Figure S2.1. Comparison between binning of predicted genes and 16s rRNA genes for taxonomic assignment.
MMK
MMR
MNK
MNR
100% Bac265k, (KP795920) 57% Bacillus licheniformis, (GU323366) 100% Bac266k, (KP795921) 100% Bacillus cereus, (AB523742) 50% Bac49R, (KP795896) 50% Bac5R, (KP795897) 50% Bac48R, (KP795895) 53% Bac84R, (KP795909) 93% Bac96R, (KP795914) 100% Bacillus licheniformis, (HQ123486) 99% Bacillus licheniformis, (JN645851) 100% Bac47R, (KP795894) 100% Bacillus aerius, (KC443077) 50% Bacillus sp. BJC1.1, (FJ769134) 92% Bac123R, (KP795816) 100% Bacillus licheniformis, (JF802183) 82% Bac167R, (KP795830) 100% Bacillus sonorensis, (JN999895) 95% Bac184K, (KP795834) 92% Bacillus sp. MK−2, (JQ963331) 100% Bacillus sp. WMMB 723, (KC856900) 100% Bac220K, (KP795846) 50% Bacillus licheniformis, (KF770990) 73% Bac4R, (KP795891) 100% Bacillus licheniformis, (GU945224) 51% Bac166R, (KP795829) 92% Bac168R, (KP795831) 100% Bacillus sp. 2BSG−10NA−9, (AB533766) 100% Bacillus sonorensis, (HQ696443) 100% Bac116R, (KP795809) 100% Bac118R, (KP795811) 100% Bac119R, (KP795812) 53% Bac127R, (KP795817) 100% Bac248K, (KP795855) 100% Bac139R, (KP795822) 100% Bac142R, (KP795823) 100% Bac245K, (KP795852) 100% Bac247K, (KP795854) 100% Bac250K, (KP795857) 100% Bac253K, (KP795860) 100% Bac71R, (KP795902) 100% Bac74R, (KP795903) 100% Bac79R, (KP795907) Bacillales_Bacillaceae_Bacillus_2 80% Bac80R, (KP795908) 100% Bac90R, (KP795911) 100% Bac284K, (KP795864) 56% Bacillus licheniformis, (GQ903411) 64% Bac277k, (KP795924) 92% Bac283K, (KP795863) 100% Bac183K, (KP795833) 82% Bac214K, (KP795842) 100% Bac218K, (KP795843) 100% Bacillus pumilus, (FJ390472) 100% Bacillus safensis, (KF641818) 100% Bac208, (KP980798) 100% Bac190K, (KP795836) 100% Bac207K, (KP795837) 100% Bac209K, (KP795838) 56% Bac298K, (KP795868) 100% Bacillus atrophaeus, (KC789780) 100% Bac115R, (KP795808) 100% Bacillus sp. hb63, (KF863858) 100% Bac111R, (KP795807) 72% Bac256k, (KP795918) 100% Bacillus subtilis, (HQ111353) 100% Bacillus amyloliquefaciens, (JQ308574) 100% Bacillus tequilensis, (HQ844467) 100% Bacillus sp. CZB20, (KF482850) 100% Bacillus methylotrophicus, (JN700129) 100% Bac372R, (KP795879) 100% Bac50R, (KP795898) 85% Bac52R, (KP795899) 100% Bac57R, (KP795901) 100% Bac105R, (KP795803) 100% Bac106R, (KP795804) 50% Bac95, (KP795913) 50% Bac97R, (KP795915) 53% Bacillus vallismortis DV1−F−3, (AFSH01000065) 55% Bac254k, (KP795917) 100% Bacillus subtilis, (EU998984) 100% Bacillus subtilis, (HQ443223) 100% Bacillus licheniformis, (AB819830) 53% Bac189K, (KP795835) 67% Bac278K, (KP795861) 100% Bac345R, (KP795876) 95% Bac21R, (KP795839) 82% Bac279K, (KP795862) 100% Bac76R, (KP795905) 100% Virgibacillus chiguensis, (EF101168) 100% Virgibacillus dokdonensis, (AY822043) 100% Virgibacillus pantothenticus, (JN791392) 100% Bac24R, (KP795847) 100% Bac78R, (KP795906) 100% Bac327R, (KP795872) 100% Bac330R, (KP795873) Virgibacillus_2 54% Bac332R, (KP795874) 91% Bac75R, (KP795904) 100% Bac22R, (KP795845) 80% Bac318R, (KP795870) 100% Bac210K, (KP795840) 100% Virgibacillus marismortui, (DQ010162) 100% Bac299K, (KP795869) 100% Bac333R, (KP795875) 100% Bac121R, (KP795814) Bacillales_Bacillaceae_4 55% Bac376R, (KP795881) 100% Virgibacillus kekensis, (AY121439) 100% Bac289K, (KP795865) 63% Virgibacillus sp. TKNR13−3, (HM364289) Firmicutes_Bacilli 100% Bac296K, (KP795867) Virgibacillus_7 100% Virgibacillus sp. SK32, (DQ910837) 100% Bac324R, (KP795871) 51% Virgibacillus halodenitrificans, (EU834234) 100% Ornithinibacillus contaminans, (KF425516) 100% Oceanobacillus chironomi, (DQ298074) Oceanobacillus 80% Oceanobacillus indicireducens, (AB623011) Bacillales_Bacillaceae_3 100% Bacillus thermocloaceae, (Z26939) 54% Bac249K, (KP795856) 50% Bacillus pumilus, (GQ903428) Oceanobacillus_2 100% Ornithinibacillus sp. ZM1, (FJ373040) 100% Bac241K, (KP795848) Salirhabdus 83% Salirhabdus euzebyi, (AM292417) 100% Saliterribacillus persicus, (HQ433437) 100% Virgibacillus albus, (JQ680032) 63% Bac102R, (KP795802) 97% Bacillus korlensis, (HM563051) 100% Bac275k, (KP795923) 100% Bac358K, (KP795878) 100% Bacillus sp. EB301, (HM573379) 66% Bac55R, (KP795900) 80% Bacillus sp. KLBMP 2447, (JN119354) 100% Bac243K, (KP795850) 100% Bacillus sp. HHS1, (AB539835) 100% Bac144R, (KP795824) 99% Bac147R, (KP795825) 100% Bacillus sp. NCCP−168, (AB618147) 65% Bac132R, (KP795818) 100% Bac213K, (KP795841) 100% Bacillus sp. FA136, (JQ083326) 58% Bac133R, (KP795819) 100% Bac219K, (KP795844) 97% Bac122R, (KP795815) 100% Bac262k, (KP795919) 97% Bacillus oceanisediminis 2691, (ALEG01000035) 59% Bac117R, (KP795810) 100% Bacillus firmus, (JX428993) 94% Bac164R, (KP795827) 99% Paenibacillus polymyxa, (HQ317157) Paenibacillus_10 100% Bac163R, (KP795826) 100% Paenibacillus sp. SSKSD13, (KF751678) 100% Bac390R, (KP795888) 100% Paenibacillus dendritiformis, (KF850540) Paenibacillus_13 100% Paenibacillus thiaminolyticus, (AB680934) 100% Microaerobacter geothermalis, (FN552009) 69% Bac38R, (KP795882) 58% Bac39R, (KP795887) 57% Bacillus foraminis, (KF724906) 100% Bac45R, (KP795893) 86% Bac44R, (KP795892) 100% Bac134R, (KP795820) 100% Bacillus niacini, (HM854263) 100% Bac109R, (KP795805) 100% Brevibacillus borstelensis, (D78456) 100% Bac110R, (KP795806) 100% Bac98R, (KP795916) Brevibacillus 100% Bac165R, (KP795828) 100% Bac171R, (KP795832) 100% Brevibacillus agri, (HQ166189) 100% Aneurinibacillus migulanus, (AB680889) 100% Bac270, (KP980744) Bacillales_Paenibacillaceae_Aneurinibacillus 100% Bac271, (KP980745) 100% Bacillus cereus, (HQ844479) 100% Bacillus thuringiensis, (KF367462) 100% Bacillus cereus, (JF496546) 100% Bacillus cereus, (KF484678) 100% Bacillus anthracis, (KF601916) 100% Bacillus thuringiensis, (JX997827) 68% Bac373R, (KP795880) 69% Bacillus cereus, (KC428746) Bacillales_Bacillaceae_Bacillus_1 100% Bac386R, (KP795885) 100% Bac355K, (KP795877) 100% Bac381R, (KP795883) 100% Bac385R, (KP795884) 100% Bac389R, (KP795886) 100% Bac393R, (KP795889) 83% Bac394R, (KP795890) 100% Bac255, (KP980736) Enterococcus 100% Enterococcus dispar ATCC 51266, (AHYR01000005) Enterococcaceae_2 83% Melissococcus plutonius ATCC 35311, (AP012200) 100% Bac135R, (KP795821) Lysinibacillus_2 100% Lysinibacillus odysseyi, (AF526913) 100% Bac246K, (KP795853) 100% Bacillus firmus, (JX144707) 100% Bacillus massiliosenegalensis JC6, (JF824800) 100% Bac251K, (KP795858) 54% Bac252K, (KP795859) 100% Bacillus sp. DV9−30, (GQ407175) 100% uncultured bacterium, (AB533940) 4−15 100% uncultured bacterium, (AB533882) 100% uncultured bacterium, (AB533961) 97% uncultured bacterium, (AB533926) 100% uncultured bacterium, (AB533891) 100% Bac268k, (KP795922) 100% Bacillus circulans, (JN645982) 86% Bac242K, (KP795849) 100% Bac295K, (KP795866) 100% Bac94R, (KP795912) 83% Bac89R, (KP795910) 83% Bac244K, (KP795851) 100% Bac387, (KR140154) 84% Exiguobacterium sp. BJ−56, (GQ280066) 70% Exiguobacterium profundum, (AY818050) 100% Exiguobacterium marinum, (AY594266) Exiguobacterium 100% Exiguobacterium aestuarii, (AY594264) 100% Exiguobacterium aquaticum, (JF775503) 100% Exiguobacterium mexicanum, (AM072764) 82% Exiguobacterium aurantiacum, (X70316) 100% 16 Actinobacteria 82%
97% 148 Proteobacteria
100% 100% 18 Bacteroidetes 100% 100% 17 Planctomycetacia_Planctomycetales_Planctomyce Thermogymnomonas acidicola, (AB269873)
0.10 83% 216 Firmicutes_Bacilli
82% 100% 16 Actinobacteria 82% 82% Bac258, (KP980738) 92% Vibrio parahaemolyticus, (JQ434012) 69% Vibrio alginolyticus, (KC210811) 77% Vibrio alginolyticus, (JN188402) 100% Bac37, (KP980772) 77% Bac34, (KP980764) 100% Vibrio sp. H−176, (KF021850) 60% Bac30, (KP980753) 100% Bac7, (KP980791) 100% Vibrio alginolyticus, (EF219054) 100% Vibrio alginolyticus, (JF784015) 60% Bac13, (KP980709) 100% Bac28, (KP980748) 92% Vibrio sp. HSML−FTL−9c, (KF148601) 100% Vibrio sp. DH147, (EF199917) 100% Vibrio parahaemolyticus, (HQ694830) 75% Bac202, (KP980730) 100% Vibrio sp. Y4tang, (EF187013) 50% Vibrio alginolyticus, (JN188404) Vibrio_4 100% Vibrio alginolyticus, (JN188412) 100% Bac16, (KP980710) 100% Bac17, (KP980711) 98% Bac27, (KP980743) 100% Vibrio sp. MA35, (GU951701) Vibrionales_Vibrionaceae 68% Vibrio sp. W−137−8, (KF746898) 100% Bac18, (KP980717) 100% Vibrio sp. JNU−H007−1, (KC174815) 100% Vibrio azureus, (KC210816) 100% Bac1, (KP980708) 100% Bac173, (KP980712) 100% Bac180, (KP980718) 100% Bac2, (KP980727) 100% Bac200, (KP980728) 100% Bac201, (KP980729) 100% Bac203, (KP980731) 100% Bac204, (KP980732) 100% Bac257, (KP980737) 100% Bac3, (KP980752) 100% Bac217, (KP980734) 100% Bac267, (KP980741) 100% Bac269, (KP980742) 100% Bac273, (KP980747) 100% Bac58, (KP980784) Salinivibrio 65% Bac60, (KP980786) 100% Bac83, (KP980795) 100% Salinivibrio costicola, (JX913853) 100% Salinivibrio proteolyticus, (JX501730) 51% Bac338, (KP980763) 100% Pseudoalteromonas sp. NJ5−9, (AY781154) 100% Pseudoalteromonas sp. 18III/A01/058, (AY576713) 100% Pseudoalteromonas sp. T5304, (AB183513) 100% Bac291, (KP980750) 100% Bac302, (KP980755) 54% Bac320, (KP980758) 100% Bac336, (KP980761) 95% Pseudoalteromonas espejiana, (KC534268) 70% Bac326, (KP980759) 70% Bac342, (KP980765) 100% Pseudoalteromonas sp. 1−Z18, (HM584478) 89% Bac292, (KP980751) 94% Pseudoalteromonas issachenkonii, (AF316144) 64% Bac319, (KP980756) 100% Bac337, (KP980762) 72% Pseudoalteromonas espejiana, (JX867735) 100% Bac186, (KP980721) Gammaproteobacteria_1 100% Pseudoalteromonas sp. NUM8, (JX435820) 100% Bac192, (KP980722) 94% Bac369, (KP980771) Pseudoalteromonas 96% Bac82, (KP980794) 100% Bac178, (KP980715) 59% Bac198, (KP980726) 100% Bac174, (KP980713) 94% Bac185, (KP980720) 100% Bac194, (KP980724) Proteobacteria 96% Pseudoalteromonas flavipulchra, (JQ782750) 100% Bac179, (KP980716) 100% Bac231, (KP980735) 100% Pseudoalteromonas sp. Gumar, (HQ449967) 100% Pseudoalteromonas maricaloris, (AF144036) 74% Bac351, (KP980767) 100% Bac59, (KP980785) 85% Bac77, (KP980793) 100% uncultured bacterium, (JX680696) 100% Pseudoalteromonas sp. HK41, (HQ343275) 100% Pseudoalteromonas ruthenica CP76, (AOPM01000107) 100% Pseudoalteromonas ruthenica, (AB617563) 100% Bac301, (KP980754) 100% Bac383, (KP980779) 60% Bac384, (KP980780) 100% Bac62, (KP980787) 100% Saccharospirillum sp. MH−I15, (JQ231213) Saccharospirillaceae_Saccharospirillum 100% Saccharospirillum salsuginis, (EF177670) 67% Saccharospirillum aestuarii, (GQ250189) 65% Bac54, (KP980782) 60% Bac56, (KP980783) 97% Bac261, (KP980740) 58% Bac35, (KP980766) 51% Bac53, (KP980781) 100% Bac33, (KP980760) 100% Microbulbifer variabilis, (FM180508) 100% Microbulbifer variabilis, (AB167354) 84% Microbulbifer donghaiensis, (EU365694) 84% Microbulbifer taiwanensis, (FR822983) 100% Microbulbifer marinus, (GQ262812) Microbulbifer 100% Bac177, (KP980714) 100% Bac197, (KP980725) 100% Microbulbifer celer, (EF486352) 100% Microbulbifer sp. ML17, (JN791345) 100% Bac29, (KP980749) 78% Microbulbifer sp. Th/B/38, (AY224196) 92% Microbulbifer yueqingensis, (GQ262813) 83% Bac32, (KP980757) 100% Bac85, (KP980796) 62% Microbulbifer sp. GB02−2C, (GQ118708) 71% Bac374, (KP980775) 83% Pseudomonas fluorescens, (JQ691695) Pseudomonas_1 100% Bac375, (KP980776) 59% Pseudomonas azotoformans, (JX134626) 99% Bac216, (KP980733) 100% Bac272, (KP980746) 100% Marinobacter mobilis, (HQ284162) 100% Bac370, (KP980773) Alteromonadales_Alteromonadaceae_Marinobacter 52% Bac87, (KP980797) 100% Marinobacter sp. GX18A2−1, (KF201605) 92% Marinobacter hydrocarbonoclasticus, (KF824854) 100% Bac63, (KP980788) 75% Bac69, (KP980790) 59% Bac70, (KP980792) Psychrobacter 100% Bac66, (KP980789) 92% Psychrobacter sp. B−5151, (DQ399761) 52% Bac366, (KP980770) 100% Bac380, (KP980778) Stenotrophomonas 97% Stenotrophomonas maltophilia, (HM625746) 100% Bac260, (KP980739) 100% Ruegeria mobilis, (KF052993) 100% Ruegeria mobilis, (HQ338148) 82% Bac353, (KP980768) 100% Bac371, (KP980774) Ruegeria_1 54% Bac361, (KP980769) 100% Bac378, (KP980777) 64% Roseobacter sp. TM1040, (AY332662) Alphaproteobacteria 85% Ruegeria sp. TM1040, (CP000376) 100% Bac193, (KP980723) 100% Stappia sp. EM−1, (HM584720) Labrenzia_1 100% Labrenzia alba, (AJ878875) 100% Bac120R, (KP795813) 100% Oceanicaulis sp. DG1255, (DQ486495) Oceanicaulis 100% Oceanicaulis stylophorae, (HM035090) 100% 18 Bacteroidetes 100% 100% 17 Planctomycetacia_Planctomycetales_Planctomyce Thermogymnomonas acidicola, (AB269873)
0.10 83% 216 Firmicutes_Bacilli
82% 100% Bac181, (KP980719) 100% Brevibacterium sp. BS05, (JF806518) Brevibacteriaceae_Brevibacterium 50% Brevibacterium sp., (D88212) 100% Bac46, (KP980808) Isoptericola_1 100% Isoptericola chiayiensis, (FJ469988) Micrococcales_1 100% Beutenbergia cavernae DSM 12333, (CP001618) 54% Bac334, (KP980804) Micrococcus_1 100% Micrococcus luteus, (AJ717367) Actinobacteria 100% Micrococcus yunnanensis, (JQ659453) 100% Bac41, (KP980806) 74% Bac42, (KP980807) 66% Gordonia hankookensis, (FJ572038) 100% Gordonia terrae, (AF397061) Gordonia 100% Bac335, (KP980805) 100% Gordonia aichiensis, (X81925) 82% Gordonia otitidis, (AB122026)
97% 148 Proteobacteria
100% 100% Pontibacter sp. H9X, (KF146891) 100% Pontibacter xinjiangensis, (FJ004994) 100% uncultured Pontibacter sp., (KF851214) 100% uncultured bacterium, (DQ298346) 100% uncultured bacterium, (JQ428773) Pontibacter 75% uncultured Pontibacter sp., (KC166831) 100% Bac128, (KP980799) 100% Bac129, (KP980800) 100% Bac130, (KP980801) Bacteroidetes 76% Bac140, (KP980802) 52% uncultured bacterium, (EU722656) 71% Flavobacteriaceae bacterium UDC353, (GQ246641) Salinimicrobium 100% Salinimicrobium xinjiangense, (EF520007) 100% Salinimicrobium sp. JC207, (HG008896) 53% Salinimicrobium terrae, (EU135614) 100% Bac274, (KP980803) 100% Fulvivirga kasyanovii, (DQ836305) Fulvivirga 100% Fulvivirga imtechensis, (FR687203) 56% Pirellula sp., (X86387) 100% Pirellula sp. 16, (AF453519) 57% planctomycete DWL102, (JF443742) 100% Blastopirellula cremea, (JF748733) 54% Bac176, (KP795799) Blastopirellula 100% planctomycete str. 116, (AJ231181) 100% Bac175, (KP795800) 70% Bac67, (KP795801) 50% Bac93, (KP795798) Planctomycetacia_Planctomycetales_Planctomyce 100% uncultured planctomycete, (EF061980) 100% Planctomyces brasiliensis, (AJ231190) 100% Planctomyces brasiliensis DSM 5305, (CP002546) 100% Planctomyces sp., (X85249) 96% Bac92, (KP795797) Planctomyces_1 100% planctomycete MS1330, (JF443791) 100% planctomycete MS3039, (JF443792) Bac131, (KP795796) Thermogymnomonas acidicola, (AB269873)
0.10 Table S2.2. Functions related to.
COMPARISON GROUP Log Odds Ratio | Relative risk | p-value
Aromatic Compound Degradation MMK vs MMR 0.333 | 1.3696 | p < 0.05 MMK vs MNR 0.138 | 1.1387 | p < 0.05 MMR vs MNK -0.274 | 0.7715 | p < 0.05 MNK vs MNR 0.080 | 1.0777 | p < 0.05 MMK vs MNK 0.059 | 1.0566 | p < 0.05 MMR vs MNR -0.195 | 0.8314 | p < 0.05
Xenobiotics biodegradation MMK vs MMR 0.448 | 1.5541 | p < 0.05 MMK vs MNR 0.193 | 1.2086 | p < 0.05 MMR vs MNK -0.415 | 0.6649 | p < 0.05 MNK vs MNR 0.16 | 1.1697 | p < 0.05 MMK vs MNK 0.033 | 1.0333 | p=0.0715 MMR vs MNR -0.255 | 0.7777 | p < 0.05
Styrene degradation MMK vs MMR 0.523 | 1.6864 | p < 0.05
anaerobic aromatic compound degradation (Thauera aromatica) MMK vs MMR 0.344 | 1.3916 | p < 0.05 MMK vs MNR 0.14 | 1.1432 | p < 0.05 MMR vs MNK -0.278 | 0.7648 | p < 0.05 MNK vs MNR 0.074 | 1.0741 | p < 0.05
Benzoate degradation MMK vs MMR 0.886 | 2.4174 | p < 0.05 MMK vs MNR 0.442 | 1.5522 | p < 0.05 MMR vs MNK -0.968 | 0.3816 | p < 0.05 MNK vs MNR 0.523 | 1.6828 | p < 0.05
Toluene degradation MMK vs MMR 0.557 | 1.743 | p < 0.05 MMK vs MNR 0.234 | 1.2634 | p < 0.05 MMR vs MNK -0.465 | 0.6287 | p < 0.05 MNK vs MNR 0.142 | 1.1528 | p < 0.05
Ethylbenzene degradation MMK vs MMR 0.451 | 1.5683 | p < 0.05 MMK vs MNR 0.244 | 1.2755 | p < 0.05 MMR vs MNK -0.377 | 0.6863 | p < 0.05 MNK vs MNR 0.170 | 1.185 | p < 0.05
Xylene degradation MMK vs MMR 0.434 | 1.5433 | p < 0.05 MMK vs MNR 0.544 | 1.7224 | p < 0.05 MMR vs MNK -0.455 | 0.6344 | p < 0.05 MNK vs MNR 0.565 | 1.7593 | p < 0.05 Table S2.3. Bioactive compounds.
Identity Class Protein Phylum Genus High Identities >=45% PKS Polyketide synthase Cyanobacteria Nostoc_unclassified High Identities >=45% PKS Polyketide synthase family protein Cyanobacteria Nostoc_unclassified High Identities >=45% PKS Polyketide synthase Thaumarchaeota Nitrosopumilus_unclassified High Identities >=45% NRPS Dimodular nonribosomal peptide synthase DhbF Thaumarchaeota environmental samples_unclassified High Identities >=45% antibiotic resistance ABC transporter superfamily Chloroflexi Chloroflexaceae High Identities >=45% antibiotic resistance aminoglycoside-4'-adenyltransferase Bacteroidetes Rhodothermus_unclassified High Identities >=45% antibiotic resistance BaeR family transcriptional regulator Proteobacteria Syntrophobacter High Identities >=45% antibiotic resistance chloramphenicol acetyltransferase Thaumarchaeota Nitrosopumilus_unclassified High Identities >=45% antibiotic resistance Dihydrofolate reductase family environmental samples environmental samples_unclassified High Identities >=45% antibiotic resistance DNA gyrase subunit A Proteobacteria Geobacter High Identities >=45% antibiotic resistance macrolide export ATP-binding/permease protein MacB Proteobacteria Anaeromyxobacteraceae High Identities >=45% antibiotic resistance putative cation efflux system protein Bacteroidetes Algoriphagus High Identities >=45% antibiotic resistance Response regulator protein VraR candidate division NC10 Candidatus Methylomirabilis_unclassified High Identities >=45% antibiotic resistance Ribosomal protein L11P family Synergistetes Anaerobaculum High Identities >=45% antibiotic resistance Ribosomal protein L16P family Caldithrix Caldithrix_unclassified High Identities >=45% antibiotic resistance Ribosomal protein L22P family Proteobacteria Deltaproteobacteria_unclassified High Identities >=45% antibiotic resistance Ribosomal protein L4P family Acidobacteria Thermoanaerobaculum_unclassified High Identities >=45% antibiotic resistance Ribosomal protein S12P family Chloroflexi Anaerolinea High Identities >=45% antibiotic resistance Ribosomal protein S17P family Firmicutes Thermosinus High Identities >=45% antibiotic resistance Ribosomal protein S4P family Acidobacteria Thermoanaerobaculum_unclassified High Identities >=45% antibiotic resistance Ribosomal protein S5P family Acidobacteria Thermoanaerobaculum_unclassified High Identities >=45% antibiotic resistance RNA polymerase beta' chain family Acidobacteria Candidatus Koribacter_unclassified High Identities >=45% antibiotic resistance RNA polymerase beta chain family Acidobacteria Candidatus Solibacter High Identities >=45% antibiotic resistance RNA polymerase beta chain family Chloroflexi Anaerolinea High Identities >=45% antibiotic resistance RND efflux transporter permease Acidobacteria Thermoanaerobaculum_unclassified High Identities >=45% antibiotic resistance TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EChloroflexi Anaerolinea High Identities >=45% antibiotic resistance TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/ENitrospirae Thermodesulfovibrio_unclassified High Identities >=45% antibiotic resistance TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/ENitrospirae Thermodesulfovibrio_unclassified High Identities >=45% antibiotic resistance Type II topoisomerase family Acidobacteria Thermoanaerobaculum_unclassified High Identities >=45% antibiotic biosynthesis Isocitrate lyase/PEP mutase superfamily Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% PKS,NRPS Mixed trans-AT type I polyketide synthase/nonribosomal peptide synthetase Caldithrix Caldithrix_unclassified Low Identities <45% PKS ABC transporter superfamily Proteobacteria Polyangiaceae Low Identities <45% PKS Aldehyde dehydrogenase family Bacteroidetes Fulvivirga Low Identities <45% PKS Beta-ketoacyl-ACP synthases family Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% PKS Beta-ketoacyl-ACP synthases family Chloroflexi Herpetosiphon Low Identities <45% PKS Class-II pyridoxal-phosphate-dependent aminotransferase family Synergistetes Dethiosulfovibrio Low Identities <45% PKS Enoyl-CoA hydratase/isomerase family environmental samples environmental samples_unclassified Low Identities <45% PKS Modular polyketide synthase Proteobacteria Cystobacteraceae Low Identities <45% PKS Monensin polyketide synthase modules 7 and 8 Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% PKS Polyketide synthase Acidobacteria Granulicella_unclassified Low Identities <45% PKS Polyketide synthase Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% PKS Polyketide synthase Actinobacteria Geodermatophilaceae Low Identities <45% PKS Polyketide synthase Actinobacteria Streptomycetaceae Low Identities <45% PKS Polyketide synthase Armatimonadetes Chthonomonas Low Identities <45% PKS Polyketide synthase Chloroflexi Anaerolinea Low Identities <45% PKS Polyketide synthase Chloroflexi Ktedonobacter Low Identities <45% PKS Polyketide synthase Cyanobacteria Pleurocapsa_unclassified Low Identities <45% PKS Polyketide synthase Deferribacteres Denitrovibrio_unclassified Low Identities <45% PKS Polyketide synthase Deinococcus-Thermus Marinithermus Low Identities <45% PKS Polyketide synthase, enoylreductase Chloroflexi Ktedonobacter Low Identities <45% PKS Polyketide synthase, enoylreductase Cyanobacteria Pleurocapsa_unclassified Low Identities <45% PKS Polyketide synthase environmental samples environmental samples_unclassified Low Identities <45% PKS Polyketide synthase environmental samples environmental samples_unclassified Low Identities <45% PKS Polyketide synthase family protein Actinobacteria Geodermatophilaceae Low Identities <45% PKS Polyketide synthase Firmicutes Exiguobacterium Low Identities <45% PKS Polyketide synthase Proteobacteria Geobacter Low Identities <45% PKS Polyketide synthase Proteobacteria Magnetospirillum Low Identities <45% PKS Polyketide synthase Proteobacteria Myxococcaceae Low Identities <45% PKS Polyketide synthase subunit Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% PKS Polyketide synthase Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% PKS Polyketide synthase Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% PKS Polyketide synthase, type I Deinococcus-Thermus Marinithermus Low Identities <45% PKS Putative Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsD Acidobacteria Candidatus Chloracidobacterium_unclassified Low Identities <45% PKS Putative polyketide synthase Cyanobacteria Oscillatoriales_unclassified Low Identities <45% PKS Putative polyketide synthase PKS Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% PKS Putative polyketide synthase Proteobacteria Bdellovibrio Low Identities <45% PKS Putative polyketide synthase Thaumarchaeota Candidatus Nitrosoarchaeum_unclassified Low Identities <45% PKS Putative polyketide synthase Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% PKS Putative type I polyketide synthase component Proteobacteria Polyangiaceae Low Identities <45% PKS Putative type I polyketide synthase component Verrucomicrobia Verrucomicrobium Low Identities <45% PKS Regulator of polyketide synthase expression Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% PKS Regulator of polyketide synthase expression Chloroflexi Anaerolinea Low Identities <45% PKS Rifamycin polyketide synthase Cyanobacteria Nostoc_unclassified Low Identities <45% PKS Type I polyketide synthase Cyanobacteria Acaryochloris_unclassified Low Identities <45% PKS Type I polyketide synthase Cyanobacteria Chroococcidiopsis_unclassified Low Identities <45% PKS Type I polyketide synthase Cyanobacteria Lyngbya_unclassified Low Identities <45% PKS Type I polyketide synthase Proteobacteria Azoarcus Low Identities <45% PKS Type I polyketide synthase Proteobacteria Myxococcaceae Low Identities <45% NRPS Class-III pyridoxal-phosphate-dependent aminotransferase family Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% NRPS Non-ribosomal peptide synthase Bacteroidetes Rhodothermus_unclassified Low Identities <45% NRPS Non-ribosomal peptide synthase Proteobacteria Pseudomonas Low Identities <45% NRPS Non-ribosomal peptide synthetase Acetothermia Candidatus Acetothermum_unclassified Low Identities <45% NRPS Non-ribosomal peptide synthetase Acidobacteria Candidatus Chloracidobacterium_unclassified Low Identities <45% NRPS Non-ribosomal peptide synthetase Acidobacteria Candidatus Koribacter_unclassified Low Identities <45% NRPS Non-ribosomal peptide synthetase Acidobacteria Candidatus Solibacter Low Identities <45% NRPS Non-ribosomal peptide synthetase Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% NRPS Non-ribosomal peptide synthetase Actinobacteria Streptomycetaceae Low Identities <45% NRPS Non-ribosomal peptide synthetase Bacteria_unclassified Bacteria_unclassified Low Identities <45% NRPS Non-ribosomal peptide synthetase Chloroflexi Roseiflexaceae Low Identities <45% NRPS Nonribosomal peptide synthetase environmental samples environmental samples_unclassified Low Identities <45% NRPS Non-ribosomal peptide synthetase modules and related protein Chloroflexi Roseiflexaceae Low Identities <45% NRPS Non-ribosomal peptide synthetase modules, siderophore biosynthesis Proteobacteria Nannocystaceae Low Identities <45% NRPS Non-ribosomal peptide synthetase Planctomycetes Singulisphaera Low Identities <45% NRPS Non-ribosomal peptide synthetase protein Bacteria_unclassified Bacteria_unclassified Low Identities <45% NRPS Non-ribosomal peptide synthetase Proteobacteria Cystobacteraceae Low Identities <45% NRPS Non-ribosomal peptide synthetase Proteobacteria Nannocystaceae Low Identities <45% NRPS Non-ribosomal peptide synthetase Proteobacteria Polyangiaceae Low Identities <45% NRPS Non-ribosomal peptide synthetase ThaC1 Planctomycetes Singulisphaera Low Identities <45% NRPS Putative non-ribosomal peptide synthetase Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% NRPS Putative non-ribosomal peptide synthetase candidate division NC10 Candidatus Methylomirabilis_unclassified Low Identities <45% NRPS Putative non-ribosomal peptide synthetase Chloroflexi Chloroflexaceae Low Identities <45% NRPS Putative non-ribosomal peptide synthetase Chloroflexi Ktedonobacter Low Identities <45% NRPS Putative non-ribosomal peptide synthetase Cyanobacteria Microcystis_unclassified Low Identities <45% NRPS Putative non-ribosomal peptide synthetase Euryarchaeota Halalkalicoccus Low Identities <45% NRPS Putative non-ribosomal peptide synthetase Firmicutes Clostridium Low Identities <45% NRPS Putative non-ribosomal peptide synthetase Firmicutes Oscillibacter Low Identities <45% NRPS Putative Non-ribosomal peptide synthetase Proteobacteria Ralstonia Low Identities <45% NRPS Yersiniabactin non-ribosomal peptide synthetase Gemmatimonadetes Gemmatimonas_unclassified Low Identities <45% antibiotic resistance ABC transporter ATP-binding protein Acidobacteria Candidatus Koribacter_unclassified Low Identities <45% antibiotic resistance ABC transporter permease Chloroflexi Herpetosiphon Low Identities <45% antibiotic resistance ABC transporter permease Proteobacteria Polynucleobacter Low Identities <45% antibiotic resistance ABC transporter superfamily Acidobacteria Candidatus Koribacter_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Acidobacteria Candidatus Solibacter Low Identities <45% antibiotic resistance ABC transporter superfamily Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Bacteroidetes Parabacteroides Low Identities <45% antibiotic resistance ABC transporter superfamily Chloroflexi Roseiflexaceae Low Identities <45% antibiotic resistance ABC transporter superfamily Cyanobacteria Gloeobacter_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Cyanobacteria Gloeobacter_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Deinococcus-Thermus Marinithermus Low Identities <45% antibiotic resistance ABC transporter superfamily environmental samples environmental samples_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily environmental samples environmental samples_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Firmicutes Clostridium Low Identities <45% antibiotic resistance ABC transporter superfamily Gemmatimonadetes Gemmatimonadetes_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Proteobacteria Escherichia Low Identities <45% antibiotic resistance ABC transporter superfamily Proteobacteria Gammaproteobacteria_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Proteobacteria Nitrosococcus Low Identities <45% antibiotic resistance ABC transporter superfamily Proteobacteria Sphingomonas Low Identities <45% antibiotic resistance ABC transporter superfamily Thaumarchaeota Candidatus Nitrosoarchaeum_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic resistance ABC transporter superfamily Verrucomicrobia Opitutus Low Identities <45% antibiotic resistance AccA family Firmicutes Bacillus Low Identities <45% antibiotic resistance AdeR Proteobacteria Thiohalocapsa Low Identities <45% antibiotic resistance BcrC/YbjG family Deinococcus-Thermus Meiothermus Low Identities <45% antibiotic resistance beta-lactamase Thaumarchaeota Candidatus Nitrosoarchaeum_unclassified Low Identities <45% antibiotic resistance BlaI transcriptional regulatory family Proteobacteria Polyangiaceae Low Identities <45% antibiotic resistance BlaI transcriptional regulatory family Verrucomicrobia Verrucomicrobiales_unclassified Low Identities <45% antibiotic resistance Cft2 Actinobacteria Rubrobacteraceae Low Identities <45% antibiotic resistance Cft2 Firmicutes Symbiobacterium Low Identities <45% antibiotic resistance Chloramphenicol acetyltransferase Bacteroidetes Solitalea Low Identities <45% antibiotic resistance Chloramphenicol acetyltransferase Chloroflexi Anaerolinea Low Identities <45% antibiotic resistance Chloramphenicol acetyltransferase family Bacteroidetes Solitalea Low Identities <45% antibiotic resistance Class-C beta-lactamase family Planctomycetes Planctomyces Low Identities <45% antibiotic resistance Class-C beta-lactamase family Proteobacteria Variovorax Low Identities <45% antibiotic resistance Class-D beta-lactamase family Proteobacteria Deltaproteobacteria_unclassified Low Identities <45% antibiotic resistance Class-I aminoacyl-tRNA synthetase family, IleS type 1 subfamily Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic resistance Class-I aminoacyl-tRNA synthetase family, IleS type 2 subfamily Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% antibiotic resistance Class-I aminoacyl-tRNA synthetase family, IleS type 2 subfamily Firmicutes Eubacterium Low Identities <45% antibiotic resistance DegT/DnrJ/EryC1 family, ArnB subfamily Acetothermia environmental samples_unclassified Low Identities <45% antibiotic resistance DHPS family Aquificae Desulfurobacterium_unclassified Low Identities <45% antibiotic resistance Drug ABC exporter, ATP-binding and membrane-spanning/permease subunit Cyanobacteria Cyanothece_unclassified Low Identities <45% antibiotic resistance Glycosyltransferase 2 family Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% antibiotic resistance Glycosyltransferase 2 family Bacteroidetes Flexibacter Low Identities <45% antibiotic resistance Glycosyltransferase 2 family Chloroflexi Herpetosiphon Low Identities <45% antibiotic resistance Glycosyltransferase 2 family Chloroflexi Sphaerobacteraceae Low Identities <45% antibiotic resistance Glycosyltransferase 2 family Cyanobacteria Crinalium_unclassified Low Identities <45% antibiotic resistance Glycosyltransferase 2 family environmental samples environmental samples_unclassified Low Identities <45% antibiotic resistance Glycosyltransferase 2 family Proteobacteria Pelobacter Low Identities <45% antibiotic resistance Glycosyltransferase 2 family Thaumarchaeota Candidatus Nitrosoarchaeum_unclassified Low Identities <45% antibiotic resistance Glycosyltransferase 2 family Verrucomicrobia Chthoniobacter_unclassified Low Identities <45% antibiotic resistance Isoniazid-induced protein IniA Chloroflexi Caldilinea Low Identities <45% antibiotic resistance lipid A export ATP-binding/permease Proteobacteria Candidatus Entotheonella_unclassified Low Identities <45% antibiotic resistance lipid A export ATP-binding/permease Proteobacteria Myxococcaceae Low Identities <45% antibiotic resistance Metallo-beta-lactamase superfamily, Class-B beta-lactamase family Proteobacteria Simiduia_unclassified Low Identities <45% antibiotic resistance Multiple antibiotic resistance protein MarR Gemmatimonadetes Gemmatimonas_unclassified Low Identities <45% antibiotic resistance OmpR family transcriptional regulator Firmicutes Clostridium Low Identities <45% antibiotic resistance OmpR family transcriptional regulator Proteobacteria sulfur-oxidizing symbionts_unclassified Low Identities <45% antibiotic resistance OmpR family transcriptional regulator Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic resistance outer membrane efflux protein Proteobacteria Sphingomonas Low Identities <45% antibiotic resistance Peptidase S45 family Deinococcus-Thermus Truepera Low Identities <45% antibiotic resistance periplasmic multidrug efflux lipoprotein Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% antibiotic resistance putative cation efflux system protein Proteobacteria Myxococcaceae Low Identities <45% antibiotic resistance RecName: Full=Transcriptional activator RamA Bacteroidetes Bacteroides Low Identities <45% antibiotic resistance Regulatory protein VanR Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% antibiotic resistance Response regulator protein VraR Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% antibiotic resistance Response regulator protein VraR Chloroflexi Ktedonobacter Low Identities <45% antibiotic resistance Response regulator protein VraR Chloroflexi Sphaerobacteraceae Low Identities <45% antibiotic resistance Response regulator protein VraR Chloroflexi Thermomicrobium_unclassified Low Identities <45% antibiotic resistance Response regulator protein VraR Firmicutes Ruminiclostridium Low Identities <45% antibiotic resistance Response regulator protein VraR Gemmatimonadetes Gemmatimonadetes_unclassified Low Identities <45% antibiotic resistance response regulator Proteobacteria Polyangiaceae Low Identities <45% antibiotic resistance Ribosomal protein L11P family Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic resistance Ribosomal protein L6P family candidate division NC10 Candidatus Methylomirabilis_unclassified Low Identities <45% antibiotic resistance Ribosomal protein S4P family Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic resistance RNA methyltransferase TsnR/AvirB family Firmicutes Acetohalobium Low Identities <45% antibiotic resistance RNA polymerase beta chain family Thaumarchaeota Candidatus Nitrosoarchaeum_unclassified Low Identities <45% antibiotic resistance RND efflux membrane fusion protein Proteobacteria Myxococcaceae Low Identities <45% antibiotic resistance RND efflux transporter permease Proteobacteria Hydrocarboniphaga Low Identities <45% antibiotic resistance TcaA family Spirochaetes Treponema_unclassified Low Identities <45% antibiotic resistance TehB family Planctomycetes Rhodopirellula Low Identities <45% antibiotic resistance TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EAcidobacteria Thermoanaerobaculum_unclassified Low Identities <45% antibiotic resistance TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, TetM/TPlanctomycetes Rhodopirellula Low Identities <45% antibiotic resistance TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, TetM/TThermodesulfobacteria Thermodesulfatator_unclassified Low Identities <45% antibiotic resistance Transferase hexapeptide repeat family, LpxD subfamily Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% antibiotic resistance Transmembrane ATP-binding ABC transporter protein Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% antibiotic resistance Transpeptidase family Proteobacteria Geobacter Low Identities <45% antibiotic resistance two-component response regulator Proteobacteria Gammaproteobacteria_unclassified Low Identities <45% antibiotic resistance Type III pantothenate kinase family Firmicutes Thermacetogenium Low Identities <45% antibiotic resistance VanRG Thaumarchaeota unclassified Thaumarchaeota_unclassified Low Identities <45% antibiotic resistance VanRM Chloroflexi Anaerolinea Low Identities <45% antibiotic resistance VanSM Proteobacteria Gammaproteobacteria_unclassified Low Identities <45% antibiotic resistance VanSst Verrucomicrobia Opitutus Low Identities <45% antibiotic resistance VanTG Firmicutes Caldicellulosiruptor Low Identities <45% antibiotic resistance Vgb family Proteobacteria Myxococcaceae Low Identities <45% antibiotic biosynthesis,PKS SchB/CurC family Actinobacteria Streptomycetaceae Low Identities <45% antibiotic biosynthesis Anthranilate synthase component I family Thaumarchaeota Candidatus Nitrosoarchaeum_unclassified Low Identities <45% antibiotic biosynthesis Bacterial non-heme bromo- and chloro-peroxidases family Chloroflexi Anaerolinea Low Identities <45% antibiotic biosynthesis Class-II pyridoxal-phosphate-dependent aminotransferase family Acidobacteria Candidatus Chloracidobacterium_unclassified Low Identities <45% antibiotic biosynthesis Class-V pyridoxal-phosphate-dependent aminotransferase family Proteobacteria Desulfomonile Low Identities <45% antibiotic biosynthesis Cysteine synthase/cystathionine beta-synthase family Bacteroidetes Sphingobacterium Low Identities <45% antibiotic biosynthesis Cysteine synthase/cystathionine beta-synthase family Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic biosynthesis Cytochrome P450 family Planctomycetes Singulisphaera Low Identities <45% antibiotic biosynthesis DegT/dnrJ/eryC1 family Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic biosynthesis Dehydroquinate synthase family, DOI synthase subfamily Acidobacteria Terriglobus_unclassified Low Identities <45% antibiotic biosynthesis DTDP-4-dehydrorhamnose reductase family Euryarchaeota Methanoculleus Low Identities <45% antibiotic biosynthesis DTDP-4-dehydrorhamnose reductase family Firmicutes Clostridiaceae_unclassified Low Identities <45% antibiotic biosynthesis Glucose-1-phosphate thymidylyltransferase family Actinobacteria Micromonosporaceae Low Identities <45% antibiotic biosynthesis Glycosyltransferase group 1 family Bacteroidetes Microscilla Low Identities <45% antibiotic biosynthesis Glycosyltransferase group 1 family Proteobacteria Ectothiorhodospira Low Identities <45% antibiotic biosynthesis Glycosyltransferase group 1 family Proteobacteria Halorhodospira Low Identities <45% antibiotic biosynthesis Lincomycin biosynthesis protein LmbN Chloroflexi Anaerolinea Low Identities <45% antibiotic biosynthesis Methyltransferase superfamily, DnrC family Firmicutes Sporolactobacillus Low Identities <45% antibiotic biosynthesis Methyltransferase superfamily, DnrC family Proteobacteria Chelativorans Low Identities <45% antibiotic biosynthesis Methyltransferase superfamily, DnrC family Proteobacteria Halomonas Low Identities <45% antibiotic biosynthesis Methyltransferase superfamily, DnrC family Thaumarchaeota Candidatus Nitrosoarchaeum_unclassified Low Identities <45% antibiotic biosynthesis Methyltransferase superfamily Firmicutes Desmospora Low Identities <45% antibiotic biosynthesis Methyltransferase superfamily Firmicutes Sporolactobacillus Low Identities <45% antibiotic biosynthesis Methyltransferase superfamily Proteobacteria Chelativorans Low Identities <45% antibiotic biosynthesis Methyltransferase superfamily Proteobacteria Halomonas Low Identities <45% antibiotic biosynthesis Methyltransferase superfamily Proteobacteria Thioalkalivibrio Low Identities <45% antibiotic biosynthesis Methyltransferase superfamily Thaumarchaeota Candidatus Nitrosoarchaeum_unclassified Low Identities <45% antibiotic biosynthesis Methyltransferase TylM1/DesVI family Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic biosynthesis NodU/CmcH family Proteobacteria Desulfocapsa Low Identities <45% antibiotic biosynthesis Peptidase M16 family Acidobacteria Candidatus Chloracidobacterium_unclassified Low Identities <45% antibiotic biosynthesis RelA/SpoT family Acidobacteria Candidatus Koribacter_unclassified Low Identities <45% antibiotic biosynthesis RelA/SpoT family Chloroflexi Anaerolinea Low Identities <45% antibiotic biosynthesis TAL/TAM family Acidobacteria Thermoanaerobaculum_unclassified Low Identities <45% antibiotic biosynthesis Terpene synthase family Armatimonadetes Chthonomonas Low Identities <45% antibiotic biosynthesis TrpC family Proteobacteria Comamonadaceae_unclassified Low Identities <45% antibiotic biosynthesis TrpC family Thaumarchaeota Nitrosopumilus_unclassified Low Identities <45% antibiotic biosynthesis Zinc-containing alcohol dehydrogenase family, DOIA dehydrogenase subfamily Proteobacteria Methylomonas Table S2.4. Metagenomic contigs associated with enzymes involved in antibiotic synthesis and resistance and the species from which they are derived.
MMK MNR MMR MNK Proteobacteria 31 113 32 310 Bacteroidetes 6 85 79 77 Acidobacteria 5 2 1 10 Firmicutes 13 29 12 81 Cyanobacteria 4 28 24 20 Chloroflexi 9 4 1 17 Gemmatimonadetes 2 3 2 3 Actinobacteria 1 7 1 33 Planctomycetes 3 7 2 8
Table S2.4i. Metagenomic contigs associated with enzymes involved in antibiotic resistance and the species from which they are derived.
MMK MNR MMR MNK Proteobacteria 14 39 19 155 Bacteroidetes 2 31 31 40 Acidobacteria 4 0 1 4 Firmicutes 3 7 4 45 Cyanobacteria 0 16 10 25 Chloroflexi 1 3 2 12 Gemmatimonadetes 0 2 0 2 Actinobacteria 2 2 2 22 Planctomycetes 1 2 3 6
Table S2.4ii. Metagenomic contigs associated with enzymes involved in antibiotic and the species from which they are derived.
Table S2.5. Metagenomic contigs associated with PKS and NRPS enzymes and the species from which they are derived
MMK MNR MMR MNK Proteobacteria 9 42 14 205 Bacteroidetes 2 43 37 38 Acidobacteria 3 4 2 6 Firmicutes 1 17 2 36 Cyanobacteria 7 13 13 14 Chloroflexi 3 4 1 12 Gemmatimonadetes 0 1 0 3 Actinobacteria 2 5 1 26 Planctomycetes 0 4 4 5
Table S2.5i. Metagenomic contigs associated with PKS enzymes and the species from which they are derived
MMK MNR MMR MNK Proteobacteria 7 32 11 107 Bacteroidetes 1 39 32 28 Acidobacteria 4 2 0 2 Firmicutes 2 7 0 19 Cyanobacteria 1 13 8 14 Chloroflexi 3 1 1 8 Gemmatimonadetes 1 1 1 2 Actinobacteria 1 1 1 15 Planctomycetes 1 1 1 4
Table S2.5ii. Metagenomic contigs associated with NRPS enzymes and the species from which they are derived
Table S3.1. Morphological distinctiveness- SPSS
Descreption Sample ID type of Color Shape Size Surface Elevation Texture Location Media sediments Bac 1 Creamy irregular small smooth flat moist R MN 1 Medium # Bac2 Beige irregular small smooth convex moist R MN 1 MA 2216 1 Bac 3 Brown circular micro smooth flat moist R MN 1 10% MA 2216 2 Bac4 Creamy irregular small rough convrx moist R MN 3 AIA 3 Bac5 Creamy circular small smooth convex moist R MN 3 Anti- MA 2216 4 Bac7 Creamy circular small smooth convex moist R MN 1 MA-GM 5 Bac9 Creamy circular small smooth convex moist R MN 1 Bac13 Creamy circular small smooth convex moist R MN 1 Location Bac16 Peach circular small smooth convex moist R MN 5 Rabigh R Bac17 Beige circular small smooth convex moist R MN 5 Al-Kharrar K Bac18 Pink circular large smooth convex moist R MN 5 Bac21 White circular small smooth convex moist R MN 5 Bac22 Ligh Pink irregular small rough convex moist R MN 5 Bac24 Peach circular large smooth convex moist R MN 5 Bac26 Creamy rhizoid small rough flat moist R MN 5 Bac27 Peach irregular small smooth convex moist R MN 5 Bac28 Clear circular large smooth raised moist R MN 5 Bac29 Brown circular small smooth convex moist R MN 2 Bac32 Beige circular small smooth convex moist R MN 2 Bac34 Creamy circular small smooth convex moist R MN 2 Bac35 Beige irregular small smooth flat moist R MN 2 Bac37 Beige circular small smooth flat moist R MN 2 Bac41 Yellow circular large smooth convex moist R MN 3 Bac42 Yellow circular micro smooth convex moist R MN 3 Bac46 Creamy circular small smooth convex moist R MN 3 Bac49 Creamy circular large rough flat moist R MN 3 Bac53 Beige circular small smooth flat moist R MN 3 Bac54 Brown circular small smooth flat moist R MN 1 Bac56 Beige circular large smooth flat moist R MN 2 Bac57 Beige circular small smooth convex moist R MN 5 Bac58 Peach circular small smooth convex moist R MM 1 Bac59 White circular small rough flat dry R MM 1 Bac60 Creamy circular small smooth convex moist R MM 1 Bac61 Creamy circular small smooth convex moist R MM 1 Bac62 Light Pink circular small rough flat dry R MM 5 Bac63 Pink circular small smooth convex moist R MM 5 Bac66 Creamy irregular small smooth convex moist R MM 3 Bac67 Creamy circular micro smooth convex moist R MM 4 Bac69 Creamy irregular small rough flat dry R MM 3 Bac71 Pink circular large rough flat dry R MM 1 Bac74 Pink irregular small rough flat moist R MM 1 Bac75 Light Pink circular small rough flat moist R MM 5 Bac76 Creamy circular large rough flat dry R MM 5 Bac77 Creamy circular small smooth flat moist R MM 1 Bac78 Creamy irregular largee wrinkled flat moist R MM 5 Bac79 Creamy circular small smooth convex viscous R MM 5 Bac80 Creamy rhizoid small rough convex moist R MM 5 Bac81 Clear circular large smooth flat moist R MM 2 Bac82 Creamy circular small smooth convex moist R MM 2 Bac83 Creamy circular small smooth convex moist R MM 2 Bac84 White circular small rough flat dry R MM 5 Bac85 Creamy circular large rough flat dry R MM 1 Bac87 Beige circular small rough stick on media dry R MM 1 Bac90 Creamy irregular small Rough raised moist R MM 2 Bac92 Orange circular small smooth flat moist R MM 4 Bac93 Creamy circular small smooth convex moist R MM 4 Bac94 Orange circular small smooth convex moist R MM 1 Bac95 Clear circular small smooth convex moist R MM 5 Bac96 Creamy circular small smooth flat moist R MM 5 Bac97 White circular micro smooth flat moist R MM 3 Bac98 Clear circular small smooth convex viscous R MM 3 Bac105 Pink irregular small rough convex dry R MM 5 Bac106 Peach irregular small smooth convex moist R MM 3 Bac109 Creamy circular small smooth convex moist R MM 3 Bac110 White circular micro smooth flat moist R MM 3 Bac111 Pink filamentous small smooth convex moist R MM 5 Bac115 Pink circular small smooth convex moist R MM 5 Bac116 Peach circular micro smooth flat moist R BS 1 Bac117 Creamy circular micro smooth flat moist R BS 1 Bac118 Orange circular micro smooth flat moist R BS 1 Bac119 Light pink circular micro smooth flat moist R BS 1 Bac120 White circular small smooth convex moist R BS 1 Bac121 Creamy circular small smooth flat moist R BS 5 Bac122 Peach circular small smooth convex moist R BS 5 Bac123 Orange circular small smooth convex moist R BS 3 Bac127 Pink circular small rough convex dry R BS 1 Bac128 Peach circular micro smooth convex moist R BS 2 Bac129 Yellow circular micro smooth convex moist R BS 2 Bac130 Orange circular micro smooth convex moist R BS 2 Bac131 Peach circular small smooth convex moist R BS 4 Bac132 Clear circular micro smooth flat moist R BS 3 Bac133 Pech circular small smooth flat moist R BS 3 Bac134 Creamy circular small smooth flat moist R BS 3 Bac135 Creamy circular mico smooth flat moist R BS 3 Bac139 Creamy circular small rough flat dry R BS 2 Bac140 Yellow circular small smooth convex moist R BS 2 Bac142 Pink irrgular small rough flat dry R BS 5 Bac143 Creamy circular mico smooth convex moist R BS 5 Bac144 Beige irrgular mico smooth flat moist R BS 5 Bac145 Clear circular mico smooth flat moist R BS 5 Bac147 Creamy circular mico smooth flat moist R BS 5 Bac151 Yellow circular small smooth convex moist R BS 1 Bac155 White circular small smooth flat moist R BS 1 Bac156 White circular micro smooth flat moist R BS 2 Bac162 Creamy circular mico smooth convex moist R BS 5 Bac163 Peach filamentous small smooth convex moist R BS 5 Bac164 Peach filamentous small smooth convex moist R BS 5 Bac165 White circulsr micro smooth flat moist R BS 2 Bac166 Pink rhizod small rough convex moist R BS 5 Bac167 White circular small smooth flat moist R BS 3 Bac168 Beige circular small smooth flat moist R BS 3 Bac171 White circular small smooth flat moist R BS 2 Bac173 Creamy circular small smooth convex moist K MN 1 Bac174 Orange circular small smooth convex moist K MN 1 Bac175 Black circular small smooth convex moist K MN 4 Bac176 Creamy circular small smooth convex moist K MN 4 Bac177 Light Yellow irrgular micro smooth flat moist K MN 2 Bac178 White circular small smooth convex moist K MN 2 Bac179 Yellow circular small smooth convex moist K MN 2 Bac183 Creamy circular small smooth flat moist K MN 3 Bac185 Yellow circular small smooth convex moist K MN 2 Bac189 Pink irrgular small rough flat moist K MN 5 Bac190 White circular small smooth flat moist K MN 5 Bac194 Orange circular small smooth convex moist K MN 2 Bac197 Yellow circular small smooth flat moist K MN 2 Bac198 Yellow circular small smooth convex moist K MN 1 Bac200 Creamy circular small smooth flat moist K MN 5 Bac201 Clear circular small smooth convex moist K MN 5 Bac202 Pink circular small smooth convex moist K MN 1 Bac203 Yellow circular small smooth convex moist K MN 1 Bac204 Creamy circular small smooth flat moist K MN 1 Bac208 Creamy circular small smooth flat moist K MN 3 Bac209 Peach circular small smooth flat moist K MN 5 Bac210 Pink irregular small rough flat dry K MN 5 Bac213 Orange circular small smooth flat moist K MM 5 Bac214 Clear irregular small smooth flat viscous K MM 5 Bac216 Yellow circular small smooth convex moist K MM 2 Bac217 Creamy circular small smooth convex moist K MM 2 Bac218 Creamy circular large smooth flat moist K MM 5 Bac219 Orange circular large smooth flat moist K MM 5 Bac220 Creamy rhizoid small rough flat dry K MM 3 Bac231 Orange circular small smooth convex moist K MM 1 Bac241 Creamy circular small smooth flat moist K BS 1 Bac242 Brown circular small smooth flat moist K BS 1 Bac243 Peach circular small smooth convex moist K BS 1 Bac244 Creamy circular small smooth convex moist K BS 1 Bac245 Creamy circular micro smooth flat moist K BS 2 Bac246 White circular lage smooth flat lage moist K BS 2 Bac247 Light Pink circular small rough stick on media dry K BS 3 Bac248 Light Pink Irregular small smooth stick on media moist K BS 3 Bac249 Creamy circular micro smooth convex moist K BS 1 Bac250 Pink Irrgular Irrgular wrinkle smooth flat moist K BS 1 Bac251 White circular small smooth convex moist K BS 2 Bac252 Beige circular small smooth convex moist K BS 2 Bac253 White wrinkled large smooth flat moist K BS 2 Bac254 Peach rhizoid small rough convex viscus K MN 5 Bac255 White circular small smooth flat moist K MN 5 Bac256 Peach circular large smooth flat moist K MN 5 Bac257 Peach circular large media smooth flat viscus K MN 1 Bac260 Creamy circular micro smooth flat moist K MN 1 Bac261 Brown circular micro smooth flat moist K MN 2 Bac265 Pink circular small rough flat moist K MM 3 Bac267 Peach circular small smooth convex moist K MM 5 Bac268 Clear irrgular large smooth flat moist K MM 5 Bac269 Peach irrgular large smooth flat moist K MM 5 Bac270 White circular small smooth convex moist K MM 2 Bac271 Orange circular micro smooth convex moist K MM 2 Bac272 Creamy circular small rough stick on media dry K MM 1 Bac273 Clear circular large smooth convex moist K MM 1 Bac274 White circular microcolny smooth flat moist K BS 2 Bac275 White circular microcolny smooth flat moist K BS 2 Bac277 White circular microcolny smooth flat moist K BS 3 Bac278 Pink circular small smooth convex moist K BS 3 Bac279 white circular small smooth convex moist K BS 1 Bac280 Beige circular small smooth convex moist K BS 1 Bac282 Clear filamitous small smooth convex moist K BS 5 Bac283 Pink rhizoid small rough convex moist K BS 5 Bac284 White circular small rough stick on media moist K BS 3 Bac287 White circular micro smooth flat moist K BS 2 Bac288 White circular micro smooth flat moist K BS 2 Bac289 Pink irrgular large rough convex moist K BS 5 Bac291 Pink irrgular large smooth flat moist K BS 2 Bac292 Creamy circular micro smooth convex moist K BS 2 Bac295 White circular small smooth flat moist K BS 5 Bac296 Pink circular small smooth convex moist K BS 5 Bac298 Creamy circular small smooth convex moist K MM 5 Bac299 Orange circular small smooth convex moist K MM 5 Bac301 Creamy circular small smooth flat moist K MM 1 Bac302 Creamy rhizod small rough flat moist K MM 2 Bac306 Creamy circular small smooth convex moist K MN 1 Bac318 Creamy circular small smooth convex moist R MM 1 Bac320 Clear Irrgular micro smooth flat moist R MM 5 Bac323 White irrgular small smooth flat moist R MN 5 Bac324 Orange circular small smooth convex moist R MN 5 Bac325 Orange circular small smooth convex moist R MN 5 Bac327 White circular small smooth flat moist R MN 5 Bac330 Light circular small smooth convex moist R MN 1 Bac334 Yellow circular small smooth convex moist R BS 3 Bac335 Creamy circular small smooth convex moist R BS 3 Bac336 White circular small smooth convex moist R BS 1 Bac337 White circular small smooth convex moist R BS 1 Bac338 White circular small smooth convex moist R BS 2 Bac342 White circular small smooth convex moist K BS 2 Bac344 Creamy circular small smooth convex moist R BS 5 Bac345 Clear Irrgular small smooth flat moist R BS 5 Bac351 Yellow circular small smooth flat moist K MN 5 Bac353 Creamy circular small smooth flat moist K MN 3 Bac355 Light Pink Irrgular small smooth flat moist K BS 5 Bac358 White circular micro smooth convex moist K BS 2 Bac361 Creamy circular small smooth convex moist K BS 1 Bac363 Clear circular micro smooth convex moist K MM 5 Bac366 Creamy circular small smooth flat moist K MM 3 Bac371 Creamy circular small smooth convex moist K MM 1 Bac372 Clear circular small smooth convex moist R BS 5 Bac373 White circular small smooth flat moist R BS 5 Bac374 Creamy circular small smooth convex moist R BS 3 Bac375 Creamy circular small smooth flat moist R BS 3 Bac376 Creamy circular small smooth convex moist R BS 1 Bac378 Clear circular small smooth convex moist R BS 2 Bac381 Light Pink circular small smooth convex moist R MM 5 Bac383 Creamy circular small smooth flat moist R MM 1 Bac384 Creamy circular small smooth convex moist R MM 1 Bac387 Creamy circular small smooth flat moist R MN 1 Bac389 Light Pink circular small smooth convex moist R MN 5 Bac390 Light Pink circular small smooth convex moist R MN 5 Bac391 Creamy circular micro smooth convex moist R MN 2 Table S5.1. Detailed information about all bacterial isolates. 16S rRNA seq. (from NCBI) PKS/NRPS Coculturing (Annular radius) mm Isolation Sample ID Type of samples Description Staphylococcus media Closest Relative by BLAST and %Sequence NRPS(A7R/A3F) 700- PKS1(K1F/M6R)1250- PKS2(KSα, KSβ) 800- Salmonella Pseudomonas Escherichia coli Accession Phylum aureus Similarity 800bp 1400bp 900bp typhimurium (dt2) syringae (dc3000) (dh5 α) (ATCC25923) Bac 1 MN/R 1 creamy ,flat, smooth, irregular, moist 99% Vibrio parahaemolyticus KC210812.1 Proteobacteria + - + - - - -
Bac2 MN/R 1 Beige, convex, smooth, irregular, moist 99%Vibrio parahaemolyticus KC884652.1 Proteobacteria + - + - - - -
Bac 3 MN/R 1 Brown, microcolony, smooth, circular flat , moist 99% Vibrio harveyi AB617569.1 Proteobacteria + ------
Bac4 MN/R 3 creamy,irregular,rough, convrx, moist 99% Bacillus licheniformis KC514131.1 Firmicutes + + - 1 - - -
Bac5 MN/R 3 creamy,smooth, convex, circular, moist 99% Bacillus licheniformis HE995760.1 Firmicutes + - - 0.5 - 2.5 1
Bac7 MN/R 1 creamy, circular,smooth, convex, moist 99% Vibrio alginolyticus JF784015.1 Proteobacteria ------
Bac9 MN/R 1 creamy,smooth, convex, circular, moist 99% Vibrio harveyi AB617569.1 Proteobacteria ------Bac13 MN/R 1 creamy, circular,smooth, convex, moist 99% Vibrio alginolyticus KF443081.1 Proteobacteria 47% hypothetical protein [Marinobacter + + - - - - manganoxydans] WP_008171913.1
Bac16 MN/R 5 Peach,circular smooth, convex, moist 99% Vibrio furnissii FJ906812.1 Proteobacteria - + - - - - -
Bac17 MN/R 5 Clear Beige,circular smooth, convex, moist 99% Vibrio furnissii FJ906812.1 Proteobacteria ------
Bac18 MN/R 5 Clear Pink, smooth, larg colony, convex, circular, moist 99% Vibrio alginolyticus JN188411.1 Proteobacteria ------
Bac21 MN/R 5 white, circular smooth, convex, moist 99% Virgibacillus pantothenticus JN791392.1 Firmicutes ------
Bac22 MN/R 5 Ligh Pink, irregular,rough,convex, moist 99% Virgibacillus pantothenticus JN791392.2 Firmicutes ------
Bac24 MN/R 5 Peach, huge colony, smooth, convex, circular , moist 99% Virgibacillus dokdonensis JN903905.1 Firmicutes ------
Bac26 MN/R 5 creamy,rhizoid, rough, circular, moist 99% Bacillus subtilis JX994100.1 Firmicutes 99% polyketide + synthase [Bacillus] + - - - - WP_029973687.1
Bac27 MN/R 5 Peach, smooth, convex, irregular, moist 99% Vibrio furnissii FJ906812.1 Proteobacteria ------
Bac28 MN/R 5 Clear,smooth, large colony, moist, raised 99% Vibrio alginolyticus JF784015.1 Proteobacteria ------
Bac29 MN/R 2 Brown, smooth, circular convex, moist 99% Microbulbifer salipaludis NR_025232.1 Proteobacteria ------
Bac30 MN/R 2 white, circular smooth, convex, moist 99% Vibrio alginolyticus JF784015.1 Proteobacteria ------
Bac32 MN/R 2 light brown, circular smooth, convex , moist 99%Microbulbifer gwangyangensis JX628583.1 Proteobacteria ------
Bac33 MN/R 2 white, microcolony, circular, smooth, flat, moist 99% Microbulbifer variabilis JN128259.1 Proteobacteria ------
Bac34 MN/R 2 creamy, circular,smooth, convex, moist 98% Vibrio alginolyticus JF784015.1 Proteobacteria ------
Bac35 MN/R 2 light brown, flat, smooth, irregular , moist 99% Microbulbifer maritimus JQ824943.1 Proteobacteria ------
Bac37 MN/R 2 Beige, flat, smooth, circular, moist 99% Vibrio alginolyticus CP006718.1 Proteobacteria ------
Bac38 MN/R 3 white,irregular, flat, rough, moist 99% Bacillus foraminis NR_042274.1 Firmicutes ------
Bac39 MN/R 3 white, circular smooth, convex, moist 99% Bacillus foraminis NR_042274.1 Firmicutes ------
Bac41 MN/R 3 creamy Yellowish, large colony, circular smooth, convex, 99% Gordonia terrae EU333873.1 Actinobacteria ------moist Bac42 MN/R 3 Yellow, microcolony, circular convex, smooth, moist 99% Gordonia terrae EU333873.1 Actinobacteria ------
Bac44 MN/R 3 Clear, microcolony, smooth, circular, moist 99% Bacillus foraminis NR_042274.1 Firmicutes + - + - - - -
Bac45 MN/R 3 white, microcolony, circular smooth , cluster, moist 99% Bacillus foraminis NR_042274.1 Firmicutes - - + - - - -
Bac46 MN/R 3 creamy, circular,smooth, convex, moist 99% Isoptericola chiayiensis FJ469988.1 Actinobacteria ------
Bac47 MN/R 3 white, microcolony, circular, smooth, convex, moist 99% Bacillus licheniformis JQ236634.1 Firmicutes ------
Bac48 MN/R 3 Clear,smooth, circular, convex, moist 99% Bacillus aerius KC443101.1 Firmicutes ------
Bac49 MN/R 3 creamy, flat, rough, large colony, moist 99% Bacillus licheniformis HE995760.1 Firmicutes ------
Bac50 MN/R 3 white,large colony, smooth, flat, moist 99% Bacillus subtilis HF563562.1 Firmicutes ------Bac52 MN/R 3 white,filamontous, rough, circular, moist 99% Bacillus vallismortis KC441761.1 Firmicutes ------
Bac53 MN/R 3 Beige,flat , smooth ,circular, moist 99% Microbulbifer maritimus NR_025772.1 Proteobacteria ------
Bac54 MN/R 1 Brown,flat , smooth ,circular, moist 99% Microbulbifer maritimus NR_025772.1 Proteobacteria ------
Bac55 MN/R 2 white, irrgular , flat , moist 99% Bacillus aquimaris GQ927174.1 Firmicutes ------
Bac56 MN/R 2 Beige, flat , large colony, moist 98% Microbulbifer maritimus NR_025772.1 Proteobacteria ------
Bac57 MN/R 5 Beige, circular, convex, smooth, moist 99% Bacillus amyloliquefaciens JQ693000.1 Firmicutes - - - - - 5 -
Bac58 MM/R 1 Peach,circular, smooth, convex, moist 99% Salinivibrio costicola JX913853.1 Proteobacteria ------
Bac59 MM/R 1 white, circular, flat, rough,dry 99% Pseudoalteromonas piscicida AF081498.1 Proteobacteria ------
Bac60 MM/R 1 Creacmy,circular, smooth, convex, moist 99% Salinivibrio costicola JX913853.1 Proteobacteria ------
Bac61 MM/R 1 Creacmy,circular, smooth, convex, moist 99% Virgibacillus pantothenticus AB617570.1 Firmicutes ------
Bac62 MM/R 5 ight Pink, circular, rough, flat, dry 99% Saccharospirillum salsuginis NR_044132.1 Proteobacteria ------
Bac63 MM/R 5 Pink,smooth, convex, circular, moist 99% Psychrobacter celer JQ799068.1 Proteobacteria ------
Bac66 MM/R 3 creamy,Irregular, smooth, convex, moist 99% Psychrobacter celer JQ799068.1 Proteobacteria ------
Bac67 MM/R 4 creamy, microcolony,circular, smooth, convex, moist 99%Blastopirellula cremea JF443747.1 Planctomycete ------
Bac69 MM/R 3 creamy,Irregular, circular, rough, flat, dry 99% Psychrobacter celer JQ799068.1 Proteobacteria ------
Bac70 MM/R 3 white, circular, smooth, convex, moist 99% Psychrobacter celer JQ799068.1 Proteobacteria ------Bac71 MM/R 1 Pink, rough, flat, large colony, dry 99% Bacillus sonorensis KTT-24 HQ696443.1 Firmicutes 95% non-ribosomal peptide synthase + - - - - - [Bacillus subtilis] KIN39535.1
Bac74 MM/R 1 Pink, rough, flat,irregular 99% Bacillus licheniformis HM629383.1 Firmicutes ------
Bac75 MM/R 5 ight Pink, circular, rough, flat 99% Virgibacillus dokdonensis EU368764.1 Firmicutes - - - 1 - 1 -
Bac76 MM/R 5 creamy, rough, flat, large colony, dry 99% Virgibacillus dokdonensis EU368764.1 Firmicutes ------
Bac77 MM/R 1 creamy, circular, smooth, flat, moist 99% Pseudoalteromonas flavipulchra NR_025126.1 Proteobacteria ------
Bac78 MM/R 5 creamy, wrinkled, flat, large colony, smooth 99% Virgibacillus dokdonensis JN903905.1 Firmicutes ------
Bac79 MM/R 5 creamy, smooth, convex, circular, viscous 99% Bacillus sonorensis HQ696443.1 Firmicutes ------
Bac80 MM/R 5 creamy, , rough, rhizoid, convex 99% Bacillus sonorensis HQ696443.1 Firmicutes ------
Bac81 MM/R 2 Clear, smooth,large colony, flat, moist 99% Vibrio harveyi FJ154796.1 Proteobacteria ------
Bac82 MM/R 2 creamy,circular,smooth, convex, moist 99%Pseudoalteromonas shioyasakiensis. NR_125458.1 Proteobacteria + - + - - - -
Bac83 MM/R 2 creamy,circular,smooth, convex, moist 99% Salinivibrio costicola JX913853.1 Proteobacteria + ------Bac84 MM/R 5 white ,circular, rough, dry,flat 99% Bacillus licheniformis HQ143636.1 Firmicutes 95% non-ribosomal 74% hypothetical peptide synthetase protein [Bacillus [Bacillus sp. + 4.5 3 3 3 subtilis] MSP5.4]WP_039073180 WP_015252614.1 .1 Bac85 MM/R 1 creamy, large colony, flat, rough, dry 95%Microbulbifer gwangyangensis JX628583.1 Proteobacteria + - + - - - -
Bac87 MM/R 1 Beige,circular , flat, under media 99% Marinobacter hydrocarbonoclasticus JN160753.1 Proteobacteria ------
Bac90 MM/R 2 Pink, circular, smooth, convex, moist 99% Bacillus sonorensis JN700092.1 Firmicutes - - - 3.75 2.75 3 3 Bac92 MM/R 4 Orange, circular, smooth, flat, moist 97% Planctomyces brasiliensis NR_074297.1 Planctomycetes 50% hypothetical 86% hypothetical protein [Blastopirellula protein [Rubinisphaera + - - - - marina] brasiliensis] WP_040351748.1 WP_013627469.1
Bac93 MM/R 4 creamy, circular, smooth, convex, moist 99% Blastopirellula cremea NR_118153.1 Planctomycetes - + + - - - -
Bac94 MM/R 1 Orange, circular,smooth, convex, moist 98% Bacillus simplex EU221357.1 Firmicutes - + - - - - -
Bac95 MM/R 5 Clear, smooth, circular, convex, moist 99% Bacillus vallismortis NR_024696.1 Firmicutes ------Bac96 MM/R 5 creamy, flat, smooth, , moist, circular 99% Bacillus licheniformis HQ143566.1 Firmicutes ------
Bac97 MM/R 3 white, microcolony, circular, flat , moist 99% Bacillus vallismortis HQ992817.1 Firmicutes ------
Bac98 MM/R 3 Clear, circular, smooth, convex, viscous 99% Brevibacillus borstelensis KC503891.1 Firmicutes - - - 5 0.5 4.25 4
Bac105 MM/R 5 Dark pink, irregular, rough, convex 99% Bacillus vallismortis NR_024696.1 Firmicutes ------
Bac106 MM/R 3 Peach,irregular, smooth, convex, moist 99% Bacillus vallismortis NR_024696.1 Firmicutes + ------
Bac109 MM/R 3 creamy, circular, smooth, convex, moist 99% Brevibacillus borstelensis AB680943.1 Firmicutes + ------
Bac110 MM/R 3 white, flat, microcolony, moist, smooth 99% Brevibacillus borstelensis KC503891.1 Firmicutes ------Bac111 MM/R 5 Clear Pink, convex, filamentous, moist, smooth 99% Bacillus vallismortis NR_024696.1 Firmicutes 78% non-ribosomal 89% hypothetical 99%hypothetical peptide synthetase protein [Bacillus protein [Paenibacillus 2 4 0.5 5 [Paenibacillus elgii] thuringiensis] dendritiformis] WP_050900668.1 KKB27200.1 WP_006677536.1
Bac115 MM/R 5 Clear Pink, circular, smooth, convex , moist 99% Bacillus axarquiensis JF414764.1 Firmicutes ------
Bac116 BS/R 1 Peach, microcolony, circular, smooth, flat, moist 99% Bacillus sonorensis HM854235.1 Firmicutes ------
Bac117 BS/R 1 Creamy, microcolony, circular, smooth, flat, moist 99% Bacillus oceanisediminis JF411237.1 Firmicutes ------
Bac118 BS/R 1 Orange, microcolony, circular, smooth, flat, moist 99% Bacillus sonorensis - KTT-24 HQ696443.1 Firmicutes ------
Bac119 BS/R 1 Light pink, microcolony, circular, smooth, flat, moist 99% Bacillus sonorensis - R23 JN700092.1 Firmicutes + - - 2.5 - 1 -
Bac120 BS/R 1 white, circular, smooth, convex, moist 98%Oceanicaulis sp. JN501387.1 Protobacteria ------
Bac121 BS/R 5 creamy, circular ,smooth , flat, , moist 99% Virgibacillus olivae HM179177.1 Firmicutes ------
Bac122 BS/R 5 Clear Peach, circular, smooth, convex, moist 99% Bacillus infantis KC184157.1 Firmicutes ------Bac123 BS/R 3 Orange, circular, smooth, convex 99% Bacillus licheniformis EU870503.1 Firmicutes 83% non-ribosomal synthetase [Bacillus + - - - - - licheniformis] WP_025805844.1
Bac127 BS/R 1 Pink, rough, flat, moist, circular, convex, dry 99% Bacillus sonorensis HQ696443.1 Firmicutes ------
Bac128 BS/R 2 Peach,circular,smooth,convex, microcolony, moist 99% Pontibacter korlensis AB682651.1 Bacteroidetes ------
Bac129 BS/R 2 Yellow, microcolony, circular, smooth, convex, moist 99% Pontibacter korlensis NR_044004.1 Bacteroidetes + - - 1 - - -
Bac130 BS/R 2 Orange, circular, smooth, convex, microcolony, moist 99% Pontibacter korlensis NR_044004.1 Bacteroidetes ------
Bac131 BS/R 4 Peach,circular,smooth,convex, moist 98% Planctomycete sp. JF443792.1 Planctomycetes ------
Bac132 BS/R 3 Clear, microcolony, smooth , flat, circular, moist 99% Bacillus infantis JF411305.1 Firmicutes ------
Bac133 BS/R 3 Pech, circular, flat, smooth, moist 99% Bacillus infantis JF411305.1 Firmicutes + ------
Bac134 BS/R 3 creamy,circular, smooth, flat, moist 99% Bacillus niacini EU221359.1 Firmicutes ------
Bac135 BS/R 3 creamy, micocolony, smooth , flat, circular, moist 99% Bacillus odysseyi NR_025258.1 Firmicutes ------
Bac139 BS/R 2 creamy, flat, rough, dry , circular 99% Bacillus sonorensis HQ696443.1 Firmicutes - - - 1 - - -
Bac140 BS/R 2 Yellow, circular,smooth, convex, moist 97% Flavobacteriaceae bacterium GQ246641.1 Bacteroidetes ------
Bac142 BS/R 5 Pink,rough, flat, irrgular, 99% Bacillus sonorensis JN700092.1 Firmicutes ------
Bac143 BS/R 5 creamy, micocolony, smooth , convex, circular, moist 99% Oceanobacillus picturae HM179167.1 Firmicutes ------
Bac144 BS/R 5 Beige,micocolony, smooth ,irrgular 99% Bacillus aquimaris GQ927174.1 Firmicutes - - - 3 - 4 3
Bac145 BS/R 5 Clear, smooth , flat, moist, circular 99% Terribacillus aidingensis GQ304894.1 Firmicutes ------
Bac147 BS/R 5 Clear creamy, micocolony, smooth , flat, moist 99% Bacillus aquimaris GQ927174.1 Firmicutes ------
Bac151 BS/R 1 Yellow, circular,smooth, convex, moist 99% Pseudoalteromonas viridis EU240534.1 Proteobacteria ------
Bac155 BS/R 1 white, circular, smooth, flat, moist 99% Labrenzia marina HQ908720.1 Proteobacteria ------
Bac156 BS/R 2 white, microcolony, circular, smooth, flat, moist 99% Vibrio coralliilyticus HF549288.1 Proteobacteria + + - - - - -
Bac162 BS/R 5 Creamy, micocolony, smooth , convex, circular, moist 99% Vibrio harveyi HQ449971.1 Proteobacteria + ------
Bac163 BS/R 5 Clear Peach, filamentous, smooth, convex 99% Paenibacillus polymyxa HQ538845.1 Firmicutes ------Bac164 BS/R 5 Clear Peach, filamentous, smooth, convex 99% Paenibacillus polymyxa HQ538845.1 Firmicutes 98% non-ribosomal peptide synthetase FusAA [Paenibacillus + - - - - - polymyxa M1] WP_043921404.1 Bac165 BS/R 2 white, microcolony, smooth, flat, moist 99% Brevibacillus formosus AF378234.1 Firmicutes ------
Bac166 BS/R 5 Pink, rhizod, rough, convex, 99% Bacillus licheniformis AY842871.1 Firmicutes + + - - - - -
Bac167 BS/R 3 white, circular, smooth, flat, moist 99% Bacillus licheniformis JF496512.1 Firmicutes + ------
Bac168 BS/R 3 Beige, smooth , flat, circular 99% Bacillus licheniformis KC342874.1 Firmicutes + + - - - - -
Bac171 BS/R 2 white, circular, smooth, flat, moist 99% Brevibacillus formosus NR_040979.1 Firmicutes + + - - - - -
Bac173 MN/K 1 creamy, circular, smooth, convex, moist 99%Vibrio parahaemolyticus JN188420.1 Proteobacteria _ ------
Bac174 MN/K 1 Orange, circular, smooth, convex, moist 99% Pseudoalteromonas piscicida AB681918.1 Proteobacteria 98% adenylation domain of 99% hypothetical nonribosomal peptide protein synthetases [Pseudoalteromonas + - - - - [Pseudoalteromonas piscicida] piscicida]WP_04596517 WP_045965173.1 5.1
Bac175 MN/K 4 Black,circular, smooth, convex, moist 98% Blastopirellula cremea NR_118153.1 Planctomycetes - + - - - - -
Bac176 MN/K 4 creamy, circular, smooth, convex, moist 99% Blastopirellula cremea NR_118153.1 Planctomycetes ------
Bac177 MN/K 2 Light Yellow, microcolony, smooth, flat, moist 99% Microbulbifer salipaludis NR_025232.1 Proteobacteria - - - 3.3 6.5 1 3.8
Bac178 MN/K 2 white, circular, smooth, convex, moist 99% Pseudoalteromonas ruthenica AJ874345.1 Proteobacteria ------
Bac179 MN/K 2 Yellow, circular, smooth, convex, moist 99% Pseudoalteromonas piscicida AB681918.1 Proteobacteria ------Bac180 MN/K 2 white, circular, smooth, convex, moist 99% Vibrio azureus JN128263.1 Proteobacteria 91% hypothetical protein [Vibrio + + - - - - alginolyticus]WP_04710 4361.1 Bac181 MN/K 3 white, circular, smooth, flat, moist 91% Brevibacterium avium KM186615.1 Actinobacteria - + + - - - -
Bac183 MN/K 3 Ceamy, circular, smooth, flat, moist 99% Bacillus pumilus HM585064.1 Firmicutes + ------
Bac184 MN/K 3 white, circular, smooth, flat, moist 99% Bacillus licheniformis EU870503.1 Firmicutes - + - - - - -
Bac185 MN/K 2 Yellow, circular, smooth, convex, moist 99% Pseudoalteromonas piscicida AB681918.1 Proteobacteria + + + - - - -
Bac186 MN/K 2 white, circular, smooth, flat, moist 99% Pseudoalteromonas ruthenica FJ876420.1 Proteobacteria ------
Bac189 MN/K 5 Pink, irrgular, rough, moist 99% Bacillus subtilis KC456632.1 Firmicutes - - - 5.5 2 - -
Bac190 MN/K 5 white, circular, smooth, flat, moist 99% Bacillus pumilus HM585064.1 Firmicutes ------
Bac192 MN/K 2 white, circular, smooth, flat, microcolony, moist 99% Pseudoalteromonas ruthenica FJ876420.1 Proteobacteria ------
Bac193 MN/K 2 white, circular, smooth, convex, moist 99% Stappia aggregata D88520.1 Proteobacteria ------
Bac194 MN/K 2 Yellow, circular, smooth, convex, moist 99% Pseudoalteromonas piscicida AB681918.1 Proteobacteria + + - - - - -
Bac197 MN/K 2 Yellow, circular, smooth, flat, moist 99% Microbulbifer salipaludis NR_025232.1 Proteobacteria - + - - - - -
Bac198 MN/K 1 Yellow, circular, smooth, convex, moist 99% Microbulbifer salipaludis NR_025232.1 Proteobacteria ------
Bac200 MN/K 5 Creamy, circular, smooth, flat, moist 99% Vibrio alginolyticus JN188412.1 Proteobacteria - + + - - - -
Bac201 MN/K 5 Clear, flat, smooth, moist, circular, convex 99% Vibrio alginolyticus JN188406.1 Proteobacteria + + + - - - -
Bac202 MN/K 1 Clear Pink, smooth, flat, moist, circular, convex 99% Vibrio alginolyticus KC210815.1 Proteobacteria + + + - - - -
Bac203 MN/K 1 Yellow, circular, smooth, convex, moist 99% Vibrio alginolyticus JN188406.1 Proteobacteria + - + - - - -
Bac204 MN/K 1 creamy, circular, smooth, flat, moist 99% Vibrio parahaemolyticus KC210810.1 Proteobacteria - - + - - - -
Bac207 MN/K 3 white, circular, smooth, flat, moist 99% Bacillus pumilus HM585064.1 Firmicutes - - - 5 - 1 3.75
Bac208 MN/K 3 creamy, circular, smooth, flat, moist 99% Bacillus pumilus HM585064.1 Firmicutes + - + - - - -
Bac209 MN/K 5 Clear Peach, smooth, flat, moist 99% Bacillus pumilus HM585064.1 Firmicutes ------Bac210 MN/K 5 Pink, flat, wrinkled, rough, irregular 99% Virgibacillus olivae HM179177.1 Firmicutes + - - - - -
Bac213 MM/K 5 Orange, circular, flat, moist 99% Bacillus infantis JF411305.1 Firmicutes - + - - - - -
Bac214 MM/K 5 Clear, flat, viscous, irregular 99% Bacillus pumilus HM585064.1 Firmicutes ------
Bac216 MM/K 2 Yellow, circular, smooth, convex, moist 97% Marinobacter xestospongiae NR_109066.1 Proteobacteria + - + - - - -
Bac217 MM/K 2 creamy, circular, smooth, convex, moist 99% Salinivibrio costicola AB617566.1 Proteobacteria ------
Bac218 MM/K 5 creamy, flat, large colony, smooth, moist 99% Bacillus pumilus HM585064.1 Firmicutes - - - 6 - 2 -
Bac219 MM/K 5 Orange flat, large colony, smooth 99% Bacillus infantis JF411305.1 Firmicutes - + - - - - -
Bac220 MM/K 3 creamy, rhizoid, rough, flat, 99% Bacillus licheniformis EU870503.1 Firmicutes ------
Bac231 MM/K 1 Orange, circular, smooth, convex, moist 99% Pseudoalteromonas piscicida AB681918.1 Proteobacteria ------
Bac241 BS/K 1 creamy, circular, smooth, flat, moist 99% Salinibacillus aidingensis NR_042839.1 Firmicutes ------
Bac242 BS/K 1 Creamy, circular, smooth, flat, moist 99% Bacillus niabensis JF496450.1 Firmicutes ------
Bac243 BS/K 1 Peach, circular, smooth, convex, moist 99% Bacillus aquimaris EU624426.1 Firmicutes - + - - - - -
Bac244 BS/K 1 creamy, circular, smooth, convex, moist 99% Bacillus firmus GQ903383.1 Firmicutes + ------
Bac245 BS/K 2 Green, microcolony, circular, flat, smooth, moist 99% Bacillus sonorensis JN700092.1 Firmicutes 67% non-ribosomal 89% hypothetical 78% hypothetical peptide synthetase protein [Bacillus protein [Bacillus - - - - thuringiensis] [Bacteria]gi|WP_00091 mannanilyticus]WP_051 KKB27200.1 9062.1 541401.1
Bac246 BS/K 2 white, smooth, flat, lage colony, circular 99% Bacillus circulans KC494330.1 Firmicutes ------
Bac247 BS/K 3 light Pink, stick on media, rough, circular 99% Bacillus sonorensis HQ696443.1 Firmicutes - + - 2 - 1 -
Bac248 BS/K 3 light Pink, stick on media, betweem hard and smooth/, 99% Bacillus sonorensis JF411333.1 Firmicutes - + - 1 - 1 - Beige smooth circular convex moist Bac249 BS/K 1 creamy, microcolony, circularn convex, smooth, moist 99% Ornithinibacillus bavariensis GQ903470.1 Firmicutes ------
Bac250 BS/K 1 Pink, Irrgular, flat, wrinkle, , moist 99% Bacillus sonorensis HQ696443.1 Firmicutes - - - 4.2 - - 1.5
Bac251 BS/K 2 white, smooth, circular, convex, moist 99% Bacillus sonorensis KP165033.1 Firmicutes - + - - - - -
Bac252 BS/K 2 Beige, smooth, circular, convex, moist 99% Bacillus sonorensis HQ696443.1 Firmicutes - + - - - - -
Bac253 BS/K 2 white, wrinkled, flat, large media 99% Bacillus sonorensis HQ696443.1 Firmicutes - + - - - 1 3.5
Bac254 MN/K 5 Peach, rhizoid, rough, convex 99% Bacillus subtilis JN366715.1 Firmicutes + + + 5 3 0.5 2.5
Bac255 MN/K 5 white, circular, smooth, flat, moist 99% Enterococcus canintestini GQ337018.1 Firmicutes + ------
Bac256 MN/K 5 Peach, smooth, flat, large colony 99% Bacillus subtilis KC405629.1 Firmicutes + - + 1 - 5 -
Bac257 MN/K 1 Peach, smooth, flat,large media 99% Vibrio azureus JX867736.1 Proteobacteria + + + - - - -
Bac258 MN/K 1 white, circular, smooth, flat, moist 99% Vibrio natriegens FJ171336.1 Proteobacteria + + + - - - -
Bac260 MN/K 1 Brown, microcolony, smooth, flat, moist 99% Ruegeria mobilis HQ338127.1 Proteobacteria ------
Bac261 MN/K 2 Brown, microcolony, smooth, flat, circular, moist 99% Microbulbifer maritimus NR_025772.1 Proteobacteria + ------
Bac262 MN/K 2 white, microcolony, smooth, flat, circular, moist 99% Bacillus firmus GQ903383.1 Firmicutes ------Bac265 MM/K 3 Pink circular rough, flat, moist 99% Bacillus licheniformis GU323366.1 Firmicutes 59% nonribosomal peptide synthetase subunit [Paenibacillus + - - - - - alvei DSM 29] EJW17732.1
Bac266 MM/K 3 Clear white, smooth, convex, circular, moist 99% Bacillus licheniformis JN409457.1 Firmicutes 92% non- ribosomal peptidesynthetase [Bacillus licheniformis] + - - - - - KJH62268.1
Bac267 MM/K 5 Peach, smooth, convex, moist, circular 99% Salinivibrio costicola AB617566.1 Proteobacteria + - - 4 - - 1.5
Bac268 MM/K 5 Clear, flat, media, large colony, smooth 99% Bacillus circulansi JN409450.1 Firmicutes + - - - 4.8 2 1 Bac269 MM/K 5 Peach, flat, media, large colony, smooth 99% Salinivibrio costicola JX913853.1 Proteobacteria - - - - 1.8 6.3 1
Bac270 MM/K 2 white, circular, smooth, convex, moist 99% Aneurinibacillus migulanus AB680889.1 Firmicutes - - - 4 2 3.25 3.5
Bac271 MM/K 2 Orange, microcolony, circular, smooth, moist 99% Aneurinibacillus migulanus AB680889.1 Firmicutes - - - 5.5 3 4.5 3.5
Bac272 MM/K 1 creamy, circular, rough, stick on media media 99% Marinobacter mobilis NR_044456.1 Proteobacteria + ------
Bac273 MM/K 1 Clear, large colony, smooth, moist 99% Salinivibrio costicola JX913853.1 Proteobacteria + ------
Bac274 BS/K 2 white, circular, flat, smooth, microcolny, moist 99% Fulvivirga kasyanovii AB682457.1 Bacteroidetes + - + - - - -
Bac275 BS/K 2 white, circular, flat, smooth, microcolny, moist 99% Bacillus benzoevorans AY043085.1 Firmicutes ------Bac277 BS/K 3 white, circular, flat, smooth, microcolny, moist 99% Bacillus sonorensis JN700094.1 Firmicutes 81% non-ribosomal peptide synthase + + - - - - [Bacillus licheniformis] AJO61325.1
Bac278 BS/K 3 Pink, circular, smooth, convex, moist 99% Bacillus subtilis JQ973708.1 Firmicutes + _ + 1 5 - -
Bac279 BS/K 1 white, circular, smooth, convex, moist 99% Virgibacillus pantothenticus JN791392.1 Firmicutes ------
Bac280 BS/K 1 Beige, circular, smooth, convex, moist 99% Sporosarcina koreensis KC355330.1 Firmicutes ------
Bac282 BS/K 5 Clear, filamitous, smooth, conex , moist 99% Bacillus sonorensis HQ696443.1 Firmicutes + + - - - - -
Bac283 BS/K 5 Pink, rough, rhizoid, convex 99% Bacillus sonorensis JN700094.1 Firmicutes + + - - - - -
Bac284 BS/K 3 white, circular, flat, stick on media 99% Bacillus sonorensis JN700094.1 Firmicutes - + - - - - -
Bac287 BS/K 2 white, microcolony, smooth, flat, circular, moist 99% Pseudoalteromonas hodoensis NR_126232.1 Proteobacteria ------
Bac288 BS/K 2 white, microcolony, smooth, flat, circular, moist 93%Pseudoalteromonas atlantica KP645203.1 Proteobacteria + + - - - - -
Bac289 BS/K 5 Pink, irrgular, large colony, rough 99% Bacillus halodenitrificans. AY543168.1 Firmicutes ------
Bac291 BS/K 2 Pink, flat,large colony, wrinkled 99% Pseudoalteromonas atlantica KP645203.1 Proteobacteria 70 % nonribosomal peptide synthase [Burkholderia + - 1.5 - - - pseudomallei] WP_044368416.1
Bac292 BS/K 2 creamy, microcolony, circular, smooth, convex, moist 99% Pseudoalteromonas espejiana. KC178899.1 Proteobacteria ------
Bac295 BS/K 5 white, circular, smooth, flat, moist 99% Bacillus niabensis JF496450.1 Firmicutes - + - - - - -
Bac296 BS/K 5 pink, circular, smooth, convex, moist 99% Bacillus halodenitrificans AY543168.1 Firmicutes ------
Bac298 MM/K 5 creamy,circular, smooth, convex, moist 99% Bacillus pumilus JF496399.1 Firmicutes ------
Bac299 MM/K 5 Orange, circular, smooth, convex, moist 99% Virgibacillus salarius NR_041270.1 Firmicutes ------
Bac301 MM/K 1 creamy, circular, smooth, flat, moist 99% Pseudoalteromonas sp. JX075059.1 Proteobacteria ------
Bac302 MM/K 2 creamy, rhizod, flat, rough, moist 99% Pseudoalteromonas sp. JX045665.1 Proteobacteria - + - - - - -
Bac306 MN/K 1 creamy , circular, smooth convex, moist 99% Pseudoalteromonas piscicida AB681918.1 Proteobacteria - + - - - - -
Bac318 MM/R 1 creamy, flat, smooth, moist, convex, circular 99% Virgibacillus dokdonensis JN903905.1 Firmicutes - - - 3 - 1.9 -
Bac319 MM/R 2 white, circular, smooth, convex, moist 98% Pseudoalteromonas espejiana KC178899.1 Proteobacteria + + + 1 - - -
Bac320 MM/R 5 Clear,Irrgular, flat, microcolony, smooth, moist 98% Pseudoalteromonas atlantica KP645203.1 Proteobacteria - - - 1 - 1 -
Bac323 MN/R 5 white, irrgular, smooth, flat,, moist 99% Bacillus foraminis NR_042274.1 Firmicutes - - + - - - -
Bac324 MN/R 5 Orange, smooth, circular, convex, moist 99% Virgibacillus halodenitrificans NR_042967.1 Firmicutes ------
Bac325 MN/R 5 Orange, smooth, circular, convex, moist 99% Pseudoalteromonas espejiana KC178899.1 Proteobacteria - + - 0.5 - - -
Bac326 MN/R 2 white, irrgular, smooth, flat,, moist 99%Pseudoalteromonas elyakovii DQ517879.1 Proteobacteria + + -
Bac327 MN/R 5 white, circular, smooth, flat 99% Virgibacillus pantothenticus JN791392.1 Firmicutes + - - 1.8 - 6 -
Bac330 MN/R 1 Light Yellow, smooth, circular, convex, moist 99% Virgibacillus dokdonensis JN903905.1 Firmicutes - - - 3 - 2 -
Bac332 MN/R 1 white,circular and from the end rhizod, smooth, flat 99% Virgibacillus pantothenticus JN791392.2 Firmicutes - - - 1.13 - 1 2.8
Bac333 MN/R 1 white, smooth, flat, moist, circular, convex 99% Virgibacillus salarius NR_041270.1 Firmicutes - - + - - - 2 Bac334 BS/R 3 Yellow, circular, smooth, convex, moist 99% Micrococcus luteus EU379288.1 Actinobacteria ------
Bac335 BS/R 3 creamy, circular, smooth, convex, moist 99% Gordonia aichiensis FJ536314.1 Actinobacteria + ------
Bac336 BS/R 1 white, circular, smooth, convex, moist 99% Pseudoalteromonas atlantica KP645203.1 Proteobacteria + + - 2 - 1 -
Bac337 BS/R 1 white, circular, smooth, convex, moist 99% Pseudoalteromonas espejiana JX867735.1 Proteobacteria + + - 2.5 - 1.5 -
Bac338 BS/R 2 white, circular, smooth, convex, moist 99%Pseudoalteromonas hodoensis HM598083.1 Proteobacteria - + - - - - -
Bac342 BS/K 2 white, circular, smooth, convex, moist 99% Pseudoalteromonas atlantica NR_126232.1 Proteobacteria ------
Bac344 BS/R 5 creamy, circular, smooth, convex, moist 99% Staphylococcus epidermidis KC443110.1 Firmicutes - - - 1 - - -
Bac345 BS/R 5 Clear,Irrgular, flat, smooth, moist 99% Bacillus subtilis HM585050.1 Firmicutes - - - 1 - 2 -
Bac351 MN/K 5 Yellow, smooth, flat, moist, circular, moist 99% Pseudoalteromonas piscicida AB681918.1 Proteobacteria - + - - - - -
Bac353 MN/K 3 creamy smooth, flat, circular, moist 99% Ruegeria pelagia AB681677.1 Proteobacteria ------
Bac355 BS/K 5 ight Pink, Irrgular, flat, smooth, moist 99% Bacillus cereus JQ248587.1 Firmicutes - - - 4 - - -
Bac358 BS/K 2 white, microcolony, circular, smooth, convex 99% Bacillus vietnamensis HQ699497.1 Firmicutes + ------
Bac361 BS/K 1 creamy, circular, smooth, convex 99% Ruegeria pelagia AB681677.1 Proteobacteria - - + - - - -
Bac363 MM/K 5 Clear,microcolony, convex, smooth, circular 99% Paenibacillus dendritiformi HM071942.1 Firmicutes 80% non-ribosomal peptide synthetase + + 0.5 3 1 5 [Paenibacillus elgii] WP_050900668.1
Bac366 MM/K 3 creamy, smooth, flat, circular, moist 99% Stenotrophomonas maltophilia JX262392.1 Proteobacteria - - + - - - - Bac369 MM/K 2 white, circular, smooth, convex, moist 99% Pseudoalteromonas nigrifaciens GU726859.1 Proteobacteria 65% nonribosomal peptide synthetase subunit [Paenibacillus + + - - - - alvei DSM 29] EJW20318.1
Bac370 MM/K 1 creamy, smooth, flat, moist, circular 99% Marinobacter mobilis NR_044456.1 Proteobacteria ------
Bac371 MM/K 1 Creamy,circular, smooth, convex, moist 99% Ruegeria pelagia AB681677.1 Proteobacteria ------
Bac372 BS/R 5 Clear, circular, smooth, convex, moist 99% Bacillus methylotrophicus KC405629.1 Firmicutes - - - 1 - 1 -
Bac373 BS/R 5 white, circular, smooth, flat, moist 99% Bacillus cereus KC178715.1 Firmicute ------
Bac374 BS/R 3 creamy, circular,smooth , convex, moist 99% Pseudomonas syncyanea JX192650.1 Proteobacteria ------
Bac375 BS/R 3 creamy, circular,smooth , flat 99% Pseudomonas fluorescens HQ420253.1 Proteobacteria - - - 3 - - -
Bac376 BS/R 1 creamy, circular,smooth, convex 99% Virgibacillus olivae HM179177.1 Firmicutes + - - - - 7 -
Bac378 BS/R 2 Clear, circular, smooth, convex 99% Ruegeria pelagia AB681677.1 Proteobacteria ------
Bac380 MN/R 3 white, circular, smooth, convex 99% Stenotrophomonas maltophilia JX262392.1 Proteobacteria - - - 5 - - -
Bac381 MM/R 5 ight Pink, circular, convex, smooth, moist 99% Bacillus cereus JN934390.1 Firmicutes ------
Bac383 MM/R 1 creamy, smooth, flat , circular, moist 99% Pseudoalteromonas ruthenica NR_025140.1 Proteobacteria ------2
Bac384 MM/R 1 creamy, circular, convex, smooth , moist 99% Pseudoalteromonas ruthenica NR_025140.1 Proteobacteria ------
Bac385 MM/R 3 white, circular, smooth, convex, moist 99% Bacillus subtilis FJ959367.1 Firmicutes + ------
Bac386 MM/R 3 white, microcolony, circular, smooth, convex, moist 99% Bacillus cereus KC248212.1 Firmicutes ------
Bac387 MN/R 1 creamy, flat, smooth, moist, circular 96% Exiguobacterium profundum JX112643.1 Firmicutes 83% non-ribosomal 53% hypothetical peptide synthase protein [Psychrobacter - - - - - [Bacillus licheniformis] sp. JCM 18902] AJO61326.1 WP_045445323.1
Bac389 MN/R 5 ight Pink, circular, convex, smooth, moist 99% Bacillus cereus JF895490.1 Firmicutes + - + - - - 0.5 Bac390 MN/R 5 ight Pink, circular, convex, smooth, moist 99% Paenibacillus dendritiformis JX499920.1 Firmicutes 80% non-ribosomal 86% hypothetical peptide synthetase protein [Bacillus [Paenibacillus thuringiensis] + 2 2 5 3 polymyxa] gi|803756437|KKB2720 WP_050900668.1 0.1 Bac391 MN/R 2 creamy, microcolony ,circular, convex, smooth, moist 99% Exiguobacterium arabatum JX913842.1 Firmicutes ------
Bac393 MN/R 3 white, irrgular, convex, smooth 99% Bacillus cereus HQ143564.1 Firmicutes ------1
Bac394 MN/R 3 white, circular, smooth, convex, moist 99% Bacillus cereus HQ143564.1 Firmicutes - - - - - 2 -
Bac395 MN/R 3 white, circular, smooth, convex, moist 99% Stenotrophomonas maltophilia JX262392.1 Proteobacteria + - + - - - -
Bac396 MN/R 3 white, circular, smooth, convex, moist 99% Stenotrophomonas maltophilia JX262392.1 Proteobacteria ------Abbreviation
MN Mangrove Mud MM Microbial Mat BS Bareen Soil K Al-Kharrar R Rabigh
Media Name NO.
Difco Marine Agar 2216 (MA) 1
10% Difco Marine Agar 2216 (10% MA) 2 Actinomyces Isolation Agar (AIA) 3 Difco Marine Agar 2216 with 1g/L streptomycin (Anti- MA) 4 Difco Marine Broth 2216 Gellan gum (MA-GM) 5 Table S5.2. NRPS and PKS results of strains that exhibited antimicrobial activity. Type of PKS/NRPS Zone of Inhibition (mm) Sample ID Location Closest Relative by BLAST samples NRPS PKSI PKSII Staphylococcus Salmonella Pseudomonas Escherichia coli Annular Annular Annular Annular Diameter Diameter Diameter Diameter radius radius radius radius Bac4 MN RHL 99% Bacillus licheniformis + + - 1 7 ------Bac5 MN RHL 99% Bacillus licheniformis + - - 0.5 6 - - 2.5 10 1 6.7 Bac57 MN RHL 99% Bacillus amyloliquefaciens ------5 15 - - Bac75 MM RHL 99% Virgibacillus dokdonensis - - - 1 7 - - 1 7 - - 95% non-ribosomal 74% hypothetical peptide synthetase protein [Bacillus Bac84 MM RHL 99% Bacillus licheniformis [Bacillus sp. + 4.5 14 3 11 3 11 3 10.8 subtilis] MSP5.4] WP_015252614.1 WP_039073180.1 Bac90 MM RHL 99% Bacillus sonorensis - - - 3.75 9.5 2.7 10 3 11 3 10.7 Bac98 MM RHL 99% Brevibacillus borstelensis - - - 5 15 0.5 6 4.2 13 4 12.8 99%hypothetical 78% non-ribosomal 89% hypothetical protein peptide synthetase protein [Bacillus Bac111 MM RHL 99% Bacillus vallismortis [Paenibacillus 2 9 4 13 0.5 6 5 15 [Paenibacillus elgii] thuringiensis] dendritiformis] WP_050900668.1 KKB27200.1 WP_006677536 Bac119 BS RHL 99% Bacillus sonorensis - R23 + - - 2.5 10 - - 1 7 - - Bac129 BS RHL 99% Pontibacter korlensis + - - 1 7 ------Bac139 BS RHL 99% Bacillus sonorensis - - - 1 7 ------Bac144 BS RHL 99% Bacillus aquimaris - - - 3 11 - - 4 13 3 10.8 Bac177 MN AKL 99% Microbulbifer salipaludis - - - 3.3 11 6.5 18 1 7 3.8 12.4 Bac189 MN AKL 99% Bacillus subtilis - - - 5.5 16 2 9 - - - - Bac207 MN AKL 99% Bacillus pumilus - - - 5 15 - - 1 7 3.7 12.2 Bac218 MM AKL 99% Bacillus pumilus - - - 6 17 - - 2 9 - - Bac247 BS AKL 99% Bacillus sonorensis - + - 2 9 - - 1 7 - - Bac248 BS AKL 99% Bacillus sonorensis - + - 1 7 - - 1 7 - - Bac250 BS AKL 99% Bacillus sonorensis - - - 4.2 13 - - - 1.5 7.8 Bac253 BS AKL 99% Bacillus sonorensis - + - - - - - 1 7 3.5 12 88% nonribosomal 89% hypothetical 78% hypothetical peptide synthase protein [Bacillus protein Bac254 MN AKL 99% Bacillus subtilis 5 15 3 11 0.5 6 2.5 10 [Paenibacillus alvei] thuringiensis] [Bacteria]gi|WP_00 WP_021255906.1 KKB27200.1 0919062.1 Bac256 MN AKL 99% Bacillus subtilis + - + 1 7 - - 5 15 - - Bac267 MM AKL 99% Salinivibrio costicola + - - 4 13 - - - - 1.5 7.7 Bac268 MM AKL 99% Bacillus circulansi + - - - - 4.8 14 2 9 1 5.6 Bac269 MM AKL 99% Salinivibrio costicola - - - - - 1.8 8 6.3 17 1 5.7 Bac270 MM AKL 99% Aneurinibacillus migulanus - - - 4 13 2 9 3.2 11 3.5 12 Bac271 MM AKL 99% Aneurinibacillus migulanus - - - 5.5 16 3 11 4.5 14 3.5 11.7 Bac278 BS AKL 99% Bacillus subtili s + _ + 1 7 5 15 - - - - 70 % nonribosomal peptide synthase Bac291 BS AKL 99% Pseudoalteromonas atlantica[Burkholderia + - 1.5 7.5 ------pseudomallei] WP_044368416.1 Bac318 MM RHL 99% Virgibacillus dokdonensis - - - 3 11 - - 1.9 8.5 - - Bac319 MM RHL 98% Pseudoalteromonas espejian+ + + 1 7 ------Bac320 MM RHL 98% Pseudoalteromonas atlantic- - - 1 7 - - 1 7 - - Bac325 MN RHL 99% Pseudoalteromonas espejian- + - 0.5 6 ------Bac327 MN RHL 99% Virgibacillus pantothenticus + - - 1.8 - - 6 16 - - Bac330 MN RHL 99% Virgibacillus dokdonensis - - - 3 11 - - 2 9 - - Bac332 MN RHL 99% Virgibacillus pantothenticus- - - 1.13 6 - - 1 7 2.8 10.4 Bac333 MN RHL 99% Virgibacillus salarius - - + ------2 9 Bac336 BS RHL 99% Pseudoalteromonas atlantica+ + - 2 9 - - 1 7 - - Bac337 BS RHL 99% Pseudoalteromonas espejian+ + - 2.5 10 - - 1.5 8 - - Bac344 BS RHL 99% Staphylococcus epidermidis - - - 1 7 ------Bac345 BS RHL 99% Bacillus subtilis - - - 1 7 - - 2 9 - - Bac355 BS RHL 99% Bacillus cereus - - - 4 13 ------80% non-ribosomal peptide synthetase Bac363 MM AKL 99% Paenibacillus dendritiformis + + 0.5 6 3 11 1 7 5 15 [Paenibacillus elgii] WP_050900668.1 Bac372 BS RHL 99% Bacillus methylotrophicus - - - 1 7 - - 1 7 - - Bac375 BS RHL 99% Pseudomonas fluorescens - - - 3 11 ------Bac376 BS RHL 99% Virgibacillus olivae + ------7 18 - - Bac380 MN RHL 99% Stenotrophomonas maltophil- - - 5 15 ------Bac383 MM RHL 99% Pseudoalteromonas ruthenic------2 9 Bac389 MN RHL 99% Bacillus cereus + - + ------0.5 6 80% non-ribosomal 86% hypothetical peptide synthetase protein [Bacillus Bac390 MN RHL 99% Paenibacillus dendritiformis [Paenibacillus thuringiensis] + 2 9 2 9 5 15 3 11 polymyxa] gi|803756437|KKB WP_050900668.1 27200.1 Bac393 MN RHL 99% Bacillus cereus ------1 6.5 Bac394 MN RHL 99% Bacillus cereus ------2 9 - 0 Table S5.2: Genus abundance
Genus BS/K BS/R MN/K MN/R MM/K MM/R Total number of different species 8 18 10 11 8 12 Arnithinibacillus 1 0 0 0 2 0 Bacillus 22 21 10 18 9 17 Blastopirellula 0 0 2 0 0 2 Brevibacillus 0 2 1 0 0 3 Enterococcus 0 0 1 0 0 0 Exiguobacterium 0 0 0 2 0 0 Flavobacteriaeae 0 1 0 0 0 0 Fulvivirga 1 0 0 0 0 0 Gordonia 0 1 0 2 0 0 Isopteriola 0 0 0 1 0 0 Labrenzia 0 1 0 0 0 0 Marinobacter 0 0 0 0 3 1 Microbulbifer 0 0 4 7 0 1 Micrococcus 0 1 0 0 0 0 Oceanicaulis 0 1 0 0 0 0 Oceanobacillus 0 1 0 0 0 0 Paenibacillus 0 2 0 1 1 0 Planctomycete 0 1 0 0 0 1 Pontibacter 0 3 0 0 0 0 Pseudoalteromonas 5 4 9 2 4 7 Psudomonas 0 2 0 0 0 0 Psychrobacter 0 0 0 0 0 4 Ruegeria 1 1 2 0 1 0 Saccharosirillum 0 0 0 0 0 1 Salinibacillus 1 0 0 0 0 0 Salinivibrio 0 0 0 0 4 3 Sporosarcina 1 0 0 0 0 0 Staphylococcus 0 1 0 0 0 0 Stappia 0 0 1 0 0 0 Stenotrophomonas 0 0 0 3 0 0 Terribacillus 0 1 0 0 0 0 vibrio 0 2 9 14 0 1 Virgibacillus 1 2 1 8 1 5