400. [More Norepinephrine Slc6a2 Transporter Gene in Depolarized Information] Neurons. Journal of Neuroscience, 30(4), 1494-1501. [More Information] B., Whitty, G., Vinson, A., Be, C., Li, S., Tam, P. (2009). Thrombin-cleaved osteopontin regulates hemopoietic stem and Rivera-Perez, J., Jones, V., Tam, P. (2010). Culture of Whole progenitor cell functions through interactions with α9β1 and Mouse Embryos at Early Postimplantation to Organogenesis α4β1 integrins. Blood, 114(1), 49-59. [More Wassarman and Philippe M. Soriano (Eds.), Methods in Information] Enzymology Volume 476: Guide to Techniques in Mouse Development, Part A: Mice, Embryos, and Cells, (pp. 185-203). United States: Elsevier. [More Information] Parameswaran, M., Quinlan, G., Gordon, M., Sturm, K., Tam, P., et al (2008). Application of lacZ Transgenic Mice to Cell Pera, M., Tam, P. (2010). Extrinsic regulation of pluripotent Lineage Studies. Methods in Molecular Biology, 461, 149-164. stem cells. Nature, 465(7299), 713-720. [More 8_10">[More Information] Information] Furtado, M., Solloway, M., Jones, V., Costa, M., Biben, C., Tanaka, S., Yamaguchi, Y., Steiner, K., Nakano, T., Wolstein, O., Preis, J., Sparrow, D., Saga, Y., Dunwoodie, S., et Nishinakamura, R., Kwan, K., Behringer, R., Tam, P. (2010). al (2008). BMP/SMAD1 signaling sets a threshold for the Loss of Lhx1 activity impacts on the localization of primordial left/right pathway in lateral plate mesoderm and limits germ cells in the mouse. Developmental Dynamics, 239(11), availability of SMAD4. Genes and Development, 22, 3037- 2851-2859. [More href="http://dx.doi.org/10.1002/dvdy.22417">[More Information] Information] Quinlan, G., Khoo, P., Wong, N., Trainor, P., Tam, P. (2008). Leung, A., Wong, S., Chan, D., Tam, P., Cheah, K. (2010). Cell grafting and labeling in postimplantation mouse embryos. Loss of Procollagen IIA From the Anterior Mesendoderm Methods in Molecular Biology, 461, 47-70. [More Developmental Dynamics, 239(9), 2319-2329. href="http://dx.doi.org/10.1002/dvdy.22366">[More Information] Mihelec, M., St Heaps, L., Flaherty, M., Billson, F., Rudduck, C., Tam, P., Grigg, J., Peters, G., Jamieson, R. (2008). Fath, T., Chan, Y., Vrhovski, B., Clarke, H., Curthoys, N., Chromosomal Rearrangements and Novel Genes in Disorders Hook, J., Lemckert, F., Schevzov, G., Tam, P., Watson, C., of Eye Development, Cataract and Glaucoma. Twin Research Gunning, P., et al (2010). New aspects of tropomyosin- and Human Genetics, 11(4), 412-421. [More and 2. European Journal of Cell Biology, 89(7), 489-498. href="http://dx.doi.org/10.1016/j.ejcb.2009.11.028">[More Information] Lewis, S., Khoo, P., Young, A., Steiner, K., Willcock, C., Mukhopadhyay, M., Westphal, H., Jamieson, R., Robb, L., Weaving, L., Mihelec, M., Storen, R., Sosic, D., Grigg, J., Tam, Tam, P. (2008). Dkk1 and Wnt3 interact to control head P., Jamieson, R. (2010). Twist2: Role in Corneal Stromal morphogenesis in the mouse. Development, 135(10), 1791- Keratocyte Proliferation and Corneal Thickness. Investigative 1801. [More Ophthalmology and Visual Science, 51(11), 5561-5570. href="http://dx.doi.org/10.1167/iovs.09-5123">[More Information] Kondo, M., Gray, L., Pelka, G., Christodoulou, J., Tam, P., Hannan, A. (2008). Environmental enrichment ameliorates a 2009 motor coordination deficit in a mouse model of Rett syndrome - Mecp2 gene dosage effects and BDNF expression. European Rossant, J., Tam, P. (2009). Blastocyst lineage formation, early Journal of Neuroscience, 27(12), 3342-3350. [More Information] Behringer, R., Mukhopadhyay, M., Westphal, H., Tam, P. (2007). Genetic interaction of Gsc and Dkk1 in head Franklin, V., Khoo, P., Bildsoe, H., Wong, N., Lewis, S., Tam, morphogenesis of the mouse. Mechanisms of Development, P. (2008). Regionalisation of the endoderm progenitors and 124(2), 157-165. [More Mechanisms of Development, 125(7), 587-600. href="http://dx.doi.org/10.1016/j.mod.2008.04.001">[More Information] Tam, P., Khoo, P., Lewis, S., Bildsoe, H., Wong, N., Tsang, T., Gad, J., Robb, L. (2007). Sequential allocation and global 2007 pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Development, 134(2), 251-260. [More landscape of mouse embryogenesis. Developmental Cell, 13(6), Information] 761-762. [More 2006 Information] Tam, P., Loebel, D., Tanaka, S. (2006). Building the mouse Tam, P., Lovell-Badge, R. (2007). Anne McLaren 1927-2007. gastrula: signals, asymmetry and lineages. Current Opinion In Cell, 130(2), 201-213. [More eve&db=pubmed&dopt=Abstract&list_uids=17712928">[More Information] Information] Willcock, C., Grigg, J., Wilson, M., Tam, P., Billson, F., Jamieson, R., Farrar, N., Stewart, K., Perveen, R., Mihelec, M., Jamieson, R. (2006). Congenital iris ectropion as an indicator of Carette, M., Grigg, J., McAvoy, J., Lovicu, F., Tam, P., et al variant aniridia. British Journal of Ophthalmology, 90(5), 658- (2007). Characterization of a familial t(16;22) balanced 659. [More identification of a novel gene, TMEM114, expressed in the lens Information] and disrupted by the translocation. Human Mutation, 28(10), 968-977. [More embryo: Formation, cell fates, and morphogenetic function. Information] Developmental Dynamics, 235(9), 2315-2329. [More Tanaka, S., Yamaguchi, Y., Tam, P. (2007). Experimental Information] approaches to study gene function in whole mouse embryo and fetal ovary in vitro. 7th Transgenic Technology (TT) Meeting Nolen, L., Amor, D., Haywood, A., St. Heaps, L., Willcock, C., (TT2007), Netherlands: Springer-Verlag. Mihelec, M., Tam, P., Billson, F., Grigg, J., Peters, G., Jamieson, R. (2006). Deletion at 14q22-23 indicates a Franklin, V., Bildsoe, H., Tam, P. (2007). Fate-Mapping contiguous gene syndrome comprising anophthalmia, pituitary Technique: Grafting Fluorescent Cells into Gastrula-Stage hypoplasia, and ear anomalies. American Journal of Medical Mouse Embryos at 7-7.5 Days Post-coitum. CSH protocols, Genetics, Part A, 140(16), 1711-1718. [More href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retri Information] eve&db=pubmed&dopt=Abstract&list_uids=21356983">[More Information] Duffy, S., Steiner, K., Tam, P., Boyd, A. (2006). Expression analysis of the Epha1 receptor tyrosine kinase and its high- Khoo, P., Franklin, V., Tam, P. (2007). Fate-Mapping affinity ligands Efna1 and Efna3 during early mouse Technique: Targeted Whole-Embryo Electroporation of DNA development. Gene Expression Patterns, 6(7), 719-723. [More Post-coitum. CSH protocols, 2007, 4893. href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retri eve&db=pubmed&dopt=Abstract&list_uids=21356984">[More Yamaguchi, Y., Tanaka, S., Kasa, M., Yasuda, K., Tam, P., Information] Matsui, Y. (2006). Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells. Bildsoe, H., Franklin, V., Tam, P. (2007). Fate-mapping Gene Expression Patterns, 6(6), 607-612. [More gastrula-stage mouse embryos cultured in vitro. CSH protocols, Information] 2007, 4915. [More H., Christodoulou, J., Tam, P. (2006). Mecp2 deficiency is Information] associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain, 129(Pt 4), Pfister, S., Steiner, K., Tam, P. (2007). Gene expression pattern 887-898. [More implantation period of mouse development. Gene Expression Information] Patterns, 7(5), 558-573. [More Yamaguchi, Y., Tanaka, S., Yasuda, K., Matsui, Y., Tam, P. Information] (2006). Stage-specific Importin13 activity influences meiosis of germ cells in the mouse. Developmental Biology, 297(2), 350- Tam, P., Loebel, D. (2007). Gene function in mouse 360. [More Genetics, 8(5), 368-381. href="http://dx.doi.org/10.1038/nrg2084">[More Information] 2005 Endoderm Of The Mouse Gastrula And The Impact Of Loss Of Loebel, D., Tsoi, B., Wong, N., Tam, P. (2005). A conserved Lhx1(Lim1) Function. Developmental Biology, 274(1), 171- noncoding intronic transcript at the mouse Dnm3 locus. 187. [More href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retri Information] eve&db=pubmed&dopt=Abstract&list_uids=15885504">[More Tanaka, S., Nagamatsu, G., Tokitake, Y., Kasa, M., Tam, P., Information] Matsui, Y. (2004). Regulation Of Expression Of Mouse Loebel, D., Tam, P. (2005). A gut feeling. Nature Interferon-Induced Transmembrane Protein Like Gene-3, Ifitm3 Biotechnology, 23(12), 1491-1492. [More 230(4), 651-659. href="http://dx.doi.org/10.1002/dvdy.20085">[More Information] Pelka, G., Watson, C., Christodoulou, J., Tam, P. (2005). Distinct expression profiles of Mecp2 transcripts with different Ding, H., Schertzer, M., Wu, X., Gertsenstein, M., Selig, S., lengths of 3'UTR in the brain and visceral organs during mouse Kammori, M., Pourvali, R., Poon, S., Vulto, I., et al, Tam, P. development. Genomics, 85(4), 441-452. [More Essential Gene Encoding A Helicase-Like Protein. Cell, 117(7), Information] 873-886. [More Tanaka, S., Yamaguchi, Y., Tsoi, B., Lickert, H., Tam, P. Information] (2005). IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and Loebel, D., Tsoi, B., Wong, N., O'Rourke, M., Tam, P. (2004). repulsion. Developmental Cell, 9(6), 745-756. [More Implantation Mouse Development. Gene Expression Patterns, Information] 4(4), 467-471. [More Watson, C., Pelka, G., Radziewic, T., Shahbazian, M., Information] Christodoulou, J., Williamson, S., Tam, P. (2005). Reduced proportion of Purkinje cells expressing 2003 paternally derived mutant Mecp2 308 allele in female mouse cerebellum is not due to a skewed primary pattern of X- Hukriede, N., Tsang, T., Habas, R., Khoo, P., Steiner, K., chromosome inactivation. Human Molecular Genetics, 14(13), Weeks, D., Tam, P., Dawid, I. (2003). Conserved requirement 1851-1861. [More Developmental Cell, 4(1), 83-94. href="http://dx.doi.org/10.1016/S1534-5807(02)00398- 2">[More Information] 2004 Tam, P., Kanai-Azuma, M., Kanai, Y. (2003). Early endoderm Ding, H., Wu, X., Bostrom, H., Kim, I., Wong, N., Tsoi, B., development in vertebrates: lineage differentiation and O'Rourke, M., Koh, G., Soriano, P., Betsholtz, C., Tam, P., et morphogenetic function. Current Opinion In Genetics and al (2004). A Specific Requirement For PDGF-C In Palate Development, 13(4), 393-400. [More Information] href="http://dx.doi.org/10.1038/ng1415">[More Loebel, D., Watson, C., De Young, R., Tam, P. (2003). Lineage Information] choice and differentiation in mouse embryos and embryonic Tam, P. (2004). Embryonic Axes: The Long And Short Of It In stem cells. Developmental Biology, 264(1), 1-14. [More 7">[More Information] Information] Tam, P., Rossant, J. (2003). Mouse embryonic chimeras: tools Rossant, J., Tam, P. (2004). Emerging Asymmetry And for studying mammalian development. Development, 130, 6155- Embryonic Patterning In Early Mouse Development. 6163. [More Developmental Cell, 7(2), 155-164. href="http://dx.doi.org/10.1016/j.devcel.2004.07.012">[More Information] 2002 Robb, L., Tam, P. (2004). Gastrula Organiser And Embryonic Stone, L., Tan, S., Tam, P., Finger, T. (2002). Analysis of Cell Patterning In The Mouse. Seminars in Cell and Developmental Lineage Relationships in Taste Buds. Journal of Neuroscience, Biology, 15(5), 543-554. [More href="http://dx.doi.org/10.1523/jneurosci.22-11- Information] 04522.2002">[More Information] Weaving, L., Christodoulou, J., Williamson, S., Friend, K., Kanai-Azuma, M., Kanai, Y., Gad, J., Tajima, Y., Taya, C., McKenzie, O., Archer, H., Evans, J., Clarke, A., Pelka, G., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P., Tam, P., Lahooti, H., Ellaway, C., Bennetts, B., Watson, C., et et al (2002). Depletion of definitive gut endoderm in Sox17-null al (2004). Mutations Of Cdkl5 Cause A Severe mutant mice. Development, 129(10), 2367-2379. Neurodevelopmental Disorder With Infantile Spasms And Ristevski, S., Tam, P., Hertzog, P., Kola, I. (2002). Ets2 is Mental Retardation. American Journal of Human Genetics, 75, expressed during morphogenesis of the somite and limb in the 1079-1093. [More mouse embryo. Mechanisms of Development, 116, 165-168. href="http://dx.doi.org/10.1016/S0925-4773(02)00126- Tam, P., Khoo, P., Wong, N., Tsang, T., Behringer, R. (2004). 0">[More Information] Regionalization Of Cell Fates And Cell Movement In The Tam, P. (2002). First mitotic division: getting it right at the start. Nature Cell Biology, 4(10), E232-E232. href="http://dx.doi.org/10.1038/ncb1002-e232">[More Tam, P., Kinder, S., Tsang, T., Gad, J., Behringer, R. (2001). Information] Morphogenetic tissue movement and the establishment of body Loebel, D., O'Rourke, M., Steiner, K., Banyer, J., Tam, P. plan during development from blastocyst to gastrula in the (2002). Isolation of Differentially Expressed Genes from Wild- mouse. BioEssays, 23, 508-517. Type and Twist Mutant Mouse Limb Buds. Genesis, 33(3), 103- Tsang, T., Tam, P., Khoo,, P., Jamieson, R., Zhou,, S., Ang,, S., 113. [More Behringer, R. (2001). The allocation and differentiation of Information] mouse primordial germ cells. International Journal of Hart, A., Hartley, L., Sourris, K., Stadler, E., Li, R., Stanley, E., Developmental Biology, 45, 549-555. Tam, P., Elefanty, A., Robb, L. (2002). Mixl1 is required for Kinder, S., Tsang, T., Tam, P., Wakamiya, M., Sasaki, H., axial mesendoderm morpogenesis and patterning in the murine Behringer, R., Nagy,, A. (2001). The organizer of the mouse embryo. Development, 129(15), 3597-3608. gastrula is composed of a dynamic population of progenitor Tam, P., Rossant, J. (2002). Mouse Development: Patterning, cells for the axial mesoderm. Development, 128, 3623-3634. Morphogenesis and Organogensis. San Francisco United States: Academic Press. Tam, P., Gossler, A. (2002). Somitogenesis: Segmentation of the Paraxial Mesodeerm and the delineation of tissue compartments. In Janet Rossant & Patrick L. Tam (Eds.), Mouse Development, (pp. 127-149). San Francisco: Staempfli Publishers Ltd. Soo, K., O'Rourke, M., Khoo, P., Steiner, K., Wong, N., Behringer, R., Tam, P. (2002). Twist Function is Required for morphogenesis of the Cephalic Neural Tuve and the Differentiation of the Cranial Neura Crest Cells in the Mouse Embryo. Developmental Biology, 247(2), 251-270. [More Information] O'Rourke, M., Tam, P. (2002). Twist Functions in mouse development. International Journal of Developmental Biology, 46(4), 401-413. O'Rourke, M., Soo, K., Behringer, R., Hui, C., Tam, P. (2002). Twist plays an essential role in FGF and SHH Signal Transduction during Mouse Limb Development. Developmental Biology, 248(1), 143-156. [More Information] 2001 Kinder, S., Tam, P., Loebel, D. (2001). Allocation and Early Differentiation of Cardiovascular Progenitors in the Mouse Embryo. Trends In Cardiovascular Medicine, 11, 177-183. Tam, P., Hadjantonakis, A., Cox,, L., Nagy,, A. (2001). An X- linked GFP transgene reveals unexpected paternal X- Chromosome activity in trophoblastic Giant Cells of the Mouse Placenta. Genesis, 29, 133-140. Tam, P., Watson,, C. (2001). Cell Lineage Determination in the Mouse. Cell Structure and Function, 26, 123-129. Kinder, S., Tsang, T., Tam, P., Ang,, S., Behringer, R. (2001). Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3B activity. International Journal of Developmental Biology, 45, 347-355. Tam, P., Ristevski, S., Kola,, I., Hertzog, P. (2001). Desrt, an AT-rich interaction domain family transcription factor gene, is an early marker for nephrogenic mesoderm and is expressed dynamically during mourse limb development. Mechanisms of Development, 104, 139-142. Tam, P., So, C., Cheah, K. (2001). Impact of mutations of cartilage matrix genes on matrix structure, gene activity and chondrogenesis. Osteoarthritis and Cartilage, 9. Orford, J., Manglick, P., Cass, D., Tam, P. (2001). Mechanisms for the development of esophageal atresia. Journal of Pediatric Surgery, 36(7), 985-994. [More