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Shaping the Market: Gavi's Model for Bringing the Power of Vaccines To #GaviSeth Shaping the market: Gavi’s model for bringing the power of vaccines to the world’s poorest children Seth Berkley MD National Vaccine Advisory Committee 2 February 2015, Washington DC www.gavi.org The challenge: Reducing delays in launching new vaccines in poor countries 2 #vaccineswork Gavi: an innovative public-private partnership Building on the comparative advantages of both public and private partners 3 #vaccineswork Gavi-supported vaccination programmes: an overview Refers to the first Gavi-supported introduction of each vaccine. Vaccine Investment Strategy: Gavi’s approach to prioritsing new vaccines Category VIS Criteria • Cholera Impact on child mortality Health Impact on overall mortality • Dengue impact • Hepatitis A Impact on overall morbidity • Hepatitis B (birth dose) Epidemic potential Global or regional public health priority • Hepatitis E Herd immunity Additional • Influenza* impact Availability of alternative interventions considerations • Meningococcal CYW Socio-economic inequity • Malaria Gender inequity • Rabies Disease of regional importance • Yellow Fever** Capacity and supplier base • DTP booster GAVI market shaping potential Implementation Ease of supply chain integration • Enterovirus 71 feasibility • Mumps Ease of programmatic integration Vaccine efficacy and safety * Maternal vaccination Vaccine procurement cost Cost and value ** Additional mass campaigns In-country operational cost for money Procurement cost per event averted Gavi’s unusual development model Co-financing Market- shaping Donor base HOW THE CO-FINANCING POLICY WORKS Co-financing level (per dose) Source: Gavi 2015. 7 #vaccineswork Changing mindsets In the vaccine manufacturing industry CDC/ Judy Schmidt, CDC/ Amanda Mills Amanda CDC/ Schmidt,Judy CDC/ 8 #vaccineswork Changing mindsets In the vaccine manufacturing industry /2013/Adrian /2013/Adrian Brooks Gavi 9 #vaccineswork Evolution of pentavalent vaccine market Increasing volumes, growing number of suppliers, reducing prices Sources: UNICEF Supply Division 2015; country annual progress reports (requested doses). 10 #vaccineswork More secure vaccine supply 2001: 5 suppliers from 5 countries of production Belgium 1 France 1 Switzerland 1 Republic of Korea 1 Senegal 1 2001 Source: UNICEF Supply Division More secure vaccine supply 2001:2014: 516 suppliers manufacturers* from 5 countriesfrom 11 countries of production of production United Kingdom Netherlands 1 Russian Belgium 1 Federation 1 France 1 Bulgaria Germany Republic United States 2** Italy of Korea 12 China 1 Senegal 1 India 4 Singapore * Includes 14 Gavi suppliers and 2 manufacturers of Brazil 1 prequalified Gavi vaccines. Indonesia 1 ** One US manufacturer also produces in the Netherlands. Note: Country of production represents country of national regulatory agency responsible for vaccine lot release. 2014 Source: UNICEF Supply Division and WHO list of pre-qualified vaccines, 2014 China: from implementing country to Gavi donor 2002 2003 2004 Catalytic 2005 Gavi support 2006 2007 2008 2009 2010 Self-financing 2011 vaccines 2012 2013 2014 Supplier of Gavi- 2015 funded vaccines Gavi donor Advance market commitment (AMC) Accelerating the manufacture and delivery of vaccines Lewis Sala /2012/ Gavi , Loke Atul /2007/ Gavi Donors commit funds Manufacturers get Developing countries , for new vaccines that incentive to invest in R&D and Gavi pay long-term, meet stringent criteria – legally committing to lower price for the D.Rowe and are requested by supply vaccines at lower vaccines /2014/ developing countries, at prices in the long term Gavi pre-agreed price left to left right): from ( 14 #vaccineswork IFFIm frontloading Long-term donor pledges are converted into immediately available funding for immunisation Source: World Bank, 2015 15 #vaccineswork Advanced purchase commitment for Ebola • Gavi commits towards future procurement with prepayment • Merck commits to: • EUAL dossier acceptance by December 31 2015 • Make available 300,000 investigational doses by May 2016 • Submit for licensure by December 2017 16 #vaccineswork After years of progress, measles control efforts stagnating and elimination off-track MCV1 coverage stagnant for …and measles outbreaks resurgent in both past 5 years… developed and developing world Coverage with first dose of measles vaccine, % Reported measles cases July-November 2015 US: big outbreak - China: ~ first measles death 40,000 cases in 12 years, July ‘15 Jan-Sept ‘15 Launch of Global Vaccine Action Plan 90 85 80 75 DR Congo: ~ 70 20,000 cases 65 Jan-Sept ‘15 60 55 Australia: 50 Number of cases outbreak Aug-Sept ‘15 1999 2004 2009 2014 (51 countries or 26%) 0 (39 countries or 20%) 1 - 9 Global Gavi 73 (42 countries or 22%) 10 - 99 (20 countries or 10%) 100 - 999 (9 countries or 5%) ≥1000 (33 countries or 17%) No data reported to WHO HQ Not applicable Source: WHO/UNICEF Estimates of National Immunization Coverage 2014 revision, July 2015; WHO measles surveillance data as of 13 January 2016 17 #vaccineswork Gavi supporing the countries most at risk from infectious diseases Gavi supports the poorest countries, >300 infectious home to 60% of the world’s children diseases exist… …<30 currently vaccine preventable 18 #vaccineswork Powerful impact: meningitis A vaccine 450 million PEOPLE THREATENED MORE THAN 215 million PEOPLE VACCINATED SINCE 2010 IMPACT: Number450 millionof meningitis Apeople cases: live in Africa’sin “meningitis2008 in 2014 belt” across 26 countries Niger 842 0 Burkina Faso 156 0 Mali 16 0 Global health security: Gavi’s growing role in outbreak preparedness and response Yellow fever Measles outbreak Meningitis vaccine vaccine stockpile response stockpiles Oral cholera Ebola vaccine vaccine stockpile stockpile Four key enablers of vaccine development ENABLING VACCINE DEVELOPMENT Recognise the lack of market potential Build laboratory & outbreak investigation capabilities in countries Create repositories of potential agents & better catalogue their immunologic properties Develop vaccine vector platforms 21 #vaccineswork Vaccines reduce antibiotic resistance Incidence of antibiotic-resistant invasive pneumococcal disease in children < 2 years, South Africa (cases per 100,000 person-years) Source: A von Gottberg et al, for GERMS-SA. Publication submitted April 2014. Accelerating impact 2016–2020 Sources: Gavi strategic demand forecasts 9 and 10, Investing together for a healthy future: the 2016–2020 investment opportunity. THANK YOU www.gavi.org .
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