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TOPIM 2014 Conference Book IMAGING THE DEVELOPMENT HOT TOPIC IN MOLECULAR IMAGING – TOPIM 2014 THE „ECOLE DE PHYSIQUE DES HOUCHES“, FRANCE – MAP 2 venue IMAGING THE DEVELOPMENT THE „ECOLE DE PHYSIQUE DES HOUCHES“, FRANCE ...is a resort village in the Chamonix valley in the French Alps. Established in 1951, the Physics School is located in a group of chalets surrounded by meadows and woods, at an altitude of 1150 m facing the Mont-Blanc range - a very favourable environment for intel- lectual activity in ideal surroundings for skiing, hiking or mountaineering. The Mont Blanc is the highest mountain in the Alps, West- ern Europe and the European Union. It rises 4,810.45 m above sea level and is ranked 11th in the world in topographic prominence. Ecole de Physique des Houches La Côte des Chavants 74310 Les Houches, France +33 (0)4 50 54 40 69 HOW TO GET TO LES HOUCHES By plane: Geneva Airport is 1 hour drive from Les Houches. The simplest way is to use a shuttle service (approximately 25€ up to the school, book at least three days in advance). Please find here an overview of the different providers: www.chamonix.net/english/transport/transfers.htm There is also a regular bus service between Geneva and Les Houches (max. twice a day). You should then take a taxi for the last 5 km from the Les Houches village to the school. You can also travel from Geneva to Les Houches by train (+ taxi from the train station to the School), but it is rather complicated and long (go through Annemasse on the French side or through Martigny on the Swiss side). By train: arrival at the Les Houches station, with one change at Saint-Gervais (from France), or at Martigny (from Switzerland). There are about 10 trains per day between St Gervais and Les Houches. Then we strongly recommend to take a taxi and to pre- reserve by calling one of the following providers: taxi Garny: +33 6 12 35 30 72, taxi Persault : +33 4 50 54 41 09 and taxi Servoz : +33 6 84 66 86 73 to go up to the school ~5km. By car: Les Houches are easily accessible from France (A41 highway), from Switzerland (Martigny and Col des Montets) and from Italy through the Mont Blanc Tunnel. From Geneva and Le Fayet: 8km before Chamonix, 300 m after passing under the tunnel, bear right by the first road out for “Les Houches Bellevue”. When arriving at the cable car station “Bellevue”, turn right and continue upwards (roughly 2 km starting from the teleferic). 500m after the cable car station “Prarion”, turn left and follow small arrows at crossroads. Continue up to the end of Route de la Côte des Chavants. Here you are! From Chamonix: bear right for “Les Houches-Chef-Lieu”, turn right in Les Houches, and go ahead at the cable car station “Bellevue”. Then proceed as above. Winter equipment for the car is recommended (snow chains). Please park your car at the parking place above the Ecole de Physique. 3 AT THE ECOLE DE PHYSIQUE DES HOUCHES Arriving is possible on Sunday January 19, 2014 from 15:00h onwards. Please note that the school is closed before 15:00h. Within the foyer of the main building you will find a plan indicating the allocation of rooms as well as the instructions how to get in the cha- lets. Participants are housed in “chalets” (electricity: AC, 50Hz, 220V). The first joint meal will be the dinner at 19:30h. Breakfast is from 8:00 am to 8:45 am; Lunch: at 12:30h; and Dinner: 19:30h – sharp! It is possible to order a lunch packet the evening before. A respective list can be found at the restaurant. Meals are taken at the school dining room/restaurant. Drinks are not included - aside of coffee and tea. venue HOT TOPIC IN MOLECULAR IMAGING – TOPIM 2014 4 welcome IMAGING THE DEVELOPMENT WELCOME TO TOPIM 2014 – THE 8TH "HOT TOPIC IN MOLECULAR IMAGING" CONFERENCE OF THE ESMI IMAGING There are two main reasons why in vivo imaging is a key to our understanding of development. THE The first one is that morphogenesis leading to the formation of DEVELOPMENT a functional adult is a dynamic process during which the forms and shapes of the organism change continuously over time: these changes are best described by images. by Bertrand Tavitian The second one is that exploring genetic and molecular posi- tional cues that govern morphogenesis requires long term ob- servations that do not interfere with normal development: the least intrusive method for producing serial and dynamic imaging of an organism is modern in vivo imaging. Among all domains of biological science, development is one for which the quality and relevance of observations depend drasti- cally on non destructive methods. The secret life of embryos and fetuses remained terra incognita for scientists. In the last decades the progress of non-invasive imaging has completely changed our view and in situ medical images of de- veloping life are commonplace: On the research front, immense progress in biophysical and molecular methods to image the development has been ob- tained recently. The precision of morphogenetic descriptions has improved constantly thanks to progress in ultrasonic and magnetic resonance imaging and further progress are awaited. Cell lineage studies have moved from destructive autoradio- graphic methods to intravital optical techniques based on ge- netic molecular engineering, allowing mathematical modeling of the trajectories of individual cells. The role of genetic and epi- genetic factors in organogenesis is observed directly in cohorts of laboratory animals, from simple multicellular forms of life to vertebrates and mammals. Multispectral and multimodal imag- ing techniques such as optoacoustics, paramagnetic resonance imaging, and other, acquire simultaneously several molecular/ 5 morphological points of view of the interactions between the development of an organ or an individual and its environment. Progress in Physics for improved imaging methods and in Math- ematics for the modeling of the images are moving the research on of development from the statute of a descriptive science to a predictive, holistic knowledge, a topic which is not neutral with respect to the future of interventional approaches. TOPIM 2014 will cover the state-of-the-art as well as recent progress in the scientific bases for the imaging of development. Thanks to all of you for your contribution! welcome HOT TOPIC IN MOLECULAR IMAGING – TOPIM 2014 TOPIM 2014 programme IMAGING the DEVELOPMENT 19‐24 January 2014 TOPIM 2014 PROGRAMME OVERVIEW time Monday, 20 January Tuesday, 21 January Wednesday, 22 January Thursday, 23 January Friday, 24 January 08:00 - 08:45 breakfast 08:45 - 08:50 Welcome - 08:50 - 08:55 Imaging vessel remodeling at the micro-scale 08:55 - 09:00 Bertrand Tavitian, Paris Essential Genes for Development: Imaging of Adult neurogenesis in physiology and during Imaging vascular remodeling in reproduction and during development: implications for tissue 09:00 - 09:05 Mouse Embryonic Lethals Parkinson's disease development 09:05 - 09:10 engineering and understanding congenital Mark R. Henkelmann - Toronto Jens Schwamborn - Esch-sur-Azette Michal Neeman, Rehovot 09:10 - 09:15 disease 09:15 - 09:20 09:20 - 09:25 Introductory Keynote Lecture Mary Dickinson - Houston 09:25 - 09:30 Imaging of Development: an Overview of 09:30 - 09:35 Dynamic Embryonic Events with a focus on 09:35 - 09:40 Central and Peripheral Nervous System Introduction to an experimental Hardware Approach of combining Assessing neurodegeneration, neuroinflammation and Human embryonic Posterior fossa venous development based on Internalisation movements of the endoderm during gastrulation in 09:40 - 09:45 MPI and MRI into an integrated Preclinical Hybrid Imaging System. neurogenesis in an experimental Parkinson's disease model using serial histologic 3D reconstruction. the zebrafish embryo. 09:45 - 09:50 Development Jochen Franke, Erlangen multimodal molecular imaging. Inga Fricke, Münster Romain Tonnelet, Nancy Florence Giger, Paris 09:50 - 09:55 Lee Niswander - Denver 09:55 - 10:00 Intravital Characterization of the inflammatory cells recruitment Rapid 3D light-sheet microscopy with a tunable lens. best poster presentation best poster presentation 10:00 - 10:05 during the development of Glioblastoma brain tumor. 10:05 - 10:10 Florian Fahrbach, Dresden poster session 1 poster session 2 10:10 - 10:15 Franck Debarbieux, Marseille 10:15 - 10:20 10:20 - 10:25 10:25 - 10:30 10:30 - 10:35 coffee break 10:35 - 10:40 10:40 - 10:45 10:45 - 10:50 Non-invasive 3-dimensional imaging of drosophila pupae and fly 10:50 - 10:55 using raster-scan optoacoustic mesoscopy (R-SOM). 10:55 - 11:00 In Vivo Imaging of the Developing Mouse Brain: Reconstructing multi scale in vivo imaging data by Murad Omar, Munich 11:00 - 11:05 Introductory Keynote Lecture From Morphology to Molecules multilevel dynamics 11:05 - 11:10 11:10 - 11:15 Lee Niswander - Denver Daniel Turnbull - New York Live-imaging reveals potential new mechanism of self-renewal. Nadine Peyriéras - Gif sur Yvette 11:15 - 11:20 Paula Alexandre, London 11:20 - 11:25 Coffee break & 11:25 - 11:30 Poster session 1 11:30 - 11:35 A Novel Live Imaging System for the Study of Epithelial Dynamics in poster # 1-10 Molecular Imaging Studies of the Developmental Emergence of 11:35 - 11:40 the Mammalian Embryo. Integrative Brain Function. 11:40 - 11:45 Ray Heather, Denver Evan Balaban - Montreal open discussion 11:45 - 11:50 open discussion 11:50 - 11:55 Live-imaging analysis of impacts of apoptosis on the cranial neural Vascular Resistivity Imaging using Ultrafast Doppler : application to conclusion 11:55 - 12:00 tube closure in mouse embryo. the 2D cerebral mapping of preterm infant vascular indexes.
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