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Of Pharmacy and Pharmacology Volume 12 Number 3, 22 January, 2018 ISSN 1996-0816 African Journal of Pharmacy and Pharmacology Volume 12 Number 3, 22 January, 2018 ISSN 1996-0816 ABOUT AJPP The African Journal of Pharmacy and Pharmacology (AJPP) is published weekly (one volume per year) by Academic Journals. African Journal of Pharmacy and Pharmacology (AJPP) is an open access journal that provides rapid publication (weekly) of articles in all areas of Pharmaceutical Science such as Pharmaceutical Microbiology, Pharmaceutical Raw Material Science, Formulations, Molecular modeling, Health sector Reforms, Drug Delivery, Pharmacokinetics and Pharmacodynamics, Pharmacognosy, Social and Administrative Pharmacy, Pharmaceutics and Pharmaceutical Microbiology, Herbal Medicines research, Pharmaceutical Raw Materials development/utilization, Novel drug delivery systems, Polymer/Cosmetic Science, Food/Drug Interaction, Herbal drugs evaluation, Physical Pharmaceutics, Medication management, Cosmetic Science, pharmaceuticals, pharmacology, pharmaceutical research etc. The Journal welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published shortly after acceptance. All articles published in AJPP are peer-reviewed. Contact Us Editorial Office: [email protected] Help Desk: [email protected] Website: http://www.academicjournals.org/journal/AJPP Submit manuscript online http://ms.academicjournals.me/ Editors Associate Editors Himanshu Gupta Department of Pharmacy Practice Dr. B. Ravishankar University of Toledo SDM Centre for Ayurveda and Allied Sciences, Toledo, OH SDM College of Ayurveda Campus, USA. Karnataka India. Prof. Zhe-Sheng Chen College of Pharmacy and Health Sciences Dr. Natchimuthu Karmegam St. John's University Department of Botany, New York, Government Arts College, USA. Tamil Nadu, India. Dr. Huma Ikram Neurochemistry and Biochemical Dr. Manal Moustafa Zaki Neuropharmacology Research Unit, Department of Veterinary Hygiene and Department of Biochemistry, Management University of Karachi Faculty of Veterinary Medicine, Karachi-75270 Cairo University Pakistan Giza, Egypt. Dr. Shreesh Kumar Ojha Molecular Cardiovascular Research Program Prof. George G. Nomikos College of Medicine Takeda Global Research & Development Center Arizona Health Sciences Center USA. University of Arizona Arizona, Prof. Mahmoud Mohamed El-Mas USA. Department of Pharmacology, Faculty of Pharmacy Dr. Vitor Engracia Valenti University of Alexandria, Departamento de Fonoaudiologia Alexandria, Faculdade de Filosofia e Ciências, Egypt. UNESP Brazil. Dr. Kiran K. Akula Electrophysiology & Neuropharmacology Research Unit Dr. Caroline Wagner Department of Biology & Biochemistry Universidade Federal do Pampa University of Houston Avenida Pedro Anunciação Houston, TX Brazil. USA. Dr. Ravi Shankar Shukla Macromolecule and Vaccine Stabilization Center Department of Pharmaceutical Chemistry University of Kansas USA. Editorial Board Prof. Fen Jicai Dr. Sirajunnisa Razack School of life science, Xinjiang University, Department of Chemical Engineering, Annamalai China. University, Annamalai Nagar, Tamilnadu, Dr. Ana Laura Nicoletti Carvalho India. Av. Dr. Arnaldo, 455, São Paulo, SP. Brazil. Prof. Ehab S. EL Desoky Professor of pharmacology, Faculty of Medicine Dr. Ming-hui Zhao Assiut University, Assiut, Professor of Medicine Egypt. Director of Renal Division, Department of Medicine Peking University First Hospital Dr. Yakisich, J. Sebastian Beijing 100034 Assistant Professor, Department of Clinical Neuroscience PR. China. R54 Karolinska University Hospital, Huddinge Prof. Ji Junjun 141 86 Stockholm , Guangdong Cardiovascular Institute, Guangdong General Sweden. Hospital, Guangdong Academy of Medical Sciences, China. Prof. Dr. Andrei N. Tchernitchin Head, Laboratory of Experimental Endocrinology and Prof. Yan Zhang Environmental Pathology LEEPA Faculty of Engineering and Applied Science, University of Chile Medical School, Memorial University of Newfoundland, Chile. Canada. Dr. Sirajunnisa Razack Dr. Naoufel Madani Department of Chemical Engineering, Medical Intensive Care Unit Annamalai University, Annamalai Nagar, Tamilnadu, University hospital Ibn Sina, Univesity Mohamed V India. Souissi, Rabat, Morocco. Dr. Yasar Tatar Marmara Unıversıty, Dr. Dong Hui Turkey. Department of Gynaecology and Obstetrics, the 1st hospital, NanFang University, Dr Nafisa Hassan Ali China. Assistant Professor, Dow institude of medical technology Dow University of Health Sciences,Chand bbi Road, Karachi, Prof. Ma Hui Pakistan. School of Medicine, Lanzhou University, China. Dr. Krishnan Namboori P. K. Computational Chemistry Group, Computational Prof. Gu HuiJun Engineering and Networking, School of Medicine, Taizhou university, Amrita Vishwa Vidyapeetham, Amritanagar, Coimbatore- China. 641 112 India. Dr. Chan Kim Wei Research Officer Prof. Osman Ghani Laboratory of Molecular Biomedicine, University of Sargodha, Institute of Bioscience, Universiti Putra, Pakistan. Malaysia. Dr. Liu Xiaoji Dr. Fen Cun School of Medicine, Shihezi University, Professor, Department of Pharmacology, Xinjiang China. University, China. African Journal of Pharmacy and Pharmacology Table of Contents: Volume 12 Number 3 22 January, 2018 ARTICL ES Traditional medicinal plants used for the treatment of diabetes in the Sudan: A review 27 Sakina M. Yagi and Ahmed I. Yagi Comparative evaluation of caffeine content in Arabian coffee with other caffeine beverages Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family:: Lythraceae) 41 Elizabeth A. Guzmán-Hernández, David Segura-Cobos, Dante Amato, José Guillermo Ávila-Acevedo and Beatriz Vázquez-Cruz Vol. 12(3), pp. 27-40, 22 January, 2018 DOI: 10.5897/AJPP2017.4878 Article Number: 256B39C55838 African Journal of Pharmacy and ISSN 1996-0816 Copyright © 2018 Pharmacology Author(s) retain the copyright of this article http://www.academicjournals.org/AJPP Review Traditional medicinal plants used for the treatment of diabetes in the Sudan: A review Sakina M. Yagi1* and Ahmed I. Yagi2 1Department of Botany, Faculty of Science, University of Khartoum, Khartoum, Sudan. 2Department of Health of Heath Sciences, Khawarizimi International College, United Arab Emirates. Received 16 December, 2017; Accepted 18 January, 2018 The prevalence of metabolic disorders such as diabetes among population is of increasing concern worldwide. Sudan is a developing country, where several areas frequently depend on folk medicine. Several herbal preparations have been used in folklore practice in Sudan for the management of diabetes with claims asserting their hypoglycemic effect. Basic research relating to these plants are reviewed in this paper with the intention to highlight their therapeutic potential for the treatment of diabetes and promote their regular use in Sudan. Ethnobotanical information was obtained by an assessment of the available literature in electronic data bases with publications describing the medicinal plants used for the treatment of diabetes. In this review paper, different parts of 38 plant species, are described that are used in the Sudanese traditional medicine and belong to 35 genera and 23 families. Thirty three plants have been documented in scientific literature to possess in vivo antidiabetic activity and only one was ineffective in lowering blood glucose level, namely Striga hermonthica. Many of the plants in the study review have been studied in in vitro models (such as α- amylase or α-glucosidase inhibition) in an effort to explain some of their biomedical interaction. The role of isolated bioactive compounds like trigonelline and 3, 5-dicaffeoylquinic acid in diabetes management is also evaluated in the present review. Ten plants original from Sudan have been already used in clinical trials for the treatment of type 2 diabetes. This review provides useful information on the characterization of such herbal medicines that are utilized in the Sudanese traditional medicine for the control of metabolic syndromes such as diabetes. Key words: Diabetes, Sudan, ethnopharmacology, pharmacology, toxicology. INTRODUCTION Diabetes is a metabolic disorder characterized by chronic Insufficient insulin secretion caused by immune hyperglycemia which results from insulin deficient destruction of pancreatic β-cells are vital for insulin secretion or impaired cellular action of the hormone. secretion and consequent development of insulin- *Corresponding author. E-mail: [email protected]. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License 28 Afr. J. Pharm. Pharmacol. dependent diabetes (Type 1). In case of abnormal insulin Traditional medicinal plants for the control of cellular action, type-2 diabetes is developed due to a diabetes gradual development of insulin resistance and pancreatic β-cell dysfunction. Symptoms are worsen due to obesity Data about the use of plants in folklore medicine for the and lack of physical activity by the sedentary lifestyle control of diabetes relates either with previously (Gutch et al., 2014). conducted ethnobotanical studies or published papers Diabetes prevalence is on the rise worldwide as a demonstrating the antidiabetic impact of certain plants in result of accumulating risk factors well pronounced in Sudan. The experimental evidence of the antidiabetic economically growing nations. An estimated 69% rise is activity is highlighted in this review, along with observed for the prevalence of the disease
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