Table S1. measured by using the PCR Array

Gene Product Regulation Response to BDNF Function

Adrb1 Adrenoceptor beta 1 CRE ns

Ahr Aryl hydrocarbon CRE ns

Ubiquitous enzyme found in nearly all Adenosylmethionine Amd1 CRE Increased (*) mammalian cells; may be involved with cell decarboxylase 1 growth

May act as a growth factor during central Areg Amphiregulin CRE Increased (*) nervous system development

Atf3 Activating transcription factor 3 CRE Increased (*) Expression is associated with neuronal injury

Bcl2 BCL2, regulator CRE ns

Plays a role in the development of hippocampal Bdnf Brain-derived neurotrophic factor CRE Increased (*) long term potentiation; involved in regulation of synaptic plasticity

Brca1 BRCA1, DNA repair associated CRE ns

Calb1 Calbindin 1 CaRE ns

Calb2 Calbindin 2 CaRE ns

G- coupled receptor for either calcitonin Calcrl like receptor CaRE Increased (*) -related peptide or adrenomedullin that may play a role in vascular tone

Calm1 Calmodulin 1 CaRE ns

Calr Calreticulin CaRE ns

Ccna1 Cyclin A1 CRE ns

Ccnd1 Cyclin D1 CRE ns

Cdk5 Cyclin-dependent kinase 5 CRE ns

Cyclin-dependent kinase inhibitor Cdkn2b CRE ns 2B

Chga Chromogranin A CRE ns cAMP responsive element binding Creb1 CRE ns protein 1

cAMP responsive element Interacts with CREB and appears to modulate its Crem CRE Increased (*) modulator response.

Crh Corticotropin releasing hormone CRE ns

Ctf1 Cardiotrophin 1 CRE ns

Cellular communication network Cyr61 SRE ns factor 1

Ddit3 DNA-damage inducible transcript 3 CaRE Increased (*) Plays a role in the ER stress response

This gene encodes a protein that catalyzes the dephosphorylation and inactivation of MAP Dusp1 Dual specificity phosphatase 1 CRE Increased (*) kinase, and may be involved in insulin mediated signalling

Activates transcription of the LH receptor gene; Egr1 Early growth response 1 CRE and SRE Increased (**) may be involved in synaptic plasticity during REM sleep

Binds DNA; may play a role in learning and long Egr2 Early growth response 2 CRE and SRE Increased (**) term potentiation

Eno2 Enolase 2 CRE ns

Fos proto-oncogene, AP-1 An immediate early gene encoding a nuclear Fos CRE and SRE Increased (**) transcription factor subunit protein involved in signal transduction

Gcg Glucagon CRE ns

GTP binding protein overexpressed GTPase associated to neurons apoptosis and Gem CRE Increased (*) in skeletal muscle morphology regulation

Gastric inhibitory polypeptide Gipr CRE ns receptor

Hk2 Hexokinase 2 CRE ns

Heat shock protein family A Hspa4 SRE ns member 4

Il6 Interleukin 6 CRE ns

Inhba Inhibin subunit beta A CRE ns JunB proto-oncogene, AP-1 Transcription factor; involved in transcriptional Junb SRE Increased (**) transcription factor subunit regulation

JunD proto-oncogene, AP-1 Jund CRE ns transcription factor subunit Potassium voltage-gated channel, Kcna5 shaker-related subfamily, member CRE ns 5

Ldha Lactate dehydrogenase A CRE ns

Avian musculoaponeurotic Maf CRE ns fibrosarcoma oncogene homolog Macrophage migration inhibitory Mif factor (glycosylation-inhibiting CRE ns factor)

Ncam1 Neural cell adhesion molecule 1 CaRE ns

GTPase-activating protein that negatively Nf1 Neurofibromin 1 CRE Increased (*) regulates RAS/MAPK pathway. Linked to Neurofibromatosis type 1

Nos2 Nitric oxide synthase 2, inducible CRE ns

Npy Y CaRE ns

Nuclear receptor subfamily 4, Nr4a2 CRE and SRE ns group A, member 2

Phosphoenolpyruvate Pck2 CRE ns carboxykinase 2 (mitochondrial)

Processivity factor for DNA polymerase δ. It acts as a scaffold to recruit involved in DNA Pcna Proliferating cell nuclear antigen CRE Increased (*) replication, DNA repair and chromatin remodeling

Penk Preproenkephalin CRE ns

Per1 Period circadian clock 1 CRE ns

Plat Plasminogen activator, tissue CaRE ns

Pln Phospholamban CRE ns

Phorbol-12-myristate-13-acetate- Pmaip1 CRE ns induced protein 1

POU domain, class 1, transcription Pou1f1 CRE ns factor 1

Protein phosphatase 1, regulatory Ppp1r15a CRE ns subunit 15A Protein phosphatase 2 (formerly Ppp2ca 2A), catalytic subunit, alpha CRE ns isoform Protein kinase, cAMP dependent Prkar1a CRE ns regulatory, type I, alpha

Prostaglandin-endoperoxide Ptgs2 CRE ns synthase 2

Rb1 RB transcriptional corepressor 1 CRE ns

May function in stimulation of Ca2+-dependent S100 calcium binding protein A6 S100a6 CRE Decreased (***) insulin release, stimulation of prolactin secretion, (calcyclin) and exocytosis

Involved in the packaging or sorting of peptide Scg2 Secretogranin II CRE and SRE Increased (**) hormones and for secretion. Cleaved to secretoneurin.

Serum/glucocorticoid regulated Sgk1 CRE ns kinase 1

Solute carrier family 18 (vesicular Slc18a1 CRE ns monoamine), member 1

Superoxide dismutase 2, Sod2 CRE ns mitochondrial

Srf Serum response factor SRE ns

Sst CRE ns

Sstr2 2 CRE ns

When phosphorylated, it translocate to the Signal transducer and activator of Stat3 CRE Increased (*) nucleus to activate transcription. Plays a roles in transcription 3 cell growth and apoptosis.

G-protein coupled receptor for . Associated to nitric oxide formation, expresed by Tacr1 1 CRE Decreased (**) cholinergic and nitrergic neurons as well as on smooth muscle cells

Tgfb3 Transforming growth factor, beta 3 CRE ns

Th hydroxylase CRE ns

Thbs1 Thrombospondin 1 SRE ns

Tnf Tumor necrosis factor CRE ns

Vcl Vinculin SRE ns

Vip Vasoactive intestinal polypeptide CRE ns

Level of significance: ns = non significant * = p < 0.01 ** = p < 0.001 *** = p < 0.0001