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Sylvia Wassertheil-Smoller Jordan Smoller Biostatistics and Epidemiology A Primer for Health and Biomedical Professionals Fourth Edition Biostatistics and Epidemiology Fourth Edition Sylvia Wassertheil-Smoller Department of Epidemiology, Albert Einstein College of Medicine, Bronx, NY, USA Jordan Smoller Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA Biostatistics and Epidemiology A Primer for Health and Biomedical Professionals Fourth Edition With 37 Illustrations Sylvia Wassertheil-Smoller Jordan Smoller Department of Epidemiology Department of Psychiatry and Center Albert Einstein College of Medicine for Human Genetic Research Bronx, NY, USA Massachusetts General Hospital Boston, MA, USA ISBN 978-1-4939-2133-1 ISBN 978-1-4939-2134-8 (eBook) DOI 10.1007/978-1-4939-2134-8 Library of Congress Control Number: 2014952775 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 1990, 1995, 2004, 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) To Alexis and Ava PREFACE TO THE FOURTH EDITION This book, through its several editions, has continued to adapt to evolving areas of research in epidemiology and statistics, while maintaining the orig- inal objective of being non-threatening, understandable and accessible to those with limited or no background in mathematics. New areas are covered in the fourth edition, and include a new chapter on risk prediction, risk reclassification and evaluation of biomarkers, new material on propensity analyses and a vastly expanded and updated chapter on genetic epidemiology. With the sequencing of the human genome, there has been a flowering of research into the genetic basis of health and disease, and especially the interactions between genes and environmental exposures. The medical liter- ature in genetic epidemiology is vastly expanding and some knowledge of the epidemiological designs and an acquaintance with the statistical methods used in such research is necessary in order to be able to appreciate new findings. Thus this edition includes a new chapter on genetic epidemiology. Such material is not usually found in first level epidemiology or statistics books, but it is presented here in a basic, and hopefully easily comprehensi- ble, way for those unfamiliar or only slightly familiar with the field. Another new chapter is on risk prediction, which is important both from an individual clinical perspective to assess patient risk in order to institute appropriate preventive measures, and from a public health per- spective to assess the needs of a population. As we get a better under- standing of the biology involved in diseases processes, new biomarkers of disease are being investigated either to predict disease or to serve as targets for new therapeutic measures. It is important to evaluate such biomarkers to see whether they actually improve the prediction of risk beyond that obtained from traditional risk factors. The new chapter explains the logic and statistical techniques used for such evaluations. The randomized clinical trial is the “gold standard” for evidence on causation and on comparing treatments. However, we are not able to do clinical trials in all areas, either due to feasibility issues, high costs or sample size and length of follow-up time required to draw valid conclusions. Thus we must often rely on evidence from observational studies that may vii viii Preface to the Fourth Edition be subject to confounding. Propensity analysis is an analytical technique increasingly used to control for confounding, and the 4th edition provides a comprehensive explanation of the methods involved. New material has also been added to several existing chapters. The principal objectives of the earlier editions still apply. The pre- sentation of the material is aimed to give an understanding of the under- lying principles, as well as practical guidelines of “how to do it” and “how to interpret it.” The topics included are those that are most commonly used or referred to in the literature. There are some features to note that may aid the reader in the use of this book: (a) The book starts with a discussion of the philosophy and logic of science and the underlying principles of testing what we believe against the reality of our experiences. While such a discussion, per se, will not help the reader to actually “do a t-test,” we think it is important to provide some introduction to the underlying framework of the field of epidemiol- ogy and statistics, to understand why we do what we do. (b) Many of the subsections stand alone; that is, the reader can turn to the topic that interests him or her and read the material out of sequential order. Thus, the book may be used by those who need it for special purposes. The reader is free to skip those topics that are not of interest without being too much hampered in further reading. As a result there is some redundancy. In our teaching experience, however, we have found that it is better to err on the side of redundancy than on the side of sparsity. (c) Cross-references to other relevant sections are included when addi- tional explanation is needed. When development of a topic is beyond the scope of this text, the reader is referred to other books that deal with the material in more depth or on a higher mathematical level. A list of recommended texts is provided near the end of the book. (d) The appendices provide sample calculations for various statistics described in the text. This makes for smoother reading of the text, while providing the reader with more specific instructions on how actually to do some of the calculations. Preface to the Fourth Edition ix The prior editions grew from feedback from students who indicated they appreciated the clarity and the focus on topics specifically related to their work. However, some users missed coverage of several important topics. Accordingly, sections were added to include a full chapter on measures of quality of life and various psychological scales, which are increasingly used in clinical studies; an expansion of the chapter on probability, with the introduction of several nonparametric methods; the clarification of some concepts that were more tersely addressed previ- ously; and the addition of several appendices (providing sample calcula- tions of the Fisher’s exact test, Kruskal–Wallis test, and various indices of reliability and responsiveness of scales used in quality of life measures). It requires a delicate balance to keep the book concise and basic, and yet make it sufficiently inclusive to be useful to a wide audience. We hope this book will be useful to diverse groups of people in the health field, as well as to those in related areas. The material is intended for: (1) physi- cians doing clinical research as well as for those doing basic research; (2) students—medical, college, and graduate; (3) research staff in various capacities; (4) those interested in the growing field of genetic epidemiol- ogy and wanting to be able to read genetic research or wishing to collab- orate in genetic research; and (5) anyone interested in the logic and methodology of biostatistics, epidemiology, and genetic epidemiology. The principles and methods described here are applicable to various substantive areas, including medicine, public health, psychology, and education. Of course, not all topics that are specifically relevant to each of these disciplines can be covered in this short text. Bronx, NY, USA Sylvia Wassertheil-Smoller Boston, MA, USA Jordan W. Smoller ACKNOWLEDGEMENTS I want to express my gratitude for the inspired teaching of Dr. Jacob Cohen, now deceased, who started me on this path and to my colleagues and students at the Albert Einstein College of Medicine, who make it fun. My appreciation goes to those colleagues who critiqued the earlier editions, and special thanks go to Dr. Aileen McGinn, Dr. Gloria Ho, Dr. Tao Wang and Dr. Kenny Ye for their help in editing the new material in this edition and for their always wise suggestions. Sadly, my late husband, Walter Austerer, is not here to enjoy this new edition, but I wish to honor his memory and the patience, love and support he unfailingly gave through previous editions.

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