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Masthead 2019
Masthead AngewandteA Journal of the German Chemical Society International Edition Chemie Editorial Board Chair: Annette G. Beck-Sickinger, Universität Leipzig Michael Brands, Bayer (Berlin) Editor: Neville A. Compton Holger Braunschweig, Julius-Maximilians-Universität (Würzburg) Martin Brudermüller, BASF (Ludwigshafen) Deputy Editors: Frank Maaß, Nathalie Weickgenannt Thomas Carell, Ludwig-Maximilians-Universität München Klaus Griesar, Merck (Darmstadt) Editorial Office: Senior Associate Editors: Jens Ackermann, Stefan Grimme, Universität Bonn Jonathan Faiz, Tamaryin Godinho, Hansjörg Grützmacher, Eidgenöss. Techn. Hochschule Zürich Nicole Harrington-Frost, Stephen Horner, (Switzerland) Volker Jacob, Guy Richardson, Rainer Haag, Freie Universität Berlin Rachel Schmidt-Radde, Diane Smith, Christian W. Kohlpaintner, Clariant (Pratteln, Switzerland) Xin Su, Suzanne Tobey Walter Leitner, Rheinisch-Westfälische Technische Hochschule Aachen Senior Web Editor: Mario Müller Wolfgang Parak, Universität Marburg Erwin Reisner, University of Cambridge (UK) Associate Editors: Eric Castro, Wolfgang Schnick, Ludwig-Maximilians-Universität München Arno Knappschneider, Kim Meyer Ferdi Schüth, Max-Planck-Institut für Kohlenforschung (Mülheim) Senior Assistant Editors: Gary Battle, Wolfgang Schuhmann, Ruhr-Universität Bochum Christiane Walter Harald Schwalbe, Johann Wolfgang Goethe-Universität Frankfurt Assistant Editors: Lisa Pecher, Petra Schwille, Max-Planck-Institut für Biochemie (Martinsried) Polina Smirnov, Laura Woodward Armido Studer, Westfälische -
9-10 September 2017
9-10 September 2017 oxfordpreservation.org.uk Contents and Guide A B C D E F G A44 A34 To Birmingham (M40) 1 C 1 h d a To Worcester and Northampton (A43) oa d R n l to i Lin n g t B o a n P&R n R b o P&R Water Eaton W u a r d Pear o y N Contents Guide o R o & d Tree o r s d t a a o h t R o n d o m ns c awli k R o Page 2 Page 12 – Thursday 7 Sept – City centre map R o A40 o r a R Oxford To Cheltenham d o a 2 d 2 Page 4 – Welcome Page 13 – Friday 8 Sept W d oodst A40 Roa et’s r Banbur arga Page 5 – Highlights - Hidden Oxford Page 15 – Saturday 9 Sept M St ock R A34 y R oad M arst anal oad Page 7 Pages 20 & 21 To London (M40) – Highlights - Family Fun – OPT – what we do ace on R d C n Pl A40 W so or wn en Oxford a To B oad xf lt ark O P o City Page 8 Page 29 n ad – OPT venues – Sunday 10 Sept o S R d n a F P&R Centre oad t o o y P&R r d R fi e rn Seacourt a ad m e ondon R e F o a L Thornhill ry R h l t r 3 rbu No d 3 e R Page 9 t – OPT member only events an o C a d B r Botley Road e a rad d ad a m o th P k R Abingdon R r o No Cric A4142 r e I ffley R R Co o wley R a d s oad oad d n oad oa de R ar A420 rd G Red – OPT venues, FF – Family friendly, R – Refreshments available, D – Disabled access, fo am To Bristol ck rh Le No ad (D) – Partial disabled access Ro 4 ton P&R 4 ing Bev Redbridge A34 To Southampton For more specific information on disabled access to venues, please contact OPT or the venue. -
New Jericho Health Centre Building University of Oxford Radcliffe Observatory Quarter Oxford
New Jericho Health Centre Building University of Oxford Radcliffe Observatory Quarter Oxford Archaeological Watching Brief for Longcross Construction Ltd CA Project: 3450 CA Report: 12024 May 2012 New Jericho Health Centre Building University of Oxford Radcliffe Observatory Quarter Oxford Archaeological Watching Brief CA Project: 3450 CA Report: 12024 prepared by Kelly Saunders, Project Supervisor date 26 April 2012 checked by Cliff Bateman, Project Manager date 11 May 2012 approved by Simon Cox, Head of Fieldwork signed date 24 May 2012 issue 01 This report is confidential to the client. Cotswold Archaeology accepts no responsibility or liability to any third party to whom this report, or any part of it, is made known. Any such party relies upon this report entirely at their own risk. No part of this report may be reproduced by any means without permission. © Cotswold Archaeology Building 11, Kemble Enterprise Park, Kemble, Cirencester, Gloucestershire, GL7 6BQ t. 01285 771022 f. 01285 771033 e. [email protected] © Cotswold Archaeology New Jericho Health Centre Building, Oxford: Archaeological Watching Brief CONTENTS SUMMARY........................................................................................................................ 2 1. INTRODUCTION ................................................................................................. 3 2. RESULTS (FIG. 2) ............................................................................................... 6 3. DISCUSSION...................................................................................................... -
Download the Program
The first International Congress of Neuroimmunology was held in Stresa, Italy, in 1982 and wasThe organized first International by Drs. Peter Congress O. Behan of Neuroimmunology and Federico Spreafico. was held The in secondStresa, Italy,International in Congress1982 and of wasNeuroimmunology organized by Drs. was Peter held O.in Philadelphia,Behan and Federico PA, and Spreafico. was organised The second by C.S. Raine andInternational Dale E. McFarlin. Congress It was of atNeuroimmunology this meeting in Philadelphiawas held in inPhiladelphia, 1987 that itPA, was and decided was to startorganised an international by C.S. Raine society, and the Dale International E. McFarlin. Society It was ofat Neuroimmunology,this meeting in Philadelphia and an election wasin 1987held forthat a it panel was decided of officers. to start C.S. anRaine international was elected society, President, the International John Newson-Davis Society Vice President,of Neuroimmunology, Robert Lisak andTreasurer an election and Kenethwas held Johnson for a panel Secretary, of officers. together Cedric with S. an InternationalRaine was Advisoryelected President,Board. The John Society Newson-Davis was incorporated Vice President,in 1988. Subsequent Robert Lisak meetings wereTreasurer in Jerusalem and Kenneth 1991 (Oder Johnson Abramsky Secretary, and togetherHaim Ovadia), with Amsterdaman International 1994 (KeeAdvisory Lucas), Board. Montreal 1998 (Jack Antel and Trevor Owens), Edinburgh 2001 (John Greenwood,The Society Sandra was Amor,incorporated David Baker, in 1988.John -
Selfish Genes Jon Arvid Agren, Greg Hurst
2017-10-25 Selfish Genes - Evolutionary Biology - Oxford Bibliographies Selfish Genes Jon Arvid Agren, Greg Hurst LAST MODIFIED: 25 OCTOBER 2017 DOI: 10.1093/OBO/97801999417280094 Introduction In its original formulation, Darwin’s theory of evolution by natural selection was based upon individual organisms. It is individuals that vary in phenotype, individuals that struggle to survive environmental pressures and compete over access to mates, and individuals that vary in fitness according to phenotype. Selfish gene theory, or the gene’seye view of evolution, however, offers a radically different picture of evolution by natural selection. Tracing its origins to the emergence of population genetics during the modern synthesis of the 1930s, especially to the writings of R. A. Fisher, as well as the social evolution models of W. D. Hamilton, the most ambitious form of the gene’s eye view was spelled out in two later books: George Williams’s Adaptation and Natural Selection (1966) and Richard Dawkins’s The Selfish Gene (1976). Under this view of life, the fundamental unit of selection is the gene. Whereas individual organisms are temporary occurrences—present in one generation, gone in the next—genes are potentially immortal and their structure is passed on from generation to generation. As a consequence, the ultimate beneficiary of selection is the gene. Early on in The Selfish Gene, Dawkins relates this crucial insight as follows: “They are in you and me; they created us, body and mind; and their preservation is the ultimate rationale for our existence. They have come a long way, those replicators. Now they go by the name of genes, and we are their survival machines” (p. -
Living with New Developments in Jericho and Walton Manor
LIVING WITH NEW DEVELOPMENTS IN JERICHO AND WALTON MANOR A discussion paper examining the likely impacts upon the neighbourhood of forthcoming and expected developments Paul Cullen – November 2010 1. Introduction 2. Developments approved or planned 3. Likely effects of the developments 3.1 More people living in the area. 3.2 More people visiting the area daily 3.3 Effects of construction 4. Likely outcomes of more residents and more visitors 4.1 More activity in the neighbourhood every day 4.2 More demand for shops, eating, drinking and entertainment 4.3 More vehicles making deliveries and servicing visits to the area 4.4 More local parking demand 4.5 Demand for places at local schools will grow 5. Present day problems in the neighbourhood 5.1 The night-time economy – and litter 5.2 Transient resident population 5.3 Motor traffic congestion and air pollution 5.4 Narrow and obstructed footways 6. Wider issues of travel and access 6.1 Lack of bus links between the rail station and Woodstock Road 6.2 Lack of a convenient pedestrian/cycle link to the rail station and West End 6.3 The need for travel behaviour change 7. The need for a planning led response 7.1 Developer Contributions 7.2 How should developers contribute? 7.3 What are the emerging questions? 8. Next steps – a dialogue between the community, planners and developers 1 LIVING WITH NEW DEVELOPMENTS IN JERICHO AND WALTON MANOR A discussion paper examining the likely impacts upon the neighbourhood of forthcoming and expected developments 1. Introduction Many new developments are planned or proposed in or near Jericho and these will have a substantial impact on the local community. -
The Selfish Gene by Richard Dawkins Is Another
BOOKS & ARTS COMMENT ooks about science tend to fall into two categories: those that explain it to lay people in the hope of cultivat- Bing a wide readership, and those that try to persuade fellow scientists to support a new theory, usually with equations. Books that achieve both — changing science and reach- ing the public — are rare. Charles Darwin’s On the Origin of Species (1859) was one. The Selfish Gene by Richard Dawkins is another. From the moment of its publication 40 years ago, it has been a sparkling best-seller and a TERRY SMITH/THE LIFE IMAGES COLLECTION/GETTY SMITH/THE LIFE IMAGES TERRY scientific game-changer. The gene-centred view of evolution that Dawkins championed and crystallized is now central both to evolutionary theoriz- ing and to lay commentaries on natural history such as wildlife documentaries. A bird or a bee risks its life and health to bring its offspring into the world not to help itself, and certainly not to help its species — the prevailing, lazy thinking of the 1960s, even among luminaries of evolution such as Julian Huxley and Konrad Lorenz — but (uncon- sciously) so that its genes go on. Genes that cause birds and bees to breed survive at the expense of other genes. No other explana- tion makes sense, although some insist that there are other ways to tell the story (see K. Laland et al. Nature 514, 161–164; 2014). What stood out was Dawkins’s radical insistence that the digital information in a gene is effectively immortal and must be the primary unit of selection. -
Plasma from Human Mothers of Fetuses with Severe Arthrogryposis Multiplex Congenita Causes Deformities in Mice
Plasma from human mothers of fetuses with severe arthrogryposis multiplex congenita causes deformities in mice Leslie Jacobson, … , Gillian Morriss-Kay, Angela Vincent J Clin Invest. 1999;103(7):1031-1038. https://doi.org/10.1172/JCI5943. Article Arthrogryposis multiplex congenita (AMC) is characterized by fixed joint contractures and other deformities, sometimes resulting in fetal death. The cause is unknown in most cases, but some women with fetuses affected by severe AMC have serum antibodies that inhibit fetal acetylcholine receptor (AChR) function, and antibodies to fetal antigens might play a pathogenic role in other congenital disorders. To investigate this possibility, we have established a model by injecting pregnant mice with plasma from four anti-AChR antibody–positive women whose fetuses had severe AMC. We found that human antibodies can be transferred efficiently to the mouse fetus during the last few days of fetal life. Many of the fetuses of dams injected with AMC maternal plasmas or Ig were stillborn and showed fixed joints and other deformities. Moreover, similar changes were found in mice after injection of a serum from one anti-AChR antibody–negative mother who had had four AMC fetuses. Thus, we have confirmed the role of maternal antibodies in cases of AMC associated with maternal anti-AChR, and we have demonstrated the existence of pathogenic maternal factors in one other case. Importantly, this approach can be used to look at the effects of other maternal human antibodies on development of the fetus. Find the latest version: https://jci.me/5943/pdf Plasma from human mothers of fetuses with severe arthrogryposis multiplex congenita causes deformities in mice Leslie Jacobson,1 Agata Polizzi,1 Gillian Morriss-Kay,2 and Angela Vincent1 1Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom 2Department of Human Anatomy and Genetics, University of Oxford, Oxford, United Kingdom. -
EMBO Conference Takes to the Sea Life Sciences in Portugal
SUMMER 2013 ISSUE 24 encounters page 3 page 7 Life sciences in Portugal The limits of privacy page 8 EMBO Conference takes to the sea EDITORIAL Maria Leptin, Director of EMBO, INTERVIEW EMBO Associate Member Tom SPOTLIGHT Read about how the EMBO discusses the San Francisco Declaration Cech shares his views on science in Europe and Courses & Workshops Programme funds on Research Assessment and some of the describes some recent productive collisions. meetings for life scientists in Europe. concerns about Journal Impact Factors. PAGE 2 PAGE 5 PAGE 9 www.embo.org COMMENTARY INSIDE SCIENTIFIC PUBLISHING panels have to evaluate more than a hundred The San Francisco Declaration on applicants to establish a short list for in-depth assessment, they cannot be expected to form their views by reading the original publications Research Assessment of all of the applicants. I believe that the quality of the journal in More than 7000 scientists and 250 science organizations have by now put which research is published can, in principle, their names to a joint statement called the San Francisco Declaration on be used for assessment because it reflects how the expert community who is most competent Research Assessment (DORA; am.ascb.org/dora). The declaration calls to judge it views the science. There has always on the world’s scientific community to avoid misusing the Journal Impact been a prestige factor associated with the publi- Factor in evaluating research for funding, hiring, promotion, or institutional cation of papers in certain journals even before the impact factor existed. This prestige is in many effectiveness. -
Smutty Alchemy
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2021-01-18 Smutty Alchemy Smith, Mallory E. Land Smith, M. E. L. (2021). Smutty Alchemy (Unpublished doctoral thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/113019 doctoral thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Smutty Alchemy by Mallory E. Land Smith A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENGLISH CALGARY, ALBERTA JANUARY, 2021 © Mallory E. Land Smith 2021 MELS ii Abstract Sina Queyras, in the essay “Lyric Conceptualism: A Manifesto in Progress,” describes the Lyric Conceptualist as a poet capable of recognizing the effects of disparate movements and employing a variety of lyric, conceptual, and language poetry techniques to continue to innovate in poetry without dismissing the work of other schools of poetic thought. Queyras sees the lyric conceptualist as an artistic curator who collects, modifies, selects, synthesizes, and adapts, to create verse that is both conceptual and accessible, using relevant materials and techniques from the past and present. This dissertation responds to Queyras’s idea with a collection of original poems in the lyric conceptualist mode, supported by a critical exegesis of that work. -
Autoimmune Encephalitis
Autoimmune encephalitis Angela Vincent and the Neurosciences Group Nuffield Department of Clinical Neurosciences, Oxford University, UK Disclosures Angela Vincent and the University of Oxford hold patents, and receive royalties and payments for antibody tests including VGKC-complex antigens LGI1 and CASPR2 Angela Vincent has recently received honoraria for lectures from GSK, UCB Pharma and Serono This is the version that should have been presented – slightly different from that you saw Autoantibodies causing neurological diseases From myasthenia to encephalitis and a growing number of wider conditions The neuromuscular junction in myasthenia AChRs Muscle fibre Antibodies cause loss of the AChRs Patients improve with treatments that reduce the AChR antibody levels Plasma exchange for myasthenia John Newsom-Davis Newsom-Davis et al 1978 1932-2007 Crisp, Kullmann and Vincent Nature Reviews Neuroscience 2016 Antibody-mediated diseases Antibodies that bind to extracellular domain of membrane protein on target tissue Antibodies measured easily in serum (and cerebrospinal fluid (CSF) if relevant) Antibodies cause loss of the target protein and/or damage to the cell Patients can improve with immunotherapies: steroids, plasma exchange, intravenous immunoglobulins Pathogenicity can be demonstrated by animal studies MG with MuSK antibodies, AChR antibodies negative Plasma exchange provided a diagnostic test! But long-term marked and persistent facial weakness and atrophy, difficult to treat Patient of John Newsom-Davis; courtesy of patient MuSK-MG -
Eg Phd, Mphil, Dclinpsychol
This thesis has been submitted in fulfilment of the requirements for a postgraduate degree (e.g. PhD, MPhil, DClinPsychol) at the University of Edinburgh. Please note the following terms and conditions of use: This work is protected by copyright and other intellectual property rights, which are retained by the thesis author, unless otherwise stated. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the author. The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the author. When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given. Regulation of Intestinal Regulatory T cells by Prostaglandin E2 Siobhan Crittenden A thesis submitted for the degree of Doctor of Philosophy The University of Edinburgh Year 2018 Declaration I declare that this thesis has been submitted by myself, describes my own work except where indicated throughout the thesis, and has not been submitted in any other application for a higher degree. Siobhan Crittenden 11th April 2018 1 Acknowledgements I would firstly like to thank my supervisor Dr Chengan Yao for all the help and support he has given me during my time at Edinburgh. Additionally, my thanks go to my co- supervisors Professor Sarah Howie and Professor Stephen Anderton for their time and guidance. I need to acknowledge our collaborators, Professor Rick Maizels, Professors Adriano Rossi, Peter Ghazal and Jack Satsangi.