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Enthusing Children About Chemistry Climate Change and Biogenic Emissions Predicting Properties Using Informatics the Oil Industr
Summer 2008 Enthusing children about chemistry Predicting properties using informatics Climate change and biogenic emissions The oil industry’s chemical challenges As I see it... So are you finding it increasingly diffi - Oil exploration doesn’t just offer a career for engineers – cult to attract good chemists? chemists are vital, too. Sarah Houlton spoke to Schlumberger’s It can be a challenge, yes. Many of the com - pany’s chemists are recruited here, and they Tim Jones about the crucial role of chemistry in the industry often move on to other sites such as Houston or Paris, but finding them in the first place can be a challenge. Maybe one reason is that the oil People don’t think of Schlumberger as We can’t rely on being able to find suitable industry doesn’t have the greatest profile in a chemistry-using company, but an chemistries in other industries, either, mainly chemistry, and people think it employs engi - engineering one. How important is because of the high temperatures and pressures neers, not chemists. But it’s something the chemistry in oil exploration? that we have to be able to work at. Typically, the upstream oil industry cannot manage without, It’s essential! There are many challenges for upper temperature norm is now 175°C, but even if they don’t realise it! For me, maintaining chemistry in helping to maintain or increase oil we’re increasingly looking to go over 200°C. – if not enhancing – our recruitment is perhaps production. It’s going to become increasingly For heavy oil, where we heat the oil up with one of the biggest issues we face. -
Oral History of Hermann Hauser; 2014-06-20
Oral History of Hermann Hauser Interviewed by: Gardner Hendrie Recorded: June 20, 2014 Cambridge, United Kingdom CHM Reference number: X7214.2014 © 2014 Computer History Museum Oral History of Hermann Hauser Gardner Hendrie: Today we have with us Hermann Hauser, who has very graciously agreed to do an oral history for the Computer History Museum. Thank you very much, Hermann. I think I'd like to start with a little bit of your early family background, sort of have an understanding of where you came from, and it might give us some insight as to how you ended doing what you did. Hermann Hauser: OK sure. Well I was born in Vienna. My mother is Viennese, but my father is Tyrolean, so I actually grew up in the Tirol, although my father sent my mother back to Vienna to have me in the Rudolfinerhaus hospital in Vienna, but I grew up in the Tirol, which is the mountainous part of Austria where the skiing is, and we had a ski lift behind our house. I went to school in the local village. It was a tiny village that I grew up in with about 200 people or so. And with a very small local school, primary school. And then I went to Kufstein, which is about 15 kilometers from where I lived which actually was a very small part of Wörgl was called Bruckhäusl, which really was a little village that got attached to Wörgl. Hendrie: Excuse me, now did you have any brothers or sisters? Hauser: Yes. I have one brother who is five years younger than me. -
Spotlight on 2014 2 Spotlight on 2014
spotlight on 2014 2 Spotlight on 2014 table of contents introduction 3 impact in 2014 36 harnessing the power of ICT 4 events in 2014 38 safeguarding society 12 council of advisors 40 building healthier our staff 42 communities 20 clients and collaborators 44 innovating for efficiency 28 references 46 3 introduction Today’s policy world is a complex smarter across more applications, and interconnected place. Changes to build public trust in security unfolding in one area can impact while safeguarding society’s on another. For example, increasing freedoms, to improve health and the convenience of internet- mental well-being for individuals connected devices can pose and communities, and to find greater risks to our privacy and innovative and efficient spending security. solutions while not diminishing outcomes for people. While policymaking can transform the lives and environments of The interconnectedness of individuals, communities and our world will intensify, so that societies for good or ill, it is transformation, as a theme in an important but challenging policymaking, will become more business. Policy consequences important. For RAND Europe’s part, can take unexpected turns. we are proud of our achievements in 2014 but are not complacent. This is where RAND Europe aims to We look forward to new policy support policymaking. We provide transformations brought about the evidence, expertise and robust by revealing new knowledge, analysis to help inform policies to reducing the uncertainty of our change people’s lives for the better. complex world, challenging In this year’s Spotlight we highlight conventional wisdom and making our contributions to achieve this sense out of the big picture of goal. -
ISSUE 20 EASTER TERM 2014 Hughes
THE MAGAZINE OF HUGHES HALL, CAMBRIDGE ISSUE 20 EASTER TERM 2014 Hughes AFRICA PROGRAMME HONG KONG ENTREPRENEURSHIP SIR ANDREW MOTION Culture, Public Health, Loyal friends and families: Small beginnings and big War, Peace and Poetry: Research, Training: Hughes the relationships between successes: the innovators remembering the Great War engages with Africa. Hughes and Hong Kong. from Hughes Hall. at Hughes PAGE 4 PAGE 12 PAGE 14 PAGE 18 RISING HIGH – OUR SPECIAL PARTNERSHIPS IN HONG KONG DR EDWIN LEONG’S MAJOR GIFT TO HUGHES 1 IN THIS ISSUE From The President 3 Student News 20 Hughes Hall in Africa 4 The Honor Chapman Lecture 22 College and Staff News 9 PGCE – Then and Now 23 Fragrant Harbour: Hughes Hall and Hong Kong 12 Alumni News 24 Entrepreneurs 14 Overseas Trips 25 Sport 16 Hughes Hall and the Great War 26 Events 18 The first game of the season at Fenner’s 2 WELCOME From The President Dear Alumni and Friends of Hughes Hall This will reach most readers shortly before I move on from Hughes Hall at the end of August, after eight years as President. So I take this opportunity to say a warm ‘thank you’ to all those who have given such friendly support over this time, to me and to the College – and not least to the many who have responded with such wonderful generosity to the ‘leaving fund’ which goes to swell our scholarships endowment. It has been an extraordinary experience. Perhaps more than any other college, Hughes is in a state of evolution. We seek to keep the best of the past – our sense of a proud history, our friendliness and informality – and harness that to new ambitions as we grow and build our academic reputation and as we assert ourselves on the Cambridge scene. -
Alessio Ciulli
2015 Rising Stars Alessio Ciulli Alessio graduated in Chemistry (2002) from his hometown Florence under the late Ivano Bertini and obtained his PhD from the University of Cambridge (Chemistry, 2006), studying as a Gates Cambridge Scholar under the supervision of Chris Abell and in collaboration with Astex Pharmaceuticals. Following post-doctoral research on fragment-based drug design with Chris Abell and Tom Blundell, and an HFSP visiting Fellowship at Yale University to begin collaboration with Craig Crews (2009), he was awarded a BBSRC David Phillips Fellowship and returned to Cambridge to start his independent career in 2010. In 2013 Alessio was awarded an ERC Starting Grant and moved his laboratory to the School of Life Sciences at Dundee where he is currently an Associate Professor in Chemical & Structural Biology and Principal Investigator within the Division of Biological Chemistry and Drug Discovery. Alessio is the recipient of the 2014 Talented Young Italian award, the 2015 EFMC Prize for Young Medicinal Chemist in Academia, the 2015 ICBS Young Chemical Biologist Award, the 2016 RSC Capps Green Zomaya Award in medicinal computational chemistry, and the 2016 MedChemComm Emerging Investigator Lectureship. Current Research Research in the Ciulli Lab is concerned with understanding molecular recognition of protein-protein interactions (PPIs) within the ubiquitin/proteasome and the chromatin/nucleosomes systems, and exploiting druggability to small molecule modulators for chemical biology and drug discovery. We employ a question-driven, multi-disciplinary approach that combines chemical, biochemical, biophysical and structural techniques with the concepts of fragment-based and structure-based drug design. Current research efforts are directed towards interrogating PPIs and protein recognition within protein families of biological and medical relevance including 1. -
CICR Newsletter Template
1. From the Editors From the Editors, with Dr Iain D.G. Watson, Editorial Board Member Each quarter, the editorial board selects an area to highlight from the broad range of topics that fall under the umbrella of chemistry in cancer research. Our topic this quarter is the ubiquitin proteasome system. CICR editorial board member Iain Watson has taken the lead in assembling an overview of the topic. The ubiquitin proteasome system (UPS) In 2004 the Nobel Prize in Chemistry was awarded to Aaron Ciechanover, Avram Hershko and Irwin Rose for the discovery of ubiquitin-mediated proteolysis. These are the cellular processes by which proteins are identified for breakdown and elimination. Central to this system is the post-translational tagging of proteins with ubiquitin, a 76 amino-acid protein. Ubiquitin is activated, conjugated and ligated onto target proteins, most commonly between a lysine on the target protein and the C-terminal glycine of ubiquitin. This collaborative cascade is catalyzed by enzymes known as E1, E2 and E3 ligases, where an E1 enzyme may bind many E2s, which bind many E3s hierarchically, allowing regulation of the cellular machinery. Ubiquitination is reversible which is catalyzed by families of deubiquitinase enzymes (DUBs). Tagged proteins are transported to a large cylindrical multisubunit protease complex called the proteasome to be degraded. The common 26S proteasome is comprised of one 20S core particle and two regulatory 19S particles which recognize the ubiquitinated proteins, unfold them and feed them into the catalytic core. Numerous cellular processes are regulated by ubiquitin-mediated proteolysis including the cell cycle, DNA repair, transcription, protein quality control and the immune response. -
978-3-642-33899-1 15 Chapter.P
Computing for the Masses? Constructing a British Culture of Computing in the Home Tilly Blyth To cite this version: Tilly Blyth. Computing for the Masses? Constructing a British Culture of Computing in the Home. Arthur Tatnall. Reflections on the History of Computing : Preserving Memories and Sharing Stories, AICT-387, Springer, pp.231-242, 2012, IFIP Advances in Information and Communication Technology (SURVEY), 10.1007/978-3-642-33899-1_15. hal-01526798 HAL Id: hal-01526798 https://hal.inria.fr/hal-01526798 Submitted on 23 May 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution| 4.0 International License Computing for the Masses? Constructing a British Culture of Computing in the Home Tilly Blyth Keeper of Technology and Engineering, Science Museum, London [email protected] Abstract: The creation of the personal computer during the late 1970s and early 1980s is heralded as a time that people were liberated by computers as tools for everyone. The proliferation of affordable and relatively powerful computers changed the landscape of computing across the globe. This chapter looks at the introduction of one machine, the BBC Microcomputer, and its influence on the culture of computing in Britain. -
Adrian Oldknow [email protected] 6Th Feb 2018 Good
Inspirational Technology for kids (of all ages) Adrian Oldknow [email protected] 6th Feb 2018 Good evening. I am very grateful to the IET and IMechE for inviting me along this evening. It’s just a year since I met Hamish McNaughton, David James and John Halliday in our local Wilke’s Head pub to plan tonight’s talk. Of course much has changed in that time, so maybe a better title now would be `Confessions of a Volunteer Ambassador’. I just wonder if any of you are old enough to remember James Burke and his Connections programmes from 1978? That’s really what my life has been all about: Only Connect! I’ve brought along a few of my diaries to help steer my path through this talk. Going back to Saturday 3rd December 2016 I find that is when my great friend Phil Moffitt, IET Schools Liaison Officer for Medway and Kent, took me along as his partner to the SE IMechE Christmas lunch in Tunbridge Wells! Phil gave a presentation on the iSTEM+ approach, of which more later, and we ran a hands-on workshop using a variety of kit with the BBC micro:bit. Another of the guests at the meeting was last year’s IET President, Prof Jeremy Watson, who lives in Worthing. On Tuesday 13th December I was the warm act before Christmas lunch with our local retirees’ `Beta Plus Computer Club’ where I talked introduced some of the current commercial robotic toys: Edison, Sphero & Ollie, OhBot and Meccanoid. I also went on to talk a bit about the sorts of technology such as Raspberry Pi, Crumble and BBC micro:bit which are being used in the Primary and Secondary schools I am working in. -
Lessons from Discarded Computer Architectures Andrew E
Lessons from Discarded Computer Architectures Andrew E. Fluck To cite this version: Andrew E. Fluck. Lessons from Discarded Computer Architectures. IFIP WG 9.7 International Conference on History of Computing (HC) / Held as Part of World Computer Congress (WCC), Sep 2010, Brisbane, Australia. pp.198-205, 10.1007/978-3-642-15199-6_20. hal-01054654 HAL Id: hal-01054654 https://hal.inria.fr/hal-01054654 Submitted on 7 Aug 2014 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution| 4.0 International License Lessons from Discarded Computer Architectures Andrew E. Fluck University of Tasmania Locked Bag 1307, Launceston, Tasmania, 7250, AUSTRALIA [email protected] Abstract: The BBC microcomputer was one of several nationally produced which were superseded by the International Business Machines (IBM) Personal Computer (PC). This reflected the results of both an international market competition and rivalry between different US processor manufacturers. Along with the hardware, valuable software and supporting educational ideologies were discarded. As we make choices about technological innovation, to what degree are we selecting potential efficacy or responding to marketing hype? Keywords: BBC microcomputer, IBM Personal Computer, Apple II, computer hardware, operating systems 1 Introduction The BBC microcomputer was an 8-bit machine based on the Motorola 6502 processor. -
GRADUATION 2014 Presentation Speech for Dr Hermann Hauser For
GRADUATION 2014 Presentation speech for Dr Hermann Hauser for the honorary degree of Master of Arts of the University honoris causa Chancellor, When Hermann Hauser became a Fellow of the Royal Society, he was described as a Science Entrepreneur, whose ventures had been at the forefront of UK innovation. Above all he had been an inspiration for generations of entrepreneurs who had been directly involved in many companies, providing enthusiasm, mentoring and financing leading to technology based wealth creation. It sounds admirable but rather like a modernized version of the list of Ciceronian virtues carved on an 18 th century tombstone. We get a better sense of our Honorand from Micro Men, the affectionately comic drama about the British home computer boom of the early 80s in which the legendary inventor Sir Clive Sinclair battles it out with the founders of Acorn Computers – Chris Curry and Hermann Hauser. It is striking that Hauser still says that some of his best moments are when people come up to him in the street and say ‘Thanks for the BBC Micro.’ The BBC Micro, fondly known as the Beeb was indeed absolutely to educating the UK about the IT revolution. But, Chancellor, there is a great deal more to our Honorand. Under his guidance, Acorn spun out ARM, E-trade, Virata and Cambridge network. He spent some time as vice president of research at Olivetti and 1997 1 he founded Amadeus Capital Partners. I think what makes him really important is his understanding of the ways in which innovation, science clusters and venture capital should fit together. -
Open Innovationinnovation –– Turningturning Researchresearch Andand Ideasideas Intointo Businessbusiness
OpenOpen InnovationInnovation –– TurningTurning ResearchResearch andand IdeasIdeas intointo BusinessBusiness Why Creativity and Innovation – and connecting Universities to Business and the Community are keys to Economic and Social Development And Examples of Open Innovation in Practice Butterfield Enterprise Innovation Day 21st April 2010 Professor Alan Barrell – Entrepreneur in Residence – Centre for Entrepreneurial Learning Judge Business School Cambridge - Laurea University of Applied Sciences Helsinki- Visiting Professor - University of Bedfordshire Some of the “Hats I wear” (or have worn) 12 years in Industrial 5 Years in Venture Capital electronics – DOMINO plc – Cambridge Gateway Fund And ALWAYS – “in, out and around” the NHS A Preview • Some Definitions – Creativity and Innovation • Our Context – a World of Dynamic Change • Mindset – What we think determines what we are and what we do – the Entrepreneurial Mindset • Role Models and Case Histories – so “what’s NEW about Innovation”? • Converging Technologies and Open Innovation • Cultural Diversity and Innovation • Open Innovation Campuses – Real and Virtual • The Nokia, Philips and Unilever examples • Symbiosis and Innovation – Small can definitely be beautiful – and large can be flexible. • Innovation and a balanced society – Academia, Business and Policy Makers – in bed together! My Definitions •• CREATIVITYCREATIVITY –– TheThe abilityability toto developdevelop newnew ideasideas andand discoverdiscover newnew waysways ofof lookinglooking atat problemsproblems andand opportunitiesopportunities -
OF the 1980S
THAT MADE THE HOME COMPUTER REVOLUTION OF THE 1980s 23 THAT MADE THE HOME COMPUTER REVOLUTION OF THE 1980s First published in 2021 by Raspberry Pi Trading Ltd, Maurice Wilkes Building, St. John’s Innovation Park, Cowley Road, Cambridge, CB4 0DS Publishing Director Editors Russell Barnes Phil King, Simon Brew Sub Editor Design Nicola King Critical Media Illustrations CEO Sam Alder with Brian O Halloran Eben Upton ISBN 978-1-912047-90-1 The publisher, and contributors accept no responsibility in respect of any omissions or errors relating to goods, products or services referred to or advertised in this book. Except where otherwise noted, the content of this book is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0). Contents Introduction. 6 Research Machines 380Z. 8 Commodore PET 2001. 18 Apple II. 36 Sinclair ZX80 and ZX81. 46 Commodore VIC-20 . 60 IBM Personal Computer (5150). 78 BBC Micro . 90 Sinclair ZX Spectrum. 114 Dragon 32. 138 Commodore 64. 150 Acorn Electron . .166 Apple Macintosh . .176 Amstrad CPC 464. 194 Sinclair QL . .210 Atari 520ST. 222 Commodore Amiga. 234 Amstrad PCW 8256. 256 Acorn Archimedes . .268 Epilogue: Whatever happened to the British PC? . .280 Acknowledgements . 281 Further reading, further viewing, and forums. 283 Index . .286 The chapters are arranged in order of each computer’s availability in the UK, as reflected by each model’s date of review in Personal Computer World magazine. Introduction The 1980s was, categorically, the best decade ever. Not just because it gave us Duran Duran and E.T., not even because of the Sony Walkman.