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(12) United States Patent (10) Patent No.: US 6,746,695 B1 Martin Et Al
USOO6746695B1 (12) United States Patent (10) Patent No.: US 6,746,695 B1 Martin et al. (45) Date of Patent: Jun. 8, 2004 (54) PHARMACEUTICAL PREPARATIONS OF Abad, MJ et al., Anti-inflammatory activity of some medici BOACTIVE SUBSTANCES EXTRACTED nal plant extracts from Venezuela. J. Ethnopharmacol1996 FROM NATURAL SOURCES Dec;55(1):63–8. Alarcon-Aguilara, FJ, et al., Study of the anti-hyperglyce (75) Inventors: Michael Z. Martin, Laupahoehoe, HI mic effect of plants used as antidiabetics. J. Ethnopharmacol (US); Mehdi Ashraf-Khorassani, Blacksburg, VA (US); Larry Taylor, 612:101-110 (1998). Blacksburg, VA (US) Almeida CE et al., Analysis of anti-diarrheic effect of plants used in popular medicine. Rev Saude Publica 1995 (73) Assignees: Armadillo Pharmaceuticals, Inc., Dec;29(6):428-33. Armocas, CA (US); Virginia Tech. Alves KB, et al., Inhibition of aminopeptidase activity by Intellectual Properties, Inc., aromatic and other cyclic compounds. Braz, J Med Biol Res. Blackburg, VA (US) 1992:25(11):1103–6. (*) Notice: Subject to any disclaimer, the term of this Anesini C, et al., Screening of plants used in Argentine folk patent is extended or adjusted under 35 medicine for anti-microbial activity. J Ethnopharmacol. U.S.C. 154(b) by 0 days. 1993 Jun;39(2):119–28. Arletti, R, et al., Stimulating property of Turnera diffusa and Pfafia paniculata eXtracts on the Sexual behavior of male (21) Appl. No.: 09/578,849 rats, Psychopharmacology (Berl). 1999 Mar;143(1): 15-9. (22) Filed: May 26, 2000 Auterhoff, Het al., Constituents of the drug Damiana. Arch Related U.S. -
Pharmacologyonline 3: 817-823 (2006) Guzmàn Et Al
Pharmacologyonline 3: 817-823 (2006) Guzmàn et al. ANTIHYPERTENSIVE EFFECT OF Heimia salicifolia (H.B.K.) ALKALOIDS. Guzmán Hernández E, Segura-Cobos D, De Haro R, Vázquez-Cruz B. Laboratorio de Farmacología. UIICSE, FES-Iztacala. UNAM. Los Reyes Iztacala. Tlalnepantla, Estado de México 54090, México. Summary In order to evaluate the effects produced by the alkaloids of leaves from H. salicifolia on the blood pressure of rats, four alkaloids from H. salicifolia were isolated by column and thin layer chromatography. The alkaloids’ antihypertensive effects on angiotensin II-caused acute hypertension as well as their hypotensive effects on normotensive rats were studied. The alkaloid 3, the most abundant isolated alkaloid, turned out to be the most effective, while the other alkaloids showed a slight, non-significant vascular activity. Their mixture showed an additive effect, though slightly different from the alkaloid 3. Key words Heimia salicifolia, quinolizidine alkaloids, arterial pressure, hypertension Heimia salicifolia (HBK) Link, (Lithraceae) is a shrub which grows wild from Mexico to Argentina. In Mexico this plant is commonly known as “sinicuiche”, and has been used in folk medicine of several countries for many medical purposes (1,2). The chemical analysis of H. salicifolia leaves showed the presence of quinolizidine alkaloids as: nesodine, lyfoline vertine and lythrine. Several investigations have proposed that these alkaloids possess cardiovascular pharmacological effects producing hypotension in dogs, cats and rats (3, 4). In our laboratory we have found that the aqueous extract from H. salicifolia leaves decreased the systolic blood pressure in normotensive rats, therefore, the present study was designed to investigate the hypotensive and antihypertensive activity of the isolated alkaloids from H. -
6746695.Pdf (2.276Mb)
US006746695B1 a2, United States Patent (10) Patent No.: US 6,746,695 B1 Martin et al. (45) Date of Patent: Jun. 8, 2004 (54) PHARMACEUTICAL PREPARATIONS OF Abad, MJ et al., Anti-inflammatory activity of some medici- BIOACTIVE SUBSTANCES EXTRACTED nal plant extracts from Venezuela. J. Ethnopharmacol1996 FROM NATURAL SOURCES Dec;55(1):63-8. Alarcon—Aguilara, FJ, et al., Study of the anti-hyperglyce- (75) Inventors: Michael Z. Martin, Laupahoehoe, HI mic effect of plants used as antidiabetics. J. Ethnopharmacol (US); Mehdi Ashraf-Khorassani, 61 2:101-110 (1998). Blacksburg, VA (US); Larry Taylor, Blacksburg, VA (US) Almeida CE et al., Analysis of anti—diarrheic effect of plants used in popular medicine. Rev Saude Publica 1995 (73) Assignees: Armadillo Pharmaceuticals, Inc., Dec;29(6):428-33. Armocas, CA (US); Virginia Tech. Alves KB, et al., Inhibition of aminopeptidase activity by Intellectual Properties, Inc., aromatic and other cyclic compounds. Braz J Med Biol Res. Blackburg, VA (US) 1992;25(11):1103-6. Anesini C, et al., Screening of plants used in Argentine folk (*) Notice: Subject to any disclaimer, the term of this medicine for anti-microbial activity. J Ethnopharmacol. patent is extended or adjusted under 35 1993 Jun;39(2):119-28. US.C. 154(b) by 0 days. Arletti, R, et al., Stimulating property of Turnera diffusa and (21) Appl. No.: 09/578,849 Pfaffia paniculata extracts on the sexual behavior of male rats, Psychopharmacology (Berl). 1999 Mar;143(1):15-9. (22) Filed: May 26, 2000 Auterhoff, H et al., Constituents of the drug Damiana. Arch Pharm (Weinheim) 301:537-544(1968). -
Biosynthesis of Lythraceae Alkaloids Biosynthesis of Lythraceae Alkaloids
BIOSYNTHESIS OF LYTHRACEAE ALKALOIDS BIOSYNTHESIS OF LYTHRACEAE ALKALOIDS By SWE HOO KOO, M. Sc. A Thesis Submitted to the Faculty of Graduate Studies in Partial Fulfilment of the Requirements for the Degree Doctor of Philosophy McMaster University July, 1970 DOCTOR OF PHILOSOPHY (1970) McMASTER UNIVERSITY (Chemistry) Hamilton, Ontario TITLE: BiosynthesiR of Lythraceae Alkaloids J\U'l'HOR: Swe Hoo Koo, B. Sc. (Nanyang University) M. Sc. (University of Minnesota) SUPERVISOR: Professor Ian D. Spenser NUMBER OF PAGES: viii , 93 SCOPE AND CONTENTS: The biosynthesis of the alkaloids of Decodon verticillatus, (L.)Ell, a member of the Lythraceae family, was studied by tracer methods. These alkaloids contain a phenylquinolizidine system, whose biosynthetic origin has not previously been investigated. 1 Labelled samples of lysine, ll -piperideine and phenylalanine yielded radioact.ive decodine and decinine, the two major alkaloids of £. verticUlatus. 1 Systemati.c degradations of these labelled alkaloids show that lysine, t.. piperideine and phenylalanine serve as speci. fie precursors. Whereas lysine and A1-piperideine entered the quinolizidine ring, the biphenyl ring system of these alkaloids was derived from two units of phenylalanine. In a further experiment, labelled pelletierine was administered to the plants. But this experiment yielded an inconclusive result. (ii) ACKNOWLEDGMENTS The author wishes to express his sincere appreciation and thanks to Dr. I. D. Spenser for his guidance, encouragement and friendship throughout the course of this work, and to Dr. D. B. Ma.cLean for his interest in this work and useful discussion. He owes a debt of gratitude to Dr. R. N. Gupta for his invaluable help and collaboration. -
And Carrageenan-Induced Inflammation
University of the Pacific Scholarly Commons University of the Pacific Theses and Dissertations Graduate School 1981 Protective effects of certain lythraceae alkaloids and homologs in croton oil- and carrageenan-induced inflammation John Alan Byrne University of the Pacific Follow this and additional works at: https://scholarlycommons.pacific.edu/uop_etds Part of the Life Sciences Commons, Medicine and Health Sciences Commons, and the Physical Sciences and Mathematics Commons Recommended Citation Byrne, John Alan. (1981). Protective effects of certain lythraceae alkaloids and homologs in croton oil- and carrageenan-induced inflammation. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/2050 This Thesis is brought to you for free and open access by the Graduate School at Scholarly Commons. It has been accepted for inclusion in University of the Pacific Theses and Dissertations by an authorized administrator of Scholarly Commons. For more information, please contact [email protected]. PROTECTIVE EFFECTS OF CERTAIN LYTHRACEAE ALKALOIDS AND HOMOLOGS IN CROTON OIL AND CARRAGEENAN-INDUCED INFLAMMATION 'A Thesis Presented to the Faculty of the Graduate School University of the Pacific In Partial Fulfillment of the Requirements for the Degree Master of Science by John Alan Byrne November 1981 This thesis, written and submitted by John Alan Byrne is approved for recommendation to the Graduate Council, University of the Pacific. Department Chairman or Dean: , Chairman ~~/~?F w, November 24, 1981 ------------------ ------------------------------- ACKNOWLEDGMENTS The author wishes to express his sincere appreciation to: Dr. Marvin H. Malone for his guidance, enthusiasm and ------------- --pat-ie-n·ce -tfifou-gnout--th_e ___ c_OUI-_8_6_ -Of- thi_s __ stUdy. I deef>ly cherish the training, wisdom and friendship he has given to me during the past ten years of our association. -
Evaluation of Antihypertensive and Vasorelaxant Effects of Heimia Salicifolia (Family: Lythraceae)
Vol. 12(3), pp. 41-51, 22 January, 2018 DOI: 10.5897/AJPP2017.4860 Article Number: 7B7C12355849 African Journal of Pharmacy and ISSN 1996-0816 Copyright © 2018 Pharmacology Author(s) retain the copyright of this article http://www.academicjournals.org/AJPP Full Length Research Paper Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae) Elizabeth A. Guzmán-Hernández1, David Segura-Cobos1, Dante Amato1, José Guillermo Ávila- Acevedo2 and Beatriz Vázquez-Cruz1* 1Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación (UIICSE), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México. 2Laboratorio de Fitoquímica, Unidad de Biología, Tecnología y Prototipos (UBIPRO), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México. Received 18 October, 2017; Accepted 10 January, 2018 There are reports of the presence of vasodilatory alkaloids in Heimia salicifolia extracts. The action mechanisms of the potential antihypertensive effect of such alkaloids have not however, been elucidated. The objective of the present study was to corroborate the antihypertensive and vasorelaxant activities of the isolated alkaloids from H. salicifolia, and to characterize their vasorelaxant actions. A chloroform extract (HSCE) was obtained from H. salicifolia. The alkaloids were separated by thin layer chromatography, extracted from silica gel, and evaluated using spectroscopy. The alkaloid with the most potent vasorelaxant activity was identified as lythrine. The antihypertensive effect of the HSCE was corroborated on normotensive rats and on animals with Nω-nitro-L-arginine-methyl ester (L-NAME) induced hypertension. The action mechanisms of the HSCE and lythrine were studied on isolated and perfused rat mesenteric vascular bed (MVB) preparations. -
CPY Document
IA M)(XRAHS ON TH EVATION OF TH CACINIC RISK OF CHCA 'I MA: Sorn Cabartes, Thiocarbates and Carbazides Volur 12 This publication represents the views of an IA Working Group on the Evaluation of the Carcinogenc Risk of Chemcals to .M which net in Lyon, 9- 15 June 1976 lAC WORKING GROU ON TH EVATION OF TH CAINOENIC RISK OF CHCA TO MA: SC CATE, THICCTES AN CAIDES Lyon, 9-15 June 1976 Mernbers1 Dr R.R. Bates, Associate Corssioner for Science, US Foo and Drug Adnistration, 200 C Street SW, Washington IX 20204, USA (Chairman) Professor E. Boyland, TUC Institute of Occupational Health, London School of Hygiene and Tropical l1icine, Keppel Street, London ~LIE 7ll, UK Dr G.J. van Esch, Head, Laratory for Toxicolog, Rijks Instituut voor de Volksgezondheid, Antonie van Leuwenhoelaan 9, Bilthoven, The Netherlands ( Vice-Chairman) Dr D.E. Hathway, Senior Research Scientist, Cetral ToxicolCX.l Laratory, Imial Chercal Industries Lirted, Alderley Park, Cheshire SKIO 4TJ, OK Dr W. Li j insky, Frederick Cacer Research Centre, PO Box B, F'rederick, Maland 21701, USA Professor U. !-hr, Director, Abteilung ftr Exrimtelle Pathologie, Medizinische Hochschule Hanover, Kal Wiechert Allee 9, 3 Haover 61, FRG Dr S. D. Muhy, Assoiate Professor of Toxicolog, School of Pulic Heal th, Depart of Physiolog, Haard University, 665 Huntington Avenue, Boston, Massachusetts 02115, USA Dr V. B. Okulov, N. Petrov Research Insti tute of Oncolog, 68 Leningradskaya Street, Pesochny-2, Leningrad 188646, USSR Dr C. Ral, Stockholm Universitet, Wallenbrglalratoriet, Lilla Frescati, S- 104 05 Stockholm 50, Swden Dr B. Teichr, Akadere der Wissenschaften der DDR, Zentralinstitut ftr Krebsforschung, Lindenbrger Weg 80, 1115 Ber lin- Buch , GOR Dr B. -
ICD-10-CM TABLE of DRUGS and CHEMICALS 2020
ICD-10-CM TABLE of DRUGS and CHEMICALS Substance Poisoning Poisoning Poisoning Poisoning Adverse effect Underdosing Accidental Intentional Assault Undetermined (unintentional) self-harm 1-propanol T51.3X1 T51.3X2 T51.3X3 T51.3X4 -- -- 2-propanol T51.2X1 T51.2X2 T51.2X3 T51.2X4 -- -- 2,4-D (dichlorophen-oxyacetic acid) T60.3X1 T60.3X2 T60.3X3 T60.3X4 -- -- 2,4-toluene diisocyanate T65.0X1 T65.0X2 T65.0X3 T65.0X4 -- -- 2,4,5-T (trichloro-phenoxyacetic acid) T60.1X1 T60.1X2 T60.1X3 T60.1X4 -- -- 3,4-methylenedioxymethamphetamine T43.641 T43.642 T43.643 T43.644 -- -- 14-hydroxydihydro-morphinone T40.2X1 T40.2X2 T40.2X3 T40.2X4 T40.2X5 T40.2X6 Substance Poisoning Poisoning Poisoning Poisoning Adverse effect Underdosing Accidental Intentional Assault Undetermined (unintentional) self-harm ABOB T37.5X1 T37.5X2 T37.5X3 T37.5X4 T37.5X5 T37.5X6 Abrine T62.2X1 T62.2X2 T62.2X3 T62.2X4 -- -- Abrus (seed) T62.2X1 T62.2X2 T62.2X3 T62.2X4 -- -- Absinthe T51.0X1 T51.0X2 T51.0X3 T51.0X4 -- -- - beverage T51.0X1 T51.0X2 T51.0X3 T51.0X4 -- -- Acaricide T60.8X1 T60.8X2 T60.8X3 T60.8X4 -- -- Acebutolol T44.7X1 T44.7X2 T44.7X3 T44.7X4 T44.7X5 T44.7X6 Acecarbromal T42.6X1 T42.6X2 T42.6X3 T42.6X4 T42.6X5 T42.6X6 Aceclidine T44.1X1 T44.1X2 T44.1X3 T44.1X4 T44.1X5 T44.1X6 Acedapsone T37.0X1 T37.0X2 T37.0X3 T37.0X4 T37.0X5 T37.0X6 Acefylline piperazine T48.6X1 T48.6X2 T48.6X3 T48.6X4 T48.6X5 T48.6X6 Acemorphan T40.2X1 T40.2X2 T40.2X3 T40.2X4 T40.2X5 T40.2X6 Acenocoumarin T45.511 T45.512 T45.513 T45.514 T45.515 T45.516 Acenocoumarol T45.511 T45.512 T45.513 T45.514 -
Alkaloids.Tarek Kakhia.Pdf
ADANA UNIVERSTY – INDUSTRY JOINT RESEARCH CENTER ALKALOIDS & ALKALOIDS PLANTS By TAREK ISMAIL KAKHIA 1 2 INDEX Itam Page Itam No 1 - Alkaloids : 1 Alkaloids 2 Atropine 3 Caffeine 4 Cocaine 5 Codaine 6 Heroine 7 Lidocaine 8 Morphin 9 Nicotine 10 Papaverine 11 Solanine 2 - Alkaliod Plants 1 Belladonna 2 Cannabis 3 Cannabis ( Drug ) 4 Cannabis ( Altivation ) 5 Coca 6 Coffee 7 Datura Stramonium 8 Datura 9 Hashish 10 Khat 11 Opium 12 Opium Poppy 3 13 Tea 14 Tobacco 15 Yerba Mate 3 - Alkaliod Plants Time Line 1 Time Line of Cannabis 1 2 Time Line of Cannabis 2 3 Time Line of Coca 4 Time Line of Coffee 5 Time Line of Datura 6 Time Line of Hashish 7 Time Line of Khat 8 Time Line of Poppy & Opium 9 Time Line of Tea 10 Time Line of Tobacco 11 Time Line of Yerba Mat 12 Time Line of 4 - Extension and Supplements 1 Night Shade Alkaloid Toxins Atropine , Scopolamine and Solanine 2 Hyoscyamus Niger 3 Nerium Oleander 4 PART – 1 ALKALOIDS 5 6 Alkaloid Chemical structure of ephedrine, a phenethylamine alkaloid Contents : 1 Introduction 2 Alkaloid Classifications 3 Physicochemical Properties 4 Category : Alkaloids 1 – Introduction : Alkaloids are naturally occurring chemical compounds containing basic nitrogen atoms . The name derives from the word alkaline and was used to describe any nitrogen - containing base. Alkaloids are produced by a large variety of organisms, including bacteria, fungi, plants, and animals and are part of the group of natural products (also called secondary metabolites ) . Many alkaloids can be purified from crude extracts by acid - base extraction. -
ICD-10-CM TABLE of DRUGS and CHEMICALS
ICD-10-CM TABLE of DRUGS and CHEMICALS Substance Poisoning, Poisoning, Poisoning, Poisoning, Adverse effect Underdosing Accidental Intentional Assault Undetermined (unintentional) self-harm 1-propanol T51.3X1 T51.3X2 T51.3X3 T51.3X4 -- -- 2-propanol T51.2X1 T51.2X2 T51.2X3 T51.2X4 -- -- 2,4-D (dichlorophen-oxyacetic acid) T60.3X1 T60.3X2 T60.3X3 T60.3X4 -- -- 2,4-toluene diisocyanate T65.0X1 T65.0X2 T65.0X3 T65.0X4 -- -- 2,4,5-T (trichloro-phenoxyacetic acid) T60.1X1 T60.1X2 T60.1X3 T60.1X4 -- -- 14-hydroxydihydro-morphinone T40.2X1 T40.2X2 T40.2X3 T40.2X4 T40.2X5 T40.2X6 Substance Poisoning, Poisoning, Poisoning, Poisoning, Adverse effect Underdosing Accidental Intentional Assault Undetermined (unintentional) self-harm ABOB T37.5X1 T37.5X2 T37.5X3 T37.5X4 T37.5X5 T37.5X6 Abrine T62.2X1 T62.2X2 T62.2X3 T62.2X4 -- -- Abrus (seed) T62.2X1 T62.2X2 T62.2X3 T62.2X4 -- -- Absinthe T51.0X1 T51.0X2 T51.0X3 T51.0X4 -- -- - beverage T51.0X1 T51.0X2 T51.0X3 T51.0X4 -- -- Acaricide T60.8X1 T60.8X2 T60.8X3 T60.8X4 -- -- Acebutolol T44.7X1 T44.7X2 T44.7X3 T44.7X4 T44.7X5 T44.7X6 Acecarbromal T42.6X1 T42.6X2 T42.6X3 T42.6X4 T42.6X5 T42.6X6 Aceclidine T44.1X1 T44.1X2 T44.1X3 T44.1X4 T44.1X5 T44.1X6 Acedapsone T37.0X1 T37.0X2 T37.0X3 T37.0X4 T37.0X5 T37.0X6 Acefylline piperazine T48.6X1 T48.6X2 T48.6X3 T48.6X4 T48.6X5 T48.6X6 Acemorphan T40.2X1 T40.2X2 T40.2X3 T40.2X4 T40.2X5 T40.2X6 Acenocoumarin T45.511 T45.512 T45.513 T45.514 T45.515 T45.516 Acenocoumarol T45.511 T45.512 T45.513 T45.514 T45.515 T45.516 Acepifylline T48.6X1 T48.6X2 T48.6X3 T48.6X4 T48.6X5 -
Table of Drugs and Chemicals (FY12)
ICD-9-CM Table of Drugs and Chemicals (FY12) Table of Drugs and Chemicals INDEX TO POISONING AND EXTERNAL CAUSES OF ADVERSE EFFECTS OF DRUGS AND OTHER CHEMICAL SUBSTANCES This table contains a classification of drugs and other chemical substances to identify poisoning states and external causes of adverse effects. Each of the listed substances in the table is assigned a code according to the poisoning classification (960-989). These codes are used when there is a statement of poisoning, overdose, wrong substance given or taken, or intoxication. The table also contains a listing of external causes of adverse effects. An adverse effect is a pathologic manifestation due to ingestion or exposure to drugs or other chemical substances (e.g., dermatitis, hypersensitivity reaction, aspirin gastritis). The adverse effect is to be identified by the appropriate code found in Section 1, Index to Diseases and Injuries. An external cause code can then be used to identify the circumstances involved. The table headings pertaining to external causes are defined below: Accidental poisoning (E850-E869)accidental overdose of drug, wrong substance given or taken, drug taken inadvertently, accidents in the usage of drugs and biologicals in medical and surgical procedures, and to show external causes of poisonings classifiable to 980-989. Therapeutic use (E930-E949)a correct substance properly administered in therapeutic or prophylactic dosage as the external cause of adverse effects. Suicide attempt (E950-E952)instances in which self-inflicted injuries or poisonings are involved. Assault (E961-E962)injury or poisoning inflicted by another person with the intent to injure or kill. -
ICD-10-CM Table of Drugs 2019
ICD-10-CM TABLE of DRUGS and CHEMICALS Substance Poisoning Poisoning Poisoning Poisoning Adverse effect Underdosing Accidental Intentional Assault Undetermined (unintentional) self-harm 1-propanol T51.3X1 T51.3X2 T51.3X3 T51.3X4 -- -- 2-propanol T51.2X1 T51.2X2 T51.2X3 T51.2X4 -- -- 2,4-D (dichlorophen-oxyacetic acid) T60.3X1 T60.3X2 T60.3X3 T60.3X4 -- -- 2,4-toluene diisocyanate T65.0X1 T65.0X2 T65.0X3 T65.0X4 -- -- 2,4,5-T (trichloro-phenoxyacetic acid) T60.1X1 T60.1X2 T60.1X3 T60.1X4 -- -- 3,4-methylenedioxymethamphetamine T43.641 T43.642 T43.643 T43.644 -- -- 14-hydroxydihydro-morphinone T40.2X1 T40.2X2 T40.2X3 T40.2X4 T40.2X5 T40.2X6 Substance Poisoning Poisoning Poisoning Poisoning Adverse effect Underdosing Accidental Intentional Assault Undetermined (unintentional) self-harm ABOB T37.5X1 T37.5X2 T37.5X3 T37.5X4 T37.5X5 T37.5X6 Abrine T62.2X1 T62.2X2 T62.2X3 T62.2X4 -- -- Abrus (seed) T62.2X1 T62.2X2 T62.2X3 T62.2X4 -- -- Absinthe T51.0X1 T51.0X2 T51.0X3 T51.0X4 -- -- - beverage T51.0X1 T51.0X2 T51.0X3 T51.0X4 -- -- Acaricide T60.8X1 T60.8X2 T60.8X3 T60.8X4 -- -- Acebutolol T44.7X1 T44.7X2 T44.7X3 T44.7X4 T44.7X5 T44.7X6 Acecarbromal T42.6X1 T42.6X2 T42.6X3 T42.6X4 T42.6X5 T42.6X6 Aceclidine T44.1X1 T44.1X2 T44.1X3 T44.1X4 T44.1X5 T44.1X6 Acedapsone T37.0X1 T37.0X2 T37.0X3 T37.0X4 T37.0X5 T37.0X6 Acefylline piperazine T48.6X1 T48.6X2 T48.6X3 T48.6X4 T48.6X5 T48.6X6 Acemorphan T40.2X1 T40.2X2 T40.2X3 T40.2X4 T40.2X5 T40.2X6 Acenocoumarin T45.511 T45.512 T45.513 T45.514 T45.515 T45.516 Acenocoumarol T45.511 T45.512 T45.513 T45.514