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Outbreak of Datura Ingestion at a Juvenile Correctional Facility

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Outbreak of Datura Ingestion at a Juvenile Correctional Facility Peer Reviewed Title: Outbreak of Datura Ingestion at a Juvenile Correctional Facility Journal Issue: Western Journal of Emergency Medicine, 2(3) Author: Wenker, Keri MD, Division of Emergency Medicine, University of California Irvine Medical Center Suchard, Jeffrey MD, Division of Emergency Medicine, University of California Irvine Medical Center Publication Date: 2001 Publication Info: Western Journal of Emergency Medicine, Department of Emergency Medicine (UCI), UC Irvine Permalink: http://escholarship.org/uc/item/67h1j7c3 Keywords: Datura License Statement: This is an Open Access article distributed under the terms of the Creative Commons Non- Commercial Attribution License, which permits its use in any digital medium, provided the original work is properly cited and not altered. For details, please refer to http://creativecommons.org/ licenses/by-nc/3.0/. Authors grant Western Journal of Emergency Medicine as well as the National Library of Medicine a nonexclusive license to publish the manuscript. Western Journal of Emergency Medicine is produced by the eScholarship Repository and bepress. eScholarship provides open access, scholarly publishing services to the University of California and delivers a dynamic research platform to scholars worldwide. The California Journal of Emergency Medicine II:3, July 2001 page 37 Original Corztributiorz: Case Series Outbreak of Datura Ingestion at a 3ilaterally and dry oral mucous membranes, but was otherwise unremarkable. The patient was alert and fully oriented and Juvenile Correctional Facility willingly offered to have blood or urine samples sent for drug testing, as he denied abusing any drugs. A rapid urine drugs-of- Keri Wenker MD" lbuse screen was negative, and the patient was discharged back to Jeffrey Suchard MD* the correctional facility. *Division of Emergency Medicine University of California Irvine Medical Center Later that same day, the mental status of the first Orange, California patient cleared, and he admitted to ingesting Jimsonweed on two occasions within the prior two days. Introduction: Datlira strainoni~cnt,or Jimsonweed, may be abused for Two days later, two other adolescent male residents of its reputed hallucinogenic and euphoric effects. We report an the same facility were sent to the ED for evaluation of dilated outbreak of Jimsonweed ingestion at a juvenile correctional pupils. These patients were also asymptomatic, and their vital facility where the staff presumed their residents had no access to signs and physical examinations were normal, except for psychoactive substances. mydriasis. The guards accompanying one of these patients also brought a sample of the plant that the boys were believed to have Case Series: ingested; a Medical Toxicologist identified the plant as Datura A juvenile correctional facility sent a 16-year-old male ~tramonium.Both of these patients were discharged without resident to the Emergency Department (ED) for medical additional testing. One of the treating physicians then called the evaluation. The patient had been confused and had dilated pupils medical unit at the correctional facility to recommend that for approximately 8 hours prior to presentation, but the patient asymptomatic patients with suspected Jimsonweed ingestions and his accompanying guards were unable to provide any should simply be observed, and the local Poison Control Center additional helpful history. Vital signs were: temperature 37.2OC should be contacted, since no testing or treatment would be (oral), pulse 125/min, respirations i 8/min, and blood pressure indicated. No further patients were referred to the ED. 146188 mMg. Physical examination revealed an awake, agitated adolescent, with a mumbling. tangential and pressured speech An interview with the correctional facility's administra- pattern, apparently responding to auditory and visual hallucina- tors revealed more details about the outbreak of Datura ingestion. tions and occasionally picking at himself. Pupils were 8 mm This particular facility predominantly housed adolescents bilaterally and sluggishly reactive to light. The oral mucous detained for drug-related charges, and therefore routinely acted to membranes and skin were dry. Cardiovascular exam revealed a prevent their residents from gaining access to psychoactive drugs, regular tachycardia, while the lung and abdominal exams were including searches and limited use of psychoactive pharmaceuti- unremarkable. The patient was able to ambulate, move all four cals. The recreational grounds were separated from an elevated extremities, and follow simple commands, but appeared jittery freeway off-ramp by a small sloping strip of land with and was unable to sit still. groundcover to prevent erosion. Many weeds were growing in this groundcover, including some Datura stramo?zium plants The patient's complete blood count and basic metabolic abutting the chain-link fence on the facility's perimeter. In pane1 were within normal limits. Urinalysis and rapid urine addition to the four patients evaluated in the ED, one other male drugs-of-abuse screen by enzyme-multiplied immunoassay youth was involved in a conspiracy to obtain Jimsonweed seeds technique were negative. An electrocardiogram demonstrated a for ingestion. These youths would play softball and intentionally sinus rhythm at 113 beats/min with QRS duration 76 msec and overthrow the ball towards right field, so that it would come to QTc interval 437 msec; this tachycardia persisted despite rest against the chain-link fence. When retrieving the ball, they administration of intravenous (IV) fluids. Sedation totaling 2 mg would stoop down and also gather up Jimsonweed seeds. The midazolam IV and 10 mg haloperidol IV was given to facilitate administrators printed and distributed warning posters that examination, including a non-contrast head CT scan that was included a picture of Jimsonweed throughout their facility, and normal. The patient was then admitted to the pediatric ward had a work detail remove the Jimsonweed plants. However, more service for further observation of presumed anticholinergic Jimsonweed plants were noted to have had sprouted up when the toxicity. authors toured the facility a few months later. Just after the first patient was transported to the Discussion: pediatric floor, a second patient from the same correctional Datura stramoiziunz is a ubiquitous plant in the United facility arrived in the ED for evaluation of dilated pupils and States, also sometimes referred to as Jimsonweed, thornapple, suspected drug ingestion. This patient had a borderline tachycar- locoweed, devil's weed. devil's apple. green dragon, and stink- dia with a pulse rate of 95/min, but he had otherwise normal vital weed. Like other members of the Solanaceae plant family, D. signs and was without any physical complaints. Physical stramoniurn contains tropane alkaloids, particularly hyos- examination revealed mydriasis with pupils measuring 8 mm cyamine, hyoscine, and their respective racemates, atropine and scopolamine.' These alkaloids are competitive inhibitors of acetylcholine at muscarinic receptors within the central and The California Journal of Emergency Medicine II:3, July 2001 page 38 peripheral nervous systems. Datum toxicity, therefore, produces References an anticholinergic toxidrome, which may include hyperpyrexia, anhydrosis. tachycardia, mydriasis and cycloplegia, decreased 1. Evans WC led.]. Alkalojds. Trease and Evans' peristalsis, urinary retention, altered mental status, agitation, and Pharmacognos~~.WB Saunders Company Ltd, hallucinations. Seizures and death may occur in the most Philadelphia PA. 14thEd, 1996, pp 346-35 1. seriously poisoned patients. All portions of the plant are toxic, although the highest concentrations of alkaloids are found in the 2. CDC. Jimson Weed Poisoning -Texas, New York. seeds and seed pods.? and California, 1994. Morbid Mortal Wkly Rep 1995;44:41-44. Treatment of Datura intoxication includes standard resuscitation and supportive measures. and observation. 3. Litzinger WJ. Ceramic Evidence for Prehistoric Activated charcoal andlor gastric lavage may be considered, Datum Use in North America. J Ethnopharmacol although they are probably of more benefit to patients ingesting 1981:4:57-74. plant parts rather than those consuming a "tea" made from the plant. Agitation may be treated with benzodiazepines. a quiet 4. Klein-Schw~zW* Oderda GM. Jimsonweed environment, and restraints when necessary. With seizures, Intoxication in Adolescents and Young Adults. Am 9 uncontrollable agitation, or other life-threatening complications of Dis Child 1984;138:737-739. anticholinergic toxicity, physostigmine may have a beneficial antidotal effect. Physostigmine is typically given by slow IV 5. Tiongson 9, Salen Fs. Mass Ingestion of Jimson 'Weed push in 0.5 mg increments, up to 2.0 mg. [More details regarding by Eleven Teenagers. DeI Med 4 1998;70:471-476. the judicious use of physostigmine for anticholinergic toxicity will be given in an upcoming article in this series.] Many patients 6. Shervette RE, Schydlower M, Lampe M, Fearnow recover well with minimal interventions. RG. Jimson "Loco" Weed Abuse in Adolescents. Pediatrics 1979;63:520-523. The pharmacologic effects of Daturu species have been intentionally exploited for centuries. Evidence of religious or 7. O'Grady TC, Brown J, Jacamo 3. Outbreak of ritualistic use by Native Americans dates back to 700 AD.3 A Jimson Weed Abuse Among Marine Corps Personnel mass ingestion of D. strumonium by British soldiers in at Camp Pendleton.
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