Karanj (Pongamia Pinnata) – an Ayurvedic and Modern Overview
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Karanja” Belonging to Family Leguminosae
Int. J. Pharm. Sci. Rev. Res., 59(1), November - December 2019; Article No. 05, Pages: 22-29 ISSN 0976 – 044X Review Article The Review: Phytochemical and Bioactive Screening of “Karanja” belonging to family Leguminosae. Preethima G1*, Ananda V 1, D. Visagaperumal 1, Vineeth Chandy 1, Prashanthi P 2 1Department of Pharmaceutical chemistry, T. John College of Pharmacy, Bangalore, India. 2Department of Pharmacognosy, T. John College of Pharmacy, Bangalore, Karnataka, India. *Corresponding author’s E-mail: [email protected] Received: 10-09-2019; Revised: 22-10-2019; Accepted: 03-11-2019. ABSTRACT Traditional medicine consists of huge number of plants with different pharmacological and medicinal values. The bioactive molecules have been identified. Pongamia pinnata (Linn.) Pierre is one of the oldest plants with numerous properties, which is found all over the globe. It is commonly known as “Indian beech tree” and has been identified in Ayurvedic and Siddha system of medicines for the healing effect of human beings. Different parts of whole plant are used for treatment of various diseases including rheumatism, diarrhoea, gonorrhoea, whooping cough, leprosy and bronchitis. Extracts of the whole plant show significant anti- plasmodial, anti-ulcerogenic, anti-diarrhoeal, anti-inflammatory, anti-fungal, and analgesic activities. Its oil is used as a source of biodiesel. The present review paper was aimed to u0pdate the information of Pongamia pinnata with reference to its pharmacological properties, chemical constituents and its use as anti-urolithiatic agent for the treatment of Urolithiasis. Keywords: Pongamia pinata, Indian beech tree, Healing effect, Anti-urolithiatic agent, urolithiasis. INTRODUCTION four- to five-toothed, with a papilionaceous corolla. -
The Pongam Tree, Unfit for Florida Landscaping, Has Multiple Practical Uses in Under-Developed Lands
Proc. Fla. State Hort. Soc. 103:338-343. 1990. THE PONGAM TREE, UNFIT FOR FLORIDA LANDSCAPING, HAS MULTIPLE PRACTICAL USES IN UNDER-DEVELOPED LANDS Julia F. Morton come 6 to 14 in long; have 3 to 9 opposite, elliptic or obo- Morton Collectanea vate leaflets, 2 to 6 in long, pointed at the apex, dark- University of Miami green, glossy on the upper surface, paler, dull, with prom Coral Gables, FL 33124 inent veins on the underside. The strongly fragrant, pea- like flowers, V2 in long, may be white, pale-pink, or laven Additional index words. Pongamia pinnata, P. glabra, Derris der with purple calyx; are borne in axillary racemes to 10 indica. in long. The short-stalked pods, borne in great abundance 3 to 4 months after blooming, are somewhat almond- Abstract. The pong am tree, Pongamia pinnata (Linn.) Merr. (P. shaped, with a short, recurved beak at the apex. They are glabra Vent, nom Meg.) (7), grows wild on seashores and about lA in thick, II/2 to 2V2 in long, V4 to 1 V2 in wide; along inland waterways from India and Malaysia to northern bright-green and waxy when immature; light-brown when Australia, the Philippines and Polynesia. It was introduced mature and dry; leathery and durable; remain on the tree into Hawaii by Hillebrand in the 1860#s. The U.S. Department all year, are difficult to crush on the ground, creating a of Agriculture received seeds from Sri Lanka in 1910, from long-lasting litter. In the words of Cowen (26): "The Mauritius in 1911, from India in 1912, from Egypt in 1916, ground below is always covered with a crackling carpet." and from India in 1926. -
UHPLC-MS Chemical Fingerprinting and Antioxidant, Antiproliferative, and Enzyme Inhibition Potential of Gaultheria Pumila Berries
H OH metabolites OH Article UHPLC-MS Chemical Fingerprinting and Antioxidant, Antiproliferative, and Enzyme Inhibition Potential of Gaultheria pumila Berries Carlos Fernández-Galleguillos 1, Luisa Quesada-Romero 2,*, Adrián Puerta 3, José M. Padrón 3 , Ernane Souza 4, Javier Romero-Parra 5 and Mario J. Simirgiotis 1,6,* 1 Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Campus Isla Teja, Valdivia 5090000, Chile; [email protected] 2 Facultad de Ciencias Para el Cuidado de la Salud, Universidad San Sebastián, Valdivia 5090000, Chile 3 BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, 38206 La Laguna, Spain; [email protected] (A.P.); [email protected] (J.M.P.) 4 The Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL 33401, USA; [email protected] 5 Departamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Olivos 1007, Casilla 233, Santiago 6640022, Chile; [email protected] 6 Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia 5090000, Chile * Correspondence: [email protected] (L.Q.-R.); [email protected] (M.J.S.); Tel.: +56-632632811 (L.Q.-R.) Citation: Fernández-Galleguillos, C.; Quesada-Romero, L.; Puerta, A.; Abstract: Gaultheria pumila (Ericaceae) (known as Chaura or Mutilla) is a Chilean native small Padrón, J.M.; Souza, E.; shrub that produces berry fruits consumed by local Mapuche people. In this study, the chemical Romero-Parra, J.; Simirgiotis, M.J. fingerprinting and antioxidant, enzyme inhibition, and antiproliferative activities of the berries UHPLC-MS Chemical Fingerprinting were investigated for the first time. -
Flavonoids from Lonchocarpus Araripensis (Leguminosae): Identification and Total 1H and 13C Resonance Assignment
American International Journal of Contemporary Research Vol. 4 No. 2; February 2014 Flavonoids from Lonchocarpus araripensis (Leguminosae): Identification and Total 1H and 13C Resonance Assignment Almi F. Lima Daniele A. Ferreira Francisco J. Q. Monte Programa de Pós-Graduação em Química, Departamento de Química Orgânica e Inorgânica Universidade Federal do Ceará 60.021-940 Fortaleza – CE, Brasil Raimundo Braz-Filho Laboratório de Ciências Químicas, Centro de Ciências Tecnológicas, Universidade Estadual do Norte Fluminense 28.013-602 Campos dos Goytacazes – RJ, Brasil Abstract The NMR study of the flavonoids 6a,11a-dihydro-9-methoxy-6H-benzofuran[3,2-C] benzopiran-3-ol (1) and (2,3- ” ” cis-3,4-cis-3,4,5,8-tetramethoxy-[1 ,2 : 6,7]-furanoflavan (2) is described. In addition to convencional 1D NMR methods, 2D shift-correlated NMR techniques (COSY, HMQC, HMBC and NOESY) were used for the complete 1H and 13C resonance assignments. The relative stereochemistry at the asymmetric centers was established by nOe difference experiments. The compounds 1 and 2 are novel to Lonchocarpus araripensis. Keywords: Lonchocarpus araripensis, Leguminosae, flavonoids, 1H and 13C NMR, 2D NMR, nOe difference spectra 1.0 Introduction The genus Lonchocarpus (Leguminosae) is found to be rich in phenol compounds, including flavones, chalcones, flavonols, flavans, flavanones, and aurones.(Alvarez-Solano et al., 2000; Borges-Argaez et al., 2002; Lawson et al., 2006; Magalhães et al., 1996; Magalhães et al., 1999; Nascimento et al., 1976). Furan and pyran moieties located at ring A in a linear or angular position, linked to either C-6/C-7 or C-7/C-8, respectively, are a common characteristic of the flavonoids produced by plants of this genus (Alvarez-Solano et al., 2000; Borges-Argaez et al., 2002; Lima et al., 2009; Magalhães et al., 1996; Magalhães et al., 1999; Nascimento et al., 1976; Nascimento and Mors, 1981). -
Medicinal Uses, Phytochemistry and Pharmacology of Pongamia Pinnata (L.) Pierre: a Review
Journal of Ethnopharmacology 150 (2013) 395–420 Contents lists available at ScienceDirect Journal of Ethnopharmacology journal homepage: www.elsevier.com/locate/jep Review Medicinal uses, phytochemistry and pharmacology of Pongamia pinnata (L.) Pierre: A review L.M.R. Al Muqarrabun a, N. Ahmat a,n, S.A.S. Ruzaina a, N.H. Ismail a, I. Sahidin b a Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia b Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Haluoleo University (Unhalu), 93232 Kendari, Southeast Sulawesi, Indonesia article info abstract Article history: Ethnopharmacological relevance: Pongamia pinnata (L.) Pierre is one of the many plants with diverse Received 10 April 2013 medicinal properties where all its parts have been used as traditional medicine in the treatment and Received in revised form prevention of several kinds of ailments in many countries such as for treatment of piles, skin diseases, 19 August 2013 and wounds. Accepted 20 August 2013 Aim of this review: This review discusses the current knowledge of traditional uses, phytochemistry, Available online 7 September 2013 biological activities, and toxicity of this species in order to reveal its therapeutic and gaps requiring Keywords: future research opportunities. Pongamia pinnata Material and methods: This review is based on literature study on scientific journals and books from Fabaceae library and electronic sources such as ScienceDirect, PubMed, ACS, etc. Anti-diabetic Results: Several different classes of flavonoid derivatives, such as flavones, flavans, and chalcones, and Anti-inflammatory Karanjin several types of compounds including terpenes, steroid, and fatty acids have been isolated from all parts Pongamol of this plant. -
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Antibacterial
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Antibacterial Chemical Dosage (+)-8HYDROXYCALAMENENE -- (+)-8HYDROXYCALAMENENE -- (+)-GALBACIN -- (+)-T-CADINOL MIC=2-24 ug/ml (-)-EPICATECHIN -- (-)-EPIGALLOCATECHIN -- (-)-EPIGALLOCATECHIN-GALLATE -- (2Z,8Z)-10-ANGELOYLOXY-MATRICARIA-ESTER MIC=50->100 ug/mL (5R,8R,9S,10R)-12-OXO-ENT-3,13-CLERODIEN-15-OIC-ACID 20-25ug/ml (Z)-1,3-BIS(4-HYDROXYPHENYL)-1,4-PENTADIENE -- 1,2,4-TRIHYDROXYHEPTADECA-16-ENE -- 1,2-DIHYDROXY-4-GLUCOSYLNAPTHALENE -- 1,3,4,5-TETRACAFFEOYLQUINIC-ACID -- 1,3,5-TRIMETHOXYBENZENE -- 1,4-NAPTHAQUINONE -- 1,8-CINEOLE 50 ppm 1-ACETYLJATIVATRIOL -- 1-ETHYL-BETA-CARBOLINE -- 1-METHOXYCANTHIN-6-ONE -- 1-TULIPOSIDE-A -- 1-TULIPOSIDE-B -- 15-ALPHA-ACETOXYKAUREN-19-OIC-ACID 250 mM/ml 16-HYDROXYPSEUDOJOLKINOLIDE -- 2,4,6-TRIMETHOXYPHENOL -- 2,6-DIMETHOXY-P-BENZOQUINONE -- 2,7-DIHYDROXYCADALENE -- 2,7-DIMETHOXY-5-ISOPROPYL-3-METHYL-8,1-NAPTHALENE-CARBOLACTONE -- Chemical Dosage 2-HYDROXY-5-ISOPROPYL-7-METHOXY-3-METHYL-8,1-NAPTHALENE-CARBOLACTONE -- 3'-FORMYL-2',4',6'-TRIHYDROXY-5'-METHYLDIHYDROCHALCONE -- 3'-O-METHYLBATATASIN-III -- 3,4-DIHYDROXYBENZOIC-ACID -- 3,4-DIMETHOXYTOLUENE -- 3,4-SECOTRACHYLOBANOIC-ACID MIC=25 ug/ml 3,4-SECOTRITERPENE-ACID-20-EPI-KOETJAPIC-ACID MIC=3->6.25 ug/ml 3,5'-DIALLYL-2'-HYDROXY-4-METHOXYBIPHENYL-ETHER -- 3,5-BIS(3-METHYL-2-BUTENYL)-4-METHOXY-BENZOIC-ACID MIC=1.25->50 nM 3,5-DIMETHOXY-1,6-DIHYDROXYXANTHONE -- 3-CARBOMETHOXY-1,8-DIHYDROXYANTHRAQUINONE -- 3-METHOXY-1,8-DIHYDROXY-ANTHRQUINONE -- 3-O-METHYL-MANGOSTIN -- 3-OXO-11-ALPHA-HYDROXYOLEAN-12-ENE-30-OIC-ACID -
Phenolics and Flavonoids Contents of Medicinal Plants, As Natural Ingredients for Many Therapeutic Purposes- a Review
IOSR Journal Of Pharmacy (e)-ISSN: 2250-3013, (p)-ISSN: 2319-4219 Volume 10, Issue 7 Series. II (July 2020), PP. 42-81 www.iosrphr.org Phenolics and flavonoids contents of medicinal plants, as natural ingredients for many therapeutic purposes- A review Ali Esmail Al-Snafi Department of Pharmacology, College of Medicine, Thi qar University, Iraq. Received 06 July 2020; Accepted 21-July 2020 Abstract: The use of dietary or medicinal plant based natural compounds to disease treatment has become a unique trend in clinical research. Polyphenolic compounds, were classified as flavones, flavanones, catechins and anthocyanins. They were possessed wide range of pharmacological and biochemical effects, such as inhibition of aldose reductase, cycloxygenase, Ca+2 -ATPase, xanthine oxidase, phosphodiesterase, lipoxygenase in addition to their antioxidant, antidiabetic, neuroprotective antimicrobial anti-inflammatory, immunomodullatory, gastroprotective, regulatory role on hormones synthesis and releasing…. etc. The current review was design to discuss the medicinal plants contained phenolics and flavonoids, as natural ingredients for many therapeutic purposes. Keywords: Medicinal plants, phenolics, flavonoids, pharmacology I. INTRODUCTION: Phenolic compounds specially flavonoids are widely distributed in almost all plants. Phenolic exerted antioxidant, anticancer, antidiabetes, cardiovascular effect, anti-inflammatory, protective effects in neurodegenerative disorders and many others therapeutic effects . Flavonoids possess a wide range of pharmacological -
Natural Products As Chemopreventive Agents by Potential Inhibition of the Kinase Domain in Erbb Receptors
Supplementary Materials: Natural Products as Chemopreventive Agents by Potential Inhibition of the Kinase Domain in ErBb Receptors Maria Olivero-Acosta, Wilson Maldonado-Rojas and Jesus Olivero-Verbel Table S1. Protein characterization of human HER Receptor structures downloaded from PDB database. Recept PDB resid Resolut Name Chain Ligand Method or Type Code ues ion Epidermal 1,2,3,4-tetrahydrogen X-ray HER 1 2ITW growth factor A 327 2.88 staurosporine diffraction receptor 2-{2-[4-({5-chloro-6-[3-(trifl Receptor uoromethyl)phenoxy]pyri tyrosine-prot X-ray HER 2 3PP0 A, B 338 din-3-yl}amino)-5h-pyrrolo 2.25 ein kinase diffraction [3,2-d]pyrimidin-5-yl]etho erbb-2 xy}ethanol Receptor tyrosine-prot Phosphoaminophosphonic X-ray HER 3 3LMG A, B 344 2.8 ein kinase acid-adenylate ester diffraction erbb-3 Receptor N-{3-chloro-4-[(3-fluoroben tyrosine-prot zyl)oxy]phenyl}-6-ethylthi X-ray HER 4 2R4B A, B 321 2.4 ein kinase eno[3,2-d]pyrimidin-4-ami diffraction erbb-4 ne Table S2. Results of Multiple Alignment of Sequence Identity (%ID) Performed by SYBYL X-2.0 for Four HER Receptors. Human Her PDB CODE 2ITW 2R4B 3LMG 3PP0 2ITW (HER1) 100.0 80.3 65.9 82.7 2R4B (HER4) 80.3 100 71.7 80.9 3LMG (HER3) 65.9 71.7 100 67.4 3PP0 (HER2) 82.7 80.9 67.4 100 Table S3. Multiple alignment of spatial coordinates for HER receptor pairs (by RMSD) using SYBYL X-2.0. Human Her PDB CODE 2ITW 2R4B 3LMG 3PP0 2ITW (HER1) 0 4.378 4.162 5.682 2R4B (HER4) 4.378 0 2.958 3.31 3LMG (HER3) 4.162 2.958 0 3.656 3PP0 (HER2) 5.682 3.31 3.656 0 Figure S1. -
Factiva RTF Display Format
SE REGIONAL HD Phase I of Handri-Neeva in three years, says YSR BY By Our Staff Reporter WC 479 words PD 21 June 2004 SN The Hindu SC THINDU PG 03 LA English CY (c) 2004 Kasturi & Sons Ltd LP The Chief Minister, Y.S. Rajasekhara Reddy, has announced that the first phase of Handri Neeva Sujala Sravanti (HNSS) irrigation project will be completed in the next three years. About two lakhs acres in Kurnool and Anantapur district will be given water in the first phase, he stated. Addressing an impromptu press conference near Gudibanda in the district today during his Rajiv Pallebata visit he stated that the project cost had now escalated to Rs. 3,000 crores. The first phase would be completed with Rs. 1,300 crores. TD Asked about the availability of water to the project the Chief Minister said there was no way but diversion of Godavari waters to the Krishna delta and Nagarjunasagar. Admitting that there were problems in allocation of water to the project in the Krishna-Tungabhadra basin he said the two river systems were over-exploited and over-depended. All projects for diversion of Godavari waters to the Krishna basin would be taken up on a war- footing and would be completed in three-four years time. Diversion of Godavari waters would also help give additional water to Mahabubnagar and Nalgonda districts, he said. Page 1 © 2014 Factiva, Inc. All rights reserved. Mr. Rajasekhara Reddy stated that the first phase of Handri-Neeva would involve eight lifts with an estimated cost of Rs. -
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Tuberculosis
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Tuberculosis Chemical Activity Count (+)-3-HYDROXY-9-METHOXYPTEROCARPAN 1 (+)-8HYDROXYCALAMENENE 1 (+)-ALLOMATRINE 1 (+)-ALPHA-VINIFERIN 3 (+)-AROMOLINE 1 (+)-CASSYTHICINE 1 (+)-CATECHIN 10 (+)-CATECHIN-7-O-GALLATE 1 (+)-CATECHOL 1 (+)-CEPHARANTHINE 1 (+)-CYANIDANOL-3 1 (+)-EPIPINORESINOL 1 (+)-EUDESMA-4(14),7(11)-DIENE-3-ONE 1 (+)-GALBACIN 2 (+)-GALLOCATECHIN 3 (+)-HERNANDEZINE 1 (+)-ISOCORYDINE 2 (+)-PSEUDOEPHEDRINE 1 (+)-SYRINGARESINOL 1 (+)-SYRINGARESINOL-DI-O-BETA-D-GLUCOSIDE 2 (+)-T-CADINOL 1 (+)-VESTITONE 1 (-)-16,17-DIHYDROXY-16BETA-KAURAN-19-OIC 1 (-)-3-HYDROXY-9-METHOXYPTEROCARPAN 1 (-)-ACANTHOCARPAN 1 (-)-ALPHA-BISABOLOL 2 (-)-ALPHA-HYDRASTINE 1 Chemical Activity Count (-)-APIOCARPIN 1 (-)-ARGEMONINE 1 (-)-BETONICINE 1 (-)-BISPARTHENOLIDINE 1 (-)-BORNYL-CAFFEATE 2 (-)-BORNYL-FERULATE 2 (-)-BORNYL-P-COUMARATE 2 (-)-CANESCACARPIN 1 (-)-CENTROLOBINE 1 (-)-CLANDESTACARPIN 1 (-)-CRISTACARPIN 1 (-)-DEMETHYLMEDICARPIN 1 (-)-DICENTRINE 1 (-)-DOLICHIN-A 1 (-)-DOLICHIN-B 1 (-)-EPIAFZELECHIN 2 (-)-EPICATECHIN 6 (-)-EPICATECHIN-3-O-GALLATE 2 (-)-EPICATECHIN-GALLATE 1 (-)-EPIGALLOCATECHIN 4 (-)-EPIGALLOCATECHIN-3-O-GALLATE 1 (-)-EPIGALLOCATECHIN-GALLATE 9 (-)-EUDESMIN 1 (-)-GLYCEOCARPIN 1 (-)-GLYCEOFURAN 1 (-)-GLYCEOLLIN-I 1 (-)-GLYCEOLLIN-II 1 2 Chemical Activity Count (-)-GLYCEOLLIN-III 1 (-)-GLYCEOLLIN-IV 1 (-)-GLYCINOL 1 (-)-HYDROXYJASMONIC-ACID 1 (-)-ISOSATIVAN 1 (-)-JASMONIC-ACID 1 (-)-KAUR-16-EN-19-OIC-ACID 1 (-)-MEDICARPIN 1 (-)-VESTITOL 1 (-)-VESTITONE 1 -
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International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 8, Issue 3, 2016 Review Article THE HEALTH BENEFITS OF NATURAL SKIN UVA PHOTOPROTECTIVE COMPOUNDS FOUND IN BOTANICAL SOURCES JOHN ROJAS*, CESAR LONDOÑO, YHORS CIRO Department of Pharmacy, College of Pharmaceutical and Food Sciences, University of Antioquia, Medellin, Colombia Email: [email protected] Received: 24 Nov 2015 Revised and Accepted: 25 Jan 2016 ABSTRACT In recent years, botanicals have gained importance due to their dermal photoprotective effect against the harmful UV radiation. This radiation generates reactive oxygen species which attack proteins, lipids, and nucleic acids among others. This leads to the cellular oxidation, which is reflected as tanning, skin inflammation, erythema, immunosuppression, photoaging and skin cancer. The photoprotective activity of synthetic sunscreens is unsatisfactory due the proved incomplete spectral protection, toxicity, and allergenicity. The phytotherapy treatment with antioxidant compounds with potential UV absorbing capacity could offer a more effective photoprotection since they may impede, reverse or delay the process of formation of DNA adducts. The wide diversity of botanicals with photoprotective activity is attributed to several types of substances with phenolic chromophores. These compounds can be classified as flavonoids, phytoestrogens, carotenoids, xhantophylls, coumarins, proanthocyanidins, anthocyanins, catechins, phenolic acids, triterpenes, alkaloids, etc. The bioactivity of these compounds is not limited to the photoprotective action, but antioxidant, anti-inflammatory, antimutagenic and immunomodulatory properties. The regular intake of these botanicals not only prevents but also delays the deleterious effects of sun radiation onto the skin. Therefore, these botanicals have gained considerable attention and are now included in most vitamin and cosmetic products. -