The Editor of The Journal of Pharmacology and Experimental Therapeutics wishes to express appreciation to the following colleagues who acted at Guest Editors for Specific Fields in 1994.

Martin W. Adler Allan M. Lefer Edson X. Albuquerque Roberto Levi Vernon S. Bishop Benedict R. Lucchesi Theodore J. Cicero Irwin LucId Marlene L. Cohen David R. Manning Alan Frazer William H. Morse Robert Freedman Garth Powis Eitan Friedman Roger D. Spealman Ray W. Fuller Milt Teitler Richard Gillis Mary Vore Elizabeth H. Jeffery Michael Williams

Additionally, sincere thanks are due to 1039 of our colleagues not on the Editorial Advisory Board who reviewed articles for the Journal in 1994. Their contributions are acknowledged individually in the Annual Report of The Journal to The Board of Publications Trustees of The American Society for Pharmacology and Experimental Therapeutics. INDEX

Volume 273, April-June, 1995

A-85653, repeated daily, effects on rota- tor binding and in vivo activities beta-i, effects in SNS-evoked adrenal tion and striatal c-fos expression, for anandamide analogs, 1172 catecholamine release, in anes- 1483 Adams, J. L., see Chabot-Fletcher, M. C., thetized dogs, 1337 Abecarnil, modulation of basal and stress- 1147 Advenier, C., see F#{233}l#{233}tou,M., 1071 induced release of acetyicholine Adams, J. U., see Liu-Chen, L.-Y., 1047 Afferent nerves, capsaicin-sensitive, regu- and dopamine in rat brain by, 241 Adams, M., see Cicero, T. J., 386 lation of jejunal arterioles by, in Absence seizures, GHB-induced, endoge- Adenosine, metabolism of exogenous cyclic N. brasiliensis-sensitized rats, nous GABA in, in rat, 1534 AMP to, in rat kidney, 728 337 [3HIABT-418, receptor binding character- Adenosine analogues, TNF-a inhibition v-Agatoxin-IVA, blockade of voltage- istics, in rat brain, 1434 by, 1506 sensitive calcium channels by, at Abuse, see Alcohol abuse; Drug abuse Adenosine receptors mouse neuromuscular junction, Acetaminophen, cytotoxicity in human A1 248 CYP2E1-transfected HepG2 cells, interaction with caffeine, effects on Ahmed, M. S., see Cemerikic, B., 987 1497 hippocampal acetyicholine re- Ahmmed, G. U., see Yoshida, A., 702 Acetylcholine lease, 637 Akai, T., Ozawa, M., Yamaguchi, M., basal and stress-induced release, modu- potassium current activated by, char- Mizuta, E. and Kuno, S.: Combi- lation by abecarnil and imidaze- acterization of, in rat locus cer- nation treatment of the partial nil, in rat brain, 241 uleus neurons, 537 D2 agonist terguride with the D1 hippocampal release, caffeine effects on, agonist modulation of intraocular pres- agonist SKF 82958 in 1-methyl- 4-phenyl-i,2,3,6-tetrahydropyri- 637 sure by, in rabbits, 320 interaction with K channel blockers, Adenylate cyclase dine-lesioned parkinsonian cyno- molgus monkeys, 309 effects on atrial repolarization, beta adrenergic response of, in rat brain, Akima, M., see Takanashi, H., 624 1095 415 Albumin, serum, role in nitric oxide dose- Na influx and catecholamine secretion bradykinin inhibition of, colon contrac- response, in isolated perfused rat evoked by, reduction by ginseng tion evoked by, 344 kidney, 855 saponins, in bovine adrenal chro- Adhesion molecules, role in cardiovascular Albuquerque, E. X., see Ishihara, K., 1459, maffin cells, 629 pharmacology, meeting review, 1471 signal transduction pathways in gall- 569 Albuterol, salmeterol blockade of inhibi- bladder muscle, 650 Adler, M. W., see Belkowski, S. M., 1491 tion of eosinophil secretion by, Acetylcholine receptors Adrenal chromaffin cells, ACh-evoked 850 muscarinic Na influx and catecholamine se- Alcohol abuse, promotion by low brain do- bladder subtypes, 959 cretion in, reduction by ginseng pamine, 373 gallbladder muscle subtypes, 650 saponins, in bovine, 629 Alfentanil, antinociceptive effects in tail- interaction with K channel blockers, Adrenal gland, catecholamine release in, withdrawal procedure, buprenor- effects on atrial repolarization, SNS-evoked, effects of beta adre- phine antagonism of, in rhesus noceptors in, in anesthetized 1095 monkey, 1345 regulation of cardiac CFTR Cl cur- dogs, 1337 Alicea, C., see Belkowski, S. M., 1491 Adrenergic nerves, ear artery, facilitatory rent by, effects of quaternary am- Alkondon, M., see Ishihara, K., 1459, 1471 prejunctional purinoceptors on, monium compounds on, 470 Allavena, A., see Martelli, A., 113 role in cicletanine effects on kidney in rabbit, 1390 Allergy function, 1197 Adrenergic neurons, modulation by SB 202235 asthmatic effects in, in mod- nicotinic 5-HT1A receptors, in rat, 1032 els, 1147 ABT-418 binding characteristics, in Adrenergic receptors trimellitic anhydride, role of comple- rat brain, 1434 alpha-2 ment system in, in lung, 793 hippocampal, lead effects on, in rat, medullary, effects in conscious spon- Ailing, K., see Pell#{243}n, R., 138 1471 taneously hypertensive rats, 1162 Alloantigen, specific CTL activity, effects Acid secretion, in gastric glands, effects of modulation of spinal sympathetic re- of exogenous corticosterone on, in PDE IV inhibitors on, in rabbit, flex by, in rat, 380 mice, 823 1396 13H]RX 821002 vs [3H]rauwolscine Allografts, heart, gramicidin prolongation Action potential, dimethyl sulfoxide ef- binding, in nine tissues and cell of survival, in rat, 223 fects on, in guinea pig ventricular lines, 1287 Aloyo, V. J., Ruffin, J. S., Pazdalski, P. 5., preparations, 1273 alpha-i, agonist preconditioning, in rat Kirifides, A. L. and Harvey, J. A.: Action potential duration, effects of inter- hearts, 689 [3H]WIN 35,428 binding in the action between K channel block- beta caudate nucleus of the rabbit: Ev- ers and acetylcholine on, 1095 brain signaling, in rat, 415 idence for a single site on the do- Activated protein C, antiinflammatory ef- effects in SNS-evoked adrenal cate- pamine transporter, 435 fects, in rat models, 193 cholamine release, in anesthe- Alper, S. L., see Brugnara, C., 266 Activity stress gastric lesions, dopamine tized dogs, 1337 Amantadine, renal transport, site-selec- Dl and D2 receptor effects in, in beta-2 tive effect of bicarbonate on, 72 rats, 1001 effects in SNS-evoked adrenal cate- Ambler, S. J., see Chrandasekhar, S., 1519 Adams, I. B. , Ryan, W., Singer, M., cholamine release, in anesthe- y-Aminobutyric acid Thomas, B. F., Compton, D. R., tized dogs, 1337 ethanol interaction, prediction by zolpi- Razdan, R. K. and Martin, B. R.: salmeterol blockade of eosinophil in- dem effects on GABA-induced in- Evaluation of cannabinoid recep- hibition by, 850 hibition, in rat brain regions, 526 1562 Index Vol. 273

in GHB-induced absence seizures, in Anorectic agents, effects on deprivation- sympathetic vasoconstriction of, modu- rat, 1534 induced feeding and taste aver- lation by sensory nerves and NO 5-HT interactions in substantia nigra, sion conditioning, in rats, 1203 in, in rat iris, 918 modulation of MDMA-induced Antiarrhythmics Ashkenazi, I. E., see Gozes, I., 161 striatal dopamine release by, class-I-type, sodium channel blockade Asin, K. E., Bednarz, L., Nikkel, A. and 1063 by, postischemia, 1403 Perner, R.: Rotation and striatal presynaptic GHB and GABAB receptor- electrophysiologic effects c-fos expression after repeated, mediated release of, in rat tha- effects of infarct healing on, 315 daily treatment with selective do- lamic ventrobasal nucleus, 1534 in guinea pig cardiac isolated prepa- pamine receptor agonists and -y-Aminobutyric acidB, presynaptic inhibi- rations, 1264 levodopa, 1483 tion by adenosine, in midbrain inhibition of G-protein and K channels Asthma, allergic, SB 202235 effects in, in dopamine neurons, 576 by, in thyroid cells, 702 models, 1147 2-Amino-N-(1,2-diphenylethyl)acetamide Antibiotics, (3-lactam, intestinal transport, Atenolol, effects in SNS-evoked adrenal hydrochloride, anticonvulsant ef- in rat, rabbit and human small catecholamine release, in anes- ficacy/safety properties of, 1023 intestines, 26 thetized dogs, 1337 p-Aminohippurate, renal transport, in Antigen, 6-THC modulation of macro- ATRA, see Retinoic acid rabbit renal basolateral mem- phage processing of, 1216 Atrial natriuretic peptide, endothelin ef- brane vesicles, 146 Antimalarials, amodiaquine metabolism fects dependent on, modulation by inhibitors Aminopyrine, secretion in gastric glands, and activity, effects of chemical of neutral endopep- effects of PDE N inhibitors on, in substitution on, in mouse, 393 tidase and cGMP-PDE, 744 rabbit, 1396 Antinociception Atrial repolarization, effects of interaction Ammonium, quaternary compounds, mus- anandamide, in mice, 1235 between K channel blockers and carinic regulation of cardiac 9-THC, anandamide blockade of, in acetylcholine on, 1095 Audinot, V., see Gobert, A., 1032; Milan, CFTR Cl current by, 470 mice, 1235 M. J., 1418; Schreiber, R., 101 Amodiaquine, metabolism and activity, ef- dynorphin A-(2-17) naloxone-insensi- Auta, J., see Thompson, D. M., 1307 fects of chemical substitution on, tive, in writhing assay, 802 Autoradiography, localization and charac- in mouse, 393 fluoroanandamide, in mice, 1235 terization of[3H]a-trinositol bind- Amphetamine, dose-related effects on zif/ intrathecal clonidine, mediation by spi- ing sites, in human and mamma- 268 and preprodynorphin mRNA nal nonadrenergic imidazoline re- ceptors, in rat, 1057 han tissues, 461 expression, in rat forebrain, 909 morphine, tolerance to, prevention with Autoreceptors Analgesia, see also Antinociception irreversible opioid antagonists, muscannic, m2 subtype identification, morphine, sensitivity to, adverse effects 680 in rat striatum, 273 of paternal opiates exposure on, mu opioid serotornnlA, modulation of, in rat, 1032 386 buprenorphine antagonism of, in rhe- Aversive agents, effects on deprivation- Anandamide, antinociceptive effects, in sus monkey tail-withdrawal pro- induced feeding and taste aver- mice, 1235 cedure, 1345 sion conditioning, in rats, 1203 Anandamide analogs, cannabinoid recep- neonatal sensitivity to, in rat, 1353 tor binding and structure-activity Bahr, B. A., Tiriveedhi, S., Park, G. Y. and after noxious thermal stimulation of one relationships, i172 Lynch, G.: Induction of calpain- hindpaw, mediation by -, - and Anderson, D. J., Williams, M., Pauly, J. R., mediated spectrin fragments by K-opiate receptors, in rat tail flick Raszkiewicz, J. L., Campbell, J. E., pathogenic treatments in long- test, 1428 Rotert, G., Surber, B., Thomas, term hippocampal slices, 902 supraspinal opioidlclonidine, NAC-j3- S. B., Wasicak, J., Arneric, S. P. Banerjee, P. K. and Snead, 0. C. III: Pre- END effects on mastoparan re- and Sullivan, J. P.: Characteriza- synaptic gamma-hydroxybutyric duction of, in mice, 787 acid (GHB) andgamma-aminobu- tion of [3HJABT-418: A novel cho- Aorta linergic channel ligand, 1434 tyric acidB (GABAB) receptor- contraction of, estradiol 17 3 inhibition Anderson, R. J., see Kudlacek, P. E., 582 mediated release of GABA and of, in rat, 1544 glutamate (GLU) in rat thalamic Anemia, dapsone-induced hemolytic, 870 glibenclamide analog antagonism of ventrobasal nucleus (VB): A pos- Anesthesia, local, effects in cardiovascular levcromakalim in, in rat, 778 sible mechanism for the genera- response to cocaine, in conscious 15-HPETE and 15-HETE pharmacody- tion of absence-like seizures in- rabbits, 128 namics in, in guinea pig, rabbit, duced by GHB, 1534 Anesthetics, inhalational, effects on nitric rat, 1182 Baraban, S. C., Lothman, E. W., Lee, A. oxide synthase, 599 Appleby, S. D., see Wallace, A. A., 168 and Guyenet, P. G.: Kappa opioid ANG, see Angiotensin Araki, M., see Kanda, T., 955 receptor-mediated suppression of Angiotensin II Archer, S., see Jiang, Q., 680 voltage-activated potassium cur- AT1 receptor antagonists Arginine, synthesis from citrulline, in ce- rent in a catecholaminergic neu- cerebroventricular, effects on ANG II- rebral perivascular nerves, 895 ronal cell line, 927 induced hypertension, 611 Armsby, C. C., see Brugnara, C., 266 Barnathan, E. S., see Okada, S. S., 948 effects on gene expression of TGF-131 Arndt, M. L., see Fraser, D. G., 793 Barnes, P. J., see Tsukagoshi, H., 1257 and extracellular matrix, in car- Arneric, S. P., see Anderson, D. J., 1434 Barnette, M. S., Grous, M., Cieslinski, L. diac and vascular tissues of hy- Arnolda, L., see Ng, C. Y., 1332 B., Burman, M., Christensen, S. pertensive rats, 509 Arrhythmias G. and Torphy, T. J.: Inhibitors of nonpeptide, functional studies of, 753 effects of phenylephrine-induced pre- phosphodiesterase IV (PDE IV) effects on mesangial cell proliferation conditioning on, in rat hearts, 689 increase acid secretion in rabbit and handling of IgG complexes, tedisamil effects against, 168 isolated gastric glands: Correla- heparin modulation of, 80 Arteries, i5-HPETE and 15-HETE phar- tion between function and inter- hypertensive effects, effects of cerebro- macodynamics in, in guinea pig, action with a high-affinity roli- ventricular EXP 3174 on, 611 rabbit, rat and human, 1182 pram binding site, 1396 renal effects, in young genetically hyper- Arterioles Barnette, M. S., Manning, C. D., Cieslin- tensive rats, 768 capsaicin-induced dilation of, in rat stn- ski, L. B., Burman, M., Chris- Angus, P. W., see Ng, C. Y., 1332 ated muscle, 605 tensen, S. B. and Torphy, T. J.: Anions, renal transport, in rabbit renal jejunal, regulation by capsaicin-sensi- The ability of phosphodiesterase basolateral membrane vesicles, tive nerves, in N. brasiliensis- N inhibitors to suppress superox- 146 sensitized rats, 337 ide production in guinea pig eosi- 1995 Index 1563

nophils is correlated with inhibi- Biggio, G., see Dazzi, L., 241 the mouse neuromuscular junc- tion of phosphodiesterase IV Billard, W., Binch, H. III, Crosby, G. and tion by novel o-conopeptides and catalytic activity, 674 McQuade, R. D.: Identification of to-agatoxin-NA, 248 Barter, R. A., see Liu, J., 977 the primary muscarinic autore- Bradshaw, M., Rutherford, M. S., Hoeper, Basilar artery, effects of activation of ETB ceptor subtype in rat striatum as B. J., McWhinney, C. D., receptors on, 1 m2 through a correlation of in Borcherding, D. R., Schook, L. B. Basile, A. S., see Yurdaydin, C., 185 vivo microdialysis and in vitro re- and Edwards, C. K III: Specific Baskin, E. P., see Wallace, A. A., 168 ceptor binding data, 273 transcriptional inhibition of bone Baumann, M. H., see Silverthorn, M. L., Bilsky, E. J., Calderon, S. N., Wang, T., marrow-derived macrophage tu- 213 Bernstein, R. N., Davis, P., mor necrosis factor-a gene ex- Beck, S. G., see Birnstiel, S., 1132 Hruby, V. J., McNutt, R. W., pression and protein production Becketts, K. M., see Silverthorn, M. L., 213 Rothman, R. B., Rice, K. C. and using novel enantiomeric carbo- Bednarz, L., see Asin, K. E., 1483 Porreca, F.: SNC 80, a selective, cyclic nucleoside analogues, 1506 Behar, J., see Chen, Q., 650 nonpeptidic and systemically ac- Bradykinin, colon contraction evoked by, Behar, J., see Sohn, U. D., 482 tive opioid delta agonist, 359 344 Behavior Binch, H. III, see Billard, W., 273 Bradykinin receptors Birkemo, L. S., see Ervin, G. N., 1203 DOI-induced head-twitches, mediation B2, S 16118 antagonist effects, 1071 by 5-HT2A receptors, in rat, 101 Birnstiel, S. and Beck, S. G.: Modulation of in in vivo animal models of inflamma- opioid effects in midbrain tegmentum, the 5-hydroxytryptamine4 recep- tion, 1078 327 tsr-mediated response by short- IL-ij3 effects on, in rat lung, 1257 schedule-controlled, D1 and D2 agonist term and long-term administra- subtypes in rat lung, 1257 effects on, in squirrel monkeys, tion of corticosterone in rat CAl Brain 40 hippocampal pyramidal neurons, [3H}ABT-418 receptor binding charac- scratching, D2 agonist effects on, phar- 1132 teristics in, in rat, 1434 macological analysis, in squirrel Bladder, urinary, muscarinic receptor sub- monkeys, 138 types, 959 acetylcholine and dopamine release in, basal and stress-induced, modu- tail-flick test Blake, D. R., see Walsh, D. A., 461 buprenorphine antagonism of mu opi- Blastogenesis, human lymphocyte, grami- lation by abecarnil and imidaze- oids in, in rhesus monkey, 1345 cidin suppression of, in rat, 223 nil, in rat, 241 opiate mediation of effects of noxious Blood-brain barrier beta receptor signaling in, in rat, 415 thermal stimulation of one hind- 5-HT3 receptors in, antagonist anti- diazepam binding inhibitor mRNA 1ev- paw on, in rat, 1428 emetic effects, in dogs, 695 els, effects of ethanol dependence Belkowski, S. M., Alicea, C., Eisenstein, T. peptide transport across, verapamil ef- and withdrawal on, in mice, 1529 K., Adler, M. W. and Rogers, T. J.: fects on, in rats, 298 low dopamine function in, promotion of Inhibition of interleukin-1 and Blood flow alcohol abuse by, 373 tumor necrosis factor-a synthesis diabetic, effects of evening primrose oil membrane [251]RTI-55 binding sites, following treatment of macro- on, in rats, 49 demonstration of, in rat, 213 phages with the kappa opioid ag- hepatic, effects of right heart failure on, opioid peptide levels, with thioacet- onist U50,488H, 1491 in rats, 1332 amide-induced fulminant hepatic Benet, L. Z., see Hay-Yehia, A. I., 94 Blood plasma, L-dopa pharmacokinetics failure, in rats, 185 Benzodiazepine in, effects of carbidopa and enta- IL opioid receptor binding in, in rat, ef- cognitive effects, imidazenil reduction capone on, in beagle dog, 1323 fects of intracerebroventricular of, in monkeys, 1307 Blood vessels 13-funaltrexamine on, 1047 receptors in rat spinal cord, heteroge- AT1 receptor antagonist effects on gene [3H]SR 48692 binding sites in, in guinea neity resolution with FASA and expression of TGF-/31 and extra- pig, 1450 LIGAND, 842 cellular matrix in, in hyperten- ventral tegmental area neurons in, eth- withdrawal, gastric emptying distur- sive rats, 509 ano! excitation of, serotonin po- bance induced by, in rats, 995 nitrovasodilator potency and selectivity tentiation of, in rat slices, 1139 Berger, H., see Kertscher, U., 709 on, in human, 154 zolpidem effects on GABA-induced inhi- Bergman, J., Rosenzweig-Lipson, S. and Bonanno, G., see Raiteri, M., 643 bition, prediction of ethanol- Spealman, R. D.: Differential ef- Bond, M., see Pogue, D. H., 863 GABA interaction by, in rat, 526 fects of dopamine D1 and D2 re- Bone marrow Brambilla, G., see Martelli, A., 113 macrophage TNF-a from, adenosine an- ceptor agonists on schedule-con- Brambilla Campart, G., see Martelli, A., trolled behavior of squirrel alogue inhibition of, 1506 113 monkeys, 40 uptake of nartograstim by, in rats, 1114 Br#{228}ndle,E., see Greven, J., 1197 Berndt, N., see Runnegar, M. T., 545 Bonnafous, C. , Lefevre, P. and Bueno, Brater, D. C., see Rudy, A. C., 88 Bernstein, R. N., see Bilsky, E. J., 359 L.: Benzodiazepine-withdrawal- Breese, G. R., see Criswell, H. E., 526 Berryman, K. A., see Reynolds, E. E., 1410 induced gastric emptying distur- Breimer, D. D., see Math#{244}t,R. A. A., 405 Bertrand, P., see Pendley, C. E., 1015 bances in rats: Evidence for sero- Brenneman, D. E., see Gozes, I., 161 Bervoets, K., see Millan, M. J., 1418 tonin receptor involvement, 995 Breslow, R., see Showell, H. J., 176 Betancur, C., Canton, M., Gully, D., Vela, Bonnardel, E., see F#{233}l#{233}tou,M., 1071 Breton, J. J., see Chabot-Fletcher, M. C., G., P#{233}laprat, D. and Rost#{232}ne,W.: Borchardt, R. T., see Chikhale, E. G., 298 Characterization and distribution Borcherding, D. R., see Bradshaw, M., 1147 of binding sites for a new neuro- 1506 Bril, A., Faivre, J.-F., Forest, M.-C., tensin receptor antagonist ligand, Botella, A., Delvaux, M., Fioramonti, J., Cheval, B., Gout, B., Lin#{233}e,P., [3H]SR 48692, in the guinea pig Frexinos, J. and Bueno, L.: Re- Ruffolo, R. R., Jr. and Poyser, brain, 1450 ceptor subtypes involved in dual R. H.: Electrophysiological effect Bhatti, T., see Thomas, G., 1544 effects induced by prostaglandin of N-(3,4-dimethoxyphenyl)-N- Biancani, P., see Chen, Q., 650 E2 in circular smooth muscle from [3[[2-(3,4-dimethoxyphenyl)eth- Biancani, P., see Sohn, U. D., 482 dog colon, 1008 yl]propyl]-4-nitrobenzamide hy- Bianchi, R. G., see Gullikson, G. W., 1123 Bowersox, S. S., Miljanich, G. P., Sugiura, drochloride (BRL-32872), a novel Bicarbonate, site-selective effect on aman- Y., Li, C., Nadasdi, L., Hoffman, antiarrhythmic agent with potas- tadine renal transport, 72 B. B.,Ramachandran, J.,Ko, C-P.: sium and calcium channel block- Bidlack, J. M., see Jiang, Q., 680 Differential blockade of voltage- ing properties, in guinea pig car- Biggers, M. S., see Showell, H. J., 176 sensitive calcium channels at diac isolated preparations, 1264 1564 Index Vol. 273

BRL-32872, electrophysiological effects, in phine tolerance in, in rat spinal membrane cholesterol content in, lova- guinea pig cardiac isolated prep- cord, 887 statin effects on, in normal and arations, 1264 Calcium cardiomyopathic hamsters, 863 Brocco, M., see Millan, M. J., 1418 mitochondrial injury, verapamil effects Cardiovascular system Brocco, M., see Schreiber, R., 101 against, 206 R- and 5-PIA effects in, pharmaco- Brockington, A., see Silverthorn, M. L., urine concentrations, effects and inter- kinetic-pharmacodynamic model- 213 actions of gentamicin, polyaspar- ling of, in conscious normotensive Brodie, M. S., Trifunovic, R. D. and tic acid and diuretics on, 280 rats, 405 Shefner, S. A.: Serotonin potenti- Calcium-activated potassium channels, role of adhesion molecules in, meeting ates ethanol-induced excitation of human erythrocyte, blockade by review, 569 ventral tegmental area neurons oral clotrimazole, 266 Carrageenan, pleurisy induced by, L-NMA in brain slices from three differ- Calcium channel blockers, effects on vas- reduction of, in rat, 1295 ent rat strains, 1139 cular smooth muscle cells, 32 Carroll, F. I., see Silverthorn, M. L., 213 6-(2-Bromophenyl)-8-fluoro-4-H-imi- Calcium channels Carter, A. J., O’Connor, W. T., Carter, M. dazo[l-5-al[l-4]benzodiazepine- dimethyl sulfoxide effects on, in guinea J. and Ungerstedt, U.: Caffeine 3-carboxamide, see Imidazenil pig ventricular preparations, enhances acetylcholine release in Bromosulfophthalein-glutathione conju- the hippocampus in vivo by a se- 1273 gate, renal disposition, in rat, lective interaction with adenosine voltage-sensitive 1300 A1 receptors, 637 blockade by w-conopeptides and Brudel, M., see Kertscher, U., 709 Carter, G., see Tracey, W. R., 1295 w-agatoxin-NA, at mouse neuro- Brugnara, C., Armsby, C. C., Sakamoto, Carter, M. J., see Carter, A. J., 637 muscular junction, 248 M., Rifai, N., Alper, S. L. and Carvedilol ruthenium red effects on, 940 Platt, 0.: Oral administration of effects in SAO shock, in rats, 64 Calciuresis, gentamicin-mediated, 280 clotrimazole and blockade of hu- inhibition of LDL oxidation by vascular man erythrocyte Ca k-activated Calderon, S. N., see Bilsky, E. J., 359 smooth muscle cells by, 1442 K channel: The imidazole ring is Calpain, spectrin proteolysis mediated by, Casler, J. J., see Gullikson, G. W., 1123 induction by pathogenic treat- not required for inhibitory activ- Castelli, I., see Kaufmann, M. A., 855 ity, 266 ments in long-term hippocampal Catecholamine, SNS-evoked adrenal re- BSP-GSH, see Bromosulfophthalein-gluta- slices, 902 lease, effects of beta adrenocep- thione conjugate Calver, A. L., see MacAllister, R. J., 154 tors in, in anesthetized dogs, 1337 Buccafusco, J. J., Lapp, C. A., Westbrooks, Calyculin A, toxicity of, 545 Catecholaminergic neuronal cells, voltage- K. L. and Ernsberger, P.: Role of Cameron, N. E., see Dines, K C., 49 activated potassium channels in, medullary 11-imidazoline and O2 cAMP, see Cyclic AMP kappa opioid receptor-mediated adrenergic receptors in the anti- Campbell, J. E., see Anderson, D. J., 1434 suppression of, 927 hypertensive responses evoked by Canet, E., see F#{233}l#{233}tou,M., 1071, 1078 Catecholamines central administration of clonidine Cannabinoid receptors, anandamide ana- preconditioning by, in rat hearts, 689 analogs in conscious spontaneously log binding, 1172 secretion in adrenal chromaffin cells, re- hypertensive rats, 1162 Cannabinoids, modulation of voltage- duction by ginseng sapomns, in Budinsky, R., see Grossman, S., 870 sensitive potassium A-current by, bovine, 629 Budzik, B., see Tracey, W. R., 1295 in hippocampal neurons, 734 Cations, renal transport, site-selective ef- Bueno, L., see Bonnafous, C. , 995; Botella, Canonero, R., see Martelli, A., 113 fect of bicarbonate on, 72 A., 1008 Canton, M., see Betancur, C., 1450 Caudate nucleus, [3H]WIN 35,428 binding Buprenorphine Canzoniero, L. M. T., see Lynch, J. J. III, in, in rabbit, 435 antagonism of mu opioids by, in rhesus 554 C57BL’6,J mice, dopamine agonist-induced monkey tail-withdrawal proce- Capolino, A. J., see Pendley, C. E., 1015 gnawing in, 7 dure, 1345 Capsaicin CD4 T cells, antiproliferative effects of intravenous, effects on C-fiber reflex, in dilation of arterioles and venules by, in opioids on, in mice, 1105 rat, 830 rat striated muscle, 605 CD8 T cells, antiproliferative effects of S Burke, T. J., see Koo, W.-S., 206 regulation ofjejunal arterioles by, in N. opioids on, in mice, 1105 Burman, M., see Barnette, M. S., 674, 1396 brasiliensis-sensitized rats, 337 Cederbaum, A. I., see Dai, Y., 1497 Burton, P. 5., see Chikhale, E. G., 298 Captopril, chronic effect in mu.rine dilated Cemerikic, B., Zamah, R. and Ahmed, M. Buserelin, pathways of degradation by S.: Opioid tolerance in human kidney membrane, in rat, 709 cardiomyopathy, comparison with losartan, 955 placenta due to in vitro metha- Butaprost, effects in colonic circular done administration, 987 Carbidopa, effects on peripheral L-dopa smooth muscle, in dog, 1008 Cephalosporins, intestinal transport, in pharmacokinetics, microdialysis Butler, A. M., see Martini, R., 427 human, rat and rabbit small in- study, in beagle dog, 1323 testines, 26 Carbocyclic nucleoside, enantiomeric ana- Cabral, G. A., see McCoy, K. L., 1216 Cerebral artery, perivascular nerves, argi- logues, TNF-a inhibition by, 1506 Cadet, J. L., see Silverthorn, M. L., 213 nine synthesis from citrulline in, 2l3-Carbomethoxy-3-(4-fluorophenyl)-N- Caffeine 895 [3H]methyltropane, see WIN effects on hippocampal acetylcholine re- Cerebral cortex 35,428 lease, 637 cholinesterase inhibitors and idazoxan effects on ventilation during nicotine ad- (-)-2-f3-Carbomethoxy-3-3-(4-fluorophenyl)- effects in, in rat, 230 tropane 1,5-napthalenedisulfon- ministration, in rhesus monkeys, dopamine release in, basal and stress- 1085 ate, see WIN 35,428 induced, modulation by abecarnil intravenous, subjective reports and 2-p-(2-Carboxyethyl)phenethylamino-5’- and imidazenil, in rat, 241 physiological effects in stimulant N-ethylcarboxamido-adenosine, membrane {3H]-glibenclamide binding, drug abusers, 351 see CGS-21680 displacement by glibenclamide Calcitonin gene-related peptide Cardiac cell membranes, cholesterol con- analogs, in rat, 778 receptor binding sites, effects of mor- tent, lovastatin effects on, in nor- C-fiber reflex, effects of intravenous mor- phine tolerance in, in rat spinal mal and cardiomyopathic ham- phine and buprenorphine on, in cord, 887 sters, 863 rat, 830 renal effects of, 56 Cardiomyopathy c-fos Calcitonin gene-related peptide-like im- dilated, chronic effect oflosartan vs cap- expression of, beta receptor induction of, munostaining, effects of mor- topril in, in murine model, 955 in rat brain, 415 1995 Index 1565

striatal expression, effects of repeated Chondrocytes, metalloprotease synthesis Clotrimazole, oral, blockade of human daily dopamine receptor agonist inhibitors on, identification of, erythrocyte Ca -activated K treatment on, 1483 1519 channels by, 266 [3H]CFT, see [3H]WIN 35,428 Chou, S. T., see Ng, C. Y., 1332 Co, C., see Hemby, S. E., 591, 656 CFTR, see Cystic fibrosis transmembrane Chrandasekhar, S., Harvey, A. K., Dell, C. Cocaine conductance regulator P., Ambler, S. J. and Smith, C. cardiovascular effects, monoamine up- cGMP, see Cyclic GMP W. : Identification of a novel take inhibition and local anesthe- CGP2O712A, effects in SNS-evoked adre- chemical series that blocks inter- sia in, in conscious rabbits, 128 nal catecholamine release, in leukin-i-stimulated rnetallopro- conditioned rewarding effects, sensitiza- anesthetized dogs, 1337 tease activity in chondrocytes, tion to, 808 CGRP, see Calcitonin gene-related peptide 1519 prenatal exposure CGS-21680, modulation of intraocular Christensen, S. B., see Barnette, M. S., effects on dopamine Gas coupling, 492 pressure by, in rabbits, 320 674, 1396 effects on mesocortical dopamine re- Chabot-Fletcher, M. C., Underwood, D. C., Christopher, T. A., Lopez, B. L., Yue, T.-L., lease, 1211 Breton,J.J.,Adams,J.L.,Kagey- Feuerstein, G. Z., Ruffolo, R. R., repeated administration of, effects on Sobotka, A., Griswold, D. E., Mar- Jr. and Ma, X.-L.: Carvedilol, a neuronal responses to glutamate shall, L. A., Sarau, H. M., Wink- new beta-adrenoreceptor blocker, in mesoaccumbens dopamine sys- ler, J. D. and Hay, D. W. P.: vasodilator and free-radical scav- tern, 445 Pharmacological characterization enger, exerts an anti-shock and self-administration and discrimination of SB 202235, a potent and selec- endothelial protective effect in rat of, role of delta opioid receptors tive 5-lipoxygenase inhibitor: Ef- splanchnic ischemia and reperfu- in, in rhesus monkeys, 1245 fects in models of allergic asthma, sion, 64 soluble binding, in primate striatum, 1147 Chromaffin cells, adrenal, ACh-evoked 1224 Challinor-Rogers, J. L., Kong, D. C. M., Iskander, M. N. and McPherson, Na influx and catecholamine se- tropane analog, effects on nucleus ac- G. A.: Structure-activity relation- cretion in, reduction by ginseng cumbens extracellular dopamine ship of glibenclamide analogs: A saponins, in bovine, 629 concentration and motor activity, comparison of potency as levcro- Chung, K. F., see Tsukagoshi, H., 1257 656 makalim antagonists in rat aorta Cicero, T. J., Nock, B., O’Connor, L., Cocaine hydrochloride, effects on nucleus vs. affinity for [3H1-glibenclamide Adams, M. and Meyer, E. R.: accumbens extracellular dopa- binding to membranes from rat Adverse effects of paternal opiate mine concentration and motor ac- cerebral cortex, 778 exposure on offspring develop- tivity, 656 Chatani, F., see Kim, S., 509 ment and sensitivity to mor- Coderre, T. J., see Pitcher, G. M., 1428 Chauvin, M., see Guirimand, F., 830 phine-induced analgesia, 386 Cognition deficits, benzodiazepine-in- Chen, F.-Y. and Lee, T. J.-F.: Arginine Cicletanine, renal effects duced, imidazenil reduction of, in synthesis from citrulline in clearance and micropunctures studies in monkeys, 1307 perivascular nerves of cerebral rats, 1190 Cohen, M. L., see Gidda, J. S., 695 artery, 895 role of renal prostaglandins and kinins Colletti, A. E., see Krieter, P. A., 816 Chen, Q., Yu, P., De Petris, G., Biancani, and muscarinic receptors in, 1197 Collier, J., see MacAllister, R. J., 154 P. and Behar, J.: Distinct musca- Cieslinski, L. B., see Barnette, M. S., 674, Colon rinic receptors and signal trans- 1396 circular muscle duction pathways in gallbladder Cingulate cortex, dopamine release, ef- bradkynin-evoked contraction of, 344 muscle, 650 fects of prenatal cocaine exposure PGE2 EP receptor effects in, in dog, Cheng, J. B., see Showell, H. J., 176 on, 1211 1008 Cheng, X.-M., see Reynolds, E. E., 1410 Circular smooth muscle FP receptor subtype radioligand binding Cheval, B., see Bril, A., 1264 colonic analysis, in rat, 285 Chikhale, E. G., Burton, P. 5. and Bor- bradkynin-evoked contraction of, 344 Colonic mucosa, ion transport in, ET- chardt, R. T. : The effect of vera- PGE2 EP receptor effects in, in dog, mediated, in rat, 1313 pamil on the transport of peptides 1008 Complement system, role in trimellitic an- across the blood-brain barrier in esophageal and lower esophageal hydride-induced allergic response rats: Kinetic evidence for an api- sphincter, signal transduction in lung, 793 cally polarized efflux mechanism, pathways in, in cat, 482 Compton, D. R., see Adams, I. B., 1172 298 Cisplatin, emesis induced by, 5-HT3 recep- Conditioning Childers, S., see Deadwyler, S. A., 734 tor antagonist effects against, in phenylephrine preconditioning, in rat Chloride channels dogs, 695 hearts, 689 cardiac CFTR, muscarinic regulation Citrulline, arginine synthesis from, in ce- place preference, sensitization to co- by quaternary ammonium corn- rebral perivascular nerves, 895 caine reward by, 808 pounds, 470 Clark, E., see Conklin, J. L., 762 Conger, L. K, see Ervin, G. N., 1203 dimethyl sulfoxide effects on, in guinea Clark, M. A., see Ludens, J. H., 1375 Conklin, J. L., Murray, J., Ledlow, A., pig ventricular preparations, Clearance study, of cicletanine effects on Clark, E., Hayek, B., Picken, H. 1273 kidney function, in rats, 1190 and Rosenthal, G.: Effects of re- Chlorzoxazone hydroxylation, cytochrome P-450 isozyme effects on, in rat Clonidine combinant human hemoglobin on liver microsomes, 1156 intratheca!, antinociceptive effects, me- motor functions of the opossum Choi, D. W., see Lynch, J. J. III, 554 diation by spinal nonadrenergic esophagus, 762 Cholecystokin-B receptors, RP 73870 an- imidazoline receptors, in rat, Conklyn, M. J., see Showell, H. J., 176 tagomst, anti-ulcer effects, in rat, 1057 Conney, A. H., see Stauber, K. L., 967 1015 supraspinal, antinociceptive effects, w-Conopeptides, blockade of voltage- Cholesterol, cardiac and RBC membrane NAC-3-END effects on mastopa- sensitive calcium channels by, at content, lovastatin effects on, in ran reduction of, in mice, 787 mouse neuromuscular junction, normal and cardiomyopathic Clonidine analogs, antihypertensive ef- 248 hamsters, 863 fects, rnedullary 11-imidazoline Contractility, urinary bladder, muscarinic Cholinesterase inhibitors, coadministra- and a2-adrenergic receptors in, in receptor subtypes mediating, 959 tion with idazoxan, effects in rat conscious spontaneously hyper- Convulsions, FPL 13950 effects against, cortex, 230 tensive rats, 1162 1023 1566 Index Vol. 273

Corpus striatum N6-Cyclohexyl-adenosine, modulation of Dazzi, L., Motzo, C., Imperato, A., Serra, c-los expression, effects of repeated daily intraocular pressure by, in rab- M., Gessa, G. L. and Biggio, G.: dopamine receptor agonist treat- bits, 320 Modulation of basal and stress- ment on, 1483 (± )-(Cyclohexyloxcarbony-loxy)ethyl2- induced release of acetylcholine MDMA-induced dopamine release in, ethoxy-1-[[2’-(1H-tetrazol-5-yl)bi- and dopamine in rat brain by abe- modulation by 5-HT/GABA inter- phenyl-4-yl]methyl]- 1H-benz- carnil and imidazeml, two anxio- actions in substantia nigra, 1063 imidazole-7-carboxylate, see TCV- selective -y-aminobutyric acidA re- muscarinic autoreceptor m2 subtype 116 ceptor modulators, 241 identification, in rat, 273 9-[( 1R,3R)-trans-Cyclopentan-3-ol}ad- Deadwyler, S. A., Hampson, R. E., Mu, J., opioid peptide levels, with thioacet- enine, see MDL 201,449 Whyte, A. and Childers, S.: Can- amide-induced fulminant hepatic 9-[(1R,3S)-cis-Cyclopentan-3-oljadenine, nabinoids modulate voltage sen- failure, in rats, 185 see MDL 201,451 sitive potassium A-current in hip- soluble [3H]WIN 35,428 binding in, in 9-[(1S,3R)-cis-Cyclopentan-3-ol]adenine, pocampal neurons via a cAMP- primate, 1224 see MDL 201,112 dependent process, 734 Cortical neurons, oxygen-glucose depriva- 9-[( 1S,3S)-trans-Cyclopentan-3-ol]ad- DeKrey, G. K and Kerkvliet, N. I.: Effects tion-induced injury, reduction by enine, see MDL 201,484 of exogenous corticosterone treat- sodium channel blockers in corn- N-Cyclopropylmethyl-5f3-methyl-14j3-(p- ment on alloantigen-specific cyto- bination with glutamate receptor nitrocinamoylamino)-7,8-dihy- toxic T lymphocyte activity in dromorphinone, prevention of antagonists, 554 mice, 823 morphine antinociceptive toler- Corticosterone Deleu, D., Sarre, S., Ebinger, G. and Mi- ance with, 680 exogenous, effects on alloantigen-spe- chotte, Y.: The effect of carbidopa Cystic fibrosis transmembrane conduc- cific CTL activity, in mice, 823 and entacapone pretreatment on tance regulator, cardiac C1 cur- modulation of 5-HT4 response by, in rat the L-dopa pharmacokinetics and rent, muscarinic regulation by CAl hippocampal pyramidal neu- metabolism in blood plasma and rons, 1132 quaternary ammonium corn- skeletal muscle in beagle dog: An Costa, E., see Thompson, D. M., 1307 pounds, 470 in vivo microdialysis study, 1323 Cotter, M. A., see Dines, K. C., 49 Cytochrome P450 Deleve, L. D., see Runnegar, M. T., 545 Coyne, K. S., see Nelson, S. D., 315 1A1 Dell, C. P., see Chrandasekhar, S., 1519 CP-105696, pharmacologic activity, 176 effects on chlorzoxazone hydroxyla- Delvaux, M., see Botella, A., 1008 Cressman, M. D., see Pogue, D. H., 863 tion, in rat liver microsomes, Dependence Criswell, H. E., Simson, P. E., Knapp, D. 1156 ethanol, effects on cerebral diazepam J., Devaud, L. L., McCown, T. J., epidermal, flow cytometry of, in mu- binding inhibitor mRNAlevels, in Duncan, G. E. , Morrow, A. L. and rime cells, 967 mice, 1529 Breese, G. R.: Effect of zolpidem 2E1 mu opiate, ontogency of, in rat, 1361 on y-aminobutyric acid (GABA)- effects on chlorzoxazone hydroxyla- opioid, dynorphin A modulation of, 292 induced inhibition predicts the tion, in rat liver microsomes, De Petris, G., see Chen, Q., 650 interaction of ethanol with GA.BA 1156 L-Deprenyl, protective effects against on individual neurons in several pulmonary, bioactivation of 1,1-di- MDMA rat brain regions, 526 chloroethylene by, in male and fe- 5-HT neurotoxicity, 667 Deprivation-induced feeding, effects of an- Crosby, G., see Billard, W., 273 male mice, 561 Crosson, C. E. : Adenosine receptor activa- transfected HepG2 cells, acetamino- orectic and aversive agents on, in rats, 1203 tion modulates intraocular pres- phen cytotoxicity in, in human, Dersch, C. M., see Silverthorn, sure in rabbits, 320 1497 M. L., 213 Cuadra, G. and Giacobini, E.: Coadminis- 3A, effects on chlorzoxazone hydroxyla- Devaud, L. L., see Criswell, H. E., 526 Development, adverse effects of paternal tration of cholinesterase inhibi- tion, in rat liver microsomes, opiates exposure tors and idazoxan: Effects of neu- 1156 on, 386 rotransmitters in rat cortex in 2Cii, pretranslation down regulation in Diabetics, effects of evening primrose oil vivo, 230 vitamin A deficiency, prevention on nerve conduction and blood CV-i808, modulation of intraocular pres- by ATRA, in male rat liver, 427 flow in, in rats, 49 sure by, in rabbits, 320 Cytotoxicity, acetaminophen, in human Diazepam binding inhibitor, cerebral Cyclic AMP CYP2E1-transfected HepG2 cells, mRNA levels, effects of ethanol cannabinoid modulation of voltage- 1497 dependence and withdrawal on, sensitive potassium A-currents Cytotoxic T lymphocytes, alloantigen- in mice, 1529 via, in hippocampal neurons, 734 specific activity, effects of exoge- 1,l-Dichloroethylene, bioactivation by pul- exogenous, metabolism to adenosine, in nous corticosterone on, in mice, monary CYP2E1, in male and fe- 823 rat kidney, 728 male mice, 561 induction by TSH, effects of antiar- Dahl#{233}n,S.-E., see Matsuda, H., 1182 Dihydrexidine, effects on ventral paffidal rhythmic drugs on, in thyroid Dai, Y. and Cederbaum, A. I.: Cytotox- neuronal activity, 516 cells, 702 icity of acetaminophen in human trans- 10, 1 1-Dihydroxy-5,6,6a,7,8, 12b- secretion by epithelial and fibroblast cytochrome P4502E1-transfected hexahydrobenzo[a}phenanthri- cells, effects of nitric oxide on, 16 HepG2 cells, 1497 dine, see Dihydrexidine Cyclic GMP DAMGO, locomotor effects in median ra- L-3,4-Dihydroxyphenylalanine, peripheral nitroglycerin-induced, tissue thiols con- phe nucleus, 327 pharmacokinetics, microdialysis tent and, in rats, 94 Danhof, M., see Math#{244}t,R. A. A., 405 study, in beagle dog, 1323 secretion by epithelial and fibroblast Dapsone Dilated cardiomyopathy, chronic effect of cells, effects of nitric oxide on, 16 hemolytic anemia induced by, 870 losartan vs captopril in, in mu- Cyclic GMP phosphodiesterase, inhibition hemotoxicity, in G6PD-deflcient eryth- rime model, 955 of, modulation of ANP-dependent rocytes, in rat, 870 l-(2,5-Dimethoxy-4 iodophenyl)-2-amino- endothelin effects by, 744 Das, D. K., see Tosaki, A., 689 propane, head-twitches induced Cyclic guanosine monophosphate, see Cy- Davidson, A., see Gozes, I., 161 by, mediation by 5-HT recep- clic GMP Davies, H. M. L., see Hemby, S. E., 656 tors, in rat, 101 3-Cyclodextrin tetradecasulfate, inhibi- Davies, M. F., see Maguire, P. A., 842 N-(3,4-Dimethoxyphenyl)-N-[3[[2-(3,4- tion of human vascular smooth Davis, M. A., see Pendley, C. E., 1015 dimethoxyphenyl)ethyl]propyl]- muscle cell migration and prolif- Davis, P., see Bilsky, E. J., 359 4-nitrobenzamide hydrochloride, eration by, 948 Davison, S., see Mathison, R., 337 see BRL-32872 1995 Index 1567

Dimethyl sulfoxide, effects on action p0- D2 Electrolyte excretion, effects of K chan- tentials, ionic currents and cell agonist effects on schedule-controlled nel blocker on, in conscious rats, water, in guinea pig ventricular behavior, in squirrel monkeys, 40 1375 preparations, 1273 agonist effects on scratching, in squir- Electrophysiology, effects of procainamide Dines, K C., Cameron, N. E. and Cotter, rel monkeys, 138 and N-acetylprocainamide on, ef- M. A.: Comparison of the effects agonists, repeated daily, effects on ro- fects of infarct healing on, 315 of evening primrose oil and trig- tation and striatal c-fos expres- Elhawary, A. M. and Pang, C. C. Y.: Renal lycerides containing y-linolenic sion, 1483 vascular and tubular actions of acid on nerve conduction and effects in activity stress gastric le- calcitonin gene-related peptide: blood flow in diabetic rats, 49 sions, in rats, 1001 Effect of NGnitroLarginine LY 165,163 antagonist effects at, 1418 methyl ester, 56 Dipeptides, intestinal transport, in rat, D3, LY 165,163 antagonist effects at, Elliott, W. C. and Patchin, D. S.: Effects rabbit and human small intes- 1418 and interactions of gentamicin, tines, 26 direct vs indirect agonist gnawing, in polyaspartic acid and diuretics on p-(Dipropylsulfamoyl)benzoic acid, see C57BIJ6J mice, 7 urine calcium concentration, 280 Probenecid Dopaminergic neurons Ellis, D. M., see Maguire, P. A., 842 Disch, C. H., see Pogue, D. H., 863 modulation by 5-HTIA receptors, in rat, Emesis, cisplatin-induced, 5-HT3 receptor 14a,14’f3-[Dithiobis[(2-oxo-2,i-ethanediyl)- 1032 antagonist effects against, in iminoj]bix-7,8-dihydro-N-(cyclo- ventral tegmental area, serotonin poten- dogs, 695 propylmethyl)normorphinone, pro- tiation of ethanol excitation of, in Enantiomeric carbocyclic nucleoside ana- vention of morphine antinocicep- rat brain slices, 1139 logues, TNF-a inhibition by, 1506 tive tolerance with, 680 Dopamine transporter f3-Endorphin, brain and plasma levels, Diuretics [3H]WIN 35,428 binding site on, in rab- with thioacetamide-induced ful- effects and interactions with gentamicin bit, 435 minant hepatic failure, in rats, and polyaspartic acid on urine solubilized, [3H]WIN 35,428 binding, in 185 calcium concentration, 280 primate striatum, 1224 Endothelin-3, ANP-dependent effects, effects ofnovel potassium channel block- DPDPE, locomotor effects in median raphe modulation by inhibitors of neu- ers on, 1382 nucleus, 327 tral endopeptidase and cGMP- DMSO, see Dimethyl sulfoxide D-Pen2,D-Pen5-enkephalin, see DPDPE PDE, 744 Doherty, A. M., see Reynolds, E. E., 1410 Drake, R. R., see Little, J. M., 1551 Endothelin-1, effects on mesangial cell Doherty, N. S., see Showell, H. J., 176 Drop, L. J., see Kaufmann, M. A., 855 proliferation and handling of IgG DOI, see 1-(2,5-Dimethoxy-4 iodophenyl)- Drug abusers, intravenous caffeine in, complexes, heparin modulation 2-aminopropane subjective reports and physiolog- of, 80 Donevan, S. D., see Subramaniam, S., 878 ical effects, 351 EndothelinA receptors L-Dopa, see L-3,4-Dihydroxyphenylalanme Drug clearance, hepatic, effects of right FR139317 antagonist, mediation of co- Dopamine heart failure on, in rats, 1332 lonic ion transport by, in rat, 1313 adenosine effects on, in midbrain, 576 Drug discrimination, cocaine, role of delta PD156707 antagonist pharmacology, basal and stress-induced release, modu- opioid receptors in, in rhesus 1410 lation by abecarnil and imidaze- monkeys, 1245 EndothelinB receptors nil, in rat brain, 241 Dubroeucq, M.-C., see Pendley, C. E., 1015 activation of, effects on basilar artery, 1 endogenous, role in D1 agonist-induced Duncan, G. E., see Criswell, H. E., 526 IRL162O agonist, mediation of colonic effects in ventral pallidal neuro- Dunlow, L. D., see Welch, S. P., 1235 ion transport by, in rat, 1313 Dworkin, S. I., see Hemby, S. E., 591, 656 nal activity, 516 Endothelins, mediation of colonic ion low brain, promotion of alcohol abuse Dynorphin A transport by, in rat, 1313 brain and plasma levels, with thioacet- by, 373 Endothelium, carvedilol effects on, in SAO amide-induced fulminant hepatic MDMA-induced striatal release, modu- shock in, in rat, 64 failure, in rats, 185 lation by 5-HT/GABA interac- Endothelium-derived relaxing factor, inhi- locomotor effects in median raphe nu- bition of, nitric oxide dose-re- tions in substantia nigra, 1063 cleus, 327 mesoaccumbens system, responses to sponse study in isolated perfused modulation of opioid effects by, 292 rat kidney after, 855 glutamate, effects of repeated co- Dynorphin A-(2-17), naloxone-insensitive Endotoxic shock, in vivo animal models, S caine on, 445 antinociceptive effects, in writh- 16118 effects in, 1078 mesocortical release, effects of prenatal ing assay, 802 Endotoxin, hypotension and mortality in- cocaine exposure on, 1211 duced by, hydroxocobalamin ef- nucleus accumbens extracellular con- Ear artery, adrenergic nerves on, facilita- fects against, in rodents, 257 centrations tory prejunctional purinoceptors Engelman, D. T., see Tosaki, A., 689 effects of intravenous heroin on, by on, in rabbit, 1390 Engelman, R. M., see Tosaki, A., 689 microdialysis, 591 Ebinger, G., see Deleu, D., 1323 Enprostil, effects in colonic circular effects of Prrrr vs cocaine HC1 on, 656 Ecstasy, see 3,4-Methylenedioxymetham- smooth muscle, in dog, 1008 Dopamine receptors phetamine Entacapone, effects on peripheral L-dopa D1 Edmunds, J. J., see Reynolds, E. E., 1410 pharmacokinetics, microdialysis agonist effects on schedule-controlled EDRF, see Endothelium-derived relaxing study, in beagle dog, 1323 behavior, in squirrel monkeys, 40 factor Eosinophils agonist effects on ventral pallidal neu- Edwards, C. K. III, see Bradshaw, M., beta adrenergic inhibition of, blockade ronal activity, 516 1506 by salmeterol, 850 agonists, repeated daily, effects on ro- Eisenstein, T. K., see Belkowski, S. M., superoxide production in, suppression tation and striatal c-fos expres- 1491 by PDE N inhibitors, in guinea sion, 1483 Eison, A. S., Freeman, R. P., Guss, V. B., pig, 674 antagonist modulation of DOI-in- Mullins, U. L. and Wright, R. N.: Epiandrosterone, inhibition of G6PD by, duced head-twitches in rat, 101 Melatonin agonists modulate in rat erythrocytes, 870 effects in activity stress gastric le- 5-HT2A receptor-mediated neuro- Epidermal cells, CYP1A1-containing, flow sions, in rats, 1001 transmission: Behavioral and bio- cytometry of, in mice, 967 Gas coupling, effects of prenatal co- chemical studies in the rat, 304 Epithelial cells, LLC-PK1, secretion of caine on, 492 Elderly persons, enantioselective disposi- cAMP and cGMP by, effects of ni- LY 165,163 antagonist effects at, 1418 tion of ibuprofen in, 88 tric oxide on, 16 1568 Index Vol. 273

EP receptors, subtype effects in colonic cir- Extracellular matrix proteins, gene ex- Forkert, P.-G., see Lee, R. P., 561 cular smooth muscle, in dog, 1008 pression of, AT1 receptor antago- Forskolin, effects on secretion of cAMP Erdbrugger, W., Raulf, M., Otto, T. and nist effects on, in cardiac and vas- and cGMP by epithelial and fibro- Michel, M. C.: Does [3H]2-me- cular tissues ofhypertensive rats, blast cells, 16 thoxy-idazoxan (RX 821002) de- 509 Fourier-derived affinity spectrum analy- tect more alpha-2-adrenoceptor sis, and LIGA.ND, resolution of Fairbairn, C. E., see Woodward, D. F., 285 benzodiazepine receptor hetero- agonist high-affinity sites than Faivre, J.-F., see Bril, A., 1264 geneity in rat spinal cord with, [3H]rauwolscine? A comparison of Fan, T., see George, S. R., 373 842 nine tissues and cell lines, 1287 Faraci, F. M., see Kitazono, T., 1 FPL 13950, anticonvulsant efficacy/safety Erick, J., see Jayyosi, Z., 1156 Farrell, C. A., see Showell, H. J., 176 properties of, 1023 Ernsberger, P. , see Buccafusco, J. J., 1162 FASA, see Fourier-derived affinity spec- FP receptors, subtypes, radioligand bind- Ervin, G. N., Birkemo, L. S., Johnson, M. trum analysis F., Conger, L. K., Mosher, J. T. ing analysis, 285 Fauch#{233}re, J.-L., see F#{233}l#{233}tou,M., 1071, FR139317, mediation of colonic ion trans- and Menius, J. A., Jr.: The effects 1078 port by, in rat, 1313 of anorectic and aversive agents Feeding, deprivation-induced, effects of Fraser, D.G., Regal, J. F. and Arndt, M. L.: on deprivation-induced feeding anorectic and aversive agents on, and taste aversion conditioning in Trimellitic anhydride-induced al- in rats, 1203 lergic response in the lung: Role rats, 1203 Felbamate, NMDA receptor blockade by, of the complement system in cel- Erythrocytes 878 lular changes, 793 Ca4 k-activated K channels in, block- Feldman, P. D. : Neurokinin 1 receptor me- Freeman, R. P., see Eison, A. S., 304 ade by oral clotrimazole, in hu- diation of the vasodepressor ef- Frexinos, J., see Botella, A., 1008 man, 266 fects of substance P in the nu- Fridkin, M., see Gozes, I., 161 G6PD-deficient, dapsone hernotoxicity cleus ofthe tractus solitarius, 617 Friedman, E., see Wang, H.-Y., 492 in, in rat, 870 F#{233}l#{233}tou,M., Lonchampt, M., Robineau, P., Friedman, E., see Wang, Y.-Y., 1211 membrane cholesterol content, lovasta- Jammoneau, I. , Thurieau, C., Frontal cortex, dopamine release, effects tin effects on, in normal and car- Fauch#{233}re, J.-L., Villa, P., Ghezzi, of prenatal cocaine exposure on, P., Prost, J.-F. and Canet, E.: diomyopathic hamsters, 863 1211 Escherichia coli endotoxin lipopolysaccha- Effects of the bradykiin B2 an- -Funaltrexamine tagonist S 161 18 (p-guanidoben- ride, hypotension and mortality intracerebroventricular, effects on opi- zoyl-[Hyp3,Thi5,D-Tic7,Oic8}- induced by, hydroxocobalamin ef- oid receptor binding, in rat brain, fects against, in rodents, 257 bradykinin) in different in vivo 1047 animal models of inflammation, Escobar, M. R. and Sitar, D. S.: Site- prevention of morphine antinociceptive 1078 selective effect of bicarbonate on tolerance with, 680 F#{233}!#{233}tou,M., Robineau, P., Lonchampt, amantadine renal transport: Qui- Furukawa, K-I., see Ohkura, M., 934 nine-sensitive in proximal vs M., Bonnardel, E., Thurieau, C., quinidine-sensitive sites in distal Fauch#{232}re, J.-L., Widdowson, P., Gaginella, T. S., see Hasler, W. L., 344 tubules, 72 Mahieu, J.-P., Serkiz, B., Volland, Gainey, D., see McCoy, K L., 1216 Esophageal circular smooth muscle, signal J.-P. , Martin, C., Naline, E., Gallbladder muscle, muscarimc receptor transduction pathways in, in cat, Advenier, C., Prost, J.-F. and subtypes and signal transduction 482 Canet, E.: S 16118 (p-guanido- pathways in, 650 Esophagus, motor functions, effects of re- benzoyl-[Hyp3,Thi5,D-Tic7,Oic8]- Gang, J.-M., see Liu, Q.-Y., 32 combinant human hemoglobin bradykinin), is a potent and long- Gantz, I., see Miwa, H., 367 on, in opossum, 762 acting bradykinin B2 receptor an- Gardner, D. G., see Valentin, J.-P., 744 Esterline, N. J., see Pendley, C. E., 1015 tagonist, in vitro and in vivo, 1071 Gardos channels, erythrocyte, blockade by oral clotrimazole, 266 Estradiol 17 /3, inhibition of contraction of d-Fenfluramine, 5-HT release and hypo- phagia induced by, 643 Garske, G. E., see Palmer, G. C., 1023 aorta by, in rat, 1544 Feng, H., see Hasler, W. L., 344 Garz#{243}n,J., see S#{225}nchez-Blazquez, P., 787 ET, see Endothelin Fetus, cocaine exposure, 492, 1211 Gastric emptying disturbances, benzo- Ethanol Feuerstein, G. Z., see Christopher, T. A., diazepine-withdrawal-induced, in acute, effects on cerebral diazepam 64; Yue, T.-L., 1442 rats, 995 binding inhibitor mRNA levels, in Fibroblast cells, RFL-6, secretion of cAMP Gastric glands, acid secretion, effects of mice, 1529 and cGMP by, effects of nitric ox- PDE N inhibitors on, in rabbit, chronic, effects on cerebral diazepam ide on, 16 1396 binding inhibitor mRNA levels, in Fielding, R. P., see Subramaniam, S., 878 Gastric lesions mice, 1529 Fink, G. D., see Gorbea-Oppliger, V. J., 611 activity stress, dopamine Dl and D2 re- excitation of ventral tegmental area Finley, D. K, see Zhou, L.-X., 121 ceptor effects in, in rats, 1001 neurons by, serotonin potentia- Fioramonti, J., see Botella, A., 1008 HP 73870 effects against, in rat, 1015 tion of, in rat brain slices, 1139 Fitzpatrick, L. R., see Pendley, C. E., 1015 Gastric motility, effects of serotonin.PFRH interaction with GABA, prediction by Flores, P., see Pel#{243}n,R., 138 microinjection into nucleus raphe zolpidern effects on GABA-in- Flow cytometry, of epidermal CYP1A1, in obscurus on, in rat, 499 duced inhibition, in rat brain re- murine cells, 967 Gastrin/cholecystokin-B receptors, RP gions, 526 Fluoroanandamide 73870 antagonist anti-ulcer ef- liver damage induced by, effects of vita- antinociceptive effects, in mice, 1235 fects, in rat, 1015 mm E supplementation on, 455 9-THC cross-tolerance, in mice, 1235 Ge, Y.-Z., see Morrison, S. F., 380 Etonitazene, antinociceptive effects in Flynn, M. A., see Reynolds, E. E., 1410 Gehret, J. R., see Wallace, A. A., 168 tail-withdrawal procedure, bu- Foot-shock stress, hippocampal acetylcho- Gengaro, P. E., see Koo, W.-S., 206 prenorphine antagonism of, in line and cortical dopamine re- Genotoxicity, hydralazine, testing of, 113 rhesus monkey, 1345 lease induced by, modulation by Gentamicin Evans, D. C., see Gidda, J. S., 695 abecarnil and imidazenil, in rat, calciuresis mediated by, 280 Evening primrose oil, effects on nerve con- 241 effects and interactions with polyaspar- duction and blood flow in diabetic Forebrain, zif/268 and preprodynorphin tic acid and diuretics on urine cal- rats, 49 mRNA expression in, dose-re- cium concentration, 280 EXP 3174, cerebroventricular, effects on lated effects of amphetamine or George, S. R., Fan, T., Ng, G. YK, Jung, S. ANG Il-induced hypertension, methamphetamine on, in rat, 909 Y., O’Dowd, B. F. and Naranjo, C. 611 Forest, M.-C., see Bril, A., 1264 A. : Low endogenous dopamine 1995 Index 1569

function in brain predisposes to tion by kidney membrane, in rat, phine on a C-fiber reflex in the high alcohol preference and con- 709 rat, 830 sumption: Reversal by increasing Gorbea-Oppliger, V. J. and Fink, G. D.: Gullikson, G. W., Loeffler, R. F., Mehrotra, synaptic dopamine, 373 Cerebroventricular injection of D. V., Casler, J. J., Bianchi, R. G., Gessa, G. L., see Dazzi, L., 241 angiotensin II antagonist: Effects Schmidt, R. E., Khoshaba, N. and Ghabrial, H., see Ng, C. Y., 1332 on blood pressure responses to Perkins, W. E.: Polymeric deliv- GHB, see y-Hydroxybutyric acid central and systemic angiotensin ery of the active isomer of miso- Ghezzi, P., see F#{233}l#{233}tou,M., 1078 II, 611 prostol reduces systemic avail- Ghia, M., see Martelli, A., 113 Gould, D. J., see Hill, C. E., 918 ability and uterotonic activity, Giacobini, E., see Cuadra, G., 230 Gout, B., see Bril, A., 1264 1123 Gidda, J. S., Evans, D. C., Cohen, M. L., Govindarajan, S., see Runnegar, M. T., 545 Gully, D., see Betancur, C., 1450 Wong, D. T., Robertson, D. W. Gozes, I., Lilling, G., Glazer, R., Ticher, A., Guss, V. B., see Eison, A. S., 304 and Parli, C. J.: Antagonism of Ashkenazi, I. E., Davidson, A., Guyenet, P. G., see Baraban, S. C., 927 serotonin type 3 receptors within Rubinraut, S., Fridkin, M. and Guyon, C., see Pendley, C. E., 1015 Brenneman, D. E. : Superactive li- the blood-brain barrier prevents Ha, J.-H., see Yurdaydin, C., 185 pophilic peptides discriminate cisplatin-induced emesis in dogs, Hackman, B. C., see Showell, H. J., 176 multiple vasoactive intestinal 695 Haddad, E.-B., see Tsukagoshi, H., 1257 peptide receptors, 161 Giebisch, G., see Wang, T., 1382 Haleen, S. J., see Reynolds, E. E., 1410 G6PD, see Glucose-6-phosphate dehydro- Ginseng saponins, reduction of ACh- Hall, S. D., see Rudy, A. C., 88 genase evoked Na influx and catechol- Hamaguchi, A., see Kim, S., 509 G proteins amine secretion by, in bovine ad- Hamilton, M. G. and Lundy, P. M.: Effect renal chromaffin cells, 629 inhibition by antiarrhythmic drugs, in of ruthenium red on voltage- thyroid cells, 702 Glazer, R., see Gozes, I., 161 sensitive Ca channels, 940 [3H]-Glibenclamide, binding to cerebral striatal, a-subunit, dopamine coupling, Hampson, R. E., see Deadwyler, S. A., 734 effects of prenatal cocaine on, 492 cortex membranes, displacement Han, B., see Sohn, U. D., 482 Gracz, L. M. and Madras, B. K: [3H]WIN by glibenclamide analogs, in rat, Han, C., see Thomas, G., 1544 35,428 ([3H]CFT) binds to multi- 778 Harris, E. W., see Palmer, G. C., 1023 ple charge-states of the solubi- Glibenclamide analogs, structure-activity Harris, R., see Tracey, W. R., 1295 lized dopamine transporter in pri- relationship, 778 Harvey, A. K. , see Chrandasekhar, S., mate striatum, 1224 Glomerular filtration rate, effects of K 1519 Gramicidin, immunosuppression by, in channel blocker on, in conscious Harvey, J. A., see Aloyo, V. J., 435 rat, 223 rats, 1375 Harvey, R. D., see Zakharov, S. I., 470 Granulocyte colony-stimulating factor, Glomerular mesangial cells, proliferation Hashimoto, T., see Ishii, R., 1390 nartograstim derivative, tissue and handling of IgG complexes Hasler, W. L., Kurosawa, S., Takahashi, uptake of, in rats, 1114 by, heparin effects on, 80 T., Feng, H., Gaginella, T. S. and Grassl, S. M., see Makhuli, M. J., 146 Glucose-6-phosphate dehydrogenase, epi- Owyang, C.: Bradykinin acting on Greenberg, S. S., Xie, J., Zatarain, J. M., androsterone inhibition of, in rat B2 receptors contracts colon circu- Kapusta, D. R. and Miller, M. J. erythrocytes, 870 lar muscle cells by 1P3 generation S.: Hydroxocobalamin (vitamin Glucose-6-phosphate dehydrogenase defi- and adenylate cyclase inhibition, B12a) prevents and reverses en- ciency, dapsone hemotoxicity in, 344 dotoxin-induced hypotension and in rat erythrocytes, 870 Hassell, A. E., see Zhou, L.-X., 121 mortality in rodents: Role of nitric Glucuronidation Hay, D. W. P., see Chabot-Fletcher, M. C., oxide, 257 1147 losartan, in rat intestine, 816 Greven, J.: Effects ofcicletanine on kidney Hayashi, M., see Takeo, S., 1403 thyroxine, UDP-glucuronosyltransfer- function 1. Clearance and mi- ase inducer effects on, in rats, 977 Hayek, B., see Conklin, J. L., 762 cropuncture studies in anesthe- Hay-Yehia, A. I. and Benet, L. Z.: Dissoci- Glutamate tized rats, 1190 ation of tissue thiols content from mesoaccumbens dopamine system re- Greven, J., Rahn, A. and Br#{228}ndle,E.: Ef- nitroglycerin-induced cyclic-3’,S’- sponses, effects of repeated co- fects of cicletanine on kidney guanosine monophosphate and caine on, 445 function 2. Role of renal prostag- the state of tolerance: In vivo ex- presynaptic GHB and GABAB receptor- landins and kinins, and of musca- periments in rats, 94 mediated release of, in rat tha- rinic receptors, 1197 He, L., see Hooke, L. P., 292, 802 lamic ventrobasal nucleus, 1534 Griffith, R. C., see Palmer, G. C., 1023 Head shakes/twitches receptor antagonists, in combination Griffiths, R. R., see Rush, C. R., 351 mediation by 5-HT2A receptors, in rat, with sodium channel blockers, re- Griswold, D. E., see Chabot-Fletcher, M. 101 duction of oxygen-glucose depri- C., 1147 mediation by melatonin agonists, in rat, vation-induced cortical neuronal Grossman, S., Budinsky, R. and Jollow, 304 injury by, 554 D.: Dapsone-induced hemolytic Heart GM-109, motilin antagonist properties, in anemia: Role of glucose-6-phos- allografts, gramicidin prolongation of rabbit small intestine smooth phate dehydrogenase in the he- survival, in rat, 223 muscle, 624 molytic response of rat erythro- AT1 receptor antagonist effects on gene Gnawing, dopamine agonist-induced, in cytes to N-hydroxydapsone, 870 expression of TGF-pl and extra- C57BIJ6J mice, 7 Grous, M., see Barnette, M. S., 1396 cellular matrix in, in hyperten- Gobert, A., see Millan, M. J., 1418 GTP, see Guanosine triphosphate sive rats, 509 Gobert, A., see Schreiber, R., 101 Gu, J.-L., see Yue, T.-L., 1442 phenylephrine-induced preconditioning Gobert, A, Lejeune, F., Rivet, J.-M., Audi- p-Guathdobenzoyl-[Hyp3,Thi5,D-Tic7,Oic8]- in, in rat, 689 not, V., Newman-Tancredi, A. and bradykinin, see 516118 Heart failure, right, effects on hepatic oxy- Milan, M. J.: Modulation ofthe ac- Guanosine triphosphate, binding proteins, genation and theophylline clear- tivity ofcentral serotoninergic neu- coupling to, muscariic receptor ance, in rats, 1332 runs by novel serntonin receptor subtypes mediating, 959 Hedqvist, P., see Matsuda, H., 1182 agonists and antagonists: A corn- Gudelsky, G. k, see Yamamoto, B. K, 1063 Heidbreder, Ch., see Shippenberg, T. S., panson to adrenergic and dopa- Guidotti, A., see Thompson, D. M., 1307 808 minergic neurons in rats, 1032 Guirimand, F., Chauvin, M., Willer, J.-C. Heidenreich, B. A., Mailman, R. B., Nichols, Gonadotropin-releasing hormone, busere- and Le Bars, D.: Effects of intra- D. E. and Napier, T. C.: Partial and lin analog, pathways of degrada- venous morphine and buprenor- full dopamine D1 agonists produce I 570 Index Vol. 273

comparable increases in ventral Hirai, S., see Yoshida, A., 702 CAl hippocampal pyramidal neu- pallidal neuronal activity: Contri- Hirano, T., Oka, K. and Tamaki, T.: Gram- rons, 1132 bution of endogenous dopamine, icidin as a potential immunosup- Hypertension 516 pressant for organ transplants- ANG Il-induced, effects of cerebroven- Heistad, D. D., see Kitazono, T., 1 tion: Suppression of human tricular EXP 3174 on, 611 Hemby, S. E., Co, C., Reboussin, D., Davies, lymphocyte blastogenesis in vitro AT1 receptor antagonist effects on gene H. M. L., Dworkin, S. I. and Smith, and prolongation of heart al- expression of TGF-131 and extra- J. E.: Comparison of a novel tro- lograft survival in the rat, 223 cellular matrix, in cardiac and pane analog of cocaine, 2f3-pro- Hisatome, I., see Yoshida, A., 702 vascular tissues of rats, 509 panoyl-3f3-(4-tolyl) tropane with Hodges, J. C., see Panek, R. L., 753 clonidine analog effects against, medul- cocaine HC1 in rats: Nucleus ac- Hoeper, B. J., see Bradshaw, M., 1506 lary 11-imidazoline and a2-adren- cumbens extracellular dopamine Hoffman, B. B., see Bowersox, S. S., 248 ergic receptors in, in conscious concentration and motor activity, Holtzman, J. L., see Zhou, L.-X., 121 spontaneously hypertensive rats, 656 Hooke, L. P., He, L. and Lee, N. M.: [Des- 1162 Hemby, S. E., Martin, T. J., Co, C., Dwor- Tyr]Dynorphin A-(2-17) has nal- genetic, renal effects of Ang II in, in kin, S. I. and Smith, J. E.: The oxone-insensitive antinociceptive young genetically hypertensive effects of intravenous heroin ad- effect in the writhing assay, 802 rats, 768 ministration on extracellular nu- Hooke, L. P., He, L. and Lee, N. M.: Dynor- spontaneous cleus accumbens dopamine con- phin A modulates acute and medullary 11-imidazoline and a2- centrations as determined by in chronic opioid effects, 292 adrenergic receptors effects in, in conscious rats, 1162 vivo microdialysis, 591 Hornby, P. J., see Krowicki, Z. K, 499 renal effects of Ang II in, in young Hemoglobin, recombinant human, effects Hosokawa, M., Tsukada, H., Ueda, S., genetically hypertensive rats, 768 on esophageal motor functions, in Sakai, M., Okuma, M., Oda, K, Hypophagia, induced by d-fenfluramine, opossum, 762 Takimoto, M., Okada, T. and 643 Hemolytic anemia, dapsone-induced, 870 Urade, Y.: Regulation of ion Hypotension, endotoxin-induced, hydroxo- Hemotoxicity, dapsone, in G6PD-deficient transport by endothelins in rat cobalamin effects against, in ro- erythrocytes, in rat, 870 colonic mucosa: Effects of an ETA Henry, J. L., see Pitcher, G. M., 1428 dents, 257 antagonist (FR139317) and an Heparin, effects on mesangial cell prolifer- ETB agonist (1RL1620), 1313 R-Ibuprofen, disposition in elderly per- ation and handling of IgG corn- Howell, L. L.: Effects of caffeine on venti- sons, 88 plexes, 80 lation during acute and chronic S-Ibuprofen, disposition in elderly per- Hepatic blood flow, effects of right heart nicotine administration in rhesus sons, 88 failure on, in rats, 1332 monkeys, 1085 Ibuprofen, enantioselective disposition in Hepatic failure, thioacetamide-induced Hozakowska, E., see Okada, S. S., 948 elderly persons, 88 fulminant, opioid peptide brain 15-HPETE, see 15(S)-Hydroperoxyeicosa- IC1118551, effects in SNS-evoked adrenal and plasma levels with, in rats, tetraenoic catecholamine release, in anes- 185 Hruby, V. J., see Bilsky, E. J., 359 thetized dogs, 1337 Hepatic oxygen delivery, effects of right 5-HT, see Serotonin Idazoxan, coadministration with cholines- heart failure on, in rats, 1332 Hu, X.-T., see White, F. J., 445 terase inhibitors, effects in rat Hepatotoxicity, protein phosphatase in- Huerter, C. J., see Kudlacek, P. E., 582 cortex, 230 hibitor, 545 Human liver, UDP-glycosyltransferases Ijzerman, A. P., see Math#{244}t,R. A. A., 405 HepG2 cells, human CYP2E1-transfected, from, characterization of, with Ikuta, M., see Takanashi, H., 624 acetaminophen cytotoxicity in, photoaffinity analogs, 1551 Iloprost, effects in colonic circular smooth 1497 Humphreys, M. H., see Valentin, J.-P., 744 muscle, in dog, 1008 Heroin, intravenous, effects on extracellu- Imai, S., see Kanda, T., 955 lar nucleus accumbens dopamine Hwang, 0., see Reynolds, E. E., 1410 Hydralazine, genotoxicity testing, 113 Imidazenil concentrations, by microdialysis, modulation of basal and stress-induced i5(S)-Hydroperoxyeicosatetraenoic, phar- 591 release of acetylcholine and dopa- macodynamics, in isolated arter- 15-HETE, see 15(S)-Hydroxyeicosatetrae- mine in rat brain by, 241 ies from guinea pig, rabbit, rat noic acid reduction of benzodiazepine-induced and human, 1182 Higashida, H., see Tamai, I., 26 cognition deficit by, in monkeys, Hydroxocobalamin, effects against endo- Hill, C. E. and Gould, D. J.: Modulation of 1307 toxin-induced hypotension and sympathetic vasoconstriction by Imidazoline receptors mortality, in rodents, 257 sensory nerves and nitric oxide in Ii, medullary, effects in conscious spon- -y-Hydroxybutyric acid, absence seizures rat irideal arterioles, 918 taneously hypertensive rats, 1162 induced by, endogenous GABA in, Hingorani, G. P., see Showell, H. J., 176 spinal nonadrenergic, mediation of in- Hippocampus in rat, 1534 trathecal clonidine antinocicep- N-Hydroxydapsone, hemotoxicity, in acetylcholine release in tion by, in rat, 1057 basal and stress-induced, modulation G6PD-deficient erythrocytes, in Immunoglobin G complexes, mesangial by abecarnil and imidazenil, in rat, 870 cell handling of, heparin effects rat, 241 (5)-N-Hydroxy-N-(2,3-dihydro-6-phenyl- on, 80 caffeine effects on, 637 methoxy-3-benzyofuranyl)urea, Immunostaining, CGRP-like, effects of CAl pyramidal neurons, corticosterone see SB 202235 morphine tolerance in, in rat api- modulation of 5-HT4 response in, 6-Hydroxydopamine, developmental ef- nal cord, 887 in rat, 1132 fects, in rat brain, 415 Immunosuppression long-term slices, induction of calpain- 15(S)-Hydroxyeicosatetraenoic acid, phar- of alloantigen-specific CTL, by exoge- mediated spectrin fragments by macodynamics, in isolated arter- nous corticosterone, in mice, 823 pathogenic treatments in, 902 ies from guinea pig, rabbit, rat gramicidin, in rat, 223 nicotinic acetylcholine receptors in, lead and human, 1182 Imperato, A., see Dazzi, L., 241 effects on, in rat, 1471 Hydroxylation, chlorzoxazone, cytochrome Inada, Y., see Kim, S., 509 NMDA receptors in, lead effects on, in P-450 isozyme effects on, in rat Inflammation rat, 1459 liver microsomes, 1156 acute, activated protein C effects voltage-sensitive potassium A-currents 5-Hydroxytryptamine, see Serotonin against, in rat models, 193 in, cannabinoid modulation of, Hyperpolarization, 5-HT4 response, corti- carrageenan-induced pleurisy, L-NMA 734 costerone modulation of, in rat reduction of, in rat, 1295 1995 Index 1571

in vivo animal models, S 16118 effects Isoproterenol, effects in SNS-evoked ad- Kerkvliet, N. I., see DeKrey, G. K, 823 in, 1078 renal catecholamine release, in Kertscher, U., Brudel, M., Mehlis, B., San- Inhalational anesthetics, effects on nitric anesthetized dogs, 1337 dow, J. and Berger, H.: Pathways oxide synthase, 599 Isradipine, interaction with lovastatin, in of degradation of buserelin by rat Inhibitory postsynaptic current, GABAB- normal, female and male volun- kidney membrane, 709 mediated, presynaptic inhibition teers, 121 Khettry, U., see Sadrzadeh, S. M. H., 455 by adenosine, in midbrain dopa- Ito, K., see Thomas, G., 1544 Khoshaba, N., see Gullikson, G. W., 1123 mine neurons, 576 Iwao, H., see Kim, S., 509 Kidney, see also under Renal 1D-myo-Inositol 1,2,6-trisphosphate, see bromosulfophthalein-glutathione conju- [3Hja-Trinositol Jackson, E. K, see Mi, Z., 728 gate disposition in, in rat, 1300 Inositol trisphosphate, bradykinin genera- Jackson, E. K., see Vyas, S. J., 768 cicletanine effects on tion of, colon contraction evoked Jakubowska, A., see Pendley, C. E., 1015 clearance and micropuncture studies by, 344 Jammoneau, I., see F#{233}l#{233}tou,M., 1078 in rats, 1190 Interleukin-i Jayyosi, Z., Knoble, D., Muc, M., Erick, J., role of renal prostaglandins and ki- Thomas, P. E. and Kelley, M.: Cy- on chondrocytes, inhibitors of, 1519 nins and muscarinic receptors in, opioid inhibition of, in macrophages, tochrome P-450 2E1 is the not the 1197 1491 sole catalyst of chlorzoxazone hy- effects ofAng II on, in young genetically Interleukin-1f3, effects on bradykinin re- droxylation in rat liver micro- hypertensive rats, 768 ceptors, in rat lung, 1257 somes, 1156 effects of CGRP on, 56 Intestine, absorption and glucuronidation Jejunal arterioles, regulation by capsa- excretory responses to volume expan- icin-sensitive nerves, in N. brasil- of losartan by, in rat, 816 sion, central kappa opioid effects Intraocular pressure, adenosine receptor iensis-sensitized rats, 337 on, 199 Jewell, H., see Ruscoe, J. E., 393 modulation of, in rabbits, 320 membrane degradation of buserelin Jhamandas, K., see M#{233}nard,D. P., 887 313-(4-’25lodophenyl)-tropane-2-carboxylic pathways, in rat, 709 Jiang, Q., Seyed-Mozaffari, A., Sebastian, acid methyl ester, see [125I]RTI-55 metabolism of exogenous cyclic AMP to A., Archer, S. and Bidlack, J. M.: Ionic currents, dimethyl sulfoxide effects adenosine in, in rat, 728 Preventing morphine antinoci- on, in guinea pig ventricular nitric oxide dose-response study in, after ceptive tolerance by irreversible preparations, 1273 inhibition of EDRF, in rat, 855 mu opioid antagonists before the Ion transport, in colonic mucosa, ET- Kim, C., Roberts, A. M. and Joshua, I. G.: onset of their antagonism, 680 mediated, in rat, 1313 Differences in the capsaicin-in- Jiang, X.-M., see Martini, R, 427 1P3, see Inositol trisphosphate duced dilation of arterioles and Johns, R. A., see Rengasamy, A., 599 Irideal arterioles, sympathetic vasocon- venules in rat striated muscle, Johnson, G. A., see Kudlacek, P. E., 582 striction of, modulation by sen- 605 Johnson, M. F., see Ervin, G. N., 1203 sory nerves and NO in, in rat, 918 Kim, S., Ohta, K., Hamaguchi, A., Omura, Johnson, S. W., see Wu, Y.-N., 576 1RL1620 T., Yukimura, T. , Miura, K., Jolicoeur, F. B., see M#{233}nard,D. P., 887 effects on basilar artery, 1 Inada, Y., Ishimura, Y., Chatani, Jollow, D., see Grossman, S., 870 mediation of colonic ion transport by, in F. and Iwao, H.: Angiotensin II Jones, E. A., see Yurdaydin, C., 185 rat, 1313 type I receptor antagonist inhib- Joshua, I. G., see Kim, C., 605 Ischemia/reperfusion its the gene expression of trans- Jung, S. Y., see George, S. R., 373 effects of phenylephrine-induced pre- forming growth factor-131 and ex- conditioning on, in rat hearts, 689 Kagey-Sobotka, A., see Chabot-Fletcher, tracellular matrix in cardiac and splanchnic, carvedilol effects in SAO M. C., 1147 vascular tissues of hypertensive shock in, in rat, 64 Kaiser, F. C., see Palmer, G. C., 1023 rats, 509 Ischemialreperfusion injury, sodium chan- Kamiyama, T., see Takeo, S., 1403 Kimura, T., see Koganei, H., 1337 nel blockade by class-I-type anti- Kanda, T., Araki, M., Nakano, M., Imai, Kindling seizures, FPL 13950 effects arrhythmic agents after, 1403 S., Suzuki, T. and Murata, K.: against, 1023 Ishihara, K., Alkondon, M., Montes, J. G. Chronic effect oflosartan in a mu- King, S. W., see Wallace, A. A., 168 and Albuquerque, E. X.: Nicotinic rime model of dilated cardiomyop- Kinins, renal, role in cicletanine effects on responses in acutely dissociated athy: Comparison with captopril, kidney function, 1197 rat hippocampal neurons and the 955 Kirifides, A. L., see Aloyo, V. J., 435 selective blockade of fast-desensi- Kapusta, D. R., see Greenberg, S. S., 257 Kirk, H. R., see Monroe, P. J., 1057 tizing nicotinic currents by lead, Kapusta, D. R. and Obih, J. C.: Central Kitazono, T., Heistad, D. D. and Faraci, F. 1471 kappa opioids blunt the renal ex- M.: Dilatation of the basilar ar- Ishihara, K., Alkondon, M., Montes, J. G. cretory responses to volume ex- tery in response to selective acti- and Albuquerque, E. X.: Ontogen- pansion by a renal nerve-depen- vation of endothelin B receptors ically related properties of N- dent mechanism, 199 in vivo, 1 methyl-D-aspartate receptors in Kar, S., see M#{233}nard,D. P., 887 Klaassen, C. D., see Liu, J., 977 rat hippocampal neurons and the Karpinski, E., see Liu, Q.-Y., 32 Klein-Robbenhaar, G., see Wang, T., 1382 age-specific sensitivity of develop- Kashimoto, T., see Tachikawa, E., 629 Klinghofer, V., see Tracey, W. R., 1295 ing neurons to lead, 1459 Katsura, M., Ohkuma, S., Tsujimura, A. Klitenick, M. A. and Wirtshafter, D.: Be- Ishii, R., Shinozuka, K., Kunitomo, M., and Kuriyama, K. : Increase of di- havioral and neurochemical ef- Hashimoto, T. and Takeuchi, K: azepam binding inhibitor mRNA fects ofopioids in the paramedian Characterization of the facilita- levels in the brains of chronically midbrain tegmentum including tory prejunctional purinoceptor ethanol-treated and -withdrawn the median raphe nucleus and on adrenergic nerves of the rabbit mice, 1529 ventral tegmental area, 327 ear artery, 1390 Katz, J. L., see Pell#{243}n,R., 138 Knapp, D. J., see Criswell, H. E., 526 Ishimura, Y., see Kim, S., 509 Kaufmann, M. A., Castelli, I., Pargger, H. Knight, P. M., see Rudy, A. C., 88 Iskander, M. N., see Challinor-Rogers, J. and Drop, L. J.: Nitric oxide dose- Knoble, D., see Jayyosi, Z., 1156 L., 778 response study in the isolated Ko, C.-P., see Bowersox, S. S., 248 Isobutylmethylxanthine, effects on acid se- perfused rat kidney after inhibi- Kobayashi, H., see Kuwabara, T., 1114 cretion, in rabbit gastric glands, tion of endothelium-derived re- Kobayashi, S., see Kuwabara, T., 1114 1396 laxing factor synthesis: The role Koch, K., see Showell, H. J., 176 Isopropyl-6-benzyloxy-4-methoxymethyl- of serum albumin, 855 Koga, H., see Takanashi, H., 624 f3-carboline-3-carboxylate, see Keiser, J. A., see Reynolds, E. E., 1410 Koganei, H., Kimura, T. and Satoh, S.: Abecarnil Kelley, M., see Jayyosi, Z., 1156 Effects of beta adrenoceptor ago- I 572 Index Vol. 273

nists and antagonists on adrenal ethylene in male and female Liver, see also under Hepatic catecholamine release in re- mice, 561 ATRA prevention ofCYP2C11 pretrans- sponse to splanchnic nerve stim- Lee, T. J.-F., see Chen, F.-Y., 895 lation down regulation in vitamin ulation in anesthetized dogs: Role Lefevre, P., see Bonnafous, C., 995 A deficiency in, in male rat, 427 of beta-i and beta-2 adrenocep- Leff, A. R., see Mu#{241}oz,N. M., 850 cytochrome P-450 isozyme effects on tors, 1337 Lejeune, F., see Gobert, A., 1032 chlorzoxazone hydroxylation in, Konda, Y., see Miwa, H., 367 Lejeune, F., see Millan, M. J., 1418 in rat microsomes, 1156 Kong, D. C. M., see Challinor-Rogers, J. L., Lester, R., see Little, J. M., 1551 ethanol-induced damage, effects of vita- 778 Leu-enkephalin, brain and plasma levels, mm E supplementation on, 455 Koo, W.-S., Gengaro, P. E., Burke, T. J. with thioacetamide-induced ful- human, UDP-glycosyltransferases from, and Schrier, R. W.: Verapamil at- minant hepatic failure, in rats, characterization of, with photo- tenuates calcium-induced mito- 185 affinity analogs, 1551 chondrial swelling and respira- Leukocytes, adhesion to smooth muscle LLC-PK1 epithelial cells, secretion of tory dysfunction, 206 cells, carvedilol inhibition of, cAMP and cGMP by, effects of ni- Kotake, H., see Yoshida, A., 702 1442 tric oxide on, 16 Kothstein, T., see Wallace, A. A., 168 Leukotriene B4, receptor antagonist CP- L-NMA, see LNGmonomethylarginine Kouchi, T., see Yoshida, A., 702 105696 pharmacologic activity, LNGmonomethylarginine, reduction of Krauss, A. H-P., see Woodward, D. F., 285 176 carrageenan-induced pleurisy by, Krieter, P. A., Colletti, A. E., Miller, R. R. Levcromakalim, antagonists, glibencla- in rat, 1295 and Stearns, R. A.: Absorption mide analogs as, in rat aorta, 778 Local anesthesia, effects in cardiovascular and glucuronidation of the angio- Levodopa, repeated daily, effects on rota- response to cocaine, in conscious tensin II receptor antagonist lo- tion and striatal c-fos expression, rabbits, 128 sartan by the rat intestine, 816 1483 Locus ceruleus neurons, adenosine A1 re- Krowicki, Z. K. and Hornby, P. J.: Seroto- Li, B., see Liu, Q.-Y., 32 ceptor-activated potassium cur- nm and thyrotropin-releasing Li, C., see Bowersox, S. S., 248 rent in, characterization of, in rat, hormone do not augment their ef- Li, S., see Liu-Chen, L.-Y., 1047 537 fects on gastric motility on their Li, Y., see Yurdaydin, C., 185 Loeffler, R. F., see Gullikson, G. W., 1123 microinjection into the nucleus Liebentritt, D. K, see Kudilacek, P. E., 582 Loew, G. H., see Maguire, P. A., 842 raphe obscurus of the rat, 499 LIGAND, and FASA, resolution of benzo- Lonchampt, M., see F#{233}l#{233}tou,M., 1071, Kudlacek, P. E., Anderson, R. J., Lieben- cliazepine receptor heterogeneity 1078 tritt, D. K., Johnson, G. A. and in rat spinal cord with, 842 Lopez, B. L., see Christopher, T. A., 64 Huerter, C. J. : Human skin and Lilling, G., see Gozes, I., 161 Losartan platelet minoxidil sulfotrans- Lin#{233}e,P., see Bril, A., 1264 absorption and glucuronidation of, in rat ferase activities: Biochemical y-Linolenic acid, triglycerides containing, intestine, 816 properties, correlations and con- effects on nerve conduction and chronic effect in murine dilated car- tribution of thermolabile phenol blood flow in diabetic rats, 49 diomyopathy, comparison with sulfotransferase, 582 Linsidomineoprusside, arteriovenous po- captopril, 955 Kudo, K., see Tachikawa, E., 629 tency and selectivity on human Lothman, E. W., see Baraban, S. C., 927 Kuhn, C. M., see Windh, R. T., 1353, 1361 blood vessels, 154 Lovastatin Kuipers, F., see Little, J. M., 1551 Lipid peroxidation, MDMA-induced, L- effects on cardiac and RBC membrane Kuk, J., see Tracey, W. R., 1295 deprenyl protective effects cholesterol content, in normal Kumlin, M., see Matsuda, H., 1182 against, 667 and cardiomyopathic hamsters, Kunitomo, M., see Ishii, R., 1390 Lipophilic peptides, superactive, VIP ana- 863 Kuno, S., see Akai, T., 309 logues, 161 interaction with isradipine, in normal, Kuo, A., see Okada, S. S., 948 Lipopolysaccharide, E. coli endotoxin, hy- female and male volunteers, 121 Kuriyama, K, see Katsura, M., 1529 potension and mortality induced Low-density lipoproteins, oxidation by Kurosawa, S. , see Hasler, W. L., 344 by, hydroxocobalamin effects vascular smooth muscle cells, Kuwabara, T., Uchimura, T., Takai, K., against, in rodents, 257 carvedilol inhibition of, 1442 Kobayashi, H., Kobayashi, S. and 5-Lipoxygenase inhibitors, SB 202235, ef- Lower esophageal sphincter circular Sugiyama, Y.: Saturable uptake fects in allergic asthma models, smooth muscle, signal transduc- of a recombinant human granulo- 1147 tion pathways in, in cat, 482 cyte colony-stimulating factor de- Little, J. M., Drake, R. R., Vonk, R., Lu, G. H., see Panek, R. L., 753 rivative, nartograstim, by the Kuipers, F., Lester, R. and Lucchesi, B. R., see Virkhaus, R., 569 bone marrow and spleen ofrats in Radominska, A. : Characteriza- Ludens, J. H., Clark, M. A. and Lawson, J. vivo, 1114 tion of human liver microsomal A. : Effects of a K channel f3-Lactam antibiotics, intestinal transport, UDP-glycosyltransferases using blocker on glomerular filtration in rat, rabbit and human small photoaffinity analogs, 1551 rate and electrolyte excretion in intestines, 26 Little, P. J., see Windh, R. T., 1361 conscious rats, 1375 Lapp, C. A., see Buccafusco, J. J., 1162 Liu, J., Liu, Y., Barter, R. A. and Klaassen, Lukas, S. E., see Negus, S. S., 1245 Lappi, S. E., see Wagner, J. P., 415 C. D.: Alteration of thyroid ho- Lundy, P. M., see Hamilton, M. G., 940 Laskin, D. L., see Stauber, K. L., 967 meostasis by UDP-glucuronosyl- Lung Laskin, J. D., see Stauber, K. L., 967 transferase inducers in rats, 977 bradykiin receptor subtypes in, in rat, Lawrence, R. A., see Woodward, D. F., 285 Liu, J.-X., see Takeo, S., 1403 1257 Lawson, J. A., see Ludens, J. H., 1375 Liu, Q.-Y., Li, B., Gang, J.-M., Karpinski, CYP2E1 bioactivation of 1,1-dichloro- Lead E. and Pang, P. K. T.: Tetran- ethylene in, in male and female effects on hippocampal nAChR, in rat, drine, a Ca antagonist: Effects mice, 561 1471 and mechanisms of action in vas- trimellitic anhydride-induced allergic effects on hippocampal NMDA recep- cular smooth muscle cells, 32 response in, role of complement tors, in rat, 1459 Liu, Y., see Liu, J., 977 system in, 793 Le Bars, D., see Guirimand, F., 830 Liu-Chen, L.-Y., Yang, H-H., Li, S. and Luthin, G. R., see Wang, P., 959 Ledlow, A., see Conklin, J. L., 762 Adams, J. U.: Effect of intracere- LY 165,163, antagonist effects at D2, D3 Lee, A., see Baraban, S. C., 927 broventricular 13-funaltrexamine and D1 receptors, 1418 Lee, N. M., see Hooke, L. P., 292, 802 on opioid receptors in the rat Lymphocyte blastogenesis, human, gram- Lee, R. P. and Forkert, P.-G.: Pulmonary brain: Consideration of binding icidin suppression of, in rat, 223 CYP2E1 bioactivates 1,1-dichloro- condition, 1047 Lynch, G., see Bahr, B. A., 902 1995 Index I 573

Lynch, J. J. III, Yu, S. P., Canzoniero, L. MathOt, R. A. A., Van Den Aarsen, B. C. F. phine in the rat spinal cord: Al- M. T., Sensi, S. L. and Choi, D. M., Soudijn, W., Breimer, D. D., teration ofcalcitonin gene-related W. : Sodium channel blockers re- Ijzerman, A. P. and Danhof, M.: peptide-like immunostaining and duce oxygen-glucose deprivation- Pharmacokinetic-pharmacody- receptor binding sites, 887 induced cortical neuronal injury namic modelling of the cardiovas- Mendelson, J. H., see Negus, S. S., 1245 when combined with glutamate cular effects of R- and S-N6- Menius, J. A., Jr., see Ervin, G. N., 1203 receptor antagonists, 554 phenylisopropyladenosine in Mercuri, N. B., see Wu, Y.-N., 576 Lynch, J. J., Jr., see Wallace, A. A., 168 conscious normotensive rats, 405 Meredith, D. B., see Maguire, P. A., 842 Matsuda, H., Dahl#{233}n,S.-E., Kumlin, M., Mereto, E., see Martelli, A., 113 Ma, X.-L., see Christopher, T. A., 64 Puustinen, T., Miyatake, K. and Mesangial cells, proliferation and han- MacAllister, R. J., Calver, A. L., Riezebos, Hedqvist, P.: Pharmacodynamics dling of IgG complexes by, hepa- J., Collier, J. and Vallance, P.: of 15(S)-hydroperoxyeicosatetrae- rim effects on, 80 Relative potency and arterio- noic (15-HPETE) and 15(S)-hy- Mesenteric artery, endothelial function, venous selectivity of nitrovasodi- droxyeicosatetraenoic acid ( 15- carvedilol effects on, in SAO lators on human blood vessels: An HETE) in isolated arteries from shock in, in rat, 64 insight into the targeting of nitric guinea pig, rabbit, rat and hu- Mesoaccumbens dopamine system, re- oxide delivery, 154 man, 1182 sponses to glutamate, effects of Macrophages Mattana, J. and Singhal, P. C.: Heparin repeated cocaine on, 445 antigen processing by, z6-tetrahydro- attenuates the effect of mitogenic Mesocortex, dopamine release, effects of cannabinol modulation of, 1216 vasoconstrictors on mesangial prenatal cocaine exposure on, bone marrow-derived, TNF-a from, inhi- cell proliferation and handling of 1211 bition by adenosine analogues, immunoglobulin G complexes, 80 Messenger RNA 1506 Mattioli, F., see Martelli, A., 113 cerebral diazepam binding inhibitor 1ev- opioid modulation of, 1491 Maurel-Remy, S., see Millan, M. J., 1418 els, effects of ethanol dependence Maddatu, T., see Runnegar, M. T., 545 Mavridis, M., see Millan, M. J., 1418 and withdrawal on, in mice, 1529 Madras, B. K, see Gracz, L. M., 1224 Mayer, D., see Mu#{241}oz,N. M., 850 from human, rat and rabbit small intes- Maeda, N., see Nomura, K, 1001 M&B 22,948, modulation of ANP-depen- tines, functional expression of Maggs, J. L., see Ruscoe, J. E., 393 dent endothelin effects by, 744 13-lactam antibiotic and dipeptide Maguire, P. A., Mechanick, J. I., Davies, M. McAllister, K., see Mu#{241}oz,N. M., 850 transporter in Xenopus laevis oo- F., Ellis, D. M., Meredith, D. B. and McCook, E. C., see Wagner, J. P., 415 cytes injected with, 26 Loew, G. H.: Resolving receptor McCown, T. J., see Criswell, H. E., 526 psychostimulant induction, in rat fore- heterogeneity using Fourier- McCoy, K. L., Gainey, D. and Cabral, G. brain, 909 derived affinity spectrum analy- A. : 6-Tetrahydrocannabinol zif/268 and preprodynorphin expres- sis and LIGAND: Benzodiazepine modulates antigen processing by sion, dose-related effects of am- receptors in the rat spinal cord, macrophages, 1216 phetamine or methamphetamine 842 McDonald, T. F., see Ogura, T., 1273 on, in rat forebrain, 909 Mahieu, J.-P., see F#{233}l#{233}tou,M., 1071 McGinty, J. F., see Wang, J. Q., 909 Metalloprotease synthesis inhibitors, on Mailman, R. B., see Heidenreich, B. A., 516 McNutt, R. W., see Bilsky, E. J., 359 chondrocytes, identification of, Major, T. C., see Panek, R. L., 753 McPherson, G. A., see Challinor-Rogers, J. 1519 Makhuli, M. J., Polkowski, C. A. and L., 778 Met-enkephalin, brain and plasma levels, Grassl, S. M. : Organic anion McQuade, R. D., see Billard, W., 273 with thioacetamide-induced ful- transport in rabbit renal basolat- McWhinney, C. D., see Bradshaw, M., minant hepatic failure, in rats, eral membrane vesicles, 146 1506 185 Malfatto, G., see Zaza, A., 1095 MDL 201,112, TNF-a inhibition by, 1506 Methadone, in vitro administration, opioid Manning, C. D., see Barnette, M. S., 674 MDL 201,449, TNF-a inhibition by, 1506 tolerance in human placenta due Mapp, P. I., see Walsh, D. A., 461 MDL 201,451, TNF-a inhibition by, 1506 to, 987 Marshall, L. A., see Chabot-Fletcher, M. MDL 201,484, TNF-a inhibition by, 1506 Methamphetamine, dose-related effects C., 1147 MDMA, see Methylenedioxymethamphet- on zif/268 and preprodynorphin Martelli, A., Allavena, A., Brambilla Cam- amine mRNA expression, in rat fore- part, G., Canonero, R., Ghia, M., Mechanick, J. I., see Maguire, P. A., 842 brain, 909 Mattioli, F., Mereto, E., Robbi- Median raphe nucleus, behavioral and [3H]2-Methoxy-idazoxan, see RX 821002 ano, L. and Brambilla, G.: In vitro neurochemical effects of opioids N-Methyl-D-aspartate receptors and in vivo testing of hydralazine in, 327 felbamate blockade, 878 genotoxicity, 113 Mehlis, B., see Kertscher, U., 709 hippocampal, lead effects on, in rat, Martin, B. R., see Adams, I. B., 1172 Mehrotra, D. V., see Gullikson, G. W., 1123 1459 Martin, C., see F#{233}l#{233}tou,M., 1071 Meimer, J., see Nelson, S. D., 315 Methylenedioxymethamphetamine Martin, G. E., see Pendley, C. E., 1015 Melanocortin peptides, required for acti- 5-HT neurotoxicity, L-deprenyl protec- Martin, T. J., see Hemby, S. E., 591 vation of melanocortin-3 and tive effects against, 667 Martini, R., Butler, A. M., Jiang, X.-M. melanocortin-4 receptors, struc- striatal release of dopamine induced by, and Murray, M. : Pretranslational tural determinants of, 367 modulation by 5-HT/GABA inter- down regulation of cytochrome Melanocortin-3 receptor, activation of, actions in substantia nigra, 1063 P450 2Cll in vitamin A-deficient structural determinants of pep- [(S)-3-Methyl-5-( 1-methyl-2-pyrrolidi- male rat liver: Prevention of di- tides required for, 367 nyl)isoxazole], see ABT-418 etary inclusion of retinoic acid, Melanocortin-4 receptor, activation of, i-Methyl-4-phenyl-l,2,3,6-tetrahydropyri- 427 structural determinants of pep- dine, terguride in combination Mashiba, H., see Yoshida, A., 702 tides required for, 367 with SKF 82958 for cynomolgus Mastoparan, reduction of opioid/clonidine Melatonin, agonist modulation of 5-HT2A monkeys lesioned with, 309 supraspinal antinociception by, receptor-mediated neurotrans- Meydani, M., see Sadrzadeh, S. M. H., 455 effects ofNAC-13-END on, in mice, mission, in rat, 304 Meyer, E. R., see Cicero, T. J., 386 787 Mello, N. K., see Negus, S. S., 1245 Mi, Z. and Jackson, E. K: Metabolism of Mathison, R. and Davison, S.: Regulation Melvin, L. S., Jr., see Showell, H. J., 176 exogenous cyclic AMP to adeno- ofjejunal arterioles by capsaicin- M#{233}nard, D. P., van Rossum, D., Kar, S., sine in the rat kidney, 728 sensitive nerves in Nippostrong. Jolicoeur, F. B., Jhamandas, K Michel, M. C., see Erdbrugger, W., 1287 ylus brasiliensis-sensitized rats, and Quirion, R.: Tolerance to the Michotte, Y., see Deleu, D., 1323 337 antinociceptive properties of mor- Microcystin, toxicity of, 545 I 574 Index Vol. 273

Microdialysis intravenous, effects on C-fiber reflex, in water in, in guinea pig ventricu- intravenous heroin effects on extracellu- rat, 830 lar preparations, 1273 lar nucleus accumbens dopamine locomotor effects in median raphe nu- electrophysiological effects of BRL- concentrations by, 591 cleus, 327 32872 on, in guinea pig cardiac iso- study of peripheral L-dopa pharmacoki- tolerance lated preparations, 1264 netics, in beagle dog, 1323 effects in CGRP-like immunostaining skeletal Micropuncture, study of cicletanine effects and receptor binding sites, in rat L-dopa pharmacokinetics in, effects of on kidney function, in rats, 1190 spinal cord, 887 carbidopa and entacapone on, in Microsomes, cytochrome P-450 isozyme ef- prevention of, with irreversible opi- beagle dog, 1323 fects on chlorzoxazone hydroxyla- oid antagonists, 680 sarcoplasmic reticulum, ‘251-radioio- tion in, in rat liver, 1156 4-Morpholinecarboximidine-N-l-adaman- dinated myotoxin a binding site Midbrain tyl-N’-cyclohexylhydrochloride, properties in, 934 adenosine effects on dopamine neurons see U-37883A striated, capsaicin-induced dilation of in, 576 3-Morpholinosydnonimine, effects on se- arterioles and venules in, in rat, paramedian tegmentum, behavioral and cretion ofcAMP and cGMP by ep- 605 neurochemical effects of opioids ithelial and fibroblast cells, 16 Muttreja, M. R., see Okada, S. S., 948 in, 327 Morrison, S. F. and Ge, Y.-Z.: Adrenergic Myocardial infarction, healing, effects on Miljanich, G. P., see Bowersox, S. S., 248 modulation of a spinal sympa- electrophysiologic effects of pro- Millan, M. J., see Gobert, A., 1032 thetic reflex in the rat, 380 cainamide and N-acetylprocain- Millan, M. J., see Schreiber, R., 101 Morrow, A. L., see Criswell, H. E., 526 amide, 315 Millan, M. J., Mavridis, M., Rivet, J.-M., Mortality, endotoxin-induced, hydroxoco- Myocytes Audinot, V., Gobert, A., Lejeune, balamin effects against, in ro- electrophysiological effects of BRL- F. , Brocco, M. , Newman-Tan- dents, 257 32872 on, in guinea pig cardiac iso- credi, A., Maurel-Remy, S. and Mosher, J. T., see Ervin, G. N., 1203 lated preparations, 1264 Bervoets, K.: Antagonist proper- Motilin receptors, antagonist GM-109 ventricular, dimethyl sulfoxide effects ties of LY 165,163 at pre- and pharmacological properties, in on action potentials, ionic cur- postsynaptic dopamine D2, D3 rabbit small intestine smooth rents and cell water in, in guinea and D1 receptors: Modulation of muscle, 624 pig preparations, 1273 agonist actions at 5-HT1A recep- Motor activity, effects of P’FT vs cocaine Myotoxin a, ‘251-radioiodinated, binding tors in vivo, 1418 HC1 on, 656 site properties in skeletal muscle Miller, M. J. S., see Greenberg, S. S., 257 Motor functions, esophageal, effects of re- sarcoplasmic reticulum, 934 Miller, R. R., see Krieter, P. A., 816 combinant human hemoglobin Minoxidil sulfotransferase, skin and plate- on, in opossum, 762 Nabata, H., see Takanashi, H., 624 let activities, in human, 582 Motzo, C., see Dazzi, L., 241 NAC-13-END, see aNacetylj3..endorphln Misoprostol, active isomer of, polymeric MPTP, see l-Methyl-4-phenyl- 1,2,3,6- (1-31) delivery, effects on systemic tetrahydropyridine aN..acetylp..endorphin..(1..31), effects on availability and uterotonic activ- Mu, J., see Deadwyler, S. A., 734 mastoparan reduction of opioid/ ity, 1123 Muc, M., see Jayyosi, Z., 1156 clonidine supraspinal antinoci- Mitani, Y., see Yoshida, A., 702 Mucosa, colonic, ET-mediated ion trans- ception, in mice, 787 Mitochondria, calcium-induced injury, port in, in rat, 1313 N-acetylprocainamide, electrophysiologic verapamil effects against, 206 Mulder, G. J., see Snel, C. A. W., 1300 effects, effects of infarct healing Miura, A., see Takeo, S., 1403 Mullins, U. L., see Eison, A. S., 304 on, 315 Miura, K., see Kim, S., 509 Mufioz, N. M., Rabe, K F., Vita, A. J., nAChR, see Nicotinic acetylcholine recep- Miwa, H., Gantz, I., Konda, Y., Shimoto, Y. McAllister, K, Mayer, D., Weiss, tors and Yamada, T.: Structural de- M. and Leff, A. R.: Paradoxical Nadasdi, L., see Bowersox, S. S., 248 terminants of the melanocortin blockade of beta adrenergically Nadolol, effects in SNS-evoked adrenal peptides required for activation of mediated inhibition of stimulated catecholamine release, in anes- melanocortin-3 and melanocor- eosinophil secretion by salmet- thetized dogs, 1337 tin-4 receptors, 367 erol, 850 Nakane, M., see Tracey, W. R., 1295 Miyatake, K., see Matsuda, H., 1182 Murata, K., see Kanda, T., 955 Nakano, M., see Kanda, T., 955 Mizuta, E., see Akai, T., 309 Murray, J., see Conklin, J. L., 762 Nakayama, K, see Tamai, I., 26 Monoamines, uptake inhibition effects in Murray, M., see Martini, R., 427 Nalbuphine, antinociceptive effects in tail- cardiovascular response to co- Muscarinic autoreceptors, m2 subtype withdrawal procedure, buprenor- caine, in conscious rabbits, 128 identification, in rat striatum, phine antagonism of, in rhesus Monroe, P. J., Smith, D. L., Kirk, H. R. and 273 monkey, 1345 Smith, D. J.: Spinal nonadrener- Muscarinic receptors Naline, E., see F#{233}l#{233}tou,M., 1071 gic imidazoline receptors do not bladder subtypes, 959 Naloxone, dynorphin A-(2-17) antinocicep- mediate the antinociceptive ac- gallbladder muscle subtypes, 650 tion insensitive to, in writhing as- tion ofintrathecal clonidine in the interaction with K channel blockers, say, 802 rat, 1057 effects on atrial repolarization, L-NAME, see NGNitroLarginine methyl Montes, J. G., see Ishihara, K., 1459; Ishi- 1095 ester ham, K., 1471 regulation of cardiac CF’TR Cl current Nanji, A. A., see Sadrzadeh, S. M. H., 455 Mood, intravenous caffeine effects on, in by, effects of quaternary ammo- j3-Naphthoflavone, induction of CYP1A1 stimulant drug abusers, 351 nium compounds on, 470 by, flow cytometry of epidermal Moons, M. M., see Snel, C. A. W., 1300 role in cicletanine effects on kidney cells refractory to, in mice, 967 Moravec, C. S., see Pogue, D. H., 863 function, 1197 Naphthopyrans, metalloprotease inhibi- Morgan, D. J., see Ng, C. Y., 1332 Muscle, see also Smooth muscle tion by, 1519 Morphine colonic, bradkynin-evoked contraction Napier, J. J., see Palmer, G. C., 1023 analgesic effects, sensitivity to, adverse of, 344 Napier, T. C., see Heidenreich, B. A., 516 effects of paternal opiate expo- gallbladder, muscarinic receptor sub- Naranjo, C. A., see George, S. R., 373 sure on, 386 types and signal transduction Nartograstim, uptake by bone marrow antinociceptive effects in tail-with- pathways in, 650 and spleen, in rats, 1114 drawal procedure, buprenorphine papillary Nash, J. F., see Yamamoto, B. K, 1063 antagonism of, in rhesus monkey, dimethyl sulfoxide effects on action Natsukawa, T., see Takeo, S., 1403 1345 potentials, ionic currents and cell Nawada, T., see Yoshida, A., 702 1995 Index 1575

N-CPM-MET-CAMO, see N-Cyclopropyl- Nicotiic acetylcholine receptors Ohizumi, Y., see Ohkura, M., 934 methyl-513-methyl-1413-(p-nitroci- ABT-418 binding characteristics, in rat Ohkuma, S., see Katsura, M., 1529 namoylamino)-7,8-dihydromor- brain, 1434 Ohkura, M., Furukawa, K-I., Oikawa, K. phinone hippocampal, lead effects on, in rat, and Ohizumi, Y.: The properties N-CPM-TAMO, see 14a,l4’13-[Dithiobis[(2- 1471 of specific binding site of 1251 oxo-2, 1-ethanediyl)imino]lbix- Nikkel, A., see Asia, K. E., 1483 radioiodinated myotoxin a, a 7,8-dihydro-N-(cyclopropylmeth- Nippostrongylus brasiliensis, capsaicin novel Ca releasing agent, in yl)normorphinone regulation of jejunal arteriles in skeletal muscle sarcoplasmic re- Negus, S. S., Mello, N. K., Portoghese, P. rats sensitized to, 337 ticulum, 934 S., Lukas, S. E. and Mendelson, J. Nitric oxide Ohta, K., see Kim, S., 509 H.: Role of delta opioid receptors dose-response study in isolated perfused Oikawa, K., see Ohkura, M., 934 in the reinforcing and discrimina- rat kidney after inhibition of Oka, K., see Hirano, T., 223 tive stimulus effects of cocaine in EDRF synthesis, 855 Okada, S. S., Kuo, A., Muttreja, M. R., rhesus monkeys, 1245 effects on secretion of cAMP and cGMP Hozakowska, E., Weisz, P. B. and Nelson, S. D., Coyne, K. S. and Meimer, J.: by epithelial and fibroblast cells, Barnathan, E. S.: Inhibition of The discordant influences of in- 16 human vascular smooth muscle farct healing on the electrophysi- modulation of sympathetic vasoconstric- cell migration and proliferation ologic effects of procainamide and tion by, in rat irideal arterioles, by f3-cyclodextrin tetradecasul- N-acetylprocainamide, 315 918 fate, 948 Neonates, sensitivity to mu opiate antino- role in hydroxocobalamin effects against Okada, T., see Hosakawa, M., 1313 ciception, in rat, 1353 endotoxin-induced hypotension Okuma, M., see Hosakawa, M., 1313 and mortality, in rodents, 257 Nerve conduction, diabetic, effects of O’Leary, E. C., Schelm, J. A. and Simpson, Nitric oxide donors, arteriovenous profile, evening primrose oil on, in rats, P. J.: Activated recombinant hu- in human, 154 49 man protein C does not attenuate Nitric oxide synthase, effects of inhala- Neurochemistry, opioid effects in mid- recruitment of neutrophils in rat tional anesthetics on, 599 brain tegmentum on, 327 models of acute inflammation, Nitric oxide synthase inhibitors, LNG Neurokinin 1 receptor, mediation of vaso- 193 monomethylarginine, reduction of depressor effects of substance P Olszewski, B., see Reynolds, E. E., 1410 carrageenan-induced pleurisy by, in tractus solitarius nucleus by, Omura, T., see Kim, S., 509 617 in rat, 1295 O’Neill, P. M., see Ruscoe, J. E., 393 Neuromuscular junction, w-conotoxin NGNitroLarginine methyl ester, effects Oocytes, Xenopus laevis, injected with blockade of voltage-sensitive cal- on renal effects of CGRP, 56 mRNA from human, rat and rab- cium channels at, in mouse, 248 Nitroglycerin bit small intestines, functional Neuronal cells, catecholaminergic, kappa arteriovenous potency and selectivity on expression of 3-lactam antibiotic opioid receptor-mediated sup- human blood vessels, 154 and dipeptide transporter in, 26 pression of voltage-activated po- tolerance to, tissue thiols content dur- Opiate withdrawal syndrome, behavioral tassium channels in, 927 ing, in rats, 94 and endocrine profiles, in rats, Neurotensin receptors, antagonist ligand S-Nitrosoglutathione, arteriovenous po- 1361 [3H]SR 48692 binding sites, in tency and selectivity on human Opioid receptors guinea pig brain, 1450 blood vessels, 154 delta Neurotoxicity Nitrovasodilators, potency and arterio- antiproliferative effects on CD4 and calpain, induction in long-term hip- venous selectivity on human CD8 murine T cells, 1105 pocampal slices, 902 blood vessels, 154 mediation ofantinociception by, in rat 5-HT, MDM.A-induced, L-deprenyl pro- Nock, B., see Cicero, T. J., 386 tail flick test after noxious ther- tective effects against, 667 Nomura, K., Maeda, N., Yoshino, T. and Yamaguchi, I.: Different mecha- ma! stimulation of one hindpaw, Neurotransmission, 5-HT2A receptor- 1428 mediated, melatonin agonist nisms mediated by dopamine Dl and D2 receptors are involved eti- nonpeptidic agonists, SNC 80 phar- modulation of, in rat, 304 ologically in activity stress gastric macology, 359 Neurotransmitters basal and stress-induced release in lesion of the rat, 1001 role in self-administration and dis- Noxious thermal stimulation, of one hind- brain, modulation by abecarnil crimination of cocaine, in rhesus and imidazenil, in rat, 241 paw, antinociceptive effects, me- monkeys, 1245 diation by j.L-, 5- and K-opiate re- effects in rat cortex, 230 kappa ceptors, in rat tail flick test, 1428 Neutral endopeptidase inhibitors, modula- agonist modulation of macrophages, Nucleus accumbens, extracellular dopa- tion of ANP-dependent endothe- 1491 mine concentrations lin effects by, 744 central, effects on renal excretory re- effects of intravenous heroin on, by mi- Neutrophils, activated protein C effects sponses to volume expansion, 199 on, in rat models of acute inflam- crodialysis, 591 mediation ofantinociception by, in rat effects of PTT vs cocaine HC1 on, 656 mation, 193 tail flick test after noxious ther- Nucleus raphe obscurus, serotonin(FRH Newman-Tancredi, A. , see Gobert, A., ma! stimulation of one hindpaw, microinjection into, effects on 1032 1428 gastric motility, in rat, 499 Newman-Tancredi, A., see Millan, M. J., suppression of voltage-activated po- 1418 Obergfell, A., see Szabo, B., 128 tassium current by, in cate- Ng, C. Y., Angus, P. W., Ghabrial, H., Obih, J. C., see Kapusta, D. R., 199 cholaminergic neuronal cells, 927 Chou, S. T., Arnolda, L., Morgan, O’Connor, L., see Cicero, T. J., 386 mu D. J. and Smallwood, R. A.: Right O’Connor, W. T., see Carter, A. J., 637 antagonist binding studies with intact heart failure impairs hepatic oxy- Oda, K., see Hosakawa, M., 1313 SH-SY5Y cells, 721 genation and theophylline clear- O’Dowd, B. F., see George, S. R., 373 antinociceptive effects ance in rats, 1332 Offspring development, adverse effects of buprenorphine antagonism of, in Ng, G. YK., see George, S. R., 373 paternal opiates exposure on, 386 rhesus monkey tail-withdrawal Nichols, D. E., see Heidenreich, B. A., 516; Ogura, T., Shuba, L. M. and McDonald, T. procedure, 1345 Sprague, J. E., 667 F.: Action potentials, ionic cur- neonatal sensitivity to, in rat, 1353 Nicotine, acute and chronic, effects of caf- rents and cell water in guinea pig effects of intracerebroventricular (3- feine on ventilation during, in ventricular preparations exposed funaltrexamine on, in rat brain, rhesus monkeys, 1085 to dimethyl sulfoxide, 1273 1047 I 576 Index Vol. 273

irreversible antagonists, prevention of water in, in guinea pig ventricu- R-N6-Phenylisopropyladenosine morphine antinociceptive toler- lar preparations, 1273 cardiovascular effects, pharmacokinetic- ance with, 680 electrophysiological effects of BRL- pharmacodynamic modelling of, in mediation ofantinociception by, in rat 32872 on, in guinea pig cardiac conscious normotensive rats, 405 tail flick test after noxious ther- isolated preparations, 1264 modulation of intraocular pressure by, mal stimulation of one hindpaw, Pargger, H., see Kaufmann, M. A., 855 in rabbits, 320 1428 Park, B. K, see Ruscoe, J. E., 393 S-N6-Phenylisopropyladenosine tolerance and dependence to, onto- Park, G. Y., see Bahr, B. A., 902 cardiovascular effects, pharmacoki- gency of, in rat, 1361 Parkinsonism, MPTP-lesioned, combina- netic-pharmacodynamic model- Opioids tion treatment of terguride with ling of, in conscious normotensive acute and chronic effects, dynorphin A SKF 82958 for, in cynomolgus modulation of, 292 rats, 405 monkeys, 309 modulation of intraocular pressure by, behavioral and neurochemical effects, in Parli, C. J., see Gidda, J. S., 695 in rabbits, 320 midbrain tegmentum, 327 Partilla, J. S., see Silverthorn, M. L., 213 Phosphodiesterase, cGMP, inhibition of, binding studies with intact SH-SY5Y Patel, M. J., Wypij, D. M., Rose, D. A., modulation of ANP-dependent cells, 721 Rimele, T. J. and Wiseman, J. S.: endothelin effects by, 744 paternal exposure, adverse effects on Secretion of cyclic GMP by cul- Phosphodiesterase IV inhibitors offspring development and sensi- tured epithelial and fibroblast effects on acid secretion, in rabbit gas- tivity to morphine-induced anal- cell lines in response to nitric ox- gesia, 386 tric glands, 1396 ide, 16 peptide brain and plasma levels, with Patrick, G. S., see Welch, S. P., 1235 suppression of superoxide production thioacetamide-induced fulminant by, in guinea pig eosinophils by, Patt, W. C., see Reynolds, E. E., 1410 hepatic failure, in rats, 185 Pauly, J. R., see Anderson, D. J., 1434 674 supraspinal antinociceptive effects, Pazdalski, P. 5., see Aloyo, V. J., 435 Photoaffinity analogs, characterization of NAC-(3-END effects on mastopa- PD 156707, pharmacology, 1410 human liver UDP-glycosyltrans- ran reduction of, in mice, 787 PDE, see Phosphodiesterase ferases with, 1551 tolerance to, in human placenta, 987 P#{233}laprat, D., see Betancur, C., 1450 Picken, H., see Conklin, J. L., 762 Organic anions, renal transport, in rabbit Pitcher, G. M., Yashpal, K, Coderre, T. J. renal basolateral membrane yes- Pell#{243}n,R., Flores, P., Ailing, K, Witkin, J. M. and Katz, J. L.: Pharmacolog- and Henry, J. L.: -, 8- And K-opi- ides, 146 ate receptors mediate antinoci- Organic cations, renal transport, site- ical analysis of the scratching ception in the rat tail flick test selective effect of bicarbonate on, produced by dopamine D2 ago- following noxious thermal stimu- 72 nists in squirrel monkeys, 138 lation of one hindpaw, 1428 Osmanovi#{233}, S. S., see Pan, W. J., 537 Pendley, C. E., Fitzpatrick, L. R., Capo- Otto, T., see Erdbrugger, W., 1287 lino, A. J., Davis, M. A., Esterline, Placenta, opioid tolerance in, in human, Overhiser, R. W., see Panek, R. L., 753 N. J., Jakubowska, A., Bertrand, 987 Owyang, C., see Hasler, W. L., 344 P., Guyon, C., Dubroeucq, M.-C. Place preference conditioning, sensitiza- Oxygen delivery and Martin, G. E.: RP 73870, a tion to cocaine reward by, 808 hepatic, effects of right heart failure on, gastrinlcholecystokinin-B recep- Plasma, opioid peptide levels, with thioac- in rats, 1332 tor antagonist with potent anti- etamide-induced fulminant he- LDL, by vascular smooth muscle cells, ulcer activity in the rat, 1015 patic failure, in rats, 185 carvedilol inhibition of, 1442 Penix, L., see Subramaniam, S., 878 Platelets, minoxidil sulfotransferase activ- Oxygen-glucose deprivation, cortical neu- Peptides ities, in human, 582 ronal injury induced by, reduc- blood-brain barrier transport, vera- Platt, 0., see Brugnara, C., 266 tion by sodium channel blockers pamil effects on, in rats, 298 Pleurisy, carrageenan-induced, L-NMA re- in combination with glutamate melanocortin, required for activation of duction of, in rat, 1295 receptor antagonists, 554 melanocortin-3 and melanocor- Plummer, M., see Reynolds, E. E., 1410 Oyaizu, M., see Yoshida, A., 702 tin-4 receptors, structural deter- Pogue, D. H., Moravec, C. S., Roppelt, C., Ozaki, K.-I., see Takanashi, H., 624 minants of, 367 Disch, C. H., Cressman, M. D. Ozawa, M., see Akai, T., 309 opioid, brain and plasma levels, with and Bond, M.: Effect of lovastatin thioacetamide-induced fulminant Palmer, G. C., Stagnitto, M. L., Garske, G. on cholesterol content of cardiac hepatic failure, in rats, 185 E., Napier, J. J., Harris, E. W., and red blood cell membranes in superactive lipophilic, VIP analogues, Kaiser, F. C., Griffith, R. C., normal and cardiomyopathic 161 Woodhead, J. H., White, H. S. and hamsters, 863 Perkins, W. E., see Gullikson, G. W., 1123 Swinyard, E. A.: Anticonvulsant Polak, J. M., see Walsh, D. A., 461 Perner, R., see Asin, K. E., 1483 efficacy/safety properties of 2- Polkowski, C. A., see Makhuli, 1sI. J., 146 Pettipher, E. R., see Showell, H. J., 176 amino-N-(i,2-diphenylethyl)acet- Polyaspartic acid, effects and interactions Pharmacologic preconditioning, phenyl- amide hydrochloride, 1023 with diuretics and gentamicin on ephrine-induced, in rat hearts, Pan, W. J., Osmanovi#{233}, S. S. and Shefner, urine calcium concentration, 280 S. A. : Characterization of the 689 Porreca, F., see Bilsky, E. J., 359 adenosine A1 receptor-activated Pharmacology, cardiovascular, role of ad- Portoghese, P. 5., see Negus, S. S., 1245 potassium current in rat locus hesion molecules in, meeting re- Potassium A-currents, voltage-sensitive, ceruleus neurons, 537 view, 569 modulation by cannabinoids, in Panek, R. L., Lu, G. H., Overhiser, R. W., Phe-cyclo[Lys-Try(3-tBu)-fiAla-1.trifluoro- hippocampal neurons, 734 Major, T. C., Hodges, J. C. and acetate, see GM-109 Potassium channel blockers Taylor, D. G.: Functional studies Phenol sulfotransferase, thermolabile, but not receptor binding can dis- skin and platelet activities, in hu- interaction with acetylcholine, effects on tinguish surmountable from in- man, 582 atrial repolarization, 1095 surmountable AT1 antagonism, 2-Phenylaminoadenosine, see CV-1808 novel 753 ( + )-l-(3S,4R)-[3-(4-Phenyl-benzyl)-4- diuretic effects, 1382 Pang, C. C. Y., see Elhawary, A. M., 56 hydroxy-chroman-7-yl]cyclopen- effects on glomerular filtration rate Pang, P. K. T., see Liu, Q.-Y., 32 tane carboxylic acid, see CP- and electrolyte excretion, in con- Papillary muscle 105696 scious rats, 1375 dimethyl sulfoxide effects on action po- Phenylephrine, preconditioning, in rat effects on renal tubule function and K tentials, ionic currents and cell hearts, 689 channel activity, 1382 1995 Index 1577

Potassium channels Quinidine, amantadine renal transport nicotinic adenosine A1 receptor-activated, charac- sensitive to, effect of bicarbonate ABT-4i8 binding characteristics, in terization of, in rat locus ceruleus on, 72 rat brain, 1434 neurons, 537 Quinine, amantadine renal transport sen- hippocampa!, lead effects on, in rat, Ca k-activated, blockade by oral do- sitive to, effect of bicarbonate on, 1471 trimazole, in human erythro- 72 purinergic, facilitatory prejunctional, on cytes, 266 Quinpirole, repeated daily, effects on rota- rabbit ear artery adrenergic dimethyl sulfoxide effects on, in guinea tion and striatal c-los expression, nerves, 1390 pig ventricular preparations, 1483 spinal nonadrenergic imidazoline, medi- 1273 Quirion, R., see M#{233}nard,D. P., 887 ation of intrathecal clonidine an- inhibition by antiarrhythmic drugs, in tinociception by, in rat, 1057 Rabe, K. F., see Mu#{241}oz,N. M., 850 thyroid cells, 702 Red blood cells Radominska, A., see Little, J. M., 1551 renal tubule, novel KATP channel Ca k-activated K channels in, block- Hahn, A., see Greven, J., 1197 blocker effects on, 1382 ade by oral clotrimazole, in hu- Raiteri, M. , Bonanno, G. and Vallebuona, voltage-activated, kappa opioid recep- man, 266 F. : In vitro and in vivo effects tor-mediated suppression of, in G6PD-deficient, dapsone hemotoxicity of d-fenfluramine: No apparent catecholaminergic neuronal cells, in, in rat, 870 relation between 5-hydroxytryp- 927 membrane cholesterol content, lovasta- tamine release and hypophagia, Poyser, R. H., see Bril, A., 1264 tin effects on, in normal and car- 643 Preconditioning, phenylephrine-induced, diomyopathic hamsters, 863 Ramachandran, J., see Bowersox, S. S., in rat hearts, 689 Regal, J. F., see Fraser, D. G., 793 248 Preprodynorphin, mRNA expression, Reikersdorfer, C. G., see Rengasamy, A., Ramwell, P. W., see Thomas, G., 1544 dose-related effects of amphet- 599 Raszkiewicz, J. L., see Anderson, D. J., amine or methamphetamine on, 1434 Reiter, L. A., see Showell, H. J., 176 in rat forebrain, 909 Remy, D. C., see Wallace, A. A., 168 Raulf, M., see ErdbrUgger, W., 1287 Probenecid, effects on secretion of cAMP [3H]Rauwolscine, alpha-2-adrenoceptor Renal basolateral membrane vesicles, or- and cGMP by epithelial and fibro- binding, comparison with [3H]2- ganic anion transport in, in rab- blast cells, 16 methoxy-idazoxan, in nine tis- bit, 146 Procainamide, electrophysiologic effects, sues and cell lines, 1287 Renal impairment, elderly persons with, effects of infarct healing on, 315 Ravichandran, L. V., see Rengasamy, A., enantioselective disposition of Procaterol, effects in SNS-evoked adrenal 599 ibuprofen in, 88 catecholamine release, in anes- Razdan, R. K., see Adams, I. B., 1172; Renal tubules thetized dogs, 1337 Welch, S. P., 1235 effects of CGRP on, 56 2f3-Propanoyl-3f3-(4-tolyl) tropane, effects Reboussin, D., see Hemby, S. E., 656 function and K channel activity, novel on nucleus accumbens extracellu- Receptors, see also Autoreceptors; specific KATP channel blocker effects on, lar dopamine concentration and receptors 1382 motor activity, 656 adrenergic site-selective effect of bicarbonate on Prost, J.-F., see F#{233}l#{233}tou,M., 1071; F#{233}l#{233}tou, amantadine transport in, 72 M., 1078 alpha-2 medullary, effects in conscious Rengasamy, A., Ravichandran, L. V., Prostaglandin E2 receptors, effects in co- spontaneously hypertensive rats, Reikersdorfer, C. G. and Johns, lonic circular smooth muscle, in 1162 R. A.: Inhalational anesthetics do dog, 1008 modulation of spinal sympathetic not alter nitric oxide synthase ac- Prostaglandin F2,, receptors, radioligand reflex by, in rat, 380 tivity, 599 binding analysis, 285 [3H]RX 821002 vs [3Hlrauwolscine Reperfusion Prostaglandins binding, in nine tissues and cell effects of phenylephrine-induced pre- polymeric delivery, effects on systemic lines, 1287 conditioning on, in rat hearts, 689 availability and uterotonic activ- alpha-i, agonist preconditioning, in splanchnic, carvedilol effects in SAO ity, 1123 rat hearts, 689 shock in, in rat, 64 renal, role in cicletanine effects on kid- beta Reperfusion injury, sodium channel block- ney function, 1197 ade by class-I-type antiarrhyth- Protein C, activated, antiinflammatory ef- effects in SNS-evoked adrenal date- cholamine release, in anesthe- mid agents after, 1403 fects, in rat models, 193 Respiratory dysfunction, calcium-induced Protein phosphatase inhibitors, toxicity, tized dogs, 1337 signaling in brain, in rat, 415 mitochondrial, verapamil effects, 545 beta-2 206 Proteolysis effects in SNS-evoked adrenal cate- Retinoic acid, prevention of pretransla- calpain-mediated spectrin, induction in cholamine release, in anesthe- tional down regulation of P450 long-term hippocampal slices, 2Cii in vitamin A deficiency by, 902 tized dogs, 1337 salmeterol blockade of eosinophil in male rat liver, 427 neurotoxic induction, in long-term hip- inhibition by, 850 Reward, cocaine, sensitization to, 808 pocampal slices, 902 beta-i, effects in SNS-evoked adrenal Reynolds, E. E., Keiser, J. A., Haleen, S. Protzman, C. E., see Woodward, D. F., 285 catecholamine release, in anes- J., Walker, D. M., Olszewski, B., Psychostimulants, mRNA induction by, in thetized dogs, 1337 Schroeder, R. L., Taylor, D. G., rat forebrain, 909 cannabinoid, anandamide analog bind- Hwang, 0., Welch, K M., Flynn, PT’l’, see 2(3-Propanoyl-3f3-(4-tolyl) tropane ing, 1172 M. A., Thompson, D. M., Ed- Pulmonary artery, pharmacodynamics of muscarinic munds, J. J., Berryman, K A., 15-HPETE and 15-HETE in, in bladder subtypes, 959 Plummer, M., Cheng, X.-M., Patt, guinea pig and human, 1182 W. C., and Doherty, A. M.: Phar- Purinoceptors, facilitatory prejunctional, gallbladder muscle subtypes, 650 interaction with K channel blockers, macological characterization of on rabbit ear artery adrenergic effects on atrial repolarization, PD 156707, an orally active ETA nerves, 1390 1095 receptor antagonist, 1410 Puustinen, T., see Matsuda, H., 1182 regulation of cardiac CFTR Cl cur- RFL-6 fibroblast cells, secretion of cAMP Qiu, C., see Valentin, J.-P., 744 rent by, effects of quaternary am- and cGMP by, effects of nitric ox- Quaternary ammonium compounds, mus- monium compounds on, 470 ide on, 16 carinic regulation of cardiac role in cicletanine effects on kidney Rho, J. M., see Subramaniam, S., 878 CFTR C1 current by, 470 function, 1197 Rice, K. C., see Bilsky, E. J., 359 I 578 Index Vol. 273

Rice, K C., see Silverthorn, M. L., 213 seine, in nine tissues and cell lines, kindling, FPL 13950 effects against, Riezebos, J., see MacAllister, R. J., 154 1287 1023 Rifai, N., see Brugnara, C., 266 Ryan, W., see Adams, I. B., 1172 Self-administration, cocaine, role of delta Right heart failure, effects on hepatic oxy- opioid receptors in, in rhesus genation and theophylline clear- S 16118 monkeys, 1245 ance, in rats, 1332 BK B2 receptor antagonist effects, 1071 Sensi, S. L., see Lynch, J. J. III, 554 Rime!e, T. J., see Pate!, M. J., 16 effects in in vivo animal models of in- Sensitivity Rivet, J.-M., see Gobert, A., 1032 flammation, 1078 ethanol, prediction by zolpidem effects Rivet, J.-M., see Millan, M. J., 1418 Sadrzadeh, S. M. H., Meydani, M., Khet- on GABA-induced inhibition, in Ro 20-1724, effects on acid secretion, in try, U. and Nanji, A. A.: High- rat, 526 rabbit gastric glands, 1396 dose vitamin E supplementation to morphine-induced analgesia, adverse Robbiano, L., see Martelli, A., 113 has no effect on ethanol-induced effects of paternal opiates expo- Roberts, A. M., see Kim, C., 605 pathological liver injury, 455 sure on, 386 Robertson, D. W., see Gidda, J. S., 695 Sakai, M., see Hosakawa, M., 1313 neonatal opiate, in rat, 1353 Robineau, P., see F#{233}l#{233}tou,M., 1071, 1078 Sakamoto, M., see Brugnara, C., 266 Sensitization Rogawski, M. A. , see Subramaniam, S., Salmeterol, blockade ofbeta adrenergic in- cocaine, effects on neuronal responses to 878 hibition of eosinophil secretion glutamate in mesoaccumbens do- Rogers, T. J., see Belkowski, S. M., 1491 by, 850 pamine system, 445 Rolipram, effects on acid secretion, in rab- Salter, E. D., see Showell, H. J., 176 to conditioned rewarding effects of co- bit gastric glands, 1396 S#{225}nchez-Blazquez, P. and Garz#{244}n,J.: “N- caine, 808 Roppelt, C., see Pogue, D. H., 863 acetyl-13-endorphin-(1-3 1) dis- Sensory nerves, modulation of sympa- Rose, D. A., see Patel, M. J., 16 rupts the diminishing effect of thetic vasoconstriction by, in rat Rosenthal, G., see Conklin, J. L., 762 mastoparan on opioid- and irideal arterioles, 918 Rosenzweig-Lipson, S. , see Bergman, J., clonidine-evoked supraspinal an- Serkiz, B., see F#{233}l#{233}tou,M., 1071 40 tinociception in mice, 787 Serotonergic neurotoxicity, MDMA-in- Rost#{232}ne, W., see Betancur, C., 1450 Sandow, J., see Kertscher, U., 709 duced, L-deprenyl protective ef- Rotation, effects of repeated daily dopa- SAO, see Splanchmc artery occlusion fects against, 667 mine receptor agonist treatment Saponins, ginseng, reduction of ACh- Serotonin on, 1483 evoked Na influx and catechol- Rotert, G., see Anderson, D. J., 1434 amine secretion by, in bovine ad- in combination with TRH, microinjec- Rothman, R., see Yurdaydin, C., 185 renal chromaffin cells, 629 tion into nucleus raphe obscurus, Rothman, R. B., see Bilsky, E. J., 359 Sarau, H. M., see Chabot-Fletcher, M. C., effects on gastric motility, in rat, Rothman, R. B., see Silverthorn, M. L., 213 1147 499 RP 73870, anti-ulcer effects, in rat, 1015 Sarcoplasmic reticulum, skeletal muscle, GABA interactions in substantia nigra, R-PIA, see R-N-Phenylisopropyladenosine ‘251-radioiodinated myotoxin a modulation of MDMA-induced [‘251]RTI-55, binding sites for 5-HT trans- binding site properties in, 934 striatal dopamine release by, porter, demonstration of, in rat Sarre, S., see Deleu, D., 1323 1063 brain membranes, 213 Sato, R., see Yoshida, A., 702 MDMA-induced neurotoxicity, L-depre- Rubinraut, S., see Gozes, I., 161 Satoh, S., see Koganei, H., 1337 nyl protective effects against, 667 Rudy, A. C., Knight, P. M., Brater, D. C. SB 202235, effects in allergic asthma mod- potentiation of ethanol-induced excita- and Hall, S. D.: Enantioselective els, 1147 tion of ventral tegmental area disposition of ibuprofen in elderly SC-19220, effects in colonic circular neurons by, in rat brain slices, persons with and without renal smooth muscle, in dog, 1008 1139 impairment, 88 SC-53450, effects on SC-30249 systemic release of, induced by d-fenfluramine, Ruffin, J. S., see Aloyo, V. J., 435 availability and uterotonic activ- 643 Ruffolo, R. R., Jr., see Bril, A., 1264 ity, 1123 SerotoninlA autoreceptors Ruffolo, R. R., Jr., see Christopher, T. A., SC-30249, polymeric delivery, effects on modulation of, in rat, 1032 64 systemic availability and utero- modulation of central serotoninergic Ruffolo, R. R., Jr., see Yue, T.-L., 1442 tonic activity, 1123 neurons vs adrenergic and do- Ruggieri, M. R., see Wang, P., 959 Schedule-controlled behavior, effects of D1 paminergic neurons by, in rat, Runnegar, M. T., Maddatu, T., Deleve, L. and D2 receptor agonists on, in 1032 D., Berndt, N. and Govindarajan, squirrel monkeys, 40 Serotoninergic neurons, modulation by S.: Differential toxicity ofthe pro- Scheim, J. A., see O’Leary, E. C., 193 5-HT1A receptors, in rat, 1032 tein phosphatase inhibitors mi- Schmidt, R. E., see Gullikson, G. W., 1123 Serotothn,. receptors crocystin and calyculin A, 545 Schook, L. B., see Bradshaw, M., 1506 agonist modulation of DOl-induced Runyan, S., see Wang, H.-Y., 492 Schreiber, R., Brocco, M., Audinot, V., Gob- head-twitches in rat, 101 Ruscoe, J. E., Jewel!, H., Maggs, J. L., ert, A., Veiga, S. and Millan, M. J.: LY 165,163 agonist effects at, 1418 O’Neill, P. M., Storr, R. C., Ward, (l-(2,5-Dimethoxy-4 iodophenyl)-2- Serotomn2A receptors S. A. and Park, B. K: The effect of aminopropane)-induced head- mediation of DOl-induced head- chemical substitution on the met- twitches in the rat are mediated by twitches in rat by, 101 abolic activation, metabolic de- 5-hydroxytryptamine (5-HT) re- toxication, and pharmacological ceptors: Modulation by novel neurotransmission mediated by, melato- nm agonist modulation of, in rat, activity of amodiaquine in the 5-HT2AJ2c antagonists, D1 antago- mouse, 393 nists and 5-HT1A agonists, 101 304 Rush, C. R., Sullivan, J. T. and Griffiths, Schrier, R. W., see Koo, W.-S., 206 Serotonin2 receptors, antagonist mod- R. R. : Intravenous caffeine in Schroeder, R. L., see Reynolds, E. E., 1410 ulation of DOI-induced head- stimulant drug abusers: Subjec- Schwartz, P. J., see Zaza, A., 1095 twitches in rat, 101 tive reports and physiological ef- Scratching, dopamine D2 agonist effects, Serotonin receptors, effects in benzodiaz- fects, 351 pharmacological analysis, in epine-withdrawal-induced gastric Russel, F. G. M., see Snel, C. A. W., 1300 squirrel monkeys, 138 emptying disturbances, in rats, Ruthenium red, effects on voltage-sensi- Sebastian, A., see Jiang, Q., 680 995 tive Ca channels, 940 Seidler, F. J., see Wagner, J. P., 415 Serotonin4 receptors, hyperpolarization Rutherford, M. S., see Bradshaw, M., 1506 Seizures response, corticosterone modula- [3HIRX 821002, alpha-2-adrenoceptor bind- GHB-induced absence, endogenous tion of, in rat CAl hippocampal ing, comparison with [3H]rauwol- GABA in, in rat, 1534 pyramidal neurons, 1132 1995 Index I 579

Serotonin3 receptors, in blood-brain bar- SKF82958 ways in cat esophageal and lower rier, antagonist antiemetic ef- in combination with terguride, in treat- esophageal sphincter circular fects, in dogs, 695 ment of MPTP-lesioned parkinso- smooth muscle, 482 Serotonin transporters, [‘25I]RTI-55 bind- nian cynomolgus monkeys, 309 Soudijn, W., see Math#{244}t, R. A. A., 405 ing sites in rat brain membranes, effects on ventral pallidal neuronal ac- Spea!man, R. D., see Bergman, J., 40 demonstration of, 213 tivity, 516 Spectrin, calpain-mediated proteolysis, in- Serra, M., see Dazzi, L., 241 SKF38393, effects on ventral pallidal neu- duction by pathogenic treatments Serum albumin, role in nitric oxide dose- ronal activity, 516 in long-term hippocampal slices, response, in isolated perfused rat Skin, minoxidil sulfotransferase activities, 902 kidney, 855 in human, 582 5-PIA, see S-N6-Phenylisopropyladenosine Serum thyroxine, levels, reduction by Slotkin, T. A., see Wagner, J. P., 415 Spinal cord UDP-glucuronosyltransferase in- Small intestine benzodiazepine receptors in, heteroge- ducers, in rats, 977 cephalosporin transport in, in human, neity resolution with FASA and rat and rabbit, 26 Seyed-Mozaffari, A., see Jiang, Q., 680 LIGAND, in rat, 842 smooth muscle, GM-109 motilin antago- Shahabi, N. A. and Sharp, B. M.: Antipro- effects of morphine tolerance in CGRP- nist properties in, in rabbit, 624 liferative effects of S opioids on like immunostaining and recep- Smallwood, R. A., see Ng, C. Y., 1332 highly purified CD4 and CD8 tor binding sites in, in rat, 887 Smith, C. W., see Chrandasekhar, S., 1519 murine T cells, 1105 Spinal sympathetic reflex, alpha-2 modu- Smith, D. J., see Monroe, P. J., 1057 Sharp, B. M., see Shahabi, N. A., 1105 lation of, in rat, 380 Smith, D. L., see Monroe, P. J., 1057 Shebuski, R. J., see Virkhaus, R., 569 Splanchnic artery occlusion shock, carve- Smith, J. E., see Hemby, S. E., 591, 656 Shefner, S. A., see Brodie, M. S., 1139 dilol effects in, in rat, 64 Smooth muscle Shefner, S. A., see Pan, W. J., 537 Splanchnic ischemialreperfusion, carve- circular Shigemasa, C., see Yoshida, A., 702 dilol effects in SAO shock in, in colonic, PGE2 EP receptor effects in, rat, 64 Shirnoto, Y., see Miwa, H., 367 in dog, 1008 Shinozuka, K., see Ishii, R., 1390 Splanchnic nerve stimulation, adrenal cat- esophageal and lower esophageal echolamine release evoked by, ef- Shippenberg, T. S. and Heidbreder, Ch.: sphincter, signal transduction Sensitization to the conditioned fects of beta adrenoceptors in, in pathways in, in cat, 482 anesthetized dogs, 1337 rewarding effects of cocaine: small intestine, GM-i09 motilin antag- Spleen, uptake ofnartograstim by, in rats, Pharmacological and temporal onist properties in, in rabbit, 624 1114 characteristics, 808 [3H]a-trinositol binding sites in, autora- Spontaneous hypertension Shock diographic localization and char- rnedullary I 1-imidazoline and a2-adren- endotoxic, S 16118 effects in, in in vivo acterization of, in human and ergic receptors effects in, in con- animal models, 1078 mammalian tissues, 461 scious rats, 1162 splanchnic artery occlusion, carvedilol Smooth muscle cells renal effects of Ang II in, in young ge- effects in, in rat, 64 leukocyte adhesion to, carvedilol inhibi- netically hypertensive rats, 768 Showell, H. J., Pettipher, E. R., Cheng, J. tion of, 1442 Sprague, J. E. and Nichols, D. E.: The B., Breslow, R., Conklyn, M. J., vascular monoamine oxidase-B inhibitor L- Farrell, C. A., Hingorani, G. P., inhibition by (3-cyclodextrin tetra- deprenyl protects against 3,4- decasulfate, in human, 948 Salter, E. D., Hackman, B. C., methylenedioxymethamphet- Wimberly, D. J., Doherty, N. S., oxidation of low-density lipoproteins amine-induced lipid peroxidation Melvin, L. S., Jr., Reiter, L. A., by, carvedilol inhibition of, 1442 and long-term serotonergic defi- Biggers, M. S. and Koch, K.: The tetrandrine effects on, 32 cits, 667 SNC 80, nonpeptidic S-opioid agonist in vitro and in vivo pharmacologic SQ 28,603, modulation of AMP-dependent pharmacology, 359 activity of the potent and selec- endothelin effects by, 744 Snead, 0. C. III, see Banerjee, P. K., 1534 tive leukotriene B4 receptor an- [3H]SR 48692, binding sites, in guinea pig tagonist CP-105696, 176 Snel, C. A. W., Moons, M. M., Russel, F. G. M. and Mulder, G. J.: Disposition brain, 1450 SH-SY5Y cells, intact, opioid binding stud- Stagnitto, M. L., see Palmer, G. C., 1023 ies, 721 ofthe bromosulfophthalein-gluta- Starke, K., see Szabo, B., 128 Shuba, L. M., see Ogura, T., 1273 thione conjugate in the isolated perfused rat kidney, 1300 Stauber, K. L., Laskin, J. D., Yurkow, E. Silverthorn, M. L., Dersch, C. M., Bau- SNS, see Splanchnic nerve stimulation J., Thomas, P. E., Laskin, D. L. mann, M. H., Cadet, J. L., Par- and Conney, A. H.: Flow cytom- tilla, J. S., Rice, K. C., Carroll, F. Sodium ACh-evoked influx in adrenal chromaf- etry reveals subpopulations of I., Becketts, K. M., Brockington, fin cells, reduction by ginseng sa- murine epidermal cells that are A. and Rothman, R. B.: Studies of ponins, in bovine, 629 refractory to induction of cyto- the biogenic amine transporters. excretion of, effects of K channel chrome P-45OiAi by f3-naph- V. Demonstration of two binding blocker on, in conscious rats, 1375 thoflavone, 967 sites for the cocaine analog renal handling of, central kappa opioid Stearns, R. A., see Krieter, P. A., 816 [‘25I]RTI-55 associated with the effects on, 199 Stepp Patchin, D., see Elliott, W. C., 280 5-HT transporter in rat brain Sodium channel blockers, in combination Stimulant drug abusers, intravenous caf- membranes, 213 with glutamate receptor antago- feine in, subjective reports and Simpson, P. J., see O’Leary, E. C., 193 nists, reduction of oxygen-glucose physiological effects, 351 Simpson, P. J., see Virkhaus, R., 569 deprivation-induced cortical neu- Storr, R. C., see Ruscoe, J. E., 393 Simson, P. E., see Criswell, H. E., 526 ronal injury by, 554 Stress Singer, M., see Adams, I. B., 1172 Sodium channels, blockade by class-I-type activity, gastric lesions induced by, do- Singhal, P. C., see Mattana, J., 80 antiarrhythmic agents postisch- pamine Dl and D2 receptor ef- Sitar, D. S., see Escobar, M. R., 72 emia, 1403 fects in, in rats, 1001 Skeletal muscle Sodium nitroprusside, arteriovenous po- hippocampal acetylcholine and cortical L-dopa pharmacokinetics in, effects of tency and selectivity on human dopamine release induced by, carbidopa and entacapone on, in blood vessels, 154 modulation by abecarnil and imi- beagle dog, 1323 Sohn, U. D., Han, B., Tashjian, A. H., dazenil, in rat, 241 sarcoplasmic reticulum, ‘25I-radioiodi- Jr., Behar, J. and Biancani, P.: Striated muscle, capsaicin-induced dila- nated myotoxin a binding site Agonist-independent, muscle-type- tion of arterioles and venules in, properties in, 934 specific signal transduction path- in rat, 605 1580 Index Vol. 273

Stupienski, R. F. III, see Wallace, A. A., Takeo, S., Tanonaka, K., Hayashi, M., Thomas, G., Ito, K, Zikic, E., Bhatti, T., 168 Yamamoto, K., Liu, J.-X., Ka- Han, C. and Ramwell, P. W.: Spe- Subramaniam, S., Rho, J. M., Penix, L., miyama, T., Yamaguchi, N., cific inhibition of the contraction Donevan, S. D., Fielding, R. P. Miura, A. and Natsukawa, T.: A of the rat aorta by estradiol 17(3, and Rogawski, M. A.: Felbamate possible involvement of sodium 1544 block ofthe N-methyl-D-aspartate channel blockade of class-I-type Thomas, P. E., see Jayyosi, Z., 1156 receptor, 878 antiarrhythmic agents in post- Thomas, P. E., see Stauber, K L., 967 Substance P, vasodepressor effects in trac- ischemic contractile recovery of Thomas, S. B., see Anderson, D. J., 1434 tus solitarius nucleus, 617 isolated, perfused hearts, 1403 Thompson, D. M., see Reynolds, E. E., 1410 Substantia nigra Takeuchi, K., see Ishii, R., 1390 Thompson, D. M., Auta, J., Guidotti, A. 5-HT/GABA interactions in, modulation Takeuchi, T., see Tamai, I., 26 and Costa, E. : Imidazenil, a new of MDMA-induced striatal dopa- Takimoto, M., see Hosakawa, M., 1313 anxiolytic and anticonvulsant mine release by, 1063 Tamai, I., Tomizawa, N., Takeuchi, T., Na- drug, attenuates a benzodiaz- zona compacta dopamine neurons, aden- kayama, K., Higashida, H. and epine-induced cognition deficit in osine effects on, 576 Tsuji, A. : Functional expression monkeys, 1307 Sugiura, Y. , see Bowersox, S. S. , 248 of transporter for (3-lactam anti- Thoracic aorta, levcromakalim antago- Sugiyama, Y., see Kuwabara, T., 1114 biotics and dipeptides in Xenopus nism in, by glibenclamide ana- Sullivan, J. P., see Anderson, D. J., 1434 laevis oocytes injected with mes- logs, in rat, 778 Sullivan, J. T., see Rush, C. R., 351 senger RNA from human, rat and Thurieau, C., see F#{233}l#{233}tou,M., 1071, 1078 Superactive lipophilic peptides, VIP ana- rabbit small intestines, 26 Thyroid cells, G-protein and K channels logues, 161 Tamaki, T., see Hirano, T., 223 in, antiarrhythmic drug inhibi- Superoxide, suppression by PDE N inhib- Taniguchi, S., see Yoshida, A., 702 tion of, 702 itors, in guinea pig eosinophils, Tanonaka, K., see Takeo, S., 1403 Thyroid homeostasis, alteration by UDP- 674 Tashjian, A. H., Jr., see Sohn, U. D., 482 glucuronosyltransferase induc- Supraspinal antinociception, opioid/ Taste aversion conditioning, effects of an- ers, in rats, 977 clonidine, NAC-13-END effects on orectic and aversive agents on, in Thyroid-stimulating hormone mastoparan reduction of, in mice, rats, 1203 induction of cAMP by, effects of antiar- 787 Taylor, D. G., see Panek, R. L., 753 rhythmic drugs on, in thyroid Surber, B., see Anderson, D. J., 1434 Taylor, D. G., see Reynolds, E. E., 1410 cells, 702 Suzuki, T., see Kanda, T., 955 secretion of, UDP-glucuronosyltrans- T cells Swelling, calcium-induced mitochondrial, ferase inducer effects on, in rats, CD4, antiproliferative effects of S opi- verapamil effects, 206 977 oids on, in mice, 1105 Swinyard, E. A., see Palmer, G. C., 1023 Thyrotopin-release hormone, in combina- CD8, antiproliferative effects of S opi- Swiss 3T3 cells, FP receptor subtype ra- tion with serotonin, microinjec- oids on, in mice, 1105 dioligand binding analysis, in rat, tion into nucleus raphe obscurus, cytotoxic, alloantigen-specific activity, 285 effects on gastric motility, in rat, effects of exogenous corticoste- Sympathetic nervous system, cocaine ef- 499 rone on, in mice, 823 fects on, in conscious rabbits, 128 Thyroxine TCV-116, effects on gene expression of Sympathetic reflex, spinal, alpha-2 modu- glucuronidation of, UDP-glucuronosyl- TGF-(31 and extracellular matrix, lation of, in rat, 380 transferase inducer effects on, in in cardiac and vascular tissues of Sympathetic vasoconstriction, modulation rats, 977 hypertensive rats, 509 by sensory nerves and NO, in rat serum levels, reduction by UDP-glucu- Tedisamil, cardiac electrophysiologic and irideal arterioles, 918 ronosyltransferase inducers, in antiarrhythmic actions of, 168 Synaptic current, GABAB-mediated, pre- rats, 977 Tegmentum, paramedian midbrain, be- synaptic inhibition by adenosine, Ticher, A., see Gozes, I., 161 in midbrain dopamine neurons, havioral and neurochemical ef- Tirelli, E. and Witkin, J. M.: Differential 576 fects of opioids in, 327 effects ofdirect and indirect dopa- Szabo, B., Obergfell, A. and Starke, K: Terguride, in combination with SKF mine agonists on the induction of Involvement of monoamine up- 82958, in treatment of MPTP- gnawing in C57B1/6J mice, 7 take inhibition and local anesthe- lesioned parkinsonian cynomol- Tiriveedhi, S., see Bahr, B. A., 902 sia in the cardiovascular response gus monkeys, 309 Tissue thiols, content during nitroglycerin to cocaine in conscious rabbits, 128 9-Tetrahydrocannabinol tolerance, in rats, 94 anandamide cross-tolerance, 1235 T lymphocytes, see T cells Tachikawa, E., Kudo, K., Kashimoto, T. antinociceptive effects, anandamide a-Tocopherol, supplementation, effects on and Takahashi, E.: Ginseng sa- blockade of, in mice, 1235 ethanol-induced liver damage, ponins reduce acetylcholine- z6-Tetrahydrocannabinol, modulation of 455 evoke Na influx and catechol- macrophage antigen processing Tolerance amine secretion in bovine adrenal by, 1216 morphine chromaffin cells, 629 Tetrandrine, effects on vascular smooth effects in CGRP-like immunostaining Tail-flick test muscle cells, 32 and receptor binding sites, in rat buprenorphine antagonism of mu opi- Thalamus, ventrobasal nucleus of, presyn- spinal cord, 887 oids in, in rhesus monkey, 1345 aptic GHB and GABAB receptor- prevention of, with irreversible j.t opi- opiate mediation of antinociceptive ef- mediated release of GABA and oid antagonists, 680 fects of noxious thermal stimula- glutamate in, in rat, 1534 mu opiate, ontogency of, in rat, 1361 tion of one hindpaw on, in rat, THC, see Tetrahydrocannabinol nitroglycerin, tissue thiols content dur- 1428 Theophylline, hepatic clearance, effects of ing, in rats, 94 Takahashi, E., see Tachikawa, E., 629 right heart failure on, in rats, opioid Takahashi, T., see Hasler, W. L., 344 1332 dynorphin A modulation of, 292 Takai, K., see Kuwabara, T., 1114 Thioacetamide, fulminant hepatic failure in human placenta, 987 Takanashi, H., Yogo, K., Ozaki, K.-I., induced by, opioid peptide brain to repeated daily dopamine receptor Ikuta, M., Akima, M., Koga, H. and plasma levels with, in rats, agonists, 1483 and Nabata, H.: GM-109: A novel, 185 Toll, L.: Intact cell binding and the rela- selective motilin receptor antago- Thiols, tissue, content during nitroglyc- tion to opioid activities in SH- nist in the smooth muscle of the em tolerance, in rats, 94 SY5Y cells, 721 rabbit small intestine, 624 Thomas, B. F., see Adams, I. B., 1172 Tomizawa, N., see Tamai, I., 26 1995 Index 1581

Torphy, T. J., see Barnette, M. S., 674, U50,488H, modulation ofmacrophages by, Ventrobasal nucleus of thalamus, presyn- 1396 1491 aptic GHB and GABAB receptor- Tosaki, A., Engelman, D. T., Engelman, R. Ulcers mediated release of GABA and M. and Das, D. K:Alpha-l adren- activity stress, dopamine Dl and D2 re- glutamate in, in rat, 1534 ergic receptor agonist-induced ceptor effects in, in rats, 1001 Venules, capsaicin-induced dilation of, in preconditioning in isolated work- RP 73870 effects against, in rat, 1015 rat striated muscle, 605 ing rat hearts, 689 Umbilical cord, [3H]a-trinositol binding Verapamil Toxicity sites in, autoradiographic local- effects against calcium-induced mito- acetaminophen, in human CYP2E1- ization and characterization of, in chondrial injury, 206 transfected HepG2 cells, 1497 human tissues, 461 effects on blood-brain barrier transport calpain, induction in long-term hip- Underwood, D. C., see Chabot-Fletcher, M. of peptides, in rats, 298 pocampal slices, 902 C., 1147 Villa, P., see F#{233}l#{233}tou,M., 1078 dapsone, in G6PD-deficient erythro- Ungerstedt, U., see Carter, A. J., 637 VIP, see Vasoactive intestinal peptide cytes, in rat, 870 Urade, Y., see Hosakawa, M., 1313 Virkhaus, R., Lucchesi, B. R., Simpson, P. 5-HT, MDMA-induced, L-deprenyl pro- Urinary bladder, muscarinic receptor sub- J. and Shebuski, R. J.: The role of tective effects against, 667 types, 959 adhesion molecules in cardiovas- hydralazine, testing of, 113 Urine, calcium concentrations, effects and cular pharmacology: Meeting re- protein phosphatase inhibitor, 545 interactions of gentamicin, pol- view, 569 Tracey, W. R., Nakane, M., Kuk, J., yaspartic acid and diuretics on, Vita, A. J., see Mu#{241}oz,N. M., 850 Budzik, B., Klinghofer, V., Har- 280 Vitamin A deficiency, pretranslation down ris, R. and Carter, G.: The nitric Uterus, contractile effects of SC-30249 on, regulation of P450 2Cll in, pre- oxide synthase inhibitor, LNG. effects of SC-53450, 1123 vention by ATRA, in male rat monomethylarginine, reduces liver, 427 Valentin, J.-P., Qiu, C., Wiedemann, E., carrageenan-induced pleurisy in Vitamin B 12a, see Hydroxocobalamin Gardner, D. G. and Humphreys, the rat, 1295 Vitamin E, supplementation, effects on M. H.: Modulation of ANP-depen- Tractus solitarius, nucleus of, vasodepres- ethanol-induced liver damage, dent effects of endothelin by in- sor effects of substance P in, 617 455 hibitors of neutral endopeptidase Transforming growth factor-131, gene ex- Volland, J.-P., see F#{233}l#{233}tou,M., 1071 and cGMP phosphodiesterase, pression, AT1 receptor antagonist Voltage-sensitive calcium channels 744 effects on, in cardiac and vascular blockade by w-conopeptides and w-aga- Vallance, P., see MacAllister, R. J., 154 tissues of hypertensive rats, 509 toxin-NA, at mouse neuromuscu- Vallebuona, F., see Raiteri, M., 643 Trifunovic, R. D., see Brodie, M. S., 1139 lar junction, 248 Van Den Aarsen, B. C. F. M., see Math#{244}t, Triglycerides, y-linolenic acid-containing, ruthenium red effects on, 940 R. A. A., 405 effects on nerve conduction and Voltage-sensitive potassium A-currents, van Rossum, D., see M#{233}nard,D. P., 887 blood flow in diabetic rats, 49 modulation by cannabinoids, in Vascular smooth muscle cells Trimellitic anhydride, allergic response hippocampal neurons, 734 induced by, role of complement inhibition by 13-cyclodextrin tetradeca- Volume expansion, renal excretory effects, sulfate, in human, 948 system in, in lung, 793 central kappa opioid effects on, [3HJa-Trinositol, binding sites, autoradio- oxidation oflow-density lipoproteins by, 199 carvedilol inhibition of, 1442 graphic localization and charac- Vonk, R., see Little, J. M., 1551 tetrandrine effects on, 32 terization of, in human and mam- VSMCs, see Vascular smooth muscle cells Vasoactive intestinal peptide, superactive malian tissues, 461 Vyas, S. J. and Jackson, E. K.: Angiotensin lipophilic peptide analogues, 161 Tropane cocaine analog, effects on nucleus II: Enhanced renal responsive- Vasoconstriction accumbens extracellular dopa- ness in young genetically hyper- estradiol 17(3 inhibition of, in rat aorta, mine concentration and motor ac- tensive rats, 768 1544 tivity, 656 sympathetic, modulation by sensory Wagner, J. P., Seidler, F. J., Lappi, S. E., TSH, see Thyroid-stimulating hormone nerves and NO, in rat irideal ar- McCook, E. C. and Slotkin, T. A.: Tsuji, A., see Tamai, I., 26 terioles, 918 Role of presynaptic input in the Tsujimura, A., see Katsura, M., 1529 Vasodepression, substance P, in tractus ontogeny of adrenergic cell sig- Tsukada, H., see Hosakawa, M., 1313 solitarius nucleus, 617 naling in rat brain: Beta recep- Tsukagoshi, H., Haddad, E.-B., Barnes, P. Vasodilation tors, adenylate cyclase and c-los J. and Chung, K. F.: Bradykinin capsaicin-induced, in rat striated mus- protooncogene expression, 415 receptor subtypes in rat lung: Ef- cle, 605 Wagner, R. A., see Zakharov, S. I., 470 fect of interleukin-1f3, 1257 jejunal arteriole, regulation by capsa- Walker, D. M., see Reynolds, E. E., 1410 Tumor necrosis factor-a, inhibition of icin-sensitive nerves, in N. brasil- Walker, E. A., Zernig, G. and Woods, J. H.: adenosine analogue, 1506 iensis-sensitized rats, 337 Buprenorphine antagonism of mu opioid, in macrophages, 1491 Veiga, S., see Schreiber, R., 101 opioids in the rhesus monkey tail- Tyr-D-Ala-Gly-MePhe-Gly(ol)-enkephalin, Vela, G., see Betancur, C., 1450 withdrawal procedure, 1345 see DAMGO Ventilation, effects ofcaffeine and nicotine Wallace, A. A., Stupienski, R. F. III, U37883A on, in rhesus monkeys, 1085 Baskin, E. P., Appleby, S. D., effects on glomerular filtration rate and Ventral pallidum, neuronal activity, ef- Kothstein, T., Gehret, J. R., King, electrolyte excretion, in conscious fects of D1 agonists on, 516 S. W., Remy, D. C. and Lynch, J. rats, 1375 Ventral tegmental area J., Jr.: Cardiac electrophysiologic effects on renal tubule function and K behavioral and neurochemical effects of and antiarrhythmic actions of te- channel activity, 1382 opioids in, 327 disamil, 168 Uchimura, T., see Kuwabara, T., 1114 dopamine neurons in, adenosine effects Walsh, D. A., Mapp, P. I., Polak, J. M. and UDP-glucuronosyltransferase inducers, on, 576 Blake, D. R.: Autoradiographic lo- thyroid homeostasis alteration ethanol excitation of, serotonin potenti- calization and characterization of by, in rats, 977 ation of, in rat brain slices, 1139 [3H]a-trinositol (iD-myo-inositol UDP-glycosyltransferases, human liver, Ventricular arrhythmias, tedisamil effects 1,2,6-trisphosphate) binding sites characterization of, with photoaf- against, 168 in human and mammalian tis- finity analogs, 1551 Ventricular myocytes, dimethyl sulfoxide sues, 461 Ueda, S., see Hosakawa, M., 1313 effects on action potentials, ionic Wang, H.-Y., Runyan, S., Yadin, E. and Ueta, Y., see Yoshida, A., 702 currents and cell water in, in Friedman, E. : Prenatal exposure UGTs, see UDP-glycosyltransferases guinea pig preparations, 1273 to cocaine selectively reduces D1 1582 Index Vol. 273

dopamine receptor-mediated acti- Windh, R. T., Little, P. J. and Kuhn, C. M.: Yogo, K, see Takanashi, H., 624 vation of striatal Gs proteins, 492 The ontogeny of mu opiate toler- Yoshida, A., Hisatome, I., Kotake, H., Wang, J. Q. and McGinty, J. F.: Dose- ance and dependence in the rat: Hirai, S., Taniguchi, S., Oyaizu, dependent alteration in zi/’/268 Antinociceptive and biochemical M., Sato, R., Kouchi, T., Ueta, Y., and preprodynorphin mRNA ex- studies, 1361 Mitani, Y., Ahmmed, G. U., pression induced by amphet- Winkler, J. D., see Chabot-Fletcher, M. C., Nawada, T., Shigemasa, C. and amine or methamphetamine in 1147 Mashiba, H.: Antiarrhythmic rat forebrain, 909 Wirtshafter, D., see Klitenick, M. A., 327 drugs inhibit the G-protein and Wang, P., Luthin, G. R. and Ruggieri, M. Wiseman, J. S., see Patel, M. J., 16 K channels in the cultured thy- R. : Muscarinic acetylcholine re- Withdrawal roid cell line, 702 ceptor subtypes mediating uri- benzodiazepine, gastric emptying dis- Yoshino, T., see Nomura, K., 1001 nary bladder contractility and turbance induced by, in rats, 995 Yu, P., see Chen, Q., 650 coupling to GTP binding proteins, ethanol, effects on cerebral diazepam Yu, S. P., see Lynch, J. J. III, 554 959 binding inhibitor mRNA levels, in Yue, T.-L., see Christopher, T. A., 64 Wang, T., see Bilsky, E. J., 359 mice, 1529 Yue, T.-L., Wang, X., Gu, J.-L., Ruffolo, R. Wang, T., Wang, W.-H., Klein-Robben- opioid, dynorphin A modulation of, 292 R., Jr. and Feuerstein, G. Z.: haar, G. and Giebisch, G.: Effects Witkin, J. M., see Pell#{243}n,R., 138 Carvedilol, a new vasodilating be- of a novel KATP channel blocker Witkin, J. M., see Pirelli, E., 7 ta-adrenoceptor blocker, inhibits on renal tubule function and K Wolf, M. E., see White, F. J., 445 oxidation of low-density lipopro- channel activity, 1382 Wong, D. T., see Gidda, J. S., 695 teins by vascular smooth muscle Wang, W.-H., see Wang, T., 1382 Woodhead, J. H., see Palmer, G. C., 1023 cells and prevents leukocyte ad- Wang, X., see Yue, T.-L., 1442 Woods, J. H., see Walker, E. A., 1345 hesion to smooth muscle cells, Wang, Y.-Y., Yeung, J. P. and Friedman, Woodward, D. F., Fairbairn, C. E., Krauss, 1442 E. : Prenatal cocaine exposure se- A. H-P., Lawrence, R. A. and Pro- lectively reduces mesocortical do- Yukimura, T., see Kim, S., 509 tzman, C. E.: Radioligand binding pamine release, 1211 Yurdaydin, C., Li, Y., Ha, J.-H., Jones, E. analysis of receptor subtypes in Ward, S. A., see Ruscoe, J. E., 393 A., Rothman, R. and Basile, A. S.: two FP receptor preparations Wasicak, J., see Anderson, D. J., 1434 Brain and plasma levels of opioid that exhibit different functional Water, renal handling of, central kappa peptides are altered in rats with rank orders of potency in re- opioid effects on, 199 thioacetamide-induced fulminant sponse to prostaglandins, 285 Weiss, M., see Mu#{241}oz,N. M., 850 hepatic failure: Implications for Weisz, P. B., see Okada, S. S., 948 Wright, R. N., see Eison, A. S., 304 the treatment of hepatic enceph- Welch, K. M., see Reynolds, E. E., 1410 Writhing assay, naloxone-insensitive an- alopathy with opioid antagonists, Welch, S. P., Dunlow, L. D., Patrick, G. S. tinociceptive effects of dynorphin 185 and Razdan, R K: Characteriza- A-(2-17) in, 802 Yurkow, E. J., see Stauber, K L., 967 tion of anandamide- and fluoro- Wu, Y.-N., Mercuri, N. B. and Johnson, S. W. : Presynaptic inhibition of anandamide-induced antinocicep- Zakharov, S. I., Wagner, R. A. and Harvey, -y-aminobutyric acidB-mediated tion and cross-tolerance to 9-ThC R. D.: Muscarinic regulation of synaptic current by adenosine re- after intrathecal administration to the cardiac CFTR Cl current corded in vitro in midbrain dopa- mice: Blockade of 9-ThC-induced by quaternary ammonium corn- mine neurons, 576 antinociception, 1235 pounds, 470 Westbrooks, K. L., see Buccafusco, J. J., Wypij, D. M., see Patel, M. J., 16 Zamah, R., see Cemerikic, B., 987 1162 Zaprinast, modulation of AMP-dependent White, F. J., Hu, X.-T., Zhang, X.-F. and Xenopus laevis oocytes, injected with endothelin effects by, 744 Wolf, M. E.: Repeated adminis- mRNA from human, rat and rab- Zatarain, J. M., see Greenberg, S. S., 257 tration of cocaine or amphet- bit small intestines, functional Zaza, A., Malfatto, G. and Schwartz, P. J.: amine alters neuronal responses expression of f3-lactam antibiotic Effects on atrial repolarization of to glutamate in the mesoaccum- and dipeptide transporter in, 26 the interaction between K chan- bens dopamine system, 445 Xie, J., see Greenberg, S. S., 257 nel blockers and muscarinic re- White, H. S., see Palmer, G. C., 1023 Whyte, A., see Deadwyler, S. A., 734 ceptor stimulation, 1095 Zernig, G., see Walker, E. A., 1345 Widdowson, P., see F#{233}l#{233}tou,M., 1071 Yadin, E., see Wang, H.-Y., 492 Wiedemann, E., see Valentin, J.-P., 744 Yamada, T., see Miwa, H., 367 Zhang, X.-F., see White, F. J., 445 Willer, J.-C., see Guirimand, F., 830 Yamaguchi, I., see Nomura, K., 1001 Zhou, L.-X., Finley, D. K., Hassell, A. E. Williams, M., see Anderson, D. J., 1434 Yamaguchi, M., see Akai, T., 309 and Holtzman, J. L.: Pharmacoki- Wimberly, D. J., see Showell, H. J., 176 Yamaguchi, N., see Takeo, S., 1403 netic interaction between isradip- WIN 35,428 Yamamoto, B. K., Nash, J. F. and Gudel- me and lovastatin in normal, fe- binding in caudate nucleus, in rabbit, sky, G. A.: Modulation of methyl- male and male volunteers, 121 435 enedioxymethamphetamine- zil/268, mRNA expression, dose-related soluble binding, in primate striatum, induced striatal dopamine re- effects of amphetamine or meth- 1224 lease by the interaction between amphetamine on, in rat fore- Windh, R. T. and Kuhn, C. M.: Increased serotonin and y-aminobutyric brain, 909 sensitivity to mu opiate antinoci- acid in the substantia nigra, 1063 Zikic, E., see Thomas, G., 1544 ception in the neonatal rat de- Yamamoto, K., see Takeo, S., 1403 Zolpidem, effects on GABA-induced inhibi- spite weaker receptor-guanyl nu- Yang, H.-H., see Liu-Chen, L.-Y., 1047 tion, prediction of ethanol-GABA cleotide binding protein coupling, Yashpal, K., see Pitcher, G. M., 1428 interaction by, in rat brain re- 1353 Yeung, J. 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