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Contribution a L'étude D'une Plante Médicinale Et Aromatique Myrtus Communis L

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Contribution a L'étude D'une Plante Médicinale Et Aromatique Myrtus Communis L CONTRIBUTION A L’ÉTUDE D’UNE PLANTE MÉDICINALE ET AROMATIQUE MYRTUS COMMUNIS L. Amel Bouzabata To cite this version: Amel Bouzabata. CONTRIBUTION A L’ÉTUDE D’UNE PLANTE MÉDICINALE ET AROMA- TIQUE MYRTUS COMMUNIS L.. Sciences pharmaceutiques. Faculté de Médecine, Université Badji-Mokhtar, Annaba, Algérie., 2015. Français. tel-01493134 HAL Id: tel-01493134 https://tel.archives-ouvertes.fr/tel-01493134 Submitted on 23 Mar 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. République Algérienne Démocratique et Populaire MINISTERE DE L’ENSEIGNEMENT SUPERIEUR ET DE LA RECHERCHE SCIENTIFIQUE Université Badji Mokhtar Annaba Faculté de Médecine *********************** Thèse présentée pour obtenir le diplôme de Doctorat en Sciences Médicales Discipline : Sciences Pharmaceutiques Mention : «Pharmacognosie» CONTRIBUTION A L’ETUDE D’UNE PLANTE MEDICINALE ET AROMATIQUE MYRTUS COMMUNIS L. Présentée par AMEL BOUZABATA Directeur de thèse : Pr. LAHOUARI ABED, Professeur en Pharmacognosie, Faculté de Médecine, Université Benyoucef Benkhedda, Alger. Algérie Membres du jury : Président de jury : Pr. MAZOUZ DEKHIL, Professeur en Microbiologie Médicale, Faculté de Médecine, Université Badji-Mokhtar, Annaba. Algérie Pr. FELIX TOMI, Professeur en Chimie Analytique, Université de Corse. France. Pr. YOUCEF HADEF, Professeur en Chimie Analytique, Faculté de Médecine, Université Badji-Mokhtar, Annaba. Algérie. Pr. DALILA SMATI, Professeur en Botanique Médicale, Faculté de Médecine, Université Benyoucef Benkhedda, Alger. Algérie. N° d’ordre : T.1586 Annaba, soutenue le 17 juin 2015 DEDICACES «En vérité, le Chemin importe peu, la volonté d’arriver suffit à tout». Albert Camus. «A la mémoire de mon grand père». «A mes parents pour leurs encouragements, et leur soutien». «A toutes mes sœurs, à mon frère, et à tous les membres de ma famille». I REMERCIEMENTS Ce travail de thèse a été financé par le Ministère de l’Enseignement Supérieur et de la Recherche Scientifique dans le cadre de la coopération interuniversitaire Franco-Algérienne sous le programme «PROFAS B». En tête de ces remerciements, je tiens à rendre hommage à la défunte Madame le Professeur Faffani Boussaha, qui a guidé mes premiers pas dans la réalisation de cette thèse. Qu’elle repose en paix. Je remercie Monsieur le Professeur Lahouari Abed pour la confiance qu’il m’a accordée en acceptant de remplacer la défunte Mme le Professeur Faffani Boussaha, pour ses précieux conseils et son écoute tout au long de mon parcours universitaire. Je tiens également à exprimer ma profonde reconnaissance à Monsieur le Professeur Félix Tomi, pour m’avoir accueillie dans son équipe au sein du laboratoire de Chimie et de Biomasse, CNRS-UMR 6134, et pour m’avoir donné l’opportunité de me former en Phytochimie avec des appareils modernes. J’ai été très sensible à sa grande disponibilité et à la confiance qu’il a bien voulu m’accorder. Je tiens à adresser mes plus vifs remerciements au Professeur Joseph Casanova pour son dévouement incomparable et nos nombreuses entrevues enrichissantes. Il m’a inculqué l’importance de la rigueur scientifique. Sans lui, cette thèse n’aura pas été la même. Professeur, je vous suis éternellement reconnaissante, pour m’avoir donné l’espoir et le courage de m’améliorer de jour en jour. Que Dieu vous garde. J’aimerais également citer les personnes dont la collaboration a été essentielle pour plusieurs aspects de ce travail. Je remercie en particulier Madame le Professeur Ligia Salgueiro, et Madame le Docteur Celia Cabral de l’Université de Coimbra, Portugal pour leurs conseils et leur aide concernant la réalisation des tests antifongiques e tdes tests anti-inflammatoires. Mes remerciements vont également à Monsieur le Professeur Ange Bighelli (Université de Corse) ainsi qu’à Monsieur Vincent Castola (Maître de Conférences à l’Université de Corse). Je suis sensible à l’honneur que me fait Monsieur le Professeur Dekhil Mazouz de présider le jury de cette thèse. Je remercie également Monsieur le Professeur Hadef Youcef, Madame le Professeur Smati Dalila, en acceptant d’être les rapporteurs de ce travail. Je suis très heureuse de bénéficier de leurs recommandations et je tiens à leur exprimer ma sincère reconnaissance pour le temps accordé à l’évaluation de ce travail de thèse. Je remercie également Monsieur Taoufik Mouhoubi de l’Institut Forestier de Bainem, Alger, et Monsieur Abdelhamid Chebli Ingénieur en Agronomie à l’Institut Forestier de Tamanrasset. Je remercie également Monsieur Messaoud Betina, directeur de la société ExtraBio, pour son aide précieuse. II Je remercie également tous mes chefs hiérarchiques pour avoir été à l’écoute à tout moment. Je remercie également tout l’ensemble administratif de la faculté de Médecine Université Badji-Mokhtar. A Mesdames Marie- Catherine Lugrezi, et Marie-Christine Bosquets, personnels CNRS du laboratoire une vive reconnaissance pour leur gentillesse. Je remercie également l’ensemble des doctorants de l’Université de Corse, pour leur sympathie au sein du laboratoire. Enfin, je ne saurais terminer sans remercier ma mère, une amie et une confidente qui m’a soutenu dans mes choix et a su toujours m’encourager quelques que soient les difficultés que j’ai pu rencontrer dans mon travail. III LISTE DES TRAVAUX. LISTE DES PUBLICATIONS. 1- Bouzabata A., Boussaha F., Casanova J., Tomi F., 2010. Composition and Chemical Variability of leaf oil of Myrtus communis L. from North-Eastern Algeria. Natural Product Communications 5 (10): 1659-1662. 2- Bouzabata A., Castola V., Abed L., Bighelli A., Casanova, J., Tomi F., 2013. Chemical Variability of Algerian Myrtus communis L. Chemistry and Biodiversity 10 (1): 129-137. 3- Bouzabata, A., 2013. Traditional Treatement for Diabetes and High Blood Pressure in Souk Ahras District. Journal of Pharmacognosy and Phytotherapy 5 (1): 12-20. 4- Bouzabata A., Bazzali O., Cabral C., Gonçalves M.J., Cruz M.T., Bighelli A., Cavaleiro, C., Casanova, J., Salgueiro, L., Tomi, F., 2013. New coumpounds, chemical composition, antifungal activity and cytotoxicity of the essential oil from Myrtus nivellei Batt. & Trab. an endemic species of Central Sahara. Journal of Ethnopharmacology 149: 613-620. 5- Bouzabata A., Cabral C., Gonçalves M.J., Cruz M.T., Bighelli A., Cavaleiro C., Casanova J., Tomi F., Salgueiro L., 2015. Myrtus communis L. as source of bioactive and safe essential oil. Food and Chemical Toxicology 75: 166-172. LISTE DES COMMUNICATIONS. 1- Bouzabata A., Boussaha F. Contribution à l’étude d’une plante médicinale et aromatique Myrtus communis L. Congrès International sur les Plantes Médicinales et Aromatiques CIPAM 26, 27 et 28 mars 2009. Université Cadi Ayyad Marrakech. 2- Bouzabata A., Boussaha F., Casanova J., Tomi F. Composition of Myrtus communisL. essential oil from North-Eastern Algeria.Symposium International d’Aromathérapie et Plantes Médicinales Palais des Congrès de Grasse. 26, 27 et 28 mars 2010. 3- Bouzabata A., Boussaha F., Casanova J., Tomi F. Variability of the Yield and the Chemical of Essential oils of Myrtus communis L. coming from three stations of Algeria. 3ième Symposium France Pakistan. 4ièmeJournées Internationale de l’AFERP, 15 au 18 juillet 2010, Université de Franche-Compté, Besançon, France. 4- Bouzabata A., Boussaha F., Casanova J., Tomi F. Place d’une plante médicinale méditerranéenne Myrtus communis L. dans la médecine traditionnelle algérienne. 3ième Symposium France Pakistan Journées Internationale de l’AFERP, 15 au 18 juillet 2010, Université de Franche-Compté, Besançon, France. 5- Bouzabata A., Bazzali O., Bighelli A., Casanova J., Tomi F. Myrtus communis L. leaf essential oil from Algeria. Congrès International sur les Plantes Médicinales et Aromatiques CIPAM 13,14 et 15 avril 2011, Cagliari. 6- Bouzabata A., Bazzali O., Bighelli A., Casanova J., Tomi F. Essential Oil from Myrtus nivellei Batt. & Trab. an endemic species of Sahara. Congrès International sur les Plantes Médicinales et Aromatiques CIPAM 13,14 et 15 avril 2011, Cagliari. 7- Bouzabata A., Casanova J., Bighelli A., Abed L., Tomi F. Myrtus communis L. from Algeria: Chemical Composition and Variability. 43rd International Symposium on Essential Oils ISEO 5 à 8 septembre 2012, Lisbonne, Portugal. 8- Bouzabata A., Cabral C., Cruz T., Casanova J., Bighelli A., Cavaleiro C., Abed L., Salgueiro L., Tomi F. Anti-inflammatory Activity and Cytotoxicity of Myrtus communis L. Essential Oil from Algeria. 44 rd International Symposium on Essential Oils ISEO 8 à 12 septembre 2013; Budapest, Hongrie. IV 9- Bouzabata A., Bazzali O., Cabral C., Cruz T., Casanova J., Bighelli A., Cavaleiro C., Abed L., Salgueiro L., Tomi F. The genus Myrtus in Algeria: Composition and Biological Activities of essential oils: A review. Congrès sur les Plantes Médicinales et Aromatiques CIPAM 17, 18, 19, 20 Mars 2014, Djerba; Tunisie. 9- Bouzabata A., Abed L., Casanova J., Bighelli A., Tomi F. Composition and Chemical Variability of Eucalyptus bosistoana F.Muell. Essential Oil from Algerian Sahara. Congrès sur les Plantes Médicinales et Aromatiques CIPAM 17, 18, 19,
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