Nutrients for Immune Support
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TRP Channels in Visceral Pain
Send Orders of Reprints at [email protected] 23 The Open Pain Journal, 2013, 6, (Suppl 1: M4) 23-30 Open Access TRP Channels in Visceral Pain L. Ashley Blackshaw*,1,2, Stuart M. Brierley2, Andrea M. Harrington2 and Patrick A. Hughes2 1Wingate Institute for Neurogastroenterology, Centre for Digestive Diseases, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London; 2Nerve-Gut Research Laboratory, Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia 5000. Abstract: Visceral pain is both different and similar to somatic pain - different in being poorly localized and usually referred elsewhere to the body wall, but similar in many of the molecular mechanisms it employs (like TRP channels) and the specialization of afferent endings to detect painful stimuli. TRPV1 is sensitive to low pH. pH is lowest in gastric juice, which may cause severe pain when exposed to the oesophageal mucosa, and probably works via TRPV1. TRPV1 is found in afferent fibres throughout the viscera, and the TRPV1 agonist capsaicin can recapitulate symptoms experienced in disease. TRPV1 is also involved in normal mechanosensory function in the gut. Roles for TRPV4 and TRPA1 have also been described in visceral afferents, and TRPV4 is highly enriched in them, where it plays a major role in both mechanonociception and chemonociception. It may provide a visceral-specific nociceptor target for drug development. TRPA1 is also involved in mechano-and chemosensory function, but not as selectively as TRPV4. TRPA1 is colocalized with TRPV1 in visceral afferents, where they influence each other’s function. -
Product List Active Botanical Ingredients from Nature’S Wealth to Better Health
PRODUCT LIST ACTIVE BOTANICAL INGREDIENTS FROM NATURE’S WEALTH TO BETTER HEALTH At Finzelberg, state-of-the-art processes meet revered tradition. Since 1875, we have served as a reliable, steadfast partner to renowned pharmaceutical and healthcare companies, producing active botanical ingredients of the highest quality. We always move forward with a spirit of long-term collaboration and mutual respect — between customers, suppliers and our employees. Raising the bar of efficacy and excellence. We offer a broad portfolio of independently certified premium botanical extracts for herbal medicinal products and dietary supplements — for tablets and capsules, as well as for other innovative dosage forms. Delivering quality you can trust. By applying the highest standards from seeds to finished extracts, we ensure consistent quality and minimized risk through the entire value chain. Our process-oriented, integrated management system is continuously subject to certification. Being part of a strong group. We’re a proud member of the nature network® — allowing us to control our botanical supply and offer high-quality products that are traceable back to the origins. Acting globally. As a global player, we are at home all over the world — with more than 25 sales and manufacturing sites within the nature network®. Beyond that, we cooperate with many trusted sales partners within an even broader network. Making new ideas happen. For us, there’s nothing more satisfying than finding the optimal solution for a customer’s specific need. We consistently invest in new ideas and clinical studies that support the efficacy of our products. 2 PAGE 4–5 COUGH & COLD PAGE 6 CENTRAL NERVOUS SYSTEM SPORTS, JOINT & ENERGY PAGE 7 PAGE 8–9 MEN’S HEALTH & WOMEN’S HEALTH HEART & VEINS PAGE 10 DIGESTION PAGE 11 Creating active botanical ingredients for efficacious results. -
COVID-19: Is There Evidence for the Use of Herbal Medicines As Adjuvant Symptomatic Therapy?
REVIEW published: 23 September 2020 doi: 10.3389/fphar.2020.581840 COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy? † † Daˆ maris Silveira 1* , Jose Maria Prieto-Garcia 2* , Fabio Boylan 3, Omar Estrada 4, Yris Maria Fonseca-Bazzo 1, Claudia Masrouah Jamal 5,Pe´ rola Oliveira Magalhães 1, † Edson Oliveira Pereira 1, Michal Tomczyk 6 and Michael Heinrich 7* 1 Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia, Brazil, 2 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom, 3 School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 4 Biophysics and Biochemistry Center, Venezuelan Institute of Scientific Research, Caracas, Venezuela, 5 Center of Health Sciences, Federal Edited by: University of Espirito Santo, Vito´ ria, Brazil, 6 Faculty of Pharmacy, Medical University of Bialystok, Bialystok, Poland, Valentina Echeverria Moran, 7 Pharmacognosy and Phytotherapy, School of Pharmacy, University College of London, London, United Kingdom Bay Pines VA Healthcare System, United States Reviewed by: Background: Current recommendations for the self-management of SARS-Cov-2 Helen Skaltsa, disease (COVID-19) include self-isolation, rest, hydration, and the use of NSAID in case National and Kapodistrian University of Athens, Greece of high fever only. It is expected that many patients will add other symptomatic/adjuvant Franc¸ois Chassagne, treatments, such as herbal medicines. Emory University, United States Aims: To provide a benefits/risks assessment of selected herbal medicines traditionally *Correspondence: “ ” Daˆ maris Silveira indicated for respiratory diseases within the current frame of the COVID-19 pandemic as [email protected] an adjuvant treatment. -
Agroforestry Opportunities Mid-West, Lake States and New England Northeast Ohio Windbreak Program
Agroforestry Opportunities Mid-West, Lake States and New England Northeast Ohio Windbreak Program Key Points 17 NW counties 10 acres and 1,000 row feet Landowner pays $0.34 per row foot (2013) 1-6 rows of trees and shrubs Trends: protect crops and improve wildlife habitat 2013 Windbreak Planting Season Summary 9 new windbreaks were planted in six counties totaling 75,172 row feet (14.2 miles), covering approximately 33 acres. 8,435 seedlings were used to plant new windbreaks: 4,415 conifers 4,020 hardwoods & shrubs Approximately 110 seedlings were used for windbreak replacements. 7 planting days were needed from April 1 through April 8, and May 8, 2013. One planting crew was used with Division of Forestry personnel. Ohio Mushroom workshops – OSU Extension Ohio Maple Producers Association Northwest Ohio Windbreak Program – crop and homestead windbreaks Rural Action –Athens, OH Roots of Appalachia Growers Association - medicinals Wisconsin Alley cropping Windbreaks Maple syrup Silvopasture Forest Farming Mid-West Hazelnut Growers Conference – March 2014 Entomoforestry trees and insects Nectar Sources Alders Willows Maples Fruit trees Tulip Poplar Black Locust Basswood Asters Berries Clover Aquaforestry trees and aquaculture Illinois Windbreaks and riparian buffers – mainly through CRP Alley cropping, NTFPs, Silvopasture gaining some interest Mid-American Agroforestry Working Group (MAAWG)– Training Academy, MN July Maple syrup – many producers, no organized association Missouri Windbreaks Mushrooms Missouri -
Professional Herbalist Consultation
tinctures PROFESSIONAL Our tincture pricing applies to the vast majority of our herbs. Some of the few exceptions include our mushroom tinctures. HERBALIST Bulk tincture packages are available to qualified practitioners who wish to stock their dispensary from us. Please contact us for more details. CONSULTATION herb pricing Initial Consultation We offer dried herbs in a maximum of the items you are interested in for a 100g increments. You may purchase as quote of our current stock. $120.00 little or as much as you like. Some of HERBS AND If our menu does not have what you our herbs are offered in powder form. Followup Visits are looking for, we encourage you to Our herbs change frequently, as do contact us. We will do our utmost to their prices. Please email or call us with serve you. $40.00 The above fees do not include herbal Tincture pricing remedies or supplements TINCTURES 500 ml 250 ml 125 ml Skype & Phone consultations are available $86 $44 $24 Discounts are offered for students. Latin Name Common Name Latin Name Common Name Latin Name Common Name Latin Name Common Name Acacia concinna Shikakai Cordyceps sinensis Cordyceps Juniperis communis Juniper Rhaponticum carthamoides Maral Root Achillea millefollium Yarrow Corydalis spp. Yan Hu Suo Lactuca virosa Wild Lettuce Rheum palmatum Turkey Rhubarb Crataegus oxycanthoides fructus Hawthorne berry Larrea tridentata Chaparral Acmella oleracea Toothache Plant Rhodiola rosea Golden Root Crataegus oxycanthoides folium Hawthorne leaf & flower Lavendula spp. Lavender Acorus calamus Sweet -
Diterpenoids As Potential Anti-Malarial Compounds from Andrographis Paniculata Manish Kumar Dwivedi, Shringika Mishra, Shruti Sonter and Prashant Kumar Singh*
Dwivedi et al. Beni-Suef University Journal of Basic and Applied Sciences Beni-Suef University Journal of (2021) 10:7 https://doi.org/10.1186/s43088-021-00098-8 Basic and Applied Sciences RESEARCH Open Access Diterpenoids as potential anti-malarial compounds from Andrographis paniculata Manish Kumar Dwivedi, Shringika Mishra, Shruti Sonter and Prashant Kumar Singh* Abstract Background: The objectives of the current study are to evaluate the traditionally used medicinal plants Andrographis paniculata for in vitro anti-malarial activity against human malarial parasite Plasmodium falciparum and to further characterize the anti-malarial active extract of A. paniculata using spectroscopic and chromatographic methods. Results: The chloroform extract of A. paniculata displayed anti-malarial activity with IC50 values 6.36 μg/ml against 3D7 strain and 5.24 μg/ml against K1 strains respectively with no evidence of significant cytotoxicity against mammalian cell line (CC50 > 100 μg/ml). LC-MS analysis of the extract led to the identification of 59 compounds based on their chromatographic and mass spectrometric features (a total of 35 compounds are present in positive ion and 24 compounds in negative ion mode). We have identified 5 flavonoids and 30 compounds as diterpenoids in positive ion mode, while in the negative mode all identified compounds were diterpenoids. Characterization of the most promising class of compound diterpenoids using HPLC-LC-ESI-MS/MS was also undertaken. Conclusions: The in vitro results undoubtedly validate the traditional use of A. paniculata for the treatment of malaria. The results have led to the identification of diterpenoids from IGNTU_06 extract as potential anti-malarial compounds that need to be further purified and analyzed in anti-malarial drug development programs. -
Review Article Systematic Review of the Use of Phytochemicals for Management of Pain in Cancer Therapy
Hindawi Publishing Corporation BioMed Research International Volume 2015, Article ID 506327, 8 pages http://dx.doi.org/10.1155/2015/506327 Review Article Systematic Review of the Use of Phytochemicals for Management of Pain in Cancer Therapy Andrew M. Harrison,1 Fabrice Heritier,2 Bennett G. Childs,3 J. Michael Bostwick,4 and Mikhail A. Dziadzko5 1 Medical Scientist Training Program, Mayo Clinic, Rochester, MN 55905, USA 2Department of Anesthesiology, CH du Forez, 42600 Montbrison, France 3Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, USA 4Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN 55905, USA 5Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA Correspondence should be addressed to Mikhail A. Dziadzko; [email protected] Received 10 August 2015; Accepted 1 October 2015 Academic Editor: Sung-Hoon Kim Copyright © 2015 Andrew M. Harrison et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Pain in cancer therapy is a common condition and there is a need for new options in therapeutic management. While phyto- chemicals have been proposed as one pain management solution, knowledge of their utility is limited. The objective of this study was to perform a systematic review of the biomedical literature for the use of phytochemicals for management of cancer therapy pain in human subjects. Of an initial database search of 1,603 abstracts, 32 full-text articles were eligible for further assessment. Only 7 of these articles met all inclusion criteria for this systematic review. -
Autohydrolysis of Lentinus Edodes for Obtaining Extracts with Antiradical Properties
foods Article Autohydrolysis of Lentinus edodes for Obtaining Extracts with Antiradical Properties Liceth Rocío Huamán-Leandro 1 , María Jesús González-Muñoz 1,2 , Catalina Fernández-de-Ana 3, Arturo Rodríguez-Blanco 3, María Dolores Torres 1,2,* and Herminia Domínguez 1,2 1 Departamento de Enxeñería Química, Universidade de Vigo (Campus Ourense), Edificio Politécnico, As Lagoas, 32004 Ourense, Spain; [email protected] (L.R.H.-L.); [email protected] (M.J.G.-M.); [email protected] (H.D.) 2 CITI-Universidade de Vigo, Tecnopole, San Cibrao das Viñas, 32901 Ourense, Spain 3 Hifas da Terra SL, Portamuiños,7, 36154 Bora Pontevedra, Spain; [email protected] (C.F.-d.-A.); [email protected] (A.R.-B.) * Correspondence: [email protected]; Tel.: +34-988-387-075 Received: 7 November 2019; Accepted: 3 January 2020; Published: 9 January 2020 Abstract: The autohydrolysis of Lentinus edodes was proposed for the extraction of components with antioxidant properties. Operation under non-isothermal conditions was evaluated and compared with isothermal heating. The influence of process severity was assessed in the range of 0.18 to 4.89 (temperature between 50 and 250 ◦C), up to 80% (d.b.) The influence of process severity during the autohydrolysis of Lentinus edodes was assessed in the range 0.3 to 4.89 (temperature between 50 and − 250 ◦C). Up to 80% (d.b.) of the initial raw material could be solubilized at 210 ◦C. The different behavior of the saccharide and phenolic fractions was observed with the treatment temperature. Whereas the highest concentration of the saccharide components (mainly glucooligosaccharides) was found at 210 ◦C, the maximum phenolic yield was identified at 250 ◦C. -
An Evaluation of Western Herbal Complementary Medicine Labelling
An evaluation of Western Herbal Complementary Medicine labelling in South Africa, to determine whether the product labelling information complies with established herbal monographs and whether it meets local regulatory requirements Joanna Antonia TYMBIOS M.Sc. Pharmacy Administration and Policy Regulation Oct 2013 Cohort University of the Western Cape November 2015 Research project submitted in partial fulfilment of the requirements for the degree of M.Sc. in Pharmacy Administration and Policy Regulation 1 Title An evaluation of Western Herbal Complementary Medicine labelling in South Africa, to determine whether the product labelling information complies with established herbal monographs and whether it meets local regulatory requirements 2 Abstract INTRODUCTION Complementary Medicines (CMs) are widely available to the South African public. However, CMs have not yet been evaluated by the Medicines Control Council (MCC). The MCC has published new guidelines for the regulation of CMs, with which CM companies are required to comply. OBJECTIVE Determine to what degree Western Herbal CM labelling complies with the MCC’s requirements. METHODS Thirteen CM products containing recognised Western Herbal ingredients were selected from pharmacies in the northern suburbs of Johannesburg. Labelling information on the immediate and outer container labels, as well as the package inserts, was investigated. The relevant corresponding European Medicines Agency (EMA) monographs and MCC guidelines were used to assess compliance. RESULTS None of the products complied with the product dosage section of the monographs. Furthermore, the products contained indications that were not present in the monographs. The products did not fully meet the MCC’s mandatory minimum 3 labelling requirements, and they did not demonstrate total compliance with all of the MCC’s requirements for product labels and package inserts. -
Special Forest Product Markets in the Pacific Northwest with Global Implications
Chapter 3 Special forest product markets in the Pacific Northwest with global implications Keith A. Blatner Associate Professor Department of Natural Resource Sciences Washington State University Pullman, WA 99164-6410 would like to first give credit to my colleague who has worked with me I on many of these projects. Bill Schlosser was my former graduate student at the University of Idaho. He is now at Michigan State University and shortly will be a USAID employee in Khabarovsk in the Russian Far East. He and I researched special forest products together for about 6 or 7 years. In the course of today’s presentation, I’m going to focus primarily on products from the Pacific Northwest—major products, their markets, and economic contribution. However, I’m going to digress at various times to show the international flavor of this market. There is a growing industry on the eastside of the Cascades, where I work. In fact, many of the products that are harvested on the eastside currently are marketed and processed through westside processors, a phenomenon that is slowly changing. There are large international markets for a variety of products. The special forest products industry consists of several specialized industries. The floral greens industry uses wild-harvested evergreen plant materials in floral arrangements. Typically, these plants are flexible and have long-lasting properties so they can be used in fresh or dried arrangements, often as background material. Moss is used as covering for the base of arrangements, or in pots or baskets. Christmas ornamentals are bough products, primarily cones, that are used in Christmas wreaths, swags, and door charms. -
Pelargoniums an Herb Society of America Guide
Pelargoniums An Herb Society of America Guide The Herb Society of America 9019 Kirtland Chardon Rd. Kirtland, Ohio 44094 © 2006 The Herb Society of America Pelargoniums: An Herb Society of America Guide Table of Contents Introduction …………………………………………………………….…. 3 Contributors & Acknowledgements ……………………………………… 3 Description & Taxonomy ..………………………………………………... 8 Chemistry …………………………………………………………………. 10 Nutrition …………………………………………………………………... 10 History & Folklore ………………………………………………………… 10 Literature & Art …………………………………………………………… 12 Cultivation ………………………………………………………………… 13 Pests & Diseases …………………………………………………………... 19 Pruning & Harvesting ……………………………………………………… 20 Preserving & Storing ………………………………………………………. 21 Uses ………………………………………………………………………... 21 - Culinary Uses ………………………………………………… 21 - Recipes ………………………………………………… 23 - Craft Uses ……………………………………………………. 40 - Cosmetic Uses ……………………………………………….. 41 - Recipes ……………………………………………….. 42 - Medicinal & Ethnobotanical Uses & Aromatherapy ………... 43 - Garden Uses ………………………………………………….. 47 - Other Uses …………………………………………………... 48 Species Highlights …..……………………………………………………… 49 Cultivar Examples …………………………………………………………. 57 Literature Citations & References ………………………………………... 62 HSA Library Pelargonium Resources …...………………………………… 68 © The Herb Society of America - 9019 Kirtland Chardon Rd., Kirtland, OH, 44094 - (440) 256-0514 - http://www.herbsociety.org 2 Pelargoniums: An Herb Society of America Guide Introduction Mission: The Herb Society of America is dedicated to promoting the knowledge, use and delight of -
WO 2007/095718 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date PCT (10) International Publication Number 30 August 2007 (30.08.2007) WO 2007/095718 Al (51) International Patent Classification: 5S2 (CA). THOMAS, Megan [CA/CA]; 5100 Spectrum A61K 31/197 (2006.01) A61K 33/42 (2006.01) Way, Mississauga, Ontario L4W 5S2 (CA). A61K 31/185 (2006.01) A61K 36/18 (2006.01) A61K 31/7004 (2006.01) (74) Agent: Torys LLP; 3000-79 Wellington Street West, Box 270, TD Centre, Toronto, Ontario M5K 1N2 (CA). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/CA2006/001512 kind of national protection available): AE, AG, AL, AM, AT,AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, (22) International Filing Date: CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, 14 September 2006 (14.09.2006) GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, (25) Filing Language: English LU, LV,LY,MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW (30) Priority Data: 60/776,325 23 February 2006 (23.02.2006) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): NEW GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, CELL FORMULATIONS LTD.